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<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSC8</accession>
    <name>R4VSC8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00825"/>
    <dbReference type="EnsemblBacteria" id="AGN00120">
        <property type="protein sequence ID" value="AGN00120"/>
        <property type="gene ID" value="L593_00825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181447"/>
    <dbReference type="KEGG" id="sali:L593_00825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.169"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_489691_0_0_2"/>
    <dbReference type="OrthoDB" id="81123at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
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            <begin position="377"/>
            <end position="410"/>
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        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="547" mass="57378" checksum="8F6AE4E267D39DDB" modified="2013-07-24" version="1">MSSAGPGRREVAHRLFAAEYDDATLEYAESDEERAPNYVVLPSGARVNRLFVVGVLTAVEQVNDDTVRARIADPTGAFVVYAGQYQPDELAAFQSLEAPAFVAVTGKANTFSPEGSDRVLTSVRPESVTEVDAETRDRWVVATAEHTLARVQTAAEALGMDERGEGLQRALLRDGVEPGLAEGISRAIDHYDTSTDYLDALRQVATQALEVVADERSEVEALDREPAGGDGTTTASDLTSLVDEERLSVTQAAGDVDPDVLLGDEPDGEEPDGEEPEEAEETGEEEEATSGTEATDAETEPAEGGSAEPTEATEEPESSTSEPAGEQTADEDATAADTGADRDEQDSTGVAQPETGEDAPAESATEPAKAAVDESAETEETTEGEEPSESDESEADGELYEVDEAEREQIEEEYGVGFQSGTEVDPAGEAGIETDDTPPGANEGEEPAAVEASDETDGAEAESESVADDDDEDSESEDAESEDVDLEGVLLEEMSALDDGDGADREALIDAVAGTTGADADAIDDAIDDLLMSGQCYEPGDGQLKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSG9</accession>
    <name>R4VSG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01000"/>
    <dbReference type="EnsemblBacteria" id="AGN00155">
        <property type="protein sequence ID" value="AGN00155"/>
        <property type="gene ID" value="L593_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.205"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_2_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="24591" checksum="2CB964EE694B45B1" modified="2013-07-24" version="1">MTTVPDALPNWEVPGATERPYPAVAAEMQRTLADDSSGHDLAHAWRVFSLGRSIAKKEGADPHVVGLAALVHDHHRVVNGHEFVHPEATLDDVEAILTSAEVTNTATIDAVKHCVAVHDDYEYRDDPRNPETIEAEVLQDADNLDALGAVGVGRCFAFGGDRGLPLWRPDRDDPCVLGHFDEKLYKLEAECNTETARAMAADRIAFLEEFAERFRQEWRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU31</accession>
    <name>R4VU31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_03745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445594.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03745"/>
    <dbReference type="EnsemblBacteria" id="AGN00700">
        <property type="protein sequence ID" value="AGN00700"/>
        <property type="gene ID" value="L593_03745"/>
    </dbReference>
    <dbReference type="GeneID" id="16180675"/>
    <dbReference type="KEGG" id="sali:L593_03745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.760"/>
    <dbReference type="eggNOG" id="arCOG01181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_1_0_2"/>
    <dbReference type="OrthoDB" id="74143at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="94"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="34279" checksum="2BBF90D2676054E5" modified="2013-07-24" version="1">MVQNVAGIVAELEPEDVHLLSGVEHGMRFSEWVARSKLPEFSGLTPENVDYRLERCVDFELVERKTIQYEGFKLTYEGYDALALYTFAERETITGVGASLGVGKESDVYEVESYRPLALKYHREGVTNFRKVAKERDYTSDHEHVSWLYTARKAAEREYEALEALYPDVSVPRPIDQNRHAIVMEKMDGVELSRTRLEDEQVLGVLDLLLREIQTAYAEGYVHGDMSEYNVFVAEDGVTIFDWPQSIPTDHENAEEYLDRDVGNVLGYFERKYPGFVGDVSASAIADAIREDEFHGIAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUH7</accession>
    <name>R4VUH7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445759.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04580"/>
    <dbReference type="EnsemblBacteria" id="AGN00865">
        <property type="protein sequence ID" value="AGN00865"/>
        <property type="gene ID" value="L593_04580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181002"/>
    <dbReference type="KEGG" id="sali:L593_04580"/>
    <dbReference type="eggNOG" id="arCOG08932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_1_2"/>
    <dbReference type="OrthoDB" id="66429at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="35061" checksum="F0D851BDFEDC4E0C" modified="2013-07-24" version="1">MSPPAPLAGSDGDRVLVLNPAAGDGEHAATIYDLAGQYDFEIRETDSAEDVVETAADAAPDASMLAAAGGDGTLTRAVRGIDRADAFDDTTFGVVPAGTGNSFAGNLGITGLEHAFEVLTEGEIRTIDVGTIDDTPFLNSVVAGLTAESSADTASASKERWGVLAYAMTTASTAAAFDGLHLTIDPVDSDPWETEAGIVMIGNGRRFPRPGGSQAHLEDGLLDVAVVEQASTLELAGQSLRHAVSEADGVAEFRTQSVTVEIHGDRDRISVDGEIETAESFSAGVRPGVLELAVGESYDPDPDGYESDPDGDDPEPERDDPEPDGSADADSVPTGLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUQ6</accession>
    <name>R4VUQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445854.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05055"/>
    <dbReference type="EnsemblBacteria" id="AGN00960">
        <property type="protein sequence ID" value="AGN00960"/>
        <property type="gene ID" value="L593_05055"/>
    </dbReference>
    <dbReference type="GeneID" id="16181192"/>
    <dbReference type="KEGG" id="sali:L593_05055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1031"/>
    <dbReference type="eggNOG" id="arCOG00848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102053_0_0_2"/>
    <dbReference type="OrthoDB" id="98413at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="157" mass="17778" checksum="5982761410DADD8C" modified="2013-07-24" version="1">MSVTVETRSVGPGSDEYLEAAWELKERIRRSEGVLKQRRGFFADAYRRSRVHVLLADEEVVGFAAVRRDGYVLFLAIASEYRGQGFGERLIARVAEEHDSITCHARASNEGALGFYENLGFEIRRRIDNYYEDGGDAYYLKLGEDTGLTSKITDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUT1</accession>
    <name>R4VUT1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">eno</name>
        <name evidence="12" type="ORF">L593_05205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445884.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05205"/>
    <dbReference type="EnsemblBacteria" id="AGN00990">
        <property type="protein sequence ID" value="AGN00990"/>
        <property type="gene ID" value="L593_05205"/>
    </dbReference>
    <dbReference type="GeneID" id="16181273"/>
    <dbReference type="KEGG" id="sali:L593_05205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1063"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_1_2"/>
    <dbReference type="OrthoDB" id="23221at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="130"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="400" mass="42217" checksum="984960A4E34033B9" modified="2013-07-24" version="1">MVLITDVRLRRILDSRGNATVEADVLTETGGFGRAAAPSGASTGEYEAIELPAAEAIAAAREHAIPRLVGEVHVGDQRSVDRTLRAADGTDDFSEIGANSAVAISMAAAKAAADTLGAPLYQHLGGAFRGDSFPTPLGNVVGGGEHAADATHIQEFLSAPVGAPNVQEAVFANAAVHARVAELLHEDGIAAGKGDEGAWAPSIDDAEAFDLVEQAVDDVEDEVGFEIRFGLDVAGAELYEDGEYHYGEETRSTEEQIDYMVDLIEEYDLVYVEDPLDENDYEAFANLTDRVDGDRTLICGDDLFVTNVERLQTGIDTGAANSILIKPNQIGTLTDAVDAIELARENGLASVVSHRSGETEDATIAHLAVATDVPFIKTGAVGGERTAKLNELIRIDDDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUY5</accession>
    <name>R4VUY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444975.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00630"/>
    <dbReference type="EnsemblBacteria" id="AGN00081">
        <property type="protein sequence ID" value="AGN00081"/>
        <property type="gene ID" value="L593_00630"/>
    </dbReference>
    <dbReference type="GeneID" id="16181853"/>
    <dbReference type="KEGG" id="sali:L593_00630"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_2"/>
    <dbReference type="OrthoDB" id="50904at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="38617" checksum="743C9E69075757F6" modified="2013-07-24" version="1">MTYRFVGANFDQMHMNTNLDWVADHPDAEIVGVCDEDPSTSTGSLDDAVEAHDIPEDAVYEDLDRCIEETDPDVVLGCPMNSEHANFVERVAPHDVHVALEKPLADTLENADRMIDAMDETGNLFVLNWPVSWDPVKHEVRRLVQDGTLGDVVEVQYYGGNSGAPPDDSWFYDRDAGGGSMLDYLGYGATFSTWFRDGHLPESISAEEYVPEDFDVDVQSSTIARFEDGLSAFQTSWRMPTNPWEIEPQPMKGYVVVGTEGSISTVERGVEIRVQTDDEPEGYEVEPSPLPDRFRNLIYYIVNRLETGEDPEGPCDPEFCREAHRIVETAKRSAQAGERVALVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV62</accession>
    <name>R4VV62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_05880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446019.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05880"/>
    <dbReference type="EnsemblBacteria" id="AGN01125">
        <property type="protein sequence ID" value="AGN01125"/>
        <property type="gene ID" value="L593_05880"/>
    </dbReference>
    <dbReference type="GeneID" id="16181851"/>
    <dbReference type="KEGG" id="sali:L593_05880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1204"/>
    <dbReference type="eggNOG" id="arCOG02362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_2"/>
    <dbReference type="OrthoDB" id="4671at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="404"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="476"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="375"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="619"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="992" mass="105429" checksum="8FBB6DAE54BCDD54" modified="2013-07-24" version="1">MTPNISSYLVPSFIQRRYTAKFVVSILFVLVAIGIVGYVGYAQVSTIENSIEGQIGEETENNLRETSELQAGSLNEWTTRMEYQARLVGQLPDVSDGSPQNARGRLSAYASTLDGFSSIHLVHLEDQEVLTSTAGTSELDSGTSFSEIDEPWATDGLARNISGGQVWVSDGAYPSVSVPGRRVIAFAAPTQNPDRAVVLTASIDIRLEQLSREGSARTTQIVNEEGAFVLQDNASGAVHLHEEELSQVEQALADDTVAFSDHGDSLQAYAPVDGPSQATDWVAVTSVPKEEAYAVRDTVGQEVRESVGQLLLAIVAVAFLSLGIMGFILGRQTVTPLRRLQSKAQSMEEGNLDVDLETGRKDEIGQLYRAFDSMRLSLREQIQEAQSAREEAEAERERIQRINKQLEATADDYSDVMQRAAEGDLTARMATTTENEAMAAIADEYNEMLAEIEQTIEELNAFAAEVATASEQVTASSEEVRSASEQISDSVQEISAGAERQNDSLQSVNQEMSDLSTTTEEIAASSNEVADIAERTAETGKAGRDAAQAAIASMREIEDESSRAVEEINQLETEVGQIDELIERIQEISDQTNMLALNANIEASRSTSGEGDGGFGVVAQEVKELSQDAKDAAEEIEDRLESIRHQTQRSAEEVEQTSEDVDEASTQVANAVEALEEIAEYAGETNTGVQEISAATEEQAASTQEVVAMVDEAATISEETTAESESVAAAAEQQTTALTEVSNSASDLSEQAARLSEALDRFDTDAELEGAETRMLEGEQIDEESPAGGLGDEELPDGDLTEEELPEGDELDDGTPAESADDVDEDIDAFQPGVEADEFGADTAAGPEGGADEPAASPAAEPDDAEPVEPMDTDDAEGVDDAEPDADTAAEETDQTGEDVFDFGQSEGSEVVGDLDDESAGAGDDAAEAAGDVADLALTDVSGVGDAKAEALRAAGYETVADLRAASQAQLAQVEGIGDALAVEIKDDVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVD1</accession>
    <name>R4VVD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445090.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01215"/>
    <dbReference type="EnsemblBacteria" id="AGN00196">
        <property type="protein sequence ID" value="AGN00196"/>
        <property type="gene ID" value="L593_01215"/>
    </dbReference>
    <dbReference type="GeneID" id="16182365"/>
    <dbReference type="KEGG" id="sali:L593_01215"/>
    <dbReference type="eggNOG" id="arCOG03020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133603_1_1_2"/>
    <dbReference type="OrthoDB" id="114514at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10552" checksum="DBB8CF7FBE2301EB" modified="2013-07-24" version="1">MIPTATDAGIDDEQYPLTTQEFLERFGDVELELANGTERIGDALDRMDDETYESALDARFAVYAAVSHRAVGRRFYSDRDPTPPGSPHGPDQVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVP4</accession>
    <name>R4VVP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445220.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01875"/>
    <dbReference type="EnsemblBacteria" id="AGN00326">
        <property type="protein sequence ID" value="AGN00326"/>
        <property type="gene ID" value="L593_01875"/>
    </dbReference>
    <dbReference type="GeneID" id="16179976"/>
    <dbReference type="KEGG" id="sali:L593_01875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.380"/>
    <dbReference type="eggNOG" id="arCOG04309">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_2"/>
    <dbReference type="OrthoDB" id="71537at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="29330" checksum="34E9D05C5B39BC84" modified="2013-07-24" version="1">MLTLASDFGSPYPAAMRAAVRQYSDCEILDVAHDFPRQDVRTAAFWLREVLPYAPAPAVHCAVVDPGVGSDRAAVALRVGEHALIAPDNGLVVPAARRLRERMPAAGSGLRGVDPSPDGDEISAVAEPAAIEAFEIAVDDPASSTFHGRDVFAPAAALIHERGVASMETCSFLDPVDEFVDLQFPVPIERGDGADGEVLVVDGFGNAITNVPGDLLDGRDRIRVDGTAWPVADHYAAVDVGDGLVTVGSHGNVELAVNRGRGADRFEVGVGDDVAIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVU4</accession>
    <name>R4VVU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06890"/>
    <dbReference type="EnsemblBacteria" id="AGN01325">
        <property type="protein sequence ID" value="AGN01325"/>
        <property type="gene ID" value="L593_06890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06890"/>
    <dbReference type="eggNOG" id="arCOG02911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099716_0_0_2"/>
    <dbReference type="OrthoDB" id="81336at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="24282" checksum="D460DCE24FF70CB1" modified="2013-07-24" version="1">MVGLTVLALGGLTVAIGTVVDSSASNAEANRVADAMTVVAEPGDVVGTAEAELRFGDGSLRTENRTIRILDAANGTVIERVDSAVLVYTVGDWTVIGGNGAVLRAGSGGASMVESPSIVADPDPNGPLLLGVPAIDAEALSIDTDAAARVTFRASVTHDRRDLGSRRIRVVVETAYPDAWQRYFERNGATVIDRSRSFPSDGADAETSIVAEYAGPRQTYLVLHRTDLEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW18</accession>
    <name>R4VW18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02550"/>
    <dbReference type="EnsemblBacteria" id="AGN00461">
        <property type="protein sequence ID" value="AGN00461"/>
        <property type="gene ID" value="L593_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.517"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="21610" checksum="05892B8F56469686" modified="2013-07-24" version="1">MEQVFAPWRIEWIEREDRNEAIEECVFCELPAMDDDREHLIVARSEHAFVMLNNYPYSPGHAMVIPNPHGGDLRDLPDEVLLDHAKLKARTIDALEAAFDPAGFNAGLNLGGDAAGGSIDDHLHTHVVPRWSGDTNFMPVISDTKVIVESLEDTYDRLHAAFAAQEGASEATGAAKEGEDTDADQDRSAAVRIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW22</accession>
    <name>R4VW22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446309.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01415">
        <property type="protein sequence ID" value="AGN01415"/>
        <property type="gene ID" value="L593_07350"/>
    </dbReference>
    <dbReference type="GeneID" id="16181595"/>
    <dbReference type="KEGG" id="sali:L593_07350"/>
    <dbReference type="HOGENOM" id="CLU_2010185_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="14674" checksum="ABBA177862CBAA16" modified="2013-07-24" version="1">MQRRQFITSASATVAAASIAGCSGILGGGGGGNSGPDGPVKAYASAVSNNNADELQSLAHPDANESTGELSDSDLEGISMNVKSTEVLEQSDGQATVEAEIETTVTMMGEEQSQTQTIEFDVRKHDGEWLIYDSETVSTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWA1</accession>
    <name>R4VWA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445445.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03000"/>
    <dbReference type="EnsemblBacteria" id="AGN00551">
        <property type="protein sequence ID" value="AGN00551"/>
        <property type="gene ID" value="L593_03000"/>
    </dbReference>
    <dbReference type="GeneID" id="16182720"/>
    <dbReference type="KEGG" id="sali:L593_03000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.608"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_0_2"/>
    <dbReference type="OrthoDB" id="67791at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="150"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="31555" checksum="D982AA3C28072235" modified="2013-07-24" version="1">MRAIYATDLSAASEAAIENETCLECLERIGVDTFHLVTVIPSNVHAGMPGMRFEERREQALDRYSRVMEDAGFDVETHVVRGTPHRRINGVAESVRADLTIVGSRGKSPLENRVIGSTARNLARTTVVPLVVNRIEREAEQPDVLREHLFQRVLFATDFSENAERAFDSFSYLRHATQEATLVHVESPKDPIPEEAEPSPEERLDELAETLEQWDIETEIDVRRGDPSDEILAAEEEFVPTTTLVGSRGRSRMRRLLLGSTSEDIVARANGNVFLVPPPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWE2</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00601.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00601">
        <property type="protein sequence ID" value="AGN00601"/>
        <property type="gene ID" value="L593_03250"/>
    </dbReference>
    <dbReference type="GeneID" id="16180454"/>
    <dbReference type="KEGG" id="sali:L593_03250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.657"/>
    <dbReference type="eggNOG" id="arCOG00134">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641944_0_0_2"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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    </dbReference>
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            <end position="29"/>
        </location>
    </feature>
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            <end position="53"/>
        </location>
    </feature>
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            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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            <end position="413"/>
        </location>
    </feature>
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            <begin position="7"/>
            <end position="415"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="434" mass="43266" checksum="F7FF8DB1D8F93AC1" modified="2013-07-24" version="1">MNADRRVLAAVVASTFFVGFGGGVVFPILPNLGTVLGISPFLVGVILSTNRFVRLVANAPAGALVDRIGTRTPFVAGLAIEGVATTGYLLALWMDAAGPVGVAGVDVTAAEWWFILARVLWGLGSALVFATAYTIATDVSSGGSRGMDMGIVRGGILLGFPAGLVMGGVVSDLASVEAAFGIAAAFALFASVLAHVSVPETHVASERSSVKPWEVDTAIPTLTVGAVNFAVLFAYIGALFATLVLFLEAIDVGVFGLNAQGSSGVFMAVTVLAAAVSMLGGGKASDLSDSRVPILLGFLGVSVIGFLLLAAVDAGLFDGVVDPAVALVVGCVFVGAGQGGVSGPMTALLADLTPAERTGRAMGTNNVFGDVGGGLGPLISLPLIDVVGFGPIYAACAFLPAIAAVVLVVGVYAETGSVRPGTASVATPGPAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWG6</accession>
    <name>R4VWG6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08200</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01585">
        <property type="protein sequence ID" value="AGN01585"/>
        <property type="gene ID" value="L593_08200"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_08200"/>
    <dbReference type="eggNOG" id="arCOG04776">
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    </dbReference>
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    <dbReference type="OrthoDB" id="123698at2157"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9411" checksum="6E7AF6DEFC689627" modified="2013-07-24" version="1">MTPVPLQWMNDFLLAYNIGHAILVGFVLSVLAILPLQSRKVFALNAGLFGTLFVITPISASAYQWRLFGFVLLVLAPLLYLTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX41</accession>
    <name>R4VX41_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00831">
        <property type="protein sequence ID" value="AGN00831"/>
        <property type="gene ID" value="L593_04400"/>
    </dbReference>
    <dbReference type="GeneID" id="16180925"/>
    <dbReference type="KEGG" id="sali:L593_04400"/>
    <dbReference type="eggNOG" id="arCOG01731">
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    </dbReference>
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    <dbReference type="OrthoDB" id="52466at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="256"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="498" mass="51927" checksum="2570F513F0419B14" modified="2013-07-24" version="1">MSGDASEHSRRFTEGPIVWPLLALAGPLTLTQLLQVAYNLTDTFWVGRLGADPVTALSFAWPIVFLLVSLGAGMTNAGTILVAQHSGAGNDDRLGHVTGQTMAFNAVLSVVVAAFGFVFAPYLLQAIGATPGTAVHEQATTYLRIVVLGMPFTFGFHVFMAVLRGWGDTKTPMYLMVFSVGLNVLLDPFFVLGFADNPLFGWLGLQGLQTTLYGATGFGGLGVAGAAVATVLSRGLAALVGAWLLFGGYVGLRLALEDLVPSRETIEQIVRIGTPGAIDQSTQSIAAIVMTALVATVGQDAVAAYGIGNRFVSVVWLPMAAMGMSVETIVGQNLGGGHRDRARRTVYVAIAILATTFVVASALTVTFADSIVGVFITGDGSAAVVDHGATFLRIVAPAWAIMAVYHMMNGAFYGAGSTRLAMSIGVSSLWGVRAIAAIVLVLLLGFGATGAWIAIALSNVTAALVGTYWFFDGRWMHDVLGDAATEQDGPGERSGATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX50</accession>
    <name>R4VX50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446694.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09275"/>
    <dbReference type="EnsemblBacteria" id="AGN01800">
        <property type="protein sequence ID" value="AGN01800"/>
        <property type="gene ID" value="L593_09275"/>
    </dbReference>
    <dbReference type="GeneID" id="16182666"/>
    <dbReference type="KEGG" id="sali:L593_09275"/>
    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922879_0_0_2"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="3">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="13997" checksum="C9A8EE5F6748491F" modified="2013-07-24" version="1">MTAPQTDGGDRPAGATDPSYEEWRRSLWEDETILGQRCGDCGHATAAPKAACARCGSRDLDRIELPTEGEVWARTRIEIAPADFDGPYTVALVDLGEAKVLARLTDEFAIGDSVALTDVYEGDLGPAPVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX51</accession>
    <name>R4VX51_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="8">PRA-PH</shortName>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisE</name>
        <name evidence="9" type="ORF">L593_04450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445735.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04450"/>
    <dbReference type="EnsemblBacteria" id="AGN00841">
        <property type="protein sequence ID" value="AGN00841"/>
        <property type="gene ID" value="L593_04450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180942"/>
    <dbReference type="KEGG" id="sali:L593_04450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.907"/>
    <dbReference type="eggNOG" id="arCOG02677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123337_0_1_2"/>
    <dbReference type="OrthoDB" id="110768at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10810" checksum="4A80D35FC33C3C04" modified="2013-07-24" version="1">MTEPVLDELFDVIEARKAELPEDSYTASLFTHEKGQNAVLEKLGEETTELVLAAKDDDTEEIAHESADIVYHLLVLLSMHDMDLADLRAELRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX87</accession>
    <name>R4VX87_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446739.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09500"/>
    <dbReference type="EnsemblBacteria" id="AGN01845">
        <property type="protein sequence ID" value="AGN01845"/>
        <property type="gene ID" value="L593_09500"/>
    </dbReference>
    <dbReference type="GeneID" id="16180423"/>
    <dbReference type="KEGG" id="sali:L593_09500"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_8_1_2"/>
    <dbReference type="OrthoDB" id="97752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="12427" checksum="59766A8AD6FE4C00" modified="2013-07-24" version="1">MQLNELTRFTDDVEAVSAFYESLPGATEVAAGEGISIVSVGDLTVLVHEEYEAEGDDLPPDDHVSFEVENLDATVADLRNAGLEIARGPETYDWGRSAYLRDPDGRQIEIAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXF9</accession>
    <name>R4VXF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04985"/>
    <dbReference type="EnsemblBacteria" id="AGN00946">
        <property type="protein sequence ID" value="AGN00946"/>
        <property type="gene ID" value="L593_04985"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04985"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045504_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="455" mass="50134" checksum="4F579F6BB2EBEE72" modified="2013-07-24" version="1">MEARMNVKRRLVAALPPTVKRLLARPYDLVQTKRANRTFRARDRPSIDPDPDAPQHVVLLVVDALRSDVVTEETMPFLASMDGTTSALTPSPWTFPAVSSMLTGAYPHEHGAIRAPNVADEGFVLPERIPDDRLTLSDYFAAAGYHTYGGFGHDTPFVALSGRFATHDLSHQLDASAADVLADHEQWITDRSNSPTFSYVHLADPHIPVTPPNEYWQKYDVDSSIENLENWEYERTLEPDEAAERYREHRWRLYRAAAEYVDDCISAHIESIRSILDDVTIVVTADHGELLWDHVALDQEQFFGDGCVDHGGTPYEALARVPLLSDELPTAPNDGSPASLIDLAPTLLSSIGVDAPEGTSGLDLHADDHNPRSLLVEGCLGPEERKAVYSDGDKLIASESGTTLTFDLPDETPVEFDSASTETLRSKLPPWPDSDIGSTNVSGVVENRLDALGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXK8</accession>
    <name>R4VXK8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446884.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10225"/>
    <dbReference type="EnsemblBacteria" id="AGN01990">
        <property type="protein sequence ID" value="AGN01990"/>
        <property type="gene ID" value="L593_10225"/>
    </dbReference>
    <dbReference type="GeneID" id="16180919"/>
    <dbReference type="KEGG" id="sali:L593_10225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2107"/>
    <dbReference type="eggNOG" id="arCOG02408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092340_3_0_2"/>
    <dbReference type="OrthoDB" id="78441at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="164" mass="18109" checksum="FD545D4BF1C7127E" modified="2013-07-24" version="1">MTTHPGQRVAVLADAQNLYHTAQSLHTRNVDYAALLERAVDDRELVRAIAYVIRADAPEEESFFEAVEEIGFEPKIKDIKTFGDGSQKADWDVGISLDAVTLASHVDTMVLCTGDGDFARLCSHLRHEGVRVEVLSFEASTAEELIDATDEFVDLGGDPDRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU7</accession>
    <name>R4VXU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05710"/>
    <dbReference type="EnsemblBacteria" id="AGN01091">
        <property type="protein sequence ID" value="AGN01091"/>
        <property type="gene ID" value="L593_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1169"/>
    <dbReference type="eggNOG" id="arCOG01680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="162" mass="17411" checksum="A90C78D1AECB16BE" modified="2013-07-24" version="1">MATASDRLRRYLDDELGECRDEDVERRLDELGTLEAALGTARVDAELDVLSALANETRYTLVRVLVAAEEELCVCELNAVVDVSESGLSHALSALVDAGLLEGRKDGRWKKYSATNRAVALVTVIEGSVGAVEERGDDGEARADGESEQQNGESDRTGGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXY1</accession>
    <name>R4VXY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446015.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01121">
        <property type="protein sequence ID" value="AGN01121"/>
        <property type="gene ID" value="L593_05860"/>
    </dbReference>
    <dbReference type="GeneID" id="16181513"/>
    <dbReference type="KEGG" id="sali:L593_05860"/>
    <dbReference type="eggNOG" id="arCOG02967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878851_0_0_2"/>
    <dbReference type="OrthoDB" id="102157at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="34489" checksum="B7D8CC9B74C8FCB0" modified="2013-07-24" version="1">MTEQSPPEPPEDEQILTTARERPGQVDVEALVEVLDADEGQARNEALMALGRVADYDADMVVEYTDEFIESLNDGFPVAESSAAQVLSRIANEYPEEVRPAIPRLIEMLDQIPPLTGYRAGRTLAPLLAEFPEDFVSEADQLIDVVNDPQDASVPTEEDYERMDNEERAKTEDRLQSRAQQARADVARSFGIREIAANSLVEVSERAPEAVAPRIEDLTPALFTDPPIAQAATIDTIANIAQHDPDAVDPVVDDLIEVTQTQVNSIRAHAIQALGHAGATEAADPLRELAASDDPELTEELQDLAAETADFLEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY19</accession>
    <name>R4VY19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11075"/>
    <dbReference type="EnsemblBacteria" id="AGN02160">
        <property type="protein sequence ID" value="AGN02160"/>
        <property type="gene ID" value="L593_11075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11075"/>
    <dbReference type="HOGENOM" id="CLU_2140309_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="12021" checksum="EA0AAEE1C1E6275E" modified="2013-07-24" version="1">MNGRAGERVAGIPGDIDLEPPRASNRFQPRSLLPGCPSPVLVDRSGRRDQNDFVCTVVTRHVMVDPNGPLAWGFFVLAALFLFAVMGVDLVSVVIVGLFTLGAMGYYGRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY45</accession>
    <name>R4VY45_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">L593_11200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447079.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11200"/>
    <dbReference type="EnsemblBacteria" id="AGN02185">
        <property type="protein sequence ID" value="AGN02185"/>
        <property type="gene ID" value="L593_11200"/>
    </dbReference>
    <dbReference type="GeneID" id="16182036"/>
    <dbReference type="KEGG" id="sali:L593_11200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2310"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OrthoDB" id="108717at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="181" mass="19953" checksum="838FE29D24BFE4C1" modified="2013-07-24" version="1">MATGPRYNVPMRRRREVRTDYHQRLRLLKSGKPRLVARTSNGHVRAQLVTTGPDGDETVVSAHSADLAEYGWEAPTGNLPSAYLTGLLAGTRAVDEGIEEAVLDIGLNSPTPGSKVFAIQEGAIDAGLEIPHNEAVLPDWERNRGEHIAEYAEQLDEPLYSGEFDAADLPEHFDELREELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY59</accession>
    <name>R4VY59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="13" type="ORF">L593_06210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446085.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06210"/>
    <dbReference type="EnsemblBacteria" id="AGN01191">
        <property type="protein sequence ID" value="AGN01191"/>
        <property type="gene ID" value="L593_06210"/>
    </dbReference>
    <dbReference type="GeneID" id="16181812"/>
    <dbReference type="KEGG" id="sali:L593_06210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1268"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OrthoDB" id="25871at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="96"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="11">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="471" mass="50995" checksum="D0C3D371795FA63F" modified="2013-07-24" version="1">MVLDDLGSSLRSTLDNLRGKGRISEEDVDEVVREIQRSLLQGDVDVALVQELSDSIKERSLEEEPPAGTSAREHVLRIVYEELVGLVGESTDLPLEDQTILLAGLQGSGKTTSAAKMAWWFQTKGLQPAVIQTDTFRPGAYDQGKEMASRAEVDFYGDPDGDDPVKIARDGLEETADADVHIVDTAGRHALEDDLIAEIEEIEAAVDPDRSLLVLDAAIGQGAKDQARQFDESIGIDGVVITKLDGTAKGGGALAAVDQTDSSIAFLGTGEGVKDVERFEPDGFISRLLGMGDLKQLAERVERAMEETGLEEDDDWDPEDMLEGQFTLRDMQKQMEAMNKMGPLDQVMDMIPGMGGGMMDQLPDDAMGVTEERMREFEVIMDSMTDGELENPRSVGQSRTERIARGSGTSEERVRELLQQHKMMEQTIKQFQGMGDADMQRMMKQMEGGGGPGGGMGGMGGGGPGGNPFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY97</accession>
    <name>R4VY97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447119.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02225">
        <property type="protein sequence ID" value="AGN02225"/>
        <property type="gene ID" value="L593_11400"/>
    </dbReference>
    <dbReference type="GeneID" id="16181205"/>
    <dbReference type="KEGG" id="sali:L593_11400"/>
    <dbReference type="eggNOG" id="arCOG08144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2713014_0_0_2"/>
    <dbReference type="OrthoDB" id="121637at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="8385" checksum="0EA4D99E07A7AC4E" modified="2013-07-24" version="1">MTMALEAEWEAAPDDPHPERDLGYHGATWEVISVEQRGSEHKLFLPPEEECLWREEFVIAEAELVRDLHDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYB4</accession>
    <name>R4VYB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447139.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11510"/>
    <dbReference type="EnsemblBacteria" id="AGN02245">
        <property type="protein sequence ID" value="AGN02245"/>
        <property type="gene ID" value="L593_11510"/>
    </dbReference>
    <dbReference type="GeneID" id="16180166"/>
    <dbReference type="KEGG" id="sali:L593_11510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2373"/>
    <dbReference type="eggNOG" id="arCOG04430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_3_1_2"/>
    <dbReference type="OrthoDB" id="11161at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="409" mass="45346" checksum="069DE19D772846BE" modified="2013-07-24" version="1">MKTIKDSVHDHIDVQGIARALLDTPALQRLRRISQLGTVSLVYPSANHTRFEHSLGVYHLADRALAHLPARQQRAKRVRAAAILHDVGHAPFSHNVEELLARRTGTYHDEVHDRLDSGEVGDVLREYDVDPAEVADLVAGEGRYGQLVSGELDVDRMDYLVRDAHHTGVPYGTIDHSRLVRELTFRDNRLVLGEGNVQTAESLLIARALMNPTVYRHHVARISKSMLRRGTEALIDEGEIDAEAVSEMDDPELLVALRNCEPAAIYARRLDDRELFKRAVWAELEDVPEHVVDADHETVRELEGQIARKASVPEEAVILDVPERPSMPESSSRVVVNGEVRPLAEQSPLVEALRAAQHSQGRLGVYAPQTRTEAVGPAAVDVLGIDVDDVLVTEVRGYPATLSEFTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYN2</accession>
    <name>R4VYN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447264.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12135"/>
    <dbReference type="EnsemblBacteria" id="AGN02370">
        <property type="protein sequence ID" value="AGN02370"/>
        <property type="gene ID" value="L593_12135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180473"/>
    <dbReference type="KEGG" id="sali:L593_12135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2497"/>
    <dbReference type="eggNOG" id="arCOG01963">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057266_0_0_2"/>
    <dbReference type="OrthoDB" id="50594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="403" mass="43208" checksum="88A94BEE3D20A07A" modified="2013-07-24" version="1">MTLDGDDPRSEPVEYEPVSVKDVLVEMKDTSELLIDLAYSAVLHNSDAIAEEVLRLEEQMDVLEIRARMSIMMAARNPSETEVLAPVLGVVGGAEKISDAAGDVAKIVLGDMGLPDAMRAALPEAFEPLERATVTSDSPYASRTLGEIDLESETGVRVIGIRRGEDWFLNPGPNTGLAADDVALIRGPDHAIDDVYETIADEGYESHAEPEPAIDDLDRAVDSIVHMKNLSELAVDLAYGSVLFDDAALAEEVRNLEVEVDALQSRFEAWTLGAAAEAEDPVTLRGLIRLGFATETISDAALEISEGVLRDIDVHPVVELAVRESDEVLTRIEVEAGSALAGEELREGVPAVGPSTTVIAIRRPEVGWVLVGQSHEVLQAGDVLIAKGTRTAADSFKTLARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYT7</accession>
    <name>R4VYT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446300.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01406">
        <property type="protein sequence ID" value="AGN01406"/>
        <property type="gene ID" value="L593_07305"/>
    </dbReference>
    <dbReference type="GeneID" id="16182091"/>
    <dbReference type="KEGG" id="sali:L593_07305"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118249_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator_TrmB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="26566" checksum="C3D0B25E0D0F5898" modified="2013-07-24" version="1">MFPGESTELSCVSDPGDALDRVRSLLDGAEHSAVVSIHEAYLDAIRPELEAARDRDALVVLLVYDCHTVVDPVTDFEPIASIARQTERIVPMYCVVDDLHGLYGDPELLVADDPALRASIVHNRDIAYALYGHLVGNYWRAGVETHSPEPPALPVSSDDVRGLVIDAAVHLRQATPIVATVEPVPSEDRDEIEGPVIDATQALLSPADSAVSLQSTLVLRTDTGRTTVGGPGAYLEDVKAVSGTLRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYW0</accession>
    <name>R4VYW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447344.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12555"/>
    <dbReference type="EnsemblBacteria" id="AGN02450">
        <property type="protein sequence ID" value="AGN02450"/>
        <property type="gene ID" value="L593_12555"/>
    </dbReference>
    <dbReference type="GeneID" id="16180036"/>
    <dbReference type="KEGG" id="sali:L593_12555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2577"/>
    <dbReference type="eggNOG" id="arCOG04580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559761_0_0_2"/>
    <dbReference type="OrthoDB" id="27913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="491" mass="53962" checksum="4CC78218B8334B53" modified="2013-07-24" version="1">MPDREAIRSNAKYLRNVRPLDPEEISEYVEGGPHPAVVRQVLREESFDLGIVEREDGTFVPVEEGTIDPPRLPVTEFPESYATRLEELLVDAFGQDWHLGESGNDLRDAIRDLKEAYHRGWSVTYDDETAALAYALYHLPDYYAAVQYPVAELAEIGLLDRQLRILEVGAGTGGPALGIADAVPDDALVRYDAIEPSASADVFEAMVEDAGDHVDFEVHRTTAEDFAFDAAGEPGTPEYDLVLFANVLSELDDPVATAKRYTDLVADDGAMVLLSPADRRTTGVLRGVERALADGTKPQGIGDVSDLPSGDERATVFSPTVRLWPNWTPADEGWSFAVRPDIDVPAFQRRLDEPAGAEGEFVNVDVQYAYATLRWDGERRVAFRPDRGDWAPLAESEKHVSDRVDCAAIKLSADLSEGGHPLFRIGDGSQQVDHFAVLTKETSLNRSLATAGYGDLLTLESVLVLWNDDEQAYNFVVDDETIVESVAAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYY1</accession>
    <name>R4VYY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447364.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02470">
        <property type="protein sequence ID" value="AGN02470"/>
        <property type="gene ID" value="L593_12655"/>
    </dbReference>
    <dbReference type="GeneID" id="16181866"/>
    <dbReference type="KEGG" id="sali:L593_12655"/>
    <dbReference type="HOGENOM" id="CLU_1088275_0_0_2"/>
    <dbReference type="OrthoDB" id="110213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="255" mass="26152" checksum="43E3F44DA496AEF6" modified="2013-07-24" version="1">MQRRAFLAGAVGIAGGLAGCSDVLPGSGDSNDGGDDGPAGAVRGLYEAAFSGDVEEANAYIHSEADLDPLTQSQADSFQAVDARVESVEVVEQSGDTATVQARLSAVPDDSSERQTLPSIRLELRTENGEWKVYDDASADDAPVAPRVQWESSERTDADGSVTAVTFTHAGGDTVPSGTLSVRASGSTASAPNGTDVTAGTTLVVPTEGRGNSMAASTDILLGWSNPDDGSSQILAEHTLTSPTVGTLAERLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ41</accession>
    <name>R4VZ41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446410.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07855"/>
    <dbReference type="EnsemblBacteria" id="AGN01516">
        <property type="protein sequence ID" value="AGN01516"/>
        <property type="gene ID" value="L593_07855"/>
    </dbReference>
    <dbReference type="GeneID" id="16182277"/>
    <dbReference type="KEGG" id="sali:L593_07855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1609"/>
    <dbReference type="HOGENOM" id="CLU_204972_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6760" checksum="801769354A4987A0" modified="2013-07-24" version="1">MFGRRGKIDVETLLKIVLVLLIVILALQLIGYFVDLVVGIAGNVIVLILILLLVLYLLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ94</accession>
    <name>R4VZ94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13280"/>
    <dbReference type="EnsemblBacteria" id="AGN02595">
        <property type="protein sequence ID" value="AGN02595"/>
        <property type="gene ID" value="L593_13280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13280"/>
    <dbReference type="eggNOG" id="arCOG06150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118250_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="24670" checksum="32E29CB2F407AF62" modified="2013-07-24" version="1">MIAAAVIVVLLAGLALVGPALAGDAVAQFDFGEEERTASPGETVTVDVVLRSDGGYAGEGIESYSFVVAVPPEVGEPTSVEAGPWLARDGGSVEQTVTDAGEGAIRVRHEQADAEDGVTGAGVAATVTIELREDAPASDATVLIADPDAQLHGSDFPMRSLGDEATIVVDGGGEQLEPAYQPGDRSGDGVDVTTANETNRTPESGDDAGAETDGGGANSGDDSLPGFGLGASILALGVLAAVAGAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZC2</accession>
    <name>R4VZC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">rpl37e</name>
        <name evidence="12" type="ORF">L593_13430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447519.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13430"/>
    <dbReference type="EnsemblBacteria" id="AGN02625">
        <property type="protein sequence ID" value="AGN02625"/>
        <property type="gene ID" value="L593_13430"/>
    </dbReference>
    <dbReference type="GeneID" id="16180684"/>
    <dbReference type="KEGG" id="sali:L593_13430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2747"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OrthoDB" id="124429at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="56" mass="6195" checksum="84B5067AD1CB7677" modified="2013-07-24" version="1">MTTGTSAEGKKNKTTHVTCRRCGEASYHTGKERCSSCGFGTSSKRRDYEWQSKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZE4</accession>
    <name>R4VZE4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">hisB</name>
        <name evidence="6" type="ORF">L593_08405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446520.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08405"/>
    <dbReference type="EnsemblBacteria" id="AGN01626">
        <property type="protein sequence ID" value="AGN01626"/>
        <property type="gene ID" value="L593_08405"/>
    </dbReference>
    <dbReference type="GeneID" id="16182393"/>
    <dbReference type="KEGG" id="sali:L593_08405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1722"/>
    <dbReference type="eggNOG" id="arCOG04398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_2"/>
    <dbReference type="OrthoDB" id="91418at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="21093" checksum="9874B2FA01A7A03B" modified="2013-07-24" version="1">MSDRAAAVSRETAETDIDLTLEIDGDGEAEVDTGIGFFDHMLEALATHGLFDLTVSCDGDLEVDDHHTVEDVGIALGEAFDEALGERERIVRYADRRVPLDESVASVVVDVSGRPRFYFEGTFSQAAVGELASDMARHFFESLALNAGLTLHAEIEGRNAHHEIEALFKAVAGAMDDATRIDERRSGAPSTKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZH2</accession>
    <name>R4VZH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446545.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01651">
        <property type="protein sequence ID" value="AGN01651"/>
        <property type="gene ID" value="L593_08530"/>
    </dbReference>
    <dbReference type="GeneID" id="16182804"/>
    <dbReference type="KEGG" id="sali:L593_08530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1746"/>
    <dbReference type="eggNOG" id="arCOG04570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090976_1_0_2"/>
    <dbReference type="OrthoDB" id="90597at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="185" mass="21173" checksum="18BB0D2ED8EF0111" modified="2013-07-24" version="1">MSETPPGWADELRASRAEKDEFLDTHRQSPIPPEKRDEFDGLAYFEPDPEYRVEAEVTVHDEPEQLELDTSDGRSVRYDRVVTFDFELNGNDVELHGYQQPDEDLAEAPIFVPFRDKTTGPVTYDGGRYMDLATERALETGDVIPLDFNLAYSPFCAYSETFSCPLPPEENWLEVAIEAGEKDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZH5</accession>
    <name>R4VZH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447564.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02670">
        <property type="protein sequence ID" value="AGN02670"/>
        <property type="gene ID" value="L593_13655"/>
    </dbReference>
    <dbReference type="GeneID" id="16182248"/>
    <dbReference type="KEGG" id="sali:L593_13655"/>
    <dbReference type="eggNOG" id="ENOG502N62S">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379547_0_0_2"/>
    <dbReference type="OrthoDB" id="130293at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="10951" checksum="5DBF2EBAC0C802B9" modified="2013-07-24" version="1">MSEGTVTVGPRVEFALDGYVRIRAYSPELGRDCYVYVQRLTGFASGELDSPWITDDPRHADHRNGEKWDNRPENIRGEWPDDHGRRHRRQQLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0C3</accession>
    <name>R4W0C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02965">
        <property type="protein sequence ID" value="AGN02965"/>
        <property type="gene ID" value="L593_15155"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_15155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3095"/>
    <dbReference type="eggNOG" id="arCOG02911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029417_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="48387" checksum="FFFD76858B4BD4B8" modified="2013-07-24" version="1">MALFLAGMTLAESTQSSAVDQQAEQSMAQLAASADDIASGEAESSAFAIRGADTAQVRGIPDAGQINVTVTNRSTGKQIFTIEEPLGAVVYETRDGTEIAYQGGGVWRRSPNGYSQLVRAPEFHYRERPDPTITFPITLMRSEFSQSGDVDGQLRARESIRRYPDQPNHFNPLQDGSVLITIDSRYCSGWENYFDHYTDGSPAEGCDDGTEDQLVIQFSVPFQLDGLGSGAMLDGGSGDPSNFGGINDSSEFGDSDDAPSATPMVESKLEEARSSGQVLPDDAVIDDAGLYYADGNLSSGDVTFDTTDGDIEVASDQYPVVDGNVSIEGDGNVTLYISRNLVDKGGGNEQIGDPENTSQLRVFVHSEVDQVGHKGQNSDFHGLLYAPNSEVLLFRGNNNASGALVAEDVDFGSTVFDLDPELANMSFYEELGDAPFYYLHISETTIEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0T7</accession>
    <name>R4W0T7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="8" type="ORF">L593_11130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447065.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11130"/>
    <dbReference type="EnsemblBacteria" id="AGN02171">
        <property type="protein sequence ID" value="AGN02171"/>
        <property type="gene ID" value="L593_11130"/>
    </dbReference>
    <dbReference type="GeneID" id="16180794"/>
    <dbReference type="KEGG" id="sali:L593_11130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2296"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OrthoDB" id="103467at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="17051" checksum="144CE0F10A2983E8" modified="2013-07-24" version="1">MGISYSVDADPDTTAKAMLRERQMSQKHSKAIAREIKGQTAEDAVAYLEDVVAGEQSVPFREHNSGVGHRSDIDGWDAGRYPEKASEGFLDLLENAIANAEHQGFDGETMEIVHVASHKVGETQGRKPRAMGRAGAWNSPEVDVEIVLAESTDDGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W288</accession>
    <name>R4W288_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase RIL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447660.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14135"/>
    <dbReference type="EnsemblBacteria" id="AGN02766">
        <property type="protein sequence ID" value="AGN02766"/>
        <property type="gene ID" value="L593_14135"/>
    </dbReference>
    <dbReference type="GeneID" id="16181094"/>
    <dbReference type="KEGG" id="sali:L593_14135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2892"/>
    <dbReference type="eggNOG" id="arCOG00187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OrthoDB" id="13010at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="76"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="355"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="610" mass="67987" checksum="E944C6D44784B057" modified="2013-07-24" version="1">MSDDSIAVVDLDRCQPDRCNYECKNYCPPNRTGKECITLRGEDADEGDPDQVRISEEICLGETCGICVEKCPFDAIEIVNLPSELEEDPAHRYGENAFRLYGLPAPESGNVVGILGPNGIGKTTAIKMLAGELVPNLGHYDPDADVGWDDVLDAYRGTELQDYLAAIRDDDVSVSRKPQYVDRIPDQFDGNTRQLLEGTNERCVLDDLVEALSIGPVMDQSIDALSGGELQRVAIAACLARDADFYFLDEITPYLDIGQRMAAARLLRDTLEDEDRSMLVVEHDLAILDLLADTLHVAYGRPGAYGVVTDPKSVRNGINEYLSGYLENENMRIRPEAIQFEEHAPRTVSRSETLVEYPEMTMSYGDDAFSLEVDAGKIRENEVLGIVGPNGIGKSTYAKLLTGQLQPDEGSIDADLDISYKPQYIEIDRQQRVDTFLRGITDQFGSSYWNTEIAQPLQLDRIMEQQLTDLSGGERQRVAIAACLSEPADLYLLDEPSAHLDVEQRVQATSAIRRYAEQQDATVLVIDHDIYMIDLLADRLQVFDGEPAVHGHAGTPQGMRSGMNEFLSNLEITFRRDERIGRPRINKPGSQLDRQQKREGEYYYAPADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2G8</accession>
    <name>R4W2G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444856.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00035"/>
    <dbReference type="EnsemblBacteria" id="AGM99961">
        <property type="protein sequence ID" value="AGM99961"/>
        <property type="gene ID" value="L593_00035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180613"/>
    <dbReference type="KEGG" id="sali:L593_00035"/>
    <dbReference type="eggNOG" id="arCOG04124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_2_2"/>
    <dbReference type="OrthoDB" id="127137at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="7121" checksum="AE0ED395939AD910" modified="2013-07-24" version="1">MKQSTLDILRCPLDKAELDLDVEEQDGEEILEGTLTCTDCGETYHIEDGIANLLPPDMREEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W360</accession>
    <name>R4W360_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Isopentenyl phosphate kinase</fullName>
            <shortName evidence="6">IPK</shortName>
            <ecNumber evidence="3 6">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_01905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01905"/>
    <dbReference type="EnsemblBacteria" id="AGN00332">
        <property type="protein sequence ID" value="AGN00332"/>
        <property type="gene ID" value="L593_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.387"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="259" mass="26066" checksum="0DC4CEE019E4CD5A" modified="2013-07-24" version="1">MVAVTAVLKLGGSVVTDKDRPETLDGPALDAAAAAIGEVAASVRPSDPESLEPADLVVVHGGGSFGHHHAEAHGVSTTSGTHDPEAVLAIHGAMTTLNRFVVQRLREQQVPAVPVHPSSAGHRNSAGDLTLPAGQVATLLGEGFVPVLHGDGVAHVGEGVSVLSGDEVVVSLAESLGAERVGVCSTVPGVLDEQDDVVDRIPAYDAVEDLLGGSEATDVSGGMAAKVRELLALEGTASIFGLDDLPAFLAGDRPGTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W372</accession>
    <name>R4W372_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445246.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02005"/>
    <dbReference type="EnsemblBacteria" id="AGN00352">
        <property type="protein sequence ID" value="AGN00352"/>
        <property type="gene ID" value="L593_02005"/>
    </dbReference>
    <dbReference type="GeneID" id="16180022"/>
    <dbReference type="KEGG" id="sali:L593_02005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.408"/>
    <dbReference type="eggNOG" id="arCOG06507">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_1340716_0_0_2"/>
    <dbReference type="OrthoDB" id="63856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="24720" checksum="753D028015510DFA" modified="2013-07-24" version="1">MDSHEVRREWAERSGEYSPDYYAYYGPDETSESVRSIADRLTGPDPAILELGCSSGRHLAHLLEHGYRDLTGIELNGDAFDVMADAYPDLAADGTFYHDSIEAVVEAVPDDRFDLVYSVETLQHLHPDATWVFDELARITCGHLVTIENEGDDQESPPGDADPVEGVSYVNDEFPLYYRDWDRIFTERGLESVPVTDDERSVVHGVDTVRAFRSVATVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W376</accession>
    <name>R4W376_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00357.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG00302">
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    <dbReference type="OrthoDB" id="81816at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="34932" checksum="4AD21B82A8B1AB75" modified="2013-07-24" version="1">MRTLRLNPYADVDWDAVERHKAQLHAHTAHPPTNGHSGRDPPETVIDDYADAGYSVLALTGHEYAIDEPTWPWTDWDRSPEDLGMVAIRGAELGGSEEGLDRDLLSYFSGLADTSGMTVADALQEIGDREGLAVFPHPGRYPETAEWYVEHFLANPHLLGVEVVNAADRYPTDRDVWDALQELLGNERPVWGFANDDYHGRDAGYTFDGSRNVCYLEELTEASVREALVEGRFVYQHVEVDAPPILDSVEHDPDRGVLSVAARGWEEIQWASDGAVVERGPALHYRDVDGVGEYVRARLVAPGGSETGTQPFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3N7</accession>
    <name>R4W3N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445536.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03455"/>
    <dbReference type="EnsemblBacteria" id="AGN00642">
        <property type="protein sequence ID" value="AGN00642"/>
        <property type="gene ID" value="L593_03455"/>
    </dbReference>
    <dbReference type="GeneID" id="16180547"/>
    <dbReference type="KEGG" id="sali:L593_03455"/>
    <dbReference type="eggNOG" id="arCOG01072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147343_0_0_2"/>
    <dbReference type="OrthoDB" id="112817at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15962" checksum="7C4EEC51AE2200EC" modified="2013-07-24" version="1">MDEFAYVVNVDVAVHRDDEYLFIERGADEEHAAGLLGFPGGKLESDPGTADAIEATAIREVEEEVGVVVESPSYVHSSTFTADEGTTCLNVLTRVAYVEGRARPCAGEEVDAVHWLTPSELAGLDGVPSFTRTYLERVEADRDAATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W497</accession>
    <name>R4W497_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps11p</name>
        <name evidence="4" type="synonym">rps11</name>
        <name evidence="7" type="ORF">L593_05240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445891.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05240"/>
    <dbReference type="EnsemblBacteria" id="AGN00997">
        <property type="protein sequence ID" value="AGN00997"/>
        <property type="gene ID" value="L593_05240"/>
    </dbReference>
    <dbReference type="GeneID" id="16181288"/>
    <dbReference type="KEGG" id="sali:L593_05240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1070"/>
    <dbReference type="eggNOG" id="arCOG04240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_1_2"/>
    <dbReference type="OrthoDB" id="114285at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="13486" checksum="43182948990D8A06" modified="2013-07-24" version="1">MADNDDKWGIAHVHASFNNTILTVTDLTGAETIAKSSGGAVVKQNRDEASPYAAMQMAEEIGEEVQEAGFEGVHVRVRGPGGNLQKSPGPGAQATIRALARAGLEIGRIEDVTPIPHDGSRPPKGKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4E6</accession>
    <name>R4W4E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445976.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05665"/>
    <dbReference type="EnsemblBacteria" id="AGN01082">
        <property type="protein sequence ID" value="AGN01082"/>
        <property type="gene ID" value="L593_05665"/>
    </dbReference>
    <dbReference type="GeneID" id="16181486"/>
    <dbReference type="KEGG" id="sali:L593_05665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1160"/>
    <dbReference type="eggNOG" id="arCOG00239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_4_2"/>
    <dbReference type="OrthoDB" id="95156at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="24584" checksum="A2C63E03B84898A6" modified="2013-07-24" version="1">MIRTGTRTVADGATIRTVTFDRPERRNALTPKGLDQLEAAVTDATEPVVLLRGDGDAFCAGADLDVVDALPDRDAAKAFAEHGQRVATAIAAADPLVVAGIDGAARGGGLELALACDLRIATPTATLGEPGVELGLFGAWGGTIRLREVCGLGDAMDLACSGRVLDAEDALRIGLVSRIVDGEQGIVEVAEELASVDPDALRTVKRRLRDDADRATQEASEAAAFADLVVARTDGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4J6</accession>
    <name>R4W4J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446066.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06115"/>
    <dbReference type="EnsemblBacteria" id="AGN01172">
        <property type="protein sequence ID" value="AGN01172"/>
        <property type="gene ID" value="L593_06115"/>
    </dbReference>
    <dbReference type="GeneID" id="16181701"/>
    <dbReference type="KEGG" id="sali:L593_06115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1250"/>
    <dbReference type="eggNOG" id="ENOG502N5JF">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300290_0_0_2"/>
    <dbReference type="OrthoDB" id="1126at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="997" mass="114079" checksum="69237A66329FCF2B" modified="2013-07-24" version="1">MSSETASSSPDDLFCPHFHEKDESDLRSLFSRVAAVRAENPDLFWFTHRPIELFQIEGGVEGPSLETDEERVVTEDDVYQDFSGSRNKNFAVVIEGEVGTGKSELCVALNHRLENDADRPILRVNKDTDLMSMLTEDIPDFYQDHFDETLETSSRFKRLEDDIKQRPRMVASQAVYTALLEIGWDGYATSTTPDQEDAIVEFVAERIRDRLVEPRQYGDEPNLVTEQEYEQNSYLQVFDEGADAFEGHPAEKLSSGFWQALLDQYDTPPLTDLLEEVGEKFKEEYGDKRPVAVFEDFSITGMQARQLRNFMERDNPGDNWDFIVAGTRDSTAILHKRTAEDRFRFYRTNKQNSNQVLFLDDETAVDFIRPYLGYIKHHDGSVRYDRDAGDFTLLDPEPDSLCARCGLCDDSFRDLFPFNQQFIERIYTGLDESEQSPRELIIVVFETVLEYFNGTATCPATASPLNHVTNRVAAHDDVYQEAEVFAHVAKWYGDTDRYDEYIAVDRAFLEAFGLLPENPAADELPANIELLDDHVKIPGVEYIPPNDEETEPGETGEDEEETGGDDEETEGGGDGGGLSRIERLINEQSGYVDNWYANPQDESYVETDTYLRTAFADLINTLTQDYSLWTDCDLRYNLSRSDDPFVYPSAESSPAPGQIVLGPQDFQRSDIRELLKYGIRIDEADASADEQRVLTLVGGQLTEYARQWRAKVREQYIEDTSVYYKYDPPYGFDDYVLAAYAWIVVLDDPWQEVTAPTLNERFASGEDYALDTTLETALTEELAPEALDHIQEFMEYAEAFDALVAERHAINDTTLDLPRLRRWFSNNEPQDVLSRLRADPEGLSSRVRFDSDTKLVEMVTKAYRMQKSLDQQEDQIQDYTTARTAQNELGGIDMERIHDNVDVLDNYEVDRSLYESLLQFDSYSQAEVDEVVAASRLCLDTLGTSTQDAIHKMLVEYKLIEHEVIESFNEIDFETEESSSSFAPYFQEVSQYYVGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4V1</accession>
    <name>R4W4V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446241.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07000"/>
    <dbReference type="EnsemblBacteria" id="AGN01347">
        <property type="protein sequence ID" value="AGN01347"/>
        <property type="gene ID" value="L593_07000"/>
    </dbReference>
    <dbReference type="GeneID" id="16181961"/>
    <dbReference type="KEGG" id="sali:L593_07000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1431"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_2"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="369" mass="40960" checksum="7B06FCAE2AF7A185" modified="2013-07-24" version="1">MRIGFFTDSYFPEIDGVTYTIKLWRERLEAAGHEVYVVYPDGDYDPDDREIPVRSLPNPFYAGYRLPTFRRPSTLPDLDVVHCHGPASVGLLGRYYARKRDLPSIYTHHTPVEEYFHQATRSERLGDLLGKVYVPYENAFLGTFDVVTASTGRIDRDVEHVELPVGIDMDFFQPREGDWFDGEPVIGYSGRISNEKNVGELLRLADAMPDYRFVIVGEGPFRRRLEERAPDAVEFRDFLPREQLPGFLSSLSVFVTASTADTLGLSTLEANACGTPVAAADVPPFADTIGPENGRRFPYGDVDAMVDAVETCLDAEWDTRGAVERFAVSQTMAQLERIYREAAGAEPPATTPTAADSPTASGVAEPGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Y2</accession>
    <name>R4W4Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07275"/>
    <dbReference type="EnsemblBacteria" id="AGN01402">
        <property type="protein sequence ID" value="AGN01402"/>
        <property type="gene ID" value="L593_07275"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1485"/>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015660_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="709" mass="75121" checksum="3015E4F62FCAC885" modified="2013-07-24" version="1">MQRRAESLDRRLLALCLLTMALVGGLAVGTTAGAPVAGIAGGPDAGPPTPVRPASDAATASSLDAGGALSTSEVGESTSIANASAAQSSDPIVERVEYDLLPAQPDTVEARITYEIPDEVGSLTFSIAQGQYDVVGTDGFTRNDGTFEWDESGGGGTVTIRHPVTESFRAEGPDQRFVGGTGEWAIVTRPQTSTQWNYRFENPGLEYRLTTAGEGYAGKRFAFLGPHSTRSRTVGGEVLTLVVPDAADPASAPTEILDSVAYASDRLRFGNRNQEVVLIAAPTGEFDWGPPGLAIGADTRVAADQPVDAAVNVWVHEYVHTRQYRDADTVDGDAVADDAHWLVEGSADYYAALLSLEEGRIDYATFRNVLERGTMRPATDAVLTDRSTWADTDAEYEKGALVVGAIDRELRVASNGSETFQSIMSDWNSAETFRADDLEAAAERLGDESVREFVSAYTRTDATPSTWDRTTHSRLFGSDLPRFDYRVVSEPALSVIGPYRDGELPETTVVGEAVAAEVEVANVGNVSGQYRSTLFVGGSERAVSSGSLEPGETTTVSLSHRFGTAGDVRIVVGDVSRTVRVREPADPVVTSLRVSPRSPSTGDAVDVRMSVSNPTSRPADGNVTVFADGEPVGTERVQLTPGANRTVEISTGFDRAGRHNVSAGSLTIQLDVQEGSVLESIDEIPPVALATGLIALLAGATLLLFARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W555</accession>
    <name>R4W555_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_07910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446421.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07910"/>
    <dbReference type="EnsemblBacteria" id="AGN01527">
        <property type="protein sequence ID" value="AGN01527"/>
        <property type="gene ID" value="L593_07910"/>
    </dbReference>
    <dbReference type="GeneID" id="16182241"/>
    <dbReference type="KEGG" id="sali:L593_07910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1620"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OrthoDB" id="43727at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="153"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33410" checksum="35F85424A21BC1AC" modified="2013-07-24" version="1">MTTEPRHYLDVDDLTADELDEVLGLAAEYKAEQTEGVLHDDLDNQTLGMVFEKPSTRTRVSFETGMTQLGGHAIFLGDSDIQLGHGEPLKDTSRALSRYVDVLMGRMFDHESLEEIAAYSDVPVVNGLTDDAHPCQTLADLLTIQEHARGLEGTSVAWVGDGNNVAQSFVIGAALAGIDLTVATPEGYGIDDEVVERAAELGGEPAIVDDPADAVADADVIYTDVWVSMGQEDEREEKLANFDGFQVNDELLDSAADDVSVMHCLPAHRGEEITDDVLESDHAIVWDQAENRLHAQKGLLVWLCEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5B2</accession>
    <name>R4W5B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446516.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08385"/>
    <dbReference type="EnsemblBacteria" id="AGN01622">
        <property type="protein sequence ID" value="AGN01622"/>
        <property type="gene ID" value="L593_08385"/>
    </dbReference>
    <dbReference type="GeneID" id="16182387"/>
    <dbReference type="KEGG" id="sali:L593_08385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1718"/>
    <dbReference type="eggNOG" id="arCOG02453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412400_0_0_2"/>
    <dbReference type="OrthoDB" id="77157at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="21688" checksum="C736383AC37C6BCC" modified="2013-07-24" version="1">MDYELAVDGGPDSIPGGTSVLLVHPSTAETDRVDTDFLKKDTDHFLVISTRTTAREVTQKLDYYDVDEDRAVILDTLSVERGYSRRTRDDVHYVSSPDDTDGIVEQTKQFLESHDGKIRLSFDSVTELAYYAGEEEARDAVERILDLLVDHDAVGLFHLSTEVHDEDVLEGYRDRFDVVIDLAEDDSIDVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T1</accession>
    <name>R4W5T1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446816.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09885"/>
    <dbReference type="EnsemblBacteria" id="AGN01922">
        <property type="protein sequence ID" value="AGN01922"/>
        <property type="gene ID" value="L593_09885"/>
    </dbReference>
    <dbReference type="GeneID" id="16182847"/>
    <dbReference type="KEGG" id="sali:L593_09885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2035"/>
    <dbReference type="eggNOG" id="arCOG00264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047202_0_0_2"/>
    <dbReference type="OrthoDB" id="30451at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="221"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="367" mass="41139" checksum="A0FE27ACAB2C81BA" modified="2013-07-24" version="1">MDRTRLDPLLSPLRRAWEAVQPPPRLVDWTLFAIVVFETVSGLYSFTVADHSGWWLFWAHRIAGLTFAVFLAFKLARVRDRLTDPDRWLRSMALSVLTAIAAIGALATGIVWVGGSDVRISYWTLLSIHVAFGLLLVPLLIAHLTSRFRLPRPQDLDRRRTTLQYSALFVGGAVAYRGQEFANRLLGTPGEDRRFTGSQVRKGEGNDAFPLTSWVADDPDPIDRDSWTLDVRGAVDSELTLEYSDVDSDAEIEALLDCTSGWYTVQDWRGIRVGDLLEEVGPASGAEYVRFVSVTGYRWSLPIEEARDALLATHVGGERLSHGHGAPIRLVAPGRRGFQWVKWVVRVDVRKRSDPAQWLVTLISGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T3</accession>
    <name>R4W5T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGM99982">
        <property type="protein sequence ID" value="AGM99982"/>
        <property type="gene ID" value="L593_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00140"/>
    <dbReference type="eggNOG" id="arCOG09322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2930353_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="6143" checksum="A29450A56720D70A" modified="2013-07-24" version="1">MASLVSQIEELVELFTDVATSDPVSPLLVVAGAAIFAVAVGIVSVLVVGAILETMGRPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U0</accession>
    <name>R4W5U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LOR/SDH bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446831.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09960"/>
    <dbReference type="EnsemblBacteria" id="AGN01937">
        <property type="protein sequence ID" value="AGN01937"/>
        <property type="gene ID" value="L593_09960"/>
    </dbReference>
    <dbReference type="GeneID" id="16182589"/>
    <dbReference type="KEGG" id="sali:L593_09960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2052"/>
    <dbReference type="eggNOG" id="arCOG04422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056125_0_0_2"/>
    <dbReference type="OrthoDB" id="22696at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005239">
        <property type="entry name" value="CHP00300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00300">
        <property type="entry name" value="TIGR00300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharop_dh_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="429" mass="45516" checksum="0FBEAC19DB4476BA" modified="2013-07-24" version="1">MPSRTVELEGHIIDSGTMERCFTLVMDLGGHFEVEAFDIGRHEDEESYCRMEVEADTESDLREILHELNKNGAYLSDPSDVTVEPAPADGVVPPEFYSTTNHPTEIRWEGAWIDVEYPEMDCAVVVEDGESSDGPRAETRVLNGVEEGDLVVVGDAGIRVDPPERPRGSGGAFGFMQGGVSSERPSESLIGEVADALEEVQEQGGDVLAVCGPAVIHSGGADDLAALVREGYVDALSAGNGFAVHDVERDIYGTSLGMDVETMEHPREGHKHHIYAISEISRRGGLEPAVEAGVVESGVMYQCIDKDVDYVLAGSIRDDGPLPDTITDAIEAQNAIREQAREADLVLMLSTLLHSVAVGNCLPSTTKVVCVDINPATVTQLLDRGSAQAIGLVTDVGAFLPMLADAVLGEAAPKDGCGNDRGCGGSGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W644</accession>
    <name>R4W644_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00990"/>
    <dbReference type="EnsemblBacteria" id="AGN00153">
        <property type="protein sequence ID" value="AGN00153"/>
        <property type="gene ID" value="L593_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.203"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="2"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22205" checksum="DE91EB676A9562DD" modified="2013-07-24" version="1">MGPSGSGKSTLMNMLGCLDTPDEGTVEIDGRSVGDLSGAQRAKLRGTKIGFVFQTFNLMPRLSAAENVTLPMVFNDVVDEGRRSRAKTLLDRVGLGDRLDHAPNELSGGQRQRVAIARALANEPTLILADEPTGNLDSETGADIMELFEELHASGRTILMVTHERHIAERAERIVHLLDGELDYVEDVSDVVPTGPATDGAGNGGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F0</accession>
    <name>R4W6F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445237.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01960"/>
    <dbReference type="EnsemblBacteria" id="AGN00343">
        <property type="protein sequence ID" value="AGN00343"/>
        <property type="gene ID" value="L593_01960"/>
    </dbReference>
    <dbReference type="GeneID" id="16182488"/>
    <dbReference type="KEGG" id="sali:L593_01960"/>
    <dbReference type="eggNOG" id="arCOG10183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465170_0_0_2"/>
    <dbReference type="OrthoDB" id="91126at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="184" mass="20976" checksum="DEE640693C7FFD61" modified="2013-07-24" version="1">MYRLQHRLRHAAGGVADAILPGRCYGVFTLKPNEFVGYLDVSLSEVKALLEARSYSYSPISAKKLHPDHPVSDDGSYRRLDPADRSKQWHVHLFERSEGIEVFSHYELRPEPWDPIDIRRPVDHYWPEWGETCLLGQHCPGLKSLLETYGRYEGDRSALGTAPLQRRPSPEEPAPTAEETPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H9</accession>
    <name>R4W6H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447226.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11945"/>
    <dbReference type="EnsemblBacteria" id="AGN02332">
        <property type="protein sequence ID" value="AGN02332"/>
        <property type="gene ID" value="L593_11945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180714"/>
    <dbReference type="KEGG" id="sali:L593_11945"/>
    <dbReference type="eggNOG" id="arCOG06294">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098906_0_0_2"/>
    <dbReference type="OrthoDB" id="103447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="19919" checksum="0D4F742A7B03878A" modified="2013-07-24" version="1">MTAHGGQLLQSKVVSDLGDVLERALDGSITGYATVEPQDVLLLDAEGVGVLAFEAGVPVAARHSGTGRVGREALAELSVPGPCRVELYERHRPVPFVEEPANRIPPGLPADRLVRDADLANRTRSAAADRGIGERTDADALQAFLTDEERVDAIRREAREEARARAEQWGLEDALVDSSPDGDSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I3</accession>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02285"/>
    <dbReference type="EnsemblBacteria" id="AGN00408">
        <property type="protein sequence ID" value="AGN00408"/>
        <property type="gene ID" value="L593_02285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182481"/>
    <dbReference type="KEGG" id="sali:L593_02285"/>
    <dbReference type="eggNOG" id="arCOG06416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130241_0_0_2"/>
    <dbReference type="OrthoDB" id="106433at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="19124" checksum="DF0DBBEBFF682489" modified="2013-07-24" version="1">MTRFDASTPDDRRALVADAIRAHRERGSVFCTLEAGSPPPDHATTDDAAIDGDDAVQDADSVVSDAERPAPDVPEADSGDGTLDGEPDAPAWIQFSDPESQLNLDCTDEEYDRITDVLSTAGAFTIDEQASPEEAEGRNLRVTAYADPDRIGQVVDRIFVEGFGYDEDYRLWATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I5</accession>
    <name>R4W6I5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_12020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12020"/>
    <dbReference type="EnsemblBacteria" id="AGN02347">
        <property type="protein sequence ID" value="AGN02347"/>
        <property type="gene ID" value="L593_12020"/>
    </dbReference>
    <dbReference type="GeneID" id="16181075"/>
    <dbReference type="KEGG" id="sali:L593_12020"/>
    <dbReference type="eggNOG" id="arCOG00535">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_9_3_2"/>
    <dbReference type="OrthoDB" id="127668at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="6829" checksum="BEFA04717BAF1BEF" modified="2013-07-24" version="1">MNVVVEVAGEDAREVTLPADATYDDLLEAVDRSKHEATALVDGQPVPADAPVDADAVTVLQLVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J9</accession>
    <name>R4W6J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12145"/>
    <dbReference type="EnsemblBacteria" id="AGN02372">
        <property type="protein sequence ID" value="AGN02372"/>
        <property type="gene ID" value="L593_12145"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="191" mass="20160" checksum="C5BD839BE37718E7" modified="2013-07-24" version="1">MRTATRRVAGIVVTEFERSIRSYALLVLSVLFVCFAGGLAAIQWVPIMFRDSHVPTSTLAMLNRMRQPTVLLVPAIGIALGYGAIVGAVERGSIKLVLGLPVGRGSVVLGTVLGRTAVVSTAILVGYGVVGLIALGFYATFDAAAFLAYTLLTICYGTTYVSIAVGFSAFARSRSRALFGAIVLYAIFLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K2</accession>
    <name>R4W6K2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_02460</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445337.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02460"/>
    <dbReference type="EnsemblBacteria" id="AGN00443">
        <property type="protein sequence ID" value="AGN00443"/>
        <property type="gene ID" value="L593_02460"/>
    </dbReference>
    <dbReference type="GeneID" id="16182593"/>
    <dbReference type="KEGG" id="sali:L593_02460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.499"/>
    <dbReference type="eggNOG" id="arCOG04468">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="35022" checksum="5FA8FA95B6C54351" modified="2013-07-24" version="1">MASHTVLVTGGTGFLGSYVAEDLVESNQDVVAFDLSTDDWILSKLGVAEDVEIRQGDVTDPTEVVRAVRETGATRIVHLAALLTNAARDDPRAAAEVNVLGTNNVFEAARTLDDQVERVAWASSAAIYAPPDRYDLPVDEEDLVYPDTLYGATKGYNEHQARVYAEEYDLSLVGLRPTVAYGPYRETGGSAFLADIVEKPALGESFRVEYGDQAIDWQHARDIAQAFRKAALIPDAELSQRVYNVAGELATIREAVETMREIIPDADLTVSDEGELPWTQDLDDGDAKRDLGYRVEYGLERGFRQYANALRADAGMELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W773</accession>
    <name>R4W773_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
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            <dbReference type="EMBL" id="AGN00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="434" mass="46293" checksum="AD229D94FC5CC227" modified="2013-07-24" version="1">MAQQIVDQLAVEEYTLGLVGPDQEWAGTVADGGTVRTHTPPACWGPMITPKFRGGHEVTKPIAVEGAEVGDAIAIRIRDIEVTSVATSTGSMAEREGAFGDDPFVDHQCPECGAKWPESVVEGTGEESIRCAECGANASSFAFEYGITTVFDDDREVGITVDHDAAHDLAERAEEAAALPEHSRQHPILLYEPSEMPGTLGHLRPFIGNIGTTPPVELPDSHNAGDFGQFLIGAGHDWGLEDEEELAARTDGHMDVNAVREGAILVCPVKVDGGGIYVGDMHANQGDGELALHTTDVSGHAEFEVEVIDGLDLDGPLLLPNVEDLPHIAEPYSDEDVERGRELGEEYGVDVETDVGPIQVIGSGATVNDATQNAFDRAGDLLDMSEGEVRTRCTFTGGVEIGRLPGLVQLTMLAPMDVLEEQGMAHLVREQYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W797</accession>
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        </submittedName>
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        <name evidence="3" type="ORF">L593_14090</name>
    </gene>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <begin position="55"/>
            <end position="71"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="403D53479B5FC5FB" modified="2013-07-24" version="1">MLEQSQTEARERAQQAAQETATEARTQLGRRAFDALEEYFPEEAEQRQQNNRGQLLAVGFAIGFVLGILVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J2</accession>
    <name>R4W7J2_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Major facilitator superfamily protein</fullName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02942.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02942">
        <property type="protein sequence ID" value="AGN02942"/>
        <property type="gene ID" value="L593_15040"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="261"/>
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        </location>
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        </location>
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        </location>
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            <begin position="24"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="46486" checksum="B74A437ADD0F40D0" modified="2013-07-24" version="1">MASDTAEAAGPIDAFRSFFALERDVLVLSLAMFAFSLGFQMTSRFLPEYLVALGASGFVVGLFGTVGNVISAVYPYPGGALSDRIGSRYSLTLFGLLSTFGFAVWLIAPGLEPITIDGVAIEPWLWIFVGLLLAQAWKSFGLGATFAVVKQATDPERLAAGFASTETFRRTAFLIGPVLAAVLIGLDDTFTVSFQYVLAVAVAFGAIGTIAQHVLYDASEDTIGDSFEGIQQIREDLANMPAPLRPLLVGDTLVRFANGMVYVFFVLVVTDFLAVGVDAISIGGATLNVDLSPAAFFGYLLGVEMLVALLVMAPAAKLAECVGLKPVVATGFAVYAIFPIVLIFAPANPEALVAVFAFSGLRFAGLPSHKALIVGPAQADAGGRVTGAYYLLRNTIVIPSAAIGGALWDFVSPEVAFTVAAVIGLLGTGYFLVFGEEFEAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K2</accession>
    <name>R4W7K2_9EURY</name>
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        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
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        <name evidence="2" type="ORF">L593_05295</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HalOD1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9511" checksum="A5695DDFB946BC8A" modified="2013-07-24" version="1">MSLQAADGTPIATTTVEQTDSASVVISQIVTDVADETIDDLPTLANSVDPDALDAVFASEGAIGRLTFVFAGYDILLDSSGAVEVHQSGTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7N5</accession>
    <name>R4W7N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05620"/>
    <dbReference type="EnsemblBacteria" id="AGN01073">
        <property type="protein sequence ID" value="AGN01073"/>
        <property type="gene ID" value="L593_05620"/>
    </dbReference>
    <dbReference type="GeneID" id="16182443"/>
    <dbReference type="KEGG" id="sali:L593_05620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1149"/>
    <dbReference type="eggNOG" id="arCOG04558">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_10_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="4">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="35742" checksum="3428D525C8A4B87B" modified="2013-07-24" version="1">MTTDDRLRRDDADGRAPTGTVEEPIPVVLATDIGSDVDDTWALAQLLRTPELDLQLVLTETGEARYRGEVAAKLLERADRTDVPIGLGVEDGAMAADDRHQGPWVDDYDLESYPGTVHEDGVGAFVDLVAATESPVTVISIAPTPSVAAALDRDPELAESCRFVGMHGSFYIGYDGTPERDAETNVRVDPAAFRRVLAADWRDVLLTPLDTCGLLTLDGERYNAIWSATDDPLLRSVIENVCIFAPRVPWMPYEDFTRRSSTLFDSVAVDLARTESFVEVERARFDVTDDGLTVPGEGGEFEARVALEWADLDGFEAYLTETLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7P4</accession>
    <name>R4W7P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445987.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05720"/>
    <dbReference type="EnsemblBacteria" id="AGN01093">
        <property type="protein sequence ID" value="AGN01093"/>
        <property type="gene ID" value="L593_05720"/>
    </dbReference>
    <dbReference type="GeneID" id="16181473"/>
    <dbReference type="KEGG" id="sali:L593_05720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1171"/>
    <dbReference type="eggNOG" id="arCOG04425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_2"/>
    <dbReference type="OrthoDB" id="108917at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="2">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17188" checksum="98E93FC8B34CFB2E" modified="2013-07-24" version="1">MTPDTDADDPIRIAFVCVQNAGRSQMSTAFAEHERERRGLEDAVEILTGGTHPADRVHDEVVDAMADAGFDVADRTPREITSEELRSCDHVATMGCSTLDVGKVDDTVNVRDWALEDPDGKDPERVREIRDEVEERVSEMFDEISRDSGPNREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q2</accession>
    <name>R4W7Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444853.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00020"/>
    <dbReference type="EnsemblBacteria" id="AGM99958">
        <property type="protein sequence ID" value="AGM99958"/>
        <property type="gene ID" value="L593_00020"/>
    </dbReference>
    <dbReference type="GeneID" id="16181367"/>
    <dbReference type="KEGG" id="sali:L593_00020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.4"/>
    <dbReference type="eggNOG" id="arCOG02246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096061_0_0_2"/>
    <dbReference type="OrthoDB" id="42414at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGM99958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="32227" checksum="98B1BD2CFADAD837" modified="2013-07-24" version="1">MQALVIVAHGSHLNPGSSEPTFEHADTIRATGAFDEVREAFWKEEPHFREALRTVAADEVYVVPLFISEGYFTEEVIPRELRLEGWDVEDWESGDGVSASHATYAAADVEKDVHYVGPAGTHDAMSDVIVRRAESVTGDPDVGDGFGLAVVGHGTKRNEHSARAIEYHADRIDEMGRFDEVQALFMDEEPEVDDVTDYFESDDVVVVPLFVADGYHTQEDIPEDMGLTEDYRDGWETPATVDGQRIWYAGAVGTEPLMADVLLERAADAGADVGDAVEQVREQTRVSPSPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S1</accession>
    <name>R4W7S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444903.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00009">
        <property type="protein sequence ID" value="AGN00009"/>
        <property type="gene ID" value="L593_00270"/>
    </dbReference>
    <dbReference type="GeneID" id="16181272"/>
    <dbReference type="KEGG" id="sali:L593_00270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.54"/>
    <dbReference type="eggNOG" id="arCOG03067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_5_0_2"/>
    <dbReference type="OrthoDB" id="105261at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13050" checksum="6F53BE0536677F80" modified="2013-07-24" version="1">MAELPADDDPDAIEPLLAALGGKYAARILAAADRPRSARELSDELDVPIATCYRRIEELEAANLLTCHGRESSNRGRRTRVYRRTISEVTLGLEGDVPVLDVDDRDSIAGSSRTGSLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y7</accession>
    <name>R4W7Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446217.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06880"/>
    <dbReference type="EnsemblBacteria" id="AGN01323">
        <property type="protein sequence ID" value="AGN01323"/>
        <property type="gene ID" value="L593_06880"/>
    </dbReference>
    <dbReference type="GeneID" id="16181911"/>
    <dbReference type="KEGG" id="sali:L593_06880"/>
    <dbReference type="eggNOG" id="arCOG03933">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104483_0_0_2"/>
    <dbReference type="OrthoDB" id="89714at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="24010" checksum="6DA0E74CF091A9E8" modified="2013-07-24" version="1">MSTLIALVAAITVVTITLGGTMVIVEDAFRETQRGDAERAVAIQASDRLVAADGPIADAPNVVNESELANLSTADLRRVGATNRFAMAVALDGERIAALGDPDGGHVVRRIVLVQSSERAVRTPTIVGGEDPELTVPVRTDAVEVTISPPPGTTVTEVRSGGRVVLADPGGLSGTFDVETSPYRTLAFAFDTTGPLATGDVEIAYRSTDRDRAILAVTVDDRDTAGGGGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z6</accession>
    <name>R4W7Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chloromuconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_01180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01180"/>
    <dbReference type="EnsemblBacteria" id="AGN00189">
        <property type="protein sequence ID" value="AGN00189"/>
        <property type="gene ID" value="L593_01180"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.240"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="36755" checksum="03A7A7FF5282875F" modified="2013-07-24" version="1">MTGTPQSVEPSFERIELPLAVPFEISRGSMTTTEVVVVRLDDGERVGIGAASPSAYYGEDPDSVASALPDLLDVVESVGDPLAIQRIELDLRATAPADAAARAAVSIAVHDLAAKRLGVPLYRLWGLDPDAAPSTSFSIGIADPETMAARAAEAVERGFGTLKLKLGTDDDRSRLLGVREAVPEATLRVDGNCAWDRETALDRLDLLETAEVGLLEQPVAADDLDGLRAVTDATSIPVVADESCVVASDVPAVAATCDAIVCKLMKCGGPWAAREQIEAAHAHGLEVMLGCMVESNASIAAGWHLAPLVERVDLDGSLLLAEDPFDGVTLADARPLLREQEGFGTGAGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W803</accession>
    <name>R4W803_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Threonine synthase</fullName>
            <ecNumber evidence="5 9">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_07180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446277.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07180"/>
    <dbReference type="EnsemblBacteria" id="AGN01383">
        <property type="protein sequence ID" value="AGN01383"/>
        <property type="gene ID" value="L593_07180"/>
    </dbReference>
    <dbReference type="GeneID" id="16182032"/>
    <dbReference type="KEGG" id="sali:L593_07180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1466"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_2"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="80"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="419" mass="43879" checksum="9A668EE321988F0B" modified="2013-07-24" version="1">MSLSLTEPASATPDVADDGVWLACIECGETLAPFDDVVYTCPDCDGLLEARYAEPPTFDDFSGSGVWRYEDALPVPKHVSIEEGNTPLYTVPRLEESVGVDSLQIKHEGMNGTGSFKDRGMTVGVGAAKELGVGRLACASTGNTSAALAAYGARGGMETLVLLPAGKVAAGKVAQASLHGARILEVDGNFDVCLDIVQDLAERGEAYLLNSLNPFRLEGQKTIGLEILETHHERLGEYPDRIVLPVGNAGNTAALYKCFRELVQAGELDPEQVPKLTGVQASGAAPMVEAIENGWDHVERWDEVETIATAIRIGNPVNAPKALPGIRETGGTAVAVDDEAITAAQRDLAEEGVGVEPASAASLAGLRELRDRGVVGDDEQVVCLTTGHLLKDPDAAAAAGADPEPVPGNTEGVLEHLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W811</accession>
    <name>R4W811_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445098.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01255"/>
    <dbReference type="EnsemblBacteria" id="AGN00204">
        <property type="protein sequence ID" value="AGN00204"/>
        <property type="gene ID" value="L593_01255"/>
    </dbReference>
    <dbReference type="GeneID" id="16182670"/>
    <dbReference type="KEGG" id="sali:L593_01255"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003326_0_0_2"/>
    <dbReference type="OrthoDB" id="93507at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="30064" checksum="6FC5BB1967ED7207" modified="2013-07-24" version="1">MPRCPECGSDVARTDAFCTQCGASLDDVDVGAVEEEASVPNDEDDGRLAFDGDPFDADVFEFSFKYPLANGLGTIALATVLLLLSILIIPYFVFIGYSVRVGRAAAIGRAAPPELGDWWGLLADGFRLFVAVAVLMVPAGAVYAALLLADQVVLANLVYFPMLVAVAAITPVFYGRGSVREVYSDLRFLRFLTTSNFWIGVAYYLGISFVLYVAAFVLSIVFVITLIGIPVAFAIWLVFPAYFTLLQAALWGRIYHDAAEEGVVDPVGRVDQLDTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W845</accession>
    <name>R4W845_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446377.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07690"/>
    <dbReference type="EnsemblBacteria" id="AGN01483">
        <property type="protein sequence ID" value="AGN01483"/>
        <property type="gene ID" value="L593_07690"/>
    </dbReference>
    <dbReference type="GeneID" id="16182168"/>
    <dbReference type="KEGG" id="sali:L593_07690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1576"/>
    <dbReference type="eggNOG" id="arCOG00831">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_1_2"/>
    <dbReference type="OrthoDB" id="95543at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="28009" checksum="F7983C893FC07426" modified="2013-07-24" version="1">MTLRRPLEFDHDDRKSIYEYVEEHGAVDPDVAQTDCLPHDAGGFRHHVAILRRNGYLARTDDGHLEVAVDSDETEEEYDREDLSFRVRPARQADLTGIVGAMRQVVEDGRYIVAESVAQEVDHDQALLRHNEIESRMFFVATVDDEVVGWVHLRSPELEKLAHTAELTLGVLEEYRGNGIGSHLLQRGLQWAASRGYEKVYQSLPATNEEAIAFLEEHGWAIEAVREDHYVIDGEYVDETMLAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D9</accession>
    <name>R4W8D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03065"/>
    <dbReference type="EnsemblBacteria" id="AGN00564">
        <property type="protein sequence ID" value="AGN00564"/>
        <property type="gene ID" value="L593_03065"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03065"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6306" checksum="FDD52817C59A4FC8" modified="2013-07-24" version="1">MDLIGAIRGLDSGAVVRLLSDNEQSLTDVPEWAEESGNEVLEVEETEDHYAIYVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F0</accession>
    <name>R4W8F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Psp operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446597.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08790"/>
    <dbReference type="EnsemblBacteria" id="AGN01703">
        <property type="protein sequence ID" value="AGN01703"/>
        <property type="gene ID" value="L593_08790"/>
    </dbReference>
    <dbReference type="GeneID" id="16182071"/>
    <dbReference type="KEGG" id="sali:L593_08790"/>
    <dbReference type="eggNOG" id="arCOG06419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184943_2_0_2"/>
    <dbReference type="OrthoDB" id="131595at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6553" checksum="58BA5100E3E98BC6" modified="2013-07-24" version="1">MDPARKSALLWAIVGALSFGVLYQGYVIAGAAFDGRVLAGGMVVVGVVTAVLAPVVEQRLHASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F4</accession>
    <name>R4W8F4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">L593_08840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446607.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08840"/>
    <dbReference type="EnsemblBacteria" id="AGN01713">
        <property type="protein sequence ID" value="AGN01713"/>
        <property type="gene ID" value="L593_08840"/>
    </dbReference>
    <dbReference type="GeneID" id="16182556"/>
    <dbReference type="KEGG" id="sali:L593_08840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1811"/>
    <dbReference type="eggNOG" id="arCOG02012">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_2"/>
    <dbReference type="OrthoDB" id="77838at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="33896" checksum="92B4CAE4D6D0DBF4" modified="2013-07-24" version="1">MEAYIERAADGDDLTQAEAREAATAVFEDATEAQIGALLTALRAKGETEQEIAGFAEGMRAAAKTIDPDREPLVDTCGTGGDDYDTINVSTTTTFVVSGAGVPVAKHGNYSVSSSSGSSDVLEAAGVTLESDPDAVEDLIEAEDVGYMHAPAFHPAMKAVIGPRKELGMRTIFNVLGPLTNPAGANAQIVGVYDPDLVPTLANALANLDVDRALVVHGSGLDEIGIHDETVAAEVSGGDVSEFEIAPEEIGLDRAPVSEIAGGSPEVNAKDLEGILTGEVTGPKRDVILANAGAAIYVAGEANSIEEGVEVAANAIDSGEAAARLDALREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F9</accession>
    <name>R4W8F9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="5">HAT</shortName>
            <ecNumber evidence="5">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Homoserine transacetylase</fullName>
            <shortName evidence="5">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metXA</name>
        <name evidence="9" type="ORF">L593_03365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445518.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03365"/>
    <dbReference type="EnsemblBacteria" id="AGN00624">
        <property type="protein sequence ID" value="AGN00624"/>
        <property type="gene ID" value="L593_03365"/>
    </dbReference>
    <dbReference type="GeneID" id="16180514"/>
    <dbReference type="KEGG" id="sali:L593_03365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.681"/>
    <dbReference type="eggNOG" id="arCOG00627">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_2_2"/>
    <dbReference type="OrthoDB" id="8770at2157"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="44812" checksum="E23A28346E622E96" modified="2013-07-24" version="1">MSTTVATEDLGEFQFECGESIPNLEVAYETYGEFTGDNAVLVCHALTGSAHVAKRQFDGDEDDALADVPETEGQAQSWWSDVVGPGKAIDTNEYYVVCVNDPGSCYGTTGPASENPETGEPYGTDFPPVTVGDWTRVQREVLDSLGVGRLHAVVGGSVGGMNVLDWVSRYPDDVRRAVPIAAAPRLDAQSLAIEAIAQRAITSDCNWNEGHYYGEDQPDPTHGLQIARQLGHVLYLSKASMEERFGRRAAGREAERDTFPSDPAADFFPYRDVESYLDYNARKFAERFDANSYLYLTRAMDNFDLASGYEDDADALAAFTGEALVMSFTADWHFTVAQAAELADAFRETDARVAHHVAESDHGHDAFLVEPETVGPPLADFLEAGVEGKAVTDADGDVPEQDTIPPVHSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G3</accession>
    <name>R4W8G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methylase, NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_08990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446637.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08990"/>
    <dbReference type="EnsemblBacteria" id="AGN01743">
        <property type="protein sequence ID" value="AGN01743"/>
        <property type="gene ID" value="L593_08990"/>
    </dbReference>
    <dbReference type="GeneID" id="16180293"/>
    <dbReference type="KEGG" id="sali:L593_08990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1844"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="107"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="303" mass="33079" checksum="4D70CA5F7285069C" modified="2013-07-24" version="1">MHEVLERYEPIVDEFDAFAAAIERPLGKTVRVNTIKADVDRVREAFDEAGIDAEPTDWNPELLAVDTDGPGATWPAFHGWIHTQEAVSTLPPIALDPDPSDTVWDACAAPGSKTTQLAATMDDRGRIVANDRNMGRLSALRFNAERLGVTNAVVTNRDARNYSLDPLEVDAFDAALVDAPCSGEGTLRKNPAALETWSEGFLTDVSGVQTDILRRAIQATRPGGRVVYSTCTYAPEENEAVLDAVLEQEACRIVEQELPLESRPGVTEWQGDSFDPSVERAARVYPHLNDTGGFFLATLEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J5</accession>
    <name>R4W8J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446737.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09490"/>
    <dbReference type="EnsemblBacteria" id="AGN01843">
        <property type="protein sequence ID" value="AGN01843"/>
        <property type="gene ID" value="L593_09490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182564"/>
    <dbReference type="KEGG" id="sali:L593_09490"/>
    <dbReference type="eggNOG" id="arCOG09132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898989_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="32925" checksum="67D21D613AAC0C0E" modified="2013-07-24" version="1">MQRRRFLAGTGATGLAALVGCSGILGDGSAAGSDAEPFARWAPARDPNPDRTYNYEIGALQPSAVLAASDEITPADLSPGVPHESVAWDALAASDVERVIDLSAGGAASPRTVAIFDGDVDPATIVSALDERPNYDREHLGDYRGYEIHGTGAGFFFHAVRDGRVLEVDRYAYSEADRELVESVIDLGEGDGDRLLDSHDGFATAATRLDATHWTSVRLEDPDRETDVEQGRFRGVVATGASATVADGGSTVRALLAFRDVDARRSAPIEPYVDQIRAEDTVESVDFASEGRILDVTLRLDYPAPFVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T6</accession>
    <name>R4W8T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445808.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04825"/>
    <dbReference type="EnsemblBacteria" id="AGN00914">
        <property type="protein sequence ID" value="AGN00914"/>
        <property type="gene ID" value="L593_04825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181107"/>
    <dbReference type="KEGG" id="sali:L593_04825"/>
    <dbReference type="eggNOG" id="arCOG00664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="25980" checksum="0130DB51BA5A80CE" modified="2013-07-24" version="1">MAADETREWTAIVPAAGEGTRLRPLTAERPKPLVAVAGKPLLAHVFDALAPIDPASFVVVVGYRGEQVRAHFSDSYGGVPIEYVHQPEPRGLADAVGRAAPVVDGPALVCNGDNVFATDLEPLAAAHEAADGDPVATMLVEEASVETARETGVVVTDEAGRVERVVEKPDSPPSTLVSAGAIAVEPSIFEAIDAIEPANTGEYELADSLTWLLDRGETVHTHRYVGERVNVNAPADVELAEAVLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y3</accession>
    <name>R4W8Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05450"/>
    <dbReference type="EnsemblBacteria" id="AGN01039">
        <property type="protein sequence ID" value="AGN01039"/>
        <property type="gene ID" value="L593_05450"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1112"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="206" mass="21693" checksum="F8960B4E7276E474" modified="2013-07-24" version="1">MDVPALDRSHGYLVDSGRRLTDEMIGKLLGDDVESSGRYLAEVIYGANDGIVTTFAVVSGVAGAALNPSIVLILGAANLFADGFSMGMSNYLSRRSELDYERSVQGDEPGPPSAPSDAKSPRRTAFVTFLAFVVAGWAPLIPYILALEPSFPLSIAFTGLAFFAVGSSRSVVTRRRWYVNGAEMFVVGMAAAVVAYTVGNLLGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W904</accession>
    <name>R4W904_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8e</name>
        <name evidence="8" type="ORF">L593_05750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445993.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05750"/>
    <dbReference type="EnsemblBacteria" id="AGN01099">
        <property type="protein sequence ID" value="AGN01099"/>
        <property type="gene ID" value="L593_05750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181484"/>
    <dbReference type="KEGG" id="sali:L593_05750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1177"/>
    <dbReference type="eggNOG" id="arCOG04154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OrthoDB" id="116294at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_S8e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13358" checksum="EAE21954F5172BB3" modified="2013-07-24" version="1">MVEHGRSTRSRTGGRRRPKRKRRKHEIGNEPTETEVGEQKLKAVDARGNSEKVRALATDVASVADGDETVAATIEDVVENDANPNYVRRNIVTKGALIETDAGTARVVSRPGQDGQVNAVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W933</accession>
    <name>R4W933_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447212.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02318">
        <property type="protein sequence ID" value="AGN02318"/>
        <property type="gene ID" value="L593_11875"/>
    </dbReference>
    <dbReference type="GeneID" id="16181868"/>
    <dbReference type="KEGG" id="sali:L593_11875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2444"/>
    <dbReference type="HOGENOM" id="CLU_1782566_0_0_2"/>
    <dbReference type="OrthoDB" id="143218at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15176" checksum="A8F9088DD09BE9BF" modified="2013-07-24" version="1">MWKLPCWPHGSTPSESAASLAGCSSLPIVGGDGGSGGLSYGDTVEDEIVADGPRDPIYNDLATPHEFSGSSGDRIRATQDSQAFDCWLLVVDGNDNLVVENDDRSMSTLNSGFETTLPADGTYTLWPGSLSGQATGGYTLSLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W946</accession>
    <name>R4W946_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12075"/>
    <dbReference type="EnsemblBacteria" id="AGN02358">
        <property type="protein sequence ID" value="AGN02358"/>
        <property type="gene ID" value="L593_12075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2484"/>
    <dbReference type="eggNOG" id="arCOG02848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123159_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="205" mass="22641" checksum="33BF720A23E86AF5" modified="2013-07-24" version="1">MHSVVLGWLAGLFAVMAAMLALTAAVVGWPILLLAIPLAAVAYLFWYHATGRLTERLRQRARRQGGRRRSAGTRRDRRRRRAAATGFGPQNDPDGSGGTYWREERRRARERTAAERGRDRAEPWAPGPGHRGSEASGRRPGAQPSNAGMSPDRARGVLGVRSDADAETIRDAYREKVKETHPDRGGSTDAFKRVNEAYETLDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W987</accession>
    <name>R4W987_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="11">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rtcB</name>
        <name evidence="14" type="ORF">L593_06610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446163.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06610"/>
    <dbReference type="EnsemblBacteria" id="AGN01269">
        <property type="protein sequence ID" value="AGN01269"/>
        <property type="gene ID" value="L593_06610"/>
    </dbReference>
    <dbReference type="GeneID" id="16181820"/>
    <dbReference type="KEGG" id="sali:L593_06610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1349"/>
    <dbReference type="eggNOG" id="arCOG03158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012374_0_0_2"/>
    <dbReference type="OrthoDB" id="22545at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="13">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="899"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="683"/>
            <end position="687"/>
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            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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        <location>
            <begin position="809"/>
            <end position="810"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
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        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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        <location>
            <begin position="873"/>
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        </location>
        <ligand>
            <name>GMP</name>
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        </ligand>
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        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
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        <location>
            <begin position="899"/>
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        <ligand>
            <name>GMP</name>
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        </ligand>
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        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="977" mass="108354" checksum="C09DF5DD5253C4B8" modified="2013-07-24" version="1">MTTFDADGITLEQVEEYVWEIPQSGDMRVPARVFASEALLEEISDDKTLQQLTNTTNLPGITSHAICMPDGHQGYGFPVGGVGAMDAEDGCISPGAVGYDINCLPGDTEVLLEYGRSVPIEELRDRFEEERAIVADGNLESADIRLFTERDGATVYEIETDTGDVIEATADHPISTHDGMVDVEDLAVGDEVRLQPFRGIEDKEPEAFTLLDESDFEDDNPQLVRALTDRDLLPLRSTDDAFHRLLKLVGFHTGDGAIGAGGQTWFYGDPEDLASIQDDIRAIGFTPSKIYERDRSHEVNGNQFEATEYSVRGSSKAFQQLLLKLGAPDGRKIESDFTTPEYFDRLATWQQALYASAYFGAEMNAPAAQHDKNLYCPKVSQTRVAEHADAAEQFLIDLASFLADLGIETNPIERFETDSSADRETERLRLGIKNDSQNLIQFFSTVGYRYNRSKRRKSIKALQYCKRKEREIERRVDIADQARAMADGGTPVPEIKTEFEINDRFIERSVWSGRDGRPRPPLDFPDFDDYCDALSVGDDLSVDATIESIEPAGERTVYDIGVDHPAHNFVANGFVVSNCGVRMMTTDLTYEDIQGNEQELVESLFANVPCGLGGGGIVETDVDTIDEILDRGVEWAVENGFGVEDDLLHCEDEGRRPDADPSAITQKAKNRGKNQVGSLGSGNHFLEVQRVTDVYREDVADSFDLEENQIVVLIHCGSRGLGHQTCNDYLRKIEQTHEGLLDQLPDRELAAAPAGSQLAEEYYGAMCAAINFAWVNRQLIMHRVRQVFEKTFDRSWEDMEMELLYDVAHNIAKKEVHEVGLDEHGAAVPRDRAESTEERELYVHRKGATRAFPAGREEVPAAYRDVGQPIIIPGSMGAGSYVLRGGEESMARTFGSTAHGAGRLMSRTQAKKDYWGGDVQTDLREQQHVYVKADSGATIAEEAPGVYKDVDEVVRVSDALGIGDRVARTFPVCNVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E6</accession>
    <name>R4W9E6_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">L593_07470</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="term" value="F:acyltransferase activity"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="281" mass="30587" checksum="E9A921BF30420E60" modified="2013-07-24" version="1">MDPEEPEPLPEGWTEGTVRSNGIDVHYTRTNDGTSDDPPFVICHGVFDDGPCRTPLAREFADEFDVVLVDARGHGRSDAPAEGYAMAERVADLGGVIEALELADPILFGHSMGGDTVAATAAAHPDLPRAVVMEDPAGMLAHEESPEELAAWASDRIEFWHGHSKAELLDADEEISSYVADGRAELARRLADARLRVSARISAVFASGWVDTGETYSEIRVPTLILKADGDDAERERNREHASHLPDVELVHVDGTGHTVFRDDRETATKELRAFLDGLVE</sequence>
</entry>
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    <accession>R4W9G2</accession>
    <name>R4W9G2_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="11006at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="556" mass="58866" checksum="59D834A936E34D0F" modified="2013-07-24" version="1">MYNVPFQTTHVRWLLIAVLAVAAIGLLGGGVAASDAATGVTTAEATQDGEDPLVASCAAEMPSDYADPAGGTSGTIGWVDGYWYDEPIDVTASDGLSEAELERLTARTSARAEALRCLTFEEVPPVEVVSREEYANTTGEQFANVSADARRFDNAMLSTMLLVGQTNDSVGVREDSRSQTVAGYYSIEDDRIVVIEQEGTGSAVDETVLVHEVGHALQDQHFDIQRPSNVTMDRDNGLLGLIEGDVSWLENQYLDRCEAGRWAQSCVTLESAGGNGTGGSGGASASAPPNWGLYLEQFQPYSDGPTFVRSIYREGGWAAVNETYADVPRSALYVISPETYGEVELVEPEITNDSRGDWERLTVPGAPADERPGPAGIGGMVIAPTYETSGARNVVSPMGILNYGPDGNVSDFDPLNYDQPPVEGWRGGRMAVFERGNGTATVWRTAWTDGEEAQEFADAYEQLLAIHDAAAVEGREGVFRFNQSSDHSGAVAIVVEGDQVRIVTAPSVDALEDVSPALRSGGGGGSGEGLPVPGFGIAVALLAAIASAGLLVRRQR</sequence>
</entry>
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    <accession>R4W9I0</accession>
    <name>R4W9I0_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">L593_07945</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07945"/>
    <dbReference type="EnsemblBacteria" id="AGN01534">
        <property type="protein sequence ID" value="AGN01534"/>
        <property type="gene ID" value="L593_07945"/>
    </dbReference>
    <dbReference type="GeneID" id="16182263"/>
    <dbReference type="KEGG" id="sali:L593_07945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1628"/>
    <dbReference type="eggNOG" id="arCOG02866">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172273_2_0_2"/>
    <dbReference type="OrthoDB" id="113217at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="83" mass="9309" checksum="19D7C4879DF8F38B" modified="2013-07-24" version="1">MSATTQPSNDGAPAKEQRLRDYLAEKVREEGVVYFKSKFIADEVGLSPKEIGALMVKLSDSAREISVEKWSYTSATTWRIEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M8</accession>
    <name>R4W9M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress protein 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447697.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14320"/>
    <dbReference type="EnsemblBacteria" id="AGN02803">
        <property type="protein sequence ID" value="AGN02803"/>
        <property type="gene ID" value="L593_14320"/>
    </dbReference>
    <dbReference type="GeneID" id="16181184"/>
    <dbReference type="KEGG" id="sali:L593_14320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2931"/>
    <dbReference type="eggNOG" id="arCOG01617">
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        <property type="component" value="Chromosome"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="39163" checksum="51F516271CF61A27" modified="2013-07-24" version="1">MRYRELGDTGLEVSEVAFGAWVVGTDWWGDRTHQDDLDLIETALDAGINFFDTGDVYGHGDSEAIVGEALADHRDDVVVSTKVGYDFYNNPQAGHGELPKKIEPDWVETALDRSLERLDFEYVDLLMLHNANADEVDADVLETLDRLQESGRVESVGWALGPSIGWLAEGEAAAEADVDALQTVFNLFEQEPGQHFLEQIDAHDASTSLLPRVPHSSGLLNEQVTPDTELGEGDHRAHRPDEWYETGWEKVEQIRFLERDGDRTLAQASIQWLLYHDAVASVTPTFRSAEDVEAWAAASEVPPLSDEEYERVQDLYAENFAIDRDDGMDALRTSVDGEDIEAAGLDKEPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N6</accession>
    <name>R4W9N6_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Peptidase S54, rhomboid domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="AGN02828.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_14445"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="21872" checksum="7FCAC472066041B4" modified="2013-07-24" version="1">MIGESDFYRRHPLTTAMFVLCLALYPFILLSIVLWGIDTVAYWFIFSPGLTPEPSWILSLFAHVSPAHLFVNVGALLLLGSYLEERIPRTHLFLVFIATGLGSGLLHANLTGTTGAGASGAILGWGGLYSVYFLSREWTGEATDRWEAFRFAIAVALPFAVAAEFVLGSLTGLTTANHAHLWGMVLGLLIGWPYLRWIQ</sequence>
</entry>
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    <accession>R4W9P5</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08670</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08670"/>
    <dbReference type="EnsemblBacteria" id="AGN01679">
        <property type="protein sequence ID" value="AGN01679"/>
        <property type="gene ID" value="L593_08670"/>
    </dbReference>
    <dbReference type="GeneID" id="16182505"/>
    <dbReference type="KEGG" id="sali:L593_08670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1777"/>
    <dbReference type="eggNOG" id="arCOG04725">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095571_0_0_2"/>
    <dbReference type="OrthoDB" id="66643at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="22772" checksum="2EBF78873FE44924" modified="2013-07-24" version="1">MDEKTEELRDIFMDVTDSDTVTESQAATKGSLTDDEAARERLADLVAEMRDRYDFETELTDGQLCELAVSFYDGASDADLARELDVERRTVFRARLDLHLVRERDLDAPFDVEAFRKRVTSGGEDVATSDLADEFDVSESTVRRYRRVVEAQDESRRANDRYRDEFDSILGDADLAGPLTQEARQDGLDDATEGMETDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q6</accession>
    <name>R4W9Q6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Biotin operon protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_14820</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02898">
        <property type="protein sequence ID" value="AGN02898"/>
        <property type="gene ID" value="L593_14820"/>
    </dbReference>
    <dbReference type="GeneID" id="16181492"/>
    <dbReference type="KEGG" id="sali:L593_14820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3027"/>
    <dbReference type="eggNOG" id="arCOG06241">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072022_0_0_2"/>
    <dbReference type="OrthoDB" id="42750at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="38740" checksum="6277157781151EAA" modified="2013-07-24" version="1">MESIDFAVLGTGGIGRRTLEVSQHKDGLDAVAACDRHGVAIDHDGLDVEELLDATEGNIAGDGRGDTDSEPLTDGGVRHDDETAASASDVKQHGEDAGVVASKQAEPTDAPIDDVVAASDAFDAVLIALPNLEHDFIPRIADRFADANYEGVLIDVLKRSRVIDMLDVRADRFEDSGITFVCGAGATPGFLTGAAALAAQSFVEVESVDIWWGVGLKSGYEDNRGTVREDIAHLDGYDVETARDLSEEEIEEIVDDHNGVLEFHDMEHADDVLLERAGICDAEDVSVGGVLDLRNDEKPTTTTVEVTGTTFDGETGTNTFELDDDTSMAANVNGPALGYLQRAVERNRAGDYGVYGPAELMPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S7</accession>
    <name>R4W9S7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">MarR family transcription regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08970</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446633.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08970"/>
    <dbReference type="EnsemblBacteria" id="AGN01739">
        <property type="protein sequence ID" value="AGN01739"/>
        <property type="gene ID" value="L593_08970"/>
    </dbReference>
    <dbReference type="GeneID" id="16182590"/>
    <dbReference type="KEGG" id="sali:L593_08970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1840"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109676_0_0_2"/>
    <dbReference type="OrthoDB" id="83667at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21427" checksum="89AD900BA0C517CD" modified="2013-07-24" version="1">MTDRGVDEDKRATLRRFAALGATIPAGLAASGSAAAEGSDAREALVGYLSATPGAHFSKVRDDLRLGTGETQHHLRQLIDDGAIVREDDGDYARYYPAATFSAPERTALAALRKETPRAMVLALLREPGQSGASLAESVGVSRPTISRQAASLEADGLLERDDGYRLQQPETVLALVVRYADSFDADAVALAGEADGLIAFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X8</accession>
    <name>R4W9X8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="5" type="ORF">L593_10170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446873.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10170"/>
    <dbReference type="EnsemblBacteria" id="AGN01979">
        <property type="protein sequence ID" value="AGN01979"/>
        <property type="gene ID" value="L593_10170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182712"/>
    <dbReference type="KEGG" id="sali:L593_10170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2096"/>
    <dbReference type="eggNOG" id="arCOG01223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_5_0_2"/>
    <dbReference type="OrthoDB" id="93412at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="164" mass="18099" checksum="303E3227C1FF1B4C" modified="2013-07-24" version="1">MDVALGGTFDPVHDGHRALLEHAFSLGDVVVGLTTDELAPETRNVDRYVRPFEERKADLEAELAAIAEERDRSFDVRPLDSPTGIAAEDPSLEYLVVSPETAPVGEHINELRAERGLEPLTIEVVDHVLAEDDEIISSTRIVQGEIDEHGTLTPERSGRDPQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA57</accession>
    <name>R4WA57_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Methenyltetrahydromethanopterin cyclohydrolase</fullName>
            <ecNumber evidence="4 10">3.5.4.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Methenyl-H4MPT cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mch</name>
        <name evidence="11" type="ORF">L593_12155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin</text>
            <dbReference type="Rhea" id="RHEA:19053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58018"/>
            <dbReference type="ChEBI" id="CHEBI:58337"/>
            <dbReference type="EC" id="3.5.4.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MCH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.27" evidence="4 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447268.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12155"/>
    <dbReference type="EnsemblBacteria" id="AGN02374">
        <property type="protein sequence ID" value="AGN02374"/>
        <property type="gene ID" value="L593_12155"/>
    </dbReference>
    <dbReference type="GeneID" id="16181594"/>
    <dbReference type="KEGG" id="sali:L593_12155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2501"/>
    <dbReference type="eggNOG" id="arCOG02675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876031_0_0_2"/>
    <dbReference type="OrthoDB" id="31274at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018759">
        <property type="term" value="F:methenyltetrahydromethanopterin cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00486">
        <property type="entry name" value="McH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003209">
        <property type="entry name" value="METHMP_CycHdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02289">
        <property type="entry name" value="MCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03120">
        <property type="entry name" value="one_C_mch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="310" mass="32792" checksum="1B38C40320602ECA" modified="2013-07-24" version="1">MESLNRTALELVDEALEFAGELDIGAHELDNEATVLDFGVEFSGGIEAGLLLAEIQSAGLATVQSHVDEVGGAPIPHVELTSDQPGLALLGAQKTGWEVSVDDYEALGSGPARALVAEETIFDRLGYTDVFEFAVLALESDELPTEAVAEHVADLADVEPGAVFLPTYPTASLVGSVTVAARAPELAAFRLAELGYDPTKLVSVSGAAPVAPIAGDEETALARTNDALAYGGQVHLVVEEDFDRFEELPSTAGEEYGQPFYEIFEAADWDFYDLPADVFAPAQVTVDVVGGPTYALGERDEDLLVESFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS13</accession>
    <name>R4VS13_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00225"/>
    <dbReference type="EnsemblBacteria" id="AGM99999">
        <property type="protein sequence ID" value="AGM99999"/>
        <property type="gene ID" value="L593_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.45"/>
    <dbReference type="eggNOG" id="arCOG04402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGM99999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="270" mass="31088" checksum="67C728E96973B6F1" modified="2013-07-24" version="1">MSGADSEPEFQALATFVEDEMSFATSHYNDSYLKRRFTSRIRRTDTEDFGDYHDLLASSEEEQQALLDALSINVTGFFRNPDVWEGIREHLRELFEERSIVRAWSAACADGREPYSLSLLAHDDPRCDPERLRIRATDINEESLDHAREGRYENTRTVDVGEQLQFLSNYHSYVEQSGDQFRMRQATKAPISFEKHDLINDPSKSEFDVVMCRNLFIYIDNEYKQPVLSTIADSMRSGGYLVIGKAETIPPALQSAFSVVDSKLRIYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS27</accession>
    <name>R4VS27_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444914.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00325"/>
    <dbReference type="EnsemblBacteria" id="AGN00020">
        <property type="protein sequence ID" value="AGN00020"/>
        <property type="gene ID" value="L593_00325"/>
    </dbReference>
    <dbReference type="GeneID" id="16182119"/>
    <dbReference type="KEGG" id="sali:L593_00325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.65"/>
    <dbReference type="eggNOG" id="arCOG01301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068376_1_0_2"/>
    <dbReference type="OrthoDB" id="91726at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="20283" checksum="5598E1A9CDF8D33B" modified="2013-07-24" version="1">MAHVIVVGGGPAGLSAALFAEKNGLDVTVFDTDGTWMHNAHLFNYPGVGSIDGTSMMENLRAQVDSFGVDRHQDEEVTDVAAAGEGFTVTTDDGEYDADYVVLATGANRDLAESLGCSFDGDVVDVDVTMETSVEDAYATGAMVRAEEWQAVISAGDGAAAALNVLTKEKGEHFHDFDTPDTATETFGSFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTV3</accession>
    <name>R4VTV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445549.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03520"/>
    <dbReference type="EnsemblBacteria" id="AGN00655">
        <property type="protein sequence ID" value="AGN00655"/>
        <property type="gene ID" value="L593_03520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180580"/>
    <dbReference type="KEGG" id="sali:L593_03520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.714"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_2"/>
    <dbReference type="OrthoDB" id="18921at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050401">
        <property type="term" value="F:xylonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034624">
        <property type="entry name" value="Xylonate_dehydratase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00564">
        <property type="entry name" value="xylonate_dehydratase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="167"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="414" mass="46012" checksum="44430A17AB7EA79E" modified="2013-07-24" version="1">MSNDIDYTDLHDPNAEYTMRDLSAETMGVTAKRGGGRDVEITDVQTTMVDGNFPWTLVRIYTDAGIVGTGEAYWGAGVPEVIERMKPFVVGENPLDIDRLYEHLIQKMSGEGSVEGITVTAIAGIEVALHDLAGKILEVPAYQLLGGKYRDEMRVYCDCHTEEEADPQACAEEARRVVDELGYDALKFDLDVPSGHEKDRANRHLRPGEIRHKAEIVEAVTEEVKDEADVAFDCHWTFSGGSAKRLAEAIEDYDVWWLEDPVPPENLEVQEEVTKSTTTPITVGENRYRVTEERRLIENQAVDIVAPDMPKVGGMRETRKVADVANQYYVPVAMHNVSSPVATMASAHVGAAIPNSLAVEYHSYELGWWEDLVEEDVIEEGYIEIPEEPGLGLTLDEDAVAEHMVEGETLFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU47</accession>
    <name>R4VU47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445609.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03820"/>
    <dbReference type="EnsemblBacteria" id="AGN00715">
        <property type="protein sequence ID" value="AGN00715"/>
        <property type="gene ID" value="L593_03820"/>
    </dbReference>
    <dbReference type="GeneID" id="16180692"/>
    <dbReference type="KEGG" id="sali:L593_03820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.775"/>
    <dbReference type="eggNOG" id="arCOG03073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_1_1_2"/>
    <dbReference type="OrthoDB" id="125081at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="101" mass="10796" checksum="39ED73916994FEE5" modified="2013-07-24" version="1">MTVAIEAYLVLSAAVFSCGLFGVLTRRNALVFLISVELMLNAANINLIAFSHFYGNATGQVFALFTIGLAAAEVAIGIGIILVLSRNFGEADVTLPTEMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU82</accession>
    <name>R4VU82_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable L-aspartate decarboxylase</fullName>
            <shortName evidence="3">ADC</shortName>
            <ecNumber evidence="3">4.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mfnA</name>
        <name evidence="5" type="ORF">L593_04020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the group II decarboxylase family. MfnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445649.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04020"/>
    <dbReference type="EnsemblBacteria" id="AGN00755">
        <property type="protein sequence ID" value="AGN00755"/>
        <property type="gene ID" value="L593_04020"/>
    </dbReference>
    <dbReference type="GeneID" id="16182413"/>
    <dbReference type="KEGG" id="sali:L593_04020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.817"/>
    <dbReference type="eggNOG" id="arCOG00027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_2_1_2"/>
    <dbReference type="OrthoDB" id="44488at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01610">
        <property type="entry name" value="MfnA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020931">
        <property type="entry name" value="MfnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03812">
        <property type="entry name" value="tyr_de_CO2_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="38099" checksum="C737B04EF0F95C2D" modified="2013-07-24" version="1">MRAEPQSFDRVLSSMCTEPHPAAREAAETFLATNPGDPATYPAIADLEADVVDRLGEITSLADPHGFVASGGTEANIQAVRAARDRSDSRDPNVVAPETVHFSVRKAADVLGVELRTTPVDADYRAEPAAIDAATDADTALIVGVAGSTEYGRVDPIPALGEVATDTGAMLHVDAAWGGFVLPFTDYEWDFAVEAVDTLTIDPHKLGQAAIPAGGLLAREKATVDALAVETPYLESTTQATLTGTRSGAGVASAAAALDALWPEGYRETYERQQALAEWLAGEFEDLGFDVVEPSLPLVAADLDASLFDSLREEGWRVSRTRAGELRIVCMPHVTREMLESFLADVRALQPRAAPAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUB3</accession>
    <name>R4VUB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445684.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04195"/>
    <dbReference type="EnsemblBacteria" id="AGN00790">
        <property type="protein sequence ID" value="AGN00790"/>
        <property type="gene ID" value="L593_04195"/>
    </dbReference>
    <dbReference type="GeneID" id="16180862"/>
    <dbReference type="KEGG" id="sali:L593_04195"/>
    <dbReference type="eggNOG" id="arCOG00608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OrthoDB" id="102704at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="185" mass="19909" checksum="A46B4AD2C78C4C3E" modified="2013-07-24" version="1">MELPTPEDLKQRRKSDEIDLTQAELADAADVSQPLIARIEGGDVDPRLSTLRRIVQALDEEETGVTRAADLMTEDVATVAPDDSVQEAEDRMDEAGFSQLPVVRDESPEGLISHTAIREASSETDSPVGELPVSEVMDESISQKGLDATLDEIDSSLDHNKAVMVVSKGKLQGLITEADIAAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUN8</accession>
    <name>R4VUN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444870.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00105"/>
    <dbReference type="EnsemblBacteria" id="AGM99975">
        <property type="protein sequence ID" value="AGM99975"/>
        <property type="gene ID" value="L593_00105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180932"/>
    <dbReference type="KEGG" id="sali:L593_00105"/>
    <dbReference type="eggNOG" id="arCOG03888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071225_0_0_2"/>
    <dbReference type="OrthoDB" id="89405at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="34604" checksum="3D8BC4763C085BB0" modified="2013-07-24" version="1">MSWSRSSKLGLAVLLLFVLAAVGVASAVSVTPEQAPEEAEVGQNVTIQVELQDLYAESSSWNFDGQTVLENATWTVEEYQGSNQVDTHTFQGQSPPNGEVTIDQSASDAPDRLVVEISGTVPIVDSYSYENPATFLGAELVRVASDGSGFTTIQEYQIHHYTTDDPGSAEARTALDDARSTIDAAASDGSDVSEAESTFDDAVSAYDSGNFADAVSLAEESASQAESSSSDGGSGSDDSGSSDDGSTDGGSTNGTDTTGGDTGDQSGSDGSQTDSSQTSDGGQDADGNSSSNDSDDGGLLMPILYALLGALILGVIVGGFYWYQQQNQGPNRDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ0</accession>
    <name>R4VUZ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_05530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445949.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05530"/>
    <dbReference type="EnsemblBacteria" id="AGN01055">
        <property type="protein sequence ID" value="AGN01055"/>
        <property type="gene ID" value="L593_05530"/>
    </dbReference>
    <dbReference type="GeneID" id="16181407"/>
    <dbReference type="KEGG" id="sali:L593_05530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1130"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_2"/>
    <dbReference type="OrthoDB" id="31316at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="11">
        <location>
            <begin position="50"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="37697" checksum="ACB03062E8B5D581" modified="2013-07-24" version="1">MNAYSIAKPLLFRLPPEAAHHVVHRGLRVAQATPLERLLRWRYCVEDERLEVDEFGLEFPAPVGVAAGFDKNARIPRALAALGFGHVEVGGVTAEAQEGNPRPRLFRLPEDRALVNRMGFNNDGADAIGKRLDESRLPDVPVGINIGKSKSTPLADAADDYAYTYEAVADAGDYFAVNVSSPNTPGLRELQDRGPLVDILSRLQEEGASPLLVKLSPDLSEAATEDALEVVRDLDLDGVIAVNTTTERDESLRSQNAAESGGLSGAPLEHRATERVRFVADRVDVPVIGVGGIASAEGAYRKLRAGASVVQLYTGLVYEGPTIASEINRGLLELLERDGFASVEDAVGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV75</accession>
    <name>R4VV75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_01090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445065.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01090"/>
    <dbReference type="EnsemblBacteria" id="AGN00171">
        <property type="protein sequence ID" value="AGN00171"/>
        <property type="gene ID" value="L593_01090"/>
    </dbReference>
    <dbReference type="GeneID" id="16180713"/>
    <dbReference type="KEGG" id="sali:L593_01090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.223"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="229"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="41069" checksum="5383E24495C86B88" modified="2013-07-24" version="1">MTFRLSDEHRAIRTAVREFGENEIEPVAAEHDRNKKYPEELRRKAAEYDFVGSSIPPEYGGAGMDALGSMIVTEELWRADPGIGSAVGSASFGTNMILRFGDEWMKEEWLPQIAAGETASASAISEPAHGSDVAGMETTAEKDGDEWVIDGNKMWITNGTVAGVAVVMAKTTPDAGHKGITAFLVPTDTEGFTAEKIDNKLGIRASDLAELILDDVRVPEENVIGEVDAGFYQLMEFFAVGRTGVAAQAVGCAQGALDAAMEYANEREQFGQKIKEFQAIEHKLADMATQVEAARSLTYRAASEIEKGNQDVAAKYSSMAKLFASEVAVNVADEGVQVHGGSGFVTDYPAERYYRDARITKIYEGTSEIQKNIIADQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVE8</accession>
    <name>R4VVE8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">egsA</name>
        <name evidence="15" type="ORF">L593_01290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445105.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01290"/>
    <dbReference type="EnsemblBacteria" id="AGN00211">
        <property type="protein sequence ID" value="AGN00211"/>
        <property type="gene ID" value="L593_01290"/>
    </dbReference>
    <dbReference type="GeneID" id="16182315"/>
    <dbReference type="KEGG" id="sali:L593_01290"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.263"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OrthoDB" id="57545at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
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        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="37127" checksum="95B9EF9609CA695C" modified="2013-07-24" version="1">MFDKSTWIRLPRNVVVGHGVVDDTVEAVADLHLHGQPLIVTSPTPRELAAERIAADFAADGEDPVIVEVQEANFDAIEHVIDRAREVEPGFLIGVGGGKPIDIAKMAAEEIDRGFVSVPTAASHDGIVSGRASVPDQGTRHSIAAEPPLAVVADTEILADAPWELTTAGCADIISNYTAVLDWRLARRLKNVSYSEYGAALSEMTAEILVDNADSVRPGLEESAWVVVKALVSSGVAMSIAGSSRPASGAEHLFSHQLDRIAPGAALHGHQAGVGSIVTAYLHAGERGMWSDIRNALDSIDAPTTAADLGVSDEQVVEALTTAYEIRDRYTILGDGLEESAARQAASYTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVF6</accession>
    <name>R4VVF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445115.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01340"/>
    <dbReference type="EnsemblBacteria" id="AGN00221">
        <property type="protein sequence ID" value="AGN00221"/>
        <property type="gene ID" value="L593_01340"/>
    </dbReference>
    <dbReference type="GeneID" id="16179856"/>
    <dbReference type="KEGG" id="sali:L593_01340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.273"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_0_2"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="30899" checksum="A6D94BE6B59F683A" modified="2013-07-24" version="1">MSDLQTALTGETPPLVTPFDADGNVDHDALAAVVDHVESNGVTGLFPCGTTGEFASLTDEEQLAVTETVVEVSSPDIPVVAGVSATAIDDAVAKAEAAATAGADAAVLTPPFFHTSDDQTGIEEFFATVADRSPLPIILYNIPVYVGTSLDTETVASLAERPDVIGVKDSSGDLDYTLDLLRETPDDFLVLQGWDTLLVPGLRMGIDGGVNALANVVPEVFAVLVDEPESERARAASDAIADLFDVCLDVGFATASKAALVQRGVIDSDAVRPPLSAVPESAYDRIDEAVDDARDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVH4</accession>
    <name>R4VVH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_01465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01465"/>
    <dbReference type="EnsemblBacteria" id="AGN00246">
        <property type="protein sequence ID" value="AGN00246"/>
        <property type="gene ID" value="L593_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.298"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="6">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="7">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="19345" checksum="D4068ADEA5B2B6FE" modified="2013-07-24" version="1">MVARYEGASVRTSLNVPDDLLAEFDEVWQAQGIENRSRAVREAMLEYVEAHTRLEDVEDELVALVGFDYRHHDVIQELHGVQHQFQDVIINTSHTHQGDLCLESLFCRGDADRIHGLTNELRDFDAVRRVKVMVIPDGAEHEHPHPHEHVHDAGEAHDHGENGDHDHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVS1</accession>
    <name>R4VVS1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LmbE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446194.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01300">
        <property type="protein sequence ID" value="AGN01300"/>
        <property type="gene ID" value="L593_06765"/>
    </dbReference>
    <dbReference type="GeneID" id="16181461"/>
    <dbReference type="KEGG" id="sali:L593_06765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1382"/>
    <dbReference type="eggNOG" id="arCOG03460">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_1_2"/>
    <dbReference type="OrthoDB" id="79462at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="233" mass="25523" checksum="349E2AE5D52E4DE6" modified="2013-07-24" version="1">MDLLAIVAHPDDAGIFCGGTLAKHADRGDSVTVAHMTRGEYGGFEQSEDEIAATRTEEALAAGDVMGIDEVDFLGFEDGRIEYSLENRMRIVEAMREHEPDLVLTHFGDDMHPDHCRTSQLVSDAYYMAGLPKVETGQEPADPDNVYFFGKPTSAFEPTVFVDVGDYLETKIEAVAEHESQLEYLQDHGGIDAEFDNLLDSLRAEARSLGTRASAPAAEGFAPLHEQPIEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVY5</accession>
    <name>R4VVY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445320.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02375"/>
    <dbReference type="EnsemblBacteria" id="AGN00426">
        <property type="protein sequence ID" value="AGN00426"/>
        <property type="gene ID" value="L593_02375"/>
    </dbReference>
    <dbReference type="GeneID" id="16181459"/>
    <dbReference type="KEGG" id="sali:L593_02375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.482"/>
    <dbReference type="eggNOG" id="arCOG02546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289620_0_0_2"/>
    <dbReference type="OrthoDB" id="44682at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="4">
        <location>
            <begin position="156"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="521"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="609"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1058" mass="110486" checksum="FC7AE5C1E520E00D" modified="2013-07-24" version="1">MERTRRGILRSVSVLSALAVGASATASAADCSSAPAWDETVLYSSGDQVQHPDGDGIDVLWKAELDSRNAEPSRSSSYWNYVGDCSGDTNTAPTASFTTDVSTPEPGQDVSFDASGSGDSDGSIASYSWDFGDGSSATGQTATHSYSSTGDYDVILTVTDDDGASDTSTKTVSVTDGSTNQSPNASFTVTPADPGTGETVTVDAADSSDSDGTIASYEWDFGDGTTASGQTASHSYSSTGDYSISLTVTDDDGATDSNTTTVTVSDSGSGGQCEGVPAWDSAATYTGGDQVTHDGALWTAEWWTQGTEPAESENVWTLEGDCSGGNETPTASFTTDVSTPEPGQQVGFDASGSSDSDGSIASYSWDFGDGSSATGQTATHSYSSSGDYTVTLTVTDDAGATDSASTIVSVSEQATQITIDSSVDGWVGVTPSEIDGQTNPAIDLVSGEPYAFTWNNVDGVPHNLTIRNAAGDALLQTETVGEAGQSRTLEFTPTEEMVEYICSIHPQAMVGDLAIDGNQPPTATLSVDPTNPSPGQSVSFDASGSTDSDGTISSYEWTFGDGATGTGQSASHTYSDAGEYTVQVTVTDDGGAAAIASSTITVGDPNQGPTASFTTSPSSPDPGQSVSFDASGSSDSDGTISSYEWDFGDGTTATGETATHTYADGGSYEVTLTVTDDAGATDSTTSTLGIGGDVSASTTLSEFYSAYDEDFNHEYTEGGVSGLLKNELNPDASEFGADVDAISNNAGDGSMELGSLGDRGLELVKRFDADGVPRETTGRLMAWLTGLPTQTEPVPFNDGEGRDGGLTADAGPVSATNDPSVLVQDTWPRGEQFDDVYLQPQRVDWSSSVSDSQYTNTDNPIIDAVKDKVHPVTGETLGSGFTSNAPLEATAELHDDGWIFDMSMIFKNTTDVPVLIDGAIMWWVGPEKGAAGLDQFSYDNRERKNYSVGHPQRDVIEVSLPNAKKPGPFEGTDAPLSAYGIRVAHHDNPYQYRTLYPNQKFAMTYHNVTGPGQYDWPLQDLVDVMLDTCHVEFREEMSSIDTNTELVDAIDARNRYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW07</accession>
    <name>R4VW07_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prs</name>
        <name evidence="6" type="ORF">L593_07265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446294.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07265"/>
    <dbReference type="EnsemblBacteria" id="AGN01400">
        <property type="protein sequence ID" value="AGN01400"/>
        <property type="gene ID" value="L593_07265"/>
    </dbReference>
    <dbReference type="GeneID" id="16179984"/>
    <dbReference type="KEGG" id="sali:L593_07265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1483"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OrthoDB" id="59314at2157"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_A">
        <property type="entry name" value="RibP_PPkinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037514">
        <property type="entry name" value="Rib-P_diPkinase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="139"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="30724" checksum="9E921CBF1549A3FA" modified="2013-07-24" version="1">MIVSGSTSQSLAATLATELDEPLAVVEQTAFPDGESKFAIDAPGERTLADVDRAVIVASTTTADAHLEVLQLQDAAREAGIDEVVTVLPYMGYGRQDRAFETGEPVTARAIARALSPGTDRVLTVTPHEPAVCDFFDPPATQIDAEALLAEPLRSDPDPALDEPLFLSPDAGAIDVAETVRDAFGSGEVDHFEKTRTSGTEVTIEPGNAEIAGRDVVVVDDIVATGSTMSQSIEVLQDRDVGRVFVGCVHPLLARDARSKLARAGVEAIHATDTIERLVSTVSAAPAIAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW24</accession>
    <name>R4VW24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_02575"/>
    <dbReference type="EnsemblBacteria" id="AGN00466">
        <property type="protein sequence ID" value="AGN00466"/>
        <property type="gene ID" value="L593_02575"/>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.522"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HerA-like"/>
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        <property type="entry name" value="HerA_central"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="36812" checksum="C9808D041B5C989D" modified="2013-07-24" version="1">MTVVIGRETDGDAAPTASLGQYRALDGSEGAAVELDLDRPHAALVVGKRGYGKSYTLGVLAEELARTAGVAPVLIDPMGVFDSLADGRQDPPVEVDVVPAPTVAPSMLDPRAWCALLGLSPESGAGALVWQAARDATTLGDMQSAVESSDAPADDCLAAANHLALAEEWCVFDPDGLDRRLLGTAEATVIDVSGLDAAPMNAVVRGVAEGLYRARVDESIERLPWLAIDEAHTFFEGVAQSALETILTRGRAPGVSLVLATQRPGVIPEVAISQSDLLLAHRLTDERGLAALEDAQPTYLSGTLEERLPTEPGEVLAIDDATESVHALHVRERETPHGGESPRSSETTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWI2</accession>
    <name>R4VWI2_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03450"/>
    <dbReference type="EnsemblBacteria" id="AGN00641">
        <property type="protein sequence ID" value="AGN00641"/>
        <property type="gene ID" value="L593_03450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180546"/>
    <dbReference type="KEGG" id="sali:L593_03450"/>
    <dbReference type="eggNOG" id="arCOG02021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_3_2"/>
    <dbReference type="OrthoDB" id="116946at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="15505" checksum="1C14B2F2E0C70B99" modified="2013-07-24" version="1">MVREVDPDEVQSKLASDDEEVTVVDIRSPRQFALGHVPGAINVPLPELPRRVDAYDWDADEVVAVCPHGESSIQAARLLGSYEGIHADAVASLAGGYREWDGDLETGAPASETAAPAAEADGGTNDEGPEARDEGPEARDEGPEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWM1</accession>
    <name>R4VWM1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445570.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03625"/>
    <dbReference type="EnsemblBacteria" id="AGN00676">
        <property type="protein sequence ID" value="AGN00676"/>
        <property type="gene ID" value="L593_03625"/>
    </dbReference>
    <dbReference type="GeneID" id="16180598"/>
    <dbReference type="KEGG" id="sali:L593_03625"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536726_0_0_2"/>
    <dbReference type="OrthoDB" id="81179at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="18875" checksum="5D6FE10FF3C918A0" modified="2013-07-24" version="1">MASERSTTDGNLGIDEFERHVEDLDRDRVEILDCSGNDGLGAARGANQHVSTPADLTGISIGMAKQFKALPTHRLDGLRYGLDSVSTLLQFLDVQTVFKFLHVYTARVEDTDGLGVVTFTGEAHDAQARNTILGQFDAVIRLRETDAGDREVQIRGDGVAPTGWIPFPYGSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWR9</accession>
    <name>R4VWR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20-type chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08700"/>
    <dbReference type="EnsemblBacteria" id="AGN01685">
        <property type="protein sequence ID" value="AGN01685"/>
        <property type="gene ID" value="L593_08700"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08700"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="16581" checksum="C5A2247D98233899" modified="2013-07-24" version="1">MNPFTELQRFFERMSEQYDETAEAWSFDEPFGELALGAESMATDLVERDEAYVVAVDLPGFERDDVDIQVTDSTLRIDAERETEVAEEGERYVRRERQEQSAHRSIELPAEVEKDEVTATMENGVLTITLPRAEVEEAHHIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX84</accession>
    <name>R4VX84_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ORF">L593_09475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446734.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09475"/>
    <dbReference type="EnsemblBacteria" id="AGN01840">
        <property type="protein sequence ID" value="AGN01840"/>
        <property type="gene ID" value="L593_09475"/>
    </dbReference>
    <dbReference type="GeneID" id="16182860"/>
    <dbReference type="KEGG" id="sali:L593_09475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1951"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_2"/>
    <dbReference type="OrthoDB" id="57901at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="65"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="42690" checksum="CB3A5F055056B2AA" modified="2013-07-24" version="1">MHPPGASTVLLRYGDLTTKSHAVGGRMRDRLGGHLEALLDARDLDATIDVGHARTILDTEPAEVEAVARTAADVFGAVSASPALAVEPTKLAIESALREAAAAHYDGGTFAVEARRAHDGHPFTSEDVGRFGGDAVGEGAPEGVEPRVDLDDPDLTFEVEVRESVAYVSLDRIEGPGGLPYGTQAPLVALISGGIDSPVAAYEVMRRGSPIVPVYLDLGDYGGADHEARAVETVRKLAWHAPQDDWELYRVPAGESVAAIADALDRGRMLAFRRYTVAVAEAIAREHDAAGIVTGEAIGQKSSQTVRNLAITDAATELPVHRPLLSWDKDRISNQARALDTFAESTIPAGCNRFAPDNAETGGSLGRIRETEPTDLFERAKTDAADADAIRIDPAAPADWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX99</accession>
    <name>R4VX99_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446754.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09575"/>
    <dbReference type="EnsemblBacteria" id="AGN01860">
        <property type="protein sequence ID" value="AGN01860"/>
        <property type="gene ID" value="L593_09575"/>
    </dbReference>
    <dbReference type="GeneID" id="16181524"/>
    <dbReference type="KEGG" id="sali:L593_09575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1971"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_0_0_2"/>
    <dbReference type="OrthoDB" id="104702at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="28239" checksum="5D0163486961C40E" modified="2013-07-24" version="1">MAGEAVSAFVPGHVTGFFAVHEADDPMAAGSTGGGIALADGVTVTVRYGDRETYLDDTSAPIAPVERVREALDVDATVLVESALPPGCGFGVSGAAALGTALAAAKSFELEYSENELISLAHGAEVKAGTGLGDVVAQAKGGIVLRTEPGAPGEGSLDRIPARETVEYLAMDELSTADVLDGDTEELSEIGEQCLQLVRSEPTVETFALASRRFAREAELLTPDVGEAIQGANEAGGDASMAMLGETVFCFGTGLTDAGYDAERTEIDPAGASLLR</sequence>
</entry>
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    <accession>R4VXJ9</accession>
    <name>R4VXJ9_9EURY</name>
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            <taxon>Natrialbales</taxon>
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    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00986.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043899">
        <property type="entry name" value="DUF5789"/>
    </dbReference>
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        <property type="entry name" value="DUF5789"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="97" mass="10545" checksum="E42DFA894F9016A1" modified="2013-07-24" version="1">MSEDDAEDEEAEEPAVELGEQTPVEGAPLARVTARLHFPLQKSEIQRREGGSTIRTPSGPRTVTDVLADVETTYFATDDEFRSTVEDVIGTGPVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXP6</accession>
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    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01036">
        <property type="protein sequence ID" value="AGN01036"/>
        <property type="gene ID" value="L593_05435"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05435"/>
    <dbReference type="HOGENOM" id="CLU_3394553_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="31" mass="3433" checksum="1DC8EEC2F0C9EC95" modified="2013-07-24" version="1">MGFLLFGIGMHLHLLHLNLVKQLRAEGSDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY95</accession>
    <name>R4VY95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_11375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447114.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02220">
        <property type="protein sequence ID" value="AGN02220"/>
        <property type="gene ID" value="L593_11375"/>
    </dbReference>
    <dbReference type="GeneID" id="16180947"/>
    <dbReference type="KEGG" id="sali:L593_11375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2345"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093378_0_0_2"/>
    <dbReference type="OrthoDB" id="97382at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="21310" checksum="95A2932002365F31" modified="2013-07-24" version="1">MSSTASESEPIDPDEQLTTSDDDHAGTAEQGEPEPLSLDVVYDILKNTRRRRVLHLLYEDEEGTTLGDLAERIAAVENDKPRSQLDAQERKRVYVGLYQCHLPRMDDAGVVDFDGDRGTVELGTHAEQVYGHLVSAEDDSESRDWSTYYGLYGIGGVLAGLALGWTAPMAAQLFVVGLLVAGAVVLAGVHLLAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYT6</accession>
    <name>R4VYT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HpcH/HpaI aldolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_12430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12430"/>
    <dbReference type="EnsemblBacteria" id="AGN02425">
        <property type="protein sequence ID" value="AGN02425"/>
        <property type="gene ID" value="L593_12430"/>
    </dbReference>
    <dbReference type="GeneID" id="16179946"/>
    <dbReference type="KEGG" id="sali:L593_12430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2556"/>
    <dbReference type="eggNOG" id="arCOG04974">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_4_1_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="28"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="28072" checksum="AD30989965D76883" modified="2013-07-24" version="1">MAKVHRTNELAAALANDDVALGLLDNTYSPTIVELCGDLGLDFVWLDLEHGGPDPWDGPTITNLLRAAERTGIEPLVRLPDTDPTLVRKALDLGVRSLFLPRVDTADEVREAVRSARFRYQDGAGDRGLAGPRASRWGLAEDYVAAEDDETLVGVTIETREAVENLEEILDVPELGFVFVGPFDLSVSLGHPGEREQPDVQEAVESIRSRAISAGVPVGGLGFGMEDVNEKAADGYQLLHLGSTTGVLQTAVGDWLDAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYV1</accession>
    <name>R4VYV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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            <end position="29"/>
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        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25830" checksum="EC437B9398F95A06" modified="2013-07-24" version="1">MPVTPTTSGDIGISIIGLLSLVLTVLPVTPTTDRDLLLIDLSITLISQTLSGFLTAIDSLLLHLSLYLVQLLVPSHDVLHRWAMIRPFDCHRLRIITGFERNLLRVCLGFPLSNGNGITRSFFPIGPTTGRDIDIGRLDLLDSPLHPVSEFPLDSPVARGLFEEVLQNRLDGSLLIWIQSVILPDPYLELLHRRVSLRFDEIPENVLQDFDLLRSDVHLIGISDIVVPLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ78</accession>
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            <fullName evidence="3">tRNA(5-methylaminomethyl-2-thiouridylate)-methyl transferase</fullName>
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        <name evidence="3" type="ORF">L593_08055</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="312" mass="33258" checksum="E77C8222B8B0C7D8" modified="2013-07-24" version="1">MTTAAEKAAAARESIAERDGGVLIAFSGGVDSAVVAALAHDALGDDAVACTAKSETLPAAELDDAREVADAIGIRHDVVEFSELDSPDFVANDEDRCYHCRTMRLGRMYEHAKELGIETVCDGTNASDPGEGHRPGLEAVAELDATSPLLDHDISKEEVREIAAQYDLPVADKPSMACLSSRIPTGLEVTEERLTRIEKAERLLRTWGFDQFRVRDHDGLARIEVGEDELEIALDTGFAQAAREHMLDLGFDHVTLDLQGYETGSVSPGDDAAEAGPTGEASAGAEDDAATAAGDDEPLVEDVFDVDYPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZU5</accession>
    <name>R4VZU5_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">DUF2061 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">L593_14180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02775.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02775">
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        <property type="gene ID" value="L593_14180"/>
    </dbReference>
    <dbReference type="GeneID" id="16181118"/>
    <dbReference type="KEGG" id="sali:L593_14180"/>
    <dbReference type="eggNOG" id="arCOG08188">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160691_3_1_2"/>
    <dbReference type="OrthoDB" id="121527at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF2061_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09834">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2061" evidence="2">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="8224" checksum="A9282E8FD8F879DF" modified="2013-07-24" version="1">MSDSLLGGANQRLSRSVAKTLGYRVLMLAITITVAFAVTDDVVAALNIGVITNVVKTGTYFGYERLWARISWGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W052</accession>
    <name>R4W052_9EURY</name>
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        <recommendedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14780"/>
    <dbReference type="EnsemblBacteria" id="AGN02890">
        <property type="protein sequence ID" value="AGN02890"/>
        <property type="gene ID" value="L593_14780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181476"/>
    <dbReference type="KEGG" id="sali:L593_14780"/>
    <dbReference type="eggNOG" id="arCOG02916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025850_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="634" mass="66664" checksum="1A13177ED2D8B5E7" modified="2013-07-24" version="1">MRLLDDERGQSVQVGAAILLGFVVIAITIYQVEVVADQNAEVEFNHNEEVRQDLTELRNAISNAGSQGVSESVSVKLGTQYPPRTIFVNPPPVHGQIVTRPVGNLSFGNAQVEGSYDGNAAGLVNGNHSTSRIVYVPRYFELDDGGTTILEHSLAFNVFQNNATNAMTGQGIVSGDRLTLTVLQGNYAEQGTGSVSLDPTTVSGPTDPITITNASSGPIELYLPTRTPGVWNETLGTTFGDDDARVAGYDGQRITVQLDRKEYQLRMALVGVGSGVNGTDRYAIHSPSSNGSDSRDSRYSLNWRDPSGQTGTQEPCDADACTWNVSADTDSQLNITAETVPSLDGVDVDFAVNESAIANVSGDGETTSGTNTATLSAQGMNGTVGVYAISGDGSDLINISIRYAGSNTPANTGPSADFTWSCTGSSCSFDGSSSNDPDGSIVSYDWNFGDSSTGTGSSTSHSYSPPGTYNVSLTVTDDDGATDTVNKTISSGGGISFGQTSTWSTYESVVQQDLSSIRNDEVTIVSVKVNDTPNRVSQLDGTRLGYPEVELYDNNGQVGFADAPSGYTLPADMSLAADGSTAPFPSSSSLTLYLTEFQNNGGNPRNMQGESITITLTYRVNGLTYTSTQTVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0I0</accession>
    <name>R4W0I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal-transducing histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10405"/>
    <dbReference type="EnsemblBacteria" id="AGN02026">
        <property type="protein sequence ID" value="AGN02026"/>
        <property type="gene ID" value="L593_10405"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10405"/>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="16735" checksum="098CF96FF11574DC" modified="2013-07-24" version="1">MGATEADDRHVSEEIGFDDQLLVGGALGGVLAGVLMGLLMHYRMGIMEVVGGLYSVESVTAGWIFHLVHAVLFGVFFAIGLQWRPFAKYDFGPLAIALLGLAWGVALWMVAAGVIMPLWLDAMALPAPDLPNWATKSGTGHLVYGATLGVVVAIADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0I8</accession>
    <name>R4W0I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446930.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10455"/>
    <dbReference type="EnsemblBacteria" id="AGN02036">
        <property type="protein sequence ID" value="AGN02036"/>
        <property type="gene ID" value="L593_10455"/>
    </dbReference>
    <dbReference type="GeneID" id="16181730"/>
    <dbReference type="KEGG" id="sali:L593_10455"/>
    <dbReference type="eggNOG" id="arCOG04673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1615280_0_0_2"/>
    <dbReference type="OrthoDB" id="102330at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="155" mass="16463" checksum="54DD3C5B0DC8D2A7" modified="2013-07-24" version="1">MLGPPIDAWYVWIGVSLVSLAVLGVAVVATPEPLSNAEAAAETIEQVDSSRPPATATHDIDAERVRIGEYRLVLEGEDTERATIDHGRMAAAPRGTDLRRVALGASPESVFASEWAFGEAVEAARSEQRIVEPAGDRLVVRKVSYGGSNVLLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1A1</accession>
    <name>R4W1A1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">L593_12065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447250.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12065"/>
    <dbReference type="EnsemblBacteria" id="AGN02356">
        <property type="protein sequence ID" value="AGN02356"/>
        <property type="gene ID" value="L593_12065"/>
    </dbReference>
    <dbReference type="GeneID" id="16180808"/>
    <dbReference type="KEGG" id="sali:L593_12065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2482"/>
    <dbReference type="eggNOG" id="arCOG00081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_1_0_2"/>
    <dbReference type="OrthoDB" id="54384at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="272" mass="29384" checksum="DA8218692C520B66" modified="2013-07-24" version="1">MNCFDRLADRVAAADSLLCVGLDPDLDRLPPAVQDHDLPRWAFNRRIIDATAEHAAAFKPNAAFYEDPDGWRALEETLAYAEGKGVPVVLDAKRADIGNTARQYAKLLDSADAITANPYMGEDSLQPFLSHREAATFVLCRTSNPGGEDLQSLELEDGDQVYERVADLAAEWDDGNVGLVVGATAPEELEEVRDRVPELPFLVPGVGAQGGDAEAAVEYGTASAGPYEGVGLVNSTRGIIFAYEDANVPADRFEEAAASAARSLKRRLNRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1M7</accession>
    <name>R4W1M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk potassium uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447425.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12960"/>
    <dbReference type="EnsemblBacteria" id="AGN02531">
        <property type="protein sequence ID" value="AGN02531"/>
        <property type="gene ID" value="L593_12960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180270"/>
    <dbReference type="KEGG" id="sali:L593_12960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2657"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_2_2"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="22913" checksum="12A1022EB2E55AE3" modified="2013-07-24" version="1">MPRSLDVVIAGAGRVGRQAATILTDRGDDVTVVERDPDVCDDLADEWLTTIIQGDSANPDVLEQAGVEDADVVAALTGETGVNLATCMACSELSPEIRTVARIDRADAQSYTRFVDAVVFPERAGAHVAVNQIVGSDVQTLADVTATLDIMQIRVAEGAPAANKQLAEVRFPTGTLVISDDEGERVARSDTTLTPGNRYVVAVEPGVVDEVLNLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1N0</accession>
    <name>R4W1N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447430.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12985"/>
    <dbReference type="EnsemblBacteria" id="AGN02536">
        <property type="protein sequence ID" value="AGN02536"/>
        <property type="gene ID" value="L593_12985"/>
    </dbReference>
    <dbReference type="GeneID" id="16182773"/>
    <dbReference type="KEGG" id="sali:L593_12985"/>
    <dbReference type="HOGENOM" id="CLU_2191134_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="11104" checksum="9E6B87A2444B2F31" modified="2013-07-24" version="1">MRPDRRSVVAGAALLGVAVLALLDPLGLRAAIGSWFRVAGPASGSTRAIGASIQRRHATVDSLEAALAADPTLSLALLATGIGVGLIGGSIAAYLHQRRRIRRGERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2F2</accession>
    <name>R4W2F2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proB</name>
        <name evidence="9" type="ORF">L593_14625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447755.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14625"/>
    <dbReference type="EnsemblBacteria" id="AGN02861">
        <property type="protein sequence ID" value="AGN02861"/>
        <property type="gene ID" value="L593_14625"/>
    </dbReference>
    <dbReference type="GeneID" id="16181365"/>
    <dbReference type="KEGG" id="sali:L593_14625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2986"/>
    <dbReference type="eggNOG" id="arCOG00864">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_0_0_2"/>
    <dbReference type="OrthoDB" id="96284at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="286" mass="30712" checksum="F56B0E2781FDA51A" modified="2013-07-24" version="1">MSDTVGTDDEVESVSAETADAARKLAADAERVVVKAGTNTLTDDESNLDVEKVAKLVDDVNDLLERDREVLLVSSGAVGAGKGRVDYPNDTVEESQALSTVGQSQLMAEYSDSFDRYDRTVAQILLTENDLEDTERFTNFTNTVETLLEWDVVPIINENDAVATEEIRIGDNDMLSSSVAIGVGADLLVTLTDVGGVYTANPKEDDAAERIEVVGNNYAEVQQLVDRSSSATFGGIQTKVHGAREVSEHEIPAIIAKSTEPDVLEQIVTGKPVGTLFVPTNGETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J4</accession>
    <name>R4W2J4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="7" type="ORF">L593_14910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447810.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14910"/>
    <dbReference type="EnsemblBacteria" id="AGN02916">
        <property type="protein sequence ID" value="AGN02916"/>
        <property type="gene ID" value="L593_14910"/>
    </dbReference>
    <dbReference type="GeneID" id="16181571"/>
    <dbReference type="KEGG" id="sali:L593_14910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3045"/>
    <dbReference type="eggNOG" id="arCOG04611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006051_3_0_2"/>
    <dbReference type="OrthoDB" id="6076at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="453"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="599" mass="63909" checksum="4AC0C3913109803D" modified="2013-07-24" version="1">MTAPNRNTRWAEILIDELYEGGLESVCISPGSRSTPLTVAAYEHDDLTVFSHLDERSGSYFALGRARRTAEPVGLICTSGTAAANFHPAVVEANQARVPLVVLTADRPPELRDSGANQTIDQEKLYGDAVRWYRDLPEPDTSDRTLRRLRVDAARAVASATDAPAGPVHLNVPFRKPLEPVEVPEDQPTNPDGLGVTGRDGSFVDATDAVLAPSPDAIDELAERVADVDRVLLVAGPADPGLGAGAEARSLASTTGAPLLADPLSDARFGSSRSETGDSVLICGGYDAYVGTEPVASWPEPEVVVRFGASPTSKPLRKYLAGTDAWQVLIDPTTDWREAEFTAAATIRADPPRALEALTSALRERGVDPLAPERVAYRERFASAESEHWSLVDDARDETPFEGAVVPSVLGALPERTSVFASNSMPVRDLDRFAEPDDRSISAFANRGASGIDGILSTALGVASAGEEPLVAIVGDLAFYHDMNGLLAAQRCGVDATIVVVNNDGGGIFHALPIESFDPPFTEAFKTPHGLDFEPTGDLYDLQYDRVASVDALAAACARSVGTDGVDVVECRFDAETSHRTRESLQERLAQRLSERAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J5</accession>
    <name>R4W2J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444891.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGM99996">
        <property type="protein sequence ID" value="AGM99996"/>
        <property type="gene ID" value="L593_00210"/>
    </dbReference>
    <dbReference type="GeneID" id="58789319"/>
    <dbReference type="KEGG" id="sali:L593_00210"/>
    <dbReference type="eggNOG" id="arCOG08109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444709_0_0_2"/>
    <dbReference type="OrthoDB" id="96659at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="21243" checksum="683A01241F2E9975" modified="2013-07-24" version="1">MSASSDALDGETVEATLLEAEIIEPTTDGDDHRVAAAVMDALDQEYYRMANPNAEREQLRTLLGDAITLDAGSDEPHFEAEEIDDGFELRREGTTSGRWPSRLAFRTDLAFSSVLEDRIDDWDDLASAQRGDLLSGTRLFLDTCPDCEASLSFRVTEPGSEASQASTSDDSASHEVALLACGDCEETLFVGDAVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2K7</accession>
    <name>R4W2K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444906.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00285"/>
    <dbReference type="EnsemblBacteria" id="AGN00012">
        <property type="protein sequence ID" value="AGN00012"/>
        <property type="gene ID" value="L593_00285"/>
    </dbReference>
    <dbReference type="GeneID" id="16180779"/>
    <dbReference type="KEGG" id="sali:L593_00285"/>
    <dbReference type="eggNOG" id="arCOG10152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142273_1_0_2"/>
    <dbReference type="OrthoDB" id="104836at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="DUF326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="13094" checksum="F6FEC443B7703D2B" modified="2013-07-24" version="1">MSFAETVSRIETLTEEERECIELCNEAVEVCEWCADECLGDAEMEECARLCRDVTDVASLHARFMARDSQYSAHLAELCAEACEACAEECSKHDADHCQACADVLPECAENCRNMASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2L2</accession>
    <name>R4W2L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_15035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447835.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15035"/>
    <dbReference type="EnsemblBacteria" id="AGN02941">
        <property type="protein sequence ID" value="AGN02941"/>
        <property type="gene ID" value="L593_15035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180857"/>
    <dbReference type="KEGG" id="sali:L593_15035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3071"/>
    <dbReference type="eggNOG" id="arCOG02890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_2_2"/>
    <dbReference type="OrthoDB" id="28939at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="33931" checksum="4E213D338A183903" modified="2013-07-24" version="1">MTSLGSATAAPGELDTGRLVVGETRDGSEFGLPVAVINGAEDGDTLYLQAASDGDELNGVGVLQRVVPRIDPAELRGTILIVGIVNYHAFQVAEHRNPIDDTKMNRTYPGDAEGTSSERIAAATFDVASSADLVLDLHQGSTSRMIDEVRVRCGTRHRLHDQCLELAKAFGCGYVLDQKGPDGQLAREGPDAGVPTVDPELGGCVGWDEQSIQAGVDGVFNVLRYYDFLEGSVQPAQQTRANSFEQYGAPCGGLVSMAVDLGDHVSQGDTLFTITDVFGQTKETVTANEDGICWRTRRLPQVATGEYVCSIGTEVDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3H4</accession>
    <name>R4W3H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="8" type="ORF">L593_02905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445426.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02905"/>
    <dbReference type="EnsemblBacteria" id="AGN00532">
        <property type="protein sequence ID" value="AGN00532"/>
        <property type="gene ID" value="L593_02905"/>
    </dbReference>
    <dbReference type="GeneID" id="16180376"/>
    <dbReference type="KEGG" id="sali:L593_02905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.587"/>
    <dbReference type="eggNOG" id="arCOG01306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_2"/>
    <dbReference type="OrthoDB" id="30571at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="182"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="45356" checksum="B556CBB60E8971C1" modified="2013-07-24" version="1">MSDTAEEVDFPYDEQEASLSDKIEALQERLEVLESQNEEMRDKLLDANAENNKYQQKLERLTHENKKLKQSPLFVATVQEVTEEGVIVKQHGNNQEMLTEVTEELRERLDPDSRVALNNSRSIVKALDDETDVRARVMQVEESPGVTYGDIGGLEEQLLEVRETVEMPLTKPGDFETVGIEPPSGVLLHGPPGTGKTLLAKAVAEETDATFIKMAGSELVHKFIGEGAKLVRDLFQVARDHEPAVIFIDEIDAIAAKRTDSKTSGDAEVQRTMMQLLSEMDGFEDRGEIRIIAATNRFDMLDRAILRPGRFDRLIEVPKPNEEGRRKIFEIHTRDMNVADDVDFDVLATMAEDASGADVKAVCTEAGMFAIRDDRTEVRETDFREAWRKVQADESDEGVSKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3M0</accession>
    <name>R4W3M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03305"/>
    <dbReference type="EnsemblBacteria" id="AGN00612">
        <property type="protein sequence ID" value="AGN00612"/>
        <property type="gene ID" value="L593_03305"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.669"/>
    <dbReference type="eggNOG" id="arCOG02920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="7">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="28636" checksum="2BB93A3C4AADE0DE" modified="2013-07-24" version="1">MAITPLTRIREVADPDPQNQGVVTSSQTPNSPDGSDRIGGFKRDQSRASGCMKRRDFLRTAGGAAGAATAASAAASPASAEGGVSAIQDDGGNTTQSGGNQTDTGGNQTDGGNQSAGGGLPGAGQTQTITAGPGGELVFDPADVEILPGTQVVWEWDSDTHNVVPDGQPEGANWEGHTPVENTGFTYSHTFTVEGTYDYYCEPHRSAGMEGSITVTADAGGGAGGGGYEPPDPEHMGIPIQKHFVGALAFMGIFVTLVFTFYLLKYGESAHTAAPNKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Q0</accession>
    <name>R4W3Q0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445561.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03580"/>
    <dbReference type="EnsemblBacteria" id="AGN00667">
        <property type="protein sequence ID" value="AGN00667"/>
        <property type="gene ID" value="L593_03580"/>
    </dbReference>
    <dbReference type="GeneID" id="16180605"/>
    <dbReference type="KEGG" id="sali:L593_03580"/>
    <dbReference type="eggNOG" id="arCOG06255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418664_0_0_2"/>
    <dbReference type="OrthoDB" id="130665at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="23131" checksum="065974AFB2D71215" modified="2013-07-24" version="1">MPDTPTEPDDESDADTGATRADSTAGEDESAAPTTVAPAGQDDVNRRWLIRLLVALGIGIPILVEGATLLRMLRSFLLGGGGGGGNESDSGGDPDTAVEIGDEILPETPPPEILRRAVVVSGENVWEFQARIRVENTGEDPYTFRVSALRTDEGKRIADPVATERLAPGEPQTLDHTWRMPAGERPASFEVLASTETATGTERVERTVELGSFPLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3U2</accession>
    <name>R4W3U2_9EURY</name>
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        <submittedName>
            <fullName evidence="7">NADH-ubiquinone/plastoquinone oxidoreductase chain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445616.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03855"/>
    <dbReference type="EnsemblBacteria" id="AGN00722">
        <property type="protein sequence ID" value="AGN00722"/>
        <property type="gene ID" value="L593_03855"/>
    </dbReference>
    <dbReference type="GeneID" id="16180694"/>
    <dbReference type="KEGG" id="sali:L593_03855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.782"/>
    <dbReference type="eggNOG" id="arCOG01557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_1_1_2"/>
    <dbReference type="OrthoDB" id="101537at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15571" checksum="7270A7D6FFCAF200" modified="2013-07-24" version="1">MSDWIAIGALALVAVGIPLGMMGLSALLRPRVPERHKTATYESGEVPTGTTKIRFNIQYYMVALLFVVFDVETVFIFPWLAIYREAIGEVGLARALVPMLFFLSILVIALVWAWRNGAVEWARSPRATVRARREDQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W407</accession>
    <name>R4W407_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00837.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00837">
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        <property type="gene ID" value="L593_04430"/>
    </dbReference>
    <dbReference type="GeneID" id="16180935"/>
    <dbReference type="KEGG" id="sali:L593_04430"/>
    <dbReference type="eggNOG" id="arCOG03065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_4_0_2"/>
    <dbReference type="OrthoDB" id="115195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12839" checksum="FDF060022F04BD41" modified="2013-07-24" version="1">MSTDGTSDLLDLLGEARNREILAATSRETLSAKELSEECDVALSTIYRRVDEMVEHDLLVERTRIESDGSHHSVFDANVDRVGVDVGDGTIEVSLHVREDAAERFSRIWSHIRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W445</accession>
    <name>R4W445_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04790"/>
    <dbReference type="EnsemblBacteria" id="AGN00907">
        <property type="protein sequence ID" value="AGN00907"/>
        <property type="gene ID" value="L593_04790"/>
    </dbReference>
    <dbReference type="GeneID" id="16181091"/>
    <dbReference type="KEGG" id="sali:L593_04790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.979"/>
    <dbReference type="eggNOG" id="arCOG00962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_0_2"/>
    <dbReference type="OrthoDB" id="88832at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_3" evidence="2">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="294" mass="33827" checksum="7A2FCF7B8541BF8B" modified="2013-07-24" version="1">MSTEQEEAADGAADAQQTEIESVQSPGDRRRAEKHARMQVTEEERAATEAAAEETTHLKVFRFDPEVPEKEEPRFDDFHVPYVQGMTALDALIYARDEFDSSLTFRHSCRQAVCGSDALFINGSQRLACKTQLSALDEPVRIEPLPHQDVVKDLVVDMEHFYDQMEAVEPYMQSEEFPEGELEEQRQSPENREKIKMATRCIWCGACMSSCNIAAGDNEYLGPAAINKAYRFAMDEREEEEIKEHRLRIMEQEHGVWRCQTQFSCTEVCPKDIPLTEHIQELKREAVKSNLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W466</accession>
    <name>R4W466_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04965"/>
    <dbReference type="EnsemblBacteria" id="AGN00942">
        <property type="protein sequence ID" value="AGN00942"/>
        <property type="gene ID" value="L593_04965"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04965"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149784_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="27070" checksum="43010BA432D00D3D" modified="2013-07-24" version="1">MDWFSNTIPQGTVFTTHRIATEIPGLISELADQHEIGVHVHPKEFGYDHDQLAELPPNVQSEVISSTRGAIADAIGVDPDSIRSFRAGRHSASEATIEILRDLGFLVDASVNMRYTQHLPSSITQRSKPFNWDGIFEIPTTFDKIPLFSRYGLRGTVTATANTLKTDRLLCSGTKAIKYLLSATDFVSFYMHPFDAISNNNQGGAEFRQRVERLFSTSDDKIQYITASEYARLRLDSLSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4W3</accession>
    <name>R4W4W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_07100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07100"/>
    <dbReference type="EnsemblBacteria" id="AGN01367">
        <property type="protein sequence ID" value="AGN01367"/>
        <property type="gene ID" value="L593_07100"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1451"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="41"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="317" mass="32867" checksum="F65E447272FC5EEE" modified="2013-07-24" version="1">MSADSTAASSAGGTDVVENRSPAIEERPQRAPGAGALGDTWISVKRWLVKTSRNPFVTFTSLVQPVIFFVLMAEVFGAVAGGALASAVGTDVNYVTYLTPAIVVQSALAAASISGIGLVIDMDSGMFEKTLASPMGRGAMFLGKVFAEVVRIVVQTTIILGCGAVLLFLETGDGPGTFLETGVAGFLGVLAITILFAGAFMAFSNIVALVTRDKEATILIANSLTFPLLFVSSAFLPLQVLPDWINTVATVNPITYGVDGVRAAMLGEDVMTVVDVAAFGGVWNTIVPAIVVLVAFNVVLGAIAVRLLHRASRAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5D1</accession>
    <name>R4W5D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446556.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01662">
        <property type="protein sequence ID" value="AGN01662"/>
        <property type="gene ID" value="L593_08585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180527"/>
    <dbReference type="KEGG" id="sali:L593_08585"/>
    <dbReference type="eggNOG" id="arCOG11470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075538_1_0_2"/>
    <dbReference type="OrthoDB" id="85709at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="2">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="2">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="24441" checksum="928B086AD682931F" modified="2013-07-24" version="1">MARNLTGRIATGGLVILIGILLLLSTTNTVPTDSLWDWVPAIFVLLGAWALLSSGFRNLTGPVMVIAIAGAFLARNLELIGESAIDTWWPLFLVLFGVLLLIGRQRRSRIHTEIGEDGELTTIAIFGGSERRITTDRFAGGEVVVAFGGAEIDLTDAEIDRPPATIEAVVLFGGAEILAPDDWNVKLDVLPLFGGASDERKRPDEAPRRGDGPDLVVTGVALFGGIEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W7</accession>
    <name>R4W5W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444927.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00390"/>
    <dbReference type="EnsemblBacteria" id="AGN00033">
        <property type="protein sequence ID" value="AGN00033"/>
        <property type="gene ID" value="L593_00390"/>
    </dbReference>
    <dbReference type="GeneID" id="16181415"/>
    <dbReference type="KEGG" id="sali:L593_00390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.79"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="306" mass="33129" checksum="DF1F80B32F5A8446" modified="2013-07-24" version="1">MAAIDCSGLTKRFGDVLAVDDLDLTVEEGEIYGFLGPNGAGKSTTIDILLDFVRPTSGDVTVLGHDAQDEGELVRQKTGVLPDAYHVYDRLTGRQHVQFACEMKGVDDDPIALLERTGVAEAADRKAGGYSKGMRQRLVLAMALVGDPELLILDEPSTGLDPNGAREMREIIQAENDRGATVFFSSHIMEQVEAVCDRVGIINKGSLVADNSIDGLRNATETGEVLFVTLDRIDESVRQQVAALDGVADVAIDDGRIRLSVADRSKFRVLESIDDGVAPVQDFEVVESSLEDLFVRYTTDAQEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W602</accession>
    <name>R4W602_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00088.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00088">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04085">
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    <dbReference type="OrthoDB" id="28752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="38552" checksum="4F60FE991CFAF723" modified="2013-07-24" version="1">MPTEYGASYFGVRNRTHAETDLDRFQEEGLNAVLHTFSERDHRYYEGTMQDIVAASKDRGFEVYVNPWSVGRVFGGEALSQFIGEHPECQQVTSEGNNVATACFNAPEFREYMREWTEAAAGLGADVLFWDEPHWFIPEWFEEEFEDDEWGCRCEHCQARYEDEYGEPMPEEQTEQVREFKADQLTAFLDEMMQLTRENGCENAVCLLPSEDEEHGLSDWDQLAANEYLDVLVTDPYWAIFPEAEGPEEFVGYFSEKVADMAEKYDLRSQIWIQGFRLPAGSTEEVKTATRTAIEAGVDSVMMWGYDGCKSISDIACEEPDDVWNGFLEEVQAAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W661</accession>
    <name>R4W661_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1333523.L593_01125"/>
    <dbReference type="EnsemblBacteria" id="AGN00178">
        <property type="protein sequence ID" value="AGN00178"/>
        <property type="gene ID" value="L593_01125"/>
    </dbReference>
    <dbReference type="GeneID" id="16180936"/>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.230"/>
    <dbReference type="eggNOG" id="arCOG01622">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="37938" checksum="6ABCF538FD3BA646" modified="2013-07-24" version="1">MDQDTPRIGFVGLGNMARHHVDNLLDQDVEIAAGVDVVPEAREAFADDFGAETFEDVDAMCEVVDAAFVVTPNRFHEDAAVTILENDVALYQEKPLAHTLESAERIANAAADSDAIAMVGLHNRFNGGAEVLDAYRQEGRFGDVSHVEIEYVRRRGIPAIGTWFTDKSTAGGGSLIDIGVHAIDLGLHLAGHPDVVEVSGTARSEFGDRDDTADMDIWGTPDPDGVFDVDDSASAFFRGDDGTTFSLEVAWASNREPAQSVTVRGDDGGATLDLSSGETTIYEDGTAGIDHVSDAAIETKSRDAHAACQRAFLEGLRTGEQPERNTVEQALTVQQVIDGIYRSSEADAAVRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W680</accession>
    <name>R4W680_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445087.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01200"/>
    <dbReference type="EnsemblBacteria" id="AGN00193">
        <property type="protein sequence ID" value="AGN00193"/>
        <property type="gene ID" value="L593_01200"/>
    </dbReference>
    <dbReference type="GeneID" id="16182526"/>
    <dbReference type="KEGG" id="sali:L593_01200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.244"/>
    <dbReference type="eggNOG" id="arCOG04802">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121761_0_0_2"/>
    <dbReference type="OrthoDB" id="104975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="16258" checksum="4F925FE7795CEEE5" modified="2013-07-24" version="1">MAPADAPLSVETVLVPVDGTDQATKAAEYAIAIADRYDADVTAVYVLAETISRAIEREAVDHETVAEESQSYLEGLTETAAASGVALDATVAYGFSKTKKSQHPGSVVLDTADEIGADFLVIPREDQHEDERDTLAKAAEYVLLYASQPVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W687</accession>
    <name>R4W687_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L6P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl6p</name>
        <name evidence="4" type="ORF">L593_11185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447076.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11185"/>
    <dbReference type="EnsemblBacteria" id="AGN02182">
        <property type="protein sequence ID" value="AGN02182"/>
        <property type="gene ID" value="L593_11185"/>
    </dbReference>
    <dbReference type="GeneID" id="16182040"/>
    <dbReference type="KEGG" id="sali:L593_11185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2307"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OrthoDB" id="80629at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="3">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="3">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="21816" checksum="9FC38F1EEFBDF7DA" modified="2013-07-24" version="1">MPRTELPIPEDVDVEIDHLDVSVSGDNGSVSRRLWYPDVSVSIETVEVVADGADESAEDPDTESVDAVVIESDADDAKTMSTLGTFESHVSNMFHGVSDGWTYEMEVFYNHFPMQVSVEGEEVVIENFLGERAPRRAPIHGDDTQVQVDEEEITVSGPDKEAVGQTAADIEQLTRVNDKDVRVFQDGVYITQKPSKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B0</accession>
    <name>R4W6B0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01550"/>
    <dbReference type="EnsemblBacteria" id="AGN00263">
        <property type="protein sequence ID" value="AGN00263"/>
        <property type="gene ID" value="L593_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.315"/>
    <dbReference type="eggNOG" id="arCOG06262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097418_0_0_2"/>
    <dbReference type="OrthoDB" id="81547at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045396">
        <property type="entry name" value="DUF6517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20127">
        <property type="entry name" value="DUF6517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22279" checksum="D8F31875380C6C92" modified="2013-07-24" version="1">MGAIAATAGCLDFILGDDLSFSASEASVSDAALRETDYEQRRTKKQSFEKSFEVGGESRSVEVTNVYAEYDRSIDLSVVGLGDQRAATFTAAATPKVDVLGQSFNPIKDMSPAEIIGRAQNRYDGFGNLRQRSELTVSLLGKEANVTRFTGDAELSNMGQTVEIELQVSEAVGSGDDYVLAVGGYPRRLSDRGRASYETLAGGVQHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F6</accession>
    <name>R4W6F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445247.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00353">
        <property type="protein sequence ID" value="AGN00353"/>
        <property type="gene ID" value="L593_02010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180023"/>
    <dbReference type="KEGG" id="sali:L593_02010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.409"/>
    <dbReference type="eggNOG" id="arCOG00524">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_0_0_2"/>
    <dbReference type="OrthoDB" id="82365at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="25829" checksum="932C51A4A41F4E63" modified="2013-07-24" version="1">MTAVLIAYATGEGQTAKTAEAIAETLGDADLDVAIRNVAVEPEVDLRTYDAVVVGSPVNNRAHLPAVVEWIDANRDALVDRLSAFFQLSIAGVSESDWAVDSTREWVDDLVEQTGWTPDRVGDFGGALAYSQYGPVERQLFRVAAAFATGDTDTSRDYEYTDWDEVAAFAEEFAALVAAPADEDVPRAFAYEPPSAAASGPSQNRLRQVAVVAIVALVVAAIVAALYRRCSGADREAAVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L7</accession>
    <name>R4W6L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447296.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12315"/>
    <dbReference type="EnsemblBacteria" id="AGN02402">
        <property type="protein sequence ID" value="AGN02402"/>
        <property type="gene ID" value="L593_12315"/>
    </dbReference>
    <dbReference type="GeneID" id="16179882"/>
    <dbReference type="KEGG" id="sali:L593_12315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2533"/>
    <dbReference type="eggNOG" id="arCOG02327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="352"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="556" mass="59682" checksum="14CD812E68A990D1" modified="2013-07-24" version="1">MEFLGLDGSFVAFLAYVVAFGLAGVVCLVSIPKAASISDADTRRGLISLLVLCGGWAMVHVGFLVAPTRELQTGFYVAGLAVGFAATGAWLYFCSAYTGRTLHRNPYFRWIAVGVYVGVIALKFSNPLHGLYFSTTMASMPFTHLAIHHGTLHWVAMGLAYALATVGYFMLLERFLAVGEDTRPLTLLVGLTGLPLAVDVLGRLSPRLLDMTYEPLGVAAFAVGVLYLYFEEFRAVQIAGSSEDPVIVLDVDGVVREYNRAAADLFPDLASGIGTPLREVVPSVQEVIAGENDILTIRREDGIAHYRITRTQMGTGDAPAGSMLTIEDVTAAEESRRALEREKERLDRFASVVAHDLRNPLNVADGRLDLAVESLEHDGYSGDGGHPETAEHLDAIDDALERMEALIDDLLTLARQGQDLDEIESVSIGSFAEDCWGTVDGPAATLVSADDPTIRADPERLRQLLENLFRNAIEHGGEDVTITVGSLDGDAGFYVEDDGPGIPAADRTDVFEAGMTTNPDGTGFGLAIVEEIADAHGWDVSATAADDGGARFEIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z7</accession>
    <name>R4W6Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-keto-3-deoxy-phosphogluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03535"/>
    <dbReference type="EnsemblBacteria" id="AGN00658">
        <property type="protein sequence ID" value="AGN00658"/>
        <property type="gene ID" value="L593_03535"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03535"/>
    <dbReference type="eggNOG" id="arCOG01090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="22885" checksum="2118C26C35411AAD" modified="2013-07-24" version="1">MAAFKPPAVATTNMVNDTLQRIEEAGVVAVLRGVEPDTVEQVAEAIVEGGVTALEVTADSHDAMDMIETLTETVGDDALVGVGTVLDSETTRAAIAAGAEFVVCPTFDRGVVETCNRYGVPVAPGVFTPTEAQQAYEAGADVVKVFPAKSGGPGHVSALKGPLGHLNVIPTGGVGPSNAGEYVEAGAMAVGAGGAILDHDAVDAGDYEQLTENAAALVRAVEDARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C4</accession>
    <name>R4W7C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14390"/>
    <dbReference type="EnsemblBacteria" id="AGN02817">
        <property type="protein sequence ID" value="AGN02817"/>
        <property type="gene ID" value="L593_14390"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14390"/>
    <dbReference type="eggNOG" id="arCOG08168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500342_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="179" mass="19017" checksum="A79E8B659E3063DC" modified="2013-07-24" version="1">MLGLLLAALLATAAVPSPALAQAQNQTAAQDAPEGYEERVDEWVILTDWRYDSSENRFLLTFESERTVRVTISEVVSKKEAESGTYSVQQRTIENGTTTVEMPADTGPSGEAAVSITTARSLQEGRGVFVSTGQQSSNPFGAFGGTQGLFIGILLACAFALLAALVTLWRENDGVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F7</accession>
    <name>R4W7F7_9EURY</name>
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            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
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        <name evidence="1" type="ORF">L593_04970</name>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04970"/>
    <dbReference type="EnsemblBacteria" id="AGN00943">
        <property type="protein sequence ID" value="AGN00943"/>
        <property type="gene ID" value="L593_04970"/>
    </dbReference>
    <dbReference type="GeneID" id="16181163"/>
    <dbReference type="KEGG" id="sali:L593_04970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1012"/>
    <dbReference type="eggNOG" id="arCOG01377">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
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    </dbReference>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="505" mass="56033" checksum="6835FD3387CEC1D9" modified="2013-07-24" version="1">MPNTVVVGLDGANWDLLQPWLDDGDLPNIASLRNSGVDADLQSCLPPVTCPNWRCYSTGKNPGKLGVYWWEKIDAENRTLSTPNSRSFKSANFWDYLNEDGQTAGVVNLPMSYPPFELDGFMVAGGPGSEQTDYTTPPDLGDELDAAGYDVHPDVAVTSSEDTDAADAVVDLIDQRLETYRRLLDEREVDVAHCTVFYVNVLQHYFWRDEPTYRAWQVIDEHLGAIRQEHPDATLVLLSDHGCDEIDTMFYANTWLEQEGFLHTKTDATSAFERLGINKKRVLKIAERFGAQDLIAKITPEFVKSQVPMDEEGAKREHKLDRVDWSKSRAIASGQGLIYVLDGAESTRDEIMDRLADLESDVSGTPIAREVLTREEAYDGPYVEDAPEIVFDQTPGIHTSGAIGDNPVFEDVSHWRAENVRTGLFLADGPDVTASAVEEPVPITAVAPTVLHSVGCPIPEDVDGMPLALFDGEEPIFRDPITPEFLNRQGSDGVEDRLEDLGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7L6</accession>
    <name>R4W7L6_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_05420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05420"/>
    <dbReference type="EnsemblBacteria" id="AGN01033">
        <property type="protein sequence ID" value="AGN01033"/>
        <property type="gene ID" value="L593_05420"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05420"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06178">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736488_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16301" checksum="5B72A2212EF93F53" modified="2013-07-24" version="1">MTESGEAPNPSDQLSDALIERLDGLEISELKAVVSYAQRRIESIRTPLEDEIRATASGDVLEIENHGAYAIVRKHPDDPDGDGAATHVTSMYHVQRTPHPDGEETLEWRFLGDVHDSEQARCDSCGGTIVGDTAVCPHCGSEQTEESGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S0</accession>
    <name>R4W7S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06020"/>
    <dbReference type="EnsemblBacteria" id="AGN01153">
        <property type="protein sequence ID" value="AGN01153"/>
        <property type="gene ID" value="L593_06020"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1233"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3178736_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="46" mass="5124" checksum="178335830A5544CB" modified="2013-07-24" version="1">MSDADGPKQVDDPNYHNVNHTAAQTCGWTKNALNGEGTCYKHAFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X5</accession>
    <name>R4W7X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06705"/>
    <dbReference type="EnsemblBacteria" id="AGN01288">
        <property type="protein sequence ID" value="AGN01288"/>
        <property type="gene ID" value="L593_06705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1369"/>
    <dbReference type="eggNOG" id="arCOG01270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="37709" checksum="D5EDC0DF2D2F3B16" modified="2013-07-24" version="1">MSGFVAHGATEIVAIASALLPALAGVDAVLPLANLGQLTDLADPTALFGIFLNALSKFGVYVTIAAGLSLIFGLMGVLNFAHGSLTMIGAYLGGAVMLAFVSSSTGDFVTIAFFFLALALVFAIVTAFGAVLEVGVIRPIYDRPPLFQILLTFGLVLVLDEALRIVLEVQDIQPSVEWTEAAGTRPDILGFHDILGVTTRGIYQFEALVGVLVVIATWWFLTRTSYGLHIRAGSEDAEMAQALGIDVRRSFTVVFGVGAGLAALAGVMLMWDPRYGASIGLGVETLLIAFVIVIVGGLGSFKGTVVAAAIVAIVDAVASWMLTNDVVTFAGLPELVIFLVLVGVLVIRPQGLFGVEEVGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y0</accession>
    <name>R4W7Y0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446197.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06780"/>
    <dbReference type="EnsemblBacteria" id="AGN01303">
        <property type="protein sequence ID" value="AGN01303"/>
        <property type="gene ID" value="L593_06780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181872"/>
    <dbReference type="KEGG" id="sali:L593_06780"/>
    <dbReference type="eggNOG" id="arCOG00324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_1_2"/>
    <dbReference type="OrthoDB" id="34461at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="365" mass="38324" checksum="74F57DB4B2D9CF2A" modified="2013-07-24" version="1">MGSPLLVGHAPACLEHDPGPTHTDRPKRVERVVETLEERGATFERPEPLEPDDISAVHTPGYLRWLKETCEDEKRVDHDTVTSAGTWPAVMAAAGAAEWAVERAHEEATRTADEFTAGDESVAGSEPSAGSEPSAGETPVTFAPVRPPGHHALRNRAMGFCFVNNAAVAAERALELDGVDTVAVLDWDVHHGNGTERQFVDRTDVHYVSVHQDGVYPGTGSVDAAGVGDAIGATANLPLPAGAGGPAVRLATEALLDPFLDAAEPDLVVLSAGFDAHEHDPISDLELTTENYGWLTGWARAVAAAHDAPLAIVLEGGYQPGLLAESVDAAAEAIENGTPAAPEGEPTEEARRVIEGAAEIWPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W823</accession>
    <name>R4W823_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446332.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07465"/>
    <dbReference type="EnsemblBacteria" id="AGN01438">
        <property type="protein sequence ID" value="AGN01438"/>
        <property type="gene ID" value="L593_07465"/>
    </dbReference>
    <dbReference type="GeneID" id="16182133"/>
    <dbReference type="KEGG" id="sali:L593_07465"/>
    <dbReference type="eggNOG" id="arCOG04347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718241_0_0_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="20282" checksum="A1A9657648FB9146" modified="2013-07-24" version="1">MSEILAYYDDLAEFYTEIARFPLRQHVVWPATRSLLGDVAGERLLDAGCGTGEHSADLAEEGANVVGLDASEGMLETAREQFGDRQFGGAGADSLAFERANLLDGLPFEDGCFGVVCCQMVLSHVRELGPVLDALVSALLDAGFAIDGIEEPAPDEVFRERWPDAYESYVQRPPDVLCLRGRTPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W848</accession>
    <name>R4W848_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_07715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446382.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07715"/>
    <dbReference type="EnsemblBacteria" id="AGN01488">
        <property type="protein sequence ID" value="AGN01488"/>
        <property type="gene ID" value="L593_07715"/>
    </dbReference>
    <dbReference type="GeneID" id="16182200"/>
    <dbReference type="KEGG" id="sali:L593_07715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1581"/>
    <dbReference type="eggNOG" id="arCOG01351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_2"/>
    <dbReference type="OrthoDB" id="102435at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homoserine_dh" evidence="8">
        <location>
            <begin position="146"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="32839" checksum="48FCEEC354266A2E" modified="2013-07-24" version="1">MRLAVLGAGAVGRSVVELAGEYGHEVVAVADSRSAAVAGGSGGAGSDDALDASAVLERKDSEGVVGDADPEDALAADYDALVEATPTTLDDAEPGFGHCEAALEADRDVVLANKGPVAERYADLRALEAASEGTVRFEATVAGAIPAISTIEDYGPETVEAARGVLNGTANFVLTRMAAEGLGYEHVLAEAQDLGVAEADPSFDVDGTDAALKCVILANVLTGGEPEFSLSDAEVEGIRNVPGSALELAKEEGRTVRLIGEATRDTVRVGPRLVPENGVLAVTGTRNIVQIDTEHAGRLNISGRGAGGPETATAVLADVGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W868</accession>
    <name>R4W868_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Halorhodopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_02090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445263.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02090"/>
    <dbReference type="EnsemblBacteria" id="AGN00369">
        <property type="protein sequence ID" value="AGN00369"/>
        <property type="gene ID" value="L593_02090"/>
    </dbReference>
    <dbReference type="GeneID" id="16180073"/>
    <dbReference type="KEGG" id="sali:L593_02090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.425"/>
    <dbReference type="eggNOG" id="arCOG02811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_5_1_2"/>
    <dbReference type="OrthoDB" id="70686at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <source>
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    <sequence length="278" mass="29636" checksum="3D24DCD4DE110801" modified="2013-07-24" version="1">MISSLSKATLLPLQLGQREVLDHIRDNLLLSASLWINVALAGLSVLLFLYMARDVQSRRTRLIFAATIFIPLVSLSSYLGLISGLTAGFLQMPAGHTLAGEQVLVQWGRYLTWTLSTPLILLALGLLADADTVDLAAVIAADIAMCVTGLAAALTVSSYGFRWAFFGVSAAFFLVVLYALLARWPDSAEGAGTDEIFDTLRTVTVVLWIGYPVVWALGVEGLALVDSTALTSWGYSLLDIGAKYGFAYLLLSWVASNEETVAGGPLSGARGDVSATQD</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="218" mass="24451" checksum="FA3F21305D285CEF" modified="2013-07-24" version="1">MRKRIDLLVRGDDVSHEAFVESWRSTYLPRLRDAEAVVRSQQVLPTQPEHAEFDGLSEVYVESPDALEDGSVPPIDEVLPVAEHRQFTGEETVQRDDVDGDTDGLYKHSAFLVRQDGMSHEAFVDYWQTNHTPIAREIEGVVKYDTVVPTDPASTAFDGVAELYFEDLDALHDALGSEGSRDYDPTKGKAAEAREDVDNFLAVDERPRLIGRNHLVKG</sequence>
</entry>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="AGN01593.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
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    </evidence>
    <sequence length="76" mass="8762" checksum="9C0CB8FC0C6FFD18" modified="2013-07-24" version="1">MPSITVNVDDDLKERMEKHPEINWSEVTRQAIQDKIETLEVMDELTSESELTESDVQEIADKINESGRKRVDEESA</sequence>
</entry>
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    <accession>R4W8A0</accession>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9328" checksum="DCB7CB6AEC2898B2" modified="2013-07-24" version="1">MLSLQLEEFMIELKEGSIKNVGAPNKAATAKLYDVEEAEVRTFGDERLKFSFADAEGNQVDVALSPETAEAIAEAVPDELEALAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B7</accession>
    <name>R4W8B7_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
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    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02765"/>
    <dbReference type="EnsemblBacteria" id="AGN00504">
        <property type="protein sequence ID" value="AGN00504"/>
        <property type="gene ID" value="L593_02765"/>
    </dbReference>
    <dbReference type="GeneID" id="16180326"/>
    <dbReference type="KEGG" id="sali:L593_02765"/>
    <dbReference type="eggNOG" id="arCOG03392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089194_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="188" mass="20488" checksum="C7FFFA83B1B3B524" modified="2013-07-24" version="1">MWPLGHAAGAYLLASVGAERDWLPEPNAVLVVTVLFASQTPDLIDKPFAWYIPILPAGRSFGHSLFFVLPLCLLAVLAARRVGWAGLGLAISAALLSHLALDVIPALWGGGGWRYLLWPVLSVEGFNSAPSIGAMLEDSLDMPYFWAEFVLAGLAFVRWRADDWPGVTWLFERGGTAPTVVRSRQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H0</accession>
    <name>R4W8H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 12 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445538.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03465"/>
    <dbReference type="EnsemblBacteria" id="AGN00644">
        <property type="protein sequence ID" value="AGN00644"/>
        <property type="gene ID" value="L593_03465"/>
    </dbReference>
    <dbReference type="GeneID" id="16180563"/>
    <dbReference type="KEGG" id="sali:L593_03465"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_7_0_2"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="28548" checksum="83708C01BA812717" modified="2013-07-24" version="1">MTDHGYDEQMAAIYDAMTAARDDDVEFYVDRATAADGPVLELAVGSGRIYLDVLESGVDADGVDVSPEMLDVLRDRAAARGLDATVWEGDMTDLAGTTDRAIEGRYDLVYCPFNALQHARSVDDQQAVFESVYDALVSGGRFVFDVFVPNFELIEATYGEWQPQTVDFRGSEHELRTRSQFVDEPRQIVEVENQLRDLDGEVVHETSHRISPLPYQQVELLARASPFDSWDVQGGFDGKALEDGDAVQVWTLEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H2</accession>
    <name>R4W8H2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446667.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09140"/>
    <dbReference type="EnsemblBacteria" id="AGN01773">
        <property type="protein sequence ID" value="AGN01773"/>
        <property type="gene ID" value="L593_09140"/>
    </dbReference>
    <dbReference type="GeneID" id="16182782"/>
    <dbReference type="KEGG" id="sali:L593_09140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1875"/>
    <dbReference type="eggNOG" id="arCOG01350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_2"/>
    <dbReference type="OrthoDB" id="78237at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="407" mass="41570" checksum="954FF822217EE1A0" modified="2013-07-24" version="1">MRLGLVVNPVAGMGGRVGLKGTDGKVEAARERGAEPRAPERAAEAMAAFAERAPDASVFAGPGEMGAAATKAAGFTPVVVGDVDPVATEAPASTTADDTRAVVTALVDRGVDLVLFVGGDGTAVDVAKALDAAEAVAGDAVSEPDESTPMLGVPAGVKVYSSVFAVTPREAGRIAAEYEHVEDREINDIDEDAYREGAVETELRAVRPVPVAEGVQASKQLGGGSVEGLVEGFLADLTPGTTYVFGPGSTVGAIEDALGIDGSPLGVDVWRAPEPFDRPPSADAPPEGELLVRDGSADEIRAATIGEAADSPDDEAAADDGTDAAAADVVVVVSPIGGQGFLFGRGNQQIAPDVIRAADLAVVGSRRKLDGVGVLRVDTDDPDLDESLRGWRKVRVGRVEHRLVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K1</accession>
    <name>R4W8K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446767.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09640"/>
    <dbReference type="EnsemblBacteria" id="AGN01873">
        <property type="protein sequence ID" value="AGN01873"/>
        <property type="gene ID" value="L593_09640"/>
    </dbReference>
    <dbReference type="GeneID" id="16182812"/>
    <dbReference type="KEGG" id="sali:L593_09640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1985"/>
    <dbReference type="eggNOG" id="arCOG04586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043026_1_0_2"/>
    <dbReference type="OrthoDB" id="34310at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="2">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="325" mass="37449" checksum="71B7F3BEB2DF8A4A" modified="2013-07-24" version="1">MPDSTSAVPQVDVDYDDGSGEDPENYPNLQAKIEKAIEVTREGLEQYDNPAVMWTGGKDSTLTLYFIKEVAEKFDLEVPPAVFIDHFQHFDEIHDFVDHWAEEWDLDVVYARNEDVGEYVEAEGLEPGDDIPIDALSEHNQHHVRNILEYEEDDFPFLLDTYVGNHLLKTVALNDALEEYDIDGVISGVRWDEQEARADETFFSARHDPDIYPPHDRIQPILQFDERAVWDAFWHYVVPDTVEGFPEEGHVPQDAEDLPEGIEWEDIPISPKYVMGFRSLGSEVSTEKTTEDPAWLQDLEDTTERAGRAQDKEDLMERLRDLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L5</accession>
    <name>R4W8L5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, BolA superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446812.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09865"/>
    <dbReference type="EnsemblBacteria" id="AGN01918">
        <property type="protein sequence ID" value="AGN01918"/>
        <property type="gene ID" value="L593_09865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182839"/>
    <dbReference type="KEGG" id="sali:L593_09865"/>
    <dbReference type="eggNOG" id="arCOG04647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_2_2"/>
    <dbReference type="OrthoDB" id="126486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8801" checksum="578C33A05305AAB0" modified="2013-07-24" version="1">MDPEEVAALIEDAIPDATATVGRPRGVDDDDHLAAEVVSPAFEGETVLDRHEMVYDALGEHMTTDIHAVELTTKTPEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M4</accession>
    <name>R4W8M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446832.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01938">
        <property type="protein sequence ID" value="AGN01938"/>
        <property type="gene ID" value="L593_09965"/>
    </dbReference>
    <dbReference type="GeneID" id="16180202"/>
    <dbReference type="KEGG" id="sali:L593_09965"/>
    <dbReference type="eggNOG" id="arCOG06292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088480_0_0_2"/>
    <dbReference type="OrthoDB" id="114302at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="29739" checksum="3554D0675D6C57A3" modified="2013-07-24" version="1">MSSTTGRRRVYGVDFSGAQDAGRNVWLASATRRADSLVVEGCYPGEALPNSGRERDACLPALREFLAGADDAIVGLDFPFALPAELIDSSTWPAFAAAFPNGAEGPTEWAEACRDRAETLDRDRVELKRATEDETGAPFSPYNLRMRSSTYYGISAVLAPLVDRDDASVLPMMPPNPGTTWLVEACPAVTLDRLDLESEGYKDDDEAAEERRAEIVDALATGPATVAPAVRDAAIEEPDGDALDAVLAAVGVTMAVDRGEPTSPGTVDARTRIEGKIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N2</accession>
    <name>R4W8N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445658.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04065"/>
    <dbReference type="EnsemblBacteria" id="AGN00764">
        <property type="protein sequence ID" value="AGN00764"/>
        <property type="gene ID" value="L593_04065"/>
    </dbReference>
    <dbReference type="GeneID" id="16180119"/>
    <dbReference type="KEGG" id="sali:L593_04065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.826"/>
    <dbReference type="eggNOG" id="arCOG01334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1237963_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23859" checksum="BCF818A75B3EB4DC" modified="2013-07-24" version="1">MLWLAIVVGLFAAGLSLVLLAYAPRLGYSLREPSETEAERIEQLLEDVGAPDVETAVRTTTRDGAIECDLLGLPGDRTLVVADAAFEGLEDESLRALVAVEVERARSRIEIPQALASGVAVAVVAAAYVTSLPVLPTFLVGWAIVLGGIALVRRQYYAADDAAGELVGRTVLCDAIERAARRRGASLETGRRWHALVDVEPSVGARIERLRTTPNPQPTEPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R4</accession>
    <name>R4W8R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446917.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10390"/>
    <dbReference type="EnsemblBacteria" id="AGN02023">
        <property type="protein sequence ID" value="AGN02023"/>
        <property type="gene ID" value="L593_10390"/>
    </dbReference>
    <dbReference type="GeneID" id="16182013"/>
    <dbReference type="KEGG" id="sali:L593_10390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2142"/>
    <dbReference type="eggNOG" id="arCOG03915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420125_0_0_2"/>
    <dbReference type="OrthoDB" id="109450at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10300" checksum="FC2970A2A5C636B4" modified="2013-07-24" version="1">MAAYTEVLEAVLMMLRLALFALALGLTIISFQAYRENGGKRLESAFIGFAFISMGVAMTSMGDQVESLELFFSIAETVPFIIGFGMLWISLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S5</accession>
    <name>R4W8S5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate mutase epsilon subunit</fullName>
            <ecNumber evidence="4">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase E chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glmE</name>
        <name evidence="5" type="ORF">L593_04675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate mutase GlmE subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445778.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04675"/>
    <dbReference type="EnsemblBacteria" id="AGN00884">
        <property type="protein sequence ID" value="AGN00884"/>
        <property type="gene ID" value="L593_04675"/>
    </dbReference>
    <dbReference type="GeneID" id="16181059"/>
    <dbReference type="KEGG" id="sali:L593_04675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.955"/>
    <dbReference type="eggNOG" id="arCOG06231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029922_0_0_2"/>
    <dbReference type="OrthoDB" id="12108at2157"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00245">
        <property type="entry name" value="Glm_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01923">
        <property type="entry name" value="Me_Asp_mutase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014714">
        <property type="entry name" value="Glu_mut_E_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01503">
        <property type="entry name" value="MthylAspMut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="3 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamate binding" evidence="4">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
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        </ligand>
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        <location>
            <position position="96"/>
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        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        <location>
            <position position="119"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="167"/>
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        <ligand>
            <name>L-glutamate</name>
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        </ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
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        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        <location>
            <position position="289"/>
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            <name>adenosylcob(III)alamin</name>
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        </ligand>
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        <ligand>
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            <position position="322"/>
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        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01923"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="477" mass="51697" checksum="6D5CC0AC5724208A" modified="2013-07-24" version="1">MVTDERLADAELRRIDEQVRSDWHTGADVDFEEAIEFHESLPDSKRFADVLESAETPLLQPRAGVPRLDDQIELLRHLQNEGGADLLPTTIDSYTRDNEYGKAGDGLEDARETAEDTLNGFPAVNHGVEGCRDLICALDAPIEVRHGTPDARLLAAVTYAGGFQSFEGGPISYNIPYTKERDLATTIEQWQYVDRLAGAYTERGVRINREPFGPLTGTLVPPCIAIAVMVVEGMLAATQGVRSITLGYGQVGNFVQDVAALHALRSLGEEYLPDPVRVTIVFHEWMGGFPPDEARANAVISLGAATAAIAEPDKVITKSPQEFAGVPTMEANAAGLRTTRQLIDMLLEQNVQLEGVDRELNLIQKASRELIEAAIDAGDGDVAQGTIQAFETGALDVPFAPSESAQGAVLPARDDDGRVRILEFGDLALSADVQEIHENRLEARASTEGRDRSFKMVADDVDAISDGRLIGRPTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T2</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="35"/>
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            <begin position="41"/>
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            <begin position="136"/>
            <end position="162"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="19274" checksum="E4B486DD618B7419" modified="2013-07-24" version="1">MPTPTNASARWLPRLGLFSAAFGILYLLVYVAWRYTDAPEAVVLIAPLVVVATLVWSGAGITWYCTACQRRVFGVHCRSCGRRQWTRTDLRYHLVLFVLLVPVGAGLVQFFLFGLLSPVLELLVERSYLTPPPASSLFVAPVGSVVYTIVTMPPAFLAAVGIDGLRAGLPWIVPAGD</sequence>
</entry>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="232"/>
            <end position="251"/>
        </location>
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            <begin position="252"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="272" mass="29416" checksum="4EC54F0F1BBE79C1" modified="2013-07-24" version="1">MGSVNPNRVDSIVDLVYGLLIAISVGLILVAGTSVGVAFGFGVLLSYVIHVGWKMARFDPDWMTTAVKETVEETVEETVEETVDKTVDEKVGETVEETVSETVEETVDQTVSQSVEETVEAKVGESVEPTVDDTVGETVEETVDKTVDEKVGETVEETVSETVEETVEQTVSDTVEETVEETVEEAVEAKVGETVSDTVEQTVSDTVEETVEETVEQTVNDTVEETVSDTVEETVEEKLEGELQSQAGDEQRDDEGESDAQDDEDAAGNESD</sequence>
</entry>
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    <accession>R4W8X4</accession>
    <name>R4W8X4_9EURY</name>
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        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_11090</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_11090"/>
    <dbReference type="eggNOG" id="arCOG00834">
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    </dbReference>
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    <dbReference type="OrthoDB" id="74004at2157"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="19894" checksum="E59BB047E98D7E04" modified="2013-07-24" version="1">MTTADARSPRSPAVARTFTDQRDRTIHLRQYERGLDPLEDFYEYFDDESRAQGIPPRSAPRRSAWIEDLLEGHNVVAWHEEPEDAPDATERIVGHAVLVPYGDAEAELAIFVRPDYQSAGIGTELVRSLLALGRSEGVERVTLVVEPSNTIAVSLYRTVGFSVTDKHRGEFQMAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W925</accession>
    <name>R4W925_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_05950</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446033.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05950"/>
    <dbReference type="EnsemblBacteria" id="AGN01139">
        <property type="protein sequence ID" value="AGN01139"/>
        <property type="gene ID" value="L593_05950"/>
    </dbReference>
    <dbReference type="GeneID" id="16182453"/>
    <dbReference type="KEGG" id="sali:L593_05950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1219"/>
    <dbReference type="eggNOG" id="arCOG04573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015959_0_0_2"/>
    <dbReference type="OrthoDB" id="86761at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="876" mass="90618" checksum="12697CD1528C08D7" modified="2013-07-24" version="1">MSTEGAPDDEITVSDNGITVEKEFSADDFPVPAIRFLIRSERSETVSVRLSESIPEEFPMDGVGFHPDYESDNWAAFQDHHVEYERELDPDEEIETVYAIRIDDPSEADPFLTPPEIAEVSPAGDAVSLEPGAGESIDGTTIDDIAPAEDDEAVKDMIAGEAEDGADAAADATADSPEGDDAAADPLADDATDPLADDATDPLAGDDAGEDLDLDLGDVDTEPEDLAADADDDPTDDVPDIDLGFDEADPAEGDAADADASDLDLGLDDDDLGAIDEEAPAETDAVEGEDADVTDEAAAEAVEPGEEAAEPEGAADDPDETTAESDDAEADDESAADAPEIEIDVDAAEEKVEGTGEDAEGEADEPAADEPDEAAAEAADADDESGPVDDEPILDLADAEDAAAEEPDADEGEADEGAADEDAADDADAIAVEEPADDVDATEVAAAESDDAPADEEADDEAEETAEEAGPEDDEETADEPASADDVEDETDESAPESGIEAAVDEAVAGAEAAEPAASAADEPDADEEADAEADAEAEEAAETEEAAGAKADAEEAVVEDDEVAEAADADGVDAADVAAEEADDAEAAEEEPAPEPVATGPAVEALDEHDSLAGALAAELESGDVPEEDREALEDALDVEAEDAGGAGGAAAGGAFEAKLNHLQGRVDDVAAYADAMEAFLDEEGTGQQLIEEFREEVEALDAEVSGFAEQIDAIEADVDDVEADVDAVEAEVDDAATDLDDLTDWVGDLDDDVSEVFAEVDNVADDVATVEEEVATIEDDLESTDAAVDAVESDVDAVETDVDSMETDVDELQATLDEVEAAVDDVEADLQDDVEDLRSRLDELSSVEDEVEDLAADVEDIKQWRSQLGEMFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W951</accession>
    <name>R4W951_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446083.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01189">
        <property type="protein sequence ID" value="AGN01189"/>
        <property type="gene ID" value="L593_06200"/>
    </dbReference>
    <dbReference type="GeneID" id="16181657"/>
    <dbReference type="KEGG" id="sali:L593_06200"/>
    <dbReference type="HOGENOM" id="CLU_2893414_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6620" checksum="3D6F1A2DF9158BA4" modified="2013-07-24" version="1">MVTYGVVAVILPQIPAMIGRLGYALLTPGESISPEYPEIWLARVLGVVSLAFGTLTLYEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W959</accession>
    <name>R4W959_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06225"/>
    <dbReference type="EnsemblBacteria" id="AGN01194">
        <property type="protein sequence ID" value="AGN01194"/>
        <property type="gene ID" value="L593_06225"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1272"/>
    <dbReference type="eggNOG" id="arCOG03779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122659_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="28432" checksum="8BAE2A1650F0FAE9" modified="2013-07-24" version="1">MNYHTELGAVSDGVKRARDFDISYAVILDEITRADISQIFGPLYTAIENRNQTLIETDDGEPIELDEDVSIICTMNMSDRTVNELDNAITRRFAMVELDEYEDDDRESLFTGWIEEELGDIPLVDSGDLLDLFEADYQGINHGSEQASRGRIMRFGPMHYRDVTVFLREALQDEELYMDEPEEAVGQAFQTFIVPRLLNSAAFPQIEQIEQHYRYLDKEFDDFDLSPAVELAGRELEAEQRQMGSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W979</accession>
    <name>R4W979_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar ABC transporter periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446138.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06485"/>
    <dbReference type="EnsemblBacteria" id="AGN01244">
        <property type="protein sequence ID" value="AGN01244"/>
        <property type="gene ID" value="L593_06485"/>
    </dbReference>
    <dbReference type="GeneID" id="16181765"/>
    <dbReference type="KEGG" id="sali:L593_06485"/>
    <dbReference type="eggNOG" id="arCOG00258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="50"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="367" mass="38157" checksum="16B7742B079F3613" modified="2013-07-24" version="1">MRDSTDIRRRSFIKAAGGGVALTGLAGCLDRLPGGGGGSDDFSAAIISGPGGFGDNAYNDSALQGLEQAAEENDGSVNQVQGAGGEYRSLQSQLAESSDDYDVIVCVGFYQAEALKQSADEYSDQNWMLINQGLYRESGDHYENVAGYVWGNHEMSYLAGVVAGTMTTRELTYEGNSNDPSGSTVGFVGGVDSALINAFEEAYVAGAQWADSNVDVTVGYAGSFQDPAAGREVALSQYEAGADIVYHAAAGTGPGIFQAAQEESRFAIGVDGEQSLALPDYSDVIVGSAVKDINVGTYDVSTAAYNGNWGDVSGFKTYGLEQEAVRFNKGADVGGELPSVVDENLQEATEGIVNGDITVPCSATGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B7</accession>
    <name>R4W9B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12995"/>
    <dbReference type="EnsemblBacteria" id="AGN02538">
        <property type="protein sequence ID" value="AGN02538"/>
        <property type="gene ID" value="L593_12995"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12995"/>
    <dbReference type="eggNOG" id="ENOG502N663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292156_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1043" mass="105942" checksum="998354B2F7DBEF2D" modified="2013-07-24" version="1">MICLLAVLGALGAAPAGATVPHDGGASSPAAEFDLGAAASALSAQQDSSEQAGGNGSIGSAARNGSTLTLSTSVNRTGDLGNETTFAVSVPAANGSATVEASRSGDRYAARVPVPEVVGRNATANLSAATVVASRGGTVVVEDAADLRWIEQTGPATFRASSLAIPADVRGIGDAPPTLVGEANGSRFPATVAGVGPNATLLLSPGTLAGVPANQSITADAVLANATVTAAPLQFTIGDAAGRATAIAYRDADPVVVQPLAHPSIGPDRIALTLTTGDPNGRYHVRIADRSGVVPVPASVVGAGSIHVRVDEPNGTTLLQTPVSAPARPTVQLRIANGSLHAPNPAAIEPYDGLLLRDGNVSYVPLDDSLAAGEEQPLPRMLSEPSTDAAALLVGEGVRPARVDLTVVPPPTGSSPDPVPEDPDEDAFVSLWLDVGAIVGLLFLAMVGSVLAVASVYGLRRLSPARAAAAGPRAVLGHFLFGGIGGAACIAVLQSRYGGPILGSVDIAGAVVGLGALLVGVFHGGLTATGIRLGLGTIGAWPTRRVIDETAVPVRIRFTDDEDGELPGEQTVEVAQATDGTIVETTRLAGTTTEVELPPGEYVVQGLTAERESEAVDLAVEQPTTPTPDPIPVHLTVGRPGLQVEVTDAQTGDAVPEGQVTVTTDREETKQADVEAGSVTTTLPIATGSVSVVVGAPGYDDATVEVPIEESLTTVDVALDPSSGTLVVSALVAGAPIADATVQIEPAVEDDEESKSDDAADPDSATSTESVATGTPPEIGVRTAEVETDEDGQASIDLPAGRYRCHLALDGPNADLFAVQDGQATVEPDAETSVAVYARFDWEPVEHVQRRAAGLQNTIQSVAEEATADPTIPLYFAGVTEALMECVATLPDAGQHFATSTQDPDEVAEVTVAAAEAALEAVGQAMQEEAVREVITASSEPVRISPRLDADPGALLAYLEQDLTVASVESRAHEVEASLDRAAERLRSVAPASAVVQKAVSLVPADDSTTRGAAMEFAALLLLDAAEQSLARSAIRSRFDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F7</accession>
    <name>R4W9F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01469">
        <property type="protein sequence ID" value="AGN01469"/>
        <property type="gene ID" value="L593_07620"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07620"/>
    <dbReference type="eggNOG" id="arCOG06230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217071_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="37" mass="3859" checksum="B39C8B55FBBC53D8" modified="2013-07-24" version="1">MAAYLAEHPRMVGALFTILLLLSQVGSVAANQNSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I2</accession>
    <name>R4W9I2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfc</name>
        <name evidence="6" type="synonym">rfcS</name>
        <name evidence="8" type="ORF">L593_07970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN01539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07970"/>
    <dbReference type="EnsemblBacteria" id="AGN01539">
        <property type="protein sequence ID" value="AGN01539"/>
        <property type="gene ID" value="L593_07970"/>
    </dbReference>
    <dbReference type="GeneID" id="16182271"/>
    <dbReference type="KEGG" id="sali:L593_07970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1634"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_2"/>
    <dbReference type="OrthoDB" id="37207at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="54"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="37403" checksum="0250A98A96D057A4" modified="2013-07-24" version="1">MSEADADAVDDAADDQVASRDDVWVEKYRPQRLEDVVGHETITERIQQYVAGDDLPNLLFAGPAGVGKTTTAVAIAKEIYGDDWREHFLELNASDQRGIDVVRGRIKDFARTSFSGDSYGFRIIFLDEADALTSDAQSALRRTMEQFSNNTRFILSCNYSSRIIDPIQSRCAVFRFPPLSDEAIREQIEIVAAEEDITVEDSGYDAIAYAADGDMRRAINALQAAAATGQTVVDEEAVYEITSTARPEEVLEMVEHAIDGDFLAARADLESLLIDRGIAGGDVIDQLHRSVWDLELEEQATVRLMDRIGEAEYRIVEGADERIQLEAMLAGLALEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P8</accession>
    <name>R4W9P8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome d ubiquinol oxidase, subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_08695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08695"/>
    <dbReference type="EnsemblBacteria" id="AGN01684">
        <property type="protein sequence ID" value="AGN01684"/>
        <property type="gene ID" value="L593_08695"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1782"/>
    <dbReference type="eggNOG" id="arCOG04791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="37803" checksum="D7BC0BFAFE8E5040" modified="2013-07-24" version="1">MSGAVGTEAASGALRGVAEASALDGSAAASPTPLLVPDEYLFDGLPEFWFALVLGTLAAYVALDGFDFGVGMWYATRDDEHDREQFLAAFGPVWDANEVWLVAFGTTLLGAFPAAYAALLSEHYLLALGAVAALLFRGVAPELREQREDQRWRRACDRLFVAGSTLSPLLLGTLVGSWVFGTGTLSLPAILTGVGLIALSLTTGAAYLAVKTAAPLRDELTRYGQFATAGYLAGVVVLLAVLFALDPRGITTDLLSAPVLAIVLGSVGLGVGGVALARRERHREWFASTLGLAVLLGLLVAVLLYPEVYPATGLTVTDAAVSPIALNLMTILGLPVLVLVGGYFVYLYSVFGGTVESEGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T0</accession>
    <name>R4W9T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446643.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09020"/>
    <dbReference type="EnsemblBacteria" id="AGN01749">
        <property type="protein sequence ID" value="AGN01749"/>
        <property type="gene ID" value="L593_09020"/>
    </dbReference>
    <dbReference type="GeneID" id="16182600"/>
    <dbReference type="KEGG" id="sali:L593_09020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1850"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_2"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="14744" checksum="DD61F9A1AA8D1687" modified="2013-07-24" version="1">MSDDCIFCAIVDGEIPGEIVYEDEDVLAFLDANPLARGHTLVIPKAHHETVSDLPGDLGAAIGRVASDLAPAIESAVDADGSTVAFNNGEAAGQEVPHVHCHVVPRFESDGHGPIHALFGSRPDLDDEEIASVGDAIRDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA07</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="arCOG09000">
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="9805" checksum="E62B625FD6E0BF6B" modified="2013-07-24" version="1">MDNYTDTADLVGMLGGALVAIGVVVLGALNTLTQNPHMEQTNDAGAVTAEPLVPADIRAYIILIGLALLLLYGLYKVATPLEPTTVQRTAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA62</accession>
    <name>R4WA62_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Restriction endonuclease</fullName>
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        <name evidence="3" type="ORF">L593_12290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02399">
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    </dbReference>
    <dbReference type="GeneID" id="16179844"/>
    <dbReference type="KEGG" id="sali:L593_12290"/>
    <dbReference type="eggNOG" id="arCOG02777">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606365_0_0_2"/>
    <dbReference type="OrthoDB" id="58586at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="467" mass="51564" checksum="B9DB646A283ED4B7" modified="2013-07-24" version="1">MTLLDELSGFEFEEVMVEVFRHQSYSDVEQAELIADEGRDVTMVDDRDVAAGEEPTAVVVECKHTDVVSRPVVQKTHSAVHTYDYDGPIRAMIATTGRFTAPAREYAEHVAVDPDDVDFELLDGAALRELSEEIPIDLYNGKIEIVCDEAIAPPTDRETLEGYLEAAAADVHNLDEWTVGATLTAVRFEPVLVAETVVDANFETDVGVIHEVEECERSILDGHAVEPARHSDSVAEFVETAEPSRIALDDHALDGTFDRTDIERFEHDERSYREWLVADLADRHETTVSYTGDNGIEYERTCRPGDADVDVETLDPVYLPHVAVATSLGEYEYELELYAAGGKMLVRDAEFERCVHCEAGRKDAGPGASVDQREARSLTYCANCGAIACPDHTETERLVGEPVCTGCAVTGRFAGATRYFYDVTNRETFADAYAEMPLHRKVRENEALVAVLALVTFLLCVSAIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA66</accession>
    <name>R4WA66_9EURY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12400"/>
    <dbReference type="EnsemblBacteria" id="AGN02419">
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    </dbReference>
    <dbReference type="GeneID" id="16179923"/>
    <dbReference type="KEGG" id="sali:L593_12400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2550"/>
    <dbReference type="eggNOG" id="arCOG04570">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090976_1_0_2"/>
    <dbReference type="OrthoDB" id="90597at2157"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="179" mass="20625" checksum="5BB45714A6E4A623" modified="2013-07-24" version="1">MATDWKAELRSERAAKDEYFGSNPHSPIPAPEREGFDGLSYYPPEESLRYELELHEYDDPDEVVVGTSTGGEQRYLEWGEFRFAVDGEDVTLQAYKSDPDQDRLWVPFRDETSGEATYGAGRYLDLEPDEHLLESGRWVLDFNEAYNPTCAYSDHYECPLPPTENWLEVPIEAGEQSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA70</accession>
    <name>R4WA70_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12500"/>
    <dbReference type="EnsemblBacteria" id="AGN02439">
        <property type="protein sequence ID" value="AGN02439"/>
        <property type="gene ID" value="L593_12500"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12500"/>
    <dbReference type="eggNOG" id="arCOG08095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597907_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="9174" checksum="A518809C8CE1D8A5" modified="2013-07-24" version="1">MKESLQEEIEENTELPEDADLSEEVKKFVRRERNKVYNPGISTEEVATEFGISMETAHDALDESPHLDSKEVGDQHIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA8</accession>
    <name>R4WAA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447523.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13450"/>
    <dbReference type="EnsemblBacteria" id="AGN02629">
        <property type="protein sequence ID" value="AGN02629"/>
        <property type="gene ID" value="L593_13450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180634"/>
    <dbReference type="KEGG" id="sali:L593_13450"/>
    <dbReference type="eggNOG" id="arCOG11390">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284984_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="10765" checksum="3B3E2DDC65D7F29E" modified="2013-07-24" version="1">MGDRNLTLFAFHSHGDVQFGPTSIPAPGSKDESEAESAGKSWFGGGSSKEESEDESIDVPAEDESGGLGGLVVALVVLVGIAMVVKKLKGGDEGTEVEVAESDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE0</accession>
    <name>R4WAE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447683.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14250"/>
    <dbReference type="EnsemblBacteria" id="AGN02789">
        <property type="protein sequence ID" value="AGN02789"/>
        <property type="gene ID" value="L593_14250"/>
    </dbReference>
    <dbReference type="GeneID" id="16181007"/>
    <dbReference type="KEGG" id="sali:L593_14250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2917"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_2"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="180"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="39823" checksum="77E388D017C97E83" modified="2013-07-24" version="1">MDELRALARDLVATPSHDDPDAAGDLIEDWLREETTATVERDAVGNVLAWHPAGDDHLADGDGSLALVGHHDVVPPDDEQVTDDGEYVVEERDGRLYGRGSADMKGAVAAAMLAFRDAEEAQPEPDGNARPTIQFASFVGEEIGGEGARHAIDEGFAPDLAIVGEGSTGYSGPGVTDVAIAHKGRRASTIVAHGESVHASAHEEGTNAIYRACDAVSTLRDLSVPEVEVAGEALSGSIVATEIEGGSAWNVVPDRCTVTVDERTVPGERAALDELATADGIEWVVEQDLPPMRCEDSAFADLVLDAARSNVDDAAAGTAQHVVKPHATDAGWLSEAGTDCVICGPAESGEAHTATESVSIAVLDRCRSIYRDALEAHLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG8</accession>
    <name>R4WAG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_14975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14975"/>
    <dbReference type="EnsemblBacteria" id="AGN02929">
        <property type="protein sequence ID" value="AGN02929"/>
        <property type="gene ID" value="L593_14975"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14975"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="337" mass="36031" checksum="0052283E954A0115" modified="2013-07-24" version="1">MDRTRGSNVDGGNRRAMSGATAPVIEVEDLQKRYGDLTAVDDVSFAIQADEVFALVGPNGAGKTTIVEILECLRTPTAGTATVLGHDVRSDTQAIKDAIGVVPQSFHTFDRLSVRENVALTRRMYDDGRDVDDVLDELDLDDYADTRFESLSGGYQRRTGIAMALVSDPEVLFLDEPTTGLDPAARRSTWRQIESLAAAGTTVVLTTHYMEEVEELADRAALLLDGTIEAVDTVQNLIATYGGDVKLVVGAGAGEDAAIESILESTATEVYRNETDDFVALYEDRAVAQTAFGDVLDVNGERSIDLTTAGMDDVFLRLAGAPVEVVGDGTATGGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAH0</accession>
    <name>R4WAH0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphatase</fullName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_15025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15025"/>
    <dbReference type="EnsemblBacteria" id="AGN02939">
        <property type="protein sequence ID" value="AGN02939"/>
        <property type="gene ID" value="L593_15025"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_15025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3069"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="270" mass="28502" checksum="5D543592F13E1FC1" modified="2013-07-24" version="1">MDVTSDPAERLAVAREAATAGGERALQDFRGDVAVETKSGPTDYVTEADRAAQRTVVETIRDSFPDDPIVGEEDETPNSVPESGPAWVIDPIDGTANYVRGMHCWTTAVAAVEDGEPVAAVIAAPALGDLYAAGEDGATRNGDRISVASRSDPQEAAVCPTLWWSRDRREEFGAVADAVVRSFGDCRRIGSAQYELALVADGALDATIANVFASPWDTIAGAHVVRQAGGRVTDVEGERWRHDARGIVASSGEIHDEALEATQAGDGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSU1</accession>
    <name>R4VSU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445144.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01485"/>
    <dbReference type="EnsemblBacteria" id="AGN00250">
        <property type="protein sequence ID" value="AGN00250"/>
        <property type="gene ID" value="L593_01485"/>
    </dbReference>
    <dbReference type="GeneID" id="16179827"/>
    <dbReference type="KEGG" id="sali:L593_01485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.302"/>
    <dbReference type="eggNOG" id="arCOG04608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773249_0_0_2"/>
    <dbReference type="OrthoDB" id="91696at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043814">
        <property type="entry name" value="DUF5796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19109">
        <property type="entry name" value="DUF5796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="17218" checksum="CEB8BAB8B09E7FBD" modified="2013-07-24" version="1">MSHRSTVSPATLPVELREEGVVVEYLDEREAFYRGVPQKREGSVRTRPGVLVQVLVTDPTDSEGVLTYVNDRSTHDDILEETGVGRVFVEPGEETELFPGVTARADGHAIVIEGEPEVARGRIFVFAEDEMAEQSYEIVSPEEDESTEEPGDATEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSY7</accession>
    <name>R4VSY7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="9" type="ORF">L593_01770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445199.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01770"/>
    <dbReference type="EnsemblBacteria" id="AGN00305">
        <property type="protein sequence ID" value="AGN00305"/>
        <property type="gene ID" value="L593_01770"/>
    </dbReference>
    <dbReference type="GeneID" id="16179938"/>
    <dbReference type="KEGG" id="sali:L593_01770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.359"/>
    <dbReference type="eggNOG" id="arCOG04101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_1_2"/>
    <dbReference type="OrthoDB" id="93236at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="233" mass="26152" checksum="DADACFD9642D3F69" modified="2013-07-24" version="1">MAKDVKPTRKNLMEIEDRIELSERGHDTLEKKRDGLIMEFKEILDQAQSVRENVEADYEQAQQTIDMARAMEGDVAVRGAASALKDHPEITTEAKNIMGVVVPQIESSSVQKSLDQRGYGVLGTSARIDETAAAYEELIESIILAAEVETAMKKMLDEIEKTKRRVNALEFKLLPELHENKEYIEQKLEEQEREEIFRMKKIKAKKEAAEKAEAAAEEAASETEEAVAAGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTB5</accession>
    <name>R4VTB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445349.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02520"/>
    <dbReference type="EnsemblBacteria" id="AGN00455">
        <property type="protein sequence ID" value="AGN00455"/>
        <property type="gene ID" value="L593_02520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180242"/>
    <dbReference type="KEGG" id="sali:L593_02520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.511"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_2"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="25482" checksum="54989159FFF88C99" modified="2013-07-24" version="1">MAKQPHLLVDDGDLTDIALVPGDPDRVERITEHCSDVEWVASNREYTIANATYEGRELTICSTGIGSPSAAIAAEELAAVGVETLLRVGTTGALQSGIEIGDMVVATGAAKDEGTTKRYEDATVPAVPTYEVLSTLVDVAEAEDEAVHVGPIATDDAFYAETEAYVEAWEAAGLLAVEMEAAALFTLARRHGMQAGAICTVDGNLVEDTQKGETDDEELPPKARDNVERAIHLALEAATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTE4</accession>
    <name>R4VTE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445379.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02670"/>
    <dbReference type="EnsemblBacteria" id="AGN00485">
        <property type="protein sequence ID" value="AGN00485"/>
        <property type="gene ID" value="L593_02670"/>
    </dbReference>
    <dbReference type="GeneID" id="16180297"/>
    <dbReference type="KEGG" id="sali:L593_02670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.541"/>
    <dbReference type="eggNOG" id="arCOG01864">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_2"/>
    <dbReference type="OrthoDB" id="122167at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="7452" checksum="3A773A54AA12C571" modified="2013-07-24" version="1">MKNDLRARREAEDLSQEELAVAVDVTRQTINAIERERYDPSLELAFSLADYFGCSIEDVFEPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTG3</accession>
    <name>R4VTG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_02795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445404.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02795"/>
    <dbReference type="EnsemblBacteria" id="AGN00510">
        <property type="protein sequence ID" value="AGN00510"/>
        <property type="gene ID" value="L593_02795"/>
    </dbReference>
    <dbReference type="GeneID" id="16180302"/>
    <dbReference type="KEGG" id="sali:L593_02795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.565"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="42579" checksum="D9F443327D8C755F" modified="2013-07-24" version="1">MLDYLDLEADLTSEERLIRDTAREFVEDRVRPDVGDWYEAGEFPEHLIGTMGDLDFFAPNLEWGDLPGIGARAYGLLMQELEAGDSGIRSMASVQGALVMYPIATYGSDDQKERWLPDLASGDAVGCFGLTEPEHGSNPSAMETTAAPVDDGEGYVLSGTKIWITNAPIADVAVVWAKLSADTEHGDAGTVRGFVVDTARDGCTASEQEGKLSMRASATGELSLSGVEVPADAVLPGVSGMKGPLSCLTQARYGIAWGAVGATRDCFETAREYATDREQFGGPIARFQLQQSKLAEMATQHTTARQMAFRLAELKERGELRPQQVSMAKRHNVRVARDQARIAREMLGANGITTDYPPMRHAANMETVYTYEGTDDIHTLILGEDLTGIAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTH4</accession>
    <name>R4VTH4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">map</name>
        <name evidence="6" type="ORF">L593_02870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445419.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02870"/>
    <dbReference type="EnsemblBacteria" id="AGN00525">
        <property type="protein sequence ID" value="AGN00525"/>
        <property type="gene ID" value="L593_02870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180362"/>
    <dbReference type="KEGG" id="sali:L593_02870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.580"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OrthoDB" id="82853at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="12"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="32678" checksum="4241DF43234915CA" modified="2013-07-24" version="1">MTDVDFDAEQYEKHREAGEILAQAREETVEQIEVGATHTEIAEFAEERIRELGGEPAFPLNISIDHEAAHATATVDDDRTIGEELVNIDIGVHVDGWLADSAVTVDLTGEWDDLVAASAEALDAAIDEIEAGVQTGEVGAAIEAAIDEHGYNPVVNLTGHGLGHWEQHASPNIPNRAVSQGTTLEAGDVVAIEPFATDGRGKVSEGSHEEIFALEREGSVRNREARQALAQITEEWKTLPFATRWLDVNRPEMALRRLKQHDIVHGYPVLQEEEGTMVSQKEHTVIVTEDGCEVTTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU18</accession>
    <name>R4VU18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445589.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00695">
        <property type="protein sequence ID" value="AGN00695"/>
        <property type="gene ID" value="L593_03720"/>
    </dbReference>
    <dbReference type="GeneID" id="16180655"/>
    <dbReference type="KEGG" id="sali:L593_03720"/>
    <dbReference type="eggNOG" id="arCOG07553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2930355_0_0_2"/>
    <dbReference type="OrthoDB" id="144200at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="6860" checksum="96FCFF66E4FCCE58" modified="2013-07-24" version="1">MAVSSRNGTDRSFETSGVDAVSYDRYDQIRIDDGQVLIYDRDEEDGWLQSTLAVDLEVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU86</accession>
    <name>R4VU86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445654.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04045"/>
    <dbReference type="EnsemblBacteria" id="AGN00760">
        <property type="protein sequence ID" value="AGN00760"/>
        <property type="gene ID" value="L593_04045"/>
    </dbReference>
    <dbReference type="GeneID" id="16179936"/>
    <dbReference type="KEGG" id="sali:L593_04045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.822"/>
    <dbReference type="eggNOG" id="arCOG01794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102820_0_0_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="235" mass="26418" checksum="FBEF9E62E0654F27" modified="2013-07-24" version="1">MKGQEWYQEHDVAEAYEDKRFSGGGRLIDRREKEAVLDALGPVEDKRVLEIACGTGRFTVMLAERGADVVGLDISNAMLAQGREKARAAGVQDSLDFLRGDAGRLPFPDDHFDAVLAMRFFHLADTPEAFLSEMERVTKDLVVFDTFRRFSTRSIYNWALPMGSRLYSRSEVDGLLESADLELRQAWHDWVFPYGFYRQLPGAVARPFRILDGTLGSLPGGNALASVSYWQTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUP6</accession>
    <name>R4VUP6_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Translation initiation factor IF-2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN00950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00950">
        <property type="protein sequence ID" value="AGN00950"/>
        <property type="gene ID" value="L593_05005"/>
    </dbReference>
    <dbReference type="GeneID" id="16181176"/>
    <dbReference type="KEGG" id="sali:L593_05005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1020"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OrthoDB" id="84684at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="265" mass="29312" checksum="2525FEB28586B17E" modified="2013-07-24" version="1">MKYSGWPEPGELVVGEIDEIEDFGVFVDLKEYEDKRGLVHISEVASGWIKNVRDHVQEGQTVVAKVLDVDESSQQIDLSIKDVNDHQRSDTIQEWKNEQKADNWMEIAFPDGDDEDLTAIANALLAEYGTLYAAFEESAIHGHEALDGVDLEDDEIDAIVEAARDNVSVPYVTVTGYVDLESPGTNGVDDVKEALQAAEGNGEVPDEVDLEVTYVGSPEYRLRVKAPNYKTAERELEESGARAVEAIEGIGGAGEFHRDRRTEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUW7</accession>
    <name>R4VUW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate binding family 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444955.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00530"/>
    <dbReference type="EnsemblBacteria" id="AGN00061">
        <property type="protein sequence ID" value="AGN00061"/>
        <property type="gene ID" value="L593_00530"/>
    </dbReference>
    <dbReference type="GeneID" id="16181807"/>
    <dbReference type="KEGG" id="sali:L593_00530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.108"/>
    <dbReference type="eggNOG" id="arCOG02498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482042_0_0_2"/>
    <dbReference type="OrthoDB" id="67963at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="280"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="565" mass="57110" checksum="86A17F7A3EAE52E5" modified="2013-07-24" version="1">MDGSPPSERNPRLVIWVRIAVAIGFLLAFFGIVGYSVLGVGFAAKPLAADSSGVDSPRTDVNGSSDAGAGVAGPGNGTQDGDENESNTPIGENTTDDDSGADEGEADNSSNQTSPSEEMESTAGDGGDDLPGTSTDEETESDDAEDSGDDDTGAAGTESGDEQGVDGGASQGTGTDDGGNGAPPADSTPEPDDPTPEDGSGVRPVTECTVIDQPGTYEIGQNIGDTNVQEIDVGNGFVRPVCIAIQTSDVVLEGNGNVLGGSGESLSVGVHVYDPAGSTVSNVSIRNLRVEGWSNGVQIGVDTYVVASGASATASIEDVQTVDSENHGVFVVGPGSSLEGVTASGNDGSGIGLFDASGVRIDDATVSDNGDHGLALFEGVFDGEYTGITAANNGGSGIFIGTDSSGNRFADLSIRNNDGPAIRGYDGSDNEVDDPIVESDGGTERQPPEAGSNDSAGTDDADESTSGPSDANSTVGTDEQGEDETEAGERDETQREEDGDDDTEVEEDAEDDDADGDDADDDDGDESTTDTEEDEAGEGDTEDADDESTDDVTDDVVDLFTTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ7</accession>
    <name>R4VUZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444995.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00730"/>
    <dbReference type="EnsemblBacteria" id="AGN00101">
        <property type="protein sequence ID" value="AGN00101"/>
        <property type="gene ID" value="L593_00730"/>
    </dbReference>
    <dbReference type="GeneID" id="58789321"/>
    <dbReference type="KEGG" id="sali:L593_00730"/>
    <dbReference type="eggNOG" id="arCOG02782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838421_0_0_2"/>
    <dbReference type="OrthoDB" id="83873at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="35418" checksum="BB908B86B5762F5C" modified="2013-07-24" version="1">MGSPTARTIERHLLALDHDAFVEFVAALWTGSNWSVERGGPVLEIGRPGEQRRLLVLPPRRTFPGAWSAPAVEDADSIDAVVSPYRTAERSRLPRNLPVADVVTADGIRDRLLYALDESTRDRLLADHLGLDVEGSDATGLRPLPPVRIPDAGRVTAAGVGVFLLLTGIAVLVAATGVFPGGSSTTTVNASGPTSAGAYASADSPVYQSTPTCTRSPREVVEVTTAAVRGPRLGAGLVVMGRFWNPTLVEGVPTGVWDEMMRSDARMEYYNSSSVRFDDAVVLGDDAVVRATAVLYDGTERVYEFSLSRRDSSPHEGCWVIDGFAPVEDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVG3</accession>
    <name>R4VVG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446089.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06230"/>
    <dbReference type="EnsemblBacteria" id="AGN01195">
        <property type="protein sequence ID" value="AGN01195"/>
        <property type="gene ID" value="L593_06230"/>
    </dbReference>
    <dbReference type="GeneID" id="16181669"/>
    <dbReference type="KEGG" id="sali:L593_06230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1273"/>
    <dbReference type="eggNOG" id="arCOG05102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465129_0_0_2"/>
    <dbReference type="OrthoDB" id="59102at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="591" mass="67360" checksum="3D94937710C144D1" modified="2013-07-24" version="1">MSASDPDVTYQYEPGTFSVPERGSARIEGCPPSIGEQLRRASFEQEAANVFVKSQASLDDSDEEYRVVRVRIDGPTAHIDVRDNVGIISFTPRSKLRIEPKIDWDHIFDMLLAVHGRKRSVEYHGIPLSDVQSEDVDLEDVFLILAINYLDALEAVHRNGFVRELVTRRADLDQPRGVIDIEQSLVNQAEGRAQQNCLLKEVEYDNAANSLLLYAGKHLLRLFREYEEKYSQGMYYTIFSKVHQEVRNLESLDVTCDRRRIPEYRNFSLHDLPKQRHYYEQAVDVSKAITASSLGTPSVEGGWELTVDYVLNMESLFEQYSQVAIEEELEAVRESDRLGHTKNVSAVRSPTLKPFEDEGQIYHQPDHAVEEGEDTLAVLDSKYYSEDKDPVKSGGSRSRLFSYAYLLDTRHMGFLTPLNESMVRTVKQTGAELQVISPSGSGFSLEAYHKSVREYLQHVLEGTYPTLSVFRAVEDHALCLEQHDAEDLDRVVEAGGPFDFSNVPEFSLRVVNAAADTLSNRHRSRSDLEQQGKWTRRRIETQCNAREAESTTCVPVFRREDGEEHIYLYFIERDENDVPTAVTVEGGFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVG8</accession>
    <name>R4VVG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445130.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01415"/>
    <dbReference type="EnsemblBacteria" id="AGN00236">
        <property type="protein sequence ID" value="AGN00236"/>
        <property type="gene ID" value="L593_01415"/>
    </dbReference>
    <dbReference type="GeneID" id="16182696"/>
    <dbReference type="KEGG" id="sali:L593_01415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.288"/>
    <dbReference type="eggNOG" id="arCOG00060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_2"/>
    <dbReference type="OrthoDB" id="55005at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="41038" checksum="83D0C3E1B1B423E7" modified="2013-07-24" version="1">MERFETRSIHAGQAPDDETGAVMPAIQLSTTFEQDAPGEDKGYEYARTGNPTRAALEANLASLEGGEFGRAFASGMAAIDAILHTLEAGDRVVAGNDVYGGTHRLLTQVYDRHDLETKFVDVTDLDALEAAMTPDTELLWLESPTNPLLSVVAIEAAAEIADEYDALCAVDNTFATPYLQRPLDHGADLVCHSLTKYLGGHSDVVGGAIVTDDEGLDDQFGFVQNAAGGTPGPFESFLVLRGTKTLPVRMDRHCENAAQLASWLENHDAADQVYYPGLDSHPGHEIAAEQMDDFGGMVSVEFDASLDETSELVAATEVFTLAESLGGVESLIEQPAAMTHAAIPREERIEAGLRDGLVRLSVGLEHVEDLQADLQQAIEAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWC6</accession>
    <name>R4VWC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445475.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00581">
        <property type="protein sequence ID" value="AGN00581"/>
        <property type="gene ID" value="L593_03150"/>
    </dbReference>
    <dbReference type="GeneID" id="16180447"/>
    <dbReference type="KEGG" id="sali:L593_03150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.637"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OrthoDB" id="52466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="473" mass="49450" checksum="C8A6BF042FC5D689" modified="2013-07-24" version="1">MPGDPRRNLTEGSLARPLFHLAWPIVTIQLLQVTYNLADTVFLGWYDPTAVAAISLGFPILFLLLSVAGGFTTAAAILVAQYTGAEGSEDAGRIAGQAIAFVGLLSIGLGILGVLVTDPLLGALPADPDTGAEVLPLMSDYLTIVFLGTPFIFGFYVFTALMRGYGDTHTPMRIMAISVAINVVLDPIVIFGLGPAPELGIEGAAMASVFSRSLATVAGMYVLFRTNRGPDIALGDLRLELPTVREIVRIGTPTALEQSMVAVAMVLLTALVALFAPPVAAAYGVVNRLVSLVVLPAIGVGQATETVVGQNLGAEKPDRAERAVWLGSAVVGGTMLVVAIVAAAFPEPIVAAILGADSEHTAESIRLGSQYLRIRSIEFVFMGVLQVVLGGFRGAGNTKHALAVALLILWVARLPATYGLAIVLDWGSLGIWIGMSVGDVVGALVAVPWFMRGTWRESVVDAGLTDSPVAIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWL7</accession>
    <name>R4VWL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446529.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08450"/>
    <dbReference type="EnsemblBacteria" id="AGN01635">
        <property type="protein sequence ID" value="AGN01635"/>
        <property type="gene ID" value="L593_08450"/>
    </dbReference>
    <dbReference type="GeneID" id="16182419"/>
    <dbReference type="KEGG" id="sali:L593_08450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1731"/>
    <dbReference type="eggNOG" id="arCOG02292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108335_0_0_2"/>
    <dbReference type="OrthoDB" id="68989at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="24120" checksum="593B6406B3F4D493" modified="2013-07-24" version="1">MGYDAVVFDNDGVLVEPTDWDVIRAAIREAFNEVGVVEPADEHVERLIGVTVDDVHAVADAYDLDPHELWEARDTAGSRHQSELVRNGGKSLFPDVAALSRISRPMGVVSNNQHATVETIVDHYELEEHFDVVYGRQPTIEDVANKKPEPFYLNKALDEIGVEDAIYVGDSVKDIEVARRVGVDAAFVRRSHNDGVELPHEPELEVSDLERLADAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWW1</accession>
    <name>R4VWW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445635.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03950"/>
    <dbReference type="EnsemblBacteria" id="AGN00741">
        <property type="protein sequence ID" value="AGN00741"/>
        <property type="gene ID" value="L593_03950"/>
    </dbReference>
    <dbReference type="GeneID" id="16180735"/>
    <dbReference type="KEGG" id="sali:L593_03950"/>
    <dbReference type="eggNOG" id="arCOG04510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168011_1_0_2"/>
    <dbReference type="OrthoDB" id="127792at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="12169" checksum="BC9E1B9EBC95A1BC" modified="2013-07-24" version="1">MATAETPLPDEVGGHVPDDADLDVPDGAEIYRCPYCEYPLQTERLWILHVGVEHPEAMDPAQRERYEEEYDEESHDLFTLHVKLTVVIILLYFFLSYSYMFVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWZ3</accession>
    <name>R4VWZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446624.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08925"/>
    <dbReference type="EnsemblBacteria" id="AGN01730">
        <property type="protein sequence ID" value="AGN01730"/>
        <property type="gene ID" value="L593_08925"/>
    </dbReference>
    <dbReference type="GeneID" id="16182622"/>
    <dbReference type="KEGG" id="sali:L593_08925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1831"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23061" checksum="2A4DC3CAB5812547" modified="2013-07-24" version="1">MSETAVWFDLDGTLLQHERTFDAFVRDALVASGVVNPPEQAHDVFAERIFGALERCEDDPIERAFEAVDAQLGIDVDTAAAADAYREIEVDGTTLADGARETIDAAAERAAAVGVLSNGEGDLQRAKLDAHDLADAFDAVVISNEVGARKPDPEIFATAADRLSANGVDAAEHVFVADEYETDIGPAEQAGWSAIHVRNDEGPSGSVNRVGSLGTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWZ7</accession>
    <name>R4VWZ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_04175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445680.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04175"/>
    <dbReference type="EnsemblBacteria" id="AGN00786">
        <property type="protein sequence ID" value="AGN00786"/>
        <property type="gene ID" value="L593_04175"/>
    </dbReference>
    <dbReference type="GeneID" id="16181796"/>
    <dbReference type="KEGG" id="sali:L593_04175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.849"/>
    <dbReference type="eggNOG" id="arCOG00607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_1_2"/>
    <dbReference type="OrthoDB" id="51079at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="254"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="318"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="391" mass="41643" checksum="A29A236A8BF7E642" modified="2013-07-24" version="1">MPSFRIGSAFGVPVKLDLTFLLVLPLFAYIIGSRIESTAELFNDVLGAGLSVNALTGGATPWLIGVVAAVGLFACVLAHEFGHSLVAMHYGFPIDSITLWIFGGIASLSELPEDWKQELQIAIAGPAVSVAIGIGAYALSTVVPAGNDQVTYVLLYLGVLNVALAVFNLLPAFPMDGGRVLRALLGRTRSFAEATRIAANVGKWLAILMGLLGLFRLDIILVGIAFFVYIAAAGEAQQVITKAAFEGVQVQDVMTPVDRLHVVSPDVSVTELLQRMVRERHTGYPVIENGEPVGVVTLGDAREVREVERDAYEVREIMSTDLVTIAPDGEAMTALTRMQEHGVGRLLVVDDGMLVGLLSRSDLMAALDVLREGGELAESATAGRPPVDRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX54</accession>
    <name>R4VX54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446699.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09300"/>
    <dbReference type="EnsemblBacteria" id="AGN01805">
        <property type="protein sequence ID" value="AGN01805"/>
        <property type="gene ID" value="L593_09300"/>
    </dbReference>
    <dbReference type="GeneID" id="16182638"/>
    <dbReference type="KEGG" id="sali:L593_09300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1910"/>
    <dbReference type="eggNOG" id="arCOG02942">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375506_0_0_2"/>
    <dbReference type="OrthoDB" id="81085at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="21485" checksum="BF5FD5A638CC6A92" modified="2013-07-24" version="1">MPVLECDVERARARLAEAGATVESGNTEHERWRATLGEATAVAYDDKVVIQGSRPSDVQAVLAEDEGGAAEVYFDGASRGNPGPAAIGYVIANDGGIVAEGGETIGSTTNNRAEYEALIRALEVTESYGFDDVDVYGDSELVLKQLRGEYDVNVPELRERRVRAMELLESFDEWVLQHVPRELNDRADALANEALDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXC5</accession>
    <name>R4VXC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01890">
        <property type="protein sequence ID" value="AGN01890"/>
        <property type="gene ID" value="L593_09725"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2002"/>
    <dbReference type="eggNOG" id="arCOG08948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029630_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="312" mass="32495" checksum="70892D5E3BD46733" modified="2013-07-24" version="1">MTDPDTTHDRAECIATSVRDQFDDEGTSRRSFVTRSALAGGTLLALGGAAGMGLAQDDGDGETSGNETEDEVPAFENLDGTDLEVLNYALTLEQLERGFYERGLEQFTEEDFVNAESLQAQPEAVRQAVYAYVQRLGEQERIHANLLTEAVDLLGGTPAEPAAYDFGFETVDEMLVVGQTLENAGVAAYAGVAPLVESPDLLSAALAIHSVEARHAAIFNYLLGDSPFPDPFDPALSPDEVLEAVSGFYETVPAEVPGDVEGNLTDGMDGNVTGGNATGGTNGDGTNGNATDETGGNATTGNDTADSDTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXP7</accession>
    <name>R4VXP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446929.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10450"/>
    <dbReference type="EnsemblBacteria" id="AGN02035">
        <property type="protein sequence ID" value="AGN02035"/>
        <property type="gene ID" value="L593_10450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180317"/>
    <dbReference type="KEGG" id="sali:L593_10450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2154"/>
    <dbReference type="eggNOG" id="arCOG01814">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022751_0_0_2"/>
    <dbReference type="OrthoDB" id="4331at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="568" mass="57935" checksum="30BEF43DFC211B7B" modified="2013-07-24" version="1">MLTRTVRGLARLYPADVEASDDLARALSFLEAGVTPANVVRAGYGAGAVVACCVLPFAFLPPTAYRPIALVLGTGLALGVVHAVHRGPIALAALGRSRALGAAPDLIGRAILRMRVDPATESAVAFAADSGDGPLAASLRRHVRATAGAAGSGLDGFAAEWREWFPALARACHLLAAAGSAGAARRERALERSLEAVLEGTHERLQSFVTSMGGPITALYAFGVLLPLALVAVVPGARAAGLPVTLPVVVVIYDLVLPAILVGAAGWLLVRRPVAFPAPPIDRSHPDVPDRPWAGPLAGVAVGGIGAVLATILIGQWAGAIALCGIGGGVALVVYARPIVAVREEIRAIENGLPDALYLIGRRVDDGYSVERALELAAEQLPDATGDLLADAARRCRVLGVGPDVALRGEHGALATVPSRRVHSTAQLLTLATQEGTPAGQAIIAMAGHLEDLQSVEREARHSLARLTGTLRNTAAIFGPLVAGATVALADGMGAFGADTEAVGTMPTAGLGIAVGAYVLLLAVVLTTLATGIEHGLDRPLASYRVGLATTSATVVFLVGFLGAGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY41</accession>
    <name>R4VY41_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps14P</name>
        <name evidence="3" type="synonym">rps14</name>
        <name evidence="5" type="ORF">L593_11175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447074.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11175"/>
    <dbReference type="EnsemblBacteria" id="AGN02180">
        <property type="protein sequence ID" value="AGN02180"/>
        <property type="gene ID" value="L593_11175"/>
    </dbReference>
    <dbReference type="GeneID" id="16181378"/>
    <dbReference type="KEGG" id="sali:L593_11175"/>
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    <dbReference type="eggNOG" id="arCOG00782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_2_1_2"/>
    <dbReference type="OrthoDB" id="122051at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="7189" checksum="B8430E3EC78B1196" modified="2013-07-24" version="1">MSESEQDTSQDTGEHAEKRTGQLEACRRCGREQGLVGKYDIWLCRQCFREIARDMGFKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY88</accession>
    <name>R4VY88_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Glycosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02210">
        <property type="protein sequence ID" value="AGN02210"/>
        <property type="gene ID" value="L593_11325"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2336"/>
    <dbReference type="eggNOG" id="arCOG01410">
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="371" mass="40235" checksum="38F8F78B02955918" modified="2013-07-24" version="1">MTDPKRGVDSGFASAARDDPERDGGPGVDGDRPIADATETASQTSDARRRADGTATEQQADIRVLNLVTNHRARFFNQQVAALEDRGVECTTIAVPNDHQPGDGRSVLDYLRLLPPTIRESFGDYDFVHANNGLTAPAALLQPSLPVLVSLWGSDLFGRYGPITRRCAARADEVVVMSDEMADALPFEPTVIPHGVDLDRFAPQEQRAAREQVGWRTDCEHVLFPYDPGREVKDFPRAERLVAAAREQTDVEFELQTVSGVPHAEVATYMNAATVLVLPSKSEGSPNAVKEAMACNLPVVATDVGDVRERLDGVEPSAVSQDDEVLASAIAEIVERGERSNGRERVAAEVSVDATADRLYEVYRSIADAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYF0</accession>
    <name>R4VYF0_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Putative cupin</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_11710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447179.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11710"/>
    <dbReference type="EnsemblBacteria" id="AGN02285">
        <property type="protein sequence ID" value="AGN02285"/>
        <property type="gene ID" value="L593_11710"/>
    </dbReference>
    <dbReference type="GeneID" id="16181031"/>
    <dbReference type="KEGG" id="sali:L593_11710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2410"/>
    <dbReference type="eggNOG" id="arCOG03003">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156418_0_0_2"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="16577" checksum="178A060AE0D84153" modified="2013-07-24" version="1">MSDPEYLVGPDDVESQVFDWGVLKWLSTPAVTGGERFSAGIVKLEPGRGHERHTHPDSDEILYVVRGEGEQEVADETFDVEAGDLVFVPEGVEHGTVNTDWEPLLLLAVYAPPGPEEVLGDLPECEIVPPGEIPTTDRGRSDGGNDPAASEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYJ9</accession>
    <name>R4VYJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_06795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446200.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06795"/>
    <dbReference type="EnsemblBacteria" id="AGN01306">
        <property type="protein sequence ID" value="AGN01306"/>
        <property type="gene ID" value="L593_06795"/>
    </dbReference>
    <dbReference type="GeneID" id="16181881"/>
    <dbReference type="KEGG" id="sali:L593_06795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1388"/>
    <dbReference type="eggNOG" id="arCOG00216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="199"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="421" mass="44487" checksum="1C68AA5FD6621DAF" modified="2013-07-24" version="1">MTKDGTDATGDGADRRVAGFQTRTPLDEARKRLAEHVEPLADAEQLAIGRADGRVLATPVGSSRDVPHYRRAAMDGYALRSEDAAGASARSPAVLDAVEPDEREPSELPPGAARRVHTGSAIPDAADAVVPIERAAAIGSEIELTDPLAPGENVAPVGEDVSAGQALYEPGHRLRPSDLGLLKAAGIEAVSLRRQPTVGVVPTGVELVQHDPAPGQAVETNGLTVSRLVGRWGARAEYRNVVTDDPDALRAAIQRDLTKDVIVTTGGTSVGQRDLLPEVLDDLGEVLVHGVALQPGHPVCLGVVEETPVLCLPGYPVSCIVTAVQFLRPVLHWLTGTEPEQPPTKPATLTRKIESEPGTRTFARAELDAEDGRQVARPTRTKGAGVLSSVALADGWIEIEPDVEGLPEGDLVAVQDWEWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYV9</accession>
    <name>R4VYV9_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446325.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01431">
        <property type="protein sequence ID" value="AGN01431"/>
        <property type="gene ID" value="L593_07430"/>
    </dbReference>
    <dbReference type="GeneID" id="16182059"/>
    <dbReference type="KEGG" id="sali:L593_07430"/>
    <dbReference type="eggNOG" id="arCOG09032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143264_0_0_2"/>
    <dbReference type="OrthoDB" id="115895at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="13212" checksum="BC8E7E4A6D13191A" modified="2013-07-24" version="1">MKRYETDVREGVLHLETPGGWLEVGEMDAICELIGGETYTLEYDNRQRQVGWLDTDEDGRLSFEVRETIRDTTFDSEFVEAIANAPLDEDDEDGYPKRTAAFADMLTAIWDGKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYW4</accession>
    <name>R4VYW4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446330.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07455"/>
    <dbReference type="EnsemblBacteria" id="AGN01436">
        <property type="protein sequence ID" value="AGN01436"/>
        <property type="gene ID" value="L593_07455"/>
    </dbReference>
    <dbReference type="GeneID" id="16182129"/>
    <dbReference type="KEGG" id="sali:L593_07455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1523"/>
    <dbReference type="eggNOG" id="arCOG01449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087820_0_0_2"/>
    <dbReference type="OrthoDB" id="95811at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046260">
        <property type="entry name" value="DUF6293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19810">
        <property type="entry name" value="DUF6293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6293" evidence="1">
        <location>
            <begin position="9"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="27935" checksum="03733E4F9FBAC724" modified="2013-07-24" version="1">MDDLAVPDRIHVAPVGYENDRIVLPAAELAADRLVLLVYDDETDHPSYLPEVRERLDDRGIPHESIPCDIFDFYDSIGTVGQVVSEFADADVYVNLATGTKITAIGGMIACMATGATPYYVRAEAYGPLTEADVAEGVRSLVELPTYPMEYPDPQQVATLRHLAAEGAATKKQLIRFAESADLPALADHEARNRKGKYRRLDARVLDDLDDNGYVSLDRSGRSTRVSITDAGRDALRAFAYLDPTGSVDDRSDASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ04</accession>
    <name>R4VZ04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446370.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07655"/>
    <dbReference type="EnsemblBacteria" id="AGN01476">
        <property type="protein sequence ID" value="AGN01476"/>
        <property type="gene ID" value="L593_07655"/>
    </dbReference>
    <dbReference type="GeneID" id="16182160"/>
    <dbReference type="KEGG" id="sali:L593_07655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1569"/>
    <dbReference type="eggNOG" id="arCOG00446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_2"/>
    <dbReference type="OrthoDB" id="74513at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="31423" checksum="05D93136B0B8223E" modified="2013-07-24" version="1">MKLLALTKGVPDFSEGAVSFDEDGHLERGDTPTVMNPNDEQALEAALQTKVRHDGTVGLMSMGPPGYQDILEEGMRSVYADELYLLSDREMAAADTWATAITVATGIEQMEEEPDIVFAGFKTADGETGHTGPQTCWALERPLITHVISLDVDPDEEIVRAKRLVKGDVSEIETVEAPMPCAIVTDPEFEPVYRKAEHRLKHKDLRAETQERVENAEEHLTVWDHEDLNLDPDYIGLDGSPTIVSGVDPIPKAPDEREATVIEQDDQEGMREVVEEITQFAAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ07</accession>
    <name>R4VZ07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447394.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12805"/>
    <dbReference type="EnsemblBacteria" id="AGN02500">
        <property type="protein sequence ID" value="AGN02500"/>
        <property type="gene ID" value="L593_12805"/>
    </dbReference>
    <dbReference type="GeneID" id="16180187"/>
    <dbReference type="KEGG" id="sali:L593_12805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2627"/>
    <dbReference type="eggNOG" id="arCOG04545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536612_0_0_2"/>
    <dbReference type="OrthoDB" id="97111at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="19929" checksum="C65B29CB32EA5CE1" modified="2013-07-24" version="1">MAKVSVGLRGWRFEEDAVFDEDGEFLPLDEMDEDARDRLVRLAELVASPCDACWLVHGDENISECNVAEAVYGELSAEVIVCREHERDLVYWYREEGGKQYRGTEEFQDAFFEWFDDGGRAPEDFEGIEHVDTDPLEVPTPSVPDAEERAERWEVTDRIDLTDVDLDQDYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZC3</accession>
    <name>R4VZC3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_08305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446500.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08305"/>
    <dbReference type="EnsemblBacteria" id="AGN01606">
        <property type="protein sequence ID" value="AGN01606"/>
        <property type="gene ID" value="L593_08305"/>
    </dbReference>
    <dbReference type="GeneID" id="16182362"/>
    <dbReference type="KEGG" id="sali:L593_08305"/>
    <dbReference type="eggNOG" id="arCOG06218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775272_0_0_2"/>
    <dbReference type="OrthoDB" id="103577at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GIDE" evidence="13">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="357" mass="37102" checksum="E7A8B9279E4D32ED" modified="2013-07-24" version="1">MALDVGGIVSLLLLALLVLGPAAWVIHHYAVLQDFRTARTVFRLDATSLAVGGVLLAGSVALVVIAFEPAAPLAMIFGGTLLVFGIAGVTIAVANLDWYLASRRLPVDSPASVEPGPVQLEGRAVPLGEFVPSAVTQTDSLAYRGSTREEYAVLGRGYASSTWSAVSVAEGATRFGVVDPAAIEGVGDDEAATNGRELPAKFRAELDDPDVELPADVRPIAVDADAAEFPLLFPTSRLVELSPAGATLDGLERTIPAEPGTTVPVADELARGTRSRPREYSERRLDAGDPVYVLGTARETADGEIEIGPDPDGPPFVVTRLTAEAATAHARRFCRTYGLLGLASLAAGAGLIASVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W042</accession>
    <name>R4W042_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02880">
        <property type="protein sequence ID" value="AGN02880"/>
        <property type="gene ID" value="L593_14730"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14730"/>
    <dbReference type="HOGENOM" id="CLU_1709214_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="17159" checksum="B699806CC9474E93" modified="2013-07-24" version="1">MSLASSGVIVVVNNLVVFADQQSRVGLHVELSTLMPDVVHLGELDVDVLNFHQLSPDFTLRMFDCVNVHIRFLILHGVYEYLERFTLERPEKIVLRDRTGCVNAVEGNSPLNFPCVDTVLISLAKQKRDDITGLFALSGVNMCLSNSLKFRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0E7</accession>
    <name>R4W0E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446870.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10155"/>
    <dbReference type="EnsemblBacteria" id="AGN01976">
        <property type="protein sequence ID" value="AGN01976"/>
        <property type="gene ID" value="L593_10155"/>
    </dbReference>
    <dbReference type="GeneID" id="16182492"/>
    <dbReference type="KEGG" id="sali:L593_10155"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OrthoDB" id="65016at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="113"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="365" mass="40691" checksum="4E989454B471E0B0" modified="2013-07-24" version="1">MENEDSVRRGLQRIGLSQYQSEAYLAVIQHGPLAAVDVAEKSGIPSSRIYDVLTDLEHDGYVTTFEREDRRYVQATEPSDLVNVLRQTGEQLSETAEDIEEVWEQNSIDDHQVNLVKQVDSTLERARAFIENAETSVDVAATPSQYYQLREALATAHANDVVVRVSIEDVSPGQIDATQPVTELRRRGIPGPFVAIVDRTYTCFSPNDRAASDYGLVVNDRILSFIFRWYFQLCLWSVCDPIYVADSEGKMYVSLVEFVRDVYPLWLEGAMLPVTIEGTDPQSRDSRRVSGVVSGIRYPDMSLERGHVPTYSDLSSFLTLAVTDETGETHLVGGWGAVFEDLEADRIVVHGSKVVLPPSLPAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0M4</accession>
    <name>R4W0M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446985.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10730"/>
    <dbReference type="EnsemblBacteria" id="AGN02091">
        <property type="protein sequence ID" value="AGN02091"/>
        <property type="gene ID" value="L593_10730"/>
    </dbReference>
    <dbReference type="GeneID" id="16182543"/>
    <dbReference type="KEGG" id="sali:L593_10730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2212"/>
    <dbReference type="eggNOG" id="arCOG01923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_1_1_2"/>
    <dbReference type="OrthoDB" id="89321at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="169"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="31033" checksum="77228AB7B3CAAD17" modified="2013-07-24" version="1">MSDETAGSGWFAGLDPGDASGAAERIRRGSAAEPADWPAAAVESGTVPDEDAYYDLLHETTVAATRSAVAEAEGADDQQLAHLVRAMDDCNRIANELAERVAEWAGARLGESGSGVGFARRIANRDPGTGDAGADAGEKRLIGLAQRCADLDDEAEALRAEIERSAPQVAPNLSALAGPVLAARLISLAGGLEDLAKSPSSTVQVLGAEDALFAHLRGQGPSPKHGVIFTHDAVRGMPRENRGSAARALAGKLTLAARVDYYSGERKPELDEQLDARIERIRARTDDADSESGGDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W237</accession>
    <name>R4W237_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447595.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13810"/>
    <dbReference type="EnsemblBacteria" id="AGN02701">
        <property type="protein sequence ID" value="AGN02701"/>
        <property type="gene ID" value="L593_13810"/>
    </dbReference>
    <dbReference type="GeneID" id="16180855"/>
    <dbReference type="KEGG" id="sali:L593_13810"/>
    <dbReference type="eggNOG" id="arCOG03934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044346_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="27828" checksum="BC10E74C2CE9DE24" modified="2013-07-24" version="1">MSLEVGDAVSEAFDRITTQAALVLIGLYTITSVLQSAASQDVLREFVESIRDWGRDELTAEEYQELVDSTDPVLNDLPLALGLDLVPAIALWFVALVAGVAIVAVAIDAFAYGANTIDDLDTSRLLWRTLNILVGGLVFGILLFVGFAFLIIPGLIVFVLFVYFPVAVVVDDTNFVSALGNSLNTVTDNAGQTLLLIAVAIGVGIGIGIASSIVTFALPGTIAGIVNAAFSATSALFVLAILTRGYVAANAPEADEPVTGSEFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2F9</accession>
    <name>R4W2F9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">L593_14675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447765.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14675"/>
    <dbReference type="EnsemblBacteria" id="AGN02871">
        <property type="protein sequence ID" value="AGN02871"/>
        <property type="gene ID" value="L593_14675"/>
    </dbReference>
    <dbReference type="GeneID" id="16181409"/>
    <dbReference type="KEGG" id="sali:L593_14675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2996"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OrthoDB" id="12800at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="43501" checksum="D09824702483C9AB" modified="2013-07-24" version="1">MAHDAFITEMEIAGADDGPLAGATVAVKDNISTQGVPTTCGSAMLAEYEPPYDATVVESILDAGATVVGKTNMDEFGMGTTTETSAFGVTDNPAAPGHVPGGSSGGSAAAVADGEADLALGTDTGGSVRCPAAFCGVVGIKPTYGLVSRYGLVAYANSLEQIGPIAPTVEEAAALLDVIAGPDPNDATTREKGADSDYVDAADGDVEGLDVGIPTELLDGADDGVVETFWDAIDDLEAQGASTHEVSLPSLEHAVEAYYVIAMSEASSNLARFDGVRYGHSGGYDGNWNETFAKARREGFGDEVVRRILLGTYALSAGYHEKYYDQAQNARAWVKQDFDEALDDADVLASPTMPIPPFELGESLDDPLTMYLADANTTPVNLADLPAISVPAGETDGLPVGIQFVGPAFGEETIVRAGSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2K1</accession>
    <name>R4W2K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447820.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14960"/>
    <dbReference type="EnsemblBacteria" id="AGN02926">
        <property type="protein sequence ID" value="AGN02926"/>
        <property type="gene ID" value="L593_14960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180531"/>
    <dbReference type="KEGG" id="sali:L593_14960"/>
    <dbReference type="eggNOG" id="arCOG08201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682655_0_0_2"/>
    <dbReference type="OrthoDB" id="111021at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="16435" checksum="99292DB757EA545D" modified="2013-07-24" version="1">MASGRIFAASTVLLGGAALGHALFTWPWEVTAALFLGGALIAFVAEALVVSLGWLDHHVWPQFAGVPLYVLAGWTAVIYVALRIALLATSGVGAIVLTAAIATSYDVLTDNVGVENGHWTYTDDVPGPRHGEVPWWNYVGWFAISGVTAALAVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2L9</accession>
    <name>R4W2L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444921.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00027">
        <property type="protein sequence ID" value="AGN00027"/>
        <property type="gene ID" value="L593_00360"/>
    </dbReference>
    <dbReference type="GeneID" id="16179972"/>
    <dbReference type="KEGG" id="sali:L593_00360"/>
    <dbReference type="eggNOG" id="arCOG00513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124266_1_1_2"/>
    <dbReference type="OrthoDB" id="103265at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15912" checksum="DF36A77D4EA80A96" modified="2013-07-24" version="1">MTQHEPVDLTAEERADRLGTGGVGVLSLDTGTHEPPHAVPVSYGFDPVEEVFYFRLAVGGGSTKGDVNHREAAFVVHEENGDDWWSVVAHGELVRTDEESVSTASLEGLDRVRIPFVDAFEAPPEEISFAFVRLEPHELTGRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2X6</accession>
    <name>R4W2X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445091.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01220"/>
    <dbReference type="EnsemblBacteria" id="AGN00197">
        <property type="protein sequence ID" value="AGN00197"/>
        <property type="gene ID" value="L593_01220"/>
    </dbReference>
    <dbReference type="GeneID" id="16182601"/>
    <dbReference type="KEGG" id="sali:L593_01220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.248"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_2"/>
    <dbReference type="OrthoDB" id="59517at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="28851" checksum="F8A1302BEA52694E" modified="2013-07-24" version="1">MVVADLHVHTTNSDGTLDVADIPAAATRADLRAVAITDHDRPHPDLDAPLTVIDGITVVHGIELRVEATDQRVDLLGYGLDPTDALREECERIQQNRANRGARIVQRVEDHLGIDLEVEARPGLGRPHIARAVAEHPAVEYDLQGVFDELIGDDRPCFVARDVPSFETGRRLLADACRIVGLAHPLRYDDPEAALALTAELDAVERWYPYDRPADPGDTPALEPVERAIKQYDLLPTGGSDAHGTSLGAAGLNADAWERVEAALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W354</accession>
    <name>R4W354_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445216.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01855"/>
    <dbReference type="EnsemblBacteria" id="AGN00322">
        <property type="protein sequence ID" value="AGN00322"/>
        <property type="gene ID" value="L593_01855"/>
    </dbReference>
    <dbReference type="GeneID" id="16179970"/>
    <dbReference type="KEGG" id="sali:L593_01855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.375"/>
    <dbReference type="eggNOG" id="arCOG00447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_2"/>
    <dbReference type="OrthoDB" id="83858at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="324" mass="34312" checksum="6D4F8ACDDA887034" modified="2013-07-24" version="1">MSDVLAVAEHRRGELRPVSHELLTVGREVADASGGDLHVAVISGTVEEYAEDLNREGVDAIHTIANGEEFNHDLTVESLDALWADLDATYLLAPNSVNGLDYVPAIAQRLDLPLVTDTIDVSLDDGLEVTRERYGSKVETTIAVDVEAEGGAVVSVRDGEWPPAEGVGDAAIEAFDPQIDESRIRSTVTGFQEVGAGDVDISEADFIVSIGRGIEEEENIELIEALVEATGATLSASRPVVDNEWLPKNRQVGQSGKTVTPDVYIAIGISGAVQHVAGMKGSDTIVAINTDPDAPIFDIADYGIVGDLFDVVPALIEEFGGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3C2</accession>
    <name>R4W3C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445336.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02455"/>
    <dbReference type="EnsemblBacteria" id="AGN00442">
        <property type="protein sequence ID" value="AGN00442"/>
        <property type="gene ID" value="L593_02455"/>
    </dbReference>
    <dbReference type="GeneID" id="16180223"/>
    <dbReference type="KEGG" id="sali:L593_02455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.498"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="405"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="573" mass="59861" checksum="1B252A7B227E315B" modified="2013-07-24" version="1">MPTTAERLVDDLEAIGVEYLFGFPGGRVIELLEHVPDSELTLVRPRDEREASVMAEAYGRIAGDPGVLTGQGPWIGSIGAMGQMEGYLGSSPMVVLTEASERGEYSTLAPYQQARGDYGGIDLPTALSAYTKEHWFPRSPTETIRTLQLAVKHATAGRPGPTAVILDGDAVTAEVPGDPIPPVWDAEEQVQNWTSRPEATDVEAAAAALSAAERPVIVAGNGVHAADAYEELQTVAEAAGAVVTTSYLGKSTIPETHDLAAGVIGSFGHEGANQVVSEADVLLVVGSRLNPMDTNWQAPEFVRPDEQTILHADVDSRNAGWVYPADVGLIGDAASTLADLADALAERSADQPTADSSSWARERAAAARESFSVPECDSDATPIAPQRAIAEIDGVVDEETIVLADSGNNRFWLLNYLQAPATGTYYGSGGVGGMGWSAPAAIAAGLATDRDVIAVAGDGGFGMSLTAVETAVQYEVPVLFVVLNDTSLGMVRQMQGDGEIAGVEFGDTDFVAAAEAFGATGRRVVDPESLGDALAEGKAAEEPCVLDVGIDREADMAASLRSSFYESVGGLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3G5</accession>
    <name>R4W3G5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">L593_02830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445411.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02830"/>
    <dbReference type="EnsemblBacteria" id="AGN00517">
        <property type="protein sequence ID" value="AGN00517"/>
        <property type="gene ID" value="L593_02830"/>
    </dbReference>
    <dbReference type="GeneID" id="16180443"/>
    <dbReference type="KEGG" id="sali:L593_02830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.572"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_2"/>
    <dbReference type="OrthoDB" id="41305at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="133"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="497" mass="50370" checksum="8EC402FE75A71643" modified="2013-07-24" version="1">MITSDRMAAVDANAAALGVPRKQLMESSGNAVARAVRERTEPGDALAIVAGRGNNGGDAFVAARFLEDRDLTTLLLGRAETITTDIARENWDALQQAEQQTIEVRDTAALAGSDADAAAAIDEADLVVDAMLGTGVTGALREPAATATERINDASDAGATVVAVDVPSGVDADTGDAAGDGPHAAVEADHVVTFHDEKPGLADVAATVEVADIGIPDAAELFVGPGDLQALSRPEDSHKGDFGHVLVVGGGPYTGAPALTAQAALRAGADLATVACPESVADEVQGYSESIITKPLPGDRLLPGHVDRLLDLAADRTTTVIGPGLGRAEDTLDAAREFLAAASGTVVVDADPLRVVPDVVAETDATLLCTPHRGELVAMGGPEADDWRDRADAVEAFASDLGATLLVKGPYDVISGGETTRVNRTGNPGMTAGGTGDVLAGITGALVSTQRPVDAGAIAAYVNGTAGDAVVDERGYGMLASDLLAEIPLAMWGKTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3P2</accession>
    <name>R4W3P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription anti-termination factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00652">
        <property type="protein sequence ID" value="AGN00652"/>
        <property type="gene ID" value="L593_03505"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03505"/>
    <dbReference type="eggNOG" id="arCOG04687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112755_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="27913" checksum="CF1FB955A998B1B2" modified="2013-07-24" version="1">MHLRTPGEGVNVRWRSILQFERKLLSSVRTLNAVPKQQLRMDGEAFRERVTDEKATELDRLGSEKLLIALTDADLSEEGVLEAAAASEHSARNTFEQWADSEDDERAREVFADVAEQEAEHYERVAEHLPEDFEPADGGPLHAHLRQQDDAIARAAGLVGRGLVSDRTHLQVISFFVNEGDRRRANLFRDLREDTDGSLQSGLDLLESLCETDEDWETAAGVTEYTIQVAYDDYADALDGMGMDPKPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Q2</accession>
    <name>R4W3Q2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445566.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03605"/>
    <dbReference type="EnsemblBacteria" id="AGN00672">
        <property type="protein sequence ID" value="AGN00672"/>
        <property type="gene ID" value="L593_03605"/>
    </dbReference>
    <dbReference type="GeneID" id="16180626"/>
    <dbReference type="KEGG" id="sali:L593_03605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.732"/>
    <dbReference type="eggNOG" id="arCOG04638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032635_1_0_2"/>
    <dbReference type="OrthoDB" id="72467at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="25339" checksum="E4D7FF6A534B9271" modified="2013-07-24" version="1">MIPSDAGLVVFFLVGFFGGAHCLGMCGPLVTMYAERFESDGRGPTTSALRQHLLFNAGRTASYTVIGAFLGLLGGLLFDAGALVSAANGVRGVVGIFVGTFIVAAGIGYITRGQPRFTAGSIPGVGGLFATVSGSLHARIDDWAAGPGIVGLGAIHGLLPCPLLYPAFLYAAASGSPIHGGLALAALGLGTVPALFVYGTVLDTASPTVRGRLHRALGVVFVVAGTIPLAKGLGALGYAVPHVPLPMPPMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W415</accession>
    <name>R4W415_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">L593_04505</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445746.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04505"/>
    <dbReference type="EnsemblBacteria" id="AGN00852">
        <property type="protein sequence ID" value="AGN00852"/>
        <property type="gene ID" value="L593_04505"/>
    </dbReference>
    <dbReference type="GeneID" id="16180978"/>
    <dbReference type="KEGG" id="sali:L593_04505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.918"/>
    <dbReference type="eggNOG" id="arCOG02957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208205_1_1_2"/>
    <dbReference type="OrthoDB" id="128075at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="5705" checksum="532212662512F95A" modified="2013-07-24" version="1">MSGSGQNSGGLMSSAGLVRYFDSEDNNAIRMDPKSVMAFGVLLGAFVQTLTIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W485</accession>
    <name>R4W485_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445871.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05140"/>
    <dbReference type="EnsemblBacteria" id="AGN00977">
        <property type="protein sequence ID" value="AGN00977"/>
        <property type="gene ID" value="L593_05140"/>
    </dbReference>
    <dbReference type="GeneID" id="16180267"/>
    <dbReference type="KEGG" id="sali:L593_05140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1048"/>
    <dbReference type="eggNOG" id="arCOG04704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079334_1_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="28509" checksum="C5F2FC75F70493C2" modified="2013-07-24" version="1">MDEPVVLTGAGGRVGAAILEGIGEDYDWRLFYHSHPDEVLADGEVIVGDVVEEEKVRDLVEGAGAVIHLAGDPRPEAPWDSVLENNIHGTKVIMEAAADAGVEKFVYASSNHAVGAFETSERTPEMYRPGDDFRLDGTELPRPSNLYGVSKATGEILGRYYYDHSEMDVCSIRIGNLTRNHPPKEYERGQAMWLSYRDCAHLFERSLEADYGHAIVYGISDNERKYYSLEGAREILGYEPQDDSADFTFEGEPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4N6</accession>
    <name>R4W4N6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA/RNA helicase, superfamily II, SNF2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446116.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06375"/>
    <dbReference type="EnsemblBacteria" id="AGN01222">
        <property type="protein sequence ID" value="AGN01222"/>
        <property type="gene ID" value="L593_06375"/>
    </dbReference>
    <dbReference type="GeneID" id="16181712"/>
    <dbReference type="KEGG" id="sali:L593_06375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1299"/>
    <dbReference type="eggNOG" id="arCOG00871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009519_0_0_2"/>
    <dbReference type="OrthoDB" id="47433at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="118"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="468"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="876"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="968" mass="110448" checksum="4CFFD0D9FB19F14E" modified="2013-07-24" version="1">MDSLNPGDAVRLNGTPAEVIKTYAVGDLEYIRAYVDGDGVKTVCIDDVEIEPKPDQLAALDPATADDLHPDHDAVSAEWFDLRSQALQLQIAHEQGQLLSISNSRVRLEPYQLAAVNWVMQKLRQRALIADDVGLGKTIEAGLILKELTARNRADRVLFVVPAHLQKKWIRDMDRFFDVDLTPADRQWVEGERRRLGEEANIWDQDHQRMVASQAFLRQDEFQPALDEAFWDVVIVDEAHKAAKRGESPSETSKMVERVAGNSDSCLLLSATPHDGKGEAFRSLVEYVDPFLVAEDRELSREAVDRVMIRRGKQTIYDDDGERIFPDRTVNTVPVEMTHEERQFYQAVTEYVQHVYNRSEQLNEPAVGFAMALMQKRLVSSVGAIQATLSRRLGDLVEEQSTATSLSAEATAYLDGEDLDEADKQAAEDELSALTVTESDAQLEEEIETLRDLVGLAENISVDSKGQKVRRYVQQLLEEQPDEKLLLFTEYRDTLDYLLELVEDEPWADEILVIHGDVDKADRARIEDEFNHGESRLLFATDAASEGIDLQHSCHIMVNYELPWNPNRLEQRIGRIHRYGQDKEVKVWNFSFEDTREGEIFEMLQNKVESIRGKLGNTADVLGMLDDVDVDSLIMESIRNEEPPGATKEELEELIDERQRTLQEWYERSLIDTSTFDQESREKIQEVMDQSEDVYGSEADIREFVERGVEALGGSVETTGTDLFRAELPASLRTGMEEEYGPFTFSRDFAMDHDGIEYVSPDDDLVQRLMQEVLESDRGDVGLKLLPFVDEPGIVYTYRLRFEDGTGAVIREELLPVYVDARHQDTRQRLGERIVAGDSVTGTHDADRVRSLIQSQEQLRSAADRYSSQTVRSLREELHERRRSETQQELDDLEAYADTERERIRAFIDEYERKADAGTDMDIAIRGQRDRLSKLEQRIEDRREELERKAQVISLAPEVESICLALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5K8</accession>
    <name>R4W5K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446681.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09210"/>
    <dbReference type="EnsemblBacteria" id="AGN01787">
        <property type="protein sequence ID" value="AGN01787"/>
        <property type="gene ID" value="L593_09210"/>
    </dbReference>
    <dbReference type="GeneID" id="16182826"/>
    <dbReference type="KEGG" id="sali:L593_09210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1891"/>
    <dbReference type="eggNOG" id="arCOG06245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061976_0_0_2"/>
    <dbReference type="OrthoDB" id="25581at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037595">
        <property type="entry name" value="RGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31682">
        <property type="entry name" value="PTHR31682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03214">
        <property type="entry name" value="RGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="45319" checksum="9307DA257C2201A5" modified="2013-07-24" version="1">MQPDVCVIVPTIREYECLEAYVENAHQHGFDTDRLHVVLVTEDFCDTDAMRAMLDDLGVSGEVFDGTAREAWFAEQGISEYEDLIPEASHAQTSFGLLYMWANPQFEYGVFVDDDTLPHEEWDFFGQHLANLAFEGEVEEVSSDEQWVNVLYQNADEHGLYPRGYPYSAMHETVETDTAHVDTVVASQGLWTNVPDLDAVRILMDGDLEGQAQTRTEFSDFGEDFVAADGNYLTVCSMNLGFRREVIPAFYQLPMDDNEWAVGRFDDIWSGVFLKRACDLLGARIYNGQPLCEHNKAPRSTFDDLHNEVAGLELNEHVWELVDDVEPAAISEGSIDRDAAAVPSPESFAAVFEAMGHELATGDYSQWRNGEFLNLVGETMLDWLDCLDRIEPVAAEPVPVAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y1</accession>
    <name>R4W5Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444947.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00490"/>
    <dbReference type="EnsemblBacteria" id="AGN00053">
        <property type="protein sequence ID" value="AGN00053"/>
        <property type="gene ID" value="L593_00490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182404"/>
    <dbReference type="KEGG" id="sali:L593_00490"/>
    <dbReference type="eggNOG" id="arCOG08975">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_2_0_2"/>
    <dbReference type="OrthoDB" id="114503at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9670" checksum="A23AA4929D716D9E" modified="2013-07-24" version="1">MAAVEATVYTRSNCDLCDDAVETIETIAAQEDVDLDLSLVDVDEDPELRDEYGERVPYVVLNDRPAFKYSVDPASARSKLRALAADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W646</accession>
    <name>R4W646_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447001.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10810"/>
    <dbReference type="EnsemblBacteria" id="AGN02107">
        <property type="protein sequence ID" value="AGN02107"/>
        <property type="gene ID" value="L593_10810"/>
    </dbReference>
    <dbReference type="GeneID" id="16180751"/>
    <dbReference type="KEGG" id="sali:L593_10810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2229"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_2"/>
    <dbReference type="OrthoDB" id="79386at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="191" mass="21101" checksum="3DE52E8E3108E6CB" modified="2013-07-24" version="1">MDLSTSDGALVVVDMQNGFCHPDGSLYAPGSEAAIEPVADLVDRAHDAGVQVVFTRDVHPPQQFEDAHYYDEFEQWGEHVLDGSWEAEIVEEIDVRDVDHVVEKHTYDAFHETELDGWLSARGIDDLAFCGTLANVCVLHTAGSAGLRDYRPVLIEDAIGAIEDDHREYALEHADWLFGEIGTSDSLSMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W694</accession>
    <name>R4W694_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_01325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445112.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01325"/>
    <dbReference type="EnsemblBacteria" id="AGN00218">
        <property type="protein sequence ID" value="AGN00218"/>
        <property type="gene ID" value="L593_01325"/>
    </dbReference>
    <dbReference type="GeneID" id="16182853"/>
    <dbReference type="KEGG" id="sali:L593_01325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.270"/>
    <dbReference type="eggNOG" id="arCOG00626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_2"/>
    <dbReference type="OrthoDB" id="36317at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="8">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="300"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="39887" checksum="1FC303D925F78C82" modified="2013-07-24" version="1">MVDLATAIRLVAGVGLLLGNGFFVTTEFALTRVRQFDESEFEGRGLELAWEMTEKLEIYLSGCQVGITICSVGLGFVAEPAVAAVLDPVLHEIGLTSPSGAGHSALAVGTSLAIINLLHVIVGEQAPTYLGIERTKFVAQYGAPVLFAWTKVMSPVILLSDRVAKGLLGLFGVEIGRSWTEEELEEGEEGAMTRGELRRRMGDALSQVEDLPPERREEVLGALDIGTIEVEDIMIDESEILAVSTADPLETNLERIAESPHVRFPVVGESLDDFRGVLYTPLVLRHLEELQEGTLDLEELATPPMTVSPEATVAALIDQFQRENQELAFVTEPTDADGDDRVLGLVTATDAFEQITGDLEDPMDVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W697</accession>
    <name>R4W697_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rps28e</name>
        <name evidence="4" type="ORF">L593_01350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445117.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01350"/>
    <dbReference type="EnsemblBacteria" id="AGN00223">
        <property type="protein sequence ID" value="AGN00223"/>
        <property type="gene ID" value="L593_01350"/>
    </dbReference>
    <dbReference type="GeneID" id="16182603"/>
    <dbReference type="KEGG" id="sali:L593_01350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.275"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_1_2"/>
    <dbReference type="OrthoDB" id="121548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="7922" checksum="7C0496D53387FA07" modified="2013-07-24" version="1">MSAEESEAGSTPAEVIEVVGKTGMHGEAMQVKCRIREGDNQGRIITRNVLGPVREGDVLQLRETAREADSIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D3</accession>
    <name>R4W6D3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">V-ATPase subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpC</name>
        <name evidence="10" type="ORF">L593_01810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445207.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01810"/>
    <dbReference type="EnsemblBacteria" id="AGN00313">
        <property type="protein sequence ID" value="AGN00313"/>
        <property type="gene ID" value="L593_01810"/>
    </dbReference>
    <dbReference type="GeneID" id="16179955"/>
    <dbReference type="KEGG" id="sali:L593_01810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.367"/>
    <dbReference type="eggNOG" id="arCOG02459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059311_0_1_2"/>
    <dbReference type="OrthoDB" id="75042at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00314">
        <property type="entry name" value="ATP_synth_C_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014272">
        <property type="entry name" value="ATPase_V0-cplx_c_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02923">
        <property type="entry name" value="AhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="40034" checksum="00938219A2C746AC" modified="2013-07-24" version="1">MSPTSTTRDSTGSSNPEFVNARVRSRRAALFDDEDYRKLVRMGPGGIARFMEESEYETEINALASRHDGVDLIEYALNRNLAKHFDDLLRWAEGELHELIAKFLRRYDAWNVKTAIRGVYSGASPDEIRVDLIQAGALDDATLDRIVEADSIEEIVETLEGTIFGEPLEAAYDEFESRDVLVPLENAVDRAFYSDLLAGVEKGQQREGPTALYEEFLVAEIDFLNARNALRVARSGANIDPEEYAIEGGELFGADELRAVGGDLDQLVELLRESDYGDQLSTALDGLRDADSLIQFEHALDAALLEYTDHLSHVYPVSITAVMSYVLAKTREVENIRAIARGKEVGLDQQQIEDELVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D9</accession>
    <name>R4W6D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multifunctional long-chain (E)-prenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445217.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01860"/>
    <dbReference type="EnsemblBacteria" id="AGN00323">
        <property type="protein sequence ID" value="AGN00323"/>
        <property type="gene ID" value="L593_01860"/>
    </dbReference>
    <dbReference type="GeneID" id="16179980"/>
    <dbReference type="KEGG" id="sali:L593_01860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.376"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_3_2"/>
    <dbReference type="OrthoDB" id="59203at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="29863" checksum="A361C2A03129B77D" modified="2013-07-24" version="1">MEFLQRRRSLVEDRLTEVVSAVDPAELSAEMEHVALAGGKRVRPMVTILACEAAGGEPEDAVEFGVGVELVHNASLVIDDIIDRSEVRRGTDSAWFAFGHGPAIVASDGLLGEAFAQFANDGQATEVVTAAMVELGEGEATELQAIPDGEAEYLELARRKTGALFRAAAELGAIAADADQEAIDAFGEYAERVGVAFQIRDDVLDATAAADDLGKPTGQDAAMDRPSIVHVTDLDPEAANDRAREEADLALAALDRVELENDTAEGYLRDLAEFVVVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F4</accession>
    <name>R4W6F4_9EURY</name>
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        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447171.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11670"/>
    <dbReference type="EnsemblBacteria" id="AGN02277">
        <property type="protein sequence ID" value="AGN02277"/>
        <property type="gene ID" value="L593_11670"/>
    </dbReference>
    <dbReference type="GeneID" id="16180763"/>
    <dbReference type="KEGG" id="sali:L593_11670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2405"/>
    <dbReference type="eggNOG" id="arCOG01080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101758_3_0_2"/>
    <dbReference type="OrthoDB" id="113704at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="166" mass="18132" checksum="FCAD7018B6AD0DA4" modified="2013-07-24" version="1">MEQTRHFTATTYVVVEGAVALHRHVRIGKWLPPGGHVDRGELPHEAALREVEEETGLDATIVAEQDDVGSPTVEPLPQPHHLQLADVNIYGEAGSADAQVGHQHVDLVYYAAADERTIDPASDEEPADAWEWFDADDLAEDGALDPDVAEIGQRAIATVGEWRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I2</accession>
    <name>R4W6I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447236.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11995"/>
    <dbReference type="EnsemblBacteria" id="AGN02342">
        <property type="protein sequence ID" value="AGN02342"/>
        <property type="gene ID" value="L593_11995"/>
    </dbReference>
    <dbReference type="GeneID" id="16181990"/>
    <dbReference type="KEGG" id="sali:L593_11995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2468"/>
    <dbReference type="eggNOG" id="arCOG01809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479528_0_0_2"/>
    <dbReference type="OrthoDB" id="8691at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="101"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="580" mass="64328" checksum="80C75F5E1E008C1F" modified="2013-07-24" version="1">MSTSGSNPGATKGNLLLGAQAILDSYEEMDMPMERYLLLVIAPAASFFVFTLVATLQVPLPLVLRLPIPGLGFLGVVAAVIYPKLAQNRAKAAIGDRLHLFVTHMTILSTTNIDRVVVFRKLANEQEYGPLADEMRRIVELVDTWNQSLDDACRMRARQVPNDALADFLERLAYTLNAGQELGDFLLAEQDMIIRNYVTHYRSSLDNLEVLKDLYLSMILSMTFALVFAVVLPILTGSNPTVMVAAVIMMFFIVQLGFLYAVRVMTPNDPVWYQDDEKRLPYDLRVVASLAIAIVLMLLIVVLAILSALGVPPLPPSIHASIPLPFYVAIPITPLLVPGIVIRREEQRIRSRDEEFASFIRALGASESVKQSTTSNVLSTLRTREFGPLTDTIDNLYKRLNIRIDTLWAWDYFAAESHSFLIQKFSEMYVVGREMGGDPKVLGELISKNLSEVLQLREQRAQSTVTFVGLLYGITAAAAFAFFIGLEVVNVLTAMSAGLQTPDNMAVGNIIYPDIYNIPLIEFLLIMLVLINAMISSLMIRAADGGNSANAYMHFVFLTWIGATVGWFTRTMIGVFLQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K0</accession>
    <name>R4W6K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoamine oxidase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445332.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02435"/>
    <dbReference type="EnsemblBacteria" id="AGN00438">
        <property type="protein sequence ID" value="AGN00438"/>
        <property type="gene ID" value="L593_02435"/>
    </dbReference>
    <dbReference type="GeneID" id="16180231"/>
    <dbReference type="KEGG" id="sali:L593_02435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.494"/>
    <dbReference type="eggNOG" id="arCOG00774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_0_0_2"/>
    <dbReference type="OrthoDB" id="106288at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="17171" checksum="5F5CC9A1D90D7EFB" modified="2013-07-24" version="1">MPYSYEPHHFEDFETGQTFESVGRTVTETDFVNHSALTGDWTELHTNAEYAEDNVFGERIAHGPLTFVLTTGFVYRTGIVERTALAFLGMNYMDIPEPVHIGDTISADFEVTKTKEVGRDDAGLVVLDSVVRNQEDTVVFEGDMKFLIKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N6</accession>
    <name>R4W6N6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_12465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12465"/>
    <dbReference type="EnsemblBacteria" id="AGN02432">
        <property type="protein sequence ID" value="AGN02432"/>
        <property type="gene ID" value="L593_12465"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2563"/>
    <dbReference type="eggNOG" id="arCOG02350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06918">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
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        <location>
            <begin position="412"/>
            <end position="483"/>
        </location>
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    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="486"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="606"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="679"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="795"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02432.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113359" checksum="BE343270AAD8F8CC" modified="2013-07-24" version="1">MVASFGRNTTFSSPPGDEEPISILHVDDNVDFGEMAATFIERNHDRFDVEVAASATEGLERLAEADVDCIVSDYEMPGMNGLEFLEAVREEHPGLPFILFTGKGSEDVASEAISAGVTDYLQKKSGSDQFTVLANRIENAVTQARAEHRLEESQRRFRTLLSNVPGMAYRCRNERGWPMRFVSDGCAELTGYERSDLVDGEVSYGRDVVHPDDRDRVWESVQDAVAAREPFRVEYRIRTADGAEKWVWEQGQGVFEDGEPVAVEGFITDVTDRKESQERLEYQSSLLEAQMETTIDGLLIVDEDRTVVSYNDRFAEMWEIPEELVGAESEGALLDWAVENKVAEPEAFRDHVEKLYEGTEETSRDEVRLTDGRVFDRYSAPVIGDDGTNYGRLWVFRDITERKEHEQELERKEFLFGRVQEIADVGVWELDPETDDLTWSDGIRHIHGVPDDYEPNLEDAIDFYHPDDRDDIASAVTRAIEDGEEYDLELRIVRPDGTVRDIRARGEVSTDEHGETDLVRGVFQDITEQKERERKLQIYEYACRSALSGIAIANFDGELRSVNPAFCEMWGYEEKADVVGRSVTDFWDECNAATSVVDAVKETGSWEGELKAVRDDGTTFDAYSSASYVTNDEGESIALMSSFVDVTDRKRRERELEEEREKYATLVEQSHDGVLIIQNAEFVFVNSRLAAITGYKEAELRGMTFADIIAPEERRRIQERYERRLDGDADSPPSRYTLTFETKEGRERVAEVSAARIQYEGAPADLASVRDVTDREQYEDRLERLNEKLQVLNRVVRHDIRNDMAIMLGWGEQLEAHVDDAGAEHLEKILTSGEHIVELTEIARDYVETLTSEEEVDLKPTRLQQVLANEIALRREAHPDAEISVDAPVPDVAVRANEMLSSVFRNLLNNAVQHNDEDTPMVEIGAEEREDDVSVAIADNGPGIPEAQRERIFGRGEMSLESSGTGIGLYLVQTLVDQYGGDVRVEDNEPEGAVFTVTLPKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y9</accession>
    <name>R4W6Y9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447491.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02597">
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        <property type="gene ID" value="L593_13290"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2719"/>
    <dbReference type="eggNOG" id="arCOG04512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641945_0_0_2"/>
    <dbReference type="OrthoDB" id="53108at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="439" mass="47578" checksum="FEAE34360398C42A" modified="2013-07-24" version="1">MTLPDRDAVSRREFLQAAVAVGGAVGLSACLEASGGGDEQVDAPTGGDLDSLPARQHAWNDVLDRDVDGNVDPPDHHVLAELSLTSDAERSADGQPTEAAREAVESTFRELERAIAWQTDGLLFTAGYTPAYFDRYEEPLPESVDLPEPQALTSLEIPETMDFDTHDLTVHLASDDPAVVLAAEEALLGNRETLNGLEMATSVDGVLEEVDRTTGFVGPGLVAEKQAEGEIGGLPEHDIHEEAPFWMGYRSGFQESQATEDFVTIDDGPFADGTTQHLESDRLQLGAWFDQDSHHERVSKLFSHVHAEEERVGEFGEKLGTSTNVLEVVDDTAEDARDPGVVGHAQKAARARVDGEPPLLRRDFNTTDGDYPGVHFLALQDGISTFVRVREAMAGEDLAQNGAVGSRQNNGILQYLSVQRRGNYLLPPRALRALPTPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W717</accession>
    <name>R4W717_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrous oxide reduction lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03685"/>
    <dbReference type="EnsemblBacteria" id="AGN00688">
        <property type="protein sequence ID" value="AGN00688"/>
        <property type="gene ID" value="L593_03685"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03685"/>
    <dbReference type="eggNOG" id="arCOG04012">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096026_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41247">
        <property type="entry name" value="PTHR41247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="22924" checksum="0270827DAB30BC2B" modified="2013-07-24" version="1">MPRHTHCTDHAHSTDDEGRTSDAPAGSEGDGITRRRVLHGAGAVAVAGLAGCIGGDGGGDGDDAPAAITVPDGATCDVCGMVIVQHPGPTSLIFYEDEQPAGHDNPARFDSTWEAFQFDFERSGWSRQAFYVTDYSAVDYEIRSDDGQQLISRHAAAGDFADANDVTFVVGSEVLGTMGRDLIAFSEESDAESFADEYGGDLGTIDDVTPELISSLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W745</accession>
    <name>R4W745_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin efflux carrier family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445617.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00723">
        <property type="protein sequence ID" value="AGN00723"/>
        <property type="gene ID" value="L593_03860"/>
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    </dbReference>
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        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
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        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="31080" checksum="A2B9A3C2DFC711F0" modified="2013-07-24" version="1">MSLLLSLLAMLVLLAAGIAARRVGILDPTRRERLNAFAYYVALPALILSSTYDQPLSEVLSGRLVVGVAGTLLVIAGIATLVYRREVDPGVRSVATVQSYHSNLGYLGVPVVATTFGGLATAKAALILGVAALVQIGLTITILTTANDAEASLTSELGGVVTNPAIVSVIVGLAASVAGIAIPELADAGLGYLGELALPIALLCVGAALTLEADEIPFGTVSTVVVLKLVAMPIVALGAFWLVGANDSTIRAGVVMMAMPSAVSTYVFASELGGDRKLASLNVFATTVFSVGSLLLVVQIVRAIV</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN00793">
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    </dbReference>
    <dbReference type="GeneID" id="16180027"/>
    <dbReference type="KEGG" id="sali:L593_04210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.856"/>
    <dbReference type="eggNOG" id="arCOG00717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_1_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="18839" checksum="8442F6224197FF67" modified="2013-07-24" version="1">MYVFDATPLIYLATVERLSLVLEHVDDAVLPERVHEEVVVRGNEEGHADARRIERVVDTGSLRVVSASGNDVFGRIARNQQLTDADAAVLAIADTNNAVAVMDEQYGRDVADAEGIRTRGTAFLVLRLLREGILDAEATRTIVDEMVEAGWYCAPNLYARILGKIEELETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W785</accession>
    <name>R4W785_9EURY</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0146 family.</text>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04385">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148458_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005353">
        <property type="entry name" value="UPF0146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03686">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="15217" checksum="5BC155F594C99918" modified="2013-07-24" version="1">MSDADRTTALADALIEGVRSRQSQESGGGVEPAALLEVGIGERTGIAATLLDRGIAVSAVDVVARAVPDGMAFQRADVTELDAAEFEGIDGVYALRAPPELHRPIADLARTLDVPAAFTTLGGDPPIVPVRPEQLPGGETLYWVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I6</accession>
    <name>R4W7I6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02932">
        <property type="protein sequence ID" value="AGN02932"/>
        <property type="gene ID" value="L593_14990"/>
    </dbReference>
    <dbReference type="GeneID" id="16180876"/>
    <dbReference type="KEGG" id="sali:L593_14990"/>
    <dbReference type="HOGENOM" id="CLU_1801777_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="143" mass="14462" checksum="82B7B66EA79EF8C7" modified="2013-07-24" version="1">MVEASLAASAVLTGLAVLGILAVLTLTRRRHPSMLGQEAAGSGFISQRQQTKSWAASTDALFAAFALLTIGAFGTVIFYVNGNGFEDPYMLLSVVALGIGVLLGSYSLGENAGIGSAGATFVTALVIAVILVAVVAMNLITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7P0</accession>
    <name>R4W7P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445977.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05670"/>
    <dbReference type="EnsemblBacteria" id="AGN01083">
        <property type="protein sequence ID" value="AGN01083"/>
        <property type="gene ID" value="L593_05670"/>
    </dbReference>
    <dbReference type="GeneID" id="16181462"/>
    <dbReference type="KEGG" id="sali:L593_05670"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_0_0_2"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="41980" checksum="0F5B8E6C92BDC45F" modified="2013-07-24" version="1">MARETRKIQKVGGSTFSVSLPKDWARARGLDAGSLVTLFAHPDDVLVVQPGDDDRETERTVTVAHESPQRLERLLRSAYAAGVDAIRFEATESLTREQRRAVGRVTDDLPGTTVVQEREDLLAIRVLLDGSEVSIQQSVRQLAFVASSTHRDAVGALVGEADPDAIDRGAEADRLFALVDRHFQRGCSEIGTLDALDSSRPELAVLRATARELQAVAADARRLGNLVETHGQGQDVDDARHQSGTDADHTAPLADDDLAEAFERLGERARTVLERATDALVAEDGTDDARSALARHAALEDALDETERALFAAEPDVWQGRALEHCRRTADHGATVAQLALRGALRRGDLDAAAPPDPADGSVGAAGVPGVIDGESTEDGVSVDGPDVAPDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q5</accession>
    <name>R4W7Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446012.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05845"/>
    <dbReference type="EnsemblBacteria" id="AGN01118">
        <property type="protein sequence ID" value="AGN01118"/>
        <property type="gene ID" value="L593_05845"/>
    </dbReference>
    <dbReference type="GeneID" id="16181509"/>
    <dbReference type="KEGG" id="sali:L593_05845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1197"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_2"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="39528" checksum="EF26D7D4A60EDDC7" modified="2013-07-24" version="1">MTDGGNAMFEDAEATDVGPAQQFKEVLYEGVVAPAKIAWSDWRTKTGIVILGSFVVIALLVMSHRNGIDILNTLIGPVSPWELAEPTSSYGCSGGKGGECAVGYPNSRQPFTYWDTPLGTDGSGRDLLSAVIWSTPRMLKMIVAGGVFSIAMATIVGTVAGYKGGTTNTVLMTLTDIGMSIPGLPLVIVLIAVIDPQSPYVIGTLIVINVWAGLARTIQSQVLSVREQSYVEASRTMGVSTPRIIQKDILPNLMPYIMVNFVYAARRVIYDSVALFFLGFLTFETIANWGLMMQWARANGNALTVPEARYQILVPMVPIVVLSFGLILLSQGTDRLFNPRVRTRHEGETVEEEGEDEEIQPAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S3</accession>
    <name>R4W7S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446052.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01158">
        <property type="protein sequence ID" value="AGN01158"/>
        <property type="gene ID" value="L593_06045"/>
    </dbReference>
    <dbReference type="GeneID" id="41054659"/>
    <dbReference type="KEGG" id="sali:L593_06045"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444729_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="2">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20922" checksum="8EDC5DED2C4FCF7A" modified="2013-07-24" version="1">MTDDTPDYSALEPPDGKAPQEYTHHERRAAILRHLIEVGSPAGVTQARLAERYGVHESTISRDMDRLRESVGEHLGTEAKFTTRTLYYHVVEELLAADDWRATKAAWDVAMDWNEWLAEIGEQRREPDRSEVDVDMRSRAVDVEYTVVREGDDDLPTTADGSPDHAALGFTAAPAVPEETGQEACDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T4</accession>
    <name>R4W7T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444938.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00445"/>
    <dbReference type="EnsemblBacteria" id="AGN00044">
        <property type="protein sequence ID" value="AGN00044"/>
        <property type="gene ID" value="L593_00445"/>
    </dbReference>
    <dbReference type="GeneID" id="16182122"/>
    <dbReference type="KEGG" id="sali:L593_00445"/>
    <dbReference type="eggNOG" id="arCOG00769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_1_2"/>
    <dbReference type="OrthoDB" id="63857at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21020" checksum="4BC6818CC8AA2658" modified="2013-07-24" version="1">MDSSETTSVEVVVFNGFDELDALGPYEVLENAKDAGANLDVELVTLGGATSATGNHDLTVASQGALSDHADLLVVPGGSWDGRAVAGAWAEVQAGDLPEAVRLAHQRGAIVGSVCTGAMILEAGGLLDGKRATTHHGAMEDLRESGAEAVDARVVDEGDVVTAGGVTAGLDLGFWLVERFWGVDLADEIAREMEYERSDDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T9</accession>
    <name>R4W7T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444958.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00545"/>
    <dbReference type="EnsemblBacteria" id="AGN00064">
        <property type="protein sequence ID" value="AGN00064"/>
        <property type="gene ID" value="L593_00545"/>
    </dbReference>
    <dbReference type="GeneID" id="16182806"/>
    <dbReference type="KEGG" id="sali:L593_00545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.111"/>
    <dbReference type="eggNOG" id="arCOG06201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604981_0_0_2"/>
    <dbReference type="OrthoDB" id="20790at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
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        <location>
            <begin position="410"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="50778" checksum="A8759171391985D3" modified="2013-07-24" version="1">MADVYYLVSDLHIGGDEQLRTVDFLEEFLAFLRDLETTDEDAELLINGDAFGLWEFTGVEGPAKFDELLAQYPELFEQLRATGETVPITLIPGNHDYELAAYDEYVDRLAEYNVRLRQVESITRTVGDFTVYVEHGMQRDPSNRIPDFGNPFANPPGYFVNQHVTSRAGQLSARGKYNWLKDIQAVTPMTMIPEWLISNYFYREMSPFLRYAAVPFLLLFNVGLAYVAIFVLDYVGIWSLPMNVVQDVLADFGPVGRLLDVFLTANLVVLGLLVAVSVPLYVLFRDVRSTLRRFGLLSPGGRAQPSRDPYLEGARDVFEDDSSVAAFVYGHTHRASLTTIGNRVVCNTGTWLKRLRRVGSVIGVLPPVFYASYRLNYFRFSSTDDGAVVVEYESVQKPDPDDETLLERLVTRSPAPPEPIPDRTVVDPANDRLTSSADEVAASDDQPTRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U7</accession>
    <name>R4W7U7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01203">
        <property type="protein sequence ID" value="AGN01203"/>
        <property type="gene ID" value="L593_06270"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06270"/>
    <dbReference type="eggNOG" id="arCOG14677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014177_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="274" mass="31314" checksum="069152126FAF819C" modified="2013-07-24" version="1">MTESGWQVRINGRRVIESNLVLNDDDGLVLVEEGGDSLTDIDKETVENFVDLFNWIYRSRSTDRISVFRNIATLYSTSISGMFTEIEDIGESVKSNFEFYIRDSIEEFVEVQQDVTEYVLNTHRELSDIRRGLANNLNRDLFRMVAYVAITWAGILSQVSGVTAIQTALIVSLVPVGVYVLLGLRTTYSLSQQFQAVEDGRNQYYSMYENRIDENTFSEIKDADGSENMKHQFKIDLWIYYVLFTLMLILCLLAVLDLAILEGPLTGFIESIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V1</accession>
    <name>R4W7V1_9EURY</name>
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        <submittedName>
            <fullName evidence="9">Monovalent cation/H+ antiporter subunit E</fullName>
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        <name evidence="9" type="ORF">L593_00720</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AGN00099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00099">
        <property type="protein sequence ID" value="AGN00099"/>
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    </dbReference>
    <dbReference type="GeneID" id="16181916"/>
    <dbReference type="KEGG" id="sali:L593_00720"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069531_0_0_2"/>
    <dbReference type="OrthoDB" id="42063at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="44121" checksum="3763D81B896AB8FC" modified="2013-07-24" version="1">MSEHSGGRDHDAPGAAVDVLVPVAPSATLRETVEYVVDSTLERVESAAGGSSSDEDSGPQADSRPSDAPDAETPPAPASPPPAIHFVYVHAPDEFDPDDETPALDDADELLDRVRVWAEEDAGGEEYLDVHTGHVGSDRYLFSPADVAAALIDAARERGVERIVLDPEYDPGVGAPLLRPLTYELSRDSTLTIEEAPVQQQVRRAPLVGRSSARRIGTLLGLSFLFYQVLAGAFSAFDLVTGGITAIVVAGSLSRISFGRDPTLTDTPLRVARGILYLPYLFWEILVANVAVAAVILDPRRVIDPQMTRIRPAVYGALPITSLANSITLTPGTLTVRVQGRELLVHTLIPGAREDLFDGSLERAIRFVFYGRRAMRIDSLRDRDAAEVVTGPAPSTDASRVDGQDGSGGDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W817</accession>
    <name>R4W817_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01423">
        <property type="protein sequence ID" value="AGN01423"/>
        <property type="gene ID" value="L593_07390"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1510"/>
    <dbReference type="eggNOG" id="arCOG07560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648334_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="423" mass="39918" checksum="EB613583C76A5DC3" modified="2013-07-24" version="1">MIAAVAIAALLAVAIGSLGGVAAADPDAGCVGTERGTPFQTDGGFTVWYNDSEPMPGSGPFVDDQTLRFRNVTLSSGGATELVLEDGTGPETCLGGIDATAAPIVIDPDGEQAVRVAGQVRALSVADAQFGDGAADFAYDATSDWTIEVTDTGFGGGTTIEAVDASGSTLATGTVDSSGALGLTLPAGTNEVALRAESGNQSDGGTDGGSGSGDDGDGSGDGTTDGNATDDATDGGSTNDGDGGSTNDTDGSGSDGSSDTDGGSASGTDGGSDGASGDGDGGESDSGLPWPLIGGGVAAVLVAGGAGYFLNSGGRGDATGADGGGGSTDGPAADVAAGNGATAAADDAGTESAGQGETGPQDAGADAGAPAAAESTAVDDAANEEMDRPADDDPVDDPNDGSTAEAREGDEGGEAGENETADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W878</accession>
    <name>R4W878_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ORF">L593_02240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445293.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02240"/>
    <dbReference type="EnsemblBacteria" id="AGN00399">
        <property type="protein sequence ID" value="AGN00399"/>
        <property type="gene ID" value="L593_02240"/>
    </dbReference>
    <dbReference type="GeneID" id="16181293"/>
    <dbReference type="KEGG" id="sali:L593_02240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.454"/>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_2"/>
    <dbReference type="OrthoDB" id="1023at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02169">
        <property type="entry name" value="SMC_prok_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="542"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="695"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134636" checksum="F9A9A4B0E422279D" modified="2013-07-24" version="1">MHIQEIVLENFKSFGRKTRIPLYEDFTTISGPNGSGKSNIIDAVLFSLGLARTRGIRARKLTDLIYNPGHEAGADSPGPKEATVEVVLDNGDGKLSRAQVVNAAGTEKVGDVEQIRIRRRVKETEDNYYSYYYLNDRSVNLSDIQDLLAQAGVTPEGYNVVMQGDVTGIINMTSGERREIIDEIAGVAEFDAKKADALEELEVVQERIDEAELRIEEKQERLDQLADERETALEYRDLREEKKEYEGYLKAAELEEKREEREELADEIEAGEADLEELKSDLDERQGRVTRLQEDLEDLNAEIERKGEDEQMELKREVDAIQNSIARLEDKIELAEERIEEAEARRKDAFVKLDRKNEEIDELERQIRETKVEQSSVKSELEERQEALEDVEAKIDAVDTEFEALKDELQTHKQDREELRSEKNELQREQDRLLDQARRRSSEIDEAKAERESLEEQLPELEAERDDLESELRKAEANRENIAEVVDDLQAEKREQQEELDALDDEIQAKQQEYAQLEAQAGDNGDSSYGRAVSTILNADKPGVHGTVAQLGSVEDRYATACETAAGGRLANVVVNDDGVGEECIEYLKAQNAGRATFLPLTEMDKRGLPSAPDDPGVVDFAYNLVDFGGEYEGIFSYVLGDTLVVEDMETARHYMGRFRMVTLDGDLVEKSGAMTGGSTSGSRYSFTKTGKGKLERVAEEINDLQERRSELKSEIRDLEERIDSARDRRSDATEEVQSLQADVDRVEDEMADVREEIEAQEERVAELEDQREAVDQEMNELEESIDEVDGQIADLDEEIEEIESELADSEVPELTAEAEEIEGEIADLEDRMDALDARRNEYELEKGYAEDAIDDLNDEIEQAQATKADQQDEIAEFEDQIEEHEAELEETRKEILALEEELSDLKEDRTELRDTLQEAVDARDELKSELQAARTELDEQRERASTLDAEIEELEAEVDAYDPEDVPDHDEVRRRIGELESEMASLEPVNMKAIEDYDAVEADLEDLQERKDTLVEEREGITDRIESYESQKKDAFMEAFEAIDGHFQRIFERLSNGTGELVLEDEEDPFEGGMTMKAEPADKPVARLEAMSGGEKSLTALSFIFAIQRFDPAPFYALDEIDAFLDAANAERVGEMVDELAGDAQFVVVSHRSAMLERSERAIGVTMQDDNVSAVTGIDLANEGVPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A4</accession>
    <name>R4W8A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445363.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02590"/>
    <dbReference type="EnsemblBacteria" id="AGN00469">
        <property type="protein sequence ID" value="AGN00469"/>
        <property type="gene ID" value="L593_02590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180245"/>
    <dbReference type="KEGG" id="sali:L593_02590"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.525"/>
    <dbReference type="eggNOG" id="arCOG02824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_0_2"/>
    <dbReference type="OrthoDB" id="37310at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="538" mass="57481" checksum="B9DCB1ACE091975A" modified="2013-07-24" version="1">MTRIAGLASNRGRNLINVHERSPGGAELGVVVSNDADAPILEKAADRGIPTAVVEREAGESRSSHEERINDVLADHDYDLVCLDGYMRILTDTFLDAQPTTLNVHPALLPSFPGMDAWSDALDAGVDLTGCTVHVVTDATDEDDEVVEELVDAGPIVTQEPVPVYEGDEEDDLKERVLYEGEFAAYPRAVKWFAEDRVEVDREAGTVSTPGNTDEQLPLRFLATGDRAADLRYGENPHQDAALYADYTCEEATVVGAPQLNEGAKACSYNNYNDADAALGLVKEFDEPAAAVIKHTNPAGAAVADTLADAYRDALSTDAKSAFGGIVALNRECDAETAAEITDSFKEVVVAPGYTDDALDELFEKDNLRVLDVGSLDAPTEQFTEKRLAGGRLVQERDTQAPTAEDLEVVTEAEPTDEQIESMQFAWQTIKHVKSNAILFATGTETVGVGAGQVSRVDAVEIAKMKAENDAEGKSAEGAVMASDAFFPFPDAVEAAAEAGIEAIVQPGGSVNDDDVIAAADEHDVAMVFTGSRAFRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D5</accession>
    <name>R4W8D5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445448.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03015"/>
    <dbReference type="EnsemblBacteria" id="AGN00554">
        <property type="protein sequence ID" value="AGN00554"/>
        <property type="gene ID" value="L593_03015"/>
    </dbReference>
    <dbReference type="GeneID" id="16180463"/>
    <dbReference type="KEGG" id="sali:L593_03015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.611"/>
    <dbReference type="eggNOG" id="arCOG04788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_2_1_2"/>
    <dbReference type="OrthoDB" id="103517at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="7">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="16384" checksum="34B77B0316B4851F" modified="2013-07-24" version="1">MAGSASQRHPLFAPLVILGGLIFGFGLAYSHMARPEVVLDFLQFEDFGLVFVMFGGAAVTGVTYFLAPRLLGQAVLSGDDFERRLKPFDRNVLVGGAIFGVGWGLSGICPGAAYASVGIGNFTILWAIAGMFIGAYAQGVFRSRSPSDEATPASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I6</accession>
    <name>R4W8I6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">L593_03615</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00674.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00674">
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_03615"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="101847at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="24812" checksum="1E3A819AA7E408F1" modified="2013-07-24" version="1">MNVERLRRYEPEPREVTALAALLFAEAALLVGYLQTTQATVTAPRYLVYPFAWINAGVLAIWIVRRRRVSRPSNDAQPPGASRRRIAGVGVAVGYFLALTWIGGAIAFGDVSGVTVHWDLPPGWGPMVIAGLGPIRIAPIPYRIFGYGVLAYLIYVAALDAEATPLSAIVGVFSCVSCTLPVLALILSSTVGGAAGAAASTAYSYDLAVLVYLAALGLLTWRPDVTLLRWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J3</accession>
    <name>R4W8J3_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Trans-aconitate 2-methyltransferase</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_09465</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09465"/>
    <dbReference type="EnsemblBacteria" id="AGN01838">
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        <property type="gene ID" value="L593_09465"/>
    </dbReference>
    <dbReference type="GeneID" id="16182716"/>
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    <dbReference type="eggNOG" id="arCOG04347">
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    </dbReference>
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    <dbReference type="OrthoDB" id="71393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
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    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25974" checksum="B5688E24005E4F16" modified="2013-07-24" version="1">MPFDQTIDWNDYWTDADDADRQDASPSAQYVLDPLRELLADRGGVDSLADVGCGTGTVAFAVAEAYPDATVTGYDAADPVVEENRRRADERDGPTPDFEQATLPSFDPDRRFDVVCSFYTLCYVPRIEQALEALYDAVAPGGTLVLTYHNSLAQSHFQGIAEDPHAHLDESAPWDPERFEDRFAAVLEDEAILSHERIHDVLGTWPQSVWSVTETAERYPAWRHNPLVYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J7</accession>
    <name>R4W8J7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_09540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446747.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09540"/>
    <dbReference type="EnsemblBacteria" id="AGN01853">
        <property type="protein sequence ID" value="AGN01853"/>
        <property type="gene ID" value="L593_09540"/>
    </dbReference>
    <dbReference type="GeneID" id="16182748"/>
    <dbReference type="KEGG" id="sali:L593_09540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1964"/>
    <dbReference type="eggNOG" id="arCOG04549">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551784_0_0_2"/>
    <dbReference type="OrthoDB" id="93632at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="189" mass="19795" checksum="FF03BEB2E6181C65" modified="2013-07-24" version="1">MQLTRRDAVAALAALGSGGAVALGAREWQRSGGDAADDASSGDTVGDGLATDDQVRDAMVAVAEVVYPSDVTGIQTFVERFLAGRLEREGHGEGIRRAVADLDDLARSWYDAPVADLDPADRDALLREVGADVADEVPDGTTAERIRYYVVNDLLLGLYTSPTGGELAGIENPIGHPGGIASYQRGPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L9</accession>
    <name>R4W8L9_9EURY</name>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00729">
        <property type="protein sequence ID" value="AGN00729"/>
        <property type="gene ID" value="L593_03890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03890"/>
    <dbReference type="HOGENOM" id="CLU_1987719_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="13533" checksum="A55956A239B5807B" modified="2013-07-24" version="1">MAPAPSEAARWERVEDAFGALVLALPVLDPVEEDRPEPVLVALVLDVEVDVFALLVDVLELPVDLLALPAEVLVDDRLLLLDVLPVDEEPLVVDVVPELLPDERLDPLSGAHFSGSGRPESRFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P4</accession>
    <name>R4W8P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445693.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04240"/>
    <dbReference type="EnsemblBacteria" id="AGN00799">
        <property type="protein sequence ID" value="AGN00799"/>
        <property type="gene ID" value="L593_04240"/>
    </dbReference>
    <dbReference type="GeneID" id="16180875"/>
    <dbReference type="KEGG" id="sali:L593_04240"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433951_0_0_2"/>
    <dbReference type="OrthoDB" id="116864at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9173" checksum="7903B00D3564D9A9" modified="2013-07-24" version="1">MEVTVYGQLRAVTGQKQVDVDADGRTVRDVLDAFVAAYPRAEPHLFRDDETPHPSVRVAVDGTIVELGDACPADASLSIHPAMQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q4</accession>
    <name>R4W8Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445723.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04390"/>
    <dbReference type="EnsemblBacteria" id="AGN00829">
        <property type="protein sequence ID" value="AGN00829"/>
        <property type="gene ID" value="L593_04390"/>
    </dbReference>
    <dbReference type="GeneID" id="16180924"/>
    <dbReference type="KEGG" id="sali:L593_04390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.893"/>
    <dbReference type="eggNOG" id="arCOG03019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065334_0_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="37618" checksum="2AE93214C1CD8A5D" modified="2013-07-24" version="1">MQVLLIGGTGLISTGITRQLVDEGYDVACFTRGETDAQVPDAVEFVHGDRENPGDLAAARDAVEPDAVIDMFLFHPDRAREAVEVFGGEIEQYVFCSTVDVYHRPLATNPVQEDAPREPAVSEYGANKAAAEDVFMEAHDDGEFATTVIRPWSTYGESGPVLHSLGMGTYYVDRIRKGKPILVHGSGQSLWGPCHRDDVANAFVNAVGNDAAYGEAYHVTSEEVITWDQYHETVAAALDAPEPELVHVPTDQLRAVAPDRTDMLMDHFQFSTVFDNSKARRDLDFEYTVSFEEGVRRTVSWLDEHDEVDAWDSQNDDAIIDAWRDATEEFQAQIDGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q7</accession>
    <name>R4W8Q7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446902.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10315"/>
    <dbReference type="EnsemblBacteria" id="AGN02008">
        <property type="protein sequence ID" value="AGN02008"/>
        <property type="gene ID" value="L593_10315"/>
    </dbReference>
    <dbReference type="GeneID" id="16180969"/>
    <dbReference type="KEGG" id="sali:L593_10315"/>
    <dbReference type="HOGENOM" id="CLU_2748365_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="6995" checksum="6586FBDBB4200A07" modified="2013-07-24" version="1">MNAKSILQSRALGSVAVGLATLLAAVGVQQAASQASETMVLAPLLIAVAFAGIALLAGRASSGGRRTPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W1</accession>
    <name>R4W8W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447027.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10940"/>
    <dbReference type="EnsemblBacteria" id="AGN02133">
        <property type="protein sequence ID" value="AGN02133"/>
        <property type="gene ID" value="L593_10940"/>
    </dbReference>
    <dbReference type="GeneID" id="16181687"/>
    <dbReference type="KEGG" id="sali:L593_10940"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197235_1_0_2"/>
    <dbReference type="OrthoDB" id="130007at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="59" mass="6959" checksum="35FDBD67326CAA77" modified="2013-07-24" version="1">MERVTLRIPKQQIEAVERMVESGEFPNRSEAIRAAVRDKIKDQGEPVHERTRERTWAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X8</accession>
    <name>R4W8X8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="5" type="ORF">L593_11140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447067.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11140"/>
    <dbReference type="EnsemblBacteria" id="AGN02173">
        <property type="protein sequence ID" value="AGN02173"/>
        <property type="gene ID" value="L593_11140"/>
    </dbReference>
    <dbReference type="GeneID" id="16182541"/>
    <dbReference type="KEGG" id="sali:L593_11140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2298"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_2_2"/>
    <dbReference type="OrthoDB" id="125807at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="69" mass="7721" checksum="66F99D401CC16E67" modified="2013-07-24" version="1">MTEIHPVEVRDMTPAEREAELEELQTELLNAKAVQAAGGAPENPGRIKELRRAVARIKTIQREEGDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z5</accession>
    <name>R4W8Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11290"/>
    <dbReference type="EnsemblBacteria" id="AGN02203">
        <property type="protein sequence ID" value="AGN02203"/>
        <property type="gene ID" value="L593_11290"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11290"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="154"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="34920" checksum="AD6BAC33FBD09823" modified="2013-07-24" version="1">MSDLSAGVIGVGSMGRHHARVYHELRDVDLDGVYDVDRERADSIADDYDTEAHDLQSLLETVDLVSIVVPTEYHADLARSAIDAGTALLVEKPIVKDVETGRELVRSAREQDVTLQVGHVERFNPAVRALPDVLADSDVIAVEARRIGPPFDRERGVTSGVVYDLMIHDLDVVRSILDVQAQDVDARAAADGEYVTATVQYDDEVVGTFTASRVTQKKVRELSITTEDSVITVDYMEQSVKINRRSLPEYVETDGDLRYRRENVVERPTVENGEPLKRELSGFVDAVRNGADPVVTGEEGLAVLRTVERIAGAAGRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W906</accession>
    <name>R4W906_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trm1</name>
        <name evidence="9" type="ORF">L593_05775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445998.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05775"/>
    <dbReference type="EnsemblBacteria" id="AGN01104">
        <property type="protein sequence ID" value="AGN01104"/>
        <property type="gene ID" value="L593_05775"/>
    </dbReference>
    <dbReference type="GeneID" id="16181496"/>
    <dbReference type="KEGG" id="sali:L593_05775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1182"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OrthoDB" id="70865at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00290">
        <property type="entry name" value="tRNA_dimethyltr_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022923">
        <property type="entry name" value="TRM1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="40416" checksum="71AB9F87D99F1C57" modified="2013-07-24" version="1">MEVIEGGVRIEVPSTSEEEVGDDVFYNPNQELNRDCTIAVLRAYRERESRASTYCDAMAASGIRGVRAAADGWDVTACDLDPDAIDLCERNFERNGLDADVRQRDANVALHESVHDVVDVDPYGSPIPFADAALSNARDLVCVTATDTAPLCGAHFRAGIRRYSTVPQNTEYHREMGLRVLVSALVRTAARYDRAARPILAHATRHYVRCYLELEGGAGTADDCVDELGHVAHCEDCLHRVAERGFHATVPETCPACGSERVLVAGPIWLGSLRDPEFVAATRAAITPNMGTADRARDLLEEIEGELDQPTHYDQHRLCKAWGRPASGMDEFLDRLRDAGFDATRAHYAGTAFKTDATVEQIRDATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W940</accession>
    <name>R4W940_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-guanine transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446063.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06100"/>
    <dbReference type="EnsemblBacteria" id="AGN01169">
        <property type="protein sequence ID" value="AGN01169"/>
        <property type="gene ID" value="L593_06100"/>
    </dbReference>
    <dbReference type="GeneID" id="16181637"/>
    <dbReference type="KEGG" id="sali:L593_06100"/>
    <dbReference type="eggNOG" id="arCOG00990">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476217_0_0_2"/>
    <dbReference type="OrthoDB" id="40447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="37"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5591" evidence="2">
        <location>
            <begin position="417"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="572" mass="65328" checksum="4C11AFBC8DDACF69" modified="2013-07-24" version="1">MFQTMTFLDYNLTPDNLVEWREKPLKQHFEESDAEPGFTQPLFVDSGGFKLMNSTTFGQPPEEGGSENDWGIYTNPESILKLQLDYGADIVATLDFPIPQNLNKAEATERMKRSIDNAVECLQLLNDDEKLEEWGVDKSPSVYVAIHGHSYEDVNWYVSRFLDRAEELDEAFEGFALGSLVPLSNSPDVLVDIVQGARDAIPEERYDDIALHVFGISGRLCPLLSLLGVDTFDSSNYLKAARNKSFIHPETWQRTKLSDWDEEYCDCQACQNIYFADMRHALLESDVSYKRIEGEHGKRFKSEYYAQIAQHNFELYSRQMQAVRDAIDNDELLELVAEFAQGKNIVEKGLKRAQLHNPELREQLADIGYEELVAGPDAGTFQTKLSGFLEGVEDTTREKRTISLEHGPNDFNILQQDGYQPPSEADVLLILPCSQEKPYSDSRTHQAVLSPIEEYRDQFHKISLSGLYGPVPEEFEEADPVMSYEYVLTTADDDQVELVANRLAQYLDRFGEQFDHILAYTTSKAYRRAIDQAFTRYGRGEIFPSNPRALQLTEHFRGENIDELVERFTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W969</accession>
    <name>R4W969_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12495"/>
    <dbReference type="EnsemblBacteria" id="AGN02438">
        <property type="protein sequence ID" value="AGN02438"/>
        <property type="gene ID" value="L593_12495"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12495"/>
    <dbReference type="HOGENOM" id="CLU_2662530_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="9006" checksum="3EB4F6F16EDA4399" modified="2013-07-24" version="1">MGISNRRLEYEKAKEWGDEMDVFVKEETGNWQDPIISTAEVAQEFEMDEEEVIEHLQDSERVMGREIEEGVWVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B0</accession>
    <name>R4W9B0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lao/ao transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12920"/>
    <dbReference type="EnsemblBacteria" id="AGN02523">
        <property type="protein sequence ID" value="AGN02523"/>
        <property type="gene ID" value="L593_12920"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2649"/>
    <dbReference type="eggNOG" id="arCOG01226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40798" checksum="66EED0F6F867C4A6" modified="2013-07-24" version="1">MTEKSVTDDPAAPAGGRSTEAPAFDVDALVDDLLAGEHRALARAITYIEDRTPGYRELVGALHDHTGDASVVGITGSPGTGKSTLVDKLALEYRDRGHTVGVIAVDPASPFTGGAVLGDRIRMGSTVGDMDVFVRSMSARGALGGLAAATADAVRALDAFGKDRIIIETVGAGQNEIDVVRTADTVAVLVQPGAGDDVQMLKAGILEIADCFVVNKADLDGANRTVQELTEMLQLERDVDPVVRTGHHGVPEADGSTDGEGEEPTADEGDAAAAGDADDATTWRTPVVETIATKGEGVDAVIEAFDDHHEHLEATGALEERARMRYAEEIRTLLREDLGALLEDEIDRRGGIESLAEAVHDRETDPYSVADDLLGPIEDCVEEQRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C9</accession>
    <name>R4W9C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_07210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07210"/>
    <dbReference type="EnsemblBacteria" id="AGN01389">
        <property type="protein sequence ID" value="AGN01389"/>
        <property type="gene ID" value="L593_07210"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1472"/>
    <dbReference type="eggNOG" id="arCOG00626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="49953" checksum="3A7345049D6413B1" modified="2013-07-24" version="1">MHWLSALTTSVSVLQSADLSTSTVTIAGAVSIVVLLGLSAFFSSSEIAMFSLPAHKIDNLVEEGVAGAATLKALKDDPHRLLITILVGNNIVNIAMSSIATGLLAYYVTQGQSVVIATVGITMLVLMFGEAAPKSYAVENTESWALRIARPLKLSEYFLLPMVVVVDYLTRILNRVTGGRSAIESTYVTRSEIKDMIETGERAGVLEEDEHEMLQRIFRFNNTIAKEVMTPRLDMTAVSVDASVDEALTTCVQSGHARVPVYEGSLDNVIGVVHIRDLVRDTQYGENDVDVRDLINPTLHVPESKNADELLSEMRDERVHMVVVIDEFGTTEGLITMEDMVEEIVGEILEGEEDEPIERVDDDTVVVRGEVNIEDVNEAFDVEIPEGEEFETIAGFIFNRAGRLVEAGEEISYENIDIRVERVENTRILEARLHKHEELEASDDEASEEAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D6</accession>
    <name>R4W9D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446303.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07320"/>
    <dbReference type="EnsemblBacteria" id="AGN01409">
        <property type="protein sequence ID" value="AGN01409"/>
        <property type="gene ID" value="L593_07320"/>
    </dbReference>
    <dbReference type="GeneID" id="16182088"/>
    <dbReference type="KEGG" id="sali:L593_07320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1495"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_2"/>
    <dbReference type="OrthoDB" id="18921at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050401">
        <property type="term" value="F:xylonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034624">
        <property type="entry name" value="Xylonate_dehydratase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00564">
        <property type="entry name" value="xylonate_dehydratase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="154"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="44055" checksum="492538EEAB73FE48" modified="2013-07-24" version="1">MTGAERASDVEITDVQTTQVDADWSWTFVRLYTDAGLVGDGECYWGPGIGDVVEHLADRLVGEDPRDVDMLVDRCFESSQHLGSEAGVTASAISGLDLALYDLAGKVIEEPAHRLLGGQYREEARVYADCHAGIHQTAAQRGEGKDAEADLYAPEAYARSAEAAVADGFDALKFDLDADHRFERDQRNRQLDSRAVEYRRQVVEAVDEAVPEDVNVAYDCHWRYDRDSAIRLANAIEPYDVWWLEDVVPPENLDVQRELTRATDTTICAGENRYRTFGVRQLIEEQAVDVLQPDVPKFGGMRESVDAARLADDYYLPVAMHNVSSPLGTVAGAHVAAAIPTFLAIEFHGRDDEHWADFVEEDGIIEDGAIPVPEAPGLGVTLDLDAVEAHMAAGETLLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I6</accession>
    <name>R4W9I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-fructose oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446443.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08020"/>
    <dbReference type="EnsemblBacteria" id="AGN01549">
        <property type="protein sequence ID" value="AGN01549"/>
        <property type="gene ID" value="L593_08020"/>
    </dbReference>
    <dbReference type="GeneID" id="16182287"/>
    <dbReference type="KEGG" id="sali:L593_08020"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_1_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="160"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="39329" checksum="2139E7277F11CBD3" modified="2013-07-24" version="1">MDIADLADDFTARDWQRTEPDPDDPLRFAMIGLGWWTVEEMLPAVAAEPGIETTVLVSSTAEKAERVASETHTDAVGIDYDAFHDGAAAEEYDAAYVCTPNALHLPYVETASELDKAVLCEKPLESTAERAERLVAAAEGIPIMTAYRMHTDPAIRVAKRLYEEGAIGDPVAVQGHMTQDVLYIAGADSWRLNPDLAGPGASVTDLGIYPINTARFVLDREPVAAQATMTSSHEAFEDVPDEVANFLIEYEGDVTGSYTASQHAQLSGSLRIIGTEGELRLEPAFFNDDRARLHYRTGEAGISEQTITFPTVDQMQVEAAYFADCLRDGREIEADAAHGLVDMRAIEAVYEAAERGERVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I8</accession>
    <name>R4W9I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446453.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08070"/>
    <dbReference type="EnsemblBacteria" id="AGN01559">
        <property type="protein sequence ID" value="AGN01559"/>
        <property type="gene ID" value="L593_08070"/>
    </dbReference>
    <dbReference type="GeneID" id="16182298"/>
    <dbReference type="KEGG" id="sali:L593_08070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1654"/>
    <dbReference type="eggNOG" id="arCOG04699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127463_0_0_2"/>
    <dbReference type="OrthoDB" id="106920at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043830">
        <property type="entry name" value="DUF5807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19123">
        <property type="entry name" value="DUF5807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16334" checksum="286E79949120C604" modified="2013-07-24" version="1">MTDARAEFLAGERPDDVALFLSERVLDDPAPLLEYGEEVPGGVLLVMDGETGRSVFQSATEMDAMGFAGKAMKTEGEIARDLTDATCPKADDEETPDPEEHQPRFVFAFAEEENPEVGGRYAEGDVIHAYAHCSCGAAFSQNWVAGERGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q4</accession>
    <name>R4W9Q4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">purD</name>
        <name evidence="12" type="ORF">L593_14770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447782.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14770"/>
    <dbReference type="EnsemblBacteria" id="AGN02888">
        <property type="protein sequence ID" value="AGN02888"/>
        <property type="gene ID" value="L593_14770"/>
    </dbReference>
    <dbReference type="GeneID" id="16181460"/>
    <dbReference type="KEGG" id="sali:L593_14770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3016"/>
    <dbReference type="eggNOG" id="arCOG04415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_0_2"/>
    <dbReference type="OrthoDB" id="58022at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="112"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="440" mass="47336" checksum="E2CC3ED130977959" modified="2013-07-24" version="1">MSETVLLVGGGGREHAIARAVADSDEDVELYAAASNKNPGIAELSSGFVTVDETDADAIVDYATSVGATLAVIGPESALEAGVVDALDDAGIYAFGPREAEARIETDKAYQREFMRENDIPGTPDFQVFDDAEEAAETLRRYEGDMAIKPRGLTGGKGVRVTGDQLTTEEGVEYILESDYEEFVLEERLVGEELTVQAFVANGSVLITPAVQDHKRAYEGDEGPNTGGMGSYTDASFQLPFMTEVDSAEALTILKAVIDELPAYKGILYGQFMLTEDGLKVVEFNARFGDPEAMNTLPALETDFVEILQAARDRQPMPEISFAEKATVVKYAVPEGYPTDPEDGATVTIDDEVVADVSDAYDGEALLFYASVDDRDDGIYTTTSRSYAVVGIADTIAEAEEIAEAALERAGTEGLRVRHDIGKADLVQSRVDHAEELRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U5</accession>
    <name>R4W9U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446708.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09345"/>
    <dbReference type="EnsemblBacteria" id="AGN01814">
        <property type="protein sequence ID" value="AGN01814"/>
        <property type="gene ID" value="L593_09345"/>
    </dbReference>
    <dbReference type="GeneID" id="16180409"/>
    <dbReference type="KEGG" id="sali:L593_09345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1921"/>
    <dbReference type="eggNOG" id="arCOG01134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="41232" checksum="240937C78E9E2FE2" modified="2013-07-24" version="1">MDYDRPLFYHVMAYAAEADRDVIEMVSGSPDWEPPAALRSGLAEYAEAEPDAFQYPPSEGLRGLREEIAARRNVDVERVIITNGAGEANYLAMAGAMDLFEERADGSPSEDPEFLLTDPVYPYYPGKADLLDATKRYVAAEPDGSLDPDAVREQAAASGDDLVAIVVNTPNNPTGAVYDRETVAALAEIAAEHDALLIADEVYDKYDYTGRFESALALDRSNVVVTNAFSKSMAITGFRVGYAILPESMVGGARTRHMLVNVATSRPAQQAVLDALRETGPEYYQRNRQLMADRMATFTDALDAAGADYTEPDGGFYVMARFEDFPGTLENVKRLVDEAGVAGMPGEAFGDARLEWVRFALVTPRVEEAADRLAAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U7</accession>
    <name>R4W9U7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH-domain/beta-lactamase-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446718.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09395"/>
    <dbReference type="EnsemblBacteria" id="AGN01824">
        <property type="protein sequence ID" value="AGN01824"/>
        <property type="gene ID" value="L593_09395"/>
    </dbReference>
    <dbReference type="GeneID" id="16182694"/>
    <dbReference type="KEGG" id="sali:L593_09395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1932"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OrthoDB" id="5321at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="194"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="4">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="642" mass="71961" checksum="289904C267EF8809" modified="2013-07-24" version="1">MSAVEQQLDELKAEIVSELPSHVSVSEVTYEGPELVVYTRDPKEFAQQGDLVRQLASKLRKRITVRPDPDVLLRPEEAREKVMDVIPDDAGVTDLDFHADTGEVVIEAEKPGMVIGRHGSTLREITKEVGWTPEVVRTPPIESSTVSNVRNFLKQERDDRRDILERVGRQIHREELSDDEYVRITTLGCCREVGRAAFVLSTPETRILIDCGDKPGAEGEVPYLQVPEALGAGAQNLDAVVLTHAHLDHSALLPLIFKYGYDGPIYTTEPTRDLMGLLQLDYLDVAAKEGRAPPYESEMVRETIKHTIPLEYGDVTDIAPDVKLTMHNAGHILGSAVSHFHIGDGLYNVCFSGDIHYEDTRLFNGAHNDFPRVETLVLESTYGGRNDYQTDQADSERKLKRIINETYERDGKVLIPAFAVGRSQELMLVLEEAMREGDIPEMPVHLDGMIWEATAIHSTYPEYLRDDLRDRIFHEDENPFLADQFNHIDGGEEERQEVADGGPCIVLSTSGMVEGGPIMSWLRHIGPDPDSTLAFVGYQAQGTLGRRIQNGWDEIPMDDRGHDGGRSNTLQLELEVETVDGFSGHADRQGLVNFVKTMNPRPEKVLCVHGDESSVQDLSSALYHKFDMRTFAPKNLETFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD0</accession>
    <name>R4WAD0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447633.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14000"/>
    <dbReference type="EnsemblBacteria" id="AGN02739">
        <property type="protein sequence ID" value="AGN02739"/>
        <property type="gene ID" value="L593_14000"/>
    </dbReference>
    <dbReference type="GeneID" id="16181003"/>
    <dbReference type="KEGG" id="sali:L593_14000"/>
    <dbReference type="eggNOG" id="arCOG03106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147287_1_1_2"/>
    <dbReference type="OrthoDB" id="106872at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="12426" checksum="DA0489C757B0874D" modified="2013-07-24" version="1">MDAEALARRYYAAIDDGEYDDLREVLAPAFTQVRGDRTFEDRESFVAFMRDDRPETDTTHEIEHVTADGDRVVVEGTLRRANGDVWFRFADAFDVENGRLASLRTYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD5</accession>
    <name>R4WAD5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447658.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14125"/>
    <dbReference type="EnsemblBacteria" id="AGN02764">
        <property type="protein sequence ID" value="AGN02764"/>
        <property type="gene ID" value="L593_14125"/>
    </dbReference>
    <dbReference type="GeneID" id="16181203"/>
    <dbReference type="KEGG" id="sali:L593_14125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2890"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176006_1_0_2"/>
    <dbReference type="OrthoDB" id="129932at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10167" checksum="B761C1FC50559D6A" modified="2013-07-24" version="1">MAGTDDDGLEDLPPSAKLVFKVLEYDGPLTQKQIVEESMLSARTVRYALERLENIGIVEEDIYFADARQNLYSITAEAPSDAEQGVDASATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE2</accession>
    <name>R4WAE2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (pseudouridine(54)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmY</name>
        <name evidence="6" type="ORF">L593_14300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:55292"/>
            <dbReference type="Rhea" id="RHEA-COMP:14140"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="EC" id="2.1.1.257"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. TrmY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.257" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447693.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14300"/>
    <dbReference type="EnsemblBacteria" id="AGN02799">
        <property type="protein sequence ID" value="AGN02799"/>
        <property type="gene ID" value="L593_14300"/>
    </dbReference>
    <dbReference type="GeneID" id="16182031"/>
    <dbReference type="KEGG" id="sali:L593_14300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2927"/>
    <dbReference type="eggNOG" id="arCOG01239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107018_0_0_2"/>
    <dbReference type="OrthoDB" id="126445at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18087">
        <property type="entry name" value="TrmY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00587">
        <property type="entry name" value="tRNA_methyltr_TrmY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40703">
        <property type="entry name" value="PTHR40703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="21416" checksum="5884BDF294F2850B" modified="2013-07-24" version="1">MRQFVVVGHEVTTDAEISLDDLPGAGRFDVLCRAVTATLLTSHGIREDTRVHVVIDDEVTITVDGAHVRRLNPDERSTAALLRGALEERAEAIGHQPVESSPGVELRRRGFQATLDAIVPDGALVVLEADGEAAGAADTPERPVFVLSDHNDFTEDERGILEDRNAKRLSLGPIALHGDQAITVAHNWLDTDGFQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS73</accession>
    <name>R4VS73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00575"/>
    <dbReference type="EnsemblBacteria" id="AGN00070">
        <property type="protein sequence ID" value="AGN00070"/>
        <property type="gene ID" value="L593_00575"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.117"/>
    <dbReference type="eggNOG" id="arCOG00149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654913_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="432" mass="46440" checksum="A0ADF2BBE65094B9" modified="2013-07-24" version="1">MVESEMPDDRPESLRTRRDVLKTTGAASAIATAGLAGCFDNSGDGGDGDGGGSSLEITGVWADAEQEDFSAVMDQVEENSDVSLTYHPRTTDSLLTGTLMDYESGVAPADIVVMPSPARIVSDAQNGHLAPVGDAWSADDFAVEPSRVTVDGEVYAAPFKMDLKPGFWYRQSFFDEHGLSEPGSWEEFQTLLDTISEIDGVDAPIASGNGTGWPLSDITEGFFMRQDNGAELQQGLISGDASFTDDRISSAFEEIKSLHEQGHFSQTRNFGVQYEYFWDGSTPLYFMGSFTPAQDAVQDPSDLGVFRMPGGNGITSSINWLTVPSYSENVDAAVDAIGSLVSADAQQVWVERGGFIASNINVPEDAYQIEVMAQLPQLANEVTVVPDLDDALGNPFQEEFWSQLKGLWASPGTSTSDIVSALDTAHQESLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTZ0</accession>
    <name>R4VTZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03695"/>
    <dbReference type="EnsemblBacteria" id="AGN00690">
        <property type="protein sequence ID" value="AGN00690"/>
        <property type="gene ID" value="L593_03695"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03695"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="274" mass="28477" checksum="38F7019BA8C23648" modified="2013-07-24" version="1">MSADDDGTTMNPETDDERSTERSPSDAGDDDSTLSLREVSFAFGSVTVLEDATLDLDAGTLTALVGPNGSGKTTVLELLAGLRSPNSGSVSRPGGTARSVAYLPQTPQFRSGFTARETLSFYMDLVDDERSPTDLLERVGLEGAADRRVEALSGGMTRLLGVAQALVGDPPVVVLDEPTSGLDPDVADHIFATVEAIARDGRTVVIASHDLEAIEETADRVVTLVDGRFVQDGAPADVVEATGASTLRAAFSDAVQGAERKAVQLDAPPTGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUI0</accession>
    <name>R4VUI0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445764.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04605"/>
    <dbReference type="EnsemblBacteria" id="AGN00870">
        <property type="protein sequence ID" value="AGN00870"/>
        <property type="gene ID" value="L593_04605"/>
    </dbReference>
    <dbReference type="GeneID" id="16181009"/>
    <dbReference type="KEGG" id="sali:L593_04605"/>
    <dbReference type="eggNOG" id="arCOG08980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159738_4_0_2"/>
    <dbReference type="OrthoDB" id="108364at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12567" checksum="1C9954A6191AC6FC" modified="2013-07-24" version="1">MAVTASGIEVEAVEYSQDSVTVRTQFDHEKTPASMAVIATLADVLDTDPAALEPLHSTVDTDALDALVRVRPESNGDTQVALSHEGYSITVHSHGVITITPEHERTAAYHGGGRDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUJ8</accession>
    <name>R4VUJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04705"/>
    <dbReference type="TCDB" id="2.A.58.1.9">
        <property type="family name" value="the phosphate:na(+) symporter (pnas) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00890">
        <property type="protein sequence ID" value="AGN00890"/>
        <property type="gene ID" value="L593_04705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.961"/>
    <dbReference type="eggNOG" id="arCOG00233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737107_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="370" mass="39155" checksum="967C467361D7039D" modified="2013-07-24" version="1">MTDSDELTEASTTRRRNRLLAIGPLWLGAITSILLFLFGIQLLGAATEAASPTIARIHDQIVVGGGSALGISWLVTYGLTSGSVVAALAVSLLSSGIVSTSGAFMMIVGSRIGAGAIVVLIGGLDYAQEGQIRSMRESMSLGLLTFLIALTVYVPTAIVGIVVLATFRSELFEATRGLDLPLGALEFFGPAVDAVTRAIGPRSALVVAIASLFAGLWLFDTVLERVDTETVRRHVFRHFGHVWTAFVVGLVITAVTTSVAFSLGVVVPLYNREFVKREEITPYVLGANVGTLLDTLAVAFVLETPAGVAVVLLVMGIATALTALLLVAYDPYVSAIHAVQNRLLTDRRFFVGFLLVLVVVPVTLVVLPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUP3</accession>
    <name>R4VUP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445839.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04980"/>
    <dbReference type="EnsemblBacteria" id="AGN00945">
        <property type="protein sequence ID" value="AGN00945"/>
        <property type="gene ID" value="L593_04980"/>
    </dbReference>
    <dbReference type="GeneID" id="16181223"/>
    <dbReference type="KEGG" id="sali:L593_04980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1014"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="39077" checksum="E1199768BA552523" modified="2013-07-24" version="1">MTSLDSVLVTGGAGFVGSHAVEYYADRGVEVTALDNLSRVETLETADDSRNTAAYNWEYIREEYPSVELVEADVRDEDRLETIVEGHDGIVHTAGQVAVTASLEDPRTDFEVNAEGTFNVLEAARAAESDPAVVMASTNKVYGDNVNEIPVREEETRYWYDDPEYEDGVPETLSIDDCEHTPYGVSKLAGDLYVQDYADRGVVEAAAFRMSCIYGPRQFGNEDQGWVAHFAISALRDEPLTIFGDGKQVRDVLYVDDLIRAYDAFLSDPDGKPAIYNVGGGPHNTTSLVEFLDALESVVGNRPDVAFDDWREGDQKVYVSDVSRACNELDWSPDVDFEEGIERFVDWWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUP7</accession>
    <name>R4VUP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal-transducing histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444880.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00155"/>
    <dbReference type="EnsemblBacteria" id="AGM99985">
        <property type="protein sequence ID" value="AGM99985"/>
        <property type="gene ID" value="L593_00155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180960"/>
    <dbReference type="KEGG" id="sali:L593_00155"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA" evidence="1">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="38861" checksum="5E02C66DF03065C1" modified="2013-07-24" version="1">MSDAGSDGRQYSDRSLAFGASAALFEYAPQPMAAVQGSETPSIQVVNRSYLEQFDGRRVDERDARSFRRRTALSDPERAVVRTAASGSVGCDTVAKRTADGHRQFQVRAIPAPRSDVTAYLQYRDVTARQIRDQQLAVLRRVLRHDLRNDLTVMLGYAQSIAESSDDPESRRDAETIVEAARDLRTVADSAGRMQCVTAPARSKSLREIATTVRRSIVPAFSGRFDVDGTIPPITVDNRIEVALEELCQTVEEHGDATTLELAADEGDDWATITLETNGTLCEQERSALEGRDETQLRHATGIAPWIARWAVRAAGGRLRLDRLDGGGCRIVILVPTIDPATESTTRSASWSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUS1</accession>
    <name>R4VUS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444905.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00280"/>
    <dbReference type="EnsemblBacteria" id="AGN00011">
        <property type="protein sequence ID" value="AGN00011"/>
        <property type="gene ID" value="L593_00280"/>
    </dbReference>
    <dbReference type="GeneID" id="16182466"/>
    <dbReference type="KEGG" id="sali:L593_00280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.56"/>
    <dbReference type="eggNOG" id="arCOG04604">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_1_2"/>
    <dbReference type="OrthoDB" id="63011at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="160" mass="18287" checksum="743B4D721409851B" modified="2013-07-24" version="1">MAVYERTTRVRAPFEEVWEFHATTDGLVALTPNWLGLKVEEVTGPDGEPDPAELVEGSEIQLSLRPFGVGPRRRTKSVIVERREQDGTAFFRDRMVEGPFSEWLHTHAFYAGEDDTIVRDRVEYELPGGAPGRLAARAMVVGMAPMFRYRHRRTRELLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUX4</accession>
    <name>R4VUX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05430"/>
    <dbReference type="EnsemblBacteria" id="AGN01035">
        <property type="protein sequence ID" value="AGN01035"/>
        <property type="gene ID" value="L593_05430"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1109"/>
    <dbReference type="eggNOG" id="arCOG01576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_2"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="769" mass="80802" checksum="CFD71923AC5F42E9" modified="2013-07-24" version="1">MDDHERESAVGPSQDHSRHGAGEPAEDTPREQSMLENQARHAGAGRQGQHDQGGPGGDGGHGDRGSHGDAGDHGGHGGMHEGHEQLFRRRFFVATLLSIPVLLYSETLQGWLGFSAPAFPGSEWISPVFSVIVFAVGGVPFLRMAVPELRDRAPGMMTLISMAISVAFVYSLATVAVDWGEPFFWELVTLIDVMLLGHWIEMRSVRRASSALDELAKLMPDTAERIVESGETEEVPVHQLSEGDLVLVRPGASVPADGVVEEGDSDVNEAMITGESRPVSKTPGDEVIGGTVNGDGSLRVRVDAIGEDTTLAGIMRLVESAQQSKSRTQVLADRAAGWLFYVAVAAAAVTGVAWTVAVTFDAEVIARVVTVLVIACPHALGLAIPLVVAINTSLAARNGMLIRDRIAMEDARNLDSIVFDKTGTLTEGEHGVVGTATVEGVDADEALALAAAVEGDSEHVIARAIREAASERGVDVPESRAFEAIKGRGVRALVGGEELYVGGPNLLHQLESGVLPELQSFADEAGENAQTVVYLVRGAERMEVPEGGSGDDGPASREGELLAAFAMADVIREESYAVVDALHELGIEVAMLTGDSRDVADAVADELGIDTVFAEVLPEDKDVKIQELQDQGNRVGMVGDGVNDAPALTRADVGIAIGSGTDVAVQSADVILVQNNPMDVVRLVKLSKASYRKMQENIVWAAGYNVFAIPLAAGVLAPIGVVLSPAVGAVLMSLSTVIVAINAQLLRRVDLSVPGPLGVSARGRTSPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVP9</accession>
    <name>R4VVP9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mevalonate kinase</fullName>
            <shortName evidence="5">MK</shortName>
            <shortName evidence="5">MVK</shortName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mvk</name>
        <name evidence="8" type="ORF">L593_01900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445225.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01900"/>
    <dbReference type="EnsemblBacteria" id="AGN00331">
        <property type="protein sequence ID" value="AGN00331"/>
        <property type="gene ID" value="L593_01900"/>
    </dbReference>
    <dbReference type="GeneID" id="16179829"/>
    <dbReference type="KEGG" id="sali:L593_01900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.386"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OrthoDB" id="90882at2157"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="33825" checksum="C09D5E516D7191D3" modified="2013-07-24" version="1">MATSSAPGKVFLLGEHAVVYGEPALLAAIERRARVTVEERSDGGLRVDSEDLTLDGFTIEYGEDAATDPNVDVPQNLLEAATGYVDEAVAQARDAADAPNAGFEVTIESEIPLGAGIGSSAAVVAAAIDAATRELGVELDREEIADRAYRVEHAVQDGQASRADTFTSTMGGVVRVEGDGGHSIPAPELPLVIGYDGGAGDTGKLVADVRSLRERYGFAADTVETIGDVVDEGERALDDGDVETLGELMNADHGLLSALGVSSRSLDAMVWAARDAGAMGAKLTGAGGGGCIVALDESDESQTALEYTPGCEEAFRAELAEEGVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVV0</accession>
    <name>R4VVV0_9EURY</name>
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        <submittedName>
            <fullName evidence="6">ABC-type transport system involved in Fe-S cluster assembly, ATPase component</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">L593_02175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02175"/>
    <dbReference type="EnsemblBacteria" id="AGN00386">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33832" checksum="8E7CBC5B6E55A261" modified="2013-07-24" version="1">MARLELSQLEARVAEEDGEVILEGVDLEVEAGEIHALMGPNGSGKSTTAKVIAGHPAYEVTGGEVLLHLEEGDFGGDVEIPEDKQTWNLLELEPNERAALGVFLGFQYPAEIEGVTMANFLRTALNAKLEEREELFEDEDEEAEADDEGEDDEGYETSPMEGPADEGDVGVAEFQQILQEKMELLDMDESFAQRYLNAGFSGGEKKQNEVLQAAILEPEIAVLDEIDSGLDIDRLQDVSDGINALRDEQGTGVLQITHYQRILDYVEPDRVHVMLDGKIAMSGGPELAEKLEDKGYDWVREEVYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVY7</accession>
    <name>R4VVY7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_07140</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07140"/>
    <dbReference type="EnsemblBacteria" id="AGN01375">
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        <property type="gene ID" value="L593_07140"/>
    </dbReference>
    <dbReference type="GeneID" id="16182257"/>
    <dbReference type="KEGG" id="sali:L593_07140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1459"/>
    <dbReference type="eggNOG" id="arCOG04666">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120318_0_0_2"/>
    <dbReference type="OrthoDB" id="83653at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="24972" checksum="2B66018F27D8F4DE" modified="2013-07-24" version="1">MEETPTGTPVGVDDPYEHVDRCDHCTDEGTCRFAFERFTDDPTFAEERRDDEFRCPVVNPDADREWESAECPNFRSTTDGKECRRCGIEERRMAHSHDRPLIEEHHLSYAENEARSASEQSSIAERSSADHSSGQSPREDGDGGEPRDGEAPEGEDDPNGGDHEITVALCRWCHTKVHKSWARIDDDVSPDPEAIAAREERRGKEFEEASFETAAERFGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW43</accession>
    <name>R4VW43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00486">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="12871" checksum="85DEFC0EC7E67265" modified="2013-07-24" version="1">MAIYGSFTVGIVALLAGVGIGFDLVGAIGYFLGVTVGGALCVYACVLGSVTISDERFAAIERRASHYTLLGLAYAGLATFPALFVLEAAGRFAFSEALETLLFAFSALFLVWGAVYTALRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW88</accession>
    <name>R4VW88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KEOPS complex Pcc1-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445430.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02925"/>
    <dbReference type="EnsemblBacteria" id="AGN00536">
        <property type="protein sequence ID" value="AGN00536"/>
        <property type="gene ID" value="L593_02925"/>
    </dbReference>
    <dbReference type="GeneID" id="16180379"/>
    <dbReference type="KEGG" id="sali:L593_02925"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170076_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8534" checksum="3197B4A74DD60651" modified="2013-07-24" version="1">MAIRATLEFSYADSALAQSIERAISLDAGAIEGDRSATAVTRDDDTVIVEIDAADPKALRAAKRTWCSHVAAAEETAIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWG9</accession>
    <name>R4VWG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446484.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01590">
        <property type="protein sequence ID" value="AGN01590"/>
        <property type="gene ID" value="L593_08225"/>
    </dbReference>
    <dbReference type="GeneID" id="16182447"/>
    <dbReference type="KEGG" id="sali:L593_08225"/>
    <dbReference type="HOGENOM" id="CLU_2597905_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="9140" checksum="C584070851BEC7C3" modified="2013-07-24" version="1">MTYSLGSDEEMAEAVINAFHAANIDVFDKPTELDDWVSTDIFETLHWTDRPVFLSTRIWDQRVVLCAEEVRIYTTGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWY5</accession>
    <name>R4VWY5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif1a</name>
        <name evidence="8" type="ORF">L593_08875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446614.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08875"/>
    <dbReference type="EnsemblBacteria" id="AGN01720">
        <property type="protein sequence ID" value="AGN01720"/>
        <property type="gene ID" value="L593_08875"/>
    </dbReference>
    <dbReference type="GeneID" id="16182685"/>
    <dbReference type="KEGG" id="sali:L593_08875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1820"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OrthoDB" id="102432at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="97" mass="11286" checksum="3AF89F1A9D280E0F" modified="2013-07-24" version="1">MSDEDGPASVEDIRMPDDDEVFAEVLEMLGANRVRVRCADGVERTARIPGKMQKRIWIREDDVVLVEPWDWQDEKGDISWRYEKSQAETLREEGYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX61</accession>
    <name>R4VX61_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxT</name>
        <name evidence="4" type="ORF">L593_04500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04500"/>
    <dbReference type="EnsemblBacteria" id="AGN00851">
        <property type="protein sequence ID" value="AGN00851"/>
        <property type="gene ID" value="L593_04500"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.917"/>
    <dbReference type="eggNOG" id="arCOG00034">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="21149" checksum="63103B254E7A3DF5" modified="2013-07-24" version="1">MTIRAGVIAVQGDVAEHVAAVEQAGERLGQDVDVVEIRDAGVVPDCDVLLMPGGESTTISRTLQREGIAPEIEAHADADKPIFATCAGLIVCSRDPQDDRVQELGLLDVAVERNAFGRQKHSFEAAIDVTGLDEPFPAVFIRAPAIDDVGEDVEVLATVQGRPVAVRQGAIVGTAFHPELTDDARLHDLALFEPLAAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX79</accession>
    <name>R4VX79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain alpha-keto acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446729.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09450"/>
    <dbReference type="EnsemblBacteria" id="AGN01835">
        <property type="protein sequence ID" value="AGN01835"/>
        <property type="gene ID" value="L593_09450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180318"/>
    <dbReference type="KEGG" id="sali:L593_09450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1945"/>
    <dbReference type="eggNOG" id="arCOG02700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_2"/>
    <dbReference type="OrthoDB" id="74660at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="4">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="575" mass="60021" checksum="7B3651437341622D" modified="2013-07-24" version="1">MPREFKLPDVGEGVHEGELVEWLVEPGDTVAEDQPVAKVETDKALVDVPSSVNGTVRELRWEEGDVVPVGDVLLVFNVEGEDDEAIAAGETEGGETEGGEASGSAAESAGGGAAADAGESGGEPAQPEAESPPPAGSPEAAEAASASDSGRVFAAPSARRIARELGVNIHAVEGSGPGGRVTEQDVRAAAEAAEEPAAAEGDAGTAETPEVSLESEEGAAGGIEAAVDAGMEGDAGTTGQTGPAATQQTAEPEAAADRDRTLAAPATRRLAEEQGVDLDAVPATEERDGEPFVTPEAVVEYAEAQQQAQAADAEAVEAGGPSGATEAAGTAQPPASQERSERREPYRGVRRTIGEAMAESKYTAPHVTHHDEVDVTELVDVKQRLAERAEERGIKLTYMPFVLKAVTAALKEYPVMNAALDEDAGEIVYKEYYDLGIATATDVGLMVPVLQGVDRKGLLQLASEMDELVEKARERTIAPEELRGSTFSVTNVGAIGGEYATPILNYPEVGILALGQIRRKPRVVEDEDGNESIEPRSILPLSLSIDHRIVDGAIAAQFTNEVMQYLENPELLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXA1</accession>
    <name>R4VXA1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_04710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445785.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04710"/>
    <dbReference type="EnsemblBacteria" id="AGN00891">
        <property type="protein sequence ID" value="AGN00891"/>
        <property type="gene ID" value="L593_04710"/>
    </dbReference>
    <dbReference type="GeneID" id="16180950"/>
    <dbReference type="KEGG" id="sali:L593_04710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.963"/>
    <dbReference type="eggNOG" id="arCOG01482">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_2_0_2"/>
    <dbReference type="OrthoDB" id="73201at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="7">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="29250" checksum="06F4EBE5DE71F7AA" modified="2013-07-24" version="1">MLDRTTIEGWLREDLGHHDVTNDVPGETTGRLVAKETGVAAGIDAAEAVFSYLDVEVTERVDEGTELDAGDVALRVEGSAQDVLRAERTAVNIAGHASGIATKTAAAVEAAQTAGLGFDLDAGAAGDTPAIAGTRKTTPGLRGVEKRAIVAGGGDTHRLDLSHMVMVKDNHVAEMGMESAIEHFEEKASFATKIEVEVESPEDAPRAAEAGADIVLLDNMEPAAVERAVELVDESDADALLEASGGITVETVPDYATTGVDVLSLGSLTHSASSLDFSFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXH1</accession>
    <name>R4VXH1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylglyoxal synthase</fullName>
            <shortName evidence="2">MGS</shortName>
            <ecNumber evidence="2">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mgsA</name>
        <name evidence="4" type="ORF">L593_05035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445850.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05035"/>
    <dbReference type="EnsemblBacteria" id="AGN00956">
        <property type="protein sequence ID" value="AGN00956"/>
        <property type="gene ID" value="L593_05035"/>
    </dbReference>
    <dbReference type="GeneID" id="16181257"/>
    <dbReference type="KEGG" id="sali:L593_05035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1026"/>
    <dbReference type="eggNOG" id="arCOG06314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_1_0_2"/>
    <dbReference type="OrthoDB" id="99337at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13246" checksum="50AC3213557DE2BF" modified="2013-07-24" version="1">MARIALIAHDEEKPAIIAFAERHSDALAECELVCTGTTGKRIQEETGLDVERKQSGPLGGDLQIGAEVADDELDAICFFRDPLTAQPHEPDISALLRICDVHDTPLATNDASAELLLEGLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXR2</accession>
    <name>R4VXR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445945.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05510"/>
    <dbReference type="EnsemblBacteria" id="AGN01051">
        <property type="protein sequence ID" value="AGN01051"/>
        <property type="gene ID" value="L593_05510"/>
    </dbReference>
    <dbReference type="GeneID" id="16180050"/>
    <dbReference type="KEGG" id="sali:L593_05510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1126"/>
    <dbReference type="eggNOG" id="arCOG01470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066801_0_0_2"/>
    <dbReference type="OrthoDB" id="75436at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="37484" checksum="5C5F5ACCC9E8B7C7" modified="2013-07-24" version="1">MSRDPRLTIARRELAALKSEKTIVLALLIQLFVAGFSSFLVVGLVSMYDPSSVEGGSVGVAIVGEGDEDVADSLESVDGVEPTSFADVTEAHTRFRDGRFDALLVVTESEDGRLRIRASVPDSGVRSTLVVVRLREGLQQVERDRRASFSDRLDFEPIALPESSAGSPYVGFTYTVLVPLLCFLPVFISGSIAVDSISEELERGTFELLRAAPVSLVDILDGKLLAAGSLAPLQAALWLALLRFNGIPIEHALPVVGLVAALTAAIVGLGIAIALLAPDRRQAQLVYSVGVLSVFVVASLLPEHPANTVAKLAIGNPTDATWTLLAGYLVAGASALVVVRGLVGRLSVEHLGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXT6</accession>
    <name>R4VXT6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446974.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10675"/>
    <dbReference type="EnsemblBacteria" id="AGN02080">
        <property type="protein sequence ID" value="AGN02080"/>
        <property type="gene ID" value="L593_10675"/>
    </dbReference>
    <dbReference type="GeneID" id="16182043"/>
    <dbReference type="KEGG" id="sali:L593_10675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2201"/>
    <dbReference type="eggNOG" id="arCOG01336">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_0_2"/>
    <dbReference type="OrthoDB" id="107157at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="21741" checksum="B5734C82C89AD73A" modified="2013-07-24" version="1">MADAQTVDLTYEDGARAVELAREAVELYVRNGQREQPGSMRDAFYQRTGAFVRLESTRGRGSLRGCAGGYEASERLGHVIVDAAIEAASGDSAGSEVSPPELSNLTVSVCAVTNVLLTDDPLADLELGTHGVAVDGGAEHGWLYPTVPLEQRWTEEEYLQRTCRKAGLPPNAWQQEDVVVTLFEGEVFREREAEGSVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY01</accession>
    <name>R4VY01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447039.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11000"/>
    <dbReference type="EnsemblBacteria" id="AGN02145">
        <property type="protein sequence ID" value="AGN02145"/>
        <property type="gene ID" value="L593_11000"/>
    </dbReference>
    <dbReference type="GeneID" id="16181936"/>
    <dbReference type="KEGG" id="sali:L593_11000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2268"/>
    <dbReference type="eggNOG" id="arCOG01902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_2"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="26299" checksum="038C4A586E7C1882" modified="2013-07-24" version="1">MARTAIQLYTLREVDSSLDDLLEMVAAAGFDAVEFAGRETKYEPDEVVDMLARNGLEVAGAHVGIEDLEDDPDGLAERYEAMDCTNLICPGMDPRHFESQEGVATAAGRLEVVADALEDTDCTLHYHTHTQEFQQIEGGLAFEGFLAATDVSIELDVGHTLRAGEDPADWLRRLEGRAELVHFADVDVESDESVPLGEGDVDLAACAEAAAEIGADWYVYEYEGADPLTTIDDAAQKLMNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYF1</accession>
    <name>R4VYF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446145.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06520"/>
    <dbReference type="EnsemblBacteria" id="AGN01251">
        <property type="protein sequence ID" value="AGN01251"/>
        <property type="gene ID" value="L593_06520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180863"/>
    <dbReference type="KEGG" id="sali:L593_06520"/>
    <dbReference type="eggNOG" id="arCOG01900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863048_0_0_2"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="36242" checksum="F3D6BEF8622829E0" modified="2013-07-24" version="1">MKLGLLTVSYSGLWHDGPGLSIEEQIERADELGYDAISIETKRPTAFPLDFDADDRQRIRETADEAGIEICAVESMSNFASEFHEERENNLAMMHDVLEFADDLGVDLVKVFPAWPGIKDDQAETAIYGEIPMRAHWEQQYPGTEQYAKWSRCVEGIREVADWAAEMDITLALQNHPPVLAGGYEDALQMVQEIDRDNVGLCLDAVLFYERQSDEYVREAVEACAEHIELSHYGAWNFAREDGEVVQTPSPLSGELINNEAFVRALDDVGYDGYLVSEYCVPVMEDHEVQGIEAIDEANEMSLGYMQEILEDVESEGAVAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYI1</accession>
    <name>R4VYI1_9EURY</name>
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        <submittedName>
            <fullName evidence="6">Amino acid/amide ABC transporter ATP-binding protein 1, haat family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446180.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06695"/>
    <dbReference type="EnsemblBacteria" id="AGN01286">
        <property type="protein sequence ID" value="AGN01286"/>
        <property type="gene ID" value="L593_06695"/>
    </dbReference>
    <dbReference type="GeneID" id="16181839"/>
    <dbReference type="KEGG" id="sali:L593_06695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1367"/>
    <dbReference type="eggNOG" id="arCOG00926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="58905at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="34588" checksum="D621E8A0B99E7B7F" modified="2013-07-24" version="1">MTLLRTRGLTKRFGGLTAVDGVDFGLGADECVSLIGPNGAGKTTFFNLLTGSLAPTEGTVEYRPGGGRAVADGRGDAGGTVSSDRKPIADGGAVADQGSGSPGEDAGAGGWQDVTDASPDETARLGIHRSYQITNIFPASTVLENVRIAAQAHGGADSWRLWRNVGAFGEYEEEAWRILERVGLDDRAELVADTLSHGQKRHLEVAIALAGDPDVLLMDEPTAGVSRDGVDRIVSLIDDVAADHAILLVEHNMDVVMDVSDRIAVLHQGSLIADDEPEAVRNDPAVQRAYLGGYEENGGEGDRTGEAGSTATQSKPATDGTGRTTDDGGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYT1</accession>
    <name>R4VYT1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin / Dps domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447314.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12405"/>
    <dbReference type="EnsemblBacteria" id="AGN02420">
        <property type="protein sequence ID" value="AGN02420"/>
        <property type="gene ID" value="L593_12405"/>
    </dbReference>
    <dbReference type="GeneID" id="16179924"/>
    <dbReference type="KEGG" id="sali:L593_12405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2551"/>
    <dbReference type="eggNOG" id="arCOG01093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OrthoDB" id="86510at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16979" checksum="7C5CC4F135A3FBBF" modified="2013-07-24" version="1">MSSDRVVELLRKAYGDEMETVMNYQTNAIVLDGVRAEEIKESLQADIQEELGHAQQLGQRLKQLDARPPSSADFVAHQETLQPPDDSTDVLSVIRGVLDAEEDAIDTYRDLIDAAEDADDPVTEDLAVTILADEEAHRTEFRGFEKEYAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYV5</accession>
    <name>R4VYV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MaoC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12530"/>
    <dbReference type="EnsemblBacteria" id="AGN02445">
        <property type="protein sequence ID" value="AGN02445"/>
        <property type="gene ID" value="L593_12530"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2572"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00778">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890284_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="31802" checksum="F05511EFFACAC31F" modified="2013-07-24" version="1">MLTVSVRDVMVEDVATIRPDGTLHEAADRMAARDVGSLVVVEDDEVVGILTHSDVLRHIASDGDPTSATVAASMGSPPITIEPTADAEDAATLLSTEDVKRLPVVEDGDLVGVVTVTDLSYVLPQIALGRPEGRSRPATRPEMAYDDEEWAADLQTGDDPDVGDTVRFTKRISEGDVEDFARATGDTNRLHLDDGFAIGTRFGERIVHGTLVAGVISAALARLPGLTIYLSQDLGFRAPVPIGATVTAACEITEALGGNRYRVSTTVYHENEPVVDGQATVLIDQLHEAPALGRAAVGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ26</accession>
    <name>R4VZ26_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_12905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447414.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12905"/>
    <dbReference type="EnsemblBacteria" id="AGN02520">
        <property type="protein sequence ID" value="AGN02520"/>
        <property type="gene ID" value="L593_12905"/>
    </dbReference>
    <dbReference type="GeneID" id="16180241"/>
    <dbReference type="KEGG" id="sali:L593_12905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2646"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_2"/>
    <dbReference type="OrthoDB" id="2789at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="720" mass="75909" checksum="60E8106BEEA36083" modified="2013-07-24" version="1">MGRLSGLFAPSSIAVVGATDREGSVGRAIIENLDADYDGDVVAVNPYRGSVLGHTCYDDLEEAPYVDLAVVVVPPDAAIETVRSAGEVGIKNVVVITAGFGETGSEGATREQELQAVAEEYDLNVVGPNSLGIMSTPVGMNATFGPDNALDGSISFMSQSGAFVTAVLDWAIQQDIGFKDVVSLGNKAVLDETDFVEAWGEDDDTDVIVGYLEGIDRGREFIETAREANDDTPMVLVKSGRTEAGAQAASSHTGTMAGAEAAYEAGLEQAGVLRVDTVQELFDAARALSGLPELPKDDVAVVTNAGGPGVMATDAVGDSSLNLASFSDATLESFDELLPDEATGYNPVDVIGDADVARFRGALDIALNDDGVGAAIVLAAPTAVLSYEELADAVGELQAEYGKPVVGAFMGGESAERGAAALREHGIPNYFDPARAVDSLEALSRYREISERTYPEHETFEDVDRERAREILGRVEERSDNRLGVEAMDLLDAYGIPTPDGEVVDSPAEAESVAADIEGDVVMKIVSPDILHKSDIGGVRVGVEQADVRDAYEDLVARAHNYQPDADVLGVQVQAMVDLDDATETIIGANRDPQFGPLLLFGLGGIFVEVLEDTSLRVGPISEPEARTMVDEIKAAPLLRGARGREPADVDAVVEALQRLSQLVWEFPAILELDVNPLVAGPDGANAIDVRLTVDPDQLADEPRTDAPSTTDHSTPSPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZA3</accession>
    <name>R4VZA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447499.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13330"/>
    <dbReference type="EnsemblBacteria" id="AGN02605">
        <property type="protein sequence ID" value="AGN02605"/>
        <property type="gene ID" value="L593_13330"/>
    </dbReference>
    <dbReference type="GeneID" id="16182378"/>
    <dbReference type="KEGG" id="sali:L593_13330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2727"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_14_1_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22816" checksum="52CE1823838B6EBF" modified="2013-07-24" version="1">MSTVAPFEEHTDRYDGWFEDHEHAYRSELAALDRLVPATGHGVEIGVGTGRFAAPLGIQVGLDPSRKMLERARERGIDVVQGVAEALPFANGTFDTALLVTTICFVDDVAQTFSEAARILDPDGALVIGFIDANSPVGRIYREKQEQNPFYRDATFVTTAELVEALRTAGFGDLTFVQTIYEWPGEIDEPEPVESGYGEGSFVGIEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZQ8</accession>
    <name>R4VZQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kef-type transporter NAD-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_13980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447629.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13980"/>
    <dbReference type="EnsemblBacteria" id="AGN02735">
        <property type="protein sequence ID" value="AGN02735"/>
        <property type="gene ID" value="L593_13980"/>
    </dbReference>
    <dbReference type="GeneID" id="16180986"/>
    <dbReference type="KEGG" id="sali:L593_13980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2860"/>
    <dbReference type="eggNOG" id="arCOG01958">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057267_1_0_2"/>
    <dbReference type="OrthoDB" id="59289at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="238"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="39974" checksum="0EA5A5CD3586FDD8" modified="2013-07-24" version="1">MFGAWTGKRLSVLLAVIVGVLSVLTGIANVGIGAIAVVGPLEPYVPETVRLVAGFSGAISGFLVLLAALGLRRGYRAAWILTIVLLPITAAQGLIQSSPLSLPLVVFSLLSMPTLVLSRHHFRSPLSLSTAQIAAGLALVGVQLYGTVGTYALREEFSGVSTVLDAFYFTLVTASTVGYGDVTPTTQVARLFTMSVLVFGTATFAIALGTLLAPILESRFAAALGRVRNREFDLLEDHVLVLGHGDLTEPIVDALKDRDRQFVVATRQAQTATELAERDVLALHADPSDHATLERANLDEATAVVAATSSDSADAFSVLTARQLDPEIRIVAAATNAENTSKLRRAGADVVVNPAVIGGQLLVGTIADRGDDGLDGIDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW3</accession>
    <name>R4VZW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447689.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14280"/>
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            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7500" checksum="870F7D9B523BC71B" modified="2013-07-24" version="1">MTDDTDDADDQNDSAGQADVPTDAVDDAPRTHEYVWRCTGCKARYDERPDRCEHCGATEFTKFRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W068</accession>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
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            <end position="131"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="19262" checksum="00B324416897A086" modified="2013-07-24" version="1">MSEVERDGPPRSRSVVVGAVKYAVVEGDSRVFRSYAVIGSLLAILVGLMFVLALPVWVMEIAESGGGTLDRVGLGLLWLVGLAVIATMVVPMLLVVRRHRQGRPERQLAFGLAGFAYVLSIYLALLVSAPADLRDDPDGVLEPVLGPVLEALYGLPRLSGLLFPVVGTLLLVAIEYGLDR</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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    </dbReference>
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            <dbReference type="EMBL" id="AGN01961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="6864" checksum="3CA912FEB592CD66" modified="2013-07-24" version="1">MNEAYVRLLCPECKKEWESTPSGLPAHDTVFHCPNCHNSRRLAEFARTDRDLETMKSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0H0</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13898" checksum="896215A566033094" modified="2013-07-24" version="1">MGRTRATTRDRLDALEREWMPFRRSLRRRHQPAFDRLFEHARGHAEAATQQNPADPWRGFVFAVLLAQEQATAAREEEIAALEEKLADREAEVERLAADVDALHERVAELAGESVAADPEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0H3</accession>
    <name>R4W0H3_9EURY</name>
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    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02016">
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        <property type="gene ID" value="L593_10355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10355"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="52" mass="5889" checksum="E75F1A7F0CD37517" modified="2013-07-24" version="1">MPECQNCGSFVTEAYARVFTPRGVDEPRVCPECEDKIRDGSDVREARSPRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
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    <name>R4W0N8_9EURY</name>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447005.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10830"/>
    <dbReference type="EnsemblBacteria" id="AGN02111">
        <property type="protein sequence ID" value="AGN02111"/>
        <property type="gene ID" value="L593_10830"/>
    </dbReference>
    <dbReference type="GeneID" id="16180043"/>
    <dbReference type="KEGG" id="sali:L593_10830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2235"/>
    <dbReference type="eggNOG" id="arCOG03060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_2"/>
    <dbReference type="OrthoDB" id="10764at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="651" mass="69638" checksum="A2D46A8533A4C828" modified="2013-07-24" version="1">MTSDKILGIDLGTTNSAFAVMEGGDPEIIVNSEGERTTPSVVAFSDDGEKLVGKPAKNQAVQNPERTIQSIKRHMGEEDYTVEVDGEEYTPEQISAMTLQKLKRDAEEYLGDEIEKAVITVPAYFSDSQRQATKDAGEIAGFEVERIINEPTAASMAYGVDEDSDQTVLVYDLGGGTFDVSILELGGGVYEVVATNGDNDLGGDDWDHAIIDWLTEEFENEHGIDLTEDRQALQRLKDAAEEAKIELSSRKETEINLPFITATDDGPIHLEKSITRAKFESLTSDLIERTVEPTEQALDDAGFDKGDVDEVLLVGGSTRMPQVQEKVEELVGQEPQKNVNPDEAVALGAALQGGVLGDEVDDIVLLDVTPLSLGVEVKGGLFERLIEKNTTIPTEESKIFTTAADNQTSVQIRVFQGEREIAEENELLGEFQLTGIPPAPAGTPQIEVTFAIDENGIVNVSAEDKGSGNTEEITIEGGTGLSDTEIDQMKQEAEAHAEEDQKRRERIEARNDAEASIQRAETLLEENEEDIDEGLHGDIEAAVEDLEAVVEDEDATVDEIREATEDLSDVLQEIGKQMYEGAAQAGGAGAAGAGPAGGPAGAGPAGGPAPGPEAGADEGEEYVDADVEDVTDESEDAGADDAEEVDPDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1A8</accession>
    <name>R4W1A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447260.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12115"/>
    <dbReference type="EnsemblBacteria" id="AGN02366">
        <property type="protein sequence ID" value="AGN02366"/>
        <property type="gene ID" value="L593_12115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180387"/>
    <dbReference type="KEGG" id="sali:L593_12115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2493"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_2"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="35444" checksum="777A53A6865F0E7C" modified="2013-07-24" version="1">MSGLRRFVLKRLLLTIPILWGVSVITFALVYLTPGDPVDLMTSLNPNISPAQEAALRERYGLNDPVYERYFDWMINALQGDFGRVYQTNRDVSDLVVERIPPTAALGLFGWAFGLIIAIPTGIYAAVKKDELADDVSRFVALFGISIPNFWLGLMLILIGALWLGWWPVLAPREPLYHPKMLWYLVLPGLTIGTASSAVLMRIMRSSMSEELNKEYVTAARAKGLPERTVILKHVLRNSLISVATVAAFLTANILAGSVVVEQVFNWPGLGRELVEAALDREVNLIMAITLFVGFVIIVMNLIADIVYAILDPRIRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W265</accession>
    <name>R4W265_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447625.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13960"/>
    <dbReference type="EnsemblBacteria" id="AGN02731">
        <property type="protein sequence ID" value="AGN02731"/>
        <property type="gene ID" value="L593_13960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180975"/>
    <dbReference type="KEGG" id="sali:L593_13960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2856"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15677" checksum="E708B21F2FCA6C69" modified="2013-07-24" version="1">MYDTIVVPTDGSEGPCRAVEQAYRLAAAFDATVHALYVVDETFPAHSHYDVVRENMEDTGESAVERIESNAPEGVTVEKVFLTGVPHEEIIAYAEDHDADLIAMGTNGRTGLSRFVAAGSTTERVVRASPVPVLTARRDDPTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W329</accession>
    <name>R4W329_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_01620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445171.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01620"/>
    <dbReference type="EnsemblBacteria" id="AGN00277">
        <property type="protein sequence ID" value="AGN00277"/>
        <property type="gene ID" value="L593_01620"/>
    </dbReference>
    <dbReference type="GeneID" id="16179879"/>
    <dbReference type="KEGG" id="sali:L593_01620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.329"/>
    <dbReference type="eggNOG" id="arCOG00167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_2"/>
    <dbReference type="OrthoDB" id="37194at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="81"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="33653" checksum="E0EDED2D8F84348E" modified="2013-07-24" version="1">MSTESDVPDLTRDDPLTDLTESGWAAFFVACAAVTLVTTLSIAAMLLYRSGQFFTEYSVSEFLTGTTFRAANEVFGIVPLVIATLSVTVVAGFIALPVGTLTAVYLSEYASTRSRAVLKPMLEILAGVPTIVYGIFALIYITPALQVVFPSLPTFNVLSASLMIGVMTIPMVSSISEDAMSAVPDDLRQAGYGLGATKFEVSTGIVVPASMSGIASSYILAVSRAIGETMILAVATGTLANMPEVREAAGVLPYIHPADVLMEPGMTITTAMIHSRGGELTGGSIAYDALFALGLTLFVVTLVLNVVSDVIAERYREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W349</accession>
    <name>R4W349_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpF</name>
        <name evidence="7" type="ORF">L593_01805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445206.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01805"/>
    <dbReference type="EnsemblBacteria" id="AGN00312">
        <property type="protein sequence ID" value="AGN00312"/>
        <property type="gene ID" value="L593_01805"/>
    </dbReference>
    <dbReference type="GeneID" id="16179953"/>
    <dbReference type="KEGG" id="sali:L593_01805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.366"/>
    <dbReference type="eggNOG" id="arCOG04102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_2_2_2"/>
    <dbReference type="OrthoDB" id="113093at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11290" checksum="B64DA88030FBA2EF" modified="2013-07-24" version="1">MSQEIAVIGSPEFTTGFRLAGIRRFANVPDDKKESDLDDAVEDTLADDGVGIVVMHQEDLEYLSRDVREAVETSVEPVVVTIGGDAGGGALRDQIKRAIGIDLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3A1</accession>
    <name>R4W3A1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">top6A</name>
        <name evidence="10" type="ORF">L593_02255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445296.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02255"/>
    <dbReference type="EnsemblBacteria" id="AGN00402">
        <property type="protein sequence ID" value="AGN00402"/>
        <property type="gene ID" value="L593_02255"/>
    </dbReference>
    <dbReference type="GeneID" id="16182707"/>
    <dbReference type="KEGG" id="sali:L593_02255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.457"/>
    <dbReference type="eggNOG" id="arCOG04143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="OrthoDB" id="22842at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="9">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="41954" checksum="4182432313A8BAAB" modified="2013-07-24" version="1">MTADTRLNEEEAREQLIDLAADIYDQMNAGEIPNMTIPTRTKSNIEYSEEEDVWVYGDRTSTRSANSVRGARKLLKAVYTVDFLADQLDQDRSSTLRELYYLSESWDNDEAQFNDQDESNQLVEDLEIVTEVTREDFHMRPEESGAKVMGPLHLREQTNRGDREIHCQLDVGQGGYQIPNNPDTIEFLDHDAEFVMCVETGGMRDRLVENGFDEEYNAIVVHLGGQPARATRRLTKRLHDELDLPVVVFTDGDPWSYRIYGSVAYGSIKSAHLSEYLATPEAEFIGIQPEDIVEYDLPTDPLSDSDVNALESELEDPRFQTDYWREQIELQLDIEKKSEQQALASHGLDFVTETYLPERLEEMGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3I8</accession>
    <name>R4W3I8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445451.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03030"/>
    <dbReference type="EnsemblBacteria" id="AGN00557">
        <property type="protein sequence ID" value="AGN00557"/>
        <property type="gene ID" value="L593_03030"/>
    </dbReference>
    <dbReference type="GeneID" id="16180490"/>
    <dbReference type="KEGG" id="sali:L593_03030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.614"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_1_2"/>
    <dbReference type="OrthoDB" id="124510at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8535" checksum="7B267A968A0A5EC1" modified="2013-07-24" version="1">MTDAIDVTETLDVKGASCPMPVVKTKSAIDDLAEGEVLEVLATDSGSMSDIDGWASGTDGVSLLDQIEDGDLYKHYVEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3N9</accession>
    <name>R4W3N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445541.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03480"/>
    <dbReference type="EnsemblBacteria" id="AGN00647">
        <property type="protein sequence ID" value="AGN00647"/>
        <property type="gene ID" value="L593_03480"/>
    </dbReference>
    <dbReference type="GeneID" id="16180737"/>
    <dbReference type="KEGG" id="sali:L593_03480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.706"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_2_0_2"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="463" mass="50355" checksum="2794506FD31CA558" modified="2013-07-24" version="1">MPDYDVVVAGAGTAGCYAAATAAQAGLDVAIVERKSEEEAGHIACGDALKGADAFPESIPKERIEPAFTNTGVDHGRFEIPSEDTVLEIPVPGELAVIDRWEYGRRIIDAADDAGVDIHYDTVVQTVLQEDDSGEPSPDGSGRVTGLKATRKGEPVEYDAGVVIDAAGALSLLQDETDFEDTTFDTNVTYSQFCSAYREIVHVEEPVEWEDALVFKPTERAAGYLWYFPRTETEINAGLGFQMTEEPMQLVDDLKRDLRERPEFEGAEVEDKLGAALPTRRPYDSAVAPGYMAVGDAAGHVNPTTGGGIAGAAYAGKYAAEAAMDALSNGGPTEDALWEYNERVMDHFGARYAALDVYNILSTAVDIDEMMGLLAAMPGEKIAESLYEGSTSLSWRLKARMAIDSFGYWRDIYGLYKTKSVADDLLAHYEQYPSSPAAFDDWQAERDEIMDRVYATTGADPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3X5</accession>
    <name>R4W3X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445676.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04155"/>
    <dbReference type="EnsemblBacteria" id="AGN00782">
        <property type="protein sequence ID" value="AGN00782"/>
        <property type="gene ID" value="L593_04155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180838"/>
    <dbReference type="KEGG" id="sali:L593_04155"/>
    <dbReference type="eggNOG" id="arCOG04706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051458_0_0_2"/>
    <dbReference type="OrthoDB" id="115796at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="35386" checksum="BF50288C81D78909" modified="2013-07-24" version="1">MARTALRSVSDAIEATRSFLLPFSVGRFAKLVLVALFLGTPGTPLPASPQFADPTYWRYSSPGDAANGDVDPGTIGGVAVASPDAWPAWLLAAVGIGLFLVVAYGFLGVVMRFVLVETLGSDEVRIRRDAGRHLRGSLGVLAVRIVLWSLVFPVVVLAALSTAGVGPLDLGGVGTLALAALATVALVLAWAIEVLTLQFVVPTMIAADRGVLAGWRRFWPTLRSQPVEYALYGVVRVALGVAVGIAAGIGVAVVLALAGVVLGTIGAIVVVAAGGFGSIGPGSLAVLGLLVAIFALVGIVASAAVAVPFQCYLWIYALFVLGDTDPGLDLVPDLREATRGQGAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W430</accession>
    <name>R4W430_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445771.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04640"/>
    <dbReference type="EnsemblBacteria" id="AGN00877">
        <property type="protein sequence ID" value="AGN00877"/>
        <property type="gene ID" value="L593_04640"/>
    </dbReference>
    <dbReference type="GeneID" id="16181088"/>
    <dbReference type="KEGG" id="sali:L593_04640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.948"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="37073" checksum="84A5327D78784268" modified="2013-07-24" version="1">MEYTTLGSTGMEVSKICLGCMSFGSQDEWMLDEDESREIIERALDLGITFFDTANVYSSGESEEILGDVLSEYDRDRLTIATKVRWPGAKEHRNAEGLSRKTIEQELDHSLDRLGMDTVDLYQIHRWDYETPIETTLRALDDAVRRGKVRHIGASSMYAHQFAEALHTSDREDLARFETMQNLYHLTYREEEREMLPLCDRENIGVMPWSPLGGGYLTRPHEEFDETTRGDHEKNNIGLPYHEGAGREINSRVQELAEEKGVTMAQLALAWHFHKEWVTAPILGTTSVEHLEQAVEAVEIDLSDSDLEYLEEPYEPVEIYGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W472</accession>
    <name>R4W472_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rpl44e</name>
        <name evidence="5" type="ORF">L593_05015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445846.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05015"/>
    <dbReference type="EnsemblBacteria" id="AGN00952">
        <property type="protein sequence ID" value="AGN00952"/>
        <property type="gene ID" value="L593_05015"/>
    </dbReference>
    <dbReference type="GeneID" id="16180405"/>
    <dbReference type="KEGG" id="sali:L593_05015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1022"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OrthoDB" id="106603at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10838" checksum="261228AE9259F14A" modified="2013-07-24" version="1">MEMPRRFNTYCPHCKAHHEHEVEKVRTGRTTGLKWMARRERAGRKGIGNRGRFSKVPGGDKPTKKTDLKYRCGDCGKAHLREGWRAGRLEFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4E0</accession>
    <name>R4W4E0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445966.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05615"/>
    <dbReference type="EnsemblBacteria" id="AGN01072">
        <property type="protein sequence ID" value="AGN01072"/>
        <property type="gene ID" value="L593_05615"/>
    </dbReference>
    <dbReference type="GeneID" id="16181444"/>
    <dbReference type="KEGG" id="sali:L593_05615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1148"/>
    <dbReference type="eggNOG" id="arCOG00578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085607_0_0_2"/>
    <dbReference type="OrthoDB" id="99528at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="22888" checksum="56F38C7A57C0F150" modified="2013-07-24" version="1">MSDADDSGFDKEAERERLREKYEREKEDRAAAEQMSDLLLKGATMTNAHCGECGSPIFRVDGQEFCPNCNVETEESAATHEPAADEAPADAAGTEDDATAEPSPDEQLADVISSGADAEPEPTGGTSIAERAAASVQSDDAGTASSQPSGESSGSDEPPAQPTDPAPQPAADASLADAQQSLLNAITHHARAATDADPRAAKDHLEAASEAAEALAEISPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4J4</accession>
    <name>R4W4J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-guanine transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446061.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06090"/>
    <dbReference type="EnsemblBacteria" id="AGN01167">
        <property type="protein sequence ID" value="AGN01167"/>
        <property type="gene ID" value="L593_06090"/>
    </dbReference>
    <dbReference type="GeneID" id="16181635"/>
    <dbReference type="KEGG" id="sali:L593_06090"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810411_0_0_2"/>
    <dbReference type="OrthoDB" id="40447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="104"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="416" mass="46951" checksum="F8F6251F4BCD103C" modified="2013-07-24" version="1">MASFEIVAEAGEARRGQLQINDRTLETPHLFPVINFYGGGNEGALFGGGVHRTVKEFLAHDNEVTGGKEYSDLFRGVMTSIASLTDYGIREKKLEWYLGNEIREWECFSDYDGMIFADSGGYKILEQGGGLEGEDFEKEIDQDKALDMQLDLGPDIVVNLDHPIHPDDEFEERLEKMEQTAANAARFAERREEVEGACYLTVHGYYDAMLERSFDLVEAELSEPIPEAFDGIALGSLVPRKDNVEVLVEAVSDCKHVMQQRGYDDLPLHVFGISGKAMPLLVAVGADSFDSASYLHQAINGKYSVSLFDYVPIDEADFDACDCRVCNDDFHRARMRNEMDDLYQKDILGSVAAHNLAIQQRELRQFRQLIAEGDQDQVAGYLEEAAKDQKGFRKFVYQLINERMNPYFEETDTTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4T5</accession>
    <name>R4W4T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06875"/>
    <dbReference type="EnsemblBacteria" id="AGN01322">
        <property type="protein sequence ID" value="AGN01322"/>
        <property type="gene ID" value="L593_06875"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06875"/>
    <dbReference type="eggNOG" id="arCOG04680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15917" checksum="BFF4C82CFC477C5A" modified="2013-07-24" version="1">MSRRRERPEGSSIAADRGQLSMPIVEAGIGVVLILSLAGLLALGTPAPQADDPQLEVYAEDVAVVLAEEPPRHGGTTRLDELTRSRDSFEREAPALERRVEALLPENLLYRIETPHGAVGFERPGGAVTGAATVTTQHGVVRVEVWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5H0</accession>
    <name>R4W5H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446601.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01707">
        <property type="protein sequence ID" value="AGN01707"/>
        <property type="gene ID" value="L593_08810"/>
    </dbReference>
    <dbReference type="GeneID" id="16182477"/>
    <dbReference type="KEGG" id="sali:L593_08810"/>
    <dbReference type="HOGENOM" id="CLU_2748364_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="8161" checksum="8DD521470E51765B" modified="2013-07-24" version="1">MADQQPRRSDRTVTEIDELRTVGFRLREIQRLLSMRVEQENRRLEAEGIDPVTEPGIGSEEARSGHERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5H3</accession>
    <name>R4W5H3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">L593_08835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08835"/>
    <dbReference type="EnsemblBacteria" id="AGN01712">
        <property type="protein sequence ID" value="AGN01712"/>
        <property type="gene ID" value="L593_08835"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1810"/>
    <dbReference type="eggNOG" id="arCOG01983">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="23505" checksum="EA64E533F9A1C23A" modified="2013-07-24" version="1">MAGSDATIADGHASIPRVKICGHTSSDDLAASVAAGADAVGVVADVDIETPREVTVRHAADLLAAVPPMATGVLVTMPATVGDAVELIGRTNPDAIQVHGTLEPDAVADLRQRVHVDVIAAIGADDESLAEYAAAADALLVDTPAEDGGGGTGETHDWDATRTATADLDVPVILAGGLDPANVADGIETVRPFGVDVASGVESSGGSKNHEAVREFVSTARAAPADGAVPAAEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5H9</accession>
    <name>R4W5H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08910"/>
    <dbReference type="EnsemblBacteria" id="AGN01727">
        <property type="protein sequence ID" value="AGN01727"/>
        <property type="gene ID" value="L593_08910"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08910"/>
    <dbReference type="eggNOG" id="arCOG08126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2893415_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6738" checksum="889D2610C7D7BCC5" modified="2013-07-24" version="1">MSIKDTVQSLLGGSNDLEDEVEAAPEESPSHVCQSCGEEYFSDPEMEIDTCRSCGGIKVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5I4</accession>
    <name>R4W5I4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446631.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08960"/>
    <dbReference type="EnsemblBacteria" id="AGN01737">
        <property type="protein sequence ID" value="AGN01737"/>
        <property type="gene ID" value="L593_08960"/>
    </dbReference>
    <dbReference type="GeneID" id="16182587"/>
    <dbReference type="KEGG" id="sali:L593_08960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1838"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_0_2"/>
    <dbReference type="OrthoDB" id="49614at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="42031" checksum="21BEC43C75247749" modified="2013-07-24" version="1">MVDAVLLQEAVQGATIIGAVLLILAVVTVASAIEIVNAYEKRALTVFGEYRKLLEPGINFVPPFVSKTYTFDMRTQTLDVPRQEAITRDNSPVTADAVVYIKVMNAKKAFLEVDDYKRAVSNLAQTTLRAVLGDMELDDTLNKRQEINAKIRRELDEPTDEWGIRVESVEVREVNPSKDVQQAMEEQTSAERRRRAMILEAQGERRSAIEKAEGDKQSNIIRAQGEKQSQILEAQGDAISTVLRARSAESMGERAVIEKGMETLESIGQGESTTFVLPQELSSLIGRYGKHLTGSDVKQDGEMLDSLEFDAETRELLGLDDIEKIISNIDEEADMQGAIEEIEEQAEAVKEGQTATDIKDPDEVVDETADDFEFEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S3</accession>
    <name>R4W5S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="632" mass="68900" checksum="2D42260EF996943C" modified="2013-07-24" version="1">MSDSDVAPVVYDLDPACSVEALQSGRPYLATVNGVVPYGVFVDLSESISGLVHESQLEDTYTVGDDVVVELDERKANGDLAFVPSDVEPVGAQLERVTPDYDLARTDQLETYLGTTIQVEAQIAQIRQTGGPTIFQLLDGHGIVPAAAFESAGVRAYPEVEIEDYVRVTGTVERHEDSLQVEIEDLTLLDGEAAVEVASTIDDAIEARAQPNDVEPLVEWDALEEMWPELERVATLLRTAILEGRPVSVRHHADGDGMCASIPLQRALERFVDDVSEDPEAAQHAIRRLPSKAPFYELEDATRDLTQALEDRARHGQRLPLLCMLDNGSTAEDVPSYETLKHYDVPIVVVDHHHPDPAAVADLVEEHVNPYLHGEDYAVTTGMLCVELARMVAPDSAEEPATDLRHVPAIAGLCDRSDADAMADYLDLAADAGYDEDDLRDVGEALDYAAHWLRYDDGRHLVDDVLNVGCDDPERHAELVDLLAERSREAIDDQLEATLPHVESEELDNGATLYRIDVENHAHRFTYPAPGKTTGAVHDHMISEHGEPAITIGYGPDFAVLRSDGVRLDIPEMVTELTEGIVGGGVSGGGHLVVGSIKYVKGRREEVLDSLVEKMAAAEIDEDLGTTTSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U7</accession>
    <name>R4W5U7_9EURY</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN00003">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04509">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="21404" checksum="CFCE861CDFE50EE2" modified="2013-07-24" version="1">MVDIRKLSFINEMAKVGTNGVADNMSTLTGEDAQMEVTTTNFVEIEDIKAQLDDGKRVGVRTRLMEPPHGHVLILFPESSAKKITALMLSDMVDDMSSVSGEMARSAVEELGNMMASGFIDGWADVLGTTIDVATPQLVYAPAGEIVERTAGLGGDDLALFFDSDLSVPSYEIKAEIYAFPDLEEFVEMVNNLETATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V7</accession>
    <name>R4W5V7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00018">
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        <property type="gene ID" value="L593_00315"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="entry name" value="DICT_dom"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterised_Vng0742h"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030471">
        <property type="entry name" value="STR_Vng0742h_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="28723" checksum="94FC8F01ED572BDA" modified="2013-07-24" version="1">MTLLSFVEELPDPDRSLAVLNRTEPEHVSELLEATFPEEDVPTIERVADDEDEDVVLLVEDGEVVARSPMGALGEQLLYVNSDIFRTGTRDLEDVVVPDVLLAMDEQPFHLRGYPESDREKLVLITISRLIERRAWEAGEGTLRASFQNLARIEDEKGTYEVYRSLVDTDVDVHLYGTADELPPEELRGIVHAGDTADFRRSWFVLFDPPSSGEDAIALVAYETEPRTWRGFWTYDPVRVQRIERYVEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W650</accession>
    <name>R4W650_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN00163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01050"/>
    <dbReference type="EnsemblBacteria" id="AGN00163">
        <property type="protein sequence ID" value="AGN00163"/>
        <property type="gene ID" value="L593_01050"/>
    </dbReference>
    <dbReference type="GeneID" id="16181458"/>
    <dbReference type="KEGG" id="sali:L593_01050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.215"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="26003" checksum="601ABFF4777C791B" modified="2013-07-24" version="1">MSDERHTASGSPDVEAVFWDIGGVILAADSVRTAHRAFVEELVTEYSTSHTAESALEVWRTTVGEYFRERDGTEFRPARKAYRLAIDEILDESVEDAEWRPSFRAVLEEHARPNPGAVEAIERLAAAPVHLGVISDVDEAEGRRLLETFGVLETFDSVTTSEAVGRTKPDPAMFETALETAGVEPSRAAMIGDRYDHDVAGSAEVGMTAVAYGADDGPAVDHRIEELRELPALLGFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W658</accession>
    <name>R4W658_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447021.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02127">
        <property type="protein sequence ID" value="AGN02127"/>
        <property type="gene ID" value="L593_10910"/>
    </dbReference>
    <dbReference type="GeneID" id="16182070"/>
    <dbReference type="KEGG" id="sali:L593_10910"/>
    <dbReference type="eggNOG" id="arCOG02281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109670_1_0_2"/>
    <dbReference type="OrthoDB" id="70649at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="233" mass="24783" checksum="54BFA6F4912FFEB3" modified="2013-07-24" version="1">MTATADSTSAEPLRARLRVEPHEAAGCAVLDAGDRGEDVVWTDCRSADDDGTCRAAVTVEVGDRRTREFVEGSVGEYCVCHAFREVECAADIERFCDGALVVSVTVPRRGALRDLVAALRDREASVHLEQVLPLAGEDGGRQLCLDAAAVTEKQREAIATAVDLGYYERPRSADLDAVAEALDVSRSAASQRLNAAETTLIHALVETTDIERVENDASAEAVTGAAAEEPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W663</accession>
    <name>R4W663_9EURY</name>
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        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpl10e</name>
        <name evidence="6" type="ORF">L593_10960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447031.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10960"/>
    <dbReference type="EnsemblBacteria" id="AGN02137">
        <property type="protein sequence ID" value="AGN02137"/>
        <property type="gene ID" value="L593_10960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180053"/>
    <dbReference type="KEGG" id="sali:L593_10960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2260"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OrthoDB" id="82104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="5">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="20113" checksum="5B4B8D49171B5C47" modified="2013-07-24" version="1">MVDKPASMYREISKPPYTRREYISGIPGSKIAQHQMGDSSRQPEDYPVQISLRVEEEVQLRHDAMEASRLSANRYLIEELGENTYRMVLRKFPHHVIRENKQATGAGADRVSDGMRQAFGKVVGTAARINANERLLTCYCEVEQAEAVKEAYRRAYNKISPPCRIDVERGEELLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E0</accession>
    <name>R4W6E0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447141.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11520"/>
    <dbReference type="EnsemblBacteria" id="AGN02247">
        <property type="protein sequence ID" value="AGN02247"/>
        <property type="gene ID" value="L593_11520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180824"/>
    <dbReference type="KEGG" id="sali:L593_11520"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="28503" checksum="51BFF5E06E526143" modified="2013-07-24" version="1">MTEEARAWWEATADDFQRELDLPVELNWMGLGTHVPRTGEHGPADLDLLPDVDGAEVVELGCGGGQCTVALAKRGADGTGIDVSPSELEHARELATEHDVAESIEFVEGDVRDLSMLEHDSFDVACDAWVFQWVDDLRACFEEARRVLRPDGRFVFSMPHPTYDLVDPETHEVVESYFGEPRQVEDVEGMETPMVTYRHRISDVFADLRAANFAVEQLREPGTDAPEAYEDGPWGEFTADLMAKLPTTLIVDARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6M3</accession>
    <name>R4W6M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein, NifU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445367.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02610"/>
    <dbReference type="EnsemblBacteria" id="AGN00473">
        <property type="protein sequence ID" value="AGN00473"/>
        <property type="gene ID" value="L593_02610"/>
    </dbReference>
    <dbReference type="GeneID" id="16180279"/>
    <dbReference type="KEGG" id="sali:L593_02610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.529"/>
    <dbReference type="eggNOG" id="arCOG02077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_2"/>
    <dbReference type="OrthoDB" id="89731at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="15162" checksum="E157B9A76EE4C516" modified="2013-07-24" version="1">MGMGSDMYRQQILDHYKNPRNYGEIEEPTYSHVGENPMCGDEITVDVLLEDDTIEQIAFRGDGCAISQASASMLSERLTGASVEELVEMDRDDVIDMLGVDISPMRVKCAVLAEKVAQDGYEIYEGEKDVDRTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6M7</accession>
    <name>R4W6M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445372.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02635"/>
    <dbReference type="EnsemblBacteria" id="AGN00478">
        <property type="protein sequence ID" value="AGN00478"/>
        <property type="gene ID" value="L593_02635"/>
    </dbReference>
    <dbReference type="GeneID" id="16180341"/>
    <dbReference type="KEGG" id="sali:L593_02635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.534"/>
    <dbReference type="eggNOG" id="arCOG02200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1297469_0_0_2"/>
    <dbReference type="OrthoDB" id="67226at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="21680" checksum="254EA5F53898B3C1" modified="2013-07-24" version="1">MNATQVTVRDVAEVGPDTIAMTLATPDGFDADPGEFVLVRATVDGEELARHYTLSSPTVDDTFEITVGIDPDGDLTPWLAEREPGDTLSVEGPFGTVTYEGDGDVVVLAGGPGVGPAVGIGERARSADHDAAIVYLDGTPAHETRLSTLSNAGASVTVANDEDSFTAAVADVADVGQVYVFGFKEFCELSLDALEAAGVDPDDALVESFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6R5</accession>
    <name>R4W6R5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing] subunit A</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaAA</name>
        <name evidence="5" type="ORF">L593_02910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445427.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02910"/>
    <dbReference type="EnsemblBacteria" id="AGN00533">
        <property type="protein sequence ID" value="AGN00533"/>
        <property type="gene ID" value="L593_02910"/>
    </dbReference>
    <dbReference type="GeneID" id="16180288"/>
    <dbReference type="KEGG" id="sali:L593_02910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.589"/>
    <dbReference type="eggNOG" id="arCOG00087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_4_2"/>
    <dbReference type="OrthoDB" id="79931at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01510">
        <property type="entry name" value="GMP_synthase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023686">
        <property type="entry name" value="GMP_synthase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19821" checksum="8070F24F8BEC990D" modified="2013-07-24" version="1">MTRIDVVDNHGQFTHLEQRALRDLGIDCEIIDNDTPPEEIEADGLVLSGGPDMDDRGRCGDYLDLDIPVLGICLGMQAMALELGGEVGGGDYGGYADVTVELLDEDDPLTGSLYPETRVWASHADEVTELPEGFTLTGRSDVCDVESMSDADRDLYGVQWHPEVAHTAEGEEVFENFVALCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W1</accession>
    <name>R4W6W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-NAD/AcoX kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445497.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03260"/>
    <dbReference type="EnsemblBacteria" id="AGN00603">
        <property type="protein sequence ID" value="AGN00603"/>
        <property type="gene ID" value="L593_03260"/>
    </dbReference>
    <dbReference type="GeneID" id="16180477"/>
    <dbReference type="KEGG" id="sali:L593_03260"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_2_0_2"/>
    <dbReference type="OrthoDB" id="100944at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="25974" checksum="19ED98006247CF25" modified="2013-07-24" version="1">MNEAVSVIGVPTTEAAARQDLVDAVEAAGAEARVGALGDFLAASSDPESSGVDAVVAVGGDGVRAAATRRPSVPILPVDADPGLRSVPADEADRAIEAVVAGEATTEAAPLLEVAVDDAIHTTAYRDVTLITAEPAKISEFEIARAGGGHLDTVRADGVVVATPVGSHGYAAAGEGPLLEPGTGLAVVPVAPFRTDRNRWVVPVERVTVRVQRDEAAVTVEADGEVLTTVGRGATLSLRPAATMGVLVTEQSVRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W5</accession>
    <name>R4W6W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Menaquinol--cytochrome-c reductase (Cytochrome bc complex) cytochrome b/c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_03285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445502.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03285"/>
    <dbReference type="EnsemblBacteria" id="AGN00608">
        <property type="protein sequence ID" value="AGN00608"/>
        <property type="gene ID" value="L593_03285"/>
    </dbReference>
    <dbReference type="GeneID" id="16180486"/>
    <dbReference type="KEGG" id="sali:L593_03285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.665"/>
    <dbReference type="eggNOG" id="arCOG04594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088834_0_0_2"/>
    <dbReference type="OrthoDB" id="63441at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="12">
        <location>
            <begin position="60"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="29123" checksum="945901258927BD0B" modified="2013-07-24" version="1">MSETPDSDEVRTDGGAITPSDDSPSFRERKERTDGLSRLTYEYFERSRREDEVLRDDSDYVERDVLGFPAWPHEMIRNLSITSFFVGVILFVAALMPPPLEAPANPTSTPAVILPDWYLYWSFGILKTQALNLELAILGGQTLATDRTFAVLLHGPIILMLFLVPFLNKGSARRPVEEPFWAAVGVFGVVLSFTLSLLAIKNLMATRVPLLTSHMQLWLSFALPIVTGTITYAVLKSMQEGYMYDLNRRYYRLRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X8</accession>
    <name>R4W6X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445522.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03385"/>
    <dbReference type="EnsemblBacteria" id="AGN00628">
        <property type="protein sequence ID" value="AGN00628"/>
        <property type="gene ID" value="L593_03385"/>
    </dbReference>
    <dbReference type="GeneID" id="62368346"/>
    <dbReference type="KEGG" id="sali:L593_03385"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010184_0_0_2"/>
    <dbReference type="OrthoDB" id="67263at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="4">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13122" checksum="A4FEB49276F4FB82" modified="2013-07-24" version="1">MGRQRTRRGRSLLDGGSSVDDAGSRTSEGVWDADAATASEATEPEETTPVSTEPETTAAVDLDKLTDRQREVLGTAYEMGYYQYPRGANASEVAEALDICPSTLAEHLAAAQTKVLDDLLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W730</accession>
    <name>R4W730_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KEOPS complex Pcc1-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13640"/>
    <dbReference type="EnsemblBacteria" id="AGN02667">
        <property type="protein sequence ID" value="AGN02667"/>
        <property type="gene ID" value="L593_13640"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13640"/>
    <dbReference type="eggNOG" id="arCOG01354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032957_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="121" mass="12656" checksum="FC3635E74B85E660" modified="2013-07-24" version="1">MMTGDDQTETTDATEAVIGTRRATITSEVDSPATVAAAIAPDDTEEIDTRVEDGLVVSTIERETTGGLEATIDDYVVALDVATTTAGHATVDEAGIEAAIEESQTDSTAEQLDERHDTDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E1</accession>
    <name>R4W7E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447751.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02857">
        <property type="protein sequence ID" value="AGN02857"/>
        <property type="gene ID" value="L593_14605"/>
    </dbReference>
    <dbReference type="GeneID" id="16180111"/>
    <dbReference type="KEGG" id="sali:L593_14605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2982"/>
    <dbReference type="eggNOG" id="arCOG06216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159080_0_0_2"/>
    <dbReference type="OrthoDB" id="93794at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043828">
        <property type="entry name" value="DUF5805"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19121">
        <property type="entry name" value="DUF5805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="134" mass="14968" checksum="F17C0B9A7D4E6CC0" modified="2013-07-24" version="1">MTEQDPERTSVRTYVPAYQKEEWATRANELEMSLSEFVRTMVQAGKRGFEGGQPAAESRDREKGGSGDATPGGQDLETTVLDALENGPLEFDELVDVVAEDFRRDVDEALGRLEEEDRVEHDRLDGGYRVTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I1</accession>
    <name>R4W7I1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroneopterin aldolase</fullName>
            <shortName evidence="1">DHNA</shortName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptD</name>
        <name evidence="4" type="ORF">L593_05145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal dihydroneopterin aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05145"/>
    <dbReference type="EnsemblBacteria" id="AGN00978">
        <property type="protein sequence ID" value="AGN00978"/>
        <property type="gene ID" value="L593_05145"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1050"/>
    <dbReference type="eggNOG" id="arCOG04705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149105_1_0_2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.20">
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    </dbReference>
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        <property type="entry name" value="DHNA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHN_aldolase_MptD"/>
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        <property type="entry name" value="MptD_sf"/>
    </dbReference>
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        <property type="entry name" value="MtpD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04038">
        <property type="entry name" value="DHNA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF143560"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHNA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DHNA" evidence="3">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16184" checksum="96DB1C1CA1B30CCC" modified="2013-07-24" version="1">MTEPTDAERAAFEAGIKFGALYHQFAGTPVSPESAESLATAMAESIENQPFCENVEVQPLEERIERAVAGLNPLDETADPASSDAGSESPDAGPLDAEEPAGDATDEADYTELTGTLFDAIVEVERADTKVRAEMATEGDYPLMSLVDVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7N0</accession>
    <name>R4W7N0_9EURY</name>
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            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
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    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ORF">L593_05570</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN01063.1"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1138"/>
    <dbReference type="eggNOG" id="arCOG04473">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_3_2_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="10144" checksum="620D4F28AC8A5BCF" modified="2013-07-24" version="1">MSASDFEERVVTVPLRDAAAAPSHQRSDKAMKLIRGHLAKHFSVEEDAVRLDPSINEAVWNAGNASPPRKLRVRAARFQEEGEGVVEAEHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S8</accession>
    <name>R4W7S8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Putative phosphoribosyltransferase</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_00370</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00370"/>
    <dbReference type="EnsemblBacteria" id="AGN00029">
        <property type="protein sequence ID" value="AGN00029"/>
        <property type="gene ID" value="L593_00370"/>
    </dbReference>
    <dbReference type="GeneID" id="16182416"/>
    <dbReference type="KEGG" id="sali:L593_00370"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.74"/>
    <dbReference type="eggNOG" id="arCOG00041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_2"/>
    <dbReference type="OrthoDB" id="115683at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="23106" checksum="220C1BD76C2E11A0" modified="2013-07-24" version="1">MFDRGQKSRFTDRTEAGKRLAAEISDRGVDADLVLAIPRGGLPVGREVADAIDRPLDVIVASKVGAPWNPELAIGAVGSDGSAWFDEAVIERHGIDQEYVQRKRESVAEAAAEKEARYRGEEASTSLDGSTVLLVDDGAATGSTTIAAIRLARARDAERIVLALPVAPPDTLDTLRREADEVICLLEPTGFGAVGQFYEDFGQVSDEEAIELLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X4</accession>
    <name>R4W7X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase MaoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445038.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00945"/>
    <dbReference type="EnsemblBacteria" id="AGN00144">
        <property type="protein sequence ID" value="AGN00144"/>
        <property type="gene ID" value="L593_00945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180171"/>
    <dbReference type="KEGG" id="sali:L593_00945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.194"/>
    <dbReference type="eggNOG" id="arCOG00778">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_3_0_2"/>
    <dbReference type="OrthoDB" id="88190at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22552" checksum="BFB9BA2B8D9164B6" modified="2013-07-24" version="1">MSDTRGVNGFTAVADAWMDLTSTVVRNTAAANRAAFSAFVTEDESNGDGFPEETVPSVAGEEPDWTFERSVDRREDIGVGDTVTFSKRLTDEDVHAFGRASGDTNRLHLDDDFAQRTRFGGRIVHGTLASGLISAALARLPGLTIYLSQDLKFSAPVGIGDRVSANVEVVEDLGENQYRLTTEIHDEDEDTTIIDGEAVVLIDDLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z0</accession>
    <name>R4W7Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06930"/>
    <dbReference type="EnsemblBacteria" id="AGN01333">
        <property type="protein sequence ID" value="AGN01333"/>
        <property type="gene ID" value="L593_06930"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06930"/>
    <dbReference type="eggNOG" id="arCOG08162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210060_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6562" checksum="E76540D07607B042" modified="2013-07-24" version="1">MLEHLASECSAPDCERTLSEDRRMLTMQTPDGVRRAYECECGAVTVTVLSDETIREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W801</accession>
    <name>R4W801_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446267.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01373">
        <property type="protein sequence ID" value="AGN01373"/>
        <property type="gene ID" value="L593_07130"/>
    </dbReference>
    <dbReference type="GeneID" id="16182014"/>
    <dbReference type="KEGG" id="sali:L593_07130"/>
    <dbReference type="eggNOG" id="arCOG15060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629884_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="8857" checksum="78C502832D9CFB45" modified="2013-07-24" version="1">MTACPADAIERTYHRYLAGDWDSLQRWAWVYVHVGMVLATALVGYTVARGRLRLTALLLPLPAFFLARRYTYARPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W842</accession>
    <name>R4W842_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445188.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01705"/>
    <dbReference type="EnsemblBacteria" id="AGN00294">
        <property type="protein sequence ID" value="AGN00294"/>
        <property type="gene ID" value="L593_01705"/>
    </dbReference>
    <dbReference type="GeneID" id="16179973"/>
    <dbReference type="KEGG" id="sali:L593_01705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.346"/>
    <dbReference type="eggNOG" id="arCOG04425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042917_0_0_2"/>
    <dbReference type="OrthoDB" id="38320at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="39999" checksum="D09ABE37D99A62E0" modified="2013-07-24" version="1">MTAFTSVEATTLLSGTSEWMGTEEAAALAHHPLESIETEFPHYVGSVDAPDDEVQPKADHPVFYGCFDWHSAVHSHWALVRQLRLFEDHPERERIVASIDDRLTPAAIEAEVGYFEEHPTFEKPYGWAWLLQLAAELSLWDDDLADGWQSTLASLEEQIRALVESEFLTQDEPFRVGTHQNTAFALGLVLDYARTVADESLASAVEDATRGFYLDDRSYPVEYEPLGWDFLSPALAEADLLRRVLAPDEFAAWVDDFFPDLTIEPYDSILDPIEVDPDPDDGLALHFVGLNVSKAWALAGLASTLEAHPYSGLFDRSAQRHAEAGLEVAFTDDYAGAHWLSSFVLYLLTRDEGGIAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A9</accession>
    <name>R4W8A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445378.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02665"/>
    <dbReference type="EnsemblBacteria" id="AGN00484">
        <property type="protein sequence ID" value="AGN00484"/>
        <property type="gene ID" value="L593_02665"/>
    </dbReference>
    <dbReference type="GeneID" id="16180296"/>
    <dbReference type="KEGG" id="sali:L593_02665"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_2_2"/>
    <dbReference type="OrthoDB" id="88014at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="26220" checksum="87373268CD94D5B8" modified="2013-07-24" version="1">MPLDVDAICFDLDDTLCVYERTVEDLLALSFERAAVEPFFDGPTYRTYFDRFLEDFDDADALRTHCFEAIAADQGRDPALGREVAREYAAARDQSNVQPRSGVPEVVRRLGERYPIALVTNGDASMQGAKLEGVGLSDAFDVTVFAGEDAAPKPSAEPFEHALVELGVRADRTVHVGNSLESDVAGATAAGLQSVWTPAEHDLPADVQAAERLDPDHPEIEPRPDVVLSGVDALADELGIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H6</accession>
    <name>R4W8H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445548.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03515"/>
    <dbReference type="EnsemblBacteria" id="AGN00654">
        <property type="protein sequence ID" value="AGN00654"/>
        <property type="gene ID" value="L593_03515"/>
    </dbReference>
    <dbReference type="GeneID" id="16180578"/>
    <dbReference type="KEGG" id="sali:L593_03515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.713"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269976_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="22103" checksum="5ED665F6DE53C4F7" modified="2013-07-24" version="1">MSGSDAAREFDKSHRIRTSVGRRQLLAAVSGLAGLAGCSALSDDDGSDGGSDDGHGPVVADAGEEAETQTVDTVAVGETRGRVASGGASIGRVQMAVQLAQGSEQVDLSAMTIQYVAHDASVTLAHQSTSTDGEPAFGTRAVSAEDEHDAVLESASDEYEIVVPLGDAAGEYPALRRLEPGTAAQLTLAPDTDAQRVVRVEVPSSLGDVEAGETVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I9</accession>
    <name>R4W8I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase RecJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445573.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03640"/>
    <dbReference type="EnsemblBacteria" id="AGN00679">
        <property type="protein sequence ID" value="AGN00679"/>
        <property type="gene ID" value="L593_03640"/>
    </dbReference>
    <dbReference type="GeneID" id="16180641"/>
    <dbReference type="KEGG" id="sali:L593_03640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.739"/>
    <dbReference type="eggNOG" id="arCOG00427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042622_0_0_2"/>
    <dbReference type="OrthoDB" id="45290at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="396"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="500" mass="51816" checksum="2982342C3C5BFB58" modified="2013-07-24" version="1">MTGPIPALTDRANRAAERLAAADHVLLASHADADGLASAAVGAAALERAGIPHDVQFADQLDEATIQRLASGREDVVFLTDFGSGQLDDVYAHLDPEATIVADHHQPLSPDAVPAGAPATAEYADAPYHVNPLLVGLDGARECSGAGATYAVARAIAERDPPAALGPEHAIQPGSDPDPRNRDLAALAIVGAVGDRQREDGELVGANVAIAAEGEAAGVLTTETDLGAYGTQTKPLPELLAHADEIRVPGVATDRNAAARFLDGLDLKLRTDGEWRRWAELTGEERQTVASGLCQRAIQRGVPAERIDEMVGTAYTLSGEEPATQLRDASEFATLLNATARYERSAVGLAVLLGDRDGALEEATDLLAEHRRNLSRGVRWVEDHGVTIESHCQWFDAGSEIPATIVGIVAGMAVGADGVDPSIPIVAFAEDGDEVKVSARATGGLVRRGVDLSEAMATAASAVDGSGGGHTVAAGATIPPDSTDEFVSVVDDVLATQLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L4</accession>
    <name>R4W8L4_9EURY</name>
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        <submittedName>
            <fullName evidence="8">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">L593_03815</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="AGN00714.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_03815"/>
    <dbReference type="EnsemblBacteria" id="AGN00714">
        <property type="protein sequence ID" value="AGN00714"/>
        <property type="gene ID" value="L593_03815"/>
    </dbReference>
    <dbReference type="GeneID" id="16180615"/>
    <dbReference type="KEGG" id="sali:L593_03815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.774"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OrthoDB" id="28394at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="141"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="685" mass="73668" checksum="338CBAF796662FC7" modified="2013-07-24" version="1">MVNAFDLVPLIAALPFLSFVIAVTVGRWLPKEGALPGVAATAASLALSIWAFLTVRADGAHYDNELYTWIDAGAFELSFGVLVDPLSSMMLVIVSLVAFLVHVFSMGYMNDDELHREKGGFPRYYAGLGLFSASMLAFVFASNLLMAFMFFELVGLCSWILIGFWFREEAPPSAAKKAFLVTRFGDYFFLVGVVGVLATFGTAGFAQEGFPQIAAHFLETGEGADHIWVPGDLGTQQWFSILGLLVLGGVIGKSAQFPLHTWLPDAMEGPTPVSALIHAATMVAAGVYLVARMFGFYAGLPTVLAIIAFIGGFTALFAASMGVVKDDIKQVLAYSTISQYGYMMLALGVGGYVAASFHLLNHAFFKALLFLGAGAVIVATHHHQDMWKLGGLKRSMPVTYYTFLAGSLALAGIVPFSGFWSKDEVLYDALLVGLEEPLFMAAYAMGLAAVFLTGFYTFRMVFLTFHGEPRSEHARNPEPLRWNTKGPLAVLGVLAAVTGLINMKPIAEVLGSDDILYLEHWLDDGAAADGGAWMGDLTYHHYGDLVHEVAGLHEASLAPYAPAAVSLALAIGGALLAKRLYDVPDPEPATERLGSAGTLLQRNYYLDEFQVWLATGVTEPVARACNTFDQGIIDGTVNATSSVSLFSGQRVRRVQSGLVTNYVAVIVMSLIVFVLAVGIVGGWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L6</accession>
    <name>R4W8L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)H-quinone oxidoreductase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03840"/>
    <dbReference type="EnsemblBacteria" id="AGN00719">
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        <property type="gene ID" value="L593_03840"/>
    </dbReference>
    <dbReference type="GeneID" id="16180637"/>
    <dbReference type="KEGG" id="sali:L593_03840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.779"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_2"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40302" checksum="28FBA11AE242D0DE" modified="2013-07-24" version="1">MSGALATLAAAPTLLQSGDGTGDSAVLLPEWLADALGLDGLGGVGTAIAALIAAFAIANVMLIQAALAGPWLKRKIAAAFWGKLGPNRMGPGGSLIIVADAVRMLSKELIVPDGADRPAWDLAPIVVAGSAMVGFAVIPFGEIGGVQIQLADPEIGLVLVFAIASVTSVGLVMGGYASSNKYSMLGSLRAVAQNIAYEIPLILAAGSVVIFAGSLQLSEIVAAQQETLVGPIPAWYILVNPFAFVLFLTANLAEVGRNPFDIPEAPTEIVAGYQTEYSSVYFVLIYLGEFLHIFLGGAIAAVVFLGGGAGPVLPGPIWFVAKMWAFFLFTQWARQTFPRVRIDQLIEIGWKGLLVLTFANLILTAVLVGVLEGDLELSMAALQVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q6</accession>
    <name>R4W8Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04415</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00834.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_020445728.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04415"/>
    <dbReference type="EnsemblBacteria" id="AGN00834">
        <property type="protein sequence ID" value="AGN00834"/>
        <property type="gene ID" value="L593_04415"/>
    </dbReference>
    <dbReference type="GeneID" id="16180929"/>
    <dbReference type="KEGG" id="sali:L593_04415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.900"/>
    <dbReference type="eggNOG" id="arCOG01908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057502_0_0_2"/>
    <dbReference type="OrthoDB" id="69256at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="23124" checksum="39F376A4E7C8141B" modified="2013-07-24" version="1">MDIEQFTTAHEPTDSDAPFQRENSYTLDVAVDGTMMAKAGSMVAYTGEFTFHGKASVEGGISGYLKDKVTGEGTPIMEIEGQGHAYLADTGKKVQVLDLDADDTITVNGEDILAFEPDLGYEITTIDSLSGAFAGGLTNIELSGPGLVALTTYGDPLVVEPPVTTDPAATVAWSTANSPSFETNKVVEIGQTSGENVQMRFEGQDGFVVVQPYEEHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R6</accession>
    <name>R4W8R6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446922.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10415"/>
    <dbReference type="EnsemblBacteria" id="AGN02028">
        <property type="protein sequence ID" value="AGN02028"/>
        <property type="gene ID" value="L593_10415"/>
    </dbReference>
    <dbReference type="GeneID" id="16179846"/>
    <dbReference type="KEGG" id="sali:L593_10415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2147"/>
    <dbReference type="eggNOG" id="arCOG01757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_2"/>
    <dbReference type="OrthoDB" id="40164at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="33"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="112"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="34472" checksum="DE97771C3182712D" modified="2013-07-24" version="1">MSPPADVLVLSKGTHGEPVEAYGAKLRERLPDHDVAVATTPSEERELIEGVPYVTGRAIDEELLELADAMELFACGYAGTDHLPMDALRAAGVTVTNASGVHGPNMAEQVIGAILAAVRRFEAGQRRQSRNEWRHYQTHELMGDTVTIVGLGAIGTAIADRLDGFGVDTIGIRYSPEKGGPTDEVLGFDDEAAFEEALARTDQLVLACPLTETTEGLIGRDELGTLPPSAYVVNVARGPVLDTDALLWALRSNRLRGAHLDVTDPEPLPNDHPLWDLETVRITPHNAGYTPKYYDRLADILAGNVRRSEAGEELENVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W920</accession>
    <name>R4W920_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
            <shortName evidence="6">GDH</shortName>
            <shortName evidence="6">GlcDH</shortName>
            <ecNumber evidence="6">1.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gdh</name>
        <name evidence="10" type="ORF">L593_11675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447172.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11675"/>
    <dbReference type="EnsemblBacteria" id="AGN02278">
        <property type="protein sequence ID" value="AGN02278"/>
        <property type="gene ID" value="L593_11675"/>
    </dbReference>
    <dbReference type="GeneID" id="16180496"/>
    <dbReference type="KEGG" id="sali:L593_11675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2406"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_1_0_2"/>
    <dbReference type="OrthoDB" id="43162at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047934">
        <property type="term" value="F:glucose 1-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047935">
        <property type="term" value="F:glucose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019595">
        <property type="term" value="P:non-phosphorylated glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02127">
        <property type="entry name" value="Glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026583">
        <property type="entry name" value="Glc_1-DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="9">
        <location>
            <begin position="158"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="371" mass="40028" checksum="99A5767D80423572" modified="2013-07-24" version="1">MKVVAVREGEQTPTVMEKPCPEPSEGEALVRTLRVGVDGTDHEVLSGGHGGFPEGEDHLVLGHEAVGVVEDPNGTDFEAGDVVVPTIRRAPERVRSDGGASAESVAANEPNEYFARGEPDMAPDGMYHERGIVGAHGFMAEYFTSPAEYLVSLPPELADVGFLVEPLSITEKALELSYASRSTFEWDPESAIVLGNGCLGLLTLGMFEHTEGIERSYCLGRRDRPDPTIDIIEELGAEYVDSRETPVDELPEAVEPMDLVYEATGYAPHAFQTIDALAPNGVGALLGIPGSWEFEIDGGALHEEFVLHNKALIGSVNSHVRHFETAIEDLQALPDWLIDAVVTGVYGTDDLEQAFDDSNTTIKTAVELSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W941</accession>
    <name>R4W941_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447237.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12000"/>
    <dbReference type="EnsemblBacteria" id="AGN02343">
        <property type="protein sequence ID" value="AGN02343"/>
        <property type="gene ID" value="L593_12000"/>
    </dbReference>
    <dbReference type="GeneID" id="16180005"/>
    <dbReference type="KEGG" id="sali:L593_12000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2469"/>
    <dbReference type="eggNOG" id="arCOG04683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269885_0_0_2"/>
    <dbReference type="OrthoDB" id="76804at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="24268" checksum="20FCE04AE6167EC2" modified="2013-07-24" version="1">MDRDAAVDRVERLVDAVATERMPVPVREVWVYGDLALGVDPVDRLDVYLTKDVLLEDDSDLDEDGAPNPEAIEAEHGVEGIGSTVRTDWAAEHPEHLRANPNGYAAPERCLAAHLLGDDEPIHLEVCNTGFEDNVTQRLRGAVARDAYEQLLDPRGVCLWVDGVRSDTAFEKLRESALPFPPLSEALGQLGLEDDEAERAAKAVHSWREAQDGVTVRGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W965</accession>
    <name>R4W965_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02428">
        <property type="protein sequence ID" value="AGN02428"/>
        <property type="gene ID" value="L593_12445"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2559"/>
    <dbReference type="eggNOG" id="arCOG13341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099837_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="22534" checksum="3CA3295C13CF58E8" modified="2013-07-24" version="1">MAIVVLGAIYWFGIRPWMMNWGSDAAERARPLPGDDVLPDPDGESTMAIGIDAPPEDVWPWLVQIGQERGGFYSYTWAENALGFGIQNADEIVPEYQDIAVGDTVRLAREDRYPETKLEVASIDPNRSLVLRSPDQPPWWVWAFVLESVEDRTRLLVRARISLPENRLIRLLSQVVLDPVTFVMTRGMLRGVKSRVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B8</accession>
    <name>R4W9B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446253.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07060"/>
    <dbReference type="EnsemblBacteria" id="AGN01359">
        <property type="protein sequence ID" value="AGN01359"/>
        <property type="gene ID" value="L593_07060"/>
    </dbReference>
    <dbReference type="GeneID" id="16182003"/>
    <dbReference type="KEGG" id="sali:L593_07060"/>
    <dbReference type="eggNOG" id="arCOG02756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130787_2_0_2"/>
    <dbReference type="OrthoDB" id="104219at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="14470" checksum="3267AEC65BB68DAD" modified="2013-07-24" version="1">MTRTLHVTIQPVSDRDDLEADLAALDAGEDIDSQDPTLAIEDLETFGRIFRGTNLELLEAIVQTEPASIRELADAVDRHPPDVLANVRELEDYGLLELEQDGRAKRPVVWYDEIDVDIPLGDRSVDPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C3</accession>
    <name>R4W9C3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="6">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_07135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446268.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07135"/>
    <dbReference type="EnsemblBacteria" id="AGN01374">
        <property type="protein sequence ID" value="AGN01374"/>
        <property type="gene ID" value="L593_07135"/>
    </dbReference>
    <dbReference type="GeneID" id="16182015"/>
    <dbReference type="KEGG" id="sali:L593_07135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1458"/>
    <dbReference type="eggNOG" id="arCOG01484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_2"/>
    <dbReference type="OrthoDB" id="72994at2157"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="10">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="24946" checksum="3E6AF0EDF136C147" modified="2013-07-24" version="1">MHVRVNAAVSADGKLSNRHREQVPISGPADFERVDRIRAEFDAVLVGVGTVLADDPSLTVDDPDLRAEREGHGEPVNPARVVADSRARTPTDARILDDEATTYVLVSEAAPADRRRGLEAAGAELVVADASGAGDDADAGDQRVDLPAAFEQLESVHGVDSLMIEGGGELLYSCFEAGLVDELTLYVGSTIIGGRDAPTLVDGEGFVAEFVDLELRDVERVDDGVLVTWAVSSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D0</accession>
    <name>R4W9D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446288.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07235"/>
    <dbReference type="EnsemblBacteria" id="AGN01394">
        <property type="protein sequence ID" value="AGN01394"/>
        <property type="gene ID" value="L593_07235"/>
    </dbReference>
    <dbReference type="GeneID" id="16182596"/>
    <dbReference type="KEGG" id="sali:L593_07235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1477"/>
    <dbReference type="eggNOG" id="arCOG06227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764235_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4397" evidence="2">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="2">
        <location>
            <begin position="187"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="37385" checksum="898A031F9880A4DF" modified="2013-07-24" version="1">MASTIPYTRLIVVLLSVALVGSVVALGGVAAVDQHTDDNGTDGDMADGEADENATDGDMADDEADENATDDEAAAAADPQQTTYLRVVHASPDAPAVDVLIENDTVLSNVSFGDVSDYLPGPAGTYNVTIAAAEDPDTVVFDDEVTLEARTVTTIAASGEISENGTAPFAPVAFNDNAWTPEDDMSALRVVHLSPDAPAVDITAGNGSVVIADDVEFGNASDYVTVPAGDYTAEIRPATEGNNGTVVTTVDVSLEGETAYSAWALGYLNPDEAPADTPFQVVATEDATMSVELPGDGEMDEDDEMEDENETDADADDEMEDDESDAADDADADDDGENETATDDGAGAADDAANDDECEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I7</accession>
    <name>R4W9I7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446448.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08045"/>
    <dbReference type="EnsemblBacteria" id="AGN01554">
        <property type="protein sequence ID" value="AGN01554"/>
        <property type="gene ID" value="L593_08045"/>
    </dbReference>
    <dbReference type="GeneID" id="16182293"/>
    <dbReference type="KEGG" id="sali:L593_08045"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="35542" checksum="B5C352F6BD2BACCB" modified="2013-07-24" version="1">MRAATLTDVGDIAVEERDRPVPGPEEVLVEVGACGVCMTDFHMYHGTFAADLPVVPGHEAAGEVVAVGDDVRATAVGERVAVNPTVACNACSACKRGDTHLCANNTSIGGAADRVIDGAFAEFVRVPASNVEPIGDLPAAAAALAEPLACCVHGADRTGLQQGDSAALIGAGPIGLLLVQTLRNRGVSPIAVSEPDDERRALAAEFGADLVVDPTETDPVETIATEVGRVDAAIEAVGRVATLEQAHDLTGPGGATLVFGVPPEDAKLEVRPFEVFFEEVDLRGSYSLTQASFERAVELIRRARIDTASLVTDEIGLGELPAAFERMERGEGLRHVVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M4</accession>
    <name>R4W9M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447687.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14270"/>
    <dbReference type="EnsemblBacteria" id="AGN02793">
        <property type="protein sequence ID" value="AGN02793"/>
        <property type="gene ID" value="L593_14270"/>
    </dbReference>
    <dbReference type="GeneID" id="16181037"/>
    <dbReference type="KEGG" id="sali:L593_14270"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149848_0_0_2"/>
    <dbReference type="OrthoDB" id="113511at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="26400" checksum="B7E2762CCC18015D" modified="2013-07-24" version="1">MQEQDEDPAAAVERLEDELEQRRQERRERLSTMPEAAKETAQDVGIQARSGVYVLKASPASLGTAWAVDESHLLTVAHTVQSADQEVDCWTLDGEQFSATVVDLVEDRRPDVGLLETERTLSPLETGMSEALDPEDPLVQVGHPGNFGYWVLAAGPYLHHEQQHSFASEVPILIGNSGSPVLGLDGMVVGISSYATISPEQEAAWGAPVRNETVLHEPVRPVITTYHVPIESALDRMEAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R7</accession>
    <name>R4W9R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446603.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01709">
        <property type="protein sequence ID" value="AGN01709"/>
        <property type="gene ID" value="L593_08820"/>
    </dbReference>
    <dbReference type="GeneID" id="16180235"/>
    <dbReference type="KEGG" id="sali:L593_08820"/>
    <dbReference type="HOGENOM" id="CLU_2839521_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="6919" checksum="1F9CD3C52BDCEF69" modified="2013-07-24" version="1">MEPLTLLQSIPEPLDTQFGRLLIALLVVAVIVVVGRAVLSLAWKLLWIAIVVVGALFGLSILGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T2</accession>
    <name>R4W9T2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="13" type="ORF">L593_09045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446648.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09045"/>
    <dbReference type="EnsemblBacteria" id="AGN01754">
        <property type="protein sequence ID" value="AGN01754"/>
        <property type="gene ID" value="L593_09045"/>
    </dbReference>
    <dbReference type="GeneID" id="16181947"/>
    <dbReference type="KEGG" id="sali:L593_09045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1855"/>
    <dbReference type="eggNOG" id="arCOG04393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_2_2_2"/>
    <dbReference type="OrthoDB" id="86833at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="12">
        <location>
            <begin position="124"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="28117" checksum="7020E3F221B4AF0F" modified="2013-07-24" version="1">MTEPTRVAIPGATGRMGEELLAEAAGRDDVEVVLATTRSPEAGPIAGVELAGADGLPALLTERDVDVLVDFTVPEPCIEAVEAAADADVDVVVGTTGFDSTETAALREASERTALLKAANFARGVQALLQVVGEAASAMEGYDAELIETHHNGKRDAPSGTAKAILHELEGAREAGDRDGGDRDGATDGDRVHGREGHAPRRDGEVGVHAVRAGDITGIHEVLLAGNHEELRLTHRAEDRGVFAAGALDAAVWLDGQPPGWYDFGDVLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T3</accession>
    <name>R4W9T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_15170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447862.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15170"/>
    <dbReference type="EnsemblBacteria" id="AGN02968">
        <property type="protein sequence ID" value="AGN02968"/>
        <property type="gene ID" value="L593_15170"/>
    </dbReference>
    <dbReference type="GeneID" id="16181782"/>
    <dbReference type="KEGG" id="sali:L593_15170"/>
    <dbReference type="eggNOG" id="arCOG04645">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1639912_0_0_2"/>
    <dbReference type="OrthoDB" id="117194at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16024" checksum="34726EAD610080A4" modified="2013-07-24" version="1">MSVAERTREAVRADPALYDALRAGVVNYSAAARSLAVDGDVESIATALRRYAEELPTGEQSDRRVSVRLHRGVALDEDAFGGVDLEADGDATAIQVTGDVDARAFERVLGSLRTAGVAVTAGGFNDDALVVGVEPRTGPEALRVVERALESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T9</accession>
    <name>R4W9T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446678.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09195"/>
    <dbReference type="EnsemblBacteria" id="AGN01784">
        <property type="protein sequence ID" value="AGN01784"/>
        <property type="gene ID" value="L593_09195"/>
    </dbReference>
    <dbReference type="GeneID" id="16182654"/>
    <dbReference type="KEGG" id="sali:L593_09195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1887"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OrthoDB" id="106121at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10641" checksum="266E050D7E782302" modified="2013-07-24" version="1">MEAALWYVLTGTRGGTNRVRLLRAMDERPRNANQLADDLDLDYKTVRHHLEVLVDNGVVENSGDDYGAVYLPTDSARHHWDTIEEIMEQVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V6</accession>
    <name>R4W9V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446763.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01869">
        <property type="protein sequence ID" value="AGN01869"/>
        <property type="gene ID" value="L593_09620"/>
    </dbReference>
    <dbReference type="GeneID" id="16182571"/>
    <dbReference type="KEGG" id="sali:L593_09620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1981"/>
    <dbReference type="eggNOG" id="arCOG09076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357963_0_0_2"/>
    <dbReference type="OrthoDB" id="127357at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="20463" checksum="BB80076D5D71815A" modified="2013-07-24" version="1">MIGRKLLAVALAATLLVGGVAASGAAMPQDVSPANDHAQNDSSADADVPDNSTEYDGNDSAAEHGNDSAAEHRNGSAPADAGPDGEQGPPTDMPEQVPDHVVQIHQTINDFLTGEVDDLGAAISDIVGDDAGDADEDAESDDGDSDDAQETEDAENAESEDGETDDADETEDADDTESEDTDAEDADADDGSDDSDDDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z7</accession>
    <name>R4W9Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_10645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446968.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10645"/>
    <dbReference type="EnsemblBacteria" id="AGN02074">
        <property type="protein sequence ID" value="AGN02074"/>
        <property type="gene ID" value="L593_10645"/>
    </dbReference>
    <dbReference type="GeneID" id="16181389"/>
    <dbReference type="KEGG" id="sali:L593_10645"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OrthoDB" id="58511at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="31837" checksum="BD371645DB5CC86C" modified="2013-07-24" version="1">MTTALLAAGVLQLADRLADIGPELIDEYWPLVKRLGWFLGVALLVTVPGWYLLVPSVSRIVRHRNRNNPTLEQAIARHLRLIVVVFGIAVGAAVAGFTGFLTDSAIVIAAATLALGVAAQSVVGSFVSGTVLVADPEFNVGDYVKWADGEGTIRSITLRVTRVQTPDGELVTIPNDVLTKQEITRPFGHGHFQVVQYVSLSYDDDLEAALAGLETAAEGLEQSLDAPSPQVYVDEFGGDAIVARVHYWIDEPDRREVFAARSTFARSAKQRLEAAGLTIAPAAKRNLQGAIEVADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z9</accession>
    <name>R4W9Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446978.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10695"/>
    <dbReference type="EnsemblBacteria" id="AGN02084">
        <property type="protein sequence ID" value="AGN02084"/>
        <property type="gene ID" value="L593_10695"/>
    </dbReference>
    <dbReference type="GeneID" id="16181401"/>
    <dbReference type="KEGG" id="sali:L593_10695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2205"/>
    <dbReference type="eggNOG" id="arCOG01042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131306_0_0_2"/>
    <dbReference type="OrthoDB" id="104786at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="16226" checksum="61C7D3254603C3B7" modified="2013-07-24" version="1">MASVPFHYVDLRTFVYATEHEQRVEDALRHFLPEDAELERQATEGHLGDRILVLSTRLENADDVRHVLSVVAESDDFGTLEDELDHRVTDNCELFVSLDKQAAFGGETRLGDGITLRAKVEAYPAKREAAVENAAEALQQFQDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA29</accession>
    <name>R4WA29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447128.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11445"/>
    <dbReference type="EnsemblBacteria" id="AGN02234">
        <property type="protein sequence ID" value="AGN02234"/>
        <property type="gene ID" value="L593_11445"/>
    </dbReference>
    <dbReference type="GeneID" id="16182056"/>
    <dbReference type="KEGG" id="sali:L593_11445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2361"/>
    <dbReference type="eggNOG" id="arCOG02100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_0_2"/>
    <dbReference type="OrthoDB" id="110491at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15792" checksum="C64AA19D642B29C7" modified="2013-07-24" version="1">MNTADQYLKAIYLAQRLEDGPAATGTLADMLDVSPASVNEMIGKLESRGLVDHEKYAGATLTDDGIVRAEDTLQTYCIIERFLHNVLEVEDFRGEARALESVIDDTVAERLDTIIDRRGECPDCFDAEADCCEFLEVEQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA41</accession>
    <name>R4WA41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447188.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11755"/>
    <dbReference type="EnsemblBacteria" id="AGN02294">
        <property type="protein sequence ID" value="AGN02294"/>
        <property type="gene ID" value="L593_11755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181147"/>
    <dbReference type="KEGG" id="sali:L593_11755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2419"/>
    <dbReference type="eggNOG" id="arCOG04280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_2"/>
    <dbReference type="OrthoDB" id="61440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="33821" checksum="2B5B24DA9F0EEE06" modified="2013-07-24" version="1">MYFAGVDLGATNTHVAVADDEGEIVGEDVRPTPRGPTGIAVTEEILDALRTAAGRAGVAPESIAAAGIGSIGPLDLAEGTIEDPANLPDNIGTIPLTGPIGNLIDSDEVHLHNDTNAGVIGERFFSDRNPDDMVYLTISSGIGAGVCVDGNVLDGWDGNAGEVGHMMLDPMGHLTCGCGSDGHWEAYCSGNNIPKYAKFLHEDDPIETDVPLDDPDFSAADVFEHAGSDEFADHVVDQVAHWNAMGVTNVVHAYAPIVIYVGGAVAINNPELTLEPIRERLDDMVFTNIPDVTLTTLGDDVVVKGAVASAMTGGTGDRRRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA72</accession>
    <name>R4WA72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447343.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12550"/>
    <dbReference type="EnsemblBacteria" id="AGN02449">
        <property type="protein sequence ID" value="AGN02449"/>
        <property type="gene ID" value="L593_12550"/>
    </dbReference>
    <dbReference type="GeneID" id="16180033"/>
    <dbReference type="KEGG" id="sali:L593_12550"/>
    <dbReference type="eggNOG" id="arCOG00245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077586_0_0_2"/>
    <dbReference type="OrthoDB" id="117835at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="269" mass="27061" checksum="C52529713BBBA1E2" modified="2013-07-24" version="1">MELLVVGAGTMGRWFARTVDAEVAFADRDPEAAAEAAAAVGGSTAALDGAESFDVVAIAVPMSAAEDAIAGQAGRARHAVLDVTGEMGTALDAMATQAPELERASLHPLFAPENAPGSVAVVVDAAGPEIDAVLADLEAAGNELFATTPEEHDTAMESVQAAAHAAIVAYGLARESVPDGFATPVSAALDDVLEQVTKGDPGVYAEIQDRFDGADAVAEAAAAVADADPAELRELVVEARPELAADGDGSEENASARADDQSAAPEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE5</accession>
    <name>R4WAE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447708.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14375"/>
    <dbReference type="EnsemblBacteria" id="AGN02814">
        <property type="protein sequence ID" value="AGN02814"/>
        <property type="gene ID" value="L593_14375"/>
    </dbReference>
    <dbReference type="GeneID" id="16181216"/>
    <dbReference type="KEGG" id="sali:L593_14375"/>
    <dbReference type="eggNOG" id="arCOG06787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130793_0_0_2"/>
    <dbReference type="OrthoDB" id="92119at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="14591" checksum="9EB9F586A7E0B408" modified="2013-07-24" version="1">MPSHRANHYGTACEKRMAAKRRFDLERSSWHDATFQNGTPVEIKSTRIEHSDGQPGNFKFYRAYHEKLRRHDGWYCFVVYRPTRSGLTVVNDRMRRGVDLPCLRWHGGGDHRGTEQAKLAISDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS34</accession>
    <name>R4VS34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444924.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00375"/>
    <dbReference type="EnsemblBacteria" id="AGN00030">
        <property type="protein sequence ID" value="AGN00030"/>
        <property type="gene ID" value="L593_00375"/>
    </dbReference>
    <dbReference type="GeneID" id="16179950"/>
    <dbReference type="KEGG" id="sali:L593_00375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.75"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14997" checksum="87CB84E5AE27ECD5" modified="2013-07-24" version="1">MYDTVLVATDGSGPATRAVTHALEQAERSNAELHAIYVVDTARYAEPALSSAELATTEMEEWGQQELDEVAERAESLDVDVLTRSCHGRPYIEIIEYADTIDADLIVVGYQGHSHSDPGQIGSVTDRVVSNAGRPVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTH0</accession>
    <name>R4VTH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445414.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02845"/>
    <dbReference type="EnsemblBacteria" id="AGN00520">
        <property type="protein sequence ID" value="AGN00520"/>
        <property type="gene ID" value="L593_02845"/>
    </dbReference>
    <dbReference type="GeneID" id="16182758"/>
    <dbReference type="KEGG" id="sali:L593_02845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.575"/>
    <dbReference type="eggNOG" id="arCOG01931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089193_0_0_2"/>
    <dbReference type="OrthoDB" id="60774at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="278" mass="31085" checksum="615F2BDF1F70429B" modified="2013-07-24" version="1">MLELEHGFRVVDVHARLSVDEDVAARGRMISPDRLEREMRQAGVVRAVVVPETNPESRYLQFNNAVARLSVERPFVAFARLSGPRSLSESATNRLRSAVSGRDDHHTDPDEIEQYAYDDRFHGFVMDPARDGLPDEQTLDELEEVDLPVLVPGGEAFPPERIAETLLDRSFPTIVGHFGGHPLQRDLMGRAIDLLGEYDGYYLDTSLVRYREPLERALLEHPDRVLFGSGAPASHPNVGVMELLTLDVSEDKLRRAFDRNPSRVVDALAPEEEGAPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTJ8</accession>
    <name>R4VTJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00560">
        <property type="protein sequence ID" value="AGN00560"/>
        <property type="gene ID" value="L593_03045"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03045"/>
    <dbReference type="eggNOG" id="arCOG13157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032956_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="121" mass="13685" checksum="8881C4EFE0041DED" modified="2013-07-24" version="1">MNSKALFGGLVAVLLCLGLVMMFIAPIFDDDADCRRTTHVYEDPDEVEGISFSSGHSTHYDYANMSSDAQSIFDRAREDGDYQFYDASDDPPEFEYSDEVQFYTVSYRNDTYYLWTGGCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTW5</accession>
    <name>R4VTW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445559.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03570"/>
    <dbReference type="EnsemblBacteria" id="AGN00665">
        <property type="protein sequence ID" value="AGN00665"/>
        <property type="gene ID" value="L593_03570"/>
    </dbReference>
    <dbReference type="GeneID" id="16180601"/>
    <dbReference type="KEGG" id="sali:L593_03570"/>
    <dbReference type="eggNOG" id="arCOG08999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010545_0_0_2"/>
    <dbReference type="OrthoDB" id="58169at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="275" mass="28429" checksum="9F364B99AECCACD3" modified="2013-07-24" version="1">MSADADASSGAATGRPGGETGRPGDETAADSLRRTGFAAWIEAVQVRRDPLLLVLLVALPAYFVGAWGVIVPDATMTASIPSGEGAQTVQASMPELIVAIIAPVAGALVVGITALFVVQRSRDVDGRLQIAGYRPVELLAARLSLLGGIAVLVTVVTIAASWIHLVPEHPLWFGLAVMLAGGIYGAIGAMLGLVLDRMPGVYSLLFAPIIDVMILQSPLSEQPWWTAWLPGHHPAQLAASAALADSVAIEHAAGGLAALLVLVGVVGVVTTYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUT6</accession>
    <name>R4VUT6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl18e</name>
        <name evidence="6" type="ORF">L593_05230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445889.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05230"/>
    <dbReference type="EnsemblBacteria" id="AGN00995">
        <property type="protein sequence ID" value="AGN00995"/>
        <property type="gene ID" value="L593_05230"/>
    </dbReference>
    <dbReference type="GeneID" id="16181281"/>
    <dbReference type="KEGG" id="sali:L593_05230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1068"/>
    <dbReference type="eggNOG" id="arCOG00780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OrthoDB" id="104254at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_L18/L18-A/B/e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="12619" checksum="5C2B832BE45F688F" modified="2013-07-24" version="1">MSKTNPRLTSLVADLKSAARETDADVWSDVADRLQKPRRTHAEVNLGRIERYADEDETVVVPGKVLGSGSLRKAVTVAAVDFSSSAQTKIEQVGETTTLEQAIQNNPEGSNVRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV28</accession>
    <name>R4VV28_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">L593_05730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445989.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05730"/>
    <dbReference type="EnsemblBacteria" id="AGN01095">
        <property type="protein sequence ID" value="AGN01095"/>
        <property type="gene ID" value="L593_05730"/>
    </dbReference>
    <dbReference type="GeneID" id="16181481"/>
    <dbReference type="KEGG" id="sali:L593_05730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1173"/>
    <dbReference type="eggNOG" id="arCOG01303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_2"/>
    <dbReference type="OrthoDB" id="96879at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="14165" checksum="7B1E858E918A822A" modified="2013-07-24" version="1">MSFDVPDDRRYLDSHEWAAQDDGVVRIGISDFAQDELGDVVFVEFPDEGESITAGEAFGVVESIKAVSDLYAPVSGEVVEVNETLFDRPELVNDDPYEEGWMLAVEPSEESELAELLDADTYREQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV65</accession>
    <name>R4VV65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_01040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445055.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01040"/>
    <dbReference type="EnsemblBacteria" id="AGN00161">
        <property type="protein sequence ID" value="AGN00161"/>
        <property type="gene ID" value="L593_01040"/>
    </dbReference>
    <dbReference type="GeneID" id="16180219"/>
    <dbReference type="KEGG" id="sali:L593_01040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.213"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_2_0_2"/>
    <dbReference type="OrthoDB" id="24701at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="301"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="654" mass="70399" checksum="9257609D85B07215" modified="2013-07-24" version="1">MVVDSDSIERVGVIGAGNMGHGIAEVVALAGYEVVMRDVEEDLVRDGYEDIEWSLNKLAEKGIVDQSPDAVLERIDTTTDLAAAADGADLVIEAAPEQLSIKHDIFEELDEAAPEDAILASNTSSLSITTIAEGTERPDQVLGLHFFNPPVKMDLVEVIYGEGTSDATADAGYEFVESIGKTPIRVRKDVHGFVVNSVLGPFASEPAWMVSRDEATIRGADATMVHERGYPMGPFELADMNGIDIGYHVRKEADIPIPPIMQERVDAGNLGRKSGAGYYDYEDGDGADYGPDDAGDFDWFRVEAMMVNEGAKLVGNDVATPEAVDTGMRLGAGFPEGICRRGDALGLDDVLEKLQELHETYGDERYEPDGYLVDLVEAGHTGEEAGRGFYEYDAGDGPGEYSTINWALEDDGLLEIEFDRPERLNAMNGDLADAVVDLLDSIDEDAVRAVTFEGAGDRAFCAGADITGFASIEPAKQSEPTPVYGTIAEFPRPTLAKIDGYCLGAGLEMALACDLRIATTDSEFGFPEINLGLLPGGGGTQRTMRMIGDARAKELVFRGEHIAAERAENWGLINRAVDPADYDDVVAAFVHDLVTGPPIALRKAKRVMNEGRDQDLDAALDMESQAFALLLTTDDAKEGAAAFAEDREPEFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVA7</accession>
    <name>R4VVA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01165">
        <property type="protein sequence ID" value="AGN01165"/>
        <property type="gene ID" value="L593_06080"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06080"/>
    <dbReference type="HOGENOM" id="CLU_2839520_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="8024" checksum="2DA5D74205636F2E" modified="2013-07-24" version="1">MSDQEQEFRRQPYNRVKQKMEHINRMVDKIKYADHSDDTRRTLYEHKRILEENLQEFLGVDEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVH8</accession>
    <name>R4VVH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445145.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01490"/>
    <dbReference type="EnsemblBacteria" id="AGN00251">
        <property type="protein sequence ID" value="AGN00251"/>
        <property type="gene ID" value="L593_01490"/>
    </dbReference>
    <dbReference type="GeneID" id="16179828"/>
    <dbReference type="KEGG" id="sali:L593_01490"/>
    <dbReference type="eggNOG" id="arCOG08959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534767_0_0_2"/>
    <dbReference type="OrthoDB" id="122941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="80" mass="8895" checksum="1AA8FA9915F2F86E" modified="2013-07-24" version="1">MPLRKAWNDLTRTTVGKAPERYGVYEVGDADGEVLEVGAGVLKDELKEALAYGAGEQVRWEPTPSLERAEELAAEHRERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVL7</accession>
    <name>R4VVL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445190.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01715"/>
    <dbReference type="EnsemblBacteria" id="AGN00296">
        <property type="protein sequence ID" value="AGN00296"/>
        <property type="gene ID" value="L593_01715"/>
    </dbReference>
    <dbReference type="GeneID" id="16179932"/>
    <dbReference type="KEGG" id="sali:L593_01715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.348"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OrthoDB" id="67908at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="27575" checksum="9EC6F488AF9B9881" modified="2013-07-24" version="1">MDLGLDGNAALVTASTSGLGLASAHALAREGANVSICGRTESRLDEAKETIEADAAGNVMARQVDVTDPDEVRALVETTAEAYGGIDHVVTSAGGVPSGSFLDMEDRDWYQAYDTLVMSHVWTLRAAHPHLVESDAGSITSITSTSVQEAIDGLVLSNAVRRAVVGTIDTVAREWAPGIRANVVMPGAHETPRIEELIEQALDRGEYDSYEEGLTDWAAPIPLDRIGDPMELGDVVAFLASERASFVTGATIPIDGGRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVP8</accession>
    <name>R4VVP8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_06640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446169.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06640"/>
    <dbReference type="EnsemblBacteria" id="AGN01275">
        <property type="protein sequence ID" value="AGN01275"/>
        <property type="gene ID" value="L593_06640"/>
    </dbReference>
    <dbReference type="GeneID" id="16180836"/>
    <dbReference type="KEGG" id="sali:L593_06640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1355"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_0_0_2"/>
    <dbReference type="OrthoDB" id="95722at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="9">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="10">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="16722" checksum="04C83D7FEAB5B2C3" modified="2013-07-24" version="1">MAVVSVSMPDELLDRLDEFSEEHGYTGRSEVVREASRNLLGEFEDASLEDKELMGVVTVVFDYETTNVEQRMTELRHEHEHLVASNFHSHVAERYCMELFVLEGTLPEISTFVGKIRATHDTLSVDYSVHPIEEFSQTLEAAEEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVW1</accession>
    <name>R4VVW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446239.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06990"/>
    <dbReference type="EnsemblBacteria" id="AGN01345">
        <property type="protein sequence ID" value="AGN01345"/>
        <property type="gene ID" value="L593_06990"/>
    </dbReference>
    <dbReference type="GeneID" id="16181958"/>
    <dbReference type="KEGG" id="sali:L593_06990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1429"/>
    <dbReference type="eggNOG" id="arCOG03129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073248_0_0_2"/>
    <dbReference type="OrthoDB" id="57641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="28056" checksum="7F4A16DF5C6B857C" modified="2013-07-24" version="1">MQVVDYVRTGHEGGPALLLADESGDLERLALDHGTELAYTLDERHCAGTLADGTHEACDAPATPYCDAHTHTWVCARCTGDCLKPEMDCHGEHAIYVAAFAPDVHKVGVTYLDRLPTRLQEQGADRAAHVRTVANGRIARELEAAIAERIPDRVRVPTKIAGLHDDVDVPAFEATLETELPPDFEVHEQFDFDYGLDLNAAPVPETTATGTVRGVKGRILVLEEHGTNYAVDLRDLLGYELAEGASDREKQASFGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW54</accession>
    <name>R4VW54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446344.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01450">
        <property type="protein sequence ID" value="AGN01450"/>
        <property type="gene ID" value="L593_07525"/>
    </dbReference>
    <dbReference type="GeneID" id="16182141"/>
    <dbReference type="KEGG" id="sali:L593_07525"/>
    <dbReference type="eggNOG" id="arCOG06340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190403_0_0_2"/>
    <dbReference type="OrthoDB" id="128002at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="8914" checksum="35DB80379F2348E0" modified="2013-07-24" version="1">MLERERLIEIAVSVGGVGVMVALLYYIGSTHTSEANGHQVLSPSGGELVVYSIIAFIVLMAIVGVVLIQTVTVPEARADDGDSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWC2</accession>
    <name>R4VWC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L593_03125</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03125"/>
    <dbReference type="EnsemblBacteria" id="AGN00576">
        <property type="protein sequence ID" value="AGN00576"/>
        <property type="gene ID" value="L593_03125"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.632"/>
    <dbReference type="eggNOG" id="arCOG00795">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="PTHR10887:SF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dna2" evidence="13">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="14">
        <location>
            <begin position="562"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="14">
        <location>
            <begin position="662"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="15">
        <location>
            <begin position="743"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AGN00576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="968" mass="104709" checksum="007068DA24424EDD" modified="2013-07-24" version="1">MLRGRVLEIGDVREVTTQRGTSELVEVTLRSDEYGPVTVTLWNRWTETAAYLEPGMELGVTDPDWGEPPEPIADESDAAAESAGSDGENVPSGPGASGDGSGPTPDGGTTAEPGTDTVQSASTTPDSLVVVEPDFLVDVTDVREWVQCPRQYYLSKIDDAELAEPLVLGTIVHEVFGDLLRGVDVEAAVDDRIEGAGLNLGLLGLDPDAVTDTVTKHAEAIQGWLNQGTLTDGDDWRSEQLLISERLGLKGRADAVRRGMPVELKTGKNTRSDPRFHDKIQAALYALMLRERGVPVDTGILLYTKNATLDRAETGGDLSPAKEFALNDGLLDFALRSRNELAAMEADVSVPTGHEADANCDRCFVQDTCMVVAGRLGQESKAGAIGRQVPDAERDYFDAFYRAIELERRAIHDEYRKLWEQTPAERAADDRALVDLQFEGKEPLPGGRWRLTARRPSAAVSKLREGDFALASDGDPIEGHAEFCRIQRLDPELVVVTADEPVELTRLDQYPSEITADRMLSALMDGILKGDQRRKDVLFERADPEFDDALLGEDGPQFVPNNDAQNGAVQRAVAAEDFSLIHGPPGTGKTYTIARLVRALVDRGDRVLLSAFTNRAVDNALEALHDQGFDDAIRVGSANGVREDMQDVRLERRGDPDELVDALESAPVVAATAASCGSTVMSEQAFDVAVVDEASQLTEPGTLAAIERADRFVLVGDHEQLPPVVQAESGPQEAPSTPFEVDLSRSLFQRLLETSPEAGVSLEEQYRMAQAIQAFSSREFYDGALRPATGEVAAHALADLDGVAADALPAELGDRVSFLDVGGDDAGRTDAVEAERIADLIDTYLDAGLDPRDVGVIAPYRAQVATIGDRLEDLLADRADRDADDPGDDVADESPIAVDTVDRFQGSSKEVIVVSFVATDDLDSPIFEDYRRVNVALTRAKRQLVLVGDADALRSDPVYARMVEWAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWG7</accession>
    <name>R4VWG7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_03375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445520.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03375"/>
    <dbReference type="EnsemblBacteria" id="AGN00626">
        <property type="protein sequence ID" value="AGN00626"/>
        <property type="gene ID" value="L593_03375"/>
    </dbReference>
    <dbReference type="GeneID" id="16180517"/>
    <dbReference type="KEGG" id="sali:L593_03375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.683"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_3_2"/>
    <dbReference type="OrthoDB" id="105892at2157"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="213" mass="22739" checksum="76F3B3A11D3E52BE" modified="2013-07-24" version="1">MTLFAFDFDGTLSDSEMTVLLGSQYGVADQMDSITEQAMNDEIEYAESLRQRAALLEDLPDEKAQAAFEEVVLRPGAAEVIADLREAGHHVAILTGGFERGVAEALTKEGVDVDTIVANRLPVEDDALTGEVRGSLIEGTKDEALELLVDDQDLDIGDTVAVGDGANDLPMLQAAGWAIGFEPKEAVAPHCDVEVTTMEALRAELIAEGHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWJ3</accession>
    <name>R4VWJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03500"/>
    <dbReference type="EnsemblBacteria" id="AGN00651">
        <property type="protein sequence ID" value="AGN00651"/>
        <property type="gene ID" value="L593_03500"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.710"/>
    <dbReference type="eggNOG" id="arCOG00517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="391" mass="41353" checksum="7C06022BE374D014" modified="2013-07-24" version="1">MAESIEPVDLAERIARGERIGIVDVRNREEFEEWHVEGPAAEVSQIPHAQFLQAQVRGGAADLVADVPEPIVTVCAIGEASDHAAELLRDAGLDAMNLTGGMEAWADVLLARSLDAPDGAEIMQYQRPATGCLGYLVVDGEEAAVVDPLGAFADRYPDHAAESGAELRYAIDTHVHADHVSGVADVAERSDAEPAIPAGAWDRGFDSDLEYTALDDGDVLELGEQTTIRAIHAPGHTGEMTALLVERAGGSGAEPESGDRPGTLLTGDSLFVDGVARPDLEADVDPEEAAATLHETLQALRERLPSRTLVAPGHVKQQTEPTVDGTYVAELGTLAERLEAFDLDADAFVRSVTDDLPPPPANAERIVAANLGHEAIDDLDEIELGPNNCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWL2</accession>
    <name>R4VWL2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_08425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08425"/>
    <dbReference type="EnsemblBacteria" id="AGN01630">
        <property type="protein sequence ID" value="AGN01630"/>
        <property type="gene ID" value="L593_08425"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1726"/>
    <dbReference type="eggNOG" id="arCOG02322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="202"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="591" mass="61637" checksum="E64B7E97B49DB748" modified="2013-07-24" version="1">MLTPPVLAIVGVVAGCLLAVWAGTIALTGGSITLTNLAVLAGGQLAVVTVGLAVATTVPRGKLEPLEQAARDLQRGDRPADLPTDRDDEVGQVAAAMASLTADLADAEQRVVRAERRAEDRAAELTALSEALSAHAEAFEAAMDRAAAGDLTTRIEAEADDDRLATLAGEFDAMLAEIERTIDRLKRFSNDVAIHGEEVTASAAEVQHASEQVSTSVQEISETTETQSRTFERVAERIDELADATESIAVRAETVSRVAERTAETGQRGQEAARDAAMAMESIDASSASATEEMADLEALVDEIDEVAEFISEVAEEVNVLALNANIEASRSAADANEGFAVVAKEVKDLAAETKFSAQRIENLVGEVKVQTELAASEVQSTRDAVTEGRDTVEEAIDALAEIADYADETHEGVLAISEATDEQTSATDDVVSMVDHAAKLSREVDAEAGTVAAAAEQQTSALTEVSHGTGQLSTEAQSLRDALDRFQTAVEPEEASRGWLPEASTAGEGPRASDQPAPLQSGGARSAAPNAASRNEAGGGPDGDERTAASTDAPDRTTAADGDEQDAASSDGDWPGAWEPTVEPATHDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWP1</accession>
    <name>R4VWP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446554.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08575"/>
    <dbReference type="EnsemblBacteria" id="AGN01660">
        <property type="protein sequence ID" value="AGN01660"/>
        <property type="gene ID" value="L593_08575"/>
    </dbReference>
    <dbReference type="GeneID" id="16182460"/>
    <dbReference type="KEGG" id="sali:L593_08575"/>
    <dbReference type="eggNOG" id="arCOG06329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257440_0_0_2"/>
    <dbReference type="OrthoDB" id="112684at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11397" checksum="D16C828D7C3EDE7D" modified="2013-07-24" version="1">MELRNSEGSPIDPVPFLVVALLGICVAMAWGPLYLKSHGLGELLAIGVSGVLAVGTVGAAFYRFVWTENPNRREEVPVGERFRTLLYAMLLGILILLALIALLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWZ8</accession>
    <name>R4VWZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446629.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08950"/>
    <dbReference type="EnsemblBacteria" id="AGN01735">
        <property type="protein sequence ID" value="AGN01735"/>
        <property type="gene ID" value="L593_08950"/>
    </dbReference>
    <dbReference type="GeneID" id="16182583"/>
    <dbReference type="KEGG" id="sali:L593_08950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1836"/>
    <dbReference type="eggNOG" id="arCOG01912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105301_0_0_2"/>
    <dbReference type="OrthoDB" id="87487at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19013" checksum="4731BE56136E3193" modified="2013-07-24" version="1">MAVFGFELPLLLVLIGLGLMIAEALAPGANFIVLGVALLFAGMLGLVVAPLASPIALAGLTLLFGALALFLYREYDIYGGTAEQTSDSDSLRGATGRVVDRVTETDGRVKLDGGGFNPFYQARTVDREIAEGEEIIVVDPGGGNVVTVTALEGLEDDEIDRELARESEGGEPVGERESQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI0</accession>
    <name>R4VXI0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">L593_10075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446854.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10075"/>
    <dbReference type="EnsemblBacteria" id="AGN01960">
        <property type="protein sequence ID" value="AGN01960"/>
        <property type="gene ID" value="L593_10075"/>
    </dbReference>
    <dbReference type="GeneID" id="16182259"/>
    <dbReference type="KEGG" id="sali:L593_10075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2077"/>
    <dbReference type="eggNOG" id="arCOG01981">
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        <property type="entry name" value="TFIIB_cyclin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="60"/>
        </location>
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        <location>
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        </location>
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        <location>
            <position position="34"/>
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        <location>
            <position position="37"/>
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        </ligand>
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        <location>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="37319" checksum="D493F9A22B881185" modified="2013-07-24" version="1">MTEDDIRTRTARRDEQVETSDEQTTEEVDEELHCPECGGTLRSDEEHGETVCEDCGLVVESDEIDRGPEWRAFDSREKDEKSRVGAPTTKMMHDEGLSTNIGWQDKDAYGRQLSSRQREKMQRLRTWNERFRTRDSKERNLKQALGEIDRMASALGLPENVRETASVIYRRALDEDLLPGRSIEGVATASLYASARQAGTPRSLDELEEVSRVDKMELTRTYRYVVRELGLEVQPADPKQYVPRFVSDLGLSEEVERRARQLLDRAQDVGVHSGKSPVGLAAAAVYAASLLTNEKVTQNQVSDVADISEVTIRNRYKELLEAAEGDGSAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXJ3</accession>
    <name>R4VXJ3_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00981.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13406" checksum="3022B81E31B280C7" modified="2013-07-24" version="1">MLLVRGRAGGTELTGTIYERGERAPTFRGAPEDDAAYVWVCDEFYEVESGGSIQEIDGREIHVAFESPMPRGFDTRDQALAAAREHVRTQFSRVGVATTDVEIEVVEDAEVAADEGAPAEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXL6</accession>
    <name>R4VXL6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_10275</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2118"/>
    <dbReference type="eggNOG" id="arCOG02864">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:respiratory electron transport chain"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20374" checksum="CA5CCE14CB17312C" modified="2013-07-24" version="1">MLRAYLRDRVRAATAVLGTVSLALVFAAAGQRIPTALLPDAPDAVLDTIPHVNAAISLLAIATISLGWRAIRNGRVDRHRKLMVSSAGLFAAFLVLYLYRVSLLGPHGFPGPDAVYLYVYLPLLAIHILLAMVCVPLLWFVGLLGATRTVPEIRQSPHAKYGRIAASLWLISFSLGVVVYLLLYVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXT8</accession>
    <name>R4VXT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445970.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05635"/>
    <dbReference type="EnsemblBacteria" id="AGN01076">
        <property type="protein sequence ID" value="AGN01076"/>
        <property type="gene ID" value="L593_05635"/>
    </dbReference>
    <dbReference type="GeneID" id="16182076"/>
    <dbReference type="KEGG" id="sali:L593_05635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1153"/>
    <dbReference type="eggNOG" id="arCOG02278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269133_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="598"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="778"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134478" checksum="639EDC6019E619C3" modified="2013-07-24" version="1">MPPSALGSTDWHVLVSVVSLGGMAATSDVERLIEGVERVAAGDYDVAFELERDDELGRLASALEEMTAAIATRKADPTDADEPDPADREDELHRYARHFEAVFNDPNLLAVILDPDGTLREINDRAMGMIDADRESVLGEPFWETPWWEGDEALQAEIRSGIERAATHDEYVEYVADHDETETAAYTSEGVIRPVSDASGNVESLVVSARDITERREREEELREARDRLTKTNRALERLYQIGADRDASLEEKIQTLLDLGRERLDLSGGYLSSIDPEDDRFEFVQTSGLDTMSPGTVTSLTETYCNETITTGEVFAIADAPAEGWGEHPAYQRWGSAAYIGGRVYVEGELAGTLAFVDDDPAPSGFTAEQYTFVDLATQWVGYELERRRKSDRLVEYTSFIDDVLDTIEDVFYVVGPDSAFERWNQSLGEATGFSEEEIEGMEPLDFIAPEDRDALASALDEAYETGSARMEARVLTKDGEKVRYDFLGSVLEDPDGNEVLVGIGRDVSERAERQYELKRTKYLLDLAQRIAHVGGWELDVRSKPYVFEATDEFYRIHGATPADHVDVETVREFYHSDERRGIDRVMADAIENGESYDMEVRLATDGRGRRWVRAIGEPVTSDGEIVAVRGSVQDITEQKEQELTLESLHELSRGLLEVDSRPAVAARVRDAAVGVLDMPCVAVYLFEESTGRLEPAAVSEAFETVCRDEGVGFDAEDDSLVWESYVSGEAIEIDDPAQDNSPILEASDHAGMLVPIGEYGVLLLASGRDAPDADDRRLAETLVATMETALQRLDNEVALRSQQSQLETQNRRLRRQIQITEIIRRVDRSLVGASSRDEVESAVCERLVESDDAAFAWIGALDEQGAELVPRTWAGIGHEYLDAISLSTSSETPDPAVQTAVSGDPTVVESIVEGVTTEHWRKHALVWQFSSAIAVPLELDEYSYGVLAVYGTEPGAFGDLERSVLQDLGGTIANAINAVEARRALYADEFVELRLRLEEEADFLGQLAAASGARVEYVGLATHGEHESRLFFETSGVAAETVRDALEDLHSVVEFRRIGEAEEPTLFEATVAGTVLAASLVGRGGVPRSMVASGGDLSVVVDVPTTTEVREFLDMLRERYSSVQLIGRRNVRRDVQTRQELVAGLFDELTERQLEVLRTAFFAGFFEWPRESTGEDVAELLDVSQPTVNRHLRHALAALLQVMFEEEPTAIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXX2</accession>
    <name>R4VXX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447014.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10875"/>
    <dbReference type="EnsemblBacteria" id="AGN02120">
        <property type="protein sequence ID" value="AGN02120"/>
        <property type="gene ID" value="L593_10875"/>
    </dbReference>
    <dbReference type="GeneID" id="16180562"/>
    <dbReference type="KEGG" id="sali:L593_10875"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764196_0_0_2"/>
    <dbReference type="OrthoDB" id="74110at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41156" checksum="169246D1C456A3AC" modified="2013-07-24" version="1">MGRLVHTADVHLHPDAPERRQALEALLDRAESTDADAVTIGGDLFEDEVAAERLRPELRSLFSDRPYPVVLIPGNHDREAYEGDVFFGAAVRTATVEPFEHVLVERDAAGSGGNDLVSRITCVPYTRELDDDLLVALRDREPFDGPEYLLVHCSLEAPAATADTGDEEAARYAPVTRSELGALEFDAVLAGHYHGANRVGLPASSAESNAADAGGTFVYPGTPASVTTAETGRRSIAIVDDGATPSVALEPLDSFHYDELELTVRPGDAKDAIGTVREQVATWAHRDVEAEIAIEGFVDRDEAMFAAELADAAGDVPLENRTRSVAHLLDHPIYREFEARIDADTALDATENEGHDPDQLLDDARERVLAAMADLAAEGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY10</accession>
    <name>R4VY10_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ORF">L593_05985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446040.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05985"/>
    <dbReference type="EnsemblBacteria" id="AGN01146">
        <property type="protein sequence ID" value="AGN01146"/>
        <property type="gene ID" value="L593_05985"/>
    </dbReference>
    <dbReference type="GeneID" id="16181559"/>
    <dbReference type="KEGG" id="sali:L593_05985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1226"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OrthoDB" id="32191at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="46836" checksum="FFE9A0ECE5533498" modified="2013-07-24" version="1">MGSTEKSNTEDYGDRQKYEFKKVIEELEEYEGSGTQLVSIYIPGGTRISEVQAHVTQEHSEASNIKSKQTRTNVQDALSSIKSRLQYYEEAPENGMVLFSGAIDAGGGQTDMVTKVLESPPDPIESFRYHCDSNFLTGPLEYMLADKGLYGLIVLDRREANVGWLKGKRVEPVKSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMANELFVPDRHEMDGILVGGPSPTKDEFLDGDYLHHELQDLVLGKFDVSYTDESGLHDLVDNASEALADAEIMQDKEHMETFFKQLHEGEEATYGFDATRQNLMMGSVETLLLSEDLRQDVVVADCDACGNTTYELVDRRHATPGSVDCEDCGETVEVSEEDREDVIEHLMAIAEQRGTETAFISTDFEKGEQLMDAFGGIAGLLRYSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY91</accession>
    <name>R4VY91_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11350"/>
    <dbReference type="EnsemblBacteria" id="AGN02215">
        <property type="protein sequence ID" value="AGN02215"/>
        <property type="gene ID" value="L593_11350"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2341"/>
    <dbReference type="eggNOG" id="arCOG06897">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034084_2_1_2"/>
    <dbReference type="OrthoDB" id="44157at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="119"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="392" mass="43450" checksum="F5E1E3B8C4F69EBB" modified="2013-07-24" version="1">MTSVLLPTGREASTYACVRSLAAKGIEPIVVSEKGGVPAAASRFVERTEPLPDPRDDFLAYRDALLALAERFDVDSIYPLRPEDGYLLSRYVQQFEAHVSLVVPPMDALERVHDRLALAAAAEAAGVPVPETKSLDDVDDWSGRHVVKSRYNVLADAYFPDRSPEDVDVVKAIEHLPPAVEPDRAETVAAFDHVPIVQEFVPKDGEYMVAALYDHGDPVATFQHLQIRGDSYTGGGGVYRRSIRDPELASVAHDLLAELEWHGLACIEYMRDARTGEYVLTEINPRFWQSLPSTVRAGADFPWYYYLLATGRGDEIEPSYRTGLGSHLLHGELGHLMSVRSDESPLVDRPSFVGTAAAIAGSCLVEPRFDYLRLDDPAPFLHGIRTKLRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYA5</accession>
    <name>R4VYA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447129.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11450"/>
    <dbReference type="EnsemblBacteria" id="AGN02235">
        <property type="protein sequence ID" value="AGN02235"/>
        <property type="gene ID" value="L593_11450"/>
    </dbReference>
    <dbReference type="GeneID" id="16179966"/>
    <dbReference type="KEGG" id="sali:L593_11450"/>
    <dbReference type="eggNOG" id="arCOG03898">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122599_0_0_2"/>
    <dbReference type="OrthoDB" id="82902at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="27686" checksum="1F4EC15E64C7B3DF" modified="2013-07-24" version="1">MECPTCGRDSFTEAGVRQHHSKIHDEPLPNRTCSGCGTQFYDPKARLEYCDDCNPNAGSNNGNWSGAMETTRCSECGDRFEFYPSEKDGVYCSSCIDATDGLLPDNPMEPIDRVVISCPACGEELRVLQSLLDRRKRGVFCGLDCYGDWLSEHIVGPDHHQWTGSCPEYGHGWSAVRRAARVRDEYECQICGTSKVDMGRNPDVHHIVPVREFPDPGDAHCLENVITLCRSCHRKAETGSIAVPDPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYB6</accession>
    <name>R4VYB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446105.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01211">
        <property type="protein sequence ID" value="AGN01211"/>
        <property type="gene ID" value="L593_06320"/>
    </dbReference>
    <dbReference type="GeneID" id="16180859"/>
    <dbReference type="KEGG" id="sali:L593_06320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1289"/>
    <dbReference type="eggNOG" id="arCOG08149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955164_0_0_2"/>
    <dbReference type="OrthoDB" id="66589at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="294" mass="33973" checksum="1F84741418C20E15" modified="2013-07-24" version="1">MDRLVHYHHPCDDTFSLAYCGESPADLDDYRSDADGPTKSLGYPFETPVYLLFEGTHSAKTASDLEYDSDFVEDQIAGQPRPTQIVAFRLIELLEAAVDVREEDEFRLYKEFEPEQIHEALQNVSWGEVLPTVAGELLSNLVLRHSLPNANHRTGIALAQLCIETVDPSFKMPSTHVDDETWKEWIDPYIVESKRIITVRRNNVRFKHLAELDVDLVERKGGIRIRLSDYELDMYPREALRKYAKIHEEHCVDLITELLKRADRSDLITQSGPTKEEFVEYLDTGVDRDFRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYJ4</accession>
    <name>R4VYJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446195.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06770"/>
    <dbReference type="EnsemblBacteria" id="AGN01301">
        <property type="protein sequence ID" value="AGN01301"/>
        <property type="gene ID" value="L593_06770"/>
    </dbReference>
    <dbReference type="GeneID" id="16181423"/>
    <dbReference type="KEGG" id="sali:L593_06770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1383"/>
    <dbReference type="eggNOG" id="arCOG04150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_3_0_2"/>
    <dbReference type="OrthoDB" id="80501at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="20359" checksum="517C46A53BF0D931" modified="2013-07-24" version="1">MQHVKIPQDRIGVLIGDGGETLREIEAKADVRLDVDSENGAVKIDQQGDADPVRALKGPDIVKAIGRGFHPEDALALLDDEMMMFDLVDIDAATRNRNDLTRKKGRLIGEDGRTRELMEELTGASVVIYGSTLGAIGTPQQVDAVRQAAEMIIDGAPHGTVYAFLEDKHQEIKREGLEYHRFPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYR8</accession>
    <name>R4VYR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoesterase PA-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446280.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07195"/>
    <dbReference type="EnsemblBacteria" id="AGN01386">
        <property type="protein sequence ID" value="AGN01386"/>
        <property type="gene ID" value="L593_07195"/>
    </dbReference>
    <dbReference type="GeneID" id="16182060"/>
    <dbReference type="KEGG" id="sali:L593_07195"/>
    <dbReference type="eggNOG" id="arCOG03951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082638_0_0_2"/>
    <dbReference type="OrthoDB" id="57852at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="6">
        <location>
            <begin position="150"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="31007" checksum="7481640399A061C6" modified="2013-07-24" version="1">MPVVPWEVIGYTLGPTIAVVVVFAVLTGWHRHAKTAMAGDLRGRAIELSPYAGVLVLVLLLNAFVRPRVDEFSSAFAIAFTDNIQGFEGNFVALLQDAIPEPMFLYFSAVYVVGYGALLLYPPIAYVVIDDLLKPAMLFVAYAVNYFTGALLYVVFAVYGPRNLQVGRVEAPLFEEFPDIMYLTSAINTNSNAFPSLHTSMAVTVLIFAWFTREEYPIWTVIASILAPSVVLATMALGIHWFTDVIAGVALAVFSVGAAQWIVPRVRGEVDDDRRPLDPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYS6</accession>
    <name>R4VYS6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447309.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12380"/>
    <dbReference type="EnsemblBacteria" id="AGN02415">
        <property type="protein sequence ID" value="AGN02415"/>
        <property type="gene ID" value="L593_12380"/>
    </dbReference>
    <dbReference type="GeneID" id="16179898"/>
    <dbReference type="KEGG" id="sali:L593_12380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2546"/>
    <dbReference type="eggNOG" id="arCOG02860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_6_0_2"/>
    <dbReference type="OrthoDB" id="113895at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="25705" checksum="C365F3BB379B1CD3" modified="2013-07-24" version="1">MPDATLADLLDRNDRHVESLQAGYFDDVEDGQSPAVVSMCCSDSRVSQEAMWDVEEPGWLFTPSTIGNQVWDRVDGELVLDGSFCYPMAFTDTEVAVVVGHTGCGAVTAALEAVQGAGDATDEDADSTPAGVAKWVDLLAPVVEDGLDDDRVDPDADASLVDQLVEYNVDRQVAFLQENEDVPDSVDVYGFVYDFQRVYGDAPGRAYLVNANGETDRQVLQSQVDEQYADHVQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ25</accession>
    <name>R4VZ25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prephenate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446395.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07780"/>
    <dbReference type="EnsemblBacteria" id="AGN01501">
        <property type="protein sequence ID" value="AGN01501"/>
        <property type="gene ID" value="L593_07780"/>
    </dbReference>
    <dbReference type="GeneID" id="16182219"/>
    <dbReference type="KEGG" id="sali:L593_07780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1594"/>
    <dbReference type="eggNOG" id="arCOG00255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_2_2"/>
    <dbReference type="OrthoDB" id="47176at2157"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="28799" checksum="BF79A36EB4191ADF" modified="2013-07-24" version="1">MTAVTLGPEGTYSHRAAQAVDDSVAFRESVTAIVEAVASGEFERGVIAIENSIEGSVTESLDALAENEVAVVKEIVTPIRHAILAQSEEFSKIVSHSQALAQCRGYLSEHYPDVTREAVASTARGVEHARENPDLAAIGHPANAGDGLQVIAEDIQDSSSNSTRFFVLAHPEDATEAGGKSSFVVYPNTDYPGLLLELLEPFADRDINLTRVESRPSGERLGDYVFHVDVNAGLYEERTQAALDDIREIASNGWVRELGSYDVETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZP2</accession>
    <name>R4VZP2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447609.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13880"/>
    <dbReference type="EnsemblBacteria" id="AGN02715">
        <property type="protein sequence ID" value="AGN02715"/>
        <property type="gene ID" value="L593_13880"/>
    </dbReference>
    <dbReference type="GeneID" id="16180848"/>
    <dbReference type="KEGG" id="sali:L593_13880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2840"/>
    <dbReference type="eggNOG" id="arCOG03104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069299_0_0_2"/>
    <dbReference type="OrthoDB" id="47104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043901">
        <property type="entry name" value="DUF5787"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19100">
        <property type="entry name" value="DUF5787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="36183" checksum="7DD9F0ECC5C83991" modified="2013-07-24" version="1">MREFGFELSLCARLEARGVPTLDGKDAIVARQLGAGVANPGGRVLDAVLVEPGPAFDDRAAITPERIPASVIDADLGPGRSRRVTDAFDVRPDRARSIAEHAAEIGVLELDRRSGHLHARQVARYPDRWFDRLVGIENKPDLGTPGALEEQLRIDVSLGVADRIVLATESYVTGAHRNRIPDDVGIWRFDPEADELVVIREAALLPAGEPGVEVLERQAGRAEIEVVDPDAKARARRRIAERAYGKGWRTFSFPECEQGTTRNRHGASLPWCAWKDRVVDPASECGPDCPGFEPADAPVVDGQTERMRASPWVAEPEGRKRRQTGLDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZT2</accession>
    <name>R4VZT2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">radB</name>
        <name evidence="3" type="ORF">L593_08880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446615.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08880"/>
    <dbReference type="EnsemblBacteria" id="AGN01721">
        <property type="protein sequence ID" value="AGN01721"/>
        <property type="gene ID" value="L593_08880"/>
    </dbReference>
    <dbReference type="GeneID" id="16182566"/>
    <dbReference type="KEGG" id="sali:L593_08880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1821"/>
    <dbReference type="eggNOG" id="arCOG00417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_2_0_2"/>
    <dbReference type="OrthoDB" id="93716at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00350">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02237">
        <property type="entry name" value="recomb_radB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="27023" checksum="A725389353DDE25A" modified="2013-07-24" version="1">MSDPIPTGCEPLDELLGGGFERGTVTQLYGPPAAGKTNVVLSAAAAVAADGGTTVIVDTEGVSIDRFEQVVGARARPETAPDGPAVDDAVAAADAGAGEDLQTLAERIVVQDALDFAEQREAVKDAEAFAEQADLIALDSATGFYRLQRDKDQEGGEALRAVADQITHLLSLARREDLAVVITNQVYTDPEEDRIHALGGHTLDHWTGTILRIDRFRGGNRRATLEKHRAKPAGETAQFRITDEGLAGTEQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZZ2</accession>
    <name>R4VZZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02825">
        <property type="protein sequence ID" value="AGN02825"/>
        <property type="gene ID" value="L593_14430"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14430"/>
    <dbReference type="eggNOG" id="arCOG07539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206273_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6527" checksum="F7BFFDFB56920A3E" modified="2013-07-24" version="1">MNKLWQLDSDTIGVTIPKVDLRLDGLLDDAGDLEGEHHVHIDRQDSSEWELTLEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W037</accession>
    <name>R4W037_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14705"/>
    <dbReference type="EnsemblBacteria" id="AGN02875">
        <property type="protein sequence ID" value="AGN02875"/>
        <property type="gene ID" value="L593_14705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3002"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="39315" checksum="FD4714DB6378DEE3" modified="2013-07-24" version="1">MADVLLVVGATLAVALVFGEVLERLGEPALVGEIVAGLVLGPSVVGLIDYDGTFAVFATIGAMLLFFDVGYEHLDLTELLAVGPAAISIGLCGMVVPAATGVALGLAFGYGAVETAFLALALSVTSIAVTARTLVDLERLESRIGHRIVGAAVVDDVLGLLAFALLLTTVSGEGFQAAVTTLGKVIVFFAAVAVARFGIVAWLSSLLARSRQIGVDVLALLSAVFLGSYGAEAAGLDVTIGALVVGLLVGENERFSRLEVREGIVGIGYGVFIPIFFAGVGARIDLRVLSTLDAFLIAVVTLGVVSKFVGGLVGNAIAGGDVGESVAIGVGMVPKAGVGLAIVGTALTEGYVTRQLFSAFVLLVLVSVLVTPSLLQIAIRRMTAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0A3</accession>
    <name>R4W0A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446810.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09855"/>
    <dbReference type="EnsemblBacteria" id="AGN01916">
        <property type="protein sequence ID" value="AGN01916"/>
        <property type="gene ID" value="L593_09855"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2029"/>
    <dbReference type="eggNOG" id="arCOG02845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264540_0_0_2"/>
    <dbReference type="OrthoDB" id="60810at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="25832" checksum="08B24A63826B4C71" modified="2013-07-24" version="1">MPSPYDVLGIDRDADEETIRSAYRERVLESHPDHGGSPAAFDRVRTAYEELLGEGRTPAPEPEAVGPDQRSPWSPTVSWDDEDEADADPEPAPEPEPHTVEYVDYEVLSDHGWSITDDDLFEKASEADLDPGDYGRFQIDRGDTLLEGAEDVGFTWPFSCRGGACANCAVAVVEGSLAQPVSHILPDELTDEGIRLSCVGTPVTDDLKVVYNVKHLPEVEDLLLPPGPYKRVASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W184</accession>
    <name>R4W184_9EURY</name>
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            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11940"/>
    <dbReference type="EnsemblBacteria" id="AGN02331">
        <property type="protein sequence ID" value="AGN02331"/>
        <property type="gene ID" value="L593_11940"/>
    </dbReference>
    <dbReference type="GeneID" id="16180476"/>
    <dbReference type="KEGG" id="sali:L593_11940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2457"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OrthoDB" id="105856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="26606" checksum="078AE4EAA7811BC8" modified="2013-07-24" version="1">MVEAFAVASGKGGTGKTTSVLALGMALAEEYDVTVVDADTGMANLLFHAGLADVDTTLHDLLVEDPELPVEDAVYERHGLSVVPCGTSLAGFSAAHPERLRDVVAELADDTDVILLDSPAALGSKSAVLPIVLADRTITVLQPTVPALSDGLKVREYARSYGTEGAGVLFNRVTDDRAVERVSASSDRYFDGPVLGVVPESEAVRAAREAGKPLLAHAPDSSAASAYREAARTLTVEAGDPGAVADRFASAVVPDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1B8</accession>
    <name>R4W1B8_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_12190</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02381">
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        <property type="gene ID" value="L593_12190"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12190"/>
    <dbReference type="HOGENOM" id="CLU_2299462_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11778" checksum="D28804D9882C41C0" modified="2013-07-24" version="1">MQANQDRLADIIAENEMTLRTFWNRLNHPNRDIQKYTGPDDVKDVLQNKHGSDYWKRLYFGWEVDTDQNANTIVEDTVEKLTDLDRLFHDPADGLDEMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1H0</accession>
    <name>R4W1H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447350.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12585"/>
    <dbReference type="EnsemblBacteria" id="AGN02456">
        <property type="protein sequence ID" value="AGN02456"/>
        <property type="gene ID" value="L593_12585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180089"/>
    <dbReference type="KEGG" id="sali:L593_12585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2583"/>
    <dbReference type="eggNOG" id="arCOG04642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507350_0_0_2"/>
    <dbReference type="OrthoDB" id="86465at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043827">
        <property type="entry name" value="DUF5804"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19120">
        <property type="entry name" value="DUF5804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="17628" checksum="31C0425373906ECF" modified="2013-07-24" version="1">MTRVCLLGDEEHDLRFELLSRDTSREALSTYDLDQPFANAVGLETVSLGAAVSLLNDLNWYVVRFAEDAFVLDSSVSETEWLSRSLAEAVRSDRVRPEETAEYCTIYGIERDAPSAPGELVEPLYARRTDDGLPEYDLRDVEETVVVRVTESEFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1S8</accession>
    <name>R4W1S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447495.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13310"/>
    <dbReference type="EnsemblBacteria" id="AGN02601">
        <property type="protein sequence ID" value="AGN02601"/>
        <property type="gene ID" value="L593_13310"/>
    </dbReference>
    <dbReference type="GeneID" id="16180522"/>
    <dbReference type="KEGG" id="sali:L593_13310"/>
    <dbReference type="eggNOG" id="arCOG06389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157003_0_0_2"/>
    <dbReference type="OrthoDB" id="105248at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="12176" checksum="FDFFB48639D884D3" modified="2013-07-24" version="1">MAVRDSRAEVRGTVSLPAVVPFSLPHLTRTSYELGTRSIEDEEATLLERWRHRSDRWALSVFAVTNETVLLRVRTPVGRARFYGAIRSELDSAFRSLAASSDWRQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W257</accession>
    <name>R4W257_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13910"/>
    <dbReference type="EnsemblBacteria" id="AGN02721">
        <property type="protein sequence ID" value="AGN02721"/>
        <property type="gene ID" value="L593_13910"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2846"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_5_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="18006" checksum="8BC4C66BE2A40AF7" modified="2013-07-24" version="1">MDRIEVSTGTGWEDHVGYSRAVRVGNQIHVAGTTAVDENGEPVAPGQPYEQANHAFALVEAAIRDAGGEPSDVVSTRMYVTDVEDWEDVGRAHGEAFGDARPAATMVEVSALIDPDLVVEVEATAILETDGENGTDGESGSDAESDSDGESDSDGESDSDGESSSAAESSSDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2M2</accession>
    <name>R4W2M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome C oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_00385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00385"/>
    <dbReference type="EnsemblBacteria" id="AGN00032">
        <property type="protein sequence ID" value="AGN00032"/>
        <property type="gene ID" value="L593_00385"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.78"/>
    <dbReference type="eggNOG" id="arCOG04650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_5_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="543"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="797" mass="88712" checksum="3445FABCFEE663E7" modified="2013-07-24" version="1">MFSTNHKDVGIMYLLTSLYVFAVGGIMALLIRTQLWTPGASILESIPYNEVVASHGLLMIFWFITPFAAGLANYLVPLQIGADDLAFPRLNALSFWLYFVSLLVYLTSFFFEGTYAAGWTMYAPLNLPMYTPTIGGSITVFALAMLMFSSTIASVNFITTIHYCRAEGLGLWNVPLFTWSWLLTVWMMLFAFATLLAALLMLGSDRVLGTLFFAGERGGGSLLWGHLFWFFGHPEVYIVFFPPLGILLEVFQTYSGRRLVGRKWVILAMVLVALQSFLVWMHHMFLTTINLEIKTLFMATTIGISLPFDLIVFSLIYTIVKGKIRFKTPFLFALGGLLLFVPGGITGVFLGAVVLDYEFRGTYWVVAHFHYVMLGGGGTALIAGLYYWFPKMTGRMYDELLGKFHFVLYFVGFNLAFGAQFVAWETPRRVFAYFPENTTWHQISTIGAFLLGVSFIVMFYNLGKSAFRGPSADERPWEFVRTGEWATSSPPPLENWPGRPTYRNGVLEFVETHESVTRPGDSATRADGAGTAQPEPALESGEEGGELHPDHASPWPIVVAFGVGLLFLGFGLAQRGGVLAVSTGTAGLLVLLVGTLQFGREDFYAPVSPIAQRWPFEDVGRGKLGMWVFLASDVMVFGSVIGSFIFARIRLGWDSWKTIPPSVVPGLVNTYILLTSSFLVVLAFEYARRGERGRLVGSLAGTLALGVVFLGIKAYEWTEEFAHGVYWDSSIEASAYFFTTGLHALHVILGLAVASFMIVRANDGVYDGNEEPVELFGLYWHFVDIVWVFLFPLFYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2R5</accession>
    <name>R4W2R5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ORF">L593_00735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444996.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00735"/>
    <dbReference type="EnsemblBacteria" id="AGN00102">
        <property type="protein sequence ID" value="AGN00102"/>
        <property type="gene ID" value="L593_00735"/>
    </dbReference>
    <dbReference type="GeneID" id="16182265"/>
    <dbReference type="KEGG" id="sali:L593_00735"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153624_0_0_2"/>
    <dbReference type="OrthoDB" id="108021at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11761" checksum="320503CB564F938A" modified="2013-07-24" version="1">MTFVTTLELESGDRRALDSVVADIKETVERKGAEFKGPHTPPPETLAVPLYDDLERGGHFDSWSYTVYTRTVEIVGHDELASSIATRSFPDQVHVEADVRSIQQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V4</accession>
    <name>R4W2V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445066.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01095"/>
    <dbReference type="EnsemblBacteria" id="AGN00172">
        <property type="protein sequence ID" value="AGN00172"/>
        <property type="gene ID" value="L593_01095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182313"/>
    <dbReference type="KEGG" id="sali:L593_01095"/>
    <dbReference type="HOGENOM" id="CLU_1634695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="18298" checksum="1D0AE9923105DA7D" modified="2013-07-24" version="1">MLAALLAILVFLLVVEPLLVGLHELGHAIVPLALGNETAVFVGGKRGLSGSVGSLTLTVAPAGLRSPITEGAVVTDVQTGRWAVFAGTLGGPISSLLLAVTAAFALEFVRGPFLQWLVLFAFAYSTLQALSTLAPFRGPVPTDGGEPFKTDGRIALELLLGRDPVLDGDGGPLSSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Z2</accession>
    <name>R4W2Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445106.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01295"/>
    <dbReference type="EnsemblBacteria" id="AGN00212">
        <property type="protein sequence ID" value="AGN00212"/>
        <property type="gene ID" value="L593_01295"/>
    </dbReference>
    <dbReference type="GeneID" id="16182815"/>
    <dbReference type="KEGG" id="sali:L593_01295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.264"/>
    <dbReference type="eggNOG" id="arCOG03019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061176_0_1_2"/>
    <dbReference type="OrthoDB" id="45544at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="35784" checksum="2571B2CAEB564EB2" modified="2013-07-24" version="1">MDSALVVGGTRFIGRHLVDELLEHDYEVTIFNRGNHDNPFANHDDVGHVKGDRKSDAALEHARDEVDPDLVVDCVAYYPGEVRIATEIFADVDAYVFVSSGSAYGPDEIPKREGQTDLEPCTEEQAVDDSHETYGARKAEGDRAVFEAAADGVRAMSVRPTIVYGSHDYTGRLNYWTERVREQDRVLVPGDGTNIHHLVAVENVARAIRTVAEQGEAGEAYNVGDHRVLTLGEVVETIAAGLDADVELVTASERELVADDLEPTDFPLYNPNPHVLSTTKLYDLGWDPVDPADAIAETVTTEYEIERDPGPDPAETDTVLDRLDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W304</accession>
    <name>R4W304_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">L593_01395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445126.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01395"/>
    <dbReference type="EnsemblBacteria" id="AGN00232">
        <property type="protein sequence ID" value="AGN00232"/>
        <property type="gene ID" value="L593_01395"/>
    </dbReference>
    <dbReference type="GeneID" id="16181705"/>
    <dbReference type="KEGG" id="sali:L593_01395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.284"/>
    <dbReference type="eggNOG" id="arCOG04131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OrthoDB" id="99734at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="30303" checksum="D6B6F8EEB702B4DE" modified="2013-07-24" version="1">MRDPDGLLARAGVSGNPDRDQHFLVDDRVLDRLPDHLDPAAADSGQIEHVLEIGAGTGALTDRLLERFDRVTAIERDPTLATFLREEFADAIEAGRLDLIEGDALAVEYPDFDASISNLPYGASSEFLFRLLPTGKPLVLTVQLEFAERLAAEPGTPEYGRLTVSAGHYADVDLVEPVPPEAFSPPPAVESAIVRATPRTPTYDVADDEFFLRFVKAVFTQRRKTMRNAIRNTAHISDLDDPDAVVAAADEDLMSARAGELPPERFAELASLALAEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3H9</accession>
    <name>R4W3H9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truD</name>
        <name evidence="7" type="ORF">L593_02955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445436.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02955"/>
    <dbReference type="EnsemblBacteria" id="AGN00542">
        <property type="protein sequence ID" value="AGN00542"/>
        <property type="gene ID" value="L593_02955"/>
    </dbReference>
    <dbReference type="GeneID" id="16180224"/>
    <dbReference type="KEGG" id="sali:L593_02955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.598"/>
    <dbReference type="eggNOG" id="arCOG04252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_2"/>
    <dbReference type="OrthoDB" id="92795at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="6">
        <location>
            <begin position="217"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="495" mass="53272" checksum="D6BB390C75E991F7" modified="2013-07-24" version="1">MADSSDDGATRRFDLRPAHPTEQAVGIEHYVTDVDGTGGRLRRSPDDFRVREIERIDPEPIDADPGAYGHVVVRATLRSWDTNDFAGTLSDRLGISRHRVHWAGTKDKRAVTTQLFSIDGVDPAVIPGAGAASSVDGAADATGQKATPAIDEADVEVLGRLGRSIELGDLVGNEFEVRITDAERPEHVGPITDALATFRTGGDAPDRDEPGNPTPVAVPNFFGQQRFGSRRPITHAVGLAIVRGEWREAVRIYVADAYDSEPDSTQDARAAAGDCFDDGDWTGALDAMPNRLGYERTLLHALERADADPGDDAAVFREALADLPENLQRMFVHAAQSYAFNRILSARLDAGLPFHEPVAGDVVCFADAGAPEEVALPDTDRLQAVTADRVDTIARHCERGRAFVTAPLVGTDTDLGDGDPGEIERRILDDLDLSPGDFDLPDPFGSTGTRRAVLVGTELSIDDHDEPTLSFALPKGSYATVLLREYLKVDPIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3L7</accession>
    <name>R4W3L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03280"/>
    <dbReference type="EnsemblBacteria" id="AGN00607">
        <property type="protein sequence ID" value="AGN00607"/>
        <property type="gene ID" value="L593_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03280"/>
    <dbReference type="eggNOG" id="arCOG04593">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139548_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="12972" checksum="5212FCD0BF731A46" modified="2013-07-24" version="1">MTDDRTDDERRSTDAASNDPFEPPEPGSDAPAKRAGRPEVVVPMDLYKTITVFSTLFAIALVVGGMIALDAATGRASRAVEDVNLPIAFLGVAAIVLGAATYAFAARFRAEGMGNPKDGDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3S9</accession>
    <name>R4W3S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445601.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03780"/>
    <dbReference type="EnsemblBacteria" id="AGN00707">
        <property type="protein sequence ID" value="AGN00707"/>
        <property type="gene ID" value="L593_03780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181338"/>
    <dbReference type="KEGG" id="sali:L593_03780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.767"/>
    <dbReference type="eggNOG" id="arCOG00020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_3_2"/>
    <dbReference type="OrthoDB" id="64383at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="275" mass="28078" checksum="93EE86875A55F6D2" modified="2013-07-24" version="1">MQAPSPTEPPVALSIAGSDSGGGAGIQADLQTMAAHGVYGTTAITAVTAQNTRGVEDSHVLPVEVVEAQYDAVLSDFDVKAIKTGMLATTPIVEAVADRVADAGLPAVVDPVMVATSGDRLLTEDAEAAYEDLIAEATLVTPNADEASVLTGTEVTGRESAERAGDALLEMGADAALIKGGHVAGDPIRDVLVTPERTQVFEHGRVDTEATHGSGCALSSAIAALLARGEPLDAAVGEGTDFLERAVRHHYDVGQGPGAVNHLVDLRVRTDGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3W5</accession>
    <name>R4W3W5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445656.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04055"/>
    <dbReference type="EnsemblBacteria" id="AGN00762">
        <property type="protein sequence ID" value="AGN00762"/>
        <property type="gene ID" value="L593_04055"/>
    </dbReference>
    <dbReference type="GeneID" id="16180731"/>
    <dbReference type="KEGG" id="sali:L593_04055"/>
    <dbReference type="eggNOG" id="arCOG10664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_1_1_2"/>
    <dbReference type="OrthoDB" id="23118at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="45666" checksum="360DDB3F4191BBAD" modified="2013-07-24" version="1">MADYRPVTDDRRARYHAIMQQAFDAESGPAPSYADGDADEDPEDWPPDLSDPRGLVADDEVVSTCKLYYLDATVRGEWTEIGGLGGVATPPEHRRKGYSRETLQGALTEYREQGVDLVALWPSTVRFYRGLGWGVANRTQRARVPPAQLVEIEGPEPAGGDDGRFRQLDADDWERLRSVEVERAQRFGLSLRRTEEWWRTRTLAAWPSGPGPYVYGDEVDGDLRGYVLTHVREGEDGKELKVQDLAGVDHAAERTLLGFLANYDSQVETVVLDGPLAGDLPELVPDPGELDVTESVGTMIRLTDVQRWLEGYEWPASVEDRFVLDVADPLLDRNADQFLVHVADGEATVESAGGDLAGDATLGIGTLSRLAIGAIDVDRAERLRDLQVHDDASRETLETAFPAEPVYLREFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Y4</accession>
    <name>R4W3Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_04230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445691.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04230"/>
    <dbReference type="EnsemblBacteria" id="AGN00797">
        <property type="protein sequence ID" value="AGN00797"/>
        <property type="gene ID" value="L593_04230"/>
    </dbReference>
    <dbReference type="GeneID" id="16180833"/>
    <dbReference type="KEGG" id="sali:L593_04230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.860"/>
    <dbReference type="eggNOG" id="arCOG02387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="597"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="806" mass="88529" checksum="B7E238D4068ED4A1" modified="2013-07-24" version="1">MTTQTQSVRILHVDDEPGFADLVATYLGREDDRITVETATAASDALDLLAERQFDCVLSDYDMPGRNGIEFLEAIRERHGDLPFILYTGKGSEEIASEAIAAGVTDYIQKDSGSDHYEVLRNRCLNAIEAHSARRRAENLDRIRSVARDVNQALLRAETRKEAEEAVCQVIAEAEPYQFAWIGQEDPETETVVPRASAGADEGYLSSVEITTDDSETARGPTGRAIATGSLQVVQSVRESSTYDPWRGDALDREFRSSAAVPLLHESASFGVLNVYADRTRPFDADERELLEELGSDVAHALHTLQIQADLRETSTRLEALFEHSPDMVDIHGIDGTILDANPRLCDSLGYSKEELCGMDVWEIDETIDPAAATQIWEEMDAGDRCELEGSYRRRDGTTFPVEVHLERLDIEGEGPLFMVISRDVTERKRSEDVLTALHEAGSRITACDTVGAVCEETVRVAASILEFDESMIALEEDGVLEIRATSEHMRDDAVRPIPVDEGVAGKTYRTGEPVLTEDMRDEPDADPQGDFRSGISLPIGDHGNFQAVADEPGAFDETDIELAELLLSQVDSALTRLRHEEQLRERNERLDEFASLVSHDLRNPLTVATGHLELAREDCESEALETVETALSRMDDLIEELLTVARGDVDKLSTRPVSLPSVLEECTEVVDTNDATIESRTERTILADHQQLRQLLENLLANAVEHGSTSPGSQAPQDAVESDNDGVTITVGDLEDGFFVEDDGPGIPPERRDDVFELGNSTDDDGTGIGLHIVAQVAENHGWSVSVTEGSRGGARFEITGVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W449</accession>
    <name>R4W449_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445806.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00912">
        <property type="protein sequence ID" value="AGN00912"/>
        <property type="gene ID" value="L593_04815"/>
    </dbReference>
    <dbReference type="GeneID" id="16181103"/>
    <dbReference type="KEGG" id="sali:L593_04815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.984"/>
    <dbReference type="eggNOG" id="arCOG04534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2461697_0_0_2"/>
    <dbReference type="OrthoDB" id="116142at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="9701" checksum="AC260BF6ECF56454" modified="2013-07-24" version="1">MQPCHNCQTVIDEYLLDKQLEPLRELTVDDFNVCADCATIVADACVTCGGAVYVPRSESDTPDYCPACRADHIDCTGQDPGWSRSQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W478</accession>
    <name>R4W478_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05065"/>
    <dbReference type="EnsemblBacteria" id="AGN00962">
        <property type="protein sequence ID" value="AGN00962"/>
        <property type="gene ID" value="L593_05065"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05065"/>
    <dbReference type="eggNOG" id="arCOG00551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047666_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="33136" checksum="08C0C13AE8E8BE92" modified="2013-07-24" version="1">MPVLAAAERPARAEVSTVNLDELRAVQDREREKDSLQHLRDSFYSEVGQYIGDLRAERERQADRAEDPFADAEVRQLTDEIETAEEVAESIYERRMGKVVKTASLAAAGYRAETEGLTAEESELFDDLVDRIEANQSTVLDVLAGDDAVEPPGDAEAALDAADGGANGADAPPAPPSPPSGDGSDGATAADGADGDGTADGDDGDRPAAEALAATAPDDGNGGAGSASSGGSASSSGGSAGSSGGSAVSSGGSAAAEGAGDASGDGDGALTTDAAAAMGDPDRVTVRITAEVGEIVGIDGTAYDLHADDVVTLPEENAMPLVEKDAATKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4D7</accession>
    <name>R4W4D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05590"/>
    <dbReference type="EnsemblBacteria" id="AGN01067">
        <property type="protein sequence ID" value="AGN01067"/>
        <property type="gene ID" value="L593_05590"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05590"/>
    <dbReference type="eggNOG" id="arCOG01881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089196_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="22605" checksum="E3B9B023E4420561" modified="2013-07-24" version="1">MPDQRTEGQVGEDGRIGSGLAAVRERLEGELGRRLVHVSGAGIPLLYVLGLPYAWLQILLVGGVAIVGGLELLRLRAGLADWWIFEHLTREYESETIAGYALYVVGMAVVAVAFDPQIAIPSMFMLAVADPVGGVLGGADPTPVKPARAFVGAFVVCLLVGLPFLPPLVAAAGGVAASVADGVFAEFRGYVIDDNLTIPIGAAAAIALMLAYGPGWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4J9</accession>
    <name>R4W4J9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06140"/>
    <dbReference type="EnsemblBacteria" id="AGN01177">
        <property type="protein sequence ID" value="AGN01177"/>
        <property type="gene ID" value="L593_06140"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06140"/>
    <dbReference type="eggNOG" id="arCOG04818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217157_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11900" checksum="E1AB946CBDF97E32" modified="2013-07-24" version="1">MNDQTSSRELLLSKAVAELTDTDITFLINGNEDHNDYIKSRVERNAEVVDVPDLHAKAVITDDWVYAGSANITRRGLLVNRELCKIVTNTHPDANTYVEEELSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4M7</accession>
    <name>R4W4M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01202">
        <property type="protein sequence ID" value="AGN01202"/>
        <property type="gene ID" value="L593_06265"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06265"/>
    <dbReference type="HOGENOM" id="CLU_2476164_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="87" mass="9602" checksum="D736C1918622F5DF" modified="2013-07-24" version="1">MLLYLLLLLNSDSVDQSSEIFARTFYTFMMAFFPTNEVALILDVIMGTLGASVAASELRAKTVGILIAFGFCWSATNILINWFTAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P4</accession>
    <name>R4W4P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446136.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06475"/>
    <dbReference type="EnsemblBacteria" id="AGN01242">
        <property type="protein sequence ID" value="AGN01242"/>
        <property type="gene ID" value="L593_06475"/>
    </dbReference>
    <dbReference type="GeneID" id="16181777"/>
    <dbReference type="KEGG" id="sali:L593_06475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1320"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_0_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="138"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="42033" checksum="E706869D661001DE" modified="2013-07-24" version="1">MYDVGFLGYKFMGKAHGNALARLPMFFPEAPETNRHVLIGRDEEALADAADRFGFETTSTDWEAALDEIDVLYNLGPNWLHVEPTIEALDRGIHVFSEKPLAPTAEDAARVAQAAEASDAMAGVAFNFRAVPALIYAKQLIDDGVLGEIHHVRAQYLQDWLVDPDAPWSWRNDEEMAGSGALGDLGAHTVDAIQWLVDDVARVSGQLKTFVDERPVEGQDARGDSVGHEEGAETETKPVTVDDAYTANVELENGAIGTIEASRFANGRKNDHTIEIEGSKGSLRYDHERLNELEVLREDDRGYETILVTDADDPYVDRWWPPGHIIGWEHTFVHENYEFLTALEAGEQFQPDFQSGLQVQQVLGAIEESDETGAWVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4R4</accession>
    <name>R4W4R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446181.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06700"/>
    <dbReference type="EnsemblBacteria" id="AGN01287">
        <property type="protein sequence ID" value="AGN01287"/>
        <property type="gene ID" value="L593_06700"/>
    </dbReference>
    <dbReference type="GeneID" id="16181846"/>
    <dbReference type="KEGG" id="sali:L593_06700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1368"/>
    <dbReference type="eggNOG" id="arCOG00924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="55756at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25508" checksum="D4EF8C5F5C6D1BF3" modified="2013-07-24" version="1">MTAIELDDVHTYYGQSHILQGVSLSVEDGENVALLGRNGVGKTTTLRSILQLTPPRSGTVRVHDEDVTGLPTHEVARRGVGWVPEERRMFSHLTVAENVRASIPPEADPAERMRRAFDRFPDLEELREHEAGSLSGGQQQMLAIARALVGDNDVLLVDEPSEGLAPLIVEEVVEALEDLPDDQTLVLVEQNVPMALALTDRFYVLDHGEVVAEGDSADASLEDDRIRRYLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4U2</accession>
    <name>R4W4U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446226.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01332">
        <property type="protein sequence ID" value="AGN01332"/>
        <property type="gene ID" value="L593_06925"/>
    </dbReference>
    <dbReference type="GeneID" id="16181927"/>
    <dbReference type="KEGG" id="sali:L593_06925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1415"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_2"/>
    <dbReference type="OrthoDB" id="38489at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="370" mass="40156" checksum="CB46464F6EC08ADE" modified="2013-07-24" version="1">MKVTDVEAIPVAMEVLPESDPNGLAPYVTNHGQVETMERMLIRLETDSGVTGWGEMRSSLALETTASVIENDVAPELVGRSVAEAEAFADEFFYEYLDVGPFVGGVEMAMHDALGKIRGVPVHELLGGKTRDSVEFAYCVGILDEEDSREHARRALDGGYSVLKTKAGRDWTEDVRRILAMDDEADGELSFRLDPNQGWTPDQAVRVGAALGDNGVYCQYLEQPVRIDSVGTYESLRNRLRTPIAVNEDTYFDRNLFQHGAAGAIDCAVIDVVPAGGFRAAKRLAGVADDAGISLAHHNAFDLGVKTAAVLHLTASTPAINLPPDTIYYAWADDVIAEPFEVDDAEIEVPDGPGLGVDVDEGKLEQYRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4V7</accession>
    <name>R4W4V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446251.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07050"/>
    <dbReference type="EnsemblBacteria" id="AGN01357">
        <property type="protein sequence ID" value="AGN01357"/>
        <property type="gene ID" value="L593_07050"/>
    </dbReference>
    <dbReference type="GeneID" id="16181989"/>
    <dbReference type="KEGG" id="sali:L593_07050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1441"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541455_0_0_2"/>
    <dbReference type="OrthoDB" id="41033at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="333"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="489" mass="52565" checksum="006A5B0E74D81B71" modified="2013-07-24" version="1">MADDGAIFKGYLSVFAGDLGRLLIFAAFIPLLVRTVGESGFGRYALVMAIFLPSRKILNLGLFEATKTYASREEGEDRSRVIATSFALHAGMLLVGIPLLAAAFFLFTDGPLQQALYLMLGAVVGEQLYYFGRGVLHAYKREAIVEPLIPVRSIVMAVVGLTLAAEGYGVPGVFAGFATGFLLTGVLSTLLAFREAGFVPSPKRLAFSIYGRPLLRFGVQTMALVLLLTSMFKVDILLVSYFEDAATTGHYRAALQVSEFMWVVSVAMEQVMIQSTAVMWEEDATGELTALLSRMLRYVVVITVLLVAGVFVLSEQFLTLYFGPAYEASVLPLRVLLPGVLGFAIARVIWPVLQAGGHLRTLLLATGTAVVLNVVLNLVLIPEFGIVGAAIATSIAYGSMAVTHVLAARTVDIQPTDGLPILRVAVLGLATIGILWVLVPLGPWWVDLFVLPWIGLAFYAVGSQVLDVLTVGELRGLVAEFTPSEPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4W6</accession>
    <name>R4W4W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="6">IMP dehydrogenase</shortName>
            <shortName evidence="6">IMPD</shortName>
            <shortName evidence="6">IMPDH</shortName>
            <ecNumber evidence="6 13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">guaB</name>
        <name evidence="16" type="ORF">L593_07125</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
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        <text evidence="6 13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
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    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
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        <text evidence="1 6 12">Belongs to the IMPDH/GMPR family.</text>
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        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <sequence length="502" mass="53862" checksum="03C3CBE558B5F25B" modified="2013-07-24" version="1">MANDVPHEEPFTEKLRVPEALTFDDVLLRPKESTVEPDEADLSTRVSTNVELNVPVLSAAMDTVTEADLATALARQGGLGVLHRNMDVDDTVEHVEAVKTADELVIDRENVVTARADQTVRSVDDMMDEQGVSGAPVVDEDDQVLGIISATDLRPYLEVGERDEVSEAMTDEVITAGEDVGAREALELMYEHKIERVPIVDEENRLTGLITMQGILQRREHTNAVRDGEGRLRVGVAVGPFEEERATRADDAGADVLFIDTAHAHNRNVIEGSRDIASRVDADVVVGNVGTREAARELVDFADGIKVGIGPGSICTTRIVSGSGMPQITAVAQVADVASQHDVPVIADGGIRYSGDAIKAIAAGADAIMMGSYFAGTDEAPGRIITMNGKRYKQYRGMGSVGAMSADETDDNRYLKEEPDDGDEYVPEGVEAATPYKGSLESELHQLTGGMQSGMGYVGAESIPEFKQRSEFVRVSSAGQAESHAHDVVITDEAPNYSPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Y8</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="AGN01412.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="284" mass="29761" checksum="36511918D68961B2" modified="2013-07-24" version="1">MAGDFDAETDREGVGGGDPRLSAEYVRTIEADSAGNEDGSGRGTVTLVGVVHDHPASAFRARTVVQRQAPDVLALELPPLAVPLFEHYAAGSDAEPGDASAEDGQEPDDEAWEGDRWTPPERGGEMSAAIRAAKADRVAGIDGPTPGFAVVLARHLLAEDSSFSTARAAVARFARASGHAIRCRLAAARATLTEQIPVPSAPREHAVTPGDPPATQAEDERRQVRLARSIAAAFGEERSVAVRDEPRESHMAARLASFAADGDDVVAVLGIDHLAGVATLLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5L3</accession>
    <name>R4W5L3_9EURY</name>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="HalOD1"/>
    </dbReference>
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        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8976" checksum="34796EFCCEE7713C" modified="2013-07-24" version="1">MAETDIVARVVDAVAAADGVEVTDVDPVYEYMYPEVLQKLCEHEGGEWSLTFQFADHQITVTHESRIFVDGVAYTHDASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W610</accession>
    <name>R4W610_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446941.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10510"/>
    <dbReference type="EnsemblBacteria" id="AGN02047">
        <property type="protein sequence ID" value="AGN02047"/>
        <property type="gene ID" value="L593_10510"/>
    </dbReference>
    <dbReference type="GeneID" id="16182551"/>
    <dbReference type="KEGG" id="sali:L593_10510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2166"/>
    <dbReference type="eggNOG" id="arCOG08941">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_0_2"/>
    <dbReference type="OrthoDB" id="40182at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="35255" checksum="CD2656BD26F42C60" modified="2013-07-24" version="1">MKKLINDPADVVDEMLDGMVAAYPDSLRRLEGNEVLVRADAPVDGKVGVVSGGGSGHEPTHAGYLGEGMLDGAAAGEIFTSPTADQLEAMIEECDAGEGVLSVVKNYEGDVMNFDTAAEMVEMEDVDVRQVVVDDDVAVEDSLYTSGRRGVCGTILVHKVAGAAAARGDDLDTVVEHAEGVIDNVGTMGTALTSCVTPEKGEPTFDLGEDEIELGIGIHGEPGTERVDMMPADDVADHLTEAVLEDLDLDAGTEVLTIVNGMGGTPLSELFVVERRVDELMDEHDLEVWDAWVGDYMTSLDMEGCSITVCALDEERKELLAAPADTPALTVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W649</accession>
    <name>R4W649_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BioY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447006.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10835"/>
    <dbReference type="EnsemblBacteria" id="AGN02112">
        <property type="protein sequence ID" value="AGN02112"/>
        <property type="gene ID" value="L593_10835"/>
    </dbReference>
    <dbReference type="GeneID" id="16182042"/>
    <dbReference type="KEGG" id="sali:L593_10835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2236"/>
    <dbReference type="eggNOG" id="arCOG02986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_2_0_2"/>
    <dbReference type="OrthoDB" id="92598at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23130" checksum="ACA3CB24D3D50AD6" modified="2013-07-24" version="1">MSSGVTTVARDSLRRSAAAGGYLHRVRTEADLLERLLLVGGFAALTGLAAQVRIPLWFTPVPITLQTFAFLLAGLVLGARFGGLSQGLYVGAGVAGVPWFQAMGAGVGHLAGPTGGYLVGMFCSTLLVGYVVDRYPVREHLSALIGLLAVANALVYVVGLPWLFAWSNLVTGGDVGLWELLVIGLFPFVAGDVVKLLGAVAVGRLLAPPASRYDDAGEPIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B4</accession>
    <name>R4W6B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445167.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01600"/>
    <dbReference type="EnsemblBacteria" id="AGN00273">
        <property type="protein sequence ID" value="AGN00273"/>
        <property type="gene ID" value="L593_01600"/>
    </dbReference>
    <dbReference type="GeneID" id="16179872"/>
    <dbReference type="KEGG" id="sali:L593_01600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.325"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_0_1_2"/>
    <dbReference type="OrthoDB" id="65191at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="30138" checksum="6821681D3798AA4A" modified="2013-07-24" version="1">MSWLAIARKDFRDARRAKILWGATGIFLFFYAVLLLTSSQGGQPADEAAVDAIGGLIFAGAFLLPLVIISMGYLAIAGERESGSIKYLLGLPNSRREVLIGKFVGRSALALTAVGISLVVGAGMLLFQFGTVPVEYLSYSALTCLFAVVFIAIAVGLSALADTRGKAMAGTIGTYVLFSFIWVVPGINPNDSVAFVVEDLLGMDATPELYQFVQNLSPVFAYGNAVDAIVFGPPEGGSSGTNHLDPAAADTPLYLSDQFLVLLLVGWVVVPLAIGYLRFRSAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G2</accession>
    <name>R4W6G2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447186.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11745"/>
    <dbReference type="EnsemblBacteria" id="AGN02292">
        <property type="protein sequence ID" value="AGN02292"/>
        <property type="gene ID" value="L593_11745"/>
    </dbReference>
    <dbReference type="GeneID" id="16181197"/>
    <dbReference type="KEGG" id="sali:L593_11745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2417"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OrthoDB" id="17407at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="308"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="421" mass="47150" checksum="85FB56C151F4BB19" modified="2013-07-24" version="1">MRLDEFLDDFDRDLDAEKRRLAQEKSYAITDHLEDVETRFNDVLSDDTLVGSTSPEIFVGRAGYPNISTGVLSPVGDEDDAEAYATSGQWYDSGLGVSDVLQKRTGLLNSQRRTKVQVDDVWDGFVGAQREVAIADRPVGVEIGLDDRPEIDLTTDDVATPTGPNAKADRVDLTENPYVPRPVKKTLEDDDWQAQGAMNYLWQRGFDVYEINTILSAGALGRSENRRLVPTRWSITAVDDTVGQFMRGQIRNSQSIDEVEVWYNEYVGNRYWVVLAPGQWEYELVEMKGPGSVWNPDESEYFLASASEGYEGRTGYVDETAGAYYAARMGVLEELVERDRQAKALVLREVTDEYWAPVGVWQVREAVRNAFGDGVMDRPATAETFHDAVKGVSSELPVGWNQLRRKSELVAGVQSQLSAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S6</accession>
    <name>R4W6S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447391.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12790"/>
    <dbReference type="EnsemblBacteria" id="AGN02497">
        <property type="protein sequence ID" value="AGN02497"/>
        <property type="gene ID" value="L593_12790"/>
    </dbReference>
    <dbReference type="GeneID" id="16181265"/>
    <dbReference type="KEGG" id="sali:L593_12790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2624"/>
    <dbReference type="eggNOG" id="arCOG00463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_0_0_2"/>
    <dbReference type="OrthoDB" id="119956at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="143" mass="15284" checksum="73908CB64E41F932" modified="2013-07-24" version="1">MTPQGGTYTLLVALDGRRRIEVGALGEITFDHRWYAYTGSALGPGGFSRVDRHREMAAGERDVRHWHVDYLLGHPGTTIDAVWTTPGADRECAIAADLPGDQVAAFGASDCECATHLVGADERATLADAIADVHDLGPANREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S8</accession>
    <name>R4W6S8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445447.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03010"/>
    <dbReference type="EnsemblBacteria" id="AGN00553">
        <property type="protein sequence ID" value="AGN00553"/>
        <property type="gene ID" value="L593_03010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180415"/>
    <dbReference type="KEGG" id="sali:L593_03010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.610"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695609_0_0_2"/>
    <dbReference type="OrthoDB" id="63002at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="38638" checksum="94A0E80A4A0237D7" modified="2013-07-24" version="1">MDPTIVALFLIAALASTFMAWVIGAGSSGATPFAPAVGANAISTMRAAFVVGIFGFVGAITQGANVSETLGSGLVGGVSLPATGVIVALGIGAGLMAVGIKTGYPIATAFTVTGAVVGVGLALGGTPEWATYRQIGAVWLLTPFVGGGIAFTIASVLPRSDVPERLSIPFLAGLVAAVVVNLQFAFVGPGTSAGSIVGAIQRTVGVDGAAPLLAATLAAALAVAALVRWDVARDEAGGLRRVLLSLGSLVAFSAGGSQVGLAVGPLLPLLDEVGAISPIVVLFGGGLGMLVGSWTGAPRMIKSLAQDYSSLGPRRSIAALVPSFLIAQLAVVLGVPVSFNEIVVSAIIGSGAAVGGGAAVDPRKIGMTLAAWAGSFVLAFVVGYVAIVVLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W727</accession>
    <name>R4W727_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT domain-containing protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447556.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13615"/>
    <dbReference type="EnsemblBacteria" id="AGN02662">
        <property type="protein sequence ID" value="AGN02662"/>
        <property type="gene ID" value="L593_13615"/>
    </dbReference>
    <dbReference type="GeneID" id="16180720"/>
    <dbReference type="KEGG" id="sali:L593_13615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2787"/>
    <dbReference type="eggNOG" id="arCOG04653">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661582_0_0_2"/>
    <dbReference type="OrthoDB" id="35841at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="43755" checksum="112744D0E3A8D41F" modified="2013-07-24" version="1">MSDEEPTVESLRERLEAIEAELEAAETEDDLDEVESQIESLEADVEEADLPEPEDEDETPPEEELTDDIESVAGDLEDARGPYAADVVADLEAAVETVESGEWTETGEQQVADAVGSYLDAVSEYVDTPTLHGDDPEAAVEALQSVATDVEEADLDPDDDAETIAGLVEATDALAEDLDDAEEWDDLTVRQQLDAQGYYDVLDHRKDFPPEWGALKVYEKRGEAEPILLALDTFDSDFMEEHCMEALERMGPEEALDEMLARAGKRDKQAIRVLGTIGSEEPVETLLDYVDADVGLQKVTFQALGKIGSEDAVQPLADQLVSDDAEVRSAAARALGLIGDTRAIDPLGDVLADEEESGSVRASAAWALVQIGTEDALDTASEYVDDREYLVQAEAEKAQDATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W738</accession>
    <name>R4W738_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_03785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1333523.L593_03785"/>
    <dbReference type="EnsemblBacteria" id="AGN00708">
        <property type="protein sequence ID" value="AGN00708"/>
        <property type="gene ID" value="L593_03785"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.768"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="22385" checksum="68AD6971D32278E2" modified="2013-07-24" version="1">MEDVEGGTGDGDGCMDGVAVQRCERCPELVDSRSRIVNGVGPEDAALCFVGEAPGAQEDAEGEPFVGRSGDVLDEVLRDVGLSRADVRITNCVRCRPPDNRDPKQGELANCRGYLERELSIVDPEILVTLGKVPAEHLLDRDVAITAEAGDLVETRIGDRPQRLLLSVHPAATLYDRSQREPFEETIERAAELAGEAVGDQSRLGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W752</accession>
    <name>R4W752_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445632.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00738">
        <property type="protein sequence ID" value="AGN00738"/>
        <property type="gene ID" value="L593_03935"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_03935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.800"/>
    <dbReference type="eggNOG" id="arCOG02834">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_042134_1_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
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    </dbReference>
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        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="590" mass="62405" checksum="5805C451E4E685BB" modified="2013-07-24" version="1">MNLVLWIVVGILAYWLLAVTLDRQGVLPEWVHVSGPLLTLHTQRGKDVLDWLARPKRFWRAWANVGLGIALVVMVLSFLFVILSAILTIQNPGSASQVTEPRNVVVIPGFNDFLPLEVAPEILLGLLVGLVVHEGGHGLLCRVEDIEIESMGLALLSIIPMGAFVEPDEESQRKANRGGRSRMFAAGVTNNFLITVLAFALLFGPVIGSIGLAAGAGVGGALSGSPADEAGISGGDRIVAVENQSVETNEELQAVLANESDRRITIETGDGERLSVDRRLIVTGALEDSGVDAGSEVVAVDGTAVSTTPAFREQLRAAGDRATLTVENDTATHDVAITVGARVVVVPDGPLADAGASRNDDLTIVSMGEERIVDQEDIGEAIDGLEPGETVTVVGYVEGDRQTFDVEMGRDDGEAYLGVRGYPGIDGLTVDDLGVRYYPAGNYLAVLGGDGSVDGLPTDSFVGKTFYAVFLPIAGFAGGNALPFNFAGFTDQIQSFYVVEGPLAFLGDGVFLLATALFWIGWININLGFFNCIPAFPLDGGHILRTGAESIVSRLPVEADFALTKVITVSVGLLMGLGLVVMIFGPRYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W761</accession>
    <name>R4W761_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corrinoid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC</name>
        <name evidence="8" type="ORF">L593_04085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445662.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04085"/>
    <dbReference type="EnsemblBacteria" id="AGN00768">
        <property type="protein sequence ID" value="AGN00768"/>
        <property type="gene ID" value="L593_04085"/>
    </dbReference>
    <dbReference type="GeneID" id="16182520"/>
    <dbReference type="KEGG" id="sali:L593_04085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.830"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_2"/>
    <dbReference type="OrthoDB" id="36067at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="37720" checksum="84BB0209EEB7C5F1" modified="2013-07-24" version="1">MHAHRRAATYSSGLLAVLVATVLASAAIGTVHVAPGAVVAAVANQFAIPTAVGVSTTTVGLPFVDAALPVPSLDASYWQPFAFDVAGTDETIVVDLRLPRVLLAATVGVGLAAAGTVMQGLFRNPLADPSIIGVSTGAAVGAVAAITLPALVPLGLQPMAFVTGLLTAFGVYWIATENGRTPVATLLLAGVAIQALLGAVISFLMINSGRSMEEVVYWLMGNLHAAQWSDVEFALPIVVAGTLALWAFSPDMNVLLLGEEDAHHLGIEVERTKRLLLGLATVVTAAGVAVAGVIGFVGLIVPHVLRLLVGPDHRVLLPTSALAGGTFLVAADTLARTTPEVLPVGIVTAAAGGPFFLYLLREREVHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C1</accession>
    <name>R4W7C1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L593_04670</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445777.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04670"/>
    <dbReference type="EnsemblBacteria" id="AGN00883">
        <property type="protein sequence ID" value="AGN00883"/>
        <property type="gene ID" value="L593_04670"/>
    </dbReference>
    <dbReference type="GeneID" id="16181039"/>
    <dbReference type="KEGG" id="sali:L593_04670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.954"/>
    <dbReference type="eggNOG" id="arCOG06232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055277_0_0_2"/>
    <dbReference type="OrthoDB" id="14016at2157"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="15">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="16">
        <location>
            <begin position="170"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGN00883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="47802" checksum="61FA2C49CCE7E581" modified="2013-07-24" version="1">MAGNRIVAIRAIPAVSGFYADDQRAIKRGATQDGFAYDGEPVTEGFKRIREAGEALTVELELADGTYATGDCAAVQYSGAGGRDPFFRAEEYRPVVEGPVADALVGSNPAEFTPLADEIESLPAERSGGDRLHTAVRYGVSQALLDAAAKTRGVTKTDVIADAVGTEPATQPIPVFGQSGDDRRTNAEKMLLKRVGVLPHGLFNSVEKVGAEGERLIEYLEWLAVRTDELGSGASGDENTQSGVPEYRPRFHVDVYGILGEVFGPPYDRREVVEYFHRLADATAPYPLQVEGPMDAGSLSGQIEQMATLRDALAAADVPVDLVADEWCNTLDDVRAFVDAGAADVVQVKTPDLGGVQRSAEAVRYCDGTDVRAYLGGTCNETATSARACAHVALATDAAQVLAKPGMGFDEGYMLVTNEMRRALARREHSDSVARPTPETAAPTGDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J9</accession>
    <name>R4W7J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCAIR mutase (PurE)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447846.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15090"/>
    <dbReference type="EnsemblBacteria" id="AGN02952">
        <property type="protein sequence ID" value="AGN02952"/>
        <property type="gene ID" value="L593_15090"/>
    </dbReference>
    <dbReference type="GeneID" id="16181732"/>
    <dbReference type="KEGG" id="sali:L593_15090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3082"/>
    <dbReference type="eggNOG" id="arCOG02465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_2"/>
    <dbReference type="OrthoDB" id="73714at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="25652" checksum="ACD819FE6E257857" modified="2013-07-24" version="1">MRDILDAVASGDLSPAEAEAELTGYASVDAGRFDAAREQRRGVPEAILADGKTAAEIAELATTAVATAGRAIVTRIDDPAANAVAAILSEEAPEATVRWNDRAKMLVAHAPSYEPPRFDATVGIVTGGTSDAEPAGEAAMIAGEMGARVDLIEDVGVAGIARVLDRLERLRESDVLVVAAGREGALPTVVAGLVHVPVIGLPVSSGYGFGGEGEAALAGMLQSCTVISAVNVDAGFVAGAQAGLIARAVAGAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7P7</accession>
    <name>R4W7P7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD-related deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445992.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05745"/>
    <dbReference type="EnsemblBacteria" id="AGN01098">
        <property type="protein sequence ID" value="AGN01098"/>
        <property type="gene ID" value="L593_05745"/>
    </dbReference>
    <dbReference type="GeneID" id="16181489"/>
    <dbReference type="KEGG" id="sali:L593_05745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1176"/>
    <dbReference type="eggNOG" id="arCOG00893">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985571_0_0_2"/>
    <dbReference type="OrthoDB" id="47746at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011589">
        <property type="entry name" value="UCP004961"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206">
        <property type="entry name" value="PTHR42206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004961">
        <property type="entry name" value="UCP004961_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="30973" checksum="A73ED11E63754D30" modified="2013-07-24" version="1">MPEYDGAILDDHLHLSPERGRGVDAVETFAEAGGTHMLVVNLPSWHYGVEIEAPEDFRVGFESTIGVVEDASEVLSGRAWPVLGVHPGLLSRLVDDRDFEPEEARDLLQAGIDVAADYVADGPALALKSGRPHYDVPDPVWAASNAVMRHAFETAAELGCAVQLHAEAGEDFSQVAEWAEDAGLPRGRVVKHYAEGRLEGPVPSVICQKDRLETAAERAETEDEPFLMETDFLDDPDRPGAVMGPKTVPRRVEWLLEQGHADAIRTAHVDTPAAVYGIDTEATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R1</accession>
    <name>R4W7R1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">L593_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00145"/>
    <dbReference type="EnsemblBacteria" id="AGM99983">
        <property type="protein sequence ID" value="AGM99983"/>
        <property type="gene ID" value="L593_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00145"/>
    <dbReference type="eggNOG" id="arCOG10788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690054_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="399" mass="42838" checksum="467A09A762B8288F" modified="2013-07-24" version="1">MQEYVAVLRGIGLTESAIVDAHGDRERPDGPLQSYPAETLPGTDELELHDALGDAIAASARGIDAPAEYWNHAPEVHLDELLAPYDCSITIQPSQWADTLADGKFIVRLRDANGTEFWTRFEYPDSDLGSDNYPALLHHVEEQLLAPAGLRIVRLVAPRGRWRFAMMSVEQLAALRNRYGERLRIFGAPLLAADQPPAFANEHPPVPRWYDADEDVEPASDDDLSLDVPATESLDDLEPSDADLELDESPETIIESVENADAGSGTTGSVTADADVEASDDQVESVFGDLSDVSLEPEDPDPEPTTGGSSGGTLAIDGGAAAATGADDPIDDLFDEMKRDIADSEVETGENADAGNDASIADLVENVEESPRANDERDDVPQDAADLTASELFSSLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W833</accession>
    <name>R4W833_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07565"/>
    <dbReference type="EnsemblBacteria" id="AGN01458">
        <property type="protein sequence ID" value="AGN01458"/>
        <property type="gene ID" value="L593_07565"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07565"/>
    <dbReference type="eggNOG" id="arCOG03293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575010_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="17546" checksum="F5A5A33282AA2F10" modified="2013-07-24" version="1">MSNEDGPEDSSGDETGPETGDAGGRDDDAGGTDDGGEAAGASAVNGGDGDTPGADDAGTDDDRETPGPDEQYCASCGEIIERRAEICPHCGVRNRNAPSTARTDRTTAGILAILLGGIGAHKFYLGETGLGILYLCFVWTGIPVVIGIIEGILYLTKTDEEFERKYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W847</accession>
    <name>R4W847_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445203.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01790"/>
    <dbReference type="EnsemblBacteria" id="AGN00309">
        <property type="protein sequence ID" value="AGN00309"/>
        <property type="gene ID" value="L593_01790"/>
    </dbReference>
    <dbReference type="GeneID" id="16179945"/>
    <dbReference type="KEGG" id="sali:L593_01790"/>
    <dbReference type="HOGENOM" id="CLU_2730576_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="8149" checksum="A3FD5068508FC4FD" modified="2013-07-24" version="1">MRSRTEALREYVTYTLLLWVVINFVVFRFLVGSDLFVESAASLALAGPLGYLVFDYSNSRLPDCEPTSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W852</accession>
    <name>R4W852_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446392.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07765"/>
    <dbReference type="EnsemblBacteria" id="AGN01498">
        <property type="protein sequence ID" value="AGN01498"/>
        <property type="gene ID" value="L593_07765"/>
    </dbReference>
    <dbReference type="GeneID" id="16182216"/>
    <dbReference type="KEGG" id="sali:L593_07765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1591"/>
    <dbReference type="eggNOG" id="arCOG14874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718265_0_0_2"/>
    <dbReference type="OrthoDB" id="105766at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="163" mass="17594" checksum="04437092F31B7E0D" modified="2013-07-24" version="1">MGEHARQVQERLADRLAAALPAAEWSVERPVGGTPVDVAGETPDRLVLLELEWRRADPANNTAKLFRHLADDGALRAVLGDRDAVVVQLFTNYYDLASGGVSSKRRDATFVGAAAAEYLDNVAYWPVDLSIDPPKGGGELPEDWNAAVDAAVDSIVDRLEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W885</accession>
    <name>R4W885_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagella protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445313.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02340"/>
    <dbReference type="EnsemblBacteria" id="AGN00419">
        <property type="protein sequence ID" value="AGN00419"/>
        <property type="gene ID" value="L593_02340"/>
    </dbReference>
    <dbReference type="GeneID" id="16180176"/>
    <dbReference type="KEGG" id="sali:L593_02340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.474"/>
    <dbReference type="eggNOG" id="arCOG02963">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030327_0_0_2"/>
    <dbReference type="OrthoDB" id="63937at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006752">
        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009205">
        <property type="entry name" value="FlaC_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05377">
        <property type="entry name" value="FlaC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
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        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="519" mass="55431" checksum="85BA8CFAED033E4F" modified="2013-07-24" version="1">MVALDPAPLADAAVAVASPAAVAGSLAALGVLGVTDWILGDDDPPEGADESGGDAGSGMFDEPETAGDGGIAGMGDDDGGDEFAFDDDEGGGDAFDEFDVGGMDDAGGGGSAQVRELEGRVDEIEDELSSISSTVSTVRTENEQISESVDDIEENVRKLLDIYKMVTKGVNPFVDEDGANGFAGGEGASLGLFDQGQDDEEQPGQLDEDVTDANAEEFFDDDFEEDEVPEEDEAPEVEEEEEEDADDTEESMAQSDDAPTDEEGGAKSFDELREEYEDGADWSEEDAAADEEPEAEVGQETEVESETEEEVEPNPVEEPAKIEDEQDTHATEGGVDDEGAADERVDALFEEDDELQAEEPEPEPEPEPAHETGAHQPPAQPASQPAPQPPRTGARQPAMGGAGGEKPYLRELPSGYVSDLLVMEWIEFLVTESSPSGAHRAITYYENVGWIGHRAADQLREFVDGHPEASVDEDEPAGTGALTMDHHTTSLRYVARITGDVQENVLDSWDEGDNRWLHR</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="94" mass="9734" checksum="362F42DFAC7369F7" modified="2013-07-24" version="1">MGASDPGDDDPNADGDGPSDDEVVQTAAEAAEQVVFSRFGRSDVSDVDISVNFEDGILEVDVYIEADGDADPEQVADDAALAAQGAVDDLFDEP</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <sequence length="223" mass="24443" checksum="2C951CC3CCF5A755" modified="2013-07-24" version="1">MSTEPAPTDLTIACHVRPTLVLEPIDAKIETLRQCERDGTIDSLLLRSWPGEVAMLEDTPHPEVLDQYDRFTDWADRADVSIHPPFQTRETTSIASERTIDRLVTPTICLAVYDRDRLVGVFPHSDGETTYTVPEAIASLRTGELPEALLRRGGVAERTTPRPATAPPSGDLPSWNRPTMAAGESRPACPDCGDDLTNVQGILDCDGCEWIGADRTIPLVTGR</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Toshchakov S.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="16"/>
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        <source>
            <dbReference type="EMBL" id="AGN00704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="51" mass="5432" checksum="7B14BB42F2853017" modified="2013-07-24" version="1">MAVDDRFGLRSPGELRSLHTSGTSEPSRSTGSHDTAQPGIGRLTPQSLNRP</sequence>
</entry>
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    <accession>R4W8M2</accession>
    <name>R4W8M2_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <location>
            <begin position="32"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01933.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="183" mass="19573" checksum="0B6D3EEBBF20FFAD" modified="2013-07-24" version="1">MRRLMLAIGSASTAAGATLVLTPMSAPVAPPVVPALGLVVVLGLALGGLGAVRRARERPAATSLADTRDRTAVDAPGDAFDRTLASISARVDEEERAPVRDRLAATAVQVVADAEDCSRETARRRIDRGTWTDDRAAVAFFADSVEHAPSLRERVRRVLAGEPTFAVRARRVIDELADREREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M9</accession>
    <name>R4W8M9_9EURY</name>
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        <submittedName>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01948">
        <property type="protein sequence ID" value="AGN01948"/>
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    </dbReference>
    <dbReference type="GeneID" id="16179870"/>
    <dbReference type="KEGG" id="sali:L593_10015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2064"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="157" mass="17007" checksum="271B116216E67E29" modified="2013-07-24" version="1">MPSTGDHAPRFDATLGTSDHEDFSLADHLGDGPVVLAFFPGAFTPPCSNEMVALQERIDEFHAADATLFGVSADSPFCQGAFREEHGLAFDLVSDTSGDVIRAYDLDIDIPDLGLYGVANRAVFVLDDDGEVAYEWESADPTHEPPYEELLEAVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V2</accession>
    <name>R4W8V2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dnaJ</name>
        <name evidence="12" type="ORF">L593_10840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447007.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10840"/>
    <dbReference type="EnsemblBacteria" id="AGN02113">
        <property type="protein sequence ID" value="AGN02113"/>
        <property type="gene ID" value="L593_10840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181554"/>
    <dbReference type="KEGG" id="sali:L593_10840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2237"/>
    <dbReference type="eggNOG" id="arCOG02846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_2"/>
    <dbReference type="OrthoDB" id="50583at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="42918" checksum="F7642C0F0526158E" modified="2013-07-24" version="1">MSEDFYDILGVSRDADEDEIQQAYRKKAAEYHPDVSDDPDAEEKFKQAKKAKEVLTDEEKRQAYDQLGHERFEEAEKRGGFDQGPGGMGGQGPFGGMGGQGPFGGGAGGGQGFGSVEDIFEQFFGGAGGGRGGGSRRRQGSDLRTSLEIDLEEAYHGVEKQMTVERPTECDECGGEGHPADAEARTCPECDGRGQVRQVQQTPFGRVQQTGTCQRCAGDGEIYDETCSECRGEGIVREETTLSVEIPAGIQDGQTLRMEREGAPSPTQGPNGDLLIDVTIADHPEFEREGDDLHYHKGLSFPQVVFGDTVTIPTIDGEVELEIPAGTQSGEEFRLAGEGMPRLRRRGEGDLYVTAQVVTPESLTEEQQEALEAFAEAGGEEIEVDQSFLQKIKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A3</accession>
    <name>R4W9A3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pilin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447402.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12845"/>
    <dbReference type="EnsemblBacteria" id="AGN02508">
        <property type="protein sequence ID" value="AGN02508"/>
        <property type="gene ID" value="L593_12845"/>
    </dbReference>
    <dbReference type="GeneID" id="16180204"/>
    <dbReference type="KEGG" id="sali:L593_12845"/>
    <dbReference type="eggNOG" id="arCOG02416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021598_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="122" mass="12762" checksum="4796A2BC43DD1D68" modified="2013-07-24" version="1">MGVVLLVGIAVMLMTTVGVFVLGFGPGEQPPESDMQFHQESGEVVISVVRPAGLSEQDVVVTVENSGDCAWTGTGALQKAETVTISNSTPNCPTINQGDTIRVIWEAEGGGRTAIIGEYEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B5</accession>
    <name>R4W9B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07010"/>
    <dbReference type="EnsemblBacteria" id="AGN01349">
        <property type="protein sequence ID" value="AGN01349"/>
        <property type="gene ID" value="L593_07010"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1434"/>
    <dbReference type="eggNOG" id="arCOG01393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059497_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="334" mass="35130" checksum="58F7CC98D8257B81" modified="2013-07-24" version="1">MTTAGERASGGSDEPDGEPIAVGHYCEGAGHATRMLAVAEALADRGYDFEIAGGGPGEPFVEANGYTERPLPEVDFVGGYQSDNGSHVVFDGLPNFIRRVRAYVAWLNEVEPPVFLTDDICGCFAASVARQRYVYVSHDPAAFYDSPPERASAWIRNRIPAVTAESFCFPKAWEGDPWIETATPVGPIAPADDTPEADLPDVDVLVVPSAFSVDEDDLDAALADAGRTATIVGGEDWTLKPSLQPYVRAADLVVCSGYSTVMEAAVAGTACVVMPATSEQRGVAAAMEGTRGFATAETIEEVVALLGTLDAPEPQANGAEEIADAVVDAIETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H4</accession>
    <name>R4W9H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13620"/>
    <dbReference type="EnsemblBacteria" id="AGN02663">
        <property type="protein sequence ID" value="AGN02663"/>
        <property type="gene ID" value="L593_13620"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2788"/>
    <dbReference type="eggNOG" id="arCOG00671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="26564" checksum="24AF585C98E5376A" modified="2013-07-24" version="1">MTPEYRFGMRPRFVGRTGLADAVTVANAILGFLAIVVATTDTWTAARLLLLAAILDGLDGVVARWRGGTAVGPYLDSLADVVSFAIAPAVLVYAVAAEEWGIAPLESAEPRAVVAFLLPALFVGAAITRLALYTAYDTDEEYTEGVQTTLAATLIGAAVLTGITRPDILLVITAAFVYLMLSPLRYPDLLARDALVMGVVHALAVLVPLALQRAFPWALLFLGLGYLVFGPWLYWRESFPLPIPSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N7</accession>
    <name>R4W9N7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="10">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="10">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">pheT</name>
        <name evidence="13" type="ORF">L593_08595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446558.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08595"/>
    <dbReference type="EnsemblBacteria" id="AGN01664">
        <property type="protein sequence ID" value="AGN01664"/>
        <property type="gene ID" value="L593_08595"/>
    </dbReference>
    <dbReference type="GeneID" id="16180784"/>
    <dbReference type="KEGG" id="sali:L593_08595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1760"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OrthoDB" id="55024at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00284">
        <property type="entry name" value="Phe_tRNA_synth_beta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022918">
        <property type="entry name" value="Phe_tRNA_ligase_beta2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="12">
        <location>
            <begin position="297"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="620" mass="67624" checksum="373CDBE478C0B3AF" modified="2013-07-24" version="1">MPVVEIDTDELLTLAGHEDKPEDELIDDLFALGLELEGKTEDGDLELEFAPDRLDRLSVEGIARSLRYQYGDDRGAYVPSVTDPDWTIEVDSDVPDERPYVTGAVLRDVNLDEDALESLIQLQEKLHATMGRGRAKGAIGVHDLTMLKGAVGPTDEEDAAEPNNSVRYTGIAPDGDTFVPLESDREMTPGEALESHHMASEYADLVAEYERMPAIYDDLGLFSFPPAINGRRTEVTAESRNLFVEMTGTDQWTIDRMLAILCYAMDARGATIEAVDVSYADDAGGEYAGTTIERPDLSLDRKTVAHERVESVVGVDFDPDEVLDLLERSGLDAEQIELQRGDAGEEGDVAAGYEVAIPAYRVDVLHAQDLIDDVGRAYGFNELDASYPDVSTLGGRHERSRHERAVRDTLVGVGFEDMLNFHMTNEAETFGRMGLPIPEVGHVDLQAEEMEISGHAGEHADREVADDAVGFAPAPTIATAYSEDYTVLRTWALPSLLQVLEGNTHREYPQDLAEVGFVAQVDPTEPTGVAEHRSVAAVVARHDASYEDARGRLQALASAFDVELETPATEHPSFLDGRVADVVVDGEVAGVIGEVDPAVLVEHDLEVPVAAFELRRDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q0</accession>
    <name>R4W9Q0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446583.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01689">
        <property type="protein sequence ID" value="AGN01689"/>
        <property type="gene ID" value="L593_08720"/>
    </dbReference>
    <dbReference type="GeneID" id="16180871"/>
    <dbReference type="KEGG" id="sali:L593_08720"/>
    <dbReference type="eggNOG" id="arCOG04573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978673_0_0_2"/>
    <dbReference type="OrthoDB" id="86761at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="284" mass="31057" checksum="C0AF68B738493702" modified="2013-07-24" version="1">MVGDHSRGDPTADAGDESSGGEGEDTSVPFGGEQVAEGEEFEEFRTDVNRAFPEDELSLEELMALPPGEGAAETDDPAPAAPDRTDGAGPDSEPADVDESPPAAAESPPDDVLARFVDAVDSRDLTETERDRLRSALGLETTTSTEVRVRHLQSNLADLEAYVDAMEAFIDERGTARTLLDRHEGRVEDLRSTLDRHDEGLAELRTGFVDHEQRIETTDSRVGAVEERVDELEADRDRLDACVESIELLVQYAEEFGARLDDVEEWQDRVERAFAEVPGPESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W0</accession>
    <name>R4W9W0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 18" type="primary">hemA</name>
        <name evidence="18" type="ORF">L593_09720</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446783.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09720"/>
    <dbReference type="EnsemblBacteria" id="AGN01889">
        <property type="protein sequence ID" value="AGN01889"/>
        <property type="gene ID" value="L593_09720"/>
    </dbReference>
    <dbReference type="GeneID" id="16182762"/>
    <dbReference type="KEGG" id="sali:L593_09720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2001"/>
    <dbReference type="eggNOG" id="arCOG01036">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_0_1_2"/>
    <dbReference type="OrthoDB" id="48038at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="173"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AGN01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="47484" checksum="F040E581CD19B8A2" modified="2013-07-24" version="1">MFGGTGVITGVSVAHEHATVDEIAEAGAENQRAEIACLTARDGVEEAFALQTCNRAEAYVVTTDAADGRAALQDFAPSVREEAVTRMDHEESLRHLMRVAAGLESLVLGEDHVLGQVREAYQDARGVGGIGPTLEEAVTKAIHVGERVRTETAINEGIVSLGSAAAAFAADEVDLEGATAAVVGAGEMGTATAKALANRGIDELLVVNRTVPHAEHVATAVDVDAEALGLPSIHTVLETAAVVVTSSASEEPLIEPHHVAGIDATTFVDLAQPRDVDPGVASRAPVTVYDLDDLEDVTEQTRRQRRAAAETVETIIDDEFDHLLERYKRKRADEVIAGMYEGAEAIKRGEVERAIEQAEADGDLSADQREAIEAMADALVNKLLAAPTSSLRDAAAEDDWTTIQTALQLFDPTVEDGPSVGDEAPPGFSGDAAGVASSDEETDSTPTPVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA10</accession>
    <name>R4WA10_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="1 2">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gch3</name>
        <name evidence="3" type="ORF">L593_10970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447033.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10970"/>
    <dbReference type="EnsemblBacteria" id="AGN02139">
        <property type="protein sequence ID" value="AGN02139"/>
        <property type="gene ID" value="L593_10970"/>
    </dbReference>
    <dbReference type="GeneID" id="16182540"/>
    <dbReference type="KEGG" id="sali:L593_10970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2262"/>
    <dbReference type="eggNOG" id="arCOG04202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080076_0_0_2"/>
    <dbReference type="OrthoDB" id="56576at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="PTHR42202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="27113" checksum="2AAF67E129B26BF2" modified="2013-07-24" version="1">MTATQVTLFQLDNYGPWTVTPEPRPEPELQALQARLYADLADAVGDRGGYVFVTRFDNVVAVTNGLDREDHGAIQTAIDERYPVTVSAAIGTDERPAAALAEATALLQERGSAQDAARTEVLAGQPLGSSDDGGSTVRVAHFDVVDVTGQLTDSVDAYGAHLEVQGATHALSTHLYERHDALAFFVGGDNVIAICPDLDASDYEAAIEHVADEVGVAFQVGIGEGATASEAGMEAKFALEACRRDGSRIEGLAVPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA47</accession>
    <name>R4WA47_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ORF">L593_11905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447218.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11905"/>
    <dbReference type="EnsemblBacteria" id="AGN02324">
        <property type="protein sequence ID" value="AGN02324"/>
        <property type="gene ID" value="L593_11905"/>
    </dbReference>
    <dbReference type="GeneID" id="16181966"/>
    <dbReference type="KEGG" id="sali:L593_11905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2450"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OrthoDB" id="128352at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="11820" checksum="B892B16597E1F5B0" modified="2013-07-24" version="1">MEYVYAALILNETGEEINESNLTDVLEAAGVDVEESRVKALVAALEDVDIDEAVAEAAAVPAGGAAAGGAAEGSADEAEDEEDEEVEEADEDLPDTTDDDEEEEASGEGLGDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA87</accession>
    <name>R4WA87_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SelT/selW/selH selenoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447418.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12925"/>
    <dbReference type="EnsemblBacteria" id="AGN02524">
        <property type="protein sequence ID" value="AGN02524"/>
        <property type="gene ID" value="L593_12925"/>
    </dbReference>
    <dbReference type="GeneID" id="16180221"/>
    <dbReference type="KEGG" id="sali:L593_12925"/>
    <dbReference type="eggNOG" id="arCOG06207">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_5_1_2"/>
    <dbReference type="OrthoDB" id="116512at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="76" mass="8513" checksum="F0EABD232AEC5DEA" modified="2013-07-24" version="1">MTDVEIHYCVPCGHLDRAQQLQYAILDQYGQDVDRVALRTGDGGVFTVSVDGEQVFDVDEDEYDADAIVESIDERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAH2</accession>
    <name>R4WAH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447843.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15075"/>
    <dbReference type="EnsemblBacteria" id="AGN02949">
        <property type="protein sequence ID" value="AGN02949"/>
        <property type="gene ID" value="L593_15075"/>
    </dbReference>
    <dbReference type="GeneID" id="16182709"/>
    <dbReference type="KEGG" id="sali:L593_15075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3079"/>
    <dbReference type="eggNOG" id="arCOG03917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153002_0_0_2"/>
    <dbReference type="OrthoDB" id="127736at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="87" mass="10201" checksum="D00AB6B45E601A6C" modified="2013-07-24" version="1">MSEESVRCWLVERDYWDEDVVTLVYATPDGELFHQRQLAANLVFGLDVTAAKEFDREDLEPTPEADRERYAEEASKVRERHDPDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS02</accession>
    <name>R4VS02_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGM99984">
        <property type="protein sequence ID" value="AGM99984"/>
        <property type="gene ID" value="L593_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00150"/>
    <dbReference type="eggNOG" id="arCOG03924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171547_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="11993" checksum="BE4651B5397540C1" modified="2013-07-24" version="1">MLEALHSYGRNVAPNIAEITGKSRKNVNNRLPVLDDYGLVRKIGPADRSGLYEITEQGRVALQLRDQYDAAEDFDALVDRRLESQSASATTAEATVRGGNDDDEPTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS64</accession>
    <name>R4VS64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444954.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00060">
        <property type="protein sequence ID" value="AGN00060"/>
        <property type="gene ID" value="L593_00525"/>
    </dbReference>
    <dbReference type="GeneID" id="16181754"/>
    <dbReference type="KEGG" id="sali:L593_00525"/>
    <dbReference type="eggNOG" id="arCOG04394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_2_2"/>
    <dbReference type="OrthoDB" id="121002at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="12050" checksum="9184D52424E303A6" modified="2013-07-24" version="1">MQTVFHVSSPESDVRRHAMVNVTNLLEDDTTAAPDDDVAIVANGAGVRMFVASTAANGELVASLVERGVECFACGASLAKMNAITADLLPGVERVQSGVGALARLQDEGYGYVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSQ7</accession>
    <name>R4VSQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445099.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01260"/>
    <dbReference type="EnsemblBacteria" id="AGN00205">
        <property type="protein sequence ID" value="AGN00205"/>
        <property type="gene ID" value="L593_01260"/>
    </dbReference>
    <dbReference type="GeneID" id="16180248"/>
    <dbReference type="KEGG" id="sali:L593_01260"/>
    <dbReference type="eggNOG" id="arCOG07569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135997_0_0_2"/>
    <dbReference type="OrthoDB" id="98919at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="14481" checksum="401F74F69F3F50A7" modified="2013-07-24" version="1">MGALLADEVAERIRSVSRTALGESCRSVTYFTKDDFEQLYLRDDLEKDADLTGFIGHEWRGFRLTQAAYEGTELGKYKYTVRAFENGYLIRVTGDREGVFVTTDPRPLHDFETVADALREVFREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSZ6</accession>
    <name>R4VSZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">A-type ATP synthase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445209.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01820"/>
    <dbReference type="EnsemblBacteria" id="AGN00315">
        <property type="protein sequence ID" value="AGN00315"/>
        <property type="gene ID" value="L593_01820"/>
    </dbReference>
    <dbReference type="GeneID" id="16179960"/>
    <dbReference type="KEGG" id="sali:L593_01820"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_6_0_2"/>
    <dbReference type="OrthoDB" id="130056at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="8655" checksum="53429C2C50EDBFF4" modified="2013-07-24" version="1">MFDIAADTASIVLQQEGIQKLMLNNSGAAAIAVGLAAIGTGYAQRGIGSAAVGAVAEDDDNLVPGLIFTALPETLIIIALVTIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT40</accession>
    <name>R4VT40_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445259.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02070"/>
    <dbReference type="EnsemblBacteria" id="AGN00365">
        <property type="protein sequence ID" value="AGN00365"/>
        <property type="gene ID" value="L593_02070"/>
    </dbReference>
    <dbReference type="GeneID" id="16179948"/>
    <dbReference type="KEGG" id="sali:L593_02070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.421"/>
    <dbReference type="eggNOG" id="arCOG00753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_0_1_2"/>
    <dbReference type="OrthoDB" id="9099at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="5">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="407" mass="43394" checksum="E52B8A650A9ABB17" modified="2013-07-24" version="1">MDQPTVLVVGGGATGAGIARDLALRGVDVTLVDRDGLGSGTSGRSHGLLHSGARYAEADRVGAEECIVENRILRDVAGECVRDTGGLFVQLADDDPAYFDAKREACESVGIPRTVLDADEARASVPDLADDVVRALEVPDGVMYPSRLVAANAADAREHGATMLLDAPVDGMTVEDGRIEAVRLGGSVDERIGPEYVVNAAGAWAGRIAAMANLEVEMRPTRGVMVSVEYDDLGPVLNRCREPDDGDIVVPHDSEVVLGTTSVAVTDPDDYATEEWEVARTYEECAAMLPPVVDAPEVRTWWGVRPLYAPDEDERGGRGISRGFFRLDHAEDGVENLVSVVGGKLTTYRQMAEATTDLVCERLGVDAECTTADRRLPGADDPDRLDAFVAEFDGQGPTDEDVVHGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTP9</accession>
    <name>R4VTP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445504.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03295"/>
    <dbReference type="EnsemblBacteria" id="AGN00610">
        <property type="protein sequence ID" value="AGN00610"/>
        <property type="gene ID" value="L593_03295"/>
    </dbReference>
    <dbReference type="GeneID" id="16180489"/>
    <dbReference type="KEGG" id="sali:L593_03295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.667"/>
    <dbReference type="eggNOG" id="arCOG04595">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968400_0_0_2"/>
    <dbReference type="OrthoDB" id="40913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="30894" checksum="0252ECF0B5649BF1" modified="2013-07-24" version="1">MDDPYDKYPEDSDRRRFVKGVVGAGALTGVIGASASLVDISTAPPGAGGGPTDYMGIEKTGGPAPRGMPQIPLEYDSDGNLKGVWPEVEMQEIGGRPVPVAEMELGGRTYSTTWYQYCGSQNNPAIKPDADLDNTIRYTANPAYEWQSNAVSAGDPVRKEHFEDYADWGNNIGEGGVGKPAKVTWRSTELEPKNRIPVQLIRSPLIERKAENDDWLAASTVDGFMAVHNQCTHFCCVPGFKDPDQTDALAYNAGDKIYCQCHQSVYDPFAIIQQDMIALPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTQ3</accession>
    <name>R4VTQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03320"/>
    <dbReference type="EnsemblBacteria" id="AGN00615">
        <property type="protein sequence ID" value="AGN00615"/>
        <property type="gene ID" value="L593_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.672"/>
    <dbReference type="eggNOG" id="arCOG04598">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648264_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="21377" checksum="7EC2179FEE5D871F" modified="2013-07-24" version="1">MGPSIDAVASSAELFVGASVLASYGGLIDGVPKSTEIATVVALFVTASLPFYLYGAWIVIDAEVVTWSVLTHHLKFISVGLTLTTVPVVTWMVPRLIEGFTGTVAMHAFFGLQAYALLLFALTGIFHIFRAKRAHSLYEDPDQDVDISELHENMGAWRFRLRVGVFGYVLTWLIAWLLGLVILFLRWERFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTV8</accession>
    <name>R4VTV8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445554.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00660">
        <property type="protein sequence ID" value="AGN00660"/>
        <property type="gene ID" value="L593_03545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180587"/>
    <dbReference type="KEGG" id="sali:L593_03545"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_0_2"/>
    <dbReference type="OrthoDB" id="79655at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="36246" checksum="147C739AEFDFFFFB" modified="2013-07-24" version="1">MTDFEWLSENAVLLLLFVVFGLLSVALVFPFFQAILAAGLLAFLLVPVSDRLSRRLGPTAGALVTVFLLLLLVLVPVVLVLRIAIEQAVALAETASIPDDAFLETLLRDYLGVERDLSSFEQQLGEVARRAFSGLVGGLYGFLAGIPALLVNAFVFTFALFYFLRDGDRLVAWIRETLPLDAATTDHLVARTDDLLWSAVVGTIVVAGLQAVLTVLGFLVLGFDDLVFWGVVTFFLSLLPLIGASIVWIPATLLLAAEGRPTAALALGVYGAVIVSGSDNVVRPLAMQRGAGLNSGLLVLGIFGGVAVFGFMGLFVGPVVLGLTVTILELLLDEDAELTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU60</accession>
    <name>R4VU60_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase IV</fullName>
            <shortName evidence="11">Pol IV</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dbh</name>
        <name evidence="14" type="ORF">L593_03895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03895"/>
    <dbReference type="EnsemblBacteria" id="AGN00730">
        <property type="protein sequence ID" value="AGN00730"/>
        <property type="gene ID" value="L593_03895"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.791"/>
    <dbReference type="eggNOG" id="arCOG04582">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="566" mass="60260" checksum="B47FBA5AB43B49C3" modified="2013-07-24" version="1">MTDRVTGAYYEDSTVQQGPTLPGVETGDDEDRIVLHVDLDCFYAACERLREPKLAGKPLVVGMGYEGGQPDGAVATASYEAREHGVESAQAISTALERLPRAADHPDGIEAESDGPDAVGYYRPVDMAYYQEIAAEIKEILHNCAETVREVSIDEAYLDVTDRTEWSVVEGYARHVKQRIDREVGLTASVGVAPTMHAAKVASDHDKPDGLVVVEPGDVEAFLAPLPIDDLHGIGPVTASTLREHGIETVADLADADREWVHEQWGDRGLELYERARGIDPRSVEPRGRPKSLSRESSLGGAEDDFDAVEQRIRTLAEAVAERARSKEALYRTIGIKVVTPPFDVNTRAQSLPGPVDDPDLVETVAIDLLEEFEDATPRKVGVRVSNLSFADADQSTLGGWDGDSTATDPDDREAVEPAEVGTDASADSSMDSPADSPMESPPESPLGSPGDSPTESTLDSSAESTLDSSAESPAASSTGSHTESPGAPSTTSFTTQSTESPDTPPTESPNTSSAGPPDESSTESPDDGQPGQSVLDRVWSDGPAERADPEPIGQPPDQTTLSEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUN3</accession>
    <name>R4VUN3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="8">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpA</name>
        <name evidence="10" type="ORF">L593_00080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444865.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00080"/>
    <dbReference type="EnsemblBacteria" id="AGM99970">
        <property type="protein sequence ID" value="AGM99970"/>
        <property type="gene ID" value="L593_00080"/>
    </dbReference>
    <dbReference type="GeneID" id="16181821"/>
    <dbReference type="KEGG" id="sali:L593_00080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.16"/>
    <dbReference type="eggNOG" id="arCOG01086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_2"/>
    <dbReference type="OrthoDB" id="65368at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGM99970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="288" mass="30661" checksum="A9078E3AB77B1DA0" modified="2013-07-24" version="1">MSETDPGTGADSTLAEAFADGPAFVPYLVAGDPDFETSREYLEALDRGGADVIELGLPFSEPIAEGPTIQSAIVRALEAGMTPDRFFELAESLDVDASLVCMTYYNLVYQYGTETGPRPFVERAAEAGIEGLVVPDLPAEEADELRAACDEFGLDLIFIVAPTTDGERLERMRELVSGYVYVQARLGTTGARNDVSDQTSSSLDRLADWEVPKAVGFGISSGEHAERIVAGGADGIIVGSALVDVVAEGVETERPVRETATRLEELARELAEGAVAGARKNRPEPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUU3</accession>
    <name>R4VUU3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00405"/>
    <dbReference type="EnsemblBacteria" id="AGN00036">
        <property type="protein sequence ID" value="AGN00036"/>
        <property type="gene ID" value="L593_00405"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.82"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_7_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="28244" checksum="2B128DF02634B54C" modified="2013-07-24" version="1">MALAGQVPVMDLGVTVGDSIDRLERTGVDFDFVEVSVGEAQPLPTDAAAPRLRSALAATESDLCMHLPFQQVVATPVEQLNDAIVEYLEDLLSWGGTVGARKAVLHATARNPYDTDLRPTIAEQLRRIAAVGEEHGVEVVVENVGHQKQGVQLSVLADLAREAEVPICFDVGHAYMEEGDDGIDRFCSRNADRISHLHVHDARSRGDTHIPIGAGEVDWSLLEEHLDDFDGTVAVEVFTDDLSLLRDSAERVTDLFGQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV68</accession>
    <name>R4VV68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446024.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05905"/>
    <dbReference type="EnsemblBacteria" id="AGN01130">
        <property type="protein sequence ID" value="AGN01130"/>
        <property type="gene ID" value="L593_05905"/>
    </dbReference>
    <dbReference type="GeneID" id="16181541"/>
    <dbReference type="KEGG" id="sali:L593_05905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1210"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_3_2"/>
    <dbReference type="OrthoDB" id="101975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20832" checksum="A5C40FEC0B1342BF" modified="2013-07-24" version="1">MSEDDAPNDEIVIRRAEPADAPRIRELNEVALRQVDAYAEDAVEEGMDEDLEDVEANYVAVGGDFLVAEIDGDSQAEADAPSIVGMGALEPVGDATFQADAIVRPGDEPAGEITRMRVDPEFQRRGIATRLVDRLEERARELGYATLVLDTTARQEGAQRLYEGFGFEHEDTVQWREYEVLLYRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVK1</accession>
    <name>R4VVK1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_01615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445170.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01615"/>
    <dbReference type="EnsemblBacteria" id="AGN00276">
        <property type="protein sequence ID" value="AGN00276"/>
        <property type="gene ID" value="L593_01615"/>
    </dbReference>
    <dbReference type="GeneID" id="16179875"/>
    <dbReference type="KEGG" id="sali:L593_01615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.328"/>
    <dbReference type="eggNOG" id="arCOG00168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504004_0_0_2"/>
    <dbReference type="OrthoDB" id="86965at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="362"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="585" mass="59971" checksum="08ECF4940A7FC8BC" modified="2013-07-24" version="1">MATDHSTDFGHVSRLRGTLFEALSLGSSLLGIVTLGILLAIVSVDALGLDAADGGWILTIVGLVVVPPLALCTVGLDDAAVRVRAAAALVLGVPAAFAAELAFGAIGVNAALLEWQLLYLFTVVLPVAGVVLSAGTRSPVGSVAMGFLGRAIGGLVLGAAILILFVVVEPQLWFLLYTLGVLPFVAITVYARRHPDTRLGIARVPAAAVGAAAAIAIHQFLIFYTPYWVFHVWSLAIPAAVAVGLTYRSARPDASGVIAGGVTALALVFGSLGIGALGLPPSYALFVLLGLIPAGLYAERAVGSHPSRLGLAVPLVLIAGVALALGLVDVLSLAGPEPWLDWQFLTSVKGSPAEAAGFYPAIVGSVVVIALVALLSFAFGVGTAVFLEEYTADEGLVGSITRLVQVNIANLAAVPSVVYGLLGLAVFANMLGLGLGTIVTASLTLSLLILPITIISAQEAIRSVPDDLRRGSDAMGATRWQTTKNVVIPQALPGIFTGTILALGRAIGETAPLILIGAASSTTSAPSELFDTAIAMPLQLFAWYNNPGAFREGVVPAGVVTLLAILLVMNGTAIVLRNKYERADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVN7</accession>
    <name>R4VVN7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_01825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445210.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01825"/>
    <dbReference type="EnsemblBacteria" id="AGN00316">
        <property type="protein sequence ID" value="AGN00316"/>
        <property type="gene ID" value="L593_01825"/>
    </dbReference>
    <dbReference type="GeneID" id="16179961"/>
    <dbReference type="KEGG" id="sali:L593_01825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.370"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_2_1_2"/>
    <dbReference type="OrthoDB" id="14889at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="735" mass="79943" checksum="54BD492FCED2733D" modified="2013-07-24" version="1">MLRPERMSKVSVTGSKSILDEVIDALHELNRVHLTDYDGSWEAFDNGDPSEGADEASERLVTVRGLESTLDLDDEELPPERGFDPSTLGERLAEVRSSVNDLDDRRQELRQELRTVEERIGSMAPFARLGIDLDLLTGYDAIEVVVGEGDEDSIRSAYEASDDVRAVELFGGDGVVAAAVAPAEGVDMEDAAADPLVGVDFTRIEVPDSEGSPEDAVENLRTEKRRLEAEIESLNAELREQKLEVGGFLLAAEEYLTIQVQKGEAPLRFATTENSFVAEGWIPTAELETVEASIRDAVGDHVEFEELERAAYDRHGEVAHHDDVAEESGGDGVATAGASAGAETTADAAEESDEQVAADGGVVTVRDDPPTVQRNPEPTTPFEVLVQAVGRPNYGELDPTIVLFLTFPVFFGFMIGDVGYGVIYALIGLFAMRRFDSDAIQQFGVVVVWAGILTIAFGVFYGEIFGLHQLGEWIWGGHPPLRKGLSYGEWATGWLVVAVLAGWVHLTIGWALDFVDNYTLHGLTDAVLESGSWIAMLTGIWLWVFSTHLEGTKPELLFATFDGEPFAFGFAGFSPTVGFLGLGLLALGIALLIVGPVYELPEVAQPFAHTLSYTRLTAVLLSKAGMALVVNMLYFGAYQDEKGAYHYLIDHGPHYVETHEGAEMVFSGLYHTGLAGQIGGLLVLLIGHLVVLAIGVSAMIQAVRLEYVEFFGKFYEGSGKRFDPFGYDRDNTTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVV7</accession>
    <name>R4VVV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06965"/>
    <dbReference type="EnsemblBacteria" id="AGN01340">
        <property type="protein sequence ID" value="AGN01340"/>
        <property type="gene ID" value="L593_06965"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1423"/>
    <dbReference type="eggNOG" id="arCOG02079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367872_0_0_2"/>
    <dbReference type="OrthoDB" id="67963at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="350"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="461"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="757" mass="76664" checksum="C71561F0E98A1006" modified="2013-07-24" version="1">MDVLGRSAPIEVVAVTDRRRDGVALVLVGVLLAVALTTGPAAAAGVHANGTITDCGTIDQPGGYELAGNVTNSSDDYCLQVATSNVTIDGNGHTVDGVDDLTGYGVSAVGSSVSNVTVRNLTVTNFYHAGTVEKASDVTFRNLTATASRDHGVVIDGGSGVRVTDSAVDGSGSAGVFAVNTANLSLRNATVTDNAGRGVSLDAVRNVTIQDTLTANNSRWAMTATNGSTVSSATNYTLTGGQSVDFSAHDVSLRANETPPALPAWKHQLGPVLNATNESAGAWLELGYDGSSLLPGHDEGSTTLWRYEGNWSINGGSNAIDTVNDTVNASIDAAGSYALLADEEPIANATPASLDFGTVHMTDPATTRAVTVANDGQAPLTVVVVGATGENASAFYVPPLIGNLTLQPGENASFDVEFDPTTERGQLNATFVAAHDGSSEFANVSLTGRSVAPNVNVTTGPTVDFGEVHVGTPSRGRTIVVENNGSAPLDLPDATITGENATAFDFHTDGDPTPHLLAPGDQVAFEVELLPASLGTKSATLEIAHNVSNRATVTLTLRGTGADLRPPQIANLSAVDATDGDGIVTDGDAITIGANVSDGVTGVSDVSVNASAFGAGTVTLSNGSSGEFYDATVVVDAANASADGVHQLDVNASDAAGNANDTAAGSVTLDTTAPSVSITTPMEGYALNGSNLTVTGTVSDQFAGVQSVAFDDGTGWTDVGFDRGAGTWNATITNLSAGAHTYRVRATDDVSHVSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVX9</accession>
    <name>R4VVX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446259.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01365">
        <property type="protein sequence ID" value="AGN01365"/>
        <property type="gene ID" value="L593_07090"/>
    </dbReference>
    <dbReference type="GeneID" id="16182282"/>
    <dbReference type="KEGG" id="sali:L593_07090"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101251_0_0_2"/>
    <dbReference type="OrthoDB" id="72641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="213" mass="23456" checksum="2562603CF39970C2" modified="2013-07-24" version="1">MPHARLTIDVPETVWIGELSARHPDLVFEVLTAISGEDVGIALVRLGADDPLPVITEIQARDDVETVELLWKHDDEALLQIETTNPLPLVPIWRAGVPLRMPFDIQDGHATWEVTTSRGRLSTLQTALDDVGIGFTVEYVQAIEASQADRLLTDRQLEVLTTAVDAGYYRSPREATLGEVADLLGIATATCSDVLHRAEGHVVHWFVEEHVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVY1</accession>
    <name>R4VVY1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Taxis protein CheF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in taxis signal transduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445315.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02350"/>
    <dbReference type="EnsemblBacteria" id="AGN00421">
        <property type="protein sequence ID" value="AGN00421"/>
        <property type="gene ID" value="L593_02350"/>
    </dbReference>
    <dbReference type="GeneID" id="16180178"/>
    <dbReference type="KEGG" id="sali:L593_02350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.477"/>
    <dbReference type="eggNOG" id="arCOG02394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968406_0_0_2"/>
    <dbReference type="OrthoDB" id="38718at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007381">
        <property type="entry name" value="CheF1/F2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42201">
        <property type="entry name" value="PTHR42201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04283">
        <property type="entry name" value="CheF-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026802">
        <property type="entry name" value="UCP026802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="294" mass="32605" checksum="B0F27145EFF82E4B" modified="2013-07-24" version="1">MSRTERILLDGAGRFLQVVKDGRTLDDVGWIEGRVLLSSERLVLAGNEGTRTIPLESVDEFGGRYDVNQSIARVSHYTSVRVGEQVLLVTTAANPEELEENLYSALLDHERVFARHPAVEGGVLQGTEWHPAQLKTEPDLLNVALTNGTLAEIELDDISELTTGEQTLSVGDLDAEERRVLKVEHSKPSGTSVQTYLSGDERQIRFLESLLKEGEARSAIGVDLNVDEKQVLMALHSGVSPFEIPDFVGMEVDRVEEIYERLVELDALNEVRMRREVELTARGRKIAGGAMDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW31</accession>
    <name>R4VW31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-archaeol synthase</fullName>
            <ecNumber evidence="6">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carS</name>
        <name evidence="7" type="ORF">L593_07400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446319.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="SMR" id="R4VW31"/>
    <dbReference type="STRING" id="1333523.L593_07400"/>
    <dbReference type="EnsemblBacteria" id="AGN01425">
        <property type="protein sequence ID" value="AGN01425"/>
        <property type="gene ID" value="L593_07400"/>
    </dbReference>
    <dbReference type="GeneID" id="16182115"/>
    <dbReference type="KEGG" id="sali:L593_07400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1512"/>
    <dbReference type="eggNOG" id="arCOG04106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105710_0_0_2"/>
    <dbReference type="OrthoDB" id="124973at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="18414" checksum="FADF6064A40566CC" modified="2013-07-24" version="1">MVLEVVAIAVWAMLPAYVPNNVAVLAGGGRPIDGGRTWGGKRVLGDGKTWRGTAFGIAAGLALALALDAIAGDAGSTLGVDLPGFPITAALALPAGAMLGDVGASFLKRRTGRERGAAFPGVDQLDFVVGALGLTALAARDWFGDVFEPPVLLAVLVLTPVLHVGTNVIAYQLGFKDEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW67</accession>
    <name>R4VW67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ORF">L593_07600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446359.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07600"/>
    <dbReference type="EnsemblBacteria" id="AGN01465">
        <property type="protein sequence ID" value="AGN01465"/>
        <property type="gene ID" value="L593_07600"/>
    </dbReference>
    <dbReference type="GeneID" id="16182162"/>
    <dbReference type="KEGG" id="sali:L593_07600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1557"/>
    <dbReference type="eggNOG" id="arCOG04748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_2"/>
    <dbReference type="OrthoDB" id="4923at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="443"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AGN01465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="698" mass="78932" checksum="C6E8D08A3A82788C" modified="2013-07-24" version="1">MSDSGPLSADRPDAESPFRVDAPFEPAGDQPAAIRQLVEGYETHGYDDQTLLGVTGSGKTNTVSWAIEELQQPTLVIAHNKTLAAQLYEEFRELFPDNAVEYFVSYYDYYQPEAYVEQTDTYIDKDASVNDEIDKLRHSATRSLLTRDDVIVVASVSAIYGLGDPANYRDMSLQVEEGQQIDREDLLARLVDLNYDRNDVDFTQGTFRVRGDTVEIFPMYDRYAMRVELWGDEIDRIVRVDPLDGEVVGEESVALLHPAEHYSIPKTQLEQAIEEIESDLQDRISYFERQGNHVAAQRIEERTTFDLEMMREAGYCSGIENYSVYLSDRESGDAPNCLLDYFPDDFLTVIDESHRTVPQIKGQYEGDRSRKQSLVENGFRLPTSFDNRPLTFEEFEEKTGRTLYVSATPSDYEREHSGQVVEQIVRPTHLVDPAIEVSPAEGQVDDLIDRIDQRVNAEGTTTDEAGDATGERVLVTTLTKRMAEDLTEYLEGAGYDVAYMHDETDTLERHELIRSLRLGEIDVLIGINLLREGLDIPEVSLVAILDADQEGFLRSETTLVQTMGRAARNVNGEVVLYADEVTDSMDRAIDETRRRREIQREFNEEHGFEPTTIDKPIGETNLPGAETDTSSVAGVGPEDMDEAERHVEELERRMAEAAENLEFELAADIRDRIREIREDFELDASAGEGIAPEPDAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWM3</accession>
    <name>R4VWM3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein PrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446534.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08475"/>
    <dbReference type="EnsemblBacteria" id="AGN01640">
        <property type="protein sequence ID" value="AGN01640"/>
        <property type="gene ID" value="L593_08475"/>
    </dbReference>
    <dbReference type="GeneID" id="16182428"/>
    <dbReference type="KEGG" id="sali:L593_08475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1736"/>
    <dbReference type="eggNOG" id="arCOG00313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093041_0_0_2"/>
    <dbReference type="OrthoDB" id="80199at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="24550" checksum="72343C09E9A04C39" modified="2013-07-24" version="1">MNRRTVLSRLGGAATLGIAGCLGGDGGGGDGNVVLDEPDRQFESADVPYPAWGERVPDVTLPAIPGESPVSVRELDEPALLTYFYSSCQTVCPVLISTLRNVQAHAQTNGYADEVQFLPITFDPERDTAERLQDYADQMNVDLSAGNWQFLRPESPDRARTVVDEQFGVVFQRTHPEDMDMYMFTHGAMTTLVNADGYVERAYRSQSPDQDRIVDDLATVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX12</accession>
    <name>R4VX12_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="6" type="ORF">L593_04250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445695.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04250"/>
    <dbReference type="EnsemblBacteria" id="AGN00801">
        <property type="protein sequence ID" value="AGN00801"/>
        <property type="gene ID" value="L593_04250"/>
    </dbReference>
    <dbReference type="GeneID" id="16180872"/>
    <dbReference type="KEGG" id="sali:L593_04250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.865"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610619_0_0_2"/>
    <dbReference type="OrthoDB" id="25601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="478" mass="50200" checksum="E82FFF602F97BDB3" modified="2013-07-24" version="1">MIGIVESRADEASEHVCEHLRRLGSFEARTDPDRANAEGGGTYHRSDAFELRSFDALHLELDRVADAFDDPDLIVFASRHSGDTGPLLSAHPTGNFGDAEYGGADRSLARAPPNALAAVIEALAEHAPEAYDVSLECTHHGPTDVGAPSMFVELGSGPEQWADPAGAEAVARAILDVAGVAADAPLENDIRRHVVGFGGNHYAPRFTRIARETDWAVGHVVADWSLDELGSPAANADVVEQAFAQSAADCAVVEGSHPALESAIADLDFRIVGETWLRETAGVPLALVETAEDRLVGVEDGLRFGDPVRERGGERATASGYGAGSELTGSGEPASTRLAVVDLPTDLLDVAAGIDREATMAAIDEACVAYETTEAGNRPGDRALVPGDGLPDHDVPQRLLGSLAAILRERFDSITVEADRIVAEETAFDPALAIEAGVPEGPAFGKLSAGEPVAVDGETVAPEDVHERRRVEFPLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXN0</accession>
    <name>R4VXN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446909.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10350"/>
    <dbReference type="EnsemblBacteria" id="AGN02015">
        <property type="protein sequence ID" value="AGN02015"/>
        <property type="gene ID" value="L593_10350"/>
    </dbReference>
    <dbReference type="GeneID" id="16181532"/>
    <dbReference type="KEGG" id="sali:L593_10350"/>
    <dbReference type="eggNOG" id="arCOG06423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2968402_0_0_2"/>
    <dbReference type="OrthoDB" id="121385at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="59" mass="6484" checksum="B42EC7487B3B3D18" modified="2013-07-24" version="1">MASAPGSSGDDMFDEFLASRGHEQTTWETEYNKKRCPECSGIHDVDATNCTVCGWQPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXN1</accession>
    <name>R4VXN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445915.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05360"/>
    <dbReference type="EnsemblBacteria" id="AGN01021">
        <property type="protein sequence ID" value="AGN01021"/>
        <property type="gene ID" value="L593_05360"/>
    </dbReference>
    <dbReference type="GeneID" id="16180624"/>
    <dbReference type="KEGG" id="sali:L593_05360"/>
    <dbReference type="eggNOG" id="arCOG01084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142229_2_0_2"/>
    <dbReference type="OrthoDB" id="116125at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="10610" checksum="AB61D30C00170D30" modified="2013-07-24" version="1">MDDPQQRVAAFVADKDLSAPPAYRLLDLVSETGELAKEANESTGYGTDPDAIDLSADELGDVYFSLLALAEAADVDAEAALSGALAKYERRLEEGDTAGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXT2</accession>
    <name>R4VXT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446969.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10650"/>
    <dbReference type="EnsemblBacteria" id="AGN02075">
        <property type="protein sequence ID" value="AGN02075"/>
        <property type="gene ID" value="L593_10650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181398"/>
    <dbReference type="KEGG" id="sali:L593_10650"/>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116577_2_0_2"/>
    <dbReference type="OrthoDB" id="104837at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="167" mass="18054" checksum="F8D951C1B094BAD1" modified="2013-07-24" version="1">MHDEPPTPTELDRIRRVANFQFGHGGAAALFPEVGPRGTEAVGDVTITRTASGRVEQCFDDGDRLFTKETNGRFVLSVEGGRRIVEGLDAPRHRVEVGEESVEFVRDGRNAFAKFVRSVDPDLRPGDEAVVVYDGDVLGVGRAELSPDAMADFDTGVAVFVRHGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU0</accession>
    <name>R4VXU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446979.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10700"/>
    <dbReference type="EnsemblBacteria" id="AGN02085">
        <property type="protein sequence ID" value="AGN02085"/>
        <property type="gene ID" value="L593_10700"/>
    </dbReference>
    <dbReference type="GeneID" id="16182545"/>
    <dbReference type="KEGG" id="sali:L593_10700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2206"/>
    <dbReference type="eggNOG" id="arCOG04639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766212_0_0_2"/>
    <dbReference type="OrthoDB" id="127489at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="7848" checksum="CFBA21B54BF7F873" modified="2013-07-24" version="1">MSFEEDDVVVLHDEHSDFDGEQGTVTQIVETMFGDANYTVSFEDGQETGVPEDNLEAADEAEDDESDADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYG8</accession>
    <name>R4VYG8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msrB</name>
        <name evidence="5" type="ORF">L593_11810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447199.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11810"/>
    <dbReference type="EnsemblBacteria" id="AGN02305">
        <property type="protein sequence ID" value="AGN02305"/>
        <property type="gene ID" value="L593_11810"/>
    </dbReference>
    <dbReference type="GeneID" id="16180727"/>
    <dbReference type="KEGG" id="sali:L593_11810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2431"/>
    <dbReference type="eggNOG" id="arCOG02815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_2"/>
    <dbReference type="OrthoDB" id="88729at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="15131" checksum="D4B8609DE6B81DBA" modified="2013-07-24" version="1">MSETATDDLPETDAEWRERLDEDEYHVLRNSGTEPAGSGEYDDHWEDGQYRCAGCGVVLFDSDAKFEHGCGWPSFFQPAAEDRVEYEEDTSHGMVRTEVLCATCDGHLGHVFDDGPEPTGKRYCINSVALDFEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYL4</accession>
    <name>R4VYL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447244.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02350">
        <property type="protein sequence ID" value="AGN02350"/>
        <property type="gene ID" value="L593_12035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180262"/>
    <dbReference type="KEGG" id="sali:L593_12035"/>
    <dbReference type="eggNOG" id="arCOG06286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949404_0_0_2"/>
    <dbReference type="OrthoDB" id="142350at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="7020" checksum="4F7C29391F55C0E3" modified="2013-07-24" version="1">MRAEDDIRRRLEDLEARYDDNDPPSSPTADELEVELLRAIAELEWVLDERSEPQELPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYR2</accession>
    <name>R4VYR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447294.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02400">
        <property type="protein sequence ID" value="AGN02400"/>
        <property type="gene ID" value="L593_12305"/>
    </dbReference>
    <dbReference type="GeneID" id="16179854"/>
    <dbReference type="KEGG" id="sali:L593_12305"/>
    <dbReference type="eggNOG" id="arCOG03070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_8_2_2"/>
    <dbReference type="OrthoDB" id="118421at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14434" checksum="7C1B10EA02692C79" modified="2013-07-24" version="1">MVFESGLEGDLLLLARLLFGAVLAFQGMNHFLNADQMAGYAGMKGVPLPGVAVVGTGLILLGGGLGIVLGVFPTIAAGALAVFFLVTTPLMHDFWAVDDEQAQDEMIQFLKNAELFGASVLFLAISGTEWAYSLGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYV2</accession>
    <name>R4VYV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01421">
        <property type="protein sequence ID" value="AGN01421"/>
        <property type="gene ID" value="L593_07380"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1507"/>
    <dbReference type="eggNOG" id="arCOG04755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="244" mass="26267" checksum="246BCEFF7B1877C8" modified="2013-07-24" version="1">MATWKRDFASGLVVLVPIIVTIWVVLWVYGIIANAPFLAAVDASLLESFGIENVPVELVRVVVTLVVFTLLVLGVGYLMRTAVGNLFESALDRLVNQVPGLRVVYNASKMAAETALTGTQSLQTPVKVEPWDGMRLTAFKTGKQTPDGRELLFMPTAPNITTGFVVEVAPEDITETDEGVETALTRLLSAGFGDEEEASSRVLPSGVTEEDVSEALDDADAEEEIGIERSAERRAGEVDATPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ68</accession>
    <name>R4VZ68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13130"/>
    <dbReference type="EnsemblBacteria" id="AGN02565">
        <property type="protein sequence ID" value="AGN02565"/>
        <property type="gene ID" value="L593_13130"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13130"/>
    <dbReference type="HOGENOM" id="CLU_985599_0_0_2"/>
    <dbReference type="OrthoDB" id="23493at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="30768" checksum="E58EC3CDB667DA6D" modified="2013-07-24" version="1">MLVDPNLQSVVDQPDWERPYARASMEYVDCVALRERDAPVADWATTTGGAYRFLGVTDPESLGSLRQTAITRYETSFAQSQLLAGTGAYAAGPVDERGLDSEYTADDPDTRIEGHGVYSFETHGKLGVSDTGLAFARPWNYIDEELEEATDAAYEQFATGLLRRSIARAKEGPTPPDWLAAALERLGSYQYATFDLRSAAGPNPDRIFARSFDVQGTETSLQVLMATPKASNFEQVWDPSGVERQFRQWPDASPSLDVGDRIGVATATVPTEDTALANEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZV0</accession>
    <name>R4VZV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447674.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14205"/>
    <dbReference type="EnsemblBacteria" id="AGN02780">
        <property type="protein sequence ID" value="AGN02780"/>
        <property type="gene ID" value="L593_14205"/>
    </dbReference>
    <dbReference type="GeneID" id="16181133"/>
    <dbReference type="KEGG" id="sali:L593_14205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2906"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="373" mass="40241" checksum="C227DCA9DEF5DABD" modified="2013-07-24" version="1">MTAFSERVESVSISGIRKVFEAAGEDAINLGLGQPDFPTPAHARDAACEAIQDGLADGYTSNKGTESLREAIAHRYDVDWDIDVDPADVIATAGGSEALHIALEAHVDPGEEVLFPDPGFVSYDALTKIAGGDPVPLPLREDLTLDPATVEEAITDDTAVFVVNSPANPTGAVQSEADMREFARIADEHDVLCLSDEVYEHIVFDGEHHSPIQYAESDNVVVVSACSKTYSMTGWRLGWVTGSERRIERMLRVHQYGQACASAPSQYAAEAALTGPREPVEEMVTAFEERRDLVLDELTDMGLEVPTPQGAFYAMPSVPEGWVDEVIDRGVVVVPGDAFGERGAGYARISYATGLEELEDALAIMRDATRAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW1</accession>
    <name>R4VZW1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ORF">L593_09055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446650.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09055"/>
    <dbReference type="EnsemblBacteria" id="AGN01756">
        <property type="protein sequence ID" value="AGN01756"/>
        <property type="gene ID" value="L593_09055"/>
    </dbReference>
    <dbReference type="GeneID" id="16182785"/>
    <dbReference type="KEGG" id="sali:L593_09055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1857"/>
    <dbReference type="eggNOG" id="arCOG02268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_2"/>
    <dbReference type="OrthoDB" id="20185at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="417" mass="44567" checksum="DB89479DD71A0D22" modified="2013-07-24" version="1">MTDSSPPIRRLADWDHDELAGLADEYGTPLYVTDLDRVAANYDRIDDAFEGIECMYAAKANTGQAVMRRLLEEGANIECAAAGELHRAVEAGAEPNTLQYTATNPPAKDLDWVVDFWETDAPELTVTIGATDTLDRLEARGYDGRIAIRVNPGIGAGHHEKVATGKDAKFGIPHGDVPEAAADAAERFDLVGLHAHVGSGMLTEEDLHAHRRALERVADAATVVESEQGSGTLDFVDVGGGFGVPYREDEEPLDLDAVAATITETFADVDARLKVEPGRYVVADASLVLTAVNTIKEAPEATVVGVDASLATMIRPAMFDSYHPIRNVSAPQRAAIPASVGGPLCTSADVFCTGRPIAEPRRGDLLAIGNTGAYGIELANQFHSQPKPAEVGLEGGEASVLRGREDYDDLLHHERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZZ0</accession>
    <name>R4VZZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09230"/>
    <dbReference type="EnsemblBacteria" id="AGN01791">
        <property type="protein sequence ID" value="AGN01791"/>
        <property type="gene ID" value="L593_09230"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09230"/>
    <dbReference type="eggNOG" id="arCOG08125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3020861_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="56" mass="6275" checksum="CB31BFEE3DC1E518" modified="2013-07-24" version="1">MKSVRKGLRDSDLEKDNYGRLACTACDEELKSENDPDEVGTVRVCPSCGAKWKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W013</accession>
    <name>R4W013_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenite-activated ATPase ArsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446710.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09355"/>
    <dbReference type="EnsemblBacteria" id="AGN01816">
        <property type="protein sequence ID" value="AGN01816"/>
        <property type="gene ID" value="L593_09355"/>
    </dbReference>
    <dbReference type="GeneID" id="16182687"/>
    <dbReference type="KEGG" id="sali:L593_09355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1923"/>
    <dbReference type="eggNOG" id="arCOG02849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_2_1_2"/>
    <dbReference type="OrthoDB" id="84406at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="45124" checksum="88105991B0207AA1" modified="2013-07-24" version="1">MKDIDVEPVDDVDADDDGPGDPHATDGPDDATDEEGGPASPGDGSTDADAPADHSALDADRLPPVASDTPEFVLYGGKGGVGKTTMAAATGLASAAAGTRTLVVSTDPAHSLSDTYETAIGAEPTRLRGDLPLYAAEIDPDAAMEEGMSMFGDQAGTGGAGGPTAGGAEGAGGPGGADASGGGPFDPDASGGQGPAGGMGGLGAMMGGDSPLQSMLGGTMPGSDEAVAMQQLVEFMDDDRFDRVVVDTAPTGHTLRLLELPELMDTMVGRILSMREKLSGLFDGLSGMFGGEDADAEAGTQSLRELSDRIERLRETLTDPALTDFRIVMVPEELSVIESERLLRQLDDFSIPVETVVVNKVMEDLADVTGEVPADDVVTPNLEDCEFCQRRWDVQQRALTRAQEVFRGRSIERVPLLAEEVRGEQSLRVVAACLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W015</accession>
    <name>R4W015_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447744.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14555"/>
    <dbReference type="EnsemblBacteria" id="AGN02850">
        <property type="protein sequence ID" value="AGN02850"/>
        <property type="gene ID" value="L593_14555"/>
    </dbReference>
    <dbReference type="GeneID" id="58789383"/>
    <dbReference type="KEGG" id="sali:L593_14555"/>
    <dbReference type="eggNOG" id="arCOG14530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159096_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11344" checksum="2625B2978519A22C" modified="2013-07-24" version="1">MRVPVPKNKLVAFTLIGALLTAGVAGALALPGGGLAQAGEQPDSPGSTASEASQQAASDAPTPNQDFTPAVQTQSGYEEEEHEEYEEDDEEEYEEEHEDEEHEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0J6</accession>
    <name>R4W0J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system, phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446940.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10505"/>
    <dbReference type="EnsemblBacteria" id="AGN02046">
        <property type="protein sequence ID" value="AGN02046"/>
        <property type="gene ID" value="L593_10505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182421"/>
    <dbReference type="KEGG" id="sali:L593_10505"/>
    <dbReference type="eggNOG" id="arCOG04543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_2"/>
    <dbReference type="OrthoDB" id="124925at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9574" checksum="2F667F66AFE6105F" modified="2013-07-24" version="1">MHRVVTVRQEAGLHARPAAVFVETANEYDSEITVGPAEGEDGEAASSAVDAGSMLAVTGLGVEQGDRVRITAEGPDAEAALDELAGLLTQKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0K7</accession>
    <name>R4W0K7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl11p</name>
        <name evidence="4" type="synonym">rpl11</name>
        <name evidence="9" type="ORF">L593_10605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446960.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10605"/>
    <dbReference type="EnsemblBacteria" id="AGN02066">
        <property type="protein sequence ID" value="AGN02066"/>
        <property type="gene ID" value="L593_10605"/>
    </dbReference>
    <dbReference type="GeneID" id="16179927"/>
    <dbReference type="KEGG" id="sali:L593_10605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2187"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OrthoDB" id="98187at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="162" mass="17113" checksum="AD4100EA00D5E920" modified="2013-07-24" version="1">MAGTIDVLVPGGQANPGPPLGPELGPTPVDVQAVVQEINDQTEAFDGTEVPVTVEYEDDGSFEIEVGVPPTAELIKDEAGFDTGSGTPQSEFVADISVDQVKQIAQQKLTDLLAYDEKNAAKEVVGTCTSLGVTIEGENPREFKKKIDEGEYDDVFAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0R9</accession>
    <name>R4W0R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11030"/>
    <dbReference type="EnsemblBacteria" id="AGN02151">
        <property type="protein sequence ID" value="AGN02151"/>
        <property type="gene ID" value="L593_11030"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2274"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="373" mass="39158" checksum="A6D45CF61DC39E01" modified="2013-07-24" version="1">MTTVQEKDTTGIETAEATTDADSTATPAETPMIQARNLTKRYGDLTAVDGVDITVERGSIHGFVGPNGAGKSTTMQMLTGLVSPTAGEVRIGGDPAGSYAATAKIGYAPQEPAFYESMTGRNYLVYMGRVAGMGRNEASERADELLEWLDLADAADQTIGGYSGGMARKLGLAQAMIHDPELLILDEPTATLDPEGRASIIDSLQDLTEEGMTVFVSSHVLAELERFVDTVTILAEGQVARSGPLEAIRSAVSTETYVVDTTDNDRLATLLADHPTVERVERRDGGRVAAVPAEPEDFTIELQGMIGDAELGLRSMEREDGLEEAVLHLIEETQNGTAAGGVTGEATRTAAEGGADAPEAAPASDDPGREGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Z2</accession>
    <name>R4W0Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11305"/>
    <dbReference type="EnsemblBacteria" id="AGN02206">
        <property type="protein sequence ID" value="AGN02206"/>
        <property type="gene ID" value="L593_11305"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2332"/>
    <dbReference type="eggNOG" id="arCOG02877">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654918_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="419" mass="46528" checksum="AD265D4E4F460CF6" modified="2013-07-24" version="1">MSGESAERSDADGQTVEDEAGPAPDANEAWPPSEVRAADEDVEVQRESAGSAPDGVGAARIDRPGVQEPPRPPNEVTSRRDARPLTGEPSPVDAPPASEPSGSAIQTFTPGTNQDWTAGVIADGDPQVGDDLLPDHSFALCLTHDVDRPYKLAQAFFYALRDRDPTQLASLLPGRQPNWTFDTILQIEARHDVRSAFYFLDEQRLFRDRPMREWLDLDAWRLYADRYDLDDPAIVELLHRLDRGGWEVGLHGSYESYDDRERLRAEKERLERVLGTPIRGGRQHYLNRTLPETWEHHAAIGQDYDATIGSASEIGFGYGDTIGRPFDDSFVAFPLTMMDVAMPDPGTDPAAAWSAADRVLEAAAERGAITTVLWHPRVFNESDWPGHTDLYRHLIERAQSLGGWVGSPAELYDELDHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1U8</accession>
    <name>R4W1U8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ORF">L593_13485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447530.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13485"/>
    <dbReference type="EnsemblBacteria" id="AGN02636">
        <property type="protein sequence ID" value="AGN02636"/>
        <property type="gene ID" value="L593_13485"/>
    </dbReference>
    <dbReference type="GeneID" id="16180654"/>
    <dbReference type="KEGG" id="sali:L593_13485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2758"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_2"/>
    <dbReference type="OrthoDB" id="59062at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02008">
        <property type="entry name" value="Tyr_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023684">
        <property type="entry name" value="Tyr-tRNA-ligase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="36681" checksum="59DD5302B5B6BBD9" modified="2013-07-24" version="1">MEAYELLSRNAVEVVTDEEARELAADPEGKRAYVGYEPSGALHLGHLLTANKLIDLQKLGMEVVVLLADVHAYLNGKGTFEELHETAEAMQAQFLAYGLDPDQTEFVYGSDFQLEEDYVLDVHQLSVETSLNRAQRAMAEIQSGETASVAHVVYPIMQALDIEYLDLDLAIGGIDQRKVHMLHREGMPEMGYDVRPCLHTPIIADLETGVGKMSASEGIDITMEDSTEDLEEKINAAYCPPTRDPEPTDEGEDREHPVLQLFQYHVFPRFESVTVERPDEYGGNVTYDSYEALATALDTGELHPADAKSALASALDELIAPGREKLRELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W201</accession>
    <name>R4W201_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447585.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13760"/>
    <dbReference type="EnsemblBacteria" id="AGN02691">
        <property type="protein sequence ID" value="AGN02691"/>
        <property type="gene ID" value="L593_13760"/>
    </dbReference>
    <dbReference type="GeneID" id="16180827"/>
    <dbReference type="KEGG" id="sali:L593_13760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2814"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_1_0_2"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="447" mass="50107" checksum="3E95F6CDFA4076E6" modified="2013-07-24" version="1">MGLFDRLSGDDRPRVAFIGIDGVPWSLVADNPGEFPNLTALAEDGAGGAIESIVPPESSACWPALTTGENPGETGVYGFQDREIDSYDTYVPMGNDVQATRVWDRVTEDDRKATVLNVPVTFPPQRNVQRMVSGFLSPGVDKAAHPEELRSYLDSIDYRIDVNAKLGHQDDRTEFVADAHETLDARFEAFDHYIQQDDWDLFFGVFMTTDRVNHFLFKDYVEDGEFAEEFMTFYRQLDSYLGQLRNELGDDVTLVIASDHGFQELNWEVNCNQWLRDEGWLSFEDDEHENLGDITDESRAYSLIPGRFYLNLEGREPRGSVAQEDYEAVRAELKDDLESLEGPDGNPVAMRVVEGEDVFEGAHDAIAPDLVVIPNTGFDLKSGFKGGKDVFTNGPRNGMHNFEDATLFVDDPDAQIVDANLYDVAPTILDLMEVDYEQSEFDGASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W292</accession>
    <name>R4W292_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">L593_14160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14160"/>
    <dbReference type="EnsemblBacteria" id="AGN02771">
        <property type="protein sequence ID" value="AGN02771"/>
        <property type="gene ID" value="L593_14160"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2897"/>
    <dbReference type="eggNOG" id="arCOG00089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="27524" checksum="FCE344B93BA0E3B5" modified="2013-07-24" version="1">MAITVIPIRPRAATVASKENHLPANVESVDMSQEQVAGDAVDAGEDPLAEIAVVDYGLGNLRSVTRGLERAGAAVEITDDRDEIRAADGIVLPGVGAFREGVENAGPFRDALLEAAEDGQPLFGICLGMQMLLTDSEEAERAGQGDVTGLDLIPGTNRRFDQGQKVPHMGWNELHVEQEHPLVEGVDGDYAYFVHSYYAVPEDEAATVATTDYETRFASVVANEAGNVFGTQFHPEKSGETGLRILRNFVELCAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2I3</accession>
    <name>R4W2I3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447795.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14835"/>
    <dbReference type="EnsemblBacteria" id="AGN02901">
        <property type="protein sequence ID" value="AGN02901"/>
        <property type="gene ID" value="L593_14835"/>
    </dbReference>
    <dbReference type="GeneID" id="16181520"/>
    <dbReference type="KEGG" id="sali:L593_14835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3030"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_1_1_2"/>
    <dbReference type="OrthoDB" id="82715at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="24302" checksum="1EAE5232B154AFCF" modified="2013-07-24" version="1">MRVGVISDVHANLPALEAVLRDIGHVDAILNAGDVVGYNPWPAACVEEMRTREVPTVRGNHDRAVVEQTTFRFNEMAAAGVDYASRQLDEAQFEWLASLPEALSRFDGRVRVVHGHPDDPDRYTYPEDFAASMLGEEDVLVLGHTHVQHVEQFDDGIVLNPGSVGQPRDRDPAAAYAILDLDAMAVELRRVEYDVERVIEAVNDAGLPERIGERLRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2M4</accession>
    <name>R4W2M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_15110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.3086"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="88"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="427" mass="44604" checksum="3F462E0A9329512B" modified="2013-07-24" version="1">MDGSATSAGTDDESLATGQRSLKDRSIEYPLWPPQTGGCPETSDEAVQYPVEVTYEYEAVPDGLFEGPIEHGIDQWQPLLPPLAEGTSLGEGNTPLLAAPDVADWAGAGAGTEVYVKDESRNPTWSQKDRLARLTVSASVGVDAPGIVVSSSGNHGAATAAYGARAGLSVVVFTSPDTPAAVQQFVGAYDTAILQIPDWHARQEAVDRLAATAGYHPVSSRTAVPTGHPWGPEGYKTIAYELFLQLDRRVPGTVFVPTAHAEVLYGVWKGFRELESLGVTAETPRMIACEPAARAPHVAALESEAALPSVAPGDTDAHSIQATQATYHGVTAIDESDGDATGVTDDAIAEAQALLAARGCWQEFSGAAGVAGLREAAADFDGSLDGPIVCLATSSGFKDGETLDAPTVDGSWESIRNALRTEYGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2S5</accession>
    <name>R4W2S5_9EURY</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00122">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="44" mass="4785" checksum="36D946E29AC545F8" modified="2013-07-24" version="1">MHGIDPYESTDPTFECPSCGARSDDRGECDSCSTTMLNISVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3C8</accession>
    <name>R4W3C8_9EURY</name>
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        <submittedName>
            <fullName evidence="4">TrkA-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02505"/>
    <dbReference type="EnsemblBacteria" id="AGN00452">
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    </dbReference>
    <dbReference type="GeneID" id="16180244"/>
    <dbReference type="KEGG" id="sali:L593_02505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.508"/>
    <dbReference type="eggNOG" id="arCOG07570">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038780_0_0_2"/>
    <dbReference type="OrthoDB" id="35453at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCK_C"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="43030" checksum="AF5ADBD27DF92DA0" modified="2013-07-24" version="1">MIHESIDLVPAVAKVLAMAIGAASVAAVASFVYRWYSRSSIPEGVAVLLGVSVVALALNTTATLQDSVAADELISGTAAGYTLVAFAAGAIAADAGRRFGERLAVDVPGVDSVRTMESDVGSLVRAAGRVLRVHVPESIDDIDGYEPVPAGVKADLAGTTFLFPRRMTVAELTDRFVERLTRDYEIGHVDVEFADDGTIEYLAVGRRLAGIGQTLAPGTVAVAIHADPAFSATPGDRVQIWRPTAGSATDSGAESSDDGAAPELVTTGELRAAIGDVATIALDEGDVDRLADDVRYRIATLPAAVQADREFASLLRSADETMGSVTIEAGSDLDGNRVETVELTVAALEDDADVTAIPAGDRLLRPGETIYVVGRPDGIRRLEARASGERTDESSRTSSPSLEPRTPDADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3I2</accession>
    <name>R4W3I2_9EURY</name>
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        </submittedName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00547.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02980"/>
    <dbReference type="EnsemblBacteria" id="AGN00547">
        <property type="protein sequence ID" value="AGN00547"/>
        <property type="gene ID" value="L593_02980"/>
    </dbReference>
    <dbReference type="GeneID" id="16180427"/>
    <dbReference type="KEGG" id="sali:L593_02980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.604"/>
    <dbReference type="eggNOG" id="arCOG01972">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12456" checksum="C30732095C047DC0" modified="2013-07-24" version="1">MTTDTATNQSAETNDTPVPVNGQSDLEELVGDGGVVLADFYADWCGPCQMIAPVVEELAAETEATVAKVDVDANQPLAAAYGVRGVPTLVLFAGGEQVEEIVGVQSKDRLASLIDRYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3M5</accession>
    <name>R4W3M5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_03355</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00622">
        <property type="protein sequence ID" value="AGN00622"/>
        <property type="gene ID" value="L593_03355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03355"/>
    <dbReference type="HOGENOM" id="CLU_2911691_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6611" checksum="C91B40578EAF3632" modified="2013-07-24" version="1">MNRQYLRYSGVCAALTVLLIFLYYTALDSYQGEIGAILPPAVTAGVALLFLLLGLGKMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3N1</accession>
    <name>R4W3N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03405"/>
    <dbReference type="EnsemblBacteria" id="AGN00632">
        <property type="protein sequence ID" value="AGN00632"/>
        <property type="gene ID" value="L593_03405"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.689"/>
    <dbReference type="eggNOG" id="arCOG01385">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="304" mass="33131" checksum="CFA8B67F582B6C6F" modified="2013-07-24" version="1">MADGIVVELLAFGVVGVAAVVAVGVVALVVAVLGHDRGSARHPFERRGSAQRPTDVGEAPVIVDATNPQDRSVQLPSGRTGESMGAAPTVSIVIPARNEADYLPDCLDSVAALDTEYDYETIVVDGDSDDRTPKIAREYDVRLVEGPGESIGGGRALGAEHAHGQWLSFVDADTVLHPDFLDEMLAFVEAEDLDAATSRCRMDGLRPKLMQATINRVFPRLRRPILPGFNFFIGREVYEAAGGFPEVPNEDTAFSRHLAREYDTAYHPDVLVETSGRRIHRWGLTGTLVHYLRLDVGRLMAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3X8</accession>
    <name>R4W3X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445681.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04180"/>
    <dbReference type="EnsemblBacteria" id="AGN00787">
        <property type="protein sequence ID" value="AGN00787"/>
        <property type="gene ID" value="L593_04180"/>
    </dbReference>
    <dbReference type="GeneID" id="16180858"/>
    <dbReference type="KEGG" id="sali:L593_04180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.850"/>
    <dbReference type="eggNOG" id="arCOG04712">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_0_2"/>
    <dbReference type="OrthoDB" id="35759at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="38011" checksum="E1F59EB56D28B886" modified="2013-07-24" version="1">MNMLVDGEWTTDAGEYTDETGAFQRQSTTFRDRVEDAPDADHPVEPGRYHLYVSYACPWAHRTLLARSLKGLEDAISVDVVDPFRAEDGWQFTPAKDGCTPDTVNGTEYLREVYVEADPEATCRVTVPVLWDKQEDTIVNNESKEILRMLDVEFDSIATRDVDLYPEGYRDDVDRIIEEIYDPINDGVYRTGFANSQQAYDEAVHELFDALDHWNAVLADQRYLAGDRLTEADLCMFTTLVRFDRVYHTHFMCNHRLISEYDNLWPYLRDLYQTPGVAETVEMNHIEEHYYTTHPDVSPKRIVPMGPDLDFAAPHDRDDLPGGPPEALATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W475</accession>
    <name>R4W475_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445851.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05040"/>
    <dbReference type="EnsemblBacteria" id="AGN00957">
        <property type="protein sequence ID" value="AGN00957"/>
        <property type="gene ID" value="L593_05040"/>
    </dbReference>
    <dbReference type="GeneID" id="16180996"/>
    <dbReference type="KEGG" id="sali:L593_05040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1027"/>
    <dbReference type="eggNOG" id="arCOG01026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061764_0_0_2"/>
    <dbReference type="OrthoDB" id="47243at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="35285" checksum="8F9EEFC4FED70F53" modified="2013-07-24" version="1">MPTVSAGARLHVGFCNLSLAHERLYGGIGVALDEPRVSVTAEPADAINAESADTGDPDDLAAEYAALATELLDVPGAHVTVEDRLPRHVGLGSGTQLALTIYAAIARAYDEPVDVREAAPDLGRGGRSGVGVAAFQRGGFVVDGGHPTARFTTERPPRGEWTVPPIVARHELPEDWRFVLAMPAVAGEDGQTAECQGTEPNRGRHGEDEDAAMRTVVEQATPAVADQVSAVLTRKLLPAAAQGDRAAFGDAVAEIERLNGSWYADAQGGVFRPPAGAIVESMQASDAIDAAGQSSWGPTVYGLSSAEHAAAARDAAAAALDAAGCDGTVRVVSPTNEGATVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4A3</accession>
    <name>R4W4A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator HTH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445901.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05290"/>
    <dbReference type="EnsemblBacteria" id="AGN01007">
        <property type="protein sequence ID" value="AGN01007"/>
        <property type="gene ID" value="L593_05290"/>
    </dbReference>
    <dbReference type="GeneID" id="16181304"/>
    <dbReference type="KEGG" id="sali:L593_05290"/>
    <dbReference type="eggNOG" id="arCOG02279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1163772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="25046" checksum="69A73CE8782F0D63" modified="2013-07-24" version="1">MSRGTESHDGRVVEVEFAVTAPAYPFVSIAREEDCRMVLEKQLPRGDGLQAEYFSVHDAPTAGVLDTADCDACHSANVLADGEGRCLVEFVVGEGCPARYLAERGAVPTTVEGTPDGGTIVAEIMPRHDPGEIVTAFERDHAVELVAKRARDRPTPLLSEGELQASVLDRLTDRQREVLHAAFEAGYYERPRRKTGEEIAEELDISPTTFQQHVRAAERKLVTFLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4H6</accession>
    <name>R4W4H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4234 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446026.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05915"/>
    <dbReference type="EnsemblBacteria" id="AGN01132">
        <property type="protein sequence ID" value="AGN01132"/>
        <property type="gene ID" value="L593_05915"/>
    </dbReference>
    <dbReference type="GeneID" id="16181543"/>
    <dbReference type="KEGG" id="sali:L593_05915"/>
    <dbReference type="eggNOG" id="arCOG12943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177454_0_0_2"/>
    <dbReference type="OrthoDB" id="121610at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025328">
        <property type="entry name" value="DUF4234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14018">
        <property type="entry name" value="DUF4234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4234" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="12229" checksum="A49F23D40776E5EE" modified="2013-07-24" version="1">MPTVTDPSAFEEGSLGLQIVLFIVTFGIYGLYWYYSTNAQLAAGTDAEFSPVARTLLSLLPFLGLYWSWQFCNDAEAVTDQSGPLLFVLFIVFAPISWFLIQSGVNSTAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4R6</accession>
    <name>R4W4R6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446186.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06725"/>
    <dbReference type="EnsemblBacteria" id="AGN01292">
        <property type="protein sequence ID" value="AGN01292"/>
        <property type="gene ID" value="L593_06725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181503"/>
    <dbReference type="KEGG" id="sali:L593_06725"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_0_2_2"/>
    <dbReference type="OrthoDB" id="55420at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="37864" checksum="EA39D8B7B4336C65" modified="2013-07-24" version="1">MFERLALPTPFQVGPVNAYLAEQTVVDPGPDGEDVRNALGDELAERDLAMTDVEQVLVTHAHPDHFGLAHHLSEQGADVLASPEAAAIMRDFEGRLDYEQAYFTELFQAHGMAPETTQTVTQLPEAFVEYAPDVEVDRELTAGDTVPIDGTQFAVRELAGHSEGELAFEWDDEPGAPGESDDEGTDGGQPRFTAIVGDNVLPDTTPNPFLQPPAREDGSIEAPEYEDLLELDDLRPRPLPEFNDSLDELQAAGHDRFLPGHGGIIEDPQGRIDEIRAAHERRSEAVLEIVEGPTTAVEVMRGLFPDLAVIDYFPGMSEALGHLDVLVERGEIVREVRDGGLVYVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W529</accession>
    <name>R4W529_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal flagellin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446376.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07685"/>
    <dbReference type="EnsemblBacteria" id="AGN01482">
        <property type="protein sequence ID" value="AGN01482"/>
        <property type="gene ID" value="L593_07685"/>
    </dbReference>
    <dbReference type="GeneID" id="16182188"/>
    <dbReference type="KEGG" id="sali:L593_07685"/>
    <dbReference type="eggNOG" id="arCOG02911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308522_0_0_2"/>
    <dbReference type="OrthoDB" id="44359at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="998" mass="104054" checksum="1861EEFAB9755C5A" modified="2013-07-24" version="1">MSRRSGAGGGTEARTARHRGQSEIIGLVLLLGAILIGAFLTIAIGGMALQSVQENAQGGLTQDTAQQAHAALSEAAVTGDPQAIPMGEGPVDGRLVDGGTLTISMHDGPDTCSRAVREELGALRYQGGDRAVIYEGGAIWAETEAGLAVDRAPPISYDGGTTRISVLSVSAATTTDDGQLVARPNESARRRLAEETSSLLTVCPARDYTDLRITVSSPYSDGWERHFEQRVNTTSNVTVTRLDDDTVQATIENATEPRDFDGLAIPYVGAAVAVSPGEHFTPEVHVANGNYSATTGTVELRIDGTSITRTRPVSVDAFDVNRSTSFNVSSSTINASLTVGETYNYTVAVRNDTGTTVDARNGSFVAGTHGPMVRLTRLNETMDTSEQQLTIGAALRNYGLQNGTGSVTLEFTDPVVAAPNRTASGIRVNGTGTTTVGFQLDVGSLPVGHYEYAVHGPNGTLHSAFVIGNRTETTPIAGDLRLRNVSTAGTTVTEDDAFTVDTTVENVGGDPTNGGVAFRLEGGPNANVPVSLDPGELGSNSFSLSPSQVSALETGETHEYEIELASGNDTETVTGAFYLGESGSALGVEALNATQDDGTVTVDATLDNDGLANATDNATLTMYEANGSGDQVTFAETPTRTVSVRWGATKTVSFQFDGSSLGGNYTISVDYGNETGSDVVNLGALEGGDGDVAISGAGNGTVRVLGTEVSGTNDWYDRKYWAPISVTSVLTVDGSQSHHTFTNDETEDPGSLHTLTNLNSYDTQNATYSYDWTQEAGETSTLTVASTLWSRSGPWEYANTRTYGGETWEDYQAEASAYDDAYNEVNASSGDNPSNVRVLLDGDDVPGVHAAGDQQRSAAEILNQGAADRVDDDGTLDLGPNEAVFLFELSDRTATWAEADDDPGEDPDYNDVIAIVEFETPDGAVPVDMEVTDDGTGLVIGSPSVTAPSNTTISPGSITNSSSSGAPDVYAPGANGTLPGGPTPPEDVDVSVDVVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W531</accession>
    <name>R4W531_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TrkA-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446381.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07710"/>
    <dbReference type="EnsemblBacteria" id="AGN01487">
        <property type="protein sequence ID" value="AGN01487"/>
        <property type="gene ID" value="L593_07710"/>
    </dbReference>
    <dbReference type="GeneID" id="16182197"/>
    <dbReference type="KEGG" id="sali:L593_07710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1580"/>
    <dbReference type="eggNOG" id="arCOG01960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035216_0_0_2"/>
    <dbReference type="OrthoDB" id="29208at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="277"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="489"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="571" mass="60947" checksum="C949FC76441C0DF9" modified="2013-07-24" version="1">MRSLTEFGDLTPRNLTKRQRLVGLLAIAIGSVVLFYTVFYYLGMRTLEDRPRSIFHSLQIVVETMTTTGYGADSPWDSPWMNLYMVAMQFSGVLIGLATLRVLVIPLFEQTPLNLDDRLTPKRDHVVVAEYKRDTGVLLDELETLDVDYVLIESDEEEAKRLSDDGYQAINGDPEDAKDLERATIRKASLLITDAGDATASVVLTALEMNEDLRVVSFTESARRTAALAEVGVDRSVAPHALIGRRLAEKATTPVSIDGGPGGERLSEDVGGERDAGGEAPSATSGVGVREILVRRDSPLHGVLVGESPLAAHPSLTLVAGWFDGHLQVPPAPDARLTPNAVLVVAGPEDEIDALVGEVGGVSSPQAARHERIVVAGLGEGGRSAVEVLPATANATTIDEDESREPDVVGDVTEPGTLEAAGIDDASALVVTVDDDASALLTIAMARSLAPDVEILARVTDAAKTAPAFRAGADYVLSVQRVCARLVANEVYGERVVDFASQLRIVRVESAAFVGETLGELRERRDRGWTVVGVVRSDGVRTDAGIEVVESDEVLVAGSDEAIQEFERAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5R8</accession>
    <name>R4W5R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446796.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09785"/>
    <dbReference type="EnsemblBacteria" id="AGN01902">
        <property type="protein sequence ID" value="AGN01902"/>
        <property type="gene ID" value="L593_09785"/>
    </dbReference>
    <dbReference type="GeneID" id="16182751"/>
    <dbReference type="KEGG" id="sali:L593_09785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2014"/>
    <dbReference type="eggNOG" id="arCOG01511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_1_2_2"/>
    <dbReference type="OrthoDB" id="4114at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="228"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="723" mass="74960" checksum="4D8D48ADF47F127A" modified="2013-07-24" version="1">MSNPSVGVDVGGTFTDVVTVADGDLAVTKAPSNPDAPEEGVLDALDRAADTEGLSLPAIDSLVHGTTVATNAVLEGTWANAALVTTEGFRDVLEIGRQDRPELYDLTASKPDPIVPRDRRFEVPERLDERGEVRTPLDDSAVEAVANEIATAGSTAGGSDVAAGGGDVESVAVCLLFAYENDAHERRVAEVLRERLEDRSGRAGTGGDRSVPVTISADVLPELREYERTLATALNAALLPVMSEYVETLADGVANRGCEAPLEIMTSGGGLVGTEHARDRPVETLLSGPAAGVQGAAYVAGLRDTDDAITMDMGGTSCDVSLITGGEPTVTTERTVGDYAVAVPAVDVHTIGAGGGSIAWLDDGGALRVGPRSAGAEPGPVCYGRGGAAPTVTDAQLLLGRLDPGSLIVEDGADRGAVEEAMRSHVAGPMDSSVEAAARGVLEVANANMERALRVVSVERGHDPRQFDLVAYGGAGPLHATALADSLEIPRVLVPRTAGALSALGLLSTDRLHSLSTSMVRPLADVEPATVADVLAALEAEGRSRFDAGDRDADGGSTDPLVVERRLDLRYVGQASELTVELPGGGGSADRTEGGAPIDDDALAAAADRFHDAHEQRFGHAARDEPVELVTVRVRVREPIEAPTLRPPTTASDDPDDAIVEERPVAFGEDWHDAPIYDRELLPAESSFAGPAIVEGPESTVTIRPGQTATVDEHGTIVVEVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Z6</accession>
    <name>R4W5Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446921.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02027">
        <property type="protein sequence ID" value="AGN02027"/>
        <property type="gene ID" value="L593_10410"/>
    </dbReference>
    <dbReference type="GeneID" id="16180565"/>
    <dbReference type="KEGG" id="sali:L593_10410"/>
    <dbReference type="HOGENOM" id="CLU_2597906_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8176" checksum="CE1C236F3AACFA51" modified="2013-07-24" version="1">MAIAVTDLLWSALFVLLYLLIAAVAIVGAVGIPAFVGKMVYDRAQSEDLSNPAGIGLGAAFFTVLVGLFAIGVLLFYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W674</accession>
    <name>R4W674_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447051.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11060"/>
    <dbReference type="EnsemblBacteria" id="AGN02157">
        <property type="protein sequence ID" value="AGN02157"/>
        <property type="gene ID" value="L593_11060"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4010" evidence="7">
        <location>
            <begin position="188"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="43271" checksum="5EF774FC10699634" modified="2013-07-24" version="1">MSIALQLGRAPLEEPVVRLVLAAALGLFLGLEREWSEKAAGVRTFALTSLLGASLLLLEEPWLLALGAVLALAQGAMLSIQGLLDPDRGLSLTTWVALFVAYAVGALVAAEFVLEGVAVTVVTSLLLLEKRELHSFAGGLSRPELRSVSEFAILAFVIYPLLPTGTVELAVQSVTVSLEPRVAWAMVVTVAAIGIGNYAIVTTYGGRGVAMTGFVGGLASSTAVVGTMVDYVRQRPDASGYAVAAILLAVAAMAIRNLAIALTFTIGRGLLVDVAVPLVAIVLAAGLLAARSAEWSEPVEFDLESPFSVRNVVGFGAVFAVVLVAGSIAEQELGQLGFYAATAATGFVSSGGAATSAVILYRSGTIDASTATIGILLASGASIVVKVGLTALGGDHRFAREVAIRSAILLVVAAVATLFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I8</accession>
    <name>R4W6I8_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Response regulator containing chey-like receiver domain and arac-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02335</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Archaea</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="STRING" id="1333523.L593_02335"/>
    <dbReference type="EnsemblBacteria" id="AGN00418">
        <property type="protein sequence ID" value="AGN00418"/>
        <property type="gene ID" value="L593_02335"/>
    </dbReference>
    <dbReference type="GeneID" id="16180175"/>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.473"/>
    <dbReference type="eggNOG" id="arCOG02391">
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    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13245" checksum="D1928727E97AE43D" modified="2013-07-24" version="1">MPENVMIVDDSDFMRNLLREILDEEHHIVGEAENGVEAVELYREAEPNVVMMDIAMPIRDGIEATAAIKDESPGASVIMCTSVEQEEMMKEAIKAGADGYITKPFQKPNVLEAIDDAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N5</accession>
    <name>R4W6N5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_02685</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00488">
        <property type="protein sequence ID" value="AGN00488"/>
        <property type="gene ID" value="L593_02685"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02685"/>
    <dbReference type="HOGENOM" id="CLU_2730577_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="7059" checksum="2B3F25084004DD18" modified="2013-07-24" version="1">MTMKNGKSLAWALLVLGIVSIVAGVYRTGASGEISLLLITGMGATTVGMVLHDGLTDGAAEGANSEPGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W782</accession>
    <name>R4W782_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13940"/>
    <dbReference type="EnsemblBacteria" id="AGN02727">
        <property type="protein sequence ID" value="AGN02727"/>
        <property type="gene ID" value="L593_13940"/>
    </dbReference>
    <dbReference type="GeneID" id="16180963"/>
    <dbReference type="KEGG" id="sali:L593_13940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2852"/>
    <dbReference type="eggNOG" id="arCOG06324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109224_0_0_2"/>
    <dbReference type="OrthoDB" id="107155at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="16478" checksum="31AD68D9EF6095F6" modified="2013-07-24" version="1">MPTPDPASVVADADVLAADLLVDGAARQALDVVRSHSWIDLVASDPLLDDAEAVIASRSDADLAADWRERIEAERRSVPHPAGDHPGLASALHGDAAHLLSFDENLTSAAAGVGLHGHVSVSVRTPDAFLAVFDAKSLYESLDERSYPGPDRDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C3</accession>
    <name>R4W7C3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Quinolinate synthase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_04695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445782.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04695"/>
    <dbReference type="EnsemblBacteria" id="AGN00888">
        <property type="protein sequence ID" value="AGN00888"/>
        <property type="gene ID" value="L593_04695"/>
    </dbReference>
    <dbReference type="GeneID" id="16181015"/>
    <dbReference type="KEGG" id="sali:L593_04695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.959"/>
    <dbReference type="eggNOG" id="arCOG00572">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_2"/>
    <dbReference type="OrthoDB" id="8547at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="entry name" value="NadB"/>
    </dbReference>
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        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succ_DH_flav_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="477"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="567" mass="60302" checksum="D1F68AE512FFEDD9" modified="2013-07-24" version="1">MVESHTADEREEQRPQDPETADVLVVGSGIAGCAAALAAARDGADVLLVTKAERPEDASTDWAQGGIATSRDDPAALKEDVIAASDGTADPDAVDVLVEDANEAVEDVLLDTLEVPFDTADADEVPADADGEDAAGATDADSEFDYTREAAHSDRRILHVDASTGTHILRPFLNHLDSRDDVRIREDTAALELITHEGRVHGALLDSEPEGEPVYAGTTVLATGGIGACYPRSTNPPDATGDGIAMAALAGADVEDMEFVQFHPTAFDPDAGTEDATAGADGAGGEDERGSNIFLLSEALRGEGAILRNGDGERFMPDYHDDAELAPRDVVARAVDRERSATGEVRLDVSPVDFEGEFPDLVELCEDNGVDWAEGIPVAPCEHFLCGGVAVDDRGRTSLDRLYAVGECSRTGVHGANRLASTSLLEGLVWGLRAGEDAVATVEDAGEAGDPEVVEAAELLNRDPDLPERFAAEKFVRLRRVMDEHVGLRRDPEGLRRAAAVLRRLKGEVDAYVRTRTSRDLYELRNASVTALLISRAATEREESVGTHYLVDEEAEAQSSGQSVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D3</accession>
    <name>R4W7D3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AGN00908.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00908">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
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        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13483" checksum="6C74F4C85977387F" modified="2013-07-24" version="1">MAERYSSFEPNGTSWLLQRITAALLVVLLAFHFFQLHFLNHAYEVTFAGTRARMEDPAYFATMVLFLVTAAFHGVNGIYNALVNQGIQGARKRVAKYGLILAGLVLVGQGIRVAMAMAGVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E0</accession>
    <name>R4W7E0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronate 5'-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445812.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04845"/>
    <dbReference type="EnsemblBacteria" id="AGN00918">
        <property type="protein sequence ID" value="AGN00918"/>
        <property type="gene ID" value="L593_04845"/>
    </dbReference>
    <dbReference type="GeneID" id="16181592"/>
    <dbReference type="KEGG" id="sali:L593_04845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.990"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="36574" checksum="1B654C17B7680612" modified="2013-07-24" version="1">MTVLVTGGAGFIGSHVTHALLEEGHEVVVVDPLDPYYDVGIKERNLEIAREIAPERFEWVDGSITDQSLVEDLFAEHAFDFVYHEAAQAGVRTSVENPLKPHEINTTGFLHVLQAADEAGTERVINASSSSVYGRPDYLPYDEEHPNYPKSPYGVTKLAAEHYGKVWTDVFDLPVVNLRYFTVYGPRMRPNMAITNFVSRCLNGEPPVIYGDGQQTRDFTYVEDIVSANLALLDTDAADGEDVNVGSTDTITIEELAEHVIDVTGADVDLVFDDAKEADARHTHSDVSKARELFDYEPTTDIREGVEKFVEWYEANREWYEPLVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G7</accession>
    <name>R4W7G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445852.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05045"/>
    <dbReference type="EnsemblBacteria" id="AGN00958">
        <property type="protein sequence ID" value="AGN00958"/>
        <property type="gene ID" value="L593_05045"/>
    </dbReference>
    <dbReference type="GeneID" id="16181057"/>
    <dbReference type="KEGG" id="sali:L593_05045"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_2"/>
    <dbReference type="OrthoDB" id="88480at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000035">
        <property type="entry name" value="Alkylbase_DNA_glycsylse_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00516">
        <property type="entry name" value="ALKYLBASE_DNA_GLYCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="4">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="190" mass="20837" checksum="E1557D6EA88F110A" modified="2013-07-24" version="1">MPSPSDTLESDPHLGPLWETHGPVAIEPAEDLFERTIVSIVNQQLSVDSAAAIQERLFDAVEITPAGVLAAEESTLRETGLSGSKVEYVRNVARAFEEHGYDHAYFEGMPDDAVADELTEIAGVGPWSAKMFLMFGLGREDVFPVEDLGIRAGMSEVVDPELTRAEMRDHAEAWAPHRSYASLLLWNAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J5</accession>
    <name>R4W7J5_9EURY</name>
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        <submittedName>
            <fullName evidence="6">Alanine--glyoxylate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_15065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447841.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15065"/>
    <dbReference type="EnsemblBacteria" id="AGN02947">
        <property type="protein sequence ID" value="AGN02947"/>
        <property type="gene ID" value="L593_15065"/>
    </dbReference>
    <dbReference type="GeneID" id="16182297"/>
    <dbReference type="KEGG" id="sali:L593_15065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3077"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_2"/>
    <dbReference type="OrthoDB" id="20398at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="36"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="370" mass="41720" checksum="284A41006A18C618" modified="2013-07-24" version="1">MTKKQEYTGDYDDKTLYIPGPTEVREDVIEEMAQPMFGHRMDRMTDLYTTIVEDTKEFLGTDNEVIILTASGTEFWEASTLNLVDENILVPTCGSFSERHANVAERLGKNVDRLEYDWGQAIKPEDIRAELESSEKHYDVVATVMNESSTGVRNPIEEIGDVVAEYPDTYFVVDAVSALGGDYVDIDEHGIDVIFASTQKAFAMPPGLAVCVVSDEAYDRELEKDSASWYGGFQRCLDYYDRKGQTHSTPAIPVMLAYRKQMKYMLEEGHQERSERHAEMTEYTHEWAREHFDLFAEEGYRSQTVSCIENTQGIDVAATIDAVSEEYDMAFSNGYGSALGEKTFRIGHMGEHDVESIRALTDAIEDVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S2</accession>
    <name>R4W7S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444908.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00295"/>
    <dbReference type="EnsemblBacteria" id="AGN00014">
        <property type="protein sequence ID" value="AGN00014"/>
        <property type="gene ID" value="L593_00295"/>
    </dbReference>
    <dbReference type="GeneID" id="16181309"/>
    <dbReference type="KEGG" id="sali:L593_00295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.59"/>
    <dbReference type="eggNOG" id="arCOG06405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022162_0_0_2"/>
    <dbReference type="OrthoDB" id="50267at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="514" mass="56993" checksum="712D0E9215E2C096" modified="2013-07-24" version="1">MAEVASPSARDRIGAGVDWLAATTVDRIAIDLRALAALRIALGSLLLVDLLLRTRNFVVFYTDRGIYPLSYLNPALAEPYSVHAFDGSVEFQALLFVIAGLFALSLLLGYHTRTATVVSWFMLLSLHTRNPLVLNSGDVLFRMLLFWGIFLPLGERWSIDARRVDRDRIAVASLGTLALLVQIVLVYTINAVHKLRSEEWLDGSAVPTIMHLEHFTVYLGPYLAEVQPLLRLVTWVWLTLVVVVAPLLLLLTGWPRALLASAFAGMHLGMATTMAIGIFPFVSVSGLLVFYHRPIWDRLEAVATERGLSPLLGATLDRLDRVAPLPRLRTRPRDLLPDGVPDPGPTVASIVLVLMIPSVVLSGAASVDYAEVPDPGDELLDHTEMDQHWQMFAPNPADTSRWYVGVGNLTDGTRVDPYLGGAPSFDRPPNPATTVRTARWRKAIVYTQYHSLSHTPNHLGNFLCEHWNRTHDTQLATVSIYAMQREVGPDGPETPIERDVVVDHYDCSEDRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V3</accession>
    <name>R4W7V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01223">
        <property type="protein sequence ID" value="AGN01223"/>
        <property type="gene ID" value="L593_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06380"/>
    <dbReference type="eggNOG" id="arCOG05223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178168_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="235" mass="26814" checksum="7E8CF462ED89E3CE" modified="2013-07-24" version="1">MDAAVETTLEESNAVRVPNDRPRLLPQDQDRAFFRDSVLGDRSLTADTPSQTRLERAHRDLRDEFRESGSESDVSKLTSRLLYDFEIDVVEVDDDAGAASIFESTDDRGKPLSSLEDTKSFLMNVDDRAAVDRSLRNESNDRFGGLYRELFVLEDGHSHVDDFDEDSLQQSTGALYDGFDADEYCNNFDTLQQPLYEPYRYADHDDVTRSCGRELAQGASPHQSNRFLSPRIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y1</accession>
    <name>R4W7Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445053.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01030"/>
    <dbReference type="EnsemblBacteria" id="AGN00159">
        <property type="protein sequence ID" value="AGN00159"/>
        <property type="gene ID" value="L593_01030"/>
    </dbReference>
    <dbReference type="GeneID" id="16182452"/>
    <dbReference type="KEGG" id="sali:L593_01030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.211"/>
    <dbReference type="eggNOG" id="arCOG04682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_2"/>
    <dbReference type="OrthoDB" id="57234at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="40858" checksum="BC0CB07433B25A78" modified="2013-07-24" version="1">MPDRSQEYFERLVDLDALEAFLEAELGPVDHYEVERHEQGHSNETLFVQWGDDELVVRRPPPGATAETAHDVLREYAFIDALQDTAVPVPSTVTSTDDHSVLGSDFYVMERVEGTVLRAGEPPAFANAEAREQTGSELVDTLAAIHGVDTDAVGLDDFGHPEGYTERQVARWGTQLAWAFEVTADEREVPELERVGDWLAEHCPEEHPHTLVHGDYKLDNVMFGPQRPVELVAVFDWEMATRGDPRSDVGWMLSYWRDAKDPDPVVEELVADFMEHPDYPTRRALVERWEEQTGLEYAEEHDRFYRTLAVYKLAGLGEMFYRRYLEGNADNPMYPKMEERVPALAERAIRIIEGEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W815</accession>
    <name>R4W815_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446312.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01418">
        <property type="protein sequence ID" value="AGN01418"/>
        <property type="gene ID" value="L593_07365"/>
    </dbReference>
    <dbReference type="GeneID" id="16181504"/>
    <dbReference type="KEGG" id="sali:L593_07365"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_0_0_2"/>
    <dbReference type="OrthoDB" id="27311at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator_TrmB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="27307" checksum="F07F21780452EDF7" modified="2013-07-24" version="1">MREQHYRNLEDRAAALSSLRDLLATATDLVICSAPSPLVGELTPELDAALADDVLVLLLVGGEVETSTGERPYPATLVRHWERPIDFVTAASVDYDRGFYTEAELHDSDGQAGRALRYRDQFFGDLQLNTMLFAWWQRSSELYAADPAPLPTTHDSFFRAVIDAARFLREDQPLAARIEGRTTDTNEPATVDGEVINVRQSIISPATNSFPIEQSIFVASTDGVVSAGSQSAQVEDLRADRVEFYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W843</accession>
    <name>R4W843_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07665"/>
    <dbReference type="EnsemblBacteria" id="AGN01478">
        <property type="protein sequence ID" value="AGN01478"/>
        <property type="gene ID" value="L593_07665"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1571"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438458_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="39"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="584" mass="62722" checksum="BD0170B5D8F08B9C" modified="2013-07-24" version="1">MVTMTERAAADDDVRTDGGTATQRVATDGGSMDEHEHYEAIVVGCGPGGAAAAAALAANDVETLVLERGVDAGSKNVSGGLIYAEESAPYTIDDLFPDFREEATERPAVEYKMHNCSEEKVATFDLESIHNKGTEWCDAVLRRHMDSWLAEQVHERTRETGGGLLTDVRVNGLLRENGEIVGVTCDELDPITADLIVAADGVNSELARDAGLMDWEEPDDWFQGVKAVVDMDRETIEERFDLDGPDDGAAHLFSGDLFEGVRGGGFLYTNEDSLSIGTVFHLDSIADERAEPQDLLDALLTHPLLDQWFQGEYDELEYSAKLVPDSKKVANPSPHQGRLLLVGDAAGQMQAQGPIIKGMNHAVSAGGLAAEAFQDAKTRGDPSAAGQLYEQKLNDEGVMDKLRPTRYEATSWLSESSVMTSIGSAVLNSPVGRFGVKTFDGLLEKSFNSPFVLGMIPDTKISYVTVPTVIGDVLGEPVSAEHEIEPPDLADRIGDLTYDVGDPHIEVLDNSYEASGTAVTACPVSAEEFGGGCYRSETIETNGDTERVVSLDTQPCVECGTCAVVADTHWEHPAGGKGVEYKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W858</accession>
    <name>R4W858_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">L593_01940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445233.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01940"/>
    <dbReference type="EnsemblBacteria" id="AGN00339">
        <property type="protein sequence ID" value="AGN00339"/>
        <property type="gene ID" value="L593_01940"/>
    </dbReference>
    <dbReference type="GeneID" id="16182069"/>
    <dbReference type="KEGG" id="sali:L593_01940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.395"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OrthoDB" id="51351at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="34375" checksum="AB51AE9FE07C8ACC" modified="2013-07-24" version="1">MRHDHVLTARQLSREDVEEVLDRAAEIAADPDAVSDRHAGALLATCFFEPSTRTKMSFEAAIKRLGGDVVDMGSVESSSVKKGESLADTMRVIEGYADAIVLRHPKQGAAKMASEFVDVPLLNAGDGAGHHPTQTLLDLFTIREAQGLDDLTIGIMGDLKYGRTVHSLAHALTTFDARQHFISPESLQLPRGVRYDLHEAGAQVREHTELEEVLPSLDVLYVTRIQRERFPDENEYRKVAGEYRIDSETLEAADDDLAVLHPLPRVDEIAPEIDDTEHAQYFQQAHNGVPVRMALLDLLLDGAAVGAIGGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E8</accession>
    <name>R4W8E8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445498.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03265"/>
    <dbReference type="EnsemblBacteria" id="AGN00604">
        <property type="protein sequence ID" value="AGN00604"/>
        <property type="gene ID" value="L593_03265"/>
    </dbReference>
    <dbReference type="GeneID" id="16180478"/>
    <dbReference type="KEGG" id="sali:L593_03265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.661"/>
    <dbReference type="eggNOG" id="arCOG04591">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782471_0_0_2"/>
    <dbReference type="OrthoDB" id="109198at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15958" checksum="E837D57D9CB98B39" modified="2013-07-24" version="1">MDPTSIFGPLDLLYPHAAYVLFVLVLLNAITRQVAHRRHVSQYEEGGAEAVARFTPHTISNALLFLAAVYYTTVKFEAGTIVVVLVIGVIITDFFEFEARKAEARTDRSLDVPKGALTAWAVAATYISYKALRFIVDPLWGVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H3</accession>
    <name>R4W8H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445543.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03490"/>
    <dbReference type="EnsemblBacteria" id="AGN00649">
        <property type="protein sequence ID" value="AGN00649"/>
        <property type="gene ID" value="L593_03490"/>
    </dbReference>
    <dbReference type="GeneID" id="16180595"/>
    <dbReference type="KEGG" id="sali:L593_03490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.708"/>
    <dbReference type="eggNOG" id="arCOG09395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037493_0_0_2"/>
    <dbReference type="OrthoDB" id="48757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="38967" checksum="A316650B17E93BA0" modified="2013-07-24" version="1">MPSRRTVLEAIAGLATAGAVGLAGCLEQGGSADPPSSDPDAAVGPSPPTAERNLPRAYSMQELRDAVLNGGVSQDGIPSIDDPSFESPNSAGLDDGDPVFGVERNGEAKAYPQRVLVHHEIVNDRLGDEPVAITYCPLTGTVQGFRRGDTEFGVSGNLLNDNLVMYDRATESWWPQILATAIAGDHVGHELQEFEVTWTTFGRWTGAHPDTAILSEDTGYVRDYGDDPYGEYNPKDAYYQNRGIFFDVTNEDDRLHPKTVVMGARTADGALAIEKEAIRSAGVRETTVGGTPFVAVYEPSLDTAVVYRNAEDRDLGHDGERPTVDGEAFDPESLPLERVISFDAMWFAWAADYPNTALVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L3</accession>
    <name>R4W8L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446807.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09840"/>
    <dbReference type="EnsemblBacteria" id="AGN01913">
        <property type="protein sequence ID" value="AGN01913"/>
        <property type="gene ID" value="L593_09840"/>
    </dbReference>
    <dbReference type="GeneID" id="16182575"/>
    <dbReference type="KEGG" id="sali:L593_09840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2025"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OrthoDB" id="31525at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="183"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="36733" checksum="4EBD77E1406081F7" modified="2013-07-24" version="1">MQAARLHEYTDDMSEGLTVEEVDRPAVTGANDVLIEVTGAGWCQTDNHIIEGMWEPYVTQPLPMTLGHENAGIVAETGDEVHIVEEGDPVICHPVQTCGTCRACRLEETMYCENQSFNGLTTDGGFADYLLTGERSVIPLPEGVDPTDIAPHADAGITAYHAAKKAVHELNPGDYALIVGIGGLGHIGVQCVDAMSAAEIVAVDVKDEALSLAADGGADHIVNPTKGDVREFVDEVTDGHGVAQVLDFVGADETTAYAPDVTASGGDHHVIGYGGHVHAPAQSLVNGEFSFVGNIVGRYSELQELVALVERGDVELTTSRYDLEDINEVAERLEHGEIEGRAVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P8</accession>
    <name>R4W8P8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10215"/>
    <dbReference type="EnsemblBacteria" id="AGN01988">
        <property type="protein sequence ID" value="AGN01988"/>
        <property type="gene ID" value="L593_10215"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10215"/>
    <dbReference type="eggNOG" id="arCOG08021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187344_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8379" checksum="0F2F72D5E1C018DE" modified="2013-07-24" version="1">MSASTEQKLAGVAAAELEIPDGLDTAQSKLCYLALDAAGTATIDELDGTLDLGKLCLLSVLGELEDAGHLQRTADGRYATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U1</accession>
    <name>R4W8U1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446982.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10715"/>
    <dbReference type="EnsemblBacteria" id="AGN02088">
        <property type="protein sequence ID" value="AGN02088"/>
        <property type="gene ID" value="L593_10715"/>
    </dbReference>
    <dbReference type="GeneID" id="16182337"/>
    <dbReference type="KEGG" id="sali:L593_10715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2209"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_1_0_2"/>
    <dbReference type="OrthoDB" id="79103at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="161" mass="18064" checksum="9ADCAE22A3F25DEE" modified="2013-07-24" version="1">MNERELLDLLLADARRSTEDLARMLDADEAAVADAIERLEDEGVVGGYSAIVDWGEVDEERVVALVELNVTLDRETSYADIAERLARFPEVQTLQLVSGDYDFDMRVEGDSMREVSRFISDKVAPVPEITQTVTHYVMDTYKDRGVNFGDGDDDERLSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U7</accession>
    <name>R4W8U7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445838.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04975"/>
    <dbReference type="EnsemblBacteria" id="AGN00944">
        <property type="protein sequence ID" value="AGN00944"/>
        <property type="gene ID" value="L593_04975"/>
    </dbReference>
    <dbReference type="GeneID" id="16181109"/>
    <dbReference type="KEGG" id="sali:L593_04975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1013"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="35458" checksum="3A399EFFB037730D" modified="2013-07-24" version="1">MSRPHAVVTGGAGFLGSHLVDALLDDGYRVTSLDNFGSGRESNLEHVESDHFESRRHDVREPFPVFDRVDEVYHLASRASPDDFVDHAVEIALTNSEGTHNAYECGLEHDAPVLLASTSEVYGDPDVNPQPESYTGNVNVRGPRAPYDESKRFSEALAIAYDQQYDLDVRTVRIFNTYGPRMRPDDGRAVPNFLSQALRGEDLTVYGDGSQTRCFCYVSDLVRGFRTIMEADADVVSGEAFNLGSTEEITIETLAKTVLEVLDTDSEIAYRELPEDDPKVRHPDLSKTDAALDWDPRVSLKEGLRRTAEELAAELDLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y9</accession>
    <name>R4W8Y9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpl39e</name>
        <name evidence="7" type="ORF">L593_05575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445958.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05575"/>
    <dbReference type="EnsemblBacteria" id="AGN01064">
        <property type="protein sequence ID" value="AGN01064"/>
        <property type="gene ID" value="L593_05575"/>
    </dbReference>
    <dbReference type="GeneID" id="16181434"/>
    <dbReference type="KEGG" id="sali:L593_05575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1139"/>
    <dbReference type="eggNOG" id="arCOG04177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_4_0_2"/>
    <dbReference type="OrthoDB" id="131584at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_L39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="50" mass="6083" checksum="CDD04FD261F62641" modified="2013-07-24" version="1">MSKKSKAQKKRLGKLERQNSRIPAWVMLKTDREVTRNPKRRNWRRSSTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z1</accession>
    <name>R4W8Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445963.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05600"/>
    <dbReference type="EnsemblBacteria" id="AGN01069">
        <property type="protein sequence ID" value="AGN01069"/>
        <property type="gene ID" value="L593_05600"/>
    </dbReference>
    <dbReference type="GeneID" id="16181490"/>
    <dbReference type="KEGG" id="sali:L593_05600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1145"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_4_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14790" checksum="DDEAF1BA409784FD" modified="2013-07-24" version="1">MPPSHVLVVLDGSPRAEAALEHALVEYDCTITVLNVITPVDAGMSEGSILDPDDEREREARERAERLAAEADATAPTVEPVVVADTPVDAVLDYLSEHDVDHVVMGGHGGPRHEIVERILGTVATEVADAAEVPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W916</accession>
    <name>R4W916_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447162.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02268">
        <property type="protein sequence ID" value="AGN02268"/>
        <property type="gene ID" value="L593_11625"/>
    </dbReference>
    <dbReference type="GeneID" id="16181359"/>
    <dbReference type="KEGG" id="sali:L593_11625"/>
    <dbReference type="eggNOG" id="arCOG04577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142036_0_0_2"/>
    <dbReference type="OrthoDB" id="86304at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="17573" checksum="EA14C425D43F2074" modified="2013-07-24" version="1">MALDVSTPAPPELEPIDPEEYDDVEVVSDTDYRREEIGDFLEDGAWEESFDTWREDSDMDEDTFAVVEDLGLFEDFDFFWDSFADRVGYHSPGVPENWKERDIHPELDTWERASTINAELAELGQIVCDVLKADYIDWESEYEAPDDLPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W991</accession>
    <name>R4W991_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447377.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12720"/>
    <dbReference type="EnsemblBacteria" id="AGN02483">
        <property type="protein sequence ID" value="AGN02483"/>
        <property type="gene ID" value="L593_12720"/>
    </dbReference>
    <dbReference type="GeneID" id="16180138"/>
    <dbReference type="KEGG" id="sali:L593_12720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2610"/>
    <dbReference type="eggNOG" id="arCOG08925">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759956_0_0_2"/>
    <dbReference type="OrthoDB" id="24374at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="384" mass="41996" checksum="569B0DA55AA0A35C" modified="2013-07-24" version="1">MSQTSPEGQAAEYSIRPYESGDADRFLSLYETVWGTTKSRAWFDWRFAANPRSDGIEMIVAEADGQLVGAEPLLPYRLRAGDEVLDAYQPVDWIVHPEYRRQGIFSAMTESLLSSVGADADLLFNFPNEQLLPGIQKFDWQAIATATCRYRVQDPAAVAMREATGSRSTPSLFATAASPIVRGGLRMCDRFAPAHADVSISRVRGVPVETVSERYDASVPPKLHVPRDRAYLEWRFANPRWETTTYVARRDGGVVTTAVVASESVDGSQLVRVLDVQPMTEAVGDAEAFEAIVRAVVTDNPDASVLKAPTGLFPGVLRRSGFLRDDSFPLSRFSAATYHAVRPLDDAFEPAAASTDDGAGHRGDALDLTDPDDWLLALGDHDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B1</accession>
    <name>R4W9B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06960"/>
    <dbReference type="EnsemblBacteria" id="AGN01339">
        <property type="protein sequence ID" value="AGN01339"/>
        <property type="gene ID" value="L593_06960"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1422"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="244"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="36902" checksum="4C20C336C2FEB15A" modified="2013-07-24" version="1">MLTTLGTGTLAAVAGCSQTFEEASDDEPVGLTRAAGLPSQEAQGTEYTEVYQEAIDSVALLQVYGGQAGQGSAFVFDGDYLVTNHHVVEGADTIDVQYADNDWTGAEVVATDAHTDLGVIEVDERPAYATELPLAEERPVVGQEVMALGNPLGFDSSISVGIVSGRNRTLSAPTGFSIPNAVQTTASVNPGNSGGPLVDMDANVVAVINSGGGDNVGFGISAAVTRWIVPTLIEEGDVAHTYVGIRTYPVDRRVAEANDLDEVRGVMVSEVVGGGPADGTLQGVEEWETRNARRIPIGGDVIVAIDGTRLPTRHDLSTYLALETAPGDTVEITVLRDGEERTVEMTFGQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F3</accession>
    <name>R4W9F3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ORF">L593_13395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447512.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13395"/>
    <dbReference type="EnsemblBacteria" id="AGN02618">
        <property type="protein sequence ID" value="AGN02618"/>
        <property type="gene ID" value="L593_13395"/>
    </dbReference>
    <dbReference type="GeneID" id="16180586"/>
    <dbReference type="KEGG" id="sali:L593_13395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2740"/>
    <dbReference type="eggNOG" id="arCOG01323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_3_0_2"/>
    <dbReference type="OrthoDB" id="88531at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14538" checksum="B6315D6A763E797A" modified="2013-07-24" version="1">MSRLGLVVAQFNRSVTEPMEAEAHEAAEDRDAEIVETVSVPGVYDAPLAADRLARQDSIDAVAVIGAVVTGDTDHDQVIAQSCADALSEVSLDRDLPVTYGVSGPGMSGAEARERTDVGSRAVESALSLLEELPESDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G9</accession>
    <name>R4W9G9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01504">
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        <property type="gene ID" value="L593_07795"/>
    </dbReference>
    <dbReference type="GeneID" id="16182238"/>
    <dbReference type="KEGG" id="sali:L593_07795"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
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        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="31041" checksum="BE2E94AF2E37247B" modified="2013-07-24" version="1">MEPTIDTVLLATDGSDPAERAAEHAIALAATTEADLHVLAVADAAASRMAEATLGEQGGDSVLNEAAREATGAVADLAADAPASPDVTTIVRTGLAHKEIAAYAQEIDADVTVLGTEGRSGLDRVLLGSVAENVLRTSTRPVLLISPGTPAPDADQTPYDELLFPTDGSEGADRALDWAIGLAAHYAAPLHALFAADASPFPTTVRSKQLLQALESAGNDAIEAVRERGEARDVEVVGAVASGAPGPTILEYCEDEPIDLVVMGTHGRSGLDRYLLGSVTEHVVRHGDVPVFCVPMRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H7</accession>
    <name>R4W9H7_9EURY</name>
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        <submittedName>
            <fullName evidence="1">RecJ-like exonuclease</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_13645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02668.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13645"/>
    <dbReference type="EnsemblBacteria" id="AGN02668">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2792"/>
    <dbReference type="eggNOG" id="arCOG00428">
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    <dbReference type="OrthoDB" id="80989at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="39689" checksum="A3D9D87535EBFDEE" modified="2013-07-24" version="1">MPATSRAATDAPDASDAAASLREAPLARLVVRRDGDAVAAASVLARALRQIDVPVQVSPTATEQARIERVDAGDPKAVTVAIGPVAGADVALGGEDRPVSIATAEIARELGVEPDAELALAGVVAAGELPADVAPALLERAKANGLERRDGVGIATDDLVDGIAHSLAFHATFSGNTEATATALDGIGIDGDVRETVAGDEHRALTDEQRRSIASLVAVAGTESDAPEAAADSIERVIRPHRLAGPVPTLEGYADLLSTTAVVEPGLAVAHAIGDLAVDTLESSWRAASVATHGALADADPARYDGVAVYDAEDASPEIVAALARDALSPEPVALAIGTDAIGLASRDSDAPDLVGALADAAGGDADVTTRYAVVREPTNVTETALVEAIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J9</accession>
    <name>R4W9J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08220</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08220"/>
    <dbReference type="EnsemblBacteria" id="AGN01589">
        <property type="protein sequence ID" value="AGN01589"/>
        <property type="gene ID" value="L593_08220"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08220"/>
    <dbReference type="eggNOG" id="arCOG06395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3323146_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="38" mass="4158" checksum="EA4F9803FF2B595A" modified="2013-07-24" version="1">MMASNNDKTLYQGEVEKEASQVVDQLRLGGINISITGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M5</accession>
    <name>R4W9M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08470"/>
    <dbReference type="EnsemblBacteria" id="AGN01639">
        <property type="protein sequence ID" value="AGN01639"/>
        <property type="gene ID" value="L593_08470"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08470"/>
    <dbReference type="eggNOG" id="arCOG04657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3003058_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="56" mass="6530" checksum="26B7931DC73F179A" modified="2013-07-24" version="1">MSDELELECPECGEERTFWLTARTEVHIGRKRKFRCAECNYGIVRIDHTVDTSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N4</accession>
    <name>R4W9N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447717.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02823">
        <property type="protein sequence ID" value="AGN02823"/>
        <property type="gene ID" value="L593_14420"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14420"/>
    <dbReference type="eggNOG" id="arCOG03924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161782_2_0_2"/>
    <dbReference type="OrthoDB" id="117890at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="87" mass="9706" checksum="647E784C83BBFFBB" modified="2013-07-24" version="1">MRRSRAEWMTPADDQILEVLAEEGAGTPSSLAKTLDYNNNYLTTRCTKMTEYGLLEKPARGLYRITDAGESYLAGNLNAEELESEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P9</accession>
    <name>R4W9P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447762.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14660"/>
    <dbReference type="EnsemblBacteria" id="AGN02868">
        <property type="protein sequence ID" value="AGN02868"/>
        <property type="gene ID" value="L593_14660"/>
    </dbReference>
    <dbReference type="GeneID" id="16181385"/>
    <dbReference type="KEGG" id="sali:L593_14660"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064234_0_0_2"/>
    <dbReference type="OrthoDB" id="112837at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="35581" checksum="CAFC88F2D00CD38C" modified="2013-07-24" version="1">MFADRRIFVLLTAALLVLVPVVGAVGVVTGQDTTRVDEGGTYSGGTVVIEGPIDGDVRVFAGTVIIQGDVDGDVQAFAGTVQVQGTISGNLQAAAGTVVVDGSVRGDVSVAAGTLAIDGSVGGNVRSASGTTQLGERSVVLGDLEYTGDLERLEGSRVLGSVDQRVALQIGPVLVPPLWGWFVTVFAMLAHAALGAVLLLAFPEYSRSVVDRIESDPLVTGAAGLGVFVGVPIVLVLLLLTIVGIPVSIAGLVIFGIVCWIGLVYGRFAVGYVLVRRAGRDSPWLGLGVGLVGVGVLTQLPYVGGLVQFVTLLLGLGALGVSGARELRRRRGEIDSDAEPTAADETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V4</accession>
    <name>R4W9V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446753.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09570"/>
    <dbReference type="EnsemblBacteria" id="AGN01859">
        <property type="protein sequence ID" value="AGN01859"/>
        <property type="gene ID" value="L593_09570"/>
    </dbReference>
    <dbReference type="GeneID" id="16182753"/>
    <dbReference type="KEGG" id="sali:L593_09570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1970"/>
    <dbReference type="eggNOG" id="arCOG02827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301613_0_0_2"/>
    <dbReference type="OrthoDB" id="2763at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="553"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="675"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="730"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="788"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="2">
        <location>
            <begin position="905"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="953" mass="104296" checksum="FA4D0D93CB4C80C3" modified="2013-07-24" version="1">MAASDIQDGKLVELYHRYVGEPDSKRDVYGYWLFLMGTLAGILGFLIYEVGVVMSGQNWALRRIAIVLAASGGVFGLLGIVTLLPVRRRAMQASLVGAAVALLSMPVFWTVYPGSWNVNQGTDYAPIIIAVYSLGVGVVAGVAVLVPVITGEKGLLVEPELGIDSDASPVLLGEEKEDAFFAVFEHPSNDWAWRIIQRDALGESAELAPSDTDARLAIDDVRETIGDAGMLEITTAAFRLYKTDEGGWRWSLVRDDGSVLARSDEPAATRDEAESTVTFLKEAIPGANVIEIRSAAFDVSEDERGDWHWRLLDDRRQPLATDPGGYDDEAAAEVATDQFVEGIDGSRILAFEVGVELVPGDGGWHWRIVDRDDRALVTSEAAYETRRSAEQAASDAAERVGDATIIQRGQPGYELYAVGDGHRWRLRDDADDLIATSHETVDAAGTIQQRAERTRSVVGDAETVEVEGADYEVYPESNPGVAAGGDDAAEAAGDGGRTWNWRLVSADRRLLADSTESFADSEAAESAASRVREQALAADLIEFEQAAFQQYESGGEWRWRLIDEDGQVMADSGEEYGSREEVMDGMTTLKENAPDAEVLEIDTAAFEIYKTDAGEYAWRLIDEAGKLIAEGAETHPSRASARDAVDFLTENLEDARVRGMETAIFQLSTDVEADVWDWWLVDTDGTILAEGTERYPTRDDAVAAIADVREAGDGAEVDQIGALTLQLRNGGGWHWRLIDRDREAVATGDRTYEDRGSALTDAHAVIDGAADAPVFELGDGVIWVDETDDGWGWRLLDANREPVAVSAERYESQHAAVEAVEDVQSRAPDAGTLEFDTLAFELHRDETDGWAWRLLDERERVRAVSAANYEVRDDVTTAIDESKDVVGQASILEIDEAAFEFHERGGGWIWRLVDENGRSLAESVEPHPSRQAAREEMLSVKEHGPEGETVVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W7</accession>
    <name>R4W9W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional D-altronate/D-mannonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446818.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09895"/>
    <dbReference type="EnsemblBacteria" id="AGN01924">
        <property type="protein sequence ID" value="AGN01924"/>
        <property type="gene ID" value="L593_09895"/>
    </dbReference>
    <dbReference type="GeneID" id="16182849"/>
    <dbReference type="KEGG" id="sali:L593_09895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2037"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_6_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034589">
        <property type="entry name" value="D-mannonate_dehydratase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF6">
        <property type="entry name" value="PTHR48080:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41050" checksum="D9C285A18CB1215B" modified="2013-07-24" version="1">MEIRNADVVLTNPGRNYVVVRLETADGLVGWGDATLNGREKAVEAALEEHLFPELEGRDAHRAEDVWQSLYRGTYWRGGPVLQSALSGVDMALWDLKGKAAGLPVHDLLGGRTREYATVYDHCGDDSIDAIVENAEASLDRGIDHFRVNVGDPMGDYLDLDGVVDGVLEVRDRLGPDPELIVDVHSRASPREARQIARGLEPAELFFLEDPLAPEHDAEYGALRNATTTPIAYGELATDPFALQPLIEDGAIDFVRVDLAHVGGITAARKLATVAEGNGTKTAFHGPPDLSPIGQAATVHLDLALPNFGVQELTDYEERYGDAVGEVFAGGANFDPSVGGLDVPDEPGLGIDVDLDAAASFEYERSHLPKRRAEDGSVADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z1</accession>
    <name>R4W9Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446938.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10495"/>
    <dbReference type="EnsemblBacteria" id="AGN02044">
        <property type="protein sequence ID" value="AGN02044"/>
        <property type="gene ID" value="L593_10495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180291"/>
    <dbReference type="KEGG" id="sali:L593_10495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2163"/>
    <dbReference type="eggNOG" id="arCOG00622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982154_0_0_2"/>
    <dbReference type="OrthoDB" id="46801at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016427">
        <property type="entry name" value="UCP004699_CBS/ParB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004699">
        <property type="entry name" value="UCP004699_CBS_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="29415" checksum="00564E7CD431E85A" modified="2013-07-24" version="1">MTVAEGANHARVAAYMTEDVATVDPEETVAAVAERIVESEDHSGFPVAERRQVEGFVSASDLLLAEDDAPIFTVMTTDILVAHPEMKVTDAARVILRSGIQKLPVVDDAGTLVGIISHADVIRSQIERATPEKVGKLRRTLEGIHDVELREERREVALDELIPTQGKVYADELEGRRYELERGLAEPLVVIDDAGTLLLADGHHRVLAADQLGVEEMEAYVIVIDEFVELGMLRTARQEGLERIADIEVVDYARHPLIETTKRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA48</accession>
    <name>R4WA48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G6PDH family F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447223.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11930"/>
    <dbReference type="EnsemblBacteria" id="AGN02329">
        <property type="protein sequence ID" value="AGN02329"/>
        <property type="gene ID" value="L593_11930"/>
    </dbReference>
    <dbReference type="GeneID" id="16182120"/>
    <dbReference type="KEGG" id="sali:L593_11930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2455"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="335" mass="37697" checksum="2988116184231A1F" modified="2013-07-24" version="1">MTKFGWFASLEEFSPQECLDQVDIAYANDFDSITVNDHFHPWFHTGADGEEANCGNCWSWMPIALDRTEDMEIGTGVSALLRRYHPANVAHRLATLEELYPGRVFLGVGTGEALNESPLGNPLPDYGERAKRTAEAIRLIRRMFEEEFVTFDGNFYQTDEAKLYTGPDEAPPIHIAASGPTAARMAGDLGDGLITVYEDPEFIHDTIFAQVRNGVEKSERNEHFDDVEKTIHIHVSLDEDYEAALKPALPWRGTLVERFYTDDVADPRVIQEAGEEEVSEEELTDAYVVTDDPQDVIDVTETYVDCGFEHIVYQSHSPDQEAFAEFVADDVMPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA58</accession>
    <name>R4WA58_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447273.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12180"/>
    <dbReference type="EnsemblBacteria" id="AGN02379">
        <property type="protein sequence ID" value="AGN02379"/>
        <property type="gene ID" value="L593_12180"/>
    </dbReference>
    <dbReference type="GeneID" id="16180411"/>
    <dbReference type="KEGG" id="sali:L593_12180"/>
    <dbReference type="eggNOG" id="arCOG00504">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_1_2"/>
    <dbReference type="OrthoDB" id="103066at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="20689" checksum="37AD070186CDCA77" modified="2013-07-24" version="1">MISNVAAEVQAFTSNAFLVEGERRVLVDTGAGFDVVSVIDAHGGDLDAVVLTHTHPDHIGNAADLRNAYDVPIYGYDTNHDAVDEPLADGDVLQLGDHEYEVLHTPGHAEDHCCFYADATGVLFAGDLVFQNGGYGRTDLPGADRRTLLESIESVLDVIDEDLRELHTGHGPSVTEDAFQHVELAARSARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA64</accession>
    <name>R4WA64_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447303.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12350"/>
    <dbReference type="EnsemblBacteria" id="AGN02409">
        <property type="protein sequence ID" value="AGN02409"/>
        <property type="gene ID" value="L593_12350"/>
    </dbReference>
    <dbReference type="GeneID" id="16179871"/>
    <dbReference type="KEGG" id="sali:L593_12350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2540"/>
    <dbReference type="eggNOG" id="arCOG06400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164491_0_0_2"/>
    <dbReference type="OrthoDB" id="115203at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="98" mass="11062" checksum="EA9DCBA5FAC71F4D" modified="2013-07-24" version="1">MTWGCGIEGCAEVFDSVEDVVVHQTNEHERHECKVCGTVVPDGYLAIKHAFEEHTRAEYVRAYGASAEEVREREQIQDEVEAKADLQTIVDQIDEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA1</accession>
    <name>R4WAA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447488.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02594">
        <property type="protein sequence ID" value="AGN02594"/>
        <property type="gene ID" value="L593_13275"/>
    </dbReference>
    <dbReference type="GeneID" id="16180502"/>
    <dbReference type="KEGG" id="sali:L593_13275"/>
    <dbReference type="eggNOG" id="arCOG04994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691610_0_0_2"/>
    <dbReference type="OrthoDB" id="71571at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="155" mass="17316" checksum="0AB89B9B5FE7CC6A" modified="2013-07-24" version="1">MLACESVQRAIVDCLPADVTCRIGPHGIAELPGEQGQSIRSTIEWWRSHRPREYVDAEVLVCSSAVTWEYGGMVEELGGRVGVASYGDWMEDPRYRRILLHEVGHCLGMRHEHGRRWSTDGESVATAMAPVYPARSPLDYSDEAAAELRRYAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB2</accession>
    <name>R4WAB2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="8" type="ORF">L593_13550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447543.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13550"/>
    <dbReference type="EnsemblBacteria" id="AGN02649">
        <property type="protein sequence ID" value="AGN02649"/>
        <property type="gene ID" value="L593_13550"/>
    </dbReference>
    <dbReference type="GeneID" id="16181368"/>
    <dbReference type="KEGG" id="sali:L593_13550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2774"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OrthoDB" id="99842at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="7">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15186" checksum="2FD5C6CBE1ED29A5" modified="2013-07-24" version="1">MPTRTLTDEARRTLALFEDVTDVSGVDCVIDDEFDRAIILVPATDMAQAIGPGGQNVRAVEEELGRDVKLVEDADTKTDFVANALAPAAVLNVTISENDDIVAYAEVAEADVGVAIGEDGRNIEAARTMARRHFDLADVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC7</accession>
    <name>R4WAC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bifunctional UGMP family protein/serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L593_13925</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447618.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13925"/>
    <dbReference type="EnsemblBacteria" id="AGN02724">
        <property type="protein sequence ID" value="AGN02724"/>
        <property type="gene ID" value="L593_13925"/>
    </dbReference>
    <dbReference type="GeneID" id="16180958"/>
    <dbReference type="KEGG" id="sali:L593_13925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2849"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OrthoDB" id="9881at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="14">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="TsaD" evidence="14">
        <location>
            <begin position="161"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="565" mass="60042" checksum="3B959A0D0C981886" modified="2013-07-24" version="1">MRVLGIEGTAWAASAALYDTEDDSFFVETDAYVPESGGIDPRESADHMADAIPEVVAVVLDEARDRVATDAAEAGSAEPPIDAVAFSRGPGLGPCLRIAGTAARAVAHTLDVPLVGVNHMVAHLEIGRHRSGFDAPVCLNASGANAHVLGFHRSRSNTARSASSNERIESDGGRYRVLGETMDTGVGNALDKVARHAGLSHPGGPKLEELAADGDLIDLPYVVKGMDFSFAGIVTAAQDALDDGAAIEDVACSLQETIFAMLTEVAERALSLTGSDELVLGGGVANNARLREMLQGMCEERGAACFMPESRFLGDNAAMIALTGSKMLAAGDTLPIEDSGVRPDYRPDQVPVTWRDGDSSTAVVPAEERERRGAEAVVEVGEDRVVKRRVPKGYRHPDLDDRLRRERTRSEAKLTARARRLGVPAPVVLDVDPVEATIELTRVGDRDLQADLDPALLEQVGTHLATLHADGVVHGDPTTRNVRIVDADVESASDTSVALIDFGLGYDSDHVEDKAMDLHVLEQALDGTADDAVACRDALETAYADAGDPAVLDRLREIEGRGRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VRY0</accession>
    <name>R4VRY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444854.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00025"/>
    <dbReference type="EnsemblBacteria" id="AGM99959">
        <property type="protein sequence ID" value="AGM99959"/>
        <property type="gene ID" value="L593_00025"/>
    </dbReference>
    <dbReference type="GeneID" id="16180599"/>
    <dbReference type="KEGG" id="sali:L593_00025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.5"/>
    <dbReference type="eggNOG" id="arCOG04644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709049_0_0_2"/>
    <dbReference type="OrthoDB" id="37381at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041346">
        <property type="entry name" value="DR2241_Fer4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041181">
        <property type="entry name" value="DR2241_middle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18069">
        <property type="entry name" value="DR2241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18009">
        <property type="entry name" value="Fer4_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DR2241" evidence="3">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fer4_23" evidence="2">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGM99959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="373" mass="42208" checksum="695593F3811EE1D2" modified="2013-07-24" version="1">MDDALVDALLVAAEDGGVDCDGLVATVDDSDGYVFAAGDERHHGVDEERFRELAREHPRYVGNWRFWAQETPPGDDRVAFLRWLEGAEDEPLPDRLNRLEDGVETTWGQLHVTVTLADSGAAAPASQYHRQYTLRHAEDVHGEAPVDSADLTDHTDPLDARELSKHDDRNRYRPLKTAPTLQRGWRFPDLDPSALVRAVECFYPATIPNWHREREGDLDVDHWRDTAERQTGIYDVVEELPREAVEWVAEACCVDSQCTKRREWQYDEGEALEADGGDGTYPCREPCSLVVAAARKWTILEGETERTYEFDLTPSEKHQLEELIDAVADGRVDEIREADVGDGANRYRARYLRAKRFDDEGNLCGVPTTDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VRY5</accession>
    <name>R4VRY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444859.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00050"/>
    <dbReference type="EnsemblBacteria" id="AGM99964">
        <property type="protein sequence ID" value="AGM99964"/>
        <property type="gene ID" value="L593_00050"/>
    </dbReference>
    <dbReference type="GeneID" id="16180765"/>
    <dbReference type="KEGG" id="sali:L593_00050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.10"/>
    <dbReference type="eggNOG" id="arCOG01067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_2_2"/>
    <dbReference type="OrthoDB" id="29466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGM99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="385" mass="41253" checksum="83EE0E70EC55BA90" modified="2013-07-24" version="1">MSPTVAVLGAGYAGAGAVQRLESELGDDADLVWISDTDYHLVLHESHRCIRDPSVRDSITFPVEEIKAPSTTFVHSEVTGLDAEAQTIELADADDVDYDYVLVAIGSATAFYGIPGLAEHSHTLKSLDDALSIHEALVAAAKEATRSNPATVVIGGAGLSGIQTAGEVAEYRDEHDAPIDIVLVEALDEIFPGQDPSIQQALRKRLEARDIEIMTGDPITEATEEAVIFEDADDLHFDVLVWTGGISGRDALEDSGLDNEHNRLSADDTFQTSDDRVFAIGDSALVAQNGDVAPPTAQAAWQAAEVAGQNLARAIEGRSLKSWRHDDKGTVVSVGEDAVAHDVDVVPFVDTFGSVPARLLKKAIAARWIKDISSWRRAKTAWPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS88</accession>
    <name>R4VS88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SOUL heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444979.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00085">
        <property type="protein sequence ID" value="AGN00085"/>
        <property type="gene ID" value="L593_00650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181884"/>
    <dbReference type="KEGG" id="sali:L593_00650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.132"/>
    <dbReference type="eggNOG" id="arCOG04820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068699_0_1_2"/>
    <dbReference type="OrthoDB" id="96329at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_haem-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="PTHR11220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="23547" checksum="5BBCC84EC51A070C" modified="2013-07-24" version="1">MRSSTKAALVGGAVFLAGWIGWGRHSGNNVETVPYDRVRTIDSVEIRRYPQVVLAETTAPNEITAFRRLFRYIAGANRGDVEIPMTAPVETQSGESMSMTTPVRSESDAASEEVRMAFYLPTEYDHETAPEPTDPTVALVTEPAKTVAVDSFSWYAPKWRIERRERRLLDALERDGIRPFGEPYLLRYDDPWTPPFMRHNEVAVVVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VST9</accession>
    <name>R4VST9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445139.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01460"/>
    <dbReference type="EnsemblBacteria" id="AGN00245">
        <property type="protein sequence ID" value="AGN00245"/>
        <property type="gene ID" value="L593_01460"/>
    </dbReference>
    <dbReference type="GeneID" id="16179816"/>
    <dbReference type="KEGG" id="sali:L593_01460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.297"/>
    <dbReference type="eggNOG" id="arCOG03919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059308_0_0_2"/>
    <dbReference type="OrthoDB" id="103559at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="32087" checksum="5F027D2F62E84D66" modified="2013-07-24" version="1">MIHVDAPGVLAGAIVLGLVHGVEPGHGWPVAAAYAMDRSNTWGAGLAASLLLGVGHLISSIAVVVAYFFAIAYFDLTSLDEPIVVAGVQVGGPLGIVAGILLIGLGIREYYGGGHGHAHGSSEPHDEHSHGGGHSRGNAHAHDSGHSHGDDHSHQHGQAHEDDHVHEHGHAHADDHSHDHHEDGDPSGVLGRLRGALPIGGGGHEHLDESTAHDRGLMGIAWVAFVLGFAHEEEFEIIALCTGSAHCLELMLAYALTVIFGIVALTMALLAGYQHFEDRVETITPYLPAFSAIVLVVMGLGFLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSX6</accession>
    <name>R4VSX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deacetylase, histone deacetylase/acetoin utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445184.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01685"/>
    <dbReference type="EnsemblBacteria" id="AGN00290">
        <property type="protein sequence ID" value="AGN00290"/>
        <property type="gene ID" value="L593_01685"/>
    </dbReference>
    <dbReference type="GeneID" id="16180024"/>
    <dbReference type="KEGG" id="sali:L593_01685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.342"/>
    <dbReference type="eggNOG" id="arCOG00324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_2_2"/>
    <dbReference type="OrthoDB" id="34461at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="337" mass="36160" checksum="4F5181BF429530AC" modified="2013-07-24" version="1">MQFGYSDLCLEHDPGRRHPESPDRLRAIREGLKRQHGVEYVDADPIDLDAVRELHDPDYVEELQSFCEDGGGEWDPDTVVVHGTWDAILKSAGLARWAAERVMAGDDGRDTPFSIGRPPGHHAVADDAMGFCFVNNAGIAAQTALEAGADRVAILDWDVHHGNGTQDLFYDRDDVFFASIHEEGIYPGTGDSNETGTGAGAGATLNVPMPPGAGDAAYGLAIESLVRPALERVEPDCFLISAGFDAHRHDPISRMSVSTEGYGWLATLARSIADDVGAGLGFVLEGGYGLDVLAESVRTVHEVCDGYQPVEPDEEPSEAVRSRIDAIATAHQAVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT43</accession>
    <name>R4VT43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445264.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00370">
        <property type="protein sequence ID" value="AGN00370"/>
        <property type="gene ID" value="L593_02095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182422"/>
    <dbReference type="KEGG" id="sali:L593_02095"/>
    <dbReference type="eggNOG" id="arCOG04682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_1_2"/>
    <dbReference type="OrthoDB" id="41970at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="31058" checksum="1A9EBAF4230BA5D8" modified="2013-07-24" version="1">MVNDTTAGEVAGWADSRITAVIELDGGEVGSVHRVDLADDRRVVVKTADTDLRTEAKMLAHLRSEGGLRVPDVYHVTPDLLVMEFVAGESTVTPAVERDLADRLAALHATEADQFGFPFDTLTGAYRQPNPWTDGWATFFGDERLGYAASRAREDGELPPDLAERIDDLAADLPALLDHDPTPSLVHGDVWSANVLTGGESVQVFLDPACYYADPEVELAYAEWTEVAGDAFFERYRERAGADSGYDDRKHVYQLYPLVTHVRHFGEAYLEPLEATLDTLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT85</accession>
    <name>R4VT85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445314.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02345"/>
    <dbReference type="EnsemblBacteria" id="AGN00420">
        <property type="protein sequence ID" value="AGN00420"/>
        <property type="gene ID" value="L593_02345"/>
    </dbReference>
    <dbReference type="GeneID" id="16180177"/>
    <dbReference type="KEGG" id="sali:L593_02345"/>
    <dbReference type="eggNOG" id="arCOG02394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063179_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007381">
        <property type="entry name" value="CheF1/F2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42201">
        <property type="entry name" value="PTHR42201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04283">
        <property type="entry name" value="CheF-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="32308" checksum="72935A406797B8DF" modified="2013-07-24" version="1">MVADFVAEAIYAGVEGDEPTQARVLLSEDQLVLAGDGGRTSIDLDDVFDVVVSKIPDDLGSFLDQSVLVAYAADGERRTAVIRGDHERIDRFSLFLHKAILRSEPAELRHPIREGGRVRDPAPQTVAVLPGEDAVRFRSQETDLNVALDDVVEIDYRQGNGGDRPTLVVRHRDGDDVVTSEIVQDDANRLNVLTRHLRSEYYRADEVLQELDLERVEQRALVALYAGVAPDALGAVLDTDDGDDGRSGGLGESSRQPVDPESVLAGLVDRELVTDDGTLTHDGALVAIHRIDEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTF4</accession>
    <name>R4VTF4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thymidylate synthase</fullName>
            <shortName evidence="4">TS</shortName>
            <shortName evidence="4">TSase</shortName>
            <ecNumber evidence="1 4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thyA</name>
        <name evidence="7" type="ORF">L593_02745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445394.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02745"/>
    <dbReference type="EnsemblBacteria" id="AGN00500">
        <property type="protein sequence ID" value="AGN00500"/>
        <property type="gene ID" value="L593_02745"/>
    </dbReference>
    <dbReference type="GeneID" id="16182408"/>
    <dbReference type="KEGG" id="sali:L593_02745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.556"/>
    <dbReference type="eggNOG" id="arCOG03214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_0_2"/>
    <dbReference type="OrthoDB" id="32556at2157"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="6">
        <location>
            <begin position="2"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="41514" checksum="AD4E348DAC35AEA8" modified="2013-07-24" version="1">MQQYLDLVAGVLGEGTYKPNRTGVDTIAGFSRHYEVDLQEGYPLLTTKQMDGFRWNSMLHEVLWYLSGQEHIRELREETGIWNDWADEDGHLDTAYGRFWRRYPIPEAGQQLPGESWPDDAHRWVSVEEVETDDGTDAGEGSTTERRVFDQIQYVLDSLEENPNTRRLVVNAWHPANAAVSTLPPCHYTFVFNVQGDRLNCHLTQRSGDVALGIPFNVAAYSLLTEAIAQRTGFEPGTFSHTIVDAHVYCGSGDRGAWYQENLEELQERLAAVEARGDPEEPRGADRQVSEGYREVREWILRNAPDEAEGDEGSDHVPELLTQLTREPRERPEIEIADVPLDELTFEDIELRNYGAHPGLSFAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTR5</accession>
    <name>R4VTR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445519.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03370"/>
    <dbReference type="EnsemblBacteria" id="AGN00625">
        <property type="protein sequence ID" value="AGN00625"/>
        <property type="gene ID" value="L593_03370"/>
    </dbReference>
    <dbReference type="GeneID" id="16179825"/>
    <dbReference type="KEGG" id="sali:L593_03370"/>
    <dbReference type="eggNOG" id="arCOG02327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA_7TM"/>
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    </dbReference>
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        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="359"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="574" mass="61325" checksum="FA22AD049BAFD271" modified="2013-07-24" version="1">MPVSPLVVLSLLSGVLCLVSGWLVRGRWAKPGALWFQIGALASACWSIGYGVGLLVFDSRLRQLFEIPIWLGHGVGPVAFFLFVAAYTGRRTILDRPIVAGLFVVPAITMVAVLTSGEHALMWTDYRIDAALGAATVTYEKQPWLYVHKAYSYAVLLAAGAILLAVLVDRDALYTIQATLLMGVVVSLGAGSLAWVIGIGPYPQVTTTPLLFGWVFAIAAAVFFRAPLFDSPPAARRLGRERLLSEFGDGVVVVDDEGRIVEANPAAIALLGSAADDDLVGRSIDEIGGVPADSAESSIPLEQGRHRVELQTASGRQPFEITISPVRDESGSLLGRTLVFQDVSEETRRRQQLSVLNRVLRHNLRNDMTVVRAFAEELADSAPDERRADMAETILEEADGLLSLGEQARTIEESLADPDRPVEPIELEPIVDDVVEPYRDSAEVTVDVPEGYVLETDPRSLAAVLTAAVDNAVEHSSADRPAVTIAANHDAGRARITVSDDGPGIPDHELEPIRAGTETDLEHGSGLGLWLITWGAGSLGGEVSFHTGDDAGPGDGGTTIELELPGTDTSEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUU0</accession>
    <name>R4VUU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00380"/>
    <dbReference type="EnsemblBacteria" id="AGN00031">
        <property type="protein sequence ID" value="AGN00031"/>
        <property type="gene ID" value="L593_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00380"/>
    <dbReference type="eggNOG" id="arCOG00514">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124266_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15820" checksum="A5E25F2BB12CCE4D" modified="2013-07-24" version="1">MDEDTVASYLERQETGVLSLADDGDAYAVPIAHYYDDGNLYFRLGRTEDSQKWEAIEATDTAAYVCYGTAETTDPRELESWSVLASGPLRELPPEEAERFDAAEINEHFPPIRVFGESIDEVDVVILELEVESVIGRTTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ4</accession>
    <name>R4VUZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Monovalent cation/H+ antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_00705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444990.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00705"/>
    <dbReference type="EnsemblBacteria" id="AGN00096">
        <property type="protein sequence ID" value="AGN00096"/>
        <property type="gene ID" value="L593_00705"/>
    </dbReference>
    <dbReference type="GeneID" id="16181932"/>
    <dbReference type="KEGG" id="sali:L593_00705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.143"/>
    <dbReference type="eggNOG" id="arCOG03078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102546_0_0_2"/>
    <dbReference type="OrthoDB" id="64692at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
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        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19023" checksum="A08A1907725867A2" modified="2013-07-24" version="1">MTPGALELALFGFVLGTALATAAFKDVLAAIIVFAAYSLGMAIYYAVLLAPDVAMTEAAIGAGVTTLLLLLTIAKTVRPGREKLLEEVHLPGLLIVGTFTGAILVTVTSFPAIGATDAPIWSNPEVSQYYLEEAYHDTGVENVVTAVLAGYRGFDTFGEAVVVFAAGVASLVVLHSEVFTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVI3</accession>
    <name>R4VVI3_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445150.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01515"/>
    <dbReference type="EnsemblBacteria" id="AGN00256">
        <property type="protein sequence ID" value="AGN00256"/>
        <property type="gene ID" value="L593_01515"/>
    </dbReference>
    <dbReference type="GeneID" id="16181608"/>
    <dbReference type="KEGG" id="sali:L593_01515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.308"/>
    <dbReference type="eggNOG" id="arCOG00760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044864_2_1_2"/>
    <dbReference type="OrthoDB" id="60831at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="31230" checksum="2B97EEF7ADC81081" modified="2013-07-24" version="1">MPRRSVLFTPGDRREMLVGAADSDADALVFDLEDGVAPARKSEARETVRSVLADDAFAPDAECFVRVNPIEFERGSGPNGQGAVREDLREIAAAADAIDGIVLPKTSDAGDVRRLGGLLRTHGLPRSILALVETAAGVQEAPGIASAGGTTGLVLGTEDLAADVGASPSADRTESRYARQRVVTAAAAAGVDAIDTLWTDFEDEAGLRDDAADAVRLGFDGKLAIHPAQVGPINEAFTPDETQRDWADRVLAAREEAGDRGAFAVDGEMIDAPLLARAERIAERARAAGFDSVGAATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVJ3</accession>
    <name>R4VVJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446109.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06340"/>
    <dbReference type="EnsemblBacteria" id="AGN01215">
        <property type="protein sequence ID" value="AGN01215"/>
        <property type="gene ID" value="L593_06340"/>
    </dbReference>
    <dbReference type="GeneID" id="16181729"/>
    <dbReference type="KEGG" id="sali:L593_06340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1293"/>
    <dbReference type="eggNOG" id="arCOG05220">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1405956_0_0_2"/>
    <dbReference type="OrthoDB" id="102650at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014858">
        <property type="entry name" value="BrxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08747">
        <property type="entry name" value="DUF1788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="23125" checksum="E4E54F8B906549CD" modified="2013-07-24" version="1">MSDSSSSPLRAFKDRLCTFAEGQHGIRNPFVIVAVDPPVEHRTTKRLEEWATGGSEAPAIPDEVTVQPIWLDELLPRTDVYNLLVDLGESLTELEGDASAGERITETMQDQLATELVEEMIEEELSEEQLTSQQHVVLLLNLGSLYPFTRASELLDELDRRNVKSTIGIPFPGDVIGGKLSFFGGDSRHYYPAHQIDRPITEVHLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVN1</accession>
    <name>R4VVN1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="17" type="ORF">L593_01800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445205.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01800"/>
    <dbReference type="EnsemblBacteria" id="AGN00311">
        <property type="protein sequence ID" value="AGN00311"/>
        <property type="gene ID" value="L593_01800"/>
    </dbReference>
    <dbReference type="GeneID" id="16179951"/>
    <dbReference type="KEGG" id="sali:L593_01800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.365"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OrthoDB" id="6736at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005726">
        <property type="entry name" value="ATP_synth_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01043">
        <property type="entry name" value="ATP_syn_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="15">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="16">
        <location>
            <begin position="93"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="14">
        <location>
            <begin position="219"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGN00311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="589" mass="64972" checksum="4E3DA924C6FB0076" modified="2013-07-24" version="1">MSTTTDTDTVREDGQIESVSGPVVTATGLEARMNDVVYVGTEGLMGEVIEIEGDVTTIQVYEETSGVAPGEPVENTGAPLSVDLGPGLLDTIYDGVQRPLDELEHLMGSAFLDRGVDAPGIDLDRTWEFTPVVEEGDAVEPGDVLGTVPETESIEHKVLVPPRSEGGEVVSAKSGSFDVEETVVELDTGEEISMRQEWPVRRQRPAEEKRTPREPLVSGQRIQDGLFPLAKGGTAAIPGPFGSGKTVTQQQLAKWADADIVVYIGCGERGNEMTEVIEDFPDLQDPKTGKPLMARTCLIANTSNMPVAARESCIYTGITIAEYYRDMGYDVALMADSTSRWAEAMREISSRLEEMPGEEGYPAYLAARLAEFYERAGKFETIGGREGSISAIGAVSPPGGDFSEPVTQNTLRIVKTFWALDADLAERRHFPAINWNESYSLYRNQLDDWFVENVDENWPDVRQWAIDTLDEEDELQEIVQLVGRDALPEDQQLTLEVARYLREAFLQQNALHDVDTFCPPEKTFRILEGIKAFNDEAFEALDAGVPVDEITEIDAVNRLNRIGTTPDDEADEFVSEIEDDIAAELRELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVT0</accession>
    <name>R4VVT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446204.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06815"/>
    <dbReference type="EnsemblBacteria" id="AGN01310">
        <property type="protein sequence ID" value="AGN01310"/>
        <property type="gene ID" value="L593_06815"/>
    </dbReference>
    <dbReference type="GeneID" id="16181891"/>
    <dbReference type="KEGG" id="sali:L593_06815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1392"/>
    <dbReference type="eggNOG" id="arCOG00924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="55756at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="237" mass="25506" checksum="D9A33C2B3954366B" modified="2013-07-24" version="1">MAANGLLTVSDLDAGYGDLQILDSVDLDVDDGEYVTIVGPNGAGKSTVMKTVFGLTTYMGGSVEFDGEEISGLRPDQIIRKGVGYVPQSNNVFGSLSVRENLEMGAYILDSIPAERIQAVYDRFPVLEERAGQTAGSMSGGQQQMVAMGRALMLDPDLLLLDEPSAGLAPDLVDDLFDRVDQINDDGTAILMVEQNAKEALRRCDRGYVLVQGQNRHEDSGEALLADQQVREDFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW73</accession>
    <name>R4VW73_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445415.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02850"/>
    <dbReference type="EnsemblBacteria" id="AGN00521">
        <property type="protein sequence ID" value="AGN00521"/>
        <property type="gene ID" value="L593_02850"/>
    </dbReference>
    <dbReference type="GeneID" id="16180354"/>
    <dbReference type="KEGG" id="sali:L593_02850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.576"/>
    <dbReference type="eggNOG" id="arCOG01164">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_7_1_2"/>
    <dbReference type="OrthoDB" id="33452at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="29"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="46186" checksum="EA4A377A579E24D6" modified="2013-07-24" version="1">MSYDKIEVPAEGEQIQAGDDGLEVPDNPIIPIIHGDGIGQDVGPAAQKVLEAAANATGRDVSWMRVYAGQSARDKYGDDVNLPDETVDAIREHRVAIKGPLTTPVGAGFRSLNVALRQTLDLFANVRPTYYLDGVPSPMKAPEEMDMVTFRENTEDVYAGIEWEQGTDDVEAVRDFVEDEMGMDDIMHEGPIGLGLKPISEKGSKRLVREAIDYALENDRDKVTLVHKGNIMKFTEGQFGTWGMEVADEEYPDDEVFAAPDSLWEEQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDVLAMPNLNGDYLSDAAGAQIGGLGIAPGGNFGEQRMLAEPVHGSAPKRAGQNMANPTALILSGRLMFEYIGWQDAADLIRDAVEQTISSGTVTYDLERQLEGAEKLGTDEYADEIVSAIEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWN2</accession>
    <name>R4VWN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445580.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03675"/>
    <dbReference type="EnsemblBacteria" id="AGN00686">
        <property type="protein sequence ID" value="AGN00686"/>
        <property type="gene ID" value="L593_03675"/>
    </dbReference>
    <dbReference type="GeneID" id="16180649"/>
    <dbReference type="KEGG" id="sali:L593_03675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.746"/>
    <dbReference type="eggNOG" id="arCOG01680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_2"/>
    <dbReference type="OrthoDB" id="111287at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="13348" checksum="1775086ADF097087" modified="2013-07-24" version="1">MASDDATATGADPRSEPCCTPPGSVDEDAVLADVQLLSAAGNDTRYELLRRIAGAETDVCVCDLEAAVGVSQSAVSQALSRLSAAGLVTRRKEGSWRYYGTTPVAEALLDTLDDLRAATEPDEVASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWN6</accession>
    <name>R4VWN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445585.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03700"/>
    <dbReference type="EnsemblBacteria" id="AGN00691">
        <property type="protein sequence ID" value="AGN00691"/>
        <property type="gene ID" value="L593_03700"/>
    </dbReference>
    <dbReference type="GeneID" id="16180666"/>
    <dbReference type="KEGG" id="sali:L593_03700"/>
    <dbReference type="eggNOG" id="arCOG09006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923218_0_0_2"/>
    <dbReference type="OrthoDB" id="80740at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="275" mass="28122" checksum="EA2B62055905FC73" modified="2013-07-24" version="1">MGPVDRVFVVVDRELRTLVRNRALVAVAVAFFAVVVGLGALSRDAAGGYVSLTYDLLLVVEVLVPTIAFAFVFRSIRGDDERGELDVIRTYPITRLEYVLGVFVGRVLGLLVVVLAAFGIAGALASGSGGAPQTFLATHDAGDTVLVYVRFVLLTAIYTLVVAALALAVSAGTRTTRGALAAAIGGVLVIAIGLDLALLTLVSSGAIGGNAIALFEGLSPASAFRGLVFELALGPALASEPGDGMASPLVASLSLLVWLALGLGMATVAVWQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWW3</accession>
    <name>R4VWW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03975"/>
    <dbReference type="EnsemblBacteria" id="AGN00746">
        <property type="protein sequence ID" value="AGN00746"/>
        <property type="gene ID" value="L593_03975"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.808"/>
    <dbReference type="eggNOG" id="arCOG00619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="40434" checksum="423717B88C674CAC" modified="2013-07-24" version="1">MQGLADVTPDLPVRYEDLEATALDALDDGAAGYVAGGAGGEETMDANREAFTEWRIVPRMLRDVEDRDLSVEVLGQEFAAPVLLAPIGVLSIVHEDAEIAVAEAAADLDLPMCLSTVSSFRLEQVAETLSHEDGRGWFQLYWSSDRAVTESLVERAEDAGFEALVVTLDTPLLSWRERDIEEAYLPFLDGEGLANYFADPAFLDRLDVDPAENELAAIREFVDVFGDPSLTWDDLELLVGETDLPVVVKGILHPDDAAEAVDRGADGVIVSNHGGRQVDRAVPALEMLPEVVDRIGEDASVLFDSGIRRGSDAIVALALGADAVMLGRPYVYGLALDGADGVRAVGQNFLADLDLTLGLAGQSSIEGLDRSVLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWW8</accession>
    <name>R4VWW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_04000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445645.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04000"/>
    <dbReference type="EnsemblBacteria" id="AGN00751">
        <property type="protein sequence ID" value="AGN00751"/>
        <property type="gene ID" value="L593_04000"/>
    </dbReference>
    <dbReference type="GeneID" id="16180782"/>
    <dbReference type="KEGG" id="sali:L593_04000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.813"/>
    <dbReference type="eggNOG" id="arCOG01111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="SSF52009"/>
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        <property type="entry name" value="PEP_ENZYMES_2"/>
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        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="10">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
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        <location>
            <begin position="430"/>
            <end position="501"/>
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            <end position="834"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="333"/>
            <end position="395"/>
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        <location>
            <begin position="513"/>
            <end position="547"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="333"/>
            <end position="365"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001518"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
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            <dbReference type="ARBA" id="ARBA00004742"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
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            <dbReference type="Pfam" id="PF01326"/>
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        <source>
            <dbReference type="EMBL" id="AGN00751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="847" mass="89178" checksum="24913705858864EA" modified="2013-07-24" version="1">MGLRWLDDVRADDGASVGGKGASLGELTAAGLPVPPGFVVTADTYRSFLQAADLEADLDAAVSVDADDPSELAGAAERAQTMIRDASVPDSFREELLGAYDDLGAGMASEPFVAVRSSATAEDQPDASFAGQQETFLNVDRDGLLEAVRECWASLFTQRAIYYRQQQGYPASDVDIAVVVQLMVDADASGVMFTSHPSTGDGRMILEAAWGLGEAVVAGEVSPDNYVVDRERETVSDVAVADKRIQYVRDPDTGETIEEPVPDDRREQRVLDEEALDRLREIGERVESHYGTPQDVEWALVQHEAGQAPVSGVDAGAGLDDATVYLLQSRPITTLPDDATPTDTASDVRSETAAETASNAASAGGPDPTTAVGDQDGDPERSTESDAASADGGSQAMASEELLVTGLGASPGTAAGPARIVEKLDELDKVEAGDVIVTKMTTPDMVPAMQRASGIVTDEGGMTSHASIVSRELGVPAVVGTGSATNEIEDGQAIAIDGETGRVTTGDEAEFQAGEADTPDSGSGAESAGPSATATAAGAGSQATDRVPPATATEVKVNVSIPEAAERAAATGADGVGLLRMEHVVLSTGQTPEHMIARDGEDAFVDVVADGIQPVAEAFYPRPVRVRTLDAPTDEFRTLEGGADEPEEHNPMLGYRGIRRSLDRTDPFRAELAAVAKCHELGYDNVELMLPLVTDAEDVRAAKEHMRAAGLDPRHTTWGVMVETPASALCVEGICEEGVDFVSFGTNDLTQYTLAVDRNNERVADRFDELHPAVLELIGDVIETCRAHDVRTSICGQAGSKPAMVRHLVDAGITSISANVDAVADVQREVERVEQRLLLESVREEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXG8</accession>
    <name>R4VXG8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nmad3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446839.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10000"/>
    <dbReference type="EnsemblBacteria" id="AGN01945">
        <property type="protein sequence ID" value="AGN01945"/>
        <property type="gene ID" value="L593_10000"/>
    </dbReference>
    <dbReference type="GeneID" id="16181268"/>
    <dbReference type="KEGG" id="sali:L593_10000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2060"/>
    <dbReference type="eggNOG" id="arCOG07784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076080_0_0_2"/>
    <dbReference type="OrthoDB" id="48382at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041135">
        <property type="entry name" value="Nmad3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18754">
        <property type="entry name" value="Nmad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmad3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="270" mass="28240" checksum="E1B4CAAE66418564" modified="2013-07-24" version="1">MPRAVAINVGANSSLPGFRGPVNPDGSAVYVPIPEREPIAADATVPTYADLGLPVEIPDAHRDTDLHLDPSFAEYPHCSDYTYGDEHGVKAAPLLDLDAGDLVLFYATLRTVEHGAGEAEPPGSMPGVIAPPTPSSATESNGAGPRCADPADWRPPKWGAFVIGAFGLDRDPVSGEAFDELPAADRERLAENAHRKRAEPDGAVYLLGDPERSGLLDPVIPLSKPSGGAEANDVVTALSADSGKGPWWRRPLRFDAGATASLAPTIDASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXP1</accession>
    <name>R4VXP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cationic amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445925.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05410"/>
    <dbReference type="EnsemblBacteria" id="AGN01031">
        <property type="protein sequence ID" value="AGN01031"/>
        <property type="gene ID" value="L593_05410"/>
    </dbReference>
    <dbReference type="GeneID" id="16181926"/>
    <dbReference type="KEGG" id="sali:L593_05410"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1105"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_8_2"/>
    <dbReference type="OrthoDB" id="2786at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="482"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="632"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="776" mass="81728" checksum="65375AE5A7DF94BF" modified="2013-07-24" version="1">MSEADQELARDLGFLEAYTIGLGTMIGAGIFVLPSIAAEQAGPASMVSFFAGGLVSLLAALSLSELATGMPKAGGSYYYVNRALGPFFGSIVGWGMWAGLTFASAFYMIGFGQYLLPGLGQYVGFLAGWGELGITVAALVMAALLTAVNYYGVKETGALQNVIVLTLVGLIFAFLALGFISGPSYQEFNPNGWPAVAATIGTVYVTFIGFEVIATSAEEIKNPSRNLPLAMIAAVVTPTLMYVGVMFVATGTLSIDALSSSQIPVADVAENIFSPLATGVSRIPFVDISPSAAESFGALLMIVGAVLATVSSANASILSAARVNFAMGRDRILVDWLNEVHERFRTPYRAITATGIITLLLIAVGVGIDTLAEVASFMYLVTYALVHVAVVVLRRADPEAYDPAFKIPRLLYPIVPIVGFVACLAILVQMSVVVQAIGAVIVAFGVVWYFVYASDRAPSRSLVGDAIAPEPTAVGDGTGRYRVVVPIANPETERDLLRMAAASAHAHEDEQAELIAVNVIEVPRQTSLSQDLAFEEERVQRQQELLETARDIAADLDVGLQTRAIVGRNAGSVILDVIEEENADHVLLGWQGTQSRREHVLGSTIDPVVGRAPCDTTLVKLGPEGGRGRGDIMVLAGEGPHASVAARRAAEFAAAAEDASLTLLNVQSPAEDEAESPTDRGEAIIDDVIEAADIADATVRTEVIVAEDTERAIIDAADEYDTVCVGATRSGAVSQAVFGSLPETIGANVNRTVVMARGQERSPTSIRQAISQRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXY6</accession>
    <name>R4VXY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_05885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446020.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05885"/>
    <dbReference type="EnsemblBacteria" id="AGN01126">
        <property type="protein sequence ID" value="AGN01126"/>
        <property type="gene ID" value="L593_05885"/>
    </dbReference>
    <dbReference type="GeneID" id="16181521"/>
    <dbReference type="KEGG" id="sali:L593_05885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1205"/>
    <dbReference type="eggNOG" id="arCOG02322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_2"/>
    <dbReference type="OrthoDB" id="4671at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="395"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="457"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="352"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="934" mass="99863" checksum="B975ED2803873473" modified="2013-07-24" version="1">MTPKLTSYLLPSFIQRRYTAKFVVSILFVVLAIGIVGYVGYAQVNTTIEDSRQDTLRSSAEMQADSLDEWSQLMEQQSRAIGNLENVANGDGEAITSYEAHLDDYVAIHVIDFSNDTVVFSTVDTIEGNDFESVDDPWASESLQEEFFGGTMWMSEGSYESNALSGTQAIAFATPTSTNSERVVVIDAAIQTRIDQLTQQHSTQSTDIVNADYQYVLSQNSETADGTIDDQNQREAIDAALETRNVQFTSNGGELRAYAPVNGPGTADDWVAVTSIPKSDAYVVRDTVGQSVLMILAVAFLSLGIMGFVLGRQTVTPLRRLQSKAQSMEEGKLDVDLETGRKDEIGQLYSAFDDMRRSLREQIQEAQSAREEAEAERERIQRINMELESTADDYSTVMQQAADGDLTARMETSTDNDAMAAIAEEYNEMLAEIEETVEGLNAFAAEVATASEQVTASSEEVRSASEQISDSVQEISAGAERQNDSLQTVNQEMSDLSTTTEEIAASSNEVADIAEQTAETGRAGRDAAQAAIASMREIEDESSRAVEEIAQLEQEVSQIDELIERIQEISDQTNMLALNANIEASRTTGGEEDGGFGVVAQEVKELSQDAKDAAEEIEHRLESIREQTQRSAEEVEQTSEDVDEASTQVANAVEALEEIAEYAGETNTGVQEISAATEEQAATTEEVVAMVDEAATISEETTAESESVAAAAEEQTTALTEVSSSASDLSEQAARLSEALDRFDTDAEVEGAETRMLEGEALEGTGEGEEPAGEADDDGVDDDVDAFDHDVAVEDFGADAATEPEGGADEPAASPAAEPADEARGDEDVGTATDQTDEATDQTGEDVFDFGQAERSDAGSDPGEDDGAGDDSADVAEGALTDVSGVGDAKAEALRAAGYETVADLRAATQAQLAQVEGIGDALAVEIKEAVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY76</accession>
    <name>R4VY76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02195">
        <property type="protein sequence ID" value="AGN02195"/>
        <property type="gene ID" value="L593_11250"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2320"/>
    <dbReference type="eggNOG" id="arCOG02775">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097789_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="25080" checksum="0A9A3548D4BD8EA0" modified="2013-07-24" version="1">MTDEPPSPDGPDEFPTDEELPDETVTVDDITPFTVDDDDFEDIDEFAAAEWKNETTADERIRTVINRTTVLKSAGDIAETALVSETKARATLNKLAEEGIVSSQQTDSGKLYARDPEWHLLKQIRQLAGSETLVDQIQRVKQEIAAYNAKYDATDPAELLVSDTELDQDELDDVSHWRTAERELGHLRAAYRFKEAKETAATVTEPGDKQTGNQTTTPGGNQPSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYD6</accession>
    <name>R4VYD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447164.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11635"/>
    <dbReference type="EnsemblBacteria" id="AGN02270">
        <property type="protein sequence ID" value="AGN02270"/>
        <property type="gene ID" value="L593_11635"/>
    </dbReference>
    <dbReference type="GeneID" id="16179891"/>
    <dbReference type="KEGG" id="sali:L593_11635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2398"/>
    <dbReference type="eggNOG" id="arCOG06429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047037_2_0_2"/>
    <dbReference type="OrthoDB" id="74213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="PTHR17985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="27584" checksum="9B82BEF5491D999B" modified="2013-07-24" version="1">MCTIAFAWQVLDDAPIAVAANRDEALDRESHPPRVLESDPTVLAPQDAEAGGTWIGVSERGLFVGITNRWNREDGAPDLAGERSRGLLVRDALRADDAAAAVALVQEQVAEFEYAGFNLLVADREEASYLEWDGDLRVQVLDPGVHVIVNPGKNEADERAVRLRGELASVASGAGNATEAEGVADASSPSTWLDAATERLRDHDYEVCLHHDRFGTRSSSLVTIGADGATTYDFADGPPCETAYAPVEMPAVLREASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYE1</accession>
    <name>R4VYE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447169.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11660"/>
    <dbReference type="EnsemblBacteria" id="AGN02275">
        <property type="protein sequence ID" value="AGN02275"/>
        <property type="gene ID" value="L593_11660"/>
    </dbReference>
    <dbReference type="GeneID" id="16182295"/>
    <dbReference type="KEGG" id="sali:L593_11660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2403"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OrthoDB" id="40120at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="481" mass="49660" checksum="07C0575DF389F206" modified="2013-07-24" version="1">MSVPNPLRWLLLAVGRRLAALDLVDRERIERATDLSWPRIVTGLARMSKSVADVAMVGIALGPAAIAGVGFGGAFWGLAFALGGGVAGGTISLVSQRYGAEAYDELSTVVTSSAVAAVLITMPIAVLFAAIPETLIGLVGSGAGDQSVEYGATYLRILSIGVPLAGLNLIGSRALVGADDAWTPMLVRGGGAIVNIGLNATFIFGLGLGVTGAALGTVLGNVLVAGTFAAGLLRGSLPVIGEFPVTVSLRDAPIFDRGILRDLGRIASPLVLSNTAGNAARFPLLFLVGQFGETTVAAYVIGRQVRNLLNTPGWGFSLASSSLVGQELGAGDEQAAGAYGRDILRYAVTVYAIGAIGAVIFARPIAMAFVNEASTLPLATTFVRVASLSVIFWGVSGAATGPLRASGDTRWPFYANLLGRYGFAIPLAMAGVWTPLGLWAIYASILAETVVPAAVNYHRFATGKWKAVSREFRPDTVPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYG2</accession>
    <name>R4VYG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447194.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11785"/>
    <dbReference type="EnsemblBacteria" id="AGN02300">
        <property type="protein sequence ID" value="AGN02300"/>
        <property type="gene ID" value="L593_11785"/>
    </dbReference>
    <dbReference type="GeneID" id="16181905"/>
    <dbReference type="KEGG" id="sali:L593_11785"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="360" mass="38438" checksum="C61B509D35159808" modified="2013-07-24" version="1">MDQRADRASGPETDATTDPIVVDGLTKTYGDVTAVADVSFSVRDGEIFGFLGPNGSGKSTTIKAMLGLLHPDTGTVRLNDHDVATDGKAAKRDVGYLPEALGFYDNLNAVDTLEFFAQLRGVTDPDVHAALAEVGLEHAKHRPVDTYSKGMRQLLGIAQATIGSPSTYVLDEPASGLDPRWVRNVREKIFALRDAGATIFLSSHILSEIQRLCDRVAIIDDGRLLVVDTVAAVGNHLEITPQLELTVPGLDGEMPQVLYKLDGVETARADGDTLLVTSTPGTRATVVARLVQAGYTVADFRTLEPSLEEAFVQLIAEGDDDGWTGGPNRGGIGTGSADQGQPSPTTTQHDDYGRREADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYN7</accession>
    <name>R4VYN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447269.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12160"/>
    <dbReference type="EnsemblBacteria" id="AGN02375">
        <property type="protein sequence ID" value="AGN02375"/>
        <property type="gene ID" value="L593_12160"/>
    </dbReference>
    <dbReference type="GeneID" id="16182699"/>
    <dbReference type="KEGG" id="sali:L593_12160"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_6_2_2"/>
    <dbReference type="OrthoDB" id="21012at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="35543" checksum="EB2859BF74E628DF" modified="2013-07-24" version="1">MDFGYHNASFEYADDPESRSLVDSLVDRAQLVEDAGFTWFSLMDHFWQLQWSGHLDEDFVECYSGLSALATATDDIDLSALVTCIHYRNPAYLAKVVASLDQLSEGRAILGIGAGWYEDEYDAIGVPFEDPAKRIRELRDVIKLCQTAWDEDSPVNYEGQYHDLDDLILEPKPDDVPILVGGGGEQLTLRVTAEYADMWNIPGSDPETYEHKLGVLKEHCENAGRDYDEITKTATITTMIRDTTEEAHEAYEDHLEASKAGPADRDEFRGLVGTPEEVAEGVETYQDLGIDSFQIQVPKNERETTVRFIDEVAPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYP8</accession>
    <name>R4VYP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446255.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07070"/>
    <dbReference type="EnsemblBacteria" id="AGN01361">
        <property type="protein sequence ID" value="AGN01361"/>
        <property type="gene ID" value="L593_07070"/>
    </dbReference>
    <dbReference type="GeneID" id="16181999"/>
    <dbReference type="KEGG" id="sali:L593_07070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1445"/>
    <dbReference type="eggNOG" id="arCOG02274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099316_0_0_2"/>
    <dbReference type="OrthoDB" id="78391at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="244" mass="27475" checksum="35091CE2676F363E" modified="2013-07-24" version="1">MSLHEASFRVKHECPYREISERHPDLTIKEWYLDECQVVEVTAPEPPTEALREEIRSLGTVLHESVDESGLHVVTQSCLCSLEDSIVQRFEDHNALYQPPTIHRQGWEHYSVIAFDEADVRALLADLEADRDVEVLSKTAIAEQQLPHSMLAPVDQLFETLTDRQLAALRFALERGYYEQPRGTSLRELADATEVARSTFEEHLRKAENKLLTNAGQFLRLVTASSGGDPLGVQSADAVEQPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYV4</accession>
    <name>R4VYV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446320.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01426">
        <property type="protein sequence ID" value="AGN01426"/>
        <property type="gene ID" value="L593_07405"/>
    </dbReference>
    <dbReference type="GeneID" id="16182116"/>
    <dbReference type="KEGG" id="sali:L593_07405"/>
    <dbReference type="eggNOG" id="arCOG06252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2784276_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="68" mass="7110" checksum="FE33706B9DBB9448" modified="2013-07-24" version="1">MAESSVDEGPIQSVSTRIRLDGGSGECEACGGSIEGGERFKVAAVRTGGRIVYHDFCGGDCIDNWQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYX5</accession>
    <name>R4VYX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447359.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12630"/>
    <dbReference type="TCDB" id="1.A.16.4.3">
        <property type="family name" value="the formate-nitrite transporter (fnt) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02465">
        <property type="protein sequence ID" value="AGN02465"/>
        <property type="gene ID" value="L593_12630"/>
    </dbReference>
    <dbReference type="GeneID" id="16182482"/>
    <dbReference type="KEGG" id="sali:L593_12630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2592"/>
    <dbReference type="eggNOG" id="arCOG03454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061519_0_0_2"/>
    <dbReference type="OrthoDB" id="81794at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="33620" checksum="6450688E80E2F697" modified="2013-07-24" version="1">MDEDGPGDESVRDAIEQSRHGAPAAGSVVRDQFETHEVFQRIVAAADEEATTGTRELFFSGLAAGFAITVTFLLYASLTASTGRDPILSALLYPIGFVFIILGGYQLYTENTLPPVVLVLERLASIPRLLSIWGTVLAGNFAGGAIGAIVLARTGVLSPAGTDAAVYIASRGYETAFWSLFFKAAFAGFIVAGVVWLIYAVRDSVTRFLVVYVAFLTIPYADLFHVVVSFTEVVFLVASAEAGLLDGLGQFVLPVLLGNTVGGVVLVTVVNYFQTTEQRLHVARHDAVDRTLDARELVFGRRAGRSYIPSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYZ2</accession>
    <name>R4VYZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446360.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07605"/>
    <dbReference type="EnsemblBacteria" id="AGN01466">
        <property type="protein sequence ID" value="AGN01466"/>
        <property type="gene ID" value="L593_07605"/>
    </dbReference>
    <dbReference type="GeneID" id="16182757"/>
    <dbReference type="KEGG" id="sali:L593_07605"/>
    <dbReference type="eggNOG" id="arCOG02492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027480_4_2_2"/>
    <dbReference type="OrthoDB" id="26059at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="399" mass="41391" checksum="80140D62226D64C0" modified="2013-07-24" version="1">MNYTRRDLLATTGTLGIGTLAGCTDAVPLLGDDSDSGPSSLENDVAPDEWPGFQRTITNSGFVEDEARPTSEPAASWNRSLSGGLSDQPAVVDAPDSRLAIAVTEEGTVHALDAASGEDVWSRELDGASGQCPAVAQGLVVVGTDAGTLYALVLDSGDSEWSADLPGPVSGPTIAGDTVFVGTAADEETGTTPHACAVPLESGELAWSVEIAENAVDYPAVAGGNVYFGAEWTAGLQGHLHALDPADGTEQWHREGARMQPPTATEDFVLAPHLSPRVYGHTGRLRARNSFSGHVIGSPATDGELYYTGTTGRYVFPNELVGPGPDWFTAVGGRPTAAPALTESTVYVTRAEDDVVALDRSDGAIRWSWNAEGDVVTGPTVADGAVFVGTAEGTLIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZI3</accession>
    <name>R4VZI3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin synthesis protein/P47K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446555.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08580"/>
    <dbReference type="EnsemblBacteria" id="AGN01661">
        <property type="protein sequence ID" value="AGN01661"/>
        <property type="gene ID" value="L593_08580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181809"/>
    <dbReference type="KEGG" id="sali:L593_08580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1757"/>
    <dbReference type="eggNOG" id="arCOG01233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_0_2"/>
    <dbReference type="OrthoDB" id="27680at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="328"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="489" mass="52236" checksum="9B2C7B44A8C94331" modified="2013-07-24" version="1">MAGNDGIPVTVLAGPLGAGKTTVLNHLLTDAGDRRIAVLVNDMGEVNVDADLLAAGSDLAADGGVAELSNGCICCELQDDLESEVARLAEEREFDVLVVEASGISEPGPVGRLFVTDSRAAAVYDLDTLVTVVDAPRFWETFGGDEEAAGHPEGGASHAEESARDGEDGGNDGSLAGRVERETAPGSTDRPLSDLVIEQVETANVLLLNKCDLLDDEHLGQIEALLGALNPDAPIHRTVHGDVDLDLILETGLYAEQRDASAAGGLSDARTGLEHSSPEEEHGHEQEGLSDDSGHGEHDGHDHDHDHHDSHGDQDHHDHDHPEAVYGVDSVAFRRRRPFHPQRLLAVLGDLPPAVVRSKGLFWAAGRDDLALLYSQAGPTGSVEGVGPWIASLPDVEADLYRSNTPDLPWEEPHGDRRSELVFIGRDVPEEELFGALEDALVTDEEWDPEDGWLGENDPADAVGLPASDEDDERLEFSPRESEGFDPTA</sequence>
</entry>
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    <accession>R4VZI5</accession>
    <name>R4VZI5_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02680">
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        <property type="gene ID" value="L593_13705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13705"/>
    <dbReference type="eggNOG" id="arCOG09147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="8296" checksum="F633D26596203B08" modified="2013-07-24" version="1">MSNSADRWRFCCPAGHRSWEPTNNHFWCQQCASRPVGPDPEFYELRDRKTNELIERDQIEVVDDGGLEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZS6</accession>
    <name>R4VZS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="gene ID" value="L593_08855"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="24104" checksum="A0553A97651FE281" modified="2013-07-24" version="1">MVYTGVANLLVGTLLAMLLVREFAASGFVSRSRLGFRSIGRTVVAVLIGGGLGFALFALQQPPTTDPVVVANVFAQVLPVSIAEIVICWVVVGGSLEALLRHRGLNRYLATGSALVVSSVLFGVYHFAHSPPFNTVEMVVLLTVVGVGTGLIYFVGRSFYGALAFHNFMALIGVVSSLEEDGQIGSYQQPLPPLLATALVAVLVMVGIERLFVRDTYEEEPGDHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZX2</accession>
    <name>R4VZX2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01771">
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        <property type="gene ID" value="L593_09130"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1872"/>
    <dbReference type="eggNOG" id="arCOG02808">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212638_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="103"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="24652" checksum="E5380F1A4AF15EA7" modified="2013-07-24" version="1">MLPGGAPSGRAASSLGDAEFLARTDHRVAVLAALADGPKSRRELEALADVSRTTVGRTLTAMAHREWVERDGDRFEATPLGEFVADSIVSLLDDLETTRRLRDVWELLPVDEEGFDVVLSNGVINLSPEKGTVFAEANRVLRSGGRLAISDIISETTMPDSIKTDADLWAACIGGAMQINTYREAIEAVGLDVVEVRENPLYEFTSDRARGACEKYGVKSVSLGALHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZY7</accession>
    <name>R4VZY7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447714.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14405"/>
    <dbReference type="EnsemblBacteria" id="AGN02820">
        <property type="protein sequence ID" value="AGN02820"/>
        <property type="gene ID" value="L593_14405"/>
    </dbReference>
    <dbReference type="GeneID" id="16181247"/>
    <dbReference type="KEGG" id="sali:L593_14405"/>
    <dbReference type="eggNOG" id="arCOG09098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933347_0_0_2"/>
    <dbReference type="OrthoDB" id="129986at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="13492" checksum="AD2B902A32FC93C9" modified="2013-07-24" version="1">MARNQVDTIDVGALTIVPIAAAMVLGVFALNISVFGIGSLSQPIVGSGTSAITIPLVLYLGGLGWIVGTNELDGSDYEDYELALIGFAFLSVPMYVFVPVFADLVGISDVIRLLLALGISAAAVLISYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W017</accession>
    <name>R4W017_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_09380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446715.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01821">
        <property type="protein sequence ID" value="AGN01821"/>
        <property type="gene ID" value="L593_09380"/>
    </dbReference>
    <dbReference type="GeneID" id="16182690"/>
    <dbReference type="KEGG" id="sali:L593_09380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1929"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OrthoDB" id="58645at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="61"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="31608" checksum="7D6132AF62427B94" modified="2013-07-24" version="1">MPEEPDVNISGGASGGGRETRFEADDPSTRAEAVVDRLGDLFWQKTYGDRDPFDCLVRTILSQNTSDVASQPAYDALVERFDPARGDGIDPDLAFAAGDDGPADLAEALATADRVAIAETIAPAGLHNQKSKVLQTVAERILAEYGSTAAFDDFVATADYADVRDALLDFGGVGPKTADCVLLFAAGRQGVFPVDTHVHRIYRRLGIAPPDADHEGVRAVLEREVPGEKCGFGHTASIQFGREYCSARKPACLDGPEACPLYDRCDRVGVDPESRAVVDPESRVVVDPADAAAATED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W063</accession>
    <name>R4W063_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09630"/>
    <dbReference type="EnsemblBacteria" id="AGN01871">
        <property type="protein sequence ID" value="AGN01871"/>
        <property type="gene ID" value="L593_09630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180449"/>
    <dbReference type="KEGG" id="sali:L593_09630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1983"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362749_0_0_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="653" mass="71649" checksum="7BF96DB7DB7DBC46" modified="2013-07-24" version="1">MTEESPAPDRAAPNPEELSAIERALVELYEIKRGDDGFEAKTEQLLEVASAYLGVEAAHLTRIDPADDYWEAVVSTDEDDGQFPAGLVLPYSTTYCRHVVEKDGSVALHDATEQGMADDPAVQTHGLSCYHGTPIHLDDALYGSVCFVGSDPRDEPFSESDTLFAEFVSRIVEAELQHAHQQAETTRRANSITVLSRVLRHNLRNDMTFVRGRVASLIDEIDADSSDLEQLVEAVDEIIELSDKARKLEMVVSTQFEQEEVALGTTLERAITNATSTDGPASVELTGEVTTSITAMPSLELALTELVENAVKHSGPEPTVTVTVSAENGTVTIAVADDGPGLPESERRVIADGSETPLVHGSGLGLWMVYWIVDNHDGAIEIDVEDGTTVTVTLPRRSDPSSTGEMRRLTRGYDRFQAVFEKSFDAMVVVDDDRRIVDANPHAAELLGVRKQELLGRTIGEFAVAEIDRDEMWRRIQAGGSGEGTFSLVDADGNRRTIEYTATADVVPGQHLLVGRDVTERIERERRYEALSKGFPYLCFIIDEGCVYRDVLASPASEDQLYADPDEFLGESCDAVLPDDVAETTMEAVDQTLQTGTARELSYELEVPAGERRFEARTYPLSKRIEGRRAVSLVVRDVTDGERQPRSSVGPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W081</accession>
    <name>R4W081_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09730"/>
    <dbReference type="EnsemblBacteria" id="AGN01891">
        <property type="protein sequence ID" value="AGN01891"/>
        <property type="gene ID" value="L593_09730"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2003"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="30137" checksum="A3A37F976B18E5B0" modified="2013-07-24" version="1">MHDGIDGAAATNRGVDVTYATAGEGEAVAFVPTLGYGAWQWGWQFPAVAGPFRAIAMELRGTGGSDAPPGPYDVATLAADLEAVLADAGVRRVHIVGFGLGGHVALEYAAQYDRARSLALIGTTPGLPEGDLPGRVRAEDGTDRDLVDALFAPAGNPDALRASLSPALSAAFRAEHPDVIEGIAEWRADEDADRAGWNAQAPAFTDWERSWPPYEMTEPTLVVQGGADRVVSPDNAAVLEELLPDAERVDYPDAGHLVTVERSRPLNDRLIGWLERHASIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0P5</accession>
    <name>R4W0P5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA_27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10880"/>
    <dbReference type="EnsemblBacteria" id="AGN02121">
        <property type="protein sequence ID" value="AGN02121"/>
        <property type="gene ID" value="L593_10880"/>
    </dbReference>
    <dbReference type="GeneID" id="16180052"/>
    <dbReference type="KEGG" id="sali:L593_10880"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019085_0_0_2"/>
    <dbReference type="OrthoDB" id="90713at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_27" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="791" mass="86332" checksum="1D1504B7897D1E52" modified="2013-07-24" version="1">MRLQSVRVDRYGPLSGVEHEFDGGLEVCYGPNESGKTLLLDALLRLCSPDAVDVVPEVGRVGEPPVGHAVIETTAAPERAEDAATDGGPSPAGTTEHVLGDGTTLTDVTAVTPRQLRNVFVVRDADLRLGDEHEFYDATARRLADLHTAELDALRERIVDAGRLTPTTLNLARAEDHGNAKDVRDDAAALADRIREYVGECRDAGIESAERERVEVATELERQRRALDRQRAAETLATHDRLADQLSTVRDATAALQDRECTESGLDRLEAIEAELERIDDDIADVEDRREQLREERSTRESERDDLAAERDQLEARIADLEDVEQALEGYRDGGSASPAGTPERHGAILAVVGVVGAAVAAVAGVTVAALGLTIVATIGAIWAVVSYRRSRATAGDRRSVLAAARDAGLAVETIADVAPAIRELQDERDRLGNRIDATERQIEVIERRLGDVEEDREDAIERRRTLRRERRERLRDAGLPDVAAYRDAVEEAESLERERRDAVASLTERLGAPAADTNDDSGSIEARIDYWDRELDGLRTDVQRDDVAAEEFDPEERDALAAAVDRLESRVDELDTRLDDHEAAIDGFDDELGRLPTGRFREEPIALAARSVDGLAATARDLESLVEDLERNADVSRAALAALEGVRADEEAKLADLFGPESTASATFRSITDGRYEAVTYDPDAETLVVEQADGTTLPAGALSRGTTDQLYLAARIGLADRLLHGEPGFLLLDDPLLPADPERLAAGFDALRTLAADGWQIVYFTAKPEVGEALVERHGVPCRRFDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W135</accession>
    <name>R4W135_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447160.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11615"/>
    <dbReference type="EnsemblBacteria" id="AGN02266">
        <property type="protein sequence ID" value="AGN02266"/>
        <property type="gene ID" value="L593_11615"/>
    </dbReference>
    <dbReference type="GeneID" id="16180283"/>
    <dbReference type="KEGG" id="sali:L593_11615"/>
    <dbReference type="eggNOG" id="arCOG01286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_0_0_2"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15060" checksum="9803B1DBA670708C" modified="2013-07-24" version="1">MSDDASPRILTDGGEDAAGDEGYDEWLAAVSDGEGYYLACENGHGSLPPRRRCPHCGSGELDEKPLPASGTVETFTETQVPIPSFEEDAPYVVAIASFGDVRITGQYREIDPGEVAVGQSVRVDVSERETTGEPLVVFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W168</accession>
    <name>R4W168_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447205.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11840"/>
    <dbReference type="EnsemblBacteria" id="AGN02311">
        <property type="protein sequence ID" value="AGN02311"/>
        <property type="gene ID" value="L593_11840"/>
    </dbReference>
    <dbReference type="GeneID" id="16182322"/>
    <dbReference type="KEGG" id="sali:L593_11840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2437"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035683_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="269"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="596" mass="65282" checksum="C5329E475A5EB72C" modified="2013-07-24" version="1">MPSTGLSRRSLLTAASGGAAAATAGCFSRLRSQITYDAADPISLSVKTVPADRDPSAVLLGRELADHLETVGIDVSHDLIDEVQLLRDAFFNHDYDLFVTEIPGHRDPDELRALLHSQFAPELGMQNPFGYASPRTDDLLEAQRRPATGTDDPASDNPASDNLATDDRAMLVERLQRQLLEQQPFLTVVSRPHTTAVASDLTFSGGVSFASSLAYLTVDRPEGDLDTLTVGLQRPNVTRNRNVLAVEYRLHDRLTDLLYDPIVQRVGDQYVPWLAAEYSVHGQSNTITVDLRPNLSWHDGTPLTASDVAFTYRFCKDTALGGTDSPVPAPRFRQQTSLVRSVSDVDQTTVEIELHPTRVGLAPTALTVPVLPEHVWNSRSSLQHEYFTRAITASVSSPVGSGPLRFDSAEEGQSLTLQRFDDHFLRTTSDLPNALQPFAGGPAYETLSAESAPNIGVVLDDIAEGRVQVLDGTVPVDDVPDARDRSDVRVLESPTPSYYLIGINTRRHPLSNYAFRSALGRLIDRDHVVEAVFDGIAMATETPLHDTAYVSEELRWDGESVTGGFPGEDGQLDRDAARQLFRDAGFRYQEGSLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1M3</accession>
    <name>R4W1M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447420.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12935"/>
    <dbReference type="EnsemblBacteria" id="AGN02526">
        <property type="protein sequence ID" value="AGN02526"/>
        <property type="gene ID" value="L593_12935"/>
    </dbReference>
    <dbReference type="GeneID" id="16180254"/>
    <dbReference type="KEGG" id="sali:L593_12935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2652"/>
    <dbReference type="eggNOG" id="arCOG00237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_1_2"/>
    <dbReference type="OrthoDB" id="65032at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="315"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="615" mass="64617" checksum="CEE716C47AF55FBF" modified="2013-07-24" version="1">MPVAGVSTGAIVVFALIGVALVLFVSETFPSDVTALGVVVVLALLEPVIGLTPREAISGFSNPATITIVAMYMLSAGIQETGIVEWLGVKLAAFTRGEEDRALAATVCTTGPMAGFVNNTPIVAVFIPMVQDLARDADISPSKLLMPLSYAAILGGTLTLIGTSTNILASDAARELIRGREGIGIFEITPLGVVVLAVGIAYLVTIAPRLTPARVPVDADPLERFDMEDHLGRVVVREGSPLVGTSVDEVAESVAVGGEIAVLQLRRNGEVYAVPDADEALRPGDRLIVNGTLQAINRFQEANDLRHLHRESVTAATFDEAPTGYTLATAVIPEDSEFAGETARGIGLERFHQTRVLAVRRDGELYRTGLREFALEPGDHILLRTTPQTIEYFDDSPAIWIVDERVLEAHANGDDGPTLSSHTPVALSILVVVVLGAAVTPAPIVVAALGGAFGMMVTDCISPADAYDAVSWNVVFLLAGVIPLGLAMERTGGATVLADLLVASAGVLPLLAVLYCFYLVTSLLSNAITPVATIVLMLPVAVDTAAQLGANQFAFLLAVTFAAATPFLTPIGYQTNLMVYGPGGFEFTDFVRVGAPLQLLLSVVTTAGIWAFWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W272</accession>
    <name>R4W272_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14010"/>
    <dbReference type="EnsemblBacteria" id="AGN02741">
        <property type="protein sequence ID" value="AGN02741"/>
        <property type="gene ID" value="L593_14010"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2866"/>
    <dbReference type="eggNOG" id="arCOG09104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17408" checksum="38BAA5A896C63A02" modified="2013-07-24" version="1">MANGDASRADADRSASTTALPRQNTSLLVRALWFVFVGWWLTGIWLAVAWFLLITIVGAPLGIVLINRIPFVLSLKRRDVRTQIVTEGDETTTETTRPEQSSILLRAVYFLLVGWWLSLLWTTVAYAFTVSIIGLPIAIWMFGKLPYVVSLYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2L6</accession>
    <name>R4W2L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_15060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447840.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15060"/>
    <dbReference type="EnsemblBacteria" id="AGN02946">
        <property type="protein sequence ID" value="AGN02946"/>
        <property type="gene ID" value="L593_15060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180813"/>
    <dbReference type="KEGG" id="sali:L593_15060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3076"/>
    <dbReference type="eggNOG" id="arCOG03860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060475_0_0_2"/>
    <dbReference type="OrthoDB" id="56787at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="33211" checksum="A415069119D47038" modified="2013-07-24" version="1">MDQSSFEEAVDPDEAFAVLSDDNRIAILRALWELDEYSASFSDLHDSVDVADSGQFNYHLGKLTDQFVRKTEDGYKLTAAGIRVVGAILGGAYTMAGSMDPVELDEPCPSCDGRWQFRYEDEFARMECESCSMAIQYPVPPGTFVGVAHAEMPARTERYLRTLLEQLRNDVCPYCEGETESRIVVVEEPSDGIEELQSIPLVRYDCTRCAGELTTDVGTPLLADPTIVSFFHDRGVDVRERSLWQFAAFDDEDTSIEASDPYRVTVTFEADGEELVVTVDESMNVLDVEGPGRSTEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W357</accession>
    <name>R4W357_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01880"/>
    <dbReference type="EnsemblBacteria" id="AGN00327">
        <property type="protein sequence ID" value="AGN00327"/>
        <property type="gene ID" value="L593_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01880"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="20349" checksum="0957BB148D794965" modified="2013-07-24" version="1">MQRAHTVHMPRGFYVGRFQPLHEGHEALLREIARERDELVVGIGSADKSHSVDNPFTAGERHVMLTRTLETIDVDAYVVPLVDVDRNALWTSHVRSLCPPFDDVYSNNPLVTRLFEESGTDVHDLPMFNRQEYEGTGIRERMLSGDPWEDLVPDQVVDVIEEADGVGRLRDVAADDVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Q6</accession>
    <name>R4W4Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-galactosidase/beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446166.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06625"/>
    <dbReference type="EnsemblBacteria" id="AGN01272">
        <property type="protein sequence ID" value="AGN01272"/>
        <property type="gene ID" value="L593_06625"/>
    </dbReference>
    <dbReference type="GeneID" id="58789347"/>
    <dbReference type="KEGG" id="sali:L593_06625"/>
    <dbReference type="eggNOG" id="arCOG07337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435912_0_0_2"/>
    <dbReference type="OrthoDB" id="27998at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="66608" checksum="B4F79995B9FF3DB1" modified="2013-07-24" version="1">MEFEWQGAVVDEVGGEGPPEPASWERVAVPGRPSSLAGADAVAYRTRFADPRSADVERGLLTIEGVYATATVYLNGQQLVRGDWAAPIRAPFSPMEENELVVVCRSAEDRFGGIEDTGRVPASARVPSIRGGVEVEAVPPVYVHDLTVRGDLDGEEPTIEVSALIDAAKPIDDRLTLSLRPEGFRASGSMERLAVSADAGERVRAEGSVQVRNEQRWWPYDLGEQPRYTVRAKLDAHERSATTGLVDVEREGGEFLLNGARHRPRGVTVPPNADPETVVENALDANATLVRARGHVPTKRLAEACDEAGLLYWQDLPIVGPDGSGPDAAGPIDVERGRNLARALAASRGNHPSLVAWGVHDDPADPYGGLGGGTLDKLKFRWRAWRSDYDSAGAEALAGSLPADSIVFPVTGPPGTDADAVHAYPGWEYLEATDAEWLLEQFPEVGDVVGSFGAGSLSRPGDGHAAGLDRGHFSAGAAGDPDATQAEQARTVRTVLDALRRNGVGTLVLDSLQDADVSGGMGILDAEGERKAGFHGVARGFMPLQAVLDGPPRGGSSVGITLCNDTATEYTGELAWTAGGRNGATDVTVGPWERADGGAVDVPDAADRLTLEFRIDEGTVTNSYDLTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W584</accession>
    <name>R4W584_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446471.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08160"/>
    <dbReference type="EnsemblBacteria" id="AGN01577">
        <property type="protein sequence ID" value="AGN01577"/>
        <property type="gene ID" value="L593_08160"/>
    </dbReference>
    <dbReference type="GeneID" id="16182318"/>
    <dbReference type="KEGG" id="sali:L593_08160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1674"/>
    <dbReference type="eggNOG" id="arCOG02941">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092679_0_0_2"/>
    <dbReference type="OrthoDB" id="80478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22319" checksum="EBC95EFD31241B20" modified="2013-07-24" version="1">MAAHGRPALRELFDDSPTPHIAHPPRTHHRDYYLATDGSFREMGGGLGVVAETRTGDRVLRLSLPDAAPDNNVAEYRALHLGLDVLAARVPRGSSVGVLIDHDDLAANVNATVLADGSRTRDPFPDVTLPPATAHHWRGIRARIAGFGGFRAARIDSDVNPAHPLANDPDSYAHVNEESDRSVRSGPDPLADGEQIPPPSRADRHAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W598</accession>
    <name>R4W598_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446496.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08285"/>
    <dbReference type="EnsemblBacteria" id="AGN01602">
        <property type="protein sequence ID" value="AGN01602"/>
        <property type="gene ID" value="L593_08285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182357"/>
    <dbReference type="KEGG" id="sali:L593_08285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1698"/>
    <dbReference type="eggNOG" id="arCOG04631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049702_1_0_2"/>
    <dbReference type="OrthoDB" id="25059at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="433" mass="48828" checksum="7F964E370CF24C2C" modified="2013-07-24" version="1">MGLIDDLERFHSVGEDRREDLKEFVAYGDLSASDADSVRVPIKIVDLPEFAYDKRDQGGVGQGDAEVGQPVDAEPQPGDEEGDPGEEGGEHEYYEMDPEEFAEELDEELGLDLDPKGKQVVEEIEGDYTDVARAGPDSTLDFERMFTEGLKRKLATEFDEDFLREVCKVEGITVGDVFEWARDEHVPVSHAAVAKLHGEVADERGAWESIADVEANVERTPVRQRIREQGLDHVPYRREDERYRYPEVIEERERNVVVVNIRDVSGSMRQNKRELVERVFTPLDWYLQGKYDTAEFVYIAHDAEAWEVEREDFFGIRSGGGTKISSAYELAEELLDSYPYSEWNRYVFAAGDSENSSNDTEQSVIPLMEAIDANLHAYVETQPSGNAINATHAEEVETYFGEDSGDVAVAYVSGQEDVTDAIYEVLSTEDDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5C8</accession>
    <name>R4W5C8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_08535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08535"/>
    <dbReference type="EnsemblBacteria" id="AGN01652">
        <property type="protein sequence ID" value="AGN01652"/>
        <property type="gene ID" value="L593_08535"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1748"/>
    <dbReference type="eggNOG" id="arCOG00462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="74"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="37022" checksum="B12E0694C034FF99" modified="2013-07-24" version="1">MSTEEDPDAASDRDATDSDADATGADRDLPDGVSLPDDLDAVQDALLSWYREDHRSFPWRETTDPYAILVSEVMSQQTQLSRVETAWHEFLERWPDAAALADADRADVVAFWTDHSLGYNNRAKYLHEAARQVTDGEAGGDDLAAGEFPTDPDGLQDLHGVGPYTANAVASFAFNEGDAVVDTNVKRVVYRAFDVPDDDAAFEAAAAELMPAGESRDWNNGIMELGGVACEKTPSCDEAGCPWRQWCHAYRTGDFTAPDVPTQPPYEGSRRQKRARVLSALSEHGSQALDELGPRVRVDYAPEGDGDGSREWLRGLVEDLEADELVTLGENGTVELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5M5</accession>
    <name>R4W5M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09410"/>
    <dbReference type="EnsemblBacteria" id="AGN01827">
        <property type="protein sequence ID" value="AGN01827"/>
        <property type="gene ID" value="L593_09410"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09410"/>
    <dbReference type="eggNOG" id="arCOG01414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602200_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="454" mass="49342" checksum="08734733BF38BA40" modified="2013-07-24" version="1">MTTIATPGDASCGIGTYARDLRAALEDLEPDRRRERESGATVSGSDGPTTSETPGASGASGTADGPAVTDEPGRTDGLTTTDAIDLEQDYPTAGHFISIALRAAARDSDVVHVQHEYGLFRRPGSSYPGLYGLLFFPVLWLATRIRRKALVVTLHSVLSPAPEEARFAKRCYLLVMHELIARVTDHVIFLSSDCEEQFHEDVAQDPTEYSVLPHGVNVRDSSPADRSTARERFGFDPDDEIVVIPGFVRPPKGHDIFVDVAKQLPDVEFLIAGGARPKGFDQEFVDEVEADAPSNVTITGVLDDEEFPMALATADLALLPYRVVTQSGTFNWCAAEELPVLASDRSYFRQIEAEWDALETIGLDDTAAIADRVATLLEDDEQRDALASGIRTYKEANSFETVAAEHLQIYRRILAGVPARRVDDAEGGTTRIPVEDESMLAACSAQREATVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S5</accession>
    <name>R4W5S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446806.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09835"/>
    <dbReference type="EnsemblBacteria" id="AGN01912">
        <property type="protein sequence ID" value="AGN01912"/>
        <property type="gene ID" value="L593_09835"/>
    </dbReference>
    <dbReference type="GeneID" id="16180912"/>
    <dbReference type="KEGG" id="sali:L593_09835"/>
    <dbReference type="eggNOG" id="arCOG04567">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080903_0_0_2"/>
    <dbReference type="OrthoDB" id="83902at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="230" mass="25326" checksum="97DE48D70ECFA57E" modified="2013-07-24" version="1">MTTFADGPAETPEFTRYSDVLEWLAHADERGRRASHAIDGDDGVWIVDPLDAPGLDEELDRFGAVAGVAVLANYHARDAGQIADRYDVPVHVPSHFERVTERIEAAPVERFDSALGDSAFAFRHAEPAPGWRETILEYVDLLYAADLLGTGPTYTVDEERIGVYLLRRPFPPRDRFADAEPERIFVGHGRAVTDDANTALADALAGARRRFPRAAIRHGPGQLRALLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W638</accession>
    <name>R4W638_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="6" type="ORF">L593_10735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446986.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10735"/>
    <dbReference type="EnsemblBacteria" id="AGN02092">
        <property type="protein sequence ID" value="AGN02092"/>
        <property type="gene ID" value="L593_10735"/>
    </dbReference>
    <dbReference type="GeneID" id="16182049"/>
    <dbReference type="KEGG" id="sali:L593_10735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2213"/>
    <dbReference type="eggNOG" id="arCOG00078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="OrthoDB" id="58340at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22877" checksum="6F40453AFE3950D8" modified="2013-07-24" version="1">MSLPDGVERRQFDNEERLATRGPSVYGEPTDGAWRAWDARRSKLGATLEKGMETGLDGGDSVLYLGAASGTTVSHVADFAGPTYAVEFAPRPARDLVGVAEDRDRLFPLLKDARKPETYAHVVESDLDAIVQDVATRGQARVALENRQFLAEDGRLIAAIKARSEDVTAEPADVFEDVLGDLEDGYEVLDTERLEPFHDDHLAVVARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C1</accession>
    <name>R4W6C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11335"/>
    <dbReference type="EnsemblBacteria" id="AGN02212">
        <property type="protein sequence ID" value="AGN02212"/>
        <property type="gene ID" value="L593_11335"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2338"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="20228" checksum="895673A592EA4D04" modified="2013-07-24" version="1">MEPEAIRVTDAAMSEDAEIAPTATLSPAGVEGEPPVLGAGATVRGGTVIYPDVVIGEGFSTGHDAVIREATRIGDDVLVGTMAVIDGHARIGDGTSLQTNAYVPTQTIVGDRVFLGPGATLTNDATPVRDEATGLEGPTLNDDVTIGANATILPGVEIGEGAFVAAGAIVTEDVPPQTLAVGTPAEHRALPTDLEGRNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J4</accession>
    <name>R4W6J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445322.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02385"/>
    <dbReference type="EnsemblBacteria" id="AGN00428">
        <property type="protein sequence ID" value="AGN00428"/>
        <property type="gene ID" value="L593_02385"/>
    </dbReference>
    <dbReference type="GeneID" id="16181416"/>
    <dbReference type="KEGG" id="sali:L593_02385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.484"/>
    <dbReference type="eggNOG" id="arCOG00239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_2"/>
    <dbReference type="OrthoDB" id="69837at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="253" mass="26643" checksum="EBCB9DFF2EF67485" modified="2013-07-24" version="1">MQIEDGAVRRLTFDRPDVRNAMTPEVATDLADALEDVDPSEHDAVVLTGEGEAFCAGGDIQAMAEREESAGEAFEVIQETFGRAAEAILDAPVPVIAKVNGDAVGAGTTLAALADFAYAAESARFGASFVNVGLVPDTGATVVLPRIVGLRTAKELAFTGKLLPAEEAADLDLVSQAVPDEDLDDEVAGLVSTLQDQPTETIALTKRAIHDNLGRSWEDGLDREAHLQVLAYDSDAHAEGVAAFLEGRNPNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L2</accession>
    <name>R4W6L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02535"/>
    <dbReference type="EnsemblBacteria" id="AGN00458">
        <property type="protein sequence ID" value="AGN00458"/>
        <property type="gene ID" value="L593_02535"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02535"/>
    <dbReference type="eggNOG" id="arCOG10675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661603_0_0_2"/>
    <dbReference type="OrthoDB" id="99645at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="415" mass="41857" checksum="1F1775251DDEBC72" modified="2013-07-24" version="1">MASVSSAATISRGARGLVLAGAGFLVASTFAAAITEPRSTIVAFGLYGFVLHTIFGKAYGLLPAYFDRDLAVPRAPQLQLPLAVLGTVLLAATPGSETDRLLPIAADVAADAGAVLWAAGSIVFLVTIALTIRDNPTGAETGTSASKADRARLDRIANAAMPIALAYLAIATYQLLAGAFDLPALVESPLAVSHLLTVGTATLLVFAIGARLLPRLIRAEVPDALAAAVLASGALGPALLVGWFDGGPFGLAVEGLLHGAIALLAVAVLGHAVLIVLLVSRAPAPRLGAYGVLAGAVGGVLTVAAGALVGLGERIELFAIHPRLGLLGFLGLTILGVVYHFYPPAVAGDRGDVVAAASLWSLGGGVFLELTAVLLGEGQPSGPTATAIDLGRWLAVVGALAYAGLLVVIVVNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U2</accession>
    <name>R4W6U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylmalonyl-CoA mutase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylamine corrinoid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447416.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12915"/>
    <dbReference type="EnsemblBacteria" id="AGN02522">
        <property type="protein sequence ID" value="AGN02522"/>
        <property type="gene ID" value="L593_12915"/>
    </dbReference>
    <dbReference type="GeneID" id="16180076"/>
    <dbReference type="KEGG" id="sali:L593_12915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2648"/>
    <dbReference type="eggNOG" id="arCOG01710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_2"/>
    <dbReference type="OrthoDB" id="89832at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15070" checksum="E44E7848625751BA" modified="2013-07-24" version="1">MSVEGEQRTIRCLVAKVGLDGHDRGAHVIARAFRDAGFEVIYSGLHNAPDEIVQAAVQEDVDVLGISILSGAHNTLVPKIIEGLEEYGAFEDTLLIVGGVIPDDDKQELKAMGVAEVFGPGTELETTIEFVRENVQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U5</accession>
    <name>R4W6U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12940"/>
    <dbReference type="EnsemblBacteria" id="AGN02527">
        <property type="protein sequence ID" value="AGN02527"/>
        <property type="gene ID" value="L593_12940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2653"/>
    <dbReference type="eggNOG" id="arCOG03887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="25107" checksum="927753854D63F6D3" modified="2013-07-24" version="1">MTDGSATGSDGDDGHGSPVAARPGPSRDPDVDALLDQLEELEQTVDSDDEREQVQETISLAERIPGTGFLSGQIQKYTTRDVAEAFVGAILISMPMIVEDGVFVIAEHLAHSRWQGVPVFLVANLAFVLAMSVGLLYVADIREVQIRNPILGFVPRRLVGVLAASFLAAVGVMYLWGRNEAGNPTDLELFARVTVIWTAGAFGAALGDILPGESAGYDITIENLDDIVKPEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z1</accession>
    <name>R4W6Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445542.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03485"/>
    <dbReference type="EnsemblBacteria" id="AGN00648">
        <property type="protein sequence ID" value="AGN00648"/>
        <property type="gene ID" value="L593_03485"/>
    </dbReference>
    <dbReference type="GeneID" id="16182442"/>
    <dbReference type="KEGG" id="sali:L593_03485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.707"/>
    <dbReference type="eggNOG" id="arCOG02842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_7_3_2"/>
    <dbReference type="OrthoDB" id="109503at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="110" mass="11789" checksum="38FDC55F9B7FDE2A" modified="2013-07-24" version="1">MTDYTVEFVGTGETITVADTETILSRCIEEGIAQEYSCRVGMCLACSAEILEGEVTQPAARALTEDEAERFALTCMARPQSDLKLDRGVYPPSIEDDAETTGDATAAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W706</accession>
    <name>R4W706_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase (Metallo-beta-lactamase superfamily) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447516.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13415"/>
    <dbReference type="EnsemblBacteria" id="AGN02622">
        <property type="protein sequence ID" value="AGN02622"/>
        <property type="gene ID" value="L593_13415"/>
    </dbReference>
    <dbReference type="GeneID" id="16180602"/>
    <dbReference type="KEGG" id="sali:L593_13415"/>
    <dbReference type="eggNOG" id="arCOG03009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_0_1_2"/>
    <dbReference type="OrthoDB" id="41674at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="68"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="39661" checksum="B14A7985A5CC2231" modified="2013-07-24" version="1">MRRLAVVGALLVLVLSAGCLGAIGVDVETETSSPDAGDSSGFDGEIGANASLEPVDAELSVHYIDVGQADATFVRGPENETMLIDSGHWSDGGEVVIEYLEARGVERIDYVVSTHAHADHIGGSAEVIDHYETERDGIGSVWDSGVPHTSQTYEDYLDAIERHDVDLYQTQANDTIPMEGATVEVLNPPIDHGDEDLDANAVVVRIGYGDAGFLFTGDMTTETEDDLVARWGSDLQSSILQAGHHGSSTSSAPEFLDTVSPRLAIVSSAYDSQYGHPHEEVLARFADRGIDTYWTGTHGTIVAGTDGDAVTISTVADARTDPADLRSSPAADASAIAPIEVRGTYDVGPDASALIVPAPLSPTSSVGSQPATAIAGGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W748</accession>
    <name>R4W748_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00728">
        <property type="protein sequence ID" value="AGN00728"/>
        <property type="gene ID" value="L593_03885"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03885"/>
    <dbReference type="eggNOG" id="arCOG13433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665572_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="16084" checksum="451445FC2089E042" modified="2013-07-24" version="1">MLVYAMGLAAVVLKHADAFGSLADRISAAGTDATALSAALEREAVPIVYDATIGALVSSSSPETTVLAGGVLVALGTVLLPTVVFLLVYLTRLSPGWKPTYLYPVAVLGPAAGLAAGATIDVPLTAELALFGLLPFGALVVMMLSAFVRPKLKAVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W774</accession>
    <name>R4W774_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FO synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_13865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447606.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13865"/>
    <dbReference type="EnsemblBacteria" id="AGN02712">
        <property type="protein sequence ID" value="AGN02712"/>
        <property type="gene ID" value="L593_13865"/>
    </dbReference>
    <dbReference type="GeneID" id="16180895"/>
    <dbReference type="KEGG" id="sali:L593_13865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2837"/>
    <dbReference type="eggNOG" id="arCOG00656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_1_2"/>
    <dbReference type="OrthoDB" id="26917at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="85"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="482" mass="53357" checksum="55AEAF83F1E29711" modified="2013-07-24" version="1">MGDGFICGVDVPEEGVSVSFDHFPCTDQSFENALERARAGDRLSVEDGVELITTGTDEPGIDPERKERVLEIANRRRAEAVGDEVTFVANLNNNVTTACNTGCLFCNFKDRSQKFRSEYQSDHGGFTKTPEESRRIVDDALDMGIYEVTSVSGLHPAFALDEEHREILEAKDDPTMVNYRPPAEYDTSPGTYVEQMAAMSVDDVHLHSMTPEEAYHAQRGADWDYEEVYGRLKDAGLDSVPGTAAEILVDEVRDVICPGKIDTEEWMEAMHAAASVGLDTTATIMYGHVENAMHRVMHLKRIRDLQECTGAITEFVPLSFVHEETPLFERGYVDGGASTDQDELMIAVSRLFLDNIDHIQSSWVKYGDAQGLKMLTCGADDFMGTILSEEITKRAGGDYGEFRSFQEYADMITAIGRTPVERSTDYRERRQIDPEADVIGPALGPRADGTPMVDHTPTPPERSSDESGDQEPVAPADAKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W793</accession>
    <name>R4W793_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447641.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14040"/>
    <dbReference type="EnsemblBacteria" id="AGN02747">
        <property type="protein sequence ID" value="AGN02747"/>
        <property type="gene ID" value="L593_14040"/>
    </dbReference>
    <dbReference type="GeneID" id="16181025"/>
    <dbReference type="KEGG" id="sali:L593_14040"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="262" mass="28384" checksum="47D7DFAAF24D28B0" modified="2013-07-24" version="1">MGTADHDRAVELLKELGMKTYQAECFAALNTIPSGTAREISEVADVPRTRVYDATEALAEQGFIEVQHTNPQRFRAIPLSEAVRTLREQYEVRIERLHETLADLELDAADQDVDAPEVWTVASEGTLDARIAETITGANDEAILVLGTANDWTPELQNAVEVAVDRGVSMHVVTIPGASIDLSDLDGVQTVESELPWLEGSGDDGQIGRLVLVDRDTLVLTTPPVDHSGGEQGIVAEGRTNGAVVLCRRLLRNELPASLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C7</accession>
    <name>R4W7C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02827">
        <property type="protein sequence ID" value="AGN02827"/>
        <property type="gene ID" value="L593_14440"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14440"/>
    <dbReference type="HOGENOM" id="CLU_2505104_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9489" checksum="7F8C3B97D238ABFE" modified="2013-07-24" version="1">MKSDGIRLDHAAHHTQTPIYGTEADRETGFPDSMNLREHDNRDDMKVWLSQADVAQLLDRADCPNSVLRSRSVRAVGSAPTRSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E6</accession>
    <name>R4W7E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445822.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04895"/>
    <dbReference type="EnsemblBacteria" id="AGN00928">
        <property type="protein sequence ID" value="AGN00928"/>
        <property type="gene ID" value="L593_04895"/>
    </dbReference>
    <dbReference type="GeneID" id="58789335"/>
    <dbReference type="KEGG" id="sali:L593_04895"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961754_0_0_2"/>
    <dbReference type="OrthoDB" id="75646at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="288" mass="31594" checksum="8548F3EB4F71D173" modified="2013-07-24" version="1">MTRGRAALTVDLETFEQLPAYRDANGTTDRTDVGLEVLDDLLALLDRHGATCTFFTVASIAEDHSDLIAEIADRGHEIASHTRSHRHLPDLAPDERREEITESRSILEHAAGTDVSGFRAPSFQRTDDSLELLADAGYEYDSSVVAARSIGWYGGGPKLHDPCPATAVDPDAPADLRELPVSVMPGLRLPLTGAWLRLFGIHYALAGMMLQARQGRAPVLYVHPWELADLPDVEGVPRRVTVRTGDWTWRALERILQQDVEFVTARTLAMDGAASESPPQPNDVEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G2</accession>
    <name>R4W7G2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447786.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14790"/>
    <dbReference type="EnsemblBacteria" id="AGN02892">
        <property type="protein sequence ID" value="AGN02892"/>
        <property type="gene ID" value="L593_14790"/>
    </dbReference>
    <dbReference type="GeneID" id="16181480"/>
    <dbReference type="KEGG" id="sali:L593_14790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3020"/>
    <dbReference type="eggNOG" id="arCOG04060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077869_0_0_2"/>
    <dbReference type="OrthoDB" id="55424at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="235" mass="25510" checksum="AE1AF921A7B70AA2" modified="2013-07-24" version="1">MGEGPRGELAEKIAGEVALSDDPGATLRKWRTDFDVTQTELAEILDISSSVISDYESGRRDSPGIAVVRRIVTGLLDIDERRGGDRIRQYGRVLSAGFESDVVLDLREYSAAISIDSVFDEIGAEGLVDGERDRITGHTVIDSVEAIQRLSSEEIFNLYGQSTSRVLIFTGLTRGESPLVAQRVVSPTPNAVVLHGIDEDELWEHAPDLARVDGFALATCTTPLETVLDGLESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R3</accession>
    <name>R4W7R3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1_PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444883.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00170"/>
    <dbReference type="EnsemblBacteria" id="AGM99988">
        <property type="protein sequence ID" value="AGM99988"/>
        <property type="gene ID" value="L593_00170"/>
    </dbReference>
    <dbReference type="GeneID" id="16181032"/>
    <dbReference type="KEGG" id="sali:L593_00170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.34"/>
    <dbReference type="eggNOG" id="arCOG00769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_2"/>
    <dbReference type="OrthoDB" id="58046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="230" mass="24740" checksum="6A31D5B8A03E9708" modified="2013-07-24" version="1">MPSALFVVSEHGYWGEECVEPLETLTEAGVEITVATPTGGAPEPDERSVDPDNVGEEQADHVTEVAKNDERLRNPVQITEVSAADFDAVVFPGGHGTEWDVNQDRHARTLLRDAVVGEDGKALVVCHAAGLLAFTRDADGEFLVDGRSVTGFPNDWEEGIVDDQDLMPDGRKLPYWVEDEVKAAGGDWDAELDQDTSVRVDGDLVTARGPSSSSRAAQTLLDELGIEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R5</accession>
    <name>R4W7R5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Triphosphoribosyl-dephospho-CoA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444888.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00195"/>
    <dbReference type="EnsemblBacteria" id="AGM99993">
        <property type="protein sequence ID" value="AGM99993"/>
        <property type="gene ID" value="L593_00195"/>
    </dbReference>
    <dbReference type="GeneID" id="16181110"/>
    <dbReference type="KEGG" id="sali:L593_00195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.39"/>
    <dbReference type="eggNOG" id="arCOG04238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063627_0_0_2"/>
    <dbReference type="OrthoDB" id="62406at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="29624" checksum="8E498BC37C8783A6" modified="2013-07-24" version="1">MSSPAALAERALLLEVAATPTPGNVDRERDLPDLRFEQFLAGATGARDGLERIAEGDAIADGFENAVACMAEASGTNTQFGSLLLLAPLLRASVRNDRLTPETASAAATATTVDDAAAFYRSFGHVDVRVDDPPADLEPLDVRRGSDAIPTLRDRGLTLADVMETAADRDGIAAEWTHGFERTFAAADRLATTDGPIGERAARVHLELLAAEPDTLVATKHDEATAAEVRRRAASIDPEDVDAVRDFSEELIDRGINPGTTADLLAGALFVALVRGEVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X9</accession>
    <name>R4W7X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00995"/>
    <dbReference type="EnsemblBacteria" id="AGN00154">
        <property type="protein sequence ID" value="AGN00154"/>
        <property type="gene ID" value="L593_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00995"/>
    <dbReference type="eggNOG" id="arCOG06347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056150_0_0_2"/>
    <dbReference type="OrthoDB" id="103176at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12955" checksum="477C6BB558803FB6" modified="2013-07-24" version="1">MDVNVLLPFEWRDGIAHRHLLGAGAGTLTMAEIGDHYRSVGAAAPTGTYRVVGTTDTVCLLRVTNEDGRRRHTGEVVRVSDGTLEDAFEPTTDPDAGIDPIGVLSNLLQGLYWSARRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W812</accession>
    <name>R4W812_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445103.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01280"/>
    <dbReference type="EnsemblBacteria" id="AGN00209">
        <property type="protein sequence ID" value="AGN00209"/>
        <property type="gene ID" value="L593_01280"/>
    </dbReference>
    <dbReference type="GeneID" id="16180269"/>
    <dbReference type="KEGG" id="sali:L593_01280"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_1_2_2"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="76" mass="8260" checksum="F4E439F6E5ED7D12" modified="2013-07-24" version="1">MVHAFVMVKTAAGTSEGLVDTLRTVSPVTEAHIVAGEYDIIAEVDVEKVYDVLDTVANEMRSLEGVADTRTYISMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A8</accession>
    <name>R4W8A8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_02640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445373.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02640"/>
    <dbReference type="EnsemblBacteria" id="AGN00479">
        <property type="protein sequence ID" value="AGN00479"/>
        <property type="gene ID" value="L593_02640"/>
    </dbReference>
    <dbReference type="GeneID" id="16180272"/>
    <dbReference type="KEGG" id="sali:L593_02640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.535"/>
    <dbReference type="eggNOG" id="arCOG04403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_2"/>
    <dbReference type="OrthoDB" id="22772at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="552"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="12">
        <location>
            <begin position="787"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="914" mass="94813" checksum="BC162A2185126DC7" modified="2013-07-24" version="1">MTESTRLQLFADESREKLTELNNALLTLEENASDTEALNQSFRSAHTIKGNSLAMGYESVGDLSHAVEDLLDEMRDDEVPVTPETIDLAFDGLDALEDAIGEIAADGEVQTDLQPAIERVRTGLEAHLDTPPAAANGGTSPDSAEPAESPAADVIEVTIDDPTLPGADALLVLQAMEAHGTIEETDPPRQALEDGEYDGGFLATVRGADFEALREAVAAEGSVTNVALVDSSEAPGDSADDTTSNSAGEGKPDSGGEGVPASADEDVPDSNGNGAPNSAAGAQTVSAAGAQTVSADGATAGSADGAGTAPADGSVGSSSDQAVSESTGEATAESTGDADRTEAEPARAGTSDESGSAATRESDRGLVGTVRSLLRSLDPRSGSGTGSGGASTTAGADTGGADVDAPLQAAGVESSAARSSAVAESDPADSDGTAAEPATEADHESDRAESSGAATDEADLSASETDGSERSSGAKTTTSATEKVNDEPTTDESRSAESAPSDSSTGGSSSDGTSIDDSPSDDDTTTSAGEETSDVDVGSVRVDVDRLDDLYGIVEQLFTTRIRLRRIVEAAGVDEAADQLDALDKNTDQLQDLVMDMRLVPLSRVVDRFPRTVRDLARDSGKEIDLEITGEDVEVDRVVLDEISDPLLHLVRNAVDHGIEPPDERADADKPREGTVSIRARRERDQVVVVVEDDGGGLDPATLRDRAVSEGIADRDTIDAMDDDEVQDLIFHPGFSTAEDVSEVSGRGVGMDVVRQRVRALDGSVELESEQGEGTTVTLRLPVTVAIVEVLFVDVGEATYGIPIKEIDRISRFEGVQEVNGRRSIEYQDDVYPVVALDDVFDETPTREGEDRRLVRIRPSRKRIALVCDAVHNHEEVVVKPLSGPLANTPGLSGTTVLGDGNVVPIVDVQSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D3</accession>
    <name>R4W8D3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02990"/>
    <dbReference type="EnsemblBacteria" id="AGN00549">
        <property type="protein sequence ID" value="AGN00549"/>
        <property type="gene ID" value="L593_02990"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.606"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="34743" checksum="3DB1CAE78DFB7BF3" modified="2013-07-24" version="1">MSVAMLALFVGFGLLIGILFGFFGMGGSFLVTPALLVMGYESSVAVGSGLAFVFGTSVIATLKHRDLGQVDYKLGVLMIAGTTAGIEVGKEIVLHLQELGLAGSVISVTYVVLLGGIGAFVTYEAIKGDGGGGVDHDVEDVDPDEDLSDDIPDIAKKIQSYHLPPMIDLRGGVSVSLWMILAVAFATGLLSGLLGVGGGFIRMPALFYLIGVPVPIAVGTDLFEIVFSGGIGSFLYAMDGGVNLGIVVPLLAGSALGARVGSAATSIVDEDEIKVYFGVMLLGGAVAVAVRQIGNATGIEELSIVSMVLILGSALLVSGAVVQSSLSALRESNRSGSTIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F1</accession>
    <name>R4W8F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b/b6 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445503.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03290"/>
    <dbReference type="EnsemblBacteria" id="AGN00609">
        <property type="protein sequence ID" value="AGN00609"/>
        <property type="gene ID" value="L593_03290"/>
    </dbReference>
    <dbReference type="GeneID" id="16180488"/>
    <dbReference type="KEGG" id="sali:L593_03290"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.666"/>
    <dbReference type="eggNOG" id="arCOG01721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057992_0_0_2"/>
    <dbReference type="OrthoDB" id="70323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="2">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="268" mass="30869" checksum="D3CA3207EFEB731E" modified="2013-07-24" version="1">MSLERTDEFDRGDWLQNKDLSRVERTYLVTLMWLDKRFRLVDYLELLEDAYYKTNLQMPKSHTEQYNLDNKFWYWYPLYSLGSLSIISYVLLAISGALLGFYYSPSATAAAGEEATIAYNQIVFIQTDLNFGFMLRSIHRWAAQFMVAAVFLHMIRVYFTGAYKEPRELNWILGVVLILLTLLFGYSGYVLPWNQLAFWAAQIGLEMALSVPLIGEWAAQLLFGGFSPGAPTLMRMYILHVFVLPFVVTSLIAIHVGIVWMQGIAEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J2</accession>
    <name>R4W8J2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_03665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445578.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03665"/>
    <dbReference type="EnsemblBacteria" id="AGN00684">
        <property type="protein sequence ID" value="AGN00684"/>
        <property type="gene ID" value="L593_03665"/>
    </dbReference>
    <dbReference type="GeneID" id="16180708"/>
    <dbReference type="KEGG" id="sali:L593_03665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.744"/>
    <dbReference type="eggNOG" id="arCOG00562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467441_0_0_2"/>
    <dbReference type="OrthoDB" id="12327at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="142"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="614" mass="66250" checksum="DAAC7E5C6F1C1EF0" modified="2013-07-24" version="1">MRLVPDLLLDNASPGDLRDRLRAAIRANPRLALLLVLGAPLFLYGIWRAQLYQMIPDERGAIMRPLLLVHGGPGISDFEKGGNLHVWILALFYIPVIVAFVAYYAATGKLGSVLDTAQTFQTYEDLWAAPASIQDPFFAIVVAGRFASALAGLLGVLGVALLARRLADDDRAGLLAGAALATTMGYVLTAHYATEDVLAGALLAWTFVFVARYTDLRTDRQLLLASAVAGLAISAKATNGLTALPIGAYAFARHDPRSFDLGSSDGRRSFGRAIGRYPAAAIATYVVTTPSLFLHPGAWLGELGRYFGKVSGESTFYASPDSGLVSHTGNLIGAMGVPLFLLAVVSLVGVVALAATDRIDRTALAPVTFVVPYFLIITSWQNVQYNRALLLTPLLAVFVGVFGAWLLSLDRPVLGRSGVRGLTVRRIAAPVLAVVLLLSLVYTGIGVASFNQSRAEATEWTHANFDADTDVAVIGQRIYLPAFPEETNVSRTEILMENDPATWQEGLARVRCNQHEYLVLTSFQYTRHFQDPTVLPEVAETYRSLLNEEDYEIVRTFGPDVNRNNDAAGMVENALRLQPPAKNVGNPRILVLQRTAEPAESCPELANGSAASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R8</accession>
    <name>R4W8R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446927.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10440"/>
    <dbReference type="EnsemblBacteria" id="AGN02033">
        <property type="protein sequence ID" value="AGN02033"/>
        <property type="gene ID" value="L593_10440"/>
    </dbReference>
    <dbReference type="GeneID" id="16180900"/>
    <dbReference type="KEGG" id="sali:L593_10440"/>
    <dbReference type="eggNOG" id="arCOG10216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="168" mass="17754" checksum="B001D87F8E2E82B2" modified="2013-07-24" version="1">MIRVVVTVLLAIALLAAALPAVEDAAADRIERQLRADIEAIDTAATELLRSEEAVPGTAGARRTVSVTLAADGIAAAPVEEVRISSTDRRYSFRVEGRGERKLRGTVPVHTLGDEPLVLREPGTHELVLALVRVEGERRVVIARIEAVRDGALGGTRASATGPPGVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U6</accession>
    <name>R4W8U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_10765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446992.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10765"/>
    <dbReference type="EnsemblBacteria" id="AGN02098">
        <property type="protein sequence ID" value="AGN02098"/>
        <property type="gene ID" value="L593_10765"/>
    </dbReference>
    <dbReference type="GeneID" id="16182343"/>
    <dbReference type="KEGG" id="sali:L593_10765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2219"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OrthoDB" id="121393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11962" checksum="2ABD8C7884737E91" modified="2013-07-24" version="1">MQFCDECGSMMKAEDGVWVCGSCGYEEARDSDAEAAMVTTEGQEESQVVDTSDVDVEDMGPTTGAICPECGNDRAFWEMKQIRAADESETRFLTCTECEHKWREDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X9</accession>
    <name>R4W8X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium transport system protein trkH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445923.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05400"/>
    <dbReference type="EnsemblBacteria" id="AGN01029">
        <property type="protein sequence ID" value="AGN01029"/>
        <property type="gene ID" value="L593_05400"/>
    </dbReference>
    <dbReference type="GeneID" id="16179883"/>
    <dbReference type="KEGG" id="sali:L593_05400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1103"/>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_3_0_2"/>
    <dbReference type="OrthoDB" id="13996at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="516" mass="55837" checksum="0C5B503963AC958B" modified="2013-07-24" version="1">MSGAAATIGRDVGRILEALGGLMIVSVLVTLAWGEYFALPALLVSAVVPLGIGRFLYRRYRSADAPGRLHGMIVAAAGWLFVGLFGSLPFLLVAWSVELGVPIVSTPQQTATLAAFTNPLNAIFESMSGFTGTGLTMTDDESALPRTLQWWRTFSEWVGGVGVIVLTTAILSRPGSGSLTLYESEARSEKIHPSVVSTVRTIWWIFILFTFGAILTLWLAGMPIWGAINHAMTGLSTGGFSITDNSIATYDSVAIDFALIPIMLLGSIAFPVHYLILQGDLRNFYSDLQTRWVFLYMSTGSALLWGLLYFAGPYETPFAALRYGLFQFVSAATCTGFQTAVDATNVAIGRWPSYAQLTVTFGMFVGGAAGSTVGGIKIIRGLTLAKGIRYQISEVFYPESAVRRLVINGRRLNDEASSREFMEAAIVFVLWVTFLVVGTFVLLLALPADDYTLPNVFFEVASAQGNVGLSSGITGPDSLPTIGKVTFLFHMWIGRLEIIPVLVMLRTVFQRGGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W999</accession>
    <name>R4W999_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446198.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06785"/>
    <dbReference type="EnsemblBacteria" id="AGN01304">
        <property type="protein sequence ID" value="AGN01304"/>
        <property type="gene ID" value="L593_06785"/>
    </dbReference>
    <dbReference type="GeneID" id="16181873"/>
    <dbReference type="KEGG" id="sali:L593_06785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1386"/>
    <dbReference type="eggNOG" id="arCOG02292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154322_0_0_2"/>
    <dbReference type="OrthoDB" id="79753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="245" mass="26409" checksum="7775AB91D3BD5672" modified="2013-07-24" version="1">MAGHAYDAVLFDLDGTLVAPEFDHVRSVFDAVGRQLDHHFSDEIASRLWHGLGGPRNEQLRELGVDVAEFWRVFDATEDPQDRAAAMEVFDDAAIAADLDVPTALVTHCPPKPTAAVLDHHGIGEWFDAVVSCSDDLGWKPDPGPIEHALGEIGMDHLVDDRRDGRIAADGGTPITAGPGAAAEPPSRALYVGDTAGDVGAAWNAGLDAVHVERFDHDRREHCVLADYRVDAIDRVDPLRSMAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A5</accession>
    <name>R4W9A5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">L593_12870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447407.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12870"/>
    <dbReference type="EnsemblBacteria" id="AGN02513">
        <property type="protein sequence ID" value="AGN02513"/>
        <property type="gene ID" value="L593_12870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180218"/>
    <dbReference type="KEGG" id="sali:L593_12870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2639"/>
    <dbReference type="eggNOG" id="arCOG04133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_2"/>
    <dbReference type="OrthoDB" id="50229at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="318"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="43785" checksum="8DCCF39825C147C1" modified="2013-07-24" version="1">MNGNSFGRLFQVTTYGESHGPAMGCTVSGCPAGVELDEERIQRELDRRKPGQSMITTSRGEPDEVTINSGVLEGYTTGTPIGMVIQNKDARSGKYEPFVTAPRPSHGDYTYSAKFGTRNWGGGGRSSARETVNWVAAGAIAKEVLDQSEYDVTVKGHVNQIDDIEAPDVTWEEMLEHTEENEVRCADPDTAEEMREHLEEVQQHGDSVGGSVYFECRGVPRGLGAPRFDSFAARLGRMVFSIPATTAFEYGVGKAARSMKGHDRNEDWEAYDPEAGDSARGGEVVAEEGDPVPVGNDHGGLQGGITTGEPIYGEISWHAPVSIPKEQTTVDWETGEEKTIQVTGRHDPSLPPRAVPVVEAMFYCTILDFMLLGGRINPDRLDGRPGEYDTEYHPSSPRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C1</accession>
    <name>R4W9C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde reductase/aldo/keto reductase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447442.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13045"/>
    <dbReference type="EnsemblBacteria" id="AGN02548">
        <property type="protein sequence ID" value="AGN02548"/>
        <property type="gene ID" value="L593_13045"/>
    </dbReference>
    <dbReference type="GeneID" id="16181633"/>
    <dbReference type="KEGG" id="sali:L593_13045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2674"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="29877" checksum="62DD3A2E130D7B98" modified="2013-07-24" version="1">MTRDPTPIGFGTWQNEDPEQCAESVKNALEMGYRHIDTAQGYDNEDAVGDGIAAADVDRDDIFLATKVDTGDLGHDDVLRTTEESLEKLGVDTIDLLYVHWPLDAYDPEGTLSAFDELVDRGDIRHVGLSNFNPEQLAEAREILDAPIFAHQVECHPYCQQEEHLALAEEHDYHLVAYSPLAQTEVFDDPVIQEVAEDQDASPAQVCLAWLRQRGAVAIPKATSYEHIEDNYGSLEVDLSDDAMERIDSIEEEYRVVDFDGAPWDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C2</accession>
    <name>R4W9C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01369">
        <property type="protein sequence ID" value="AGN01369"/>
        <property type="gene ID" value="L593_07110"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07110"/>
    <dbReference type="eggNOG" id="arCOG10718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3322824_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="41" mass="4410" checksum="0FC5F0D37A20D509" modified="2013-07-24" version="1">MSQFETFECRNCGKSFVALPEANAGTKRLCSPACETAQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F5</accession>
    <name>R4W9F5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446358.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07595"/>
    <dbReference type="EnsemblBacteria" id="AGN01464">
        <property type="protein sequence ID" value="AGN01464"/>
        <property type="gene ID" value="L593_07595"/>
    </dbReference>
    <dbReference type="GeneID" id="16182161"/>
    <dbReference type="KEGG" id="sali:L593_07595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1556"/>
    <dbReference type="eggNOG" id="arCOG03110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047250_1_1_2"/>
    <dbReference type="OrthoDB" id="55690at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="139"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="42598" checksum="A1AFB733AA92A0AD" modified="2013-07-24" version="1">MDTTDFADGPGSFDDYDGLACHRPPTLPPDLTYTDDLFDVYGDAQYALGRLATLHRDLDNPTLLIAPFVHREAAMSSQVEGTNVTISDIYQHEVDAEPARSAAEHADVREAYNYVDAISAGFDHLDGADEGRGDGGGSIDVDLVRELHERLLGGVRGEADAPGELRDVPVYIGSPDGTPETAAFIPASPDVVEILLDQLLAYVRRGEYPPVVDVAIAHYQFEAIHPFRDGNGRLGRLLMMLQLYDAGLLPGPYLYLSAYFKRHGDEYRDRLLAVSQEGDWEGWCTFVLDAIAEQAIDAHDCGIELTDLREDYRSRFPASPVARELVDYVFEQPYLTGPRAVEATDRSKPAVYDAIEALEAEGIVTETTGKQRNKVYEASAVLDVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H5</accession>
    <name>R4W9H5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="11" type="ORF">L593_07870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446413.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07870"/>
    <dbReference type="EnsemblBacteria" id="AGN01519">
        <property type="protein sequence ID" value="AGN01519"/>
        <property type="gene ID" value="L593_07870"/>
    </dbReference>
    <dbReference type="GeneID" id="16182245"/>
    <dbReference type="KEGG" id="sali:L593_07870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1612"/>
    <dbReference type="eggNOG" id="arCOG00112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_0_2"/>
    <dbReference type="OrthoDB" id="49443at2157"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
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    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
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        </location>
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        </ligand>
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        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
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        <location>
            <position position="264"/>
        </location>
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        </ligand>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="410" mass="44631" checksum="67C42A40DDE0D9A9" modified="2013-07-24" version="1">MSRVALAFSGGLDTTVCVPLLEEEYGYDEVIGVTVDVGQPDSEFEEAEETAEALGLDLHVVDAKDEFADLCLDAVAANATYQGYPLGTALARPVIAEAILEVAEEEDCDGIAHGCTGKGNDQLRFEAVWRGSDLEVIAPVRELGLTREWEIEFADERDLPVEAGDGGVWSIDQNLWSRAIEGGELEHPNYVPPEDIYQWTEEPDGGTELIEVEFEQGVPVAVDGEAMEPVELIEYLNEHAGQYGVGRTDVMEDRMLGLKVRENYEHPAATVLLAAHQALEDLVLTKEERSFKKGIEHEWAEKAYEGLVFAPLVDALDAFVQETQDVVTGTATVKVQGGSCRAVARDSEYAVYSEEMASFNTEDVAGIAQEDATGVAKYHGLQERLANSVKAEALDRSPAVTDGGESENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P1</accession>
    <name>R4W9P1_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Putative signal-transducing histidine kinase / response regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">L593_14520</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="gene ID" value="L593_14520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180510"/>
    <dbReference type="KEGG" id="sali:L593_14520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2969"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAF"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
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        <property type="entry name" value="PAS-like_dom_sf"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="381"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="445"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="646" mass="69663" checksum="C0355409DD541C8B" modified="2013-07-24" version="1">MTSRVLCLSDDAAFASRISAPLEYSYPEVSVLSVDDVAEGVEVVRTEHVDAVVTDAATIAAAPALLEAVRSRRPELSLLVLSTYETGGEHRTAVAEVVDFLDGVGSADDGALADWVANSVVDDGDAPVPGAASQLDTVVAGIKRELVDATRPGDVESAVCERLVLADQYAFAWIGEFDRGEGQVVPWGTAAADGDWPRSRTFPAGDDVDGVVAEVLRTRRPTVVDDVEGYGPPVPWREASLERDCESLVFVPLQTEEELFGVLGVYSTDPEGVDVPEQEALVEVADTTARVLEGMAIRGRIDQQERILRRYERLVETVGDGMYALDAEGHFMTVNDALCAMTGYAREGLLGEHIDTILDADAARSWSEAVESLQGTAGESRSLELTVETKHCDTFPCENKVGLLPSDEDGVPRGTVGVLRDITERKERERALHRQNERLDAFASIVSHDLRNPLSVAQGYLEHVAESTADQESVARVEESLDRMNELIDDVLALARGGETVTDTSPVHLSTAVRSAWSNVDTRGASLDVSADVKIEAADSRLLRLFENLFRNAIEHGGEDVTVTVGVLETTDPDTVGLYVEDNGPGIPPDVRDHVFESQFTTSERGNGIGLWVVSEVADAHDWTATACVGSEGGARFEFAQIERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R4</accession>
    <name>R4W9R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447822.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14970"/>
    <dbReference type="EnsemblBacteria" id="AGN02928">
        <property type="protein sequence ID" value="AGN02928"/>
        <property type="gene ID" value="L593_14970"/>
    </dbReference>
    <dbReference type="GeneID" id="16181607"/>
    <dbReference type="KEGG" id="sali:L593_14970"/>
    <dbReference type="eggNOG" id="arCOG01463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_2"/>
    <dbReference type="OrthoDB" id="71648at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="413" mass="43782" checksum="ED230228299077D8" modified="2013-07-24" version="1">MRRVGAIVVALGKNWLRSREAVFFSLVFPIVLLLIFSSVFAGGGSAEFTVYLQNNDVEDGTATNLSAAFVESLEESDALRVRTIDADRDLDEWSESSDADGPSRVLVIHDGFAERVRASAGRAQADVTMATLERLGPGLPDGTQQSVTEALRNGSTAGAGTPPANLTLLTAPDDNTAAAIRGIVGSYVAAFNERAVGVEQSPTTIRSGEIGDESLGAVDYFLPALIAAVMLINGVITLTGSVARYNTDGTLKRLASTPLRRWEWIVGHLLLQALLAIVITALMVGVAHLVFDVTVIPGVASMALILLAAMAFSAIGLTLGGLVSDQDAATSLGNAIAFPVLFLSGVFWDVELMPEYLQQVAELLPLYHLHRALRQLMVVGATEGVPLAVGSLGLLTVVFLGAAIRITRWRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S2</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="10531" checksum="D662A17FAD1C106C" modified="2013-07-24" version="1">MDLFQHPAFDIADAKLRFYWKHDPRCLDLDSGLDRHREPIWRDVRRRDRAVGPDRPSQPLDRIDDVQAMVDPEGLRDERPGRMGVSHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V8</accession>
    <name>R4W9V8_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_09670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1991"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="255" mass="27035" checksum="7FE8A44DB813E522" modified="2013-07-24" version="1">MIDVDCSGRTVLVTGSARGLGRATALAFAERGAAVAIHYNTSEDAAAEAVTQARDAGAADAIAVGADVTDPDEVERLFEQIEADLGPVDVLVNNVGAFAPTHWEEIDHETWQRVFATNLHATYLCSKRALPAMREQPAADADGASAGGRIVNIGYASAEKGLVSPKNFPYFAAKAGVLMFTRMLAADTSDDGVTVNAVSPYVIENSDEFPDDLPRGRPAAYEDVVQAILFFCHPDSDYLSGENVEVDGGWLPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W2</accession>
    <name>R4W9W2_9EURY</name>
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        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01899">
        <property type="protein sequence ID" value="AGN01899"/>
        <property type="gene ID" value="L593_09770"/>
    </dbReference>
    <dbReference type="GeneID" id="16182653"/>
    <dbReference type="KEGG" id="sali:L593_09770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2011"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54999"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="domain" description="Ribosomal_S10" evidence="6">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="11502" checksum="EFF0DCF26B616DB0" modified="2013-07-24" version="1">MQQARVRLAGTSPEDLDDICDDVREIADKTGVTLSGPVPLPTKTLEIPSRKSPDGEGTATWEHWEMRVHKRLIDLDADERALRQLMRIEVPNDVSIEIVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W3</accession>
    <name>R4W9W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coenzyme F420-dependent oxidoreductase, NP1902A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446798.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09795"/>
    <dbReference type="EnsemblBacteria" id="AGN01904">
        <property type="protein sequence ID" value="AGN01904"/>
        <property type="gene ID" value="L593_09795"/>
    </dbReference>
    <dbReference type="GeneID" id="16182811"/>
    <dbReference type="KEGG" id="sali:L593_09795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2016"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_2"/>
    <dbReference type="OrthoDB" id="48011at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023909">
        <property type="entry name" value="F420_NP1902A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04024">
        <property type="entry name" value="F420_NP1902A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="37126" checksum="886709F1D27A0B45" modified="2013-07-24" version="1">MGFGTKRTFVTDLDVHLPVADLPIDDVAELTRRSERLGYDFVWQPETWGSNGVAAMTVMAERTDEIGIGSSILNVYSRSPALLGQSAATLQEHSGGRFRLGIGPSGPILIEGWHGVDFERPLRRTREALEIIRAVTAGETVNYDGDVFSLSGFRFRSEPPADAPPVDVAAMGPKGVEMAGRFADGWHGIVLGPGGIRDRLEDLERGAELGDRSPDDVRTQISVPTCVHEDGDRARDLVREHMAFYVGGMGTYYRDALARQGHEDTAMEIAAEWANGNKKEAAALVSDDILDEFAAAGTREEARADLQRFTEIDGVDAVSIGFPHRASLDRVRDTLHALAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W8</accession>
    <name>R4W9W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446823.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09920"/>
    <dbReference type="EnsemblBacteria" id="AGN01929">
        <property type="protein sequence ID" value="AGN01929"/>
        <property type="gene ID" value="L593_09920"/>
    </dbReference>
    <dbReference type="GeneID" id="16182858"/>
    <dbReference type="KEGG" id="sali:L593_09920"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_6_2"/>
    <dbReference type="OrthoDB" id="29058at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="176"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="31324" checksum="783CFF51BA7895E6" modified="2013-07-24" version="1">MTDLVVSIDWLAERILDEEGAPAEDPPVRVVDVRDAWEYDGMGHLPTAINVQFDAFRSEDGLDDGDEVGHLPGAEAFADLLGEHGLTREDTIIAYDDTNGVFAARFLVTALVYGFEDVHLLDGDLSAWRQQYPISNEGVDLPTTDVEPVRVEGEDSPLVDADDVRAAIDGGAGPEPDANSVLLDTRDQFEFDEGHIPGAVRFDWQEAVDAETRGVKSRETLEELFAERGVTPDKRVLLYCNTARRLSHTYVVLRWLGFEDVGIYEGSLTEWREIGGELVSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA25</accession>
    <name>R4WA25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447108.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11345"/>
    <dbReference type="EnsemblBacteria" id="AGN02214">
        <property type="protein sequence ID" value="AGN02214"/>
        <property type="gene ID" value="L593_11345"/>
    </dbReference>
    <dbReference type="GeneID" id="58789374"/>
    <dbReference type="KEGG" id="sali:L593_11345"/>
    <dbReference type="eggNOG" id="arCOG09177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071509_0_0_2"/>
    <dbReference type="OrthoDB" id="75646at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="34580" checksum="AFF010938B314239" modified="2013-07-24" version="1">MGTVVISVDAALGWSCIDRQSPPVERVEAARSGWRTLLDRFDDHDLPATWGVVGHLLLEHCDGVHEHHPLSPGWFDREREAWEDCPELRFAPNLVEETVDAPAGHEFAFMPFSHVEFGHDEVSSDLARAECVGFFDALPDDLPSPRTATFPCNAVGHRAVLAEWGFECYRGRIPGRATQLPIARSARRLANATVAGPPIVRPTVDEYGLVALPTSLDCSAAQSAAGRLYSRAITDPTLAAVHRGLERVAASDDGVFHCRLRPIDVIDDRDESRLESFCRAVADYRDDEGVDVATVGTVAERARSAPPSRWSHPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA31</accession>
    <name>R4WA31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447138.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11505"/>
    <dbReference type="EnsemblBacteria" id="AGN02244">
        <property type="protein sequence ID" value="AGN02244"/>
        <property type="gene ID" value="L593_11505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182356"/>
    <dbReference type="KEGG" id="sali:L593_11505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2372"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="31210" checksum="E5B8D96404D12C04" modified="2013-07-24" version="1">MPANESGTFDIGGDLTVHRLGFGAMRLTGENIIGRPNDEAEARRVVQRALDLGVDVIDTADSYGPGVSERILREAIEAHDEYDQDDVVLATKAGLLREAGGEWLKHGDPDYVRNQVLVSRDRLGVDTIDLYQYHRPDPDVDFEEAVQTFAELKDDGFVEHIGLSNVSVEQLERARDVVEIATVQNQYNVGNREDEAVLEACEDAGIGFIPWFPLGGGDLGSKESVVADVAEAHDATPQQIALAWLLEHSPVILPIPGTSSVEHLEQNVAASQIELTDEEYARLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA37</accession>
    <name>R4WA37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02274">
        <property type="protein sequence ID" value="AGN02274"/>
        <property type="gene ID" value="L593_11655"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2402"/>
    <dbReference type="eggNOG" id="arCOG08131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061327_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="37805" checksum="A5A2D76D49F14E62" modified="2013-07-24" version="1">MTGRRLSVTLALMLAVFVTILALALLDPVKVHDLFDEKTAGQQLFTALLSGAILLVSIVVSINSVTLSEEITDLENQEQRIQATLDYHRRIEEYIEAEVTPARPADFLTAVLYGLDQQAEVLEETVDAGGNERLKEDVAALTSGISTDVLQARRRLEAAEWGTFDVLLAGLNYDYSSHLHAVRGLRHEHGDALSDEERQALEGVVDVLTHIGTSREYFKSLYYKRELALLSSRLLYVGLPVIVFTSYVILALDAQLFPQVSMFGLSPVLLSVAFAFTVALAPYLVLTSYVLRATAVTLQTLAAGPFILHDGSNIEGLDWEVSGDGREWTAVGGHEQLSEELDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA44</accession>
    <name>R4WA44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447203.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11830"/>
    <dbReference type="EnsemblBacteria" id="AGN02309">
        <property type="protein sequence ID" value="AGN02309"/>
        <property type="gene ID" value="L593_11830"/>
    </dbReference>
    <dbReference type="GeneID" id="16182330"/>
    <dbReference type="KEGG" id="sali:L593_11830"/>
    <dbReference type="eggNOG" id="arCOG04563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550131_0_0_2"/>
    <dbReference type="OrthoDB" id="113137at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043854">
        <property type="entry name" value="DUF5816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19133">
        <property type="entry name" value="DUF5816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8815" checksum="9E6CACF5C387E622" modified="2013-07-24" version="1">MDTVTDGEGETLYVATDEGDRGSRGPFYVAYRDPERARRYGWVCGACGSLDAMMDTMGRIECDNCGNQRKPTEWDAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA65</accession>
    <name>R4WA65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Raf kinase inhibitor-like protein, YbhB/YbcL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12375"/>
    <dbReference type="EnsemblBacteria" id="AGN02414">
        <property type="protein sequence ID" value="AGN02414"/>
        <property type="gene ID" value="L593_12375"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12375"/>
    <dbReference type="eggNOG" id="arCOG04702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21312" checksum="C508F7B6D7A93B5E" modified="2013-07-24" version="1">MLAGCVDGDDGGDGSDGGGGSDDGNGQRADDASEDTDGSTDDRNPARGELQQRGDLSLTSPAFEDGGEIPAKYGLDGENVNPPLEIENVPNDAGSLALVVDDPDAVEPTGQVWLHWIVWNVAPERRAIPEDWTPEDAEEGRNDSGEIGYSGPSPPDRAHRYRFKLFALDATLDLPVATDATALGEAMAGHVLAQTQLDGTFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA84</accession>
    <name>R4WA84_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pilin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447403.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12850"/>
    <dbReference type="EnsemblBacteria" id="AGN02509">
        <property type="protein sequence ID" value="AGN02509"/>
        <property type="gene ID" value="L593_12850"/>
    </dbReference>
    <dbReference type="GeneID" id="16180143"/>
    <dbReference type="KEGG" id="sali:L593_12850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2635"/>
    <dbReference type="eggNOG" id="arCOG02416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116126_0_0_2"/>
    <dbReference type="OrthoDB" id="110213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="16005" checksum="E37A762388409CAC" modified="2013-07-24" version="1">MELRALYREDDAVSSVLGVVLMVAVTIVLAAVIGTFVLGIGSDLTDSSPNAQWEFSENLDGNGTSGSVVVLHGGGDDVKKSTLEVTVGGTTVFEDGSDASGNGYNVNDNWGDPITTGDRLRIEENTAQLSQGQAVRIIWSSGDSSAILADEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB1</accession>
    <name>R4WAB1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rpoH</name>
        <name evidence="2" type="synonym">rpo5</name>
        <name evidence="4" type="ORF">L593_13525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447538.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13525"/>
    <dbReference type="EnsemblBacteria" id="AGN02644">
        <property type="protein sequence ID" value="AGN02644"/>
        <property type="gene ID" value="L593_13525"/>
    </dbReference>
    <dbReference type="GeneID" id="16182004"/>
    <dbReference type="KEGG" id="sali:L593_13525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2769"/>
    <dbReference type="eggNOG" id="arCOG04258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_4_0_2"/>
    <dbReference type="OrthoDB" id="123463at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="SSF55287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb5_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="8500" checksum="DE09F391D7552C2B" modified="2013-07-24" version="1">MVDVSQHELVPEHEVVDEDVLDDVLEEYDIKRTDLPKIKRSDPALPAAAEVGDVIQIVRDSRTTDRAVTYRLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSS6</accession>
    <name>R4VSS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445124.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01385"/>
    <dbReference type="EnsemblBacteria" id="AGN00230">
        <property type="protein sequence ID" value="AGN00230"/>
        <property type="gene ID" value="L593_01385"/>
    </dbReference>
    <dbReference type="GeneID" id="16182581"/>
    <dbReference type="KEGG" id="sali:L593_01385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.282"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OrthoDB" id="72076at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="20396" checksum="31604406C0013B70" modified="2013-07-24" version="1">MTPERDLAARRGQTETVYQPAEDSRLLATAAIEHLGPDDRVVEVGTGSGYVAATIAQETGADVIGTDLNPDACEQTRERGVEALRANLLDPFAADSFDAVVCNPPYLPTEPDEERSDWMEVALSGGESGLAVIEPLLADVGRALRPDGVVLLLVSSLTGVDDVVELASAAGFSAAAVAEDSFPFETLSVLKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT80</accession>
    <name>R4VT80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445309.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02320"/>
    <dbReference type="EnsemblBacteria" id="AGN00415">
        <property type="protein sequence ID" value="AGN00415"/>
        <property type="gene ID" value="L593_02320"/>
    </dbReference>
    <dbReference type="GeneID" id="16181290"/>
    <dbReference type="KEGG" id="sali:L593_02320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.470"/>
    <dbReference type="eggNOG" id="arCOG01054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_2"/>
    <dbReference type="OrthoDB" id="46312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="2">
        <location>
            <begin position="44"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="41651" checksum="87BB5DE39198279A" modified="2013-07-24" version="1">MDAADLLDRPHDDPLTLLSADGELAAGYEPDLTDDELVALYADMRLYRRFDERCVSLQRQGRMGTYAPLAGQEAAQVGTTYAFAPEDWMVYQYREHGIPLSRGVVGGYLQYWMGHEAGNATLADATVLPLNISIGSQVPHAAGLGMAIDYEDDDAVVCCQFGDGATSEGDVHEGLNFASVFDAPVVFVCNNNQWAISVPREDQTASATIAQKAQAYGFRGIQVDGMDPLAVYETTRAAAEQARDPDPALVDEAVGRASKPILIETLTYRYGAHTTADDPSAYRDEAEVERWKELDPIDRMETFLRRTGRLDGDRIDGIESRIEETVAEAIDAAEAVEADPLSMFEHVYEEQPARLGEQHRELATLRERHGDDALTRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTD9</accession>
    <name>R4VTD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis-specific methylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02645"/>
    <dbReference type="EnsemblBacteria" id="AGN00480">
        <property type="protein sequence ID" value="AGN00480"/>
        <property type="gene ID" value="L593_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02645"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.536"/>
    <dbReference type="eggNOG" id="arCOG02382">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843638_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="33358" checksum="69C7DC606B2FE215" modified="2013-07-24" version="1">MALATVLEDEGFSVAATPRTLSATIEAVRMHDPTVAVVAAGLPGADHPVDRLAGTTDVPIVSIARGSPAPRGATAVVRTEGDGVLGVTDGTSAVVEAATRVAVEASEPRWADVTAGPGTDRFEPVPVGNRRLPPAPTLVVGASTGGPSLVQRLLAELPPEAGFRVVVVQHMRDGFEERFAKRLDACSQYAVRTSEEATALDPGMAIVAASGSHVRIVDDADDTITLEVAAEPPMHGVRPAIDPAFSSAARVVAPHRLSAVLLTGMGADGVEGIRAVGKAGGLTVAQDPEEATVDSMPGGAIATGAVDAVATVDEIVESVLDGLDRSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUV1</accession>
    <name>R4VUV1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445904.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05305"/>
    <dbReference type="EnsemblBacteria" id="AGN01010">
        <property type="protein sequence ID" value="AGN01010"/>
        <property type="gene ID" value="L593_05305"/>
    </dbReference>
    <dbReference type="GeneID" id="16181315"/>
    <dbReference type="KEGG" id="sali:L593_05305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1083"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_1_0_2"/>
    <dbReference type="OrthoDB" id="62777at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="235" mass="27227" checksum="D6A6ADAD96827CF1" modified="2013-07-24" version="1">MGVEIKERRVSEEEFAAMEEFVFEYLAASVEREEEGGRMRWYPWHSAEYRYNHIRNVVDLAAEIARKEGADVDVTRVAALFHDVAKLDAEQDVHAEEGARVARQYLETHCDYPESFLDEVCRSIEDHSYQGPLEDLSLETQCLIEADLLDKVGANGAVLMMLRMGYEARTHMDAAEMVERVLERGHEAEERIRSDAAESVVHRRLKRVRWLREWLTEELSNVDPRSAEGPVDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUY0</accession>
    <name>R4VUY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444970.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00605"/>
    <dbReference type="EnsemblBacteria" id="AGN00076">
        <property type="protein sequence ID" value="AGN00076"/>
        <property type="gene ID" value="L593_00605"/>
    </dbReference>
    <dbReference type="GeneID" id="16181528"/>
    <dbReference type="KEGG" id="sali:L593_00605"/>
    <dbReference type="eggNOG" id="arCOG01902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_2"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="26716" checksum="09A75B284967B4B5" modified="2013-07-24" version="1">MAKTAIQLYTLRDVDLPFDELLEAVADAGFDGVEFAYRVPDEDPEEVRAVLDETGLEAAGAHVHLEDLEDDFEDTVAFYETLGVENFVIPWLDEEYFTSREGLDEAIERLSAVADDLAEEGYTLHYHNHDQEYSDYDGEPGFYTFIDESDFGLELDLGFVLIGGDDPAGRLRAVGDRCSLAHVKDVDADAGHSVPVGDGDVDIDAAAEAFAEIDGEWLIYEYEGDDPLESLDDAAATMRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV00</accession>
    <name>R4VV00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hef nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445964.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05605"/>
    <dbReference type="EnsemblBacteria" id="AGN01070">
        <property type="protein sequence ID" value="AGN01070"/>
        <property type="gene ID" value="L593_05605"/>
    </dbReference>
    <dbReference type="GeneID" id="16181518"/>
    <dbReference type="KEGG" id="sali:L593_05605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1146"/>
    <dbReference type="eggNOG" id="arCOG00872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_3_1_2"/>
    <dbReference type="OrthoDB" id="3323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12089">
        <property type="entry name" value="Hef_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041755">
        <property type="entry name" value="Hef_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="354"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="897" mass="98409" checksum="4629C42E62312664" modified="2013-07-24" version="1">MTDGESVATIEHPMLVDGMLERRRYQLQLAGRAMDGHTLVCLPTGLGKTAVSLVVTARRLHEVGGKALLLAPTKPLVEQHAEFYREALEIPDEEIVVFTGKVRPDDRAELWEDARVVIATPQVVENDLIGNRIDLADVTHLTFDECHRGTGDYAYVYIAERYHEDAEQPLVTGMSASPGGDEEEILTVCANLGLRQVEVMTEDDADVDRFTHDTDVEWDTVELPEELIEIRDALADVIEERLERLRELGVTKKRSADLSQRDLNELRGKLQNLIDQDKSEGYEGMSIHAEIMKLRRALEVVETQSIEAVERYFERQRQQARSSGASKASQRFVSDPTIREAIRRVEDFDERHPKFREAHLRLAETLGIEDGERAIVFTESRDTAEVLTEFLGEHFDTRRFVGQGDKDGSDGMTQKEQQETLDAFRAGEFEVLVSTSVAEEGLDVPEVDLVLFYEPVPTAIRSIQRKGRTGRQAKGKVVVLMAEDTRDEAFFWIAKRREEEMADELAELKAMTDELDARLEQAGLDAFATGDAPEAVPAGGAGATPEIAESRTGDGSDDGSEEGSDETPVSTGPSSTEGLTDETAEKPAADGVRRASDGAGSDGKSQASDGGEAEGQADLGSFDASDDAEDGSVPDDTTPHATAETEGFEAVAGSEAAVDETEGDEDEREGTVAAPDPEADAIEVVIDQRELESSIARDLSRKDEIETRLETLAVGDYVCSDRVAVERKTVEDFLDTLLGGDRSLFEQAGDLTRHYERSVVILEGEGVYERRDVHPNAIRGALTSLAVDYGLSIMHSDDPDETVELLATIAGREQADRDREVSVHGEKQSKTLGEQQEYVVASIAEIGPVTARALLAHFGSVRDVMTADEEELLEVDGVGQVTVERILEVVTSEYTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV60</accession>
    <name>R4VV60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_01005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445050.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01005"/>
    <dbReference type="EnsemblBacteria" id="AGN00156">
        <property type="protein sequence ID" value="AGN00156"/>
        <property type="gene ID" value="L593_01005"/>
    </dbReference>
    <dbReference type="GeneID" id="16181693"/>
    <dbReference type="KEGG" id="sali:L593_01005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.206"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OrthoDB" id="42527at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="493" mass="52592" checksum="9BCD3727BDDD6266" modified="2013-07-24" version="1">MATPEQQTESGWDRMYVDGEWREASGGDTMPVENPATREPFTEVPAATAADVDAAYEAAAAAQPEWAAKSREERLEYVQAAHDHLQERFEEVVGLLAREGGSAQNKATGEVAISLSDFKTALQQEPPADEERESAFFGESKTHHIVQEPVGVVGIISPWNYPLHLSTRALAPALALGNTVVLKPATDTPITGGLLLAEIADEVGFPDGVVNVVTGRGSEIGDRMAGHPVPRVLSFTGSTSVGKSVASAAGSTVTLPALELGGNAPNVVTEDVDVEQAAKIGAVGSFTHQGQVCISINRHLVHEDVYDEYVELLAEHAESLAVGDPSENPAVDFGPVVNETQRDDLLEFVEQSVDEGATLETGGDADGLFVEPTVLSDATNDMAAACDEHFGPIAPVIPISGDEEAIELANDTEYGLSAAVQCDDVERARSIADRIDAGMVHVNDHPIQDEPNAPFGGMKQSGLGRYNGEWIVDELLETKWISVQHEEREYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV96</accession>
    <name>R4VV96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01155">
        <property type="protein sequence ID" value="AGN01155"/>
        <property type="gene ID" value="L593_06030"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06030"/>
    <dbReference type="HOGENOM" id="CLU_722833_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41915" checksum="B3C5874345AD2D32" modified="2013-07-24" version="1">MARSNIVDRKVQPLPERIDSLLSDVELLSRAGFFSQDVREEAGHEVRRYSKIYGVEDLDEIPFIRERSRLSGEETVPERFGQRLGHFATAFPLVPAVEPFGTGDSDAVKLDLVVGFINAVFGVNVSRSSAISDLQNLSDLIDAEMEAQERFDEMIADGFVPESISERHEAIEEHLEQVLENNGIDPVDPVVRDVISALGGSSELYGKVAESSGSSAPEEWDPSDAVSEQEILEIVEANRLVEKQHLREQLKCDLDELPGTTFSDLPATEVIIHADADVKTVEELAESVTEGYPGVNRRAEVLPAVGVHGKYLSGEHHSTLGTRDRPAVFQLDSSPADVRDWTLQLTQYGSALNHLLPRSTAGALRPLSVVPDDVISTALDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVC4</accession>
    <name>R4VVC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446074.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06155"/>
    <dbReference type="EnsemblBacteria" id="AGN01180">
        <property type="protein sequence ID" value="AGN01180"/>
        <property type="gene ID" value="L593_06155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180847"/>
    <dbReference type="KEGG" id="sali:L593_06155"/>
    <dbReference type="eggNOG" id="arCOG04696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129115_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043833">
        <property type="entry name" value="DUF5810"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19126">
        <property type="entry name" value="DUF5810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="161" mass="16944" checksum="70A59091DC358557" modified="2013-07-24" version="1">MAYACPVCETLAPDGEHLAHHLAIVAMTRGGDHERWLDDHAAGWREEGPEALAATATEYAETVEHELADESAGEHPDVGHDHGQTGGAGHADRVSQIGGAEPPAADNEETAAVLAEAREITQRMLGEDEASGSEKPNGETSGNEENDDERGEGPAETDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVG4</accession>
    <name>R4VVG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_01390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01390"/>
    <dbReference type="EnsemblBacteria" id="AGN00231">
        <property type="protein sequence ID" value="AGN00231"/>
        <property type="gene ID" value="L593_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.283"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_0_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="42764" checksum="FAC4DA802C1729CB" modified="2013-07-24" version="1">MTSVEARILVSLSIAFVALAGAYLVRRLRQRLSDRIAPIAVDLIGSVLSIAIIVGAVVAVADLWGETETLTSQFGLLELERRAPQIAVTVAVLVGVQVFTSVARRLLNDVTQESDAMSEHEREISYRLTQLLFWSVGIVFVLGVWEVNLGGLLIGAGFLGIVVGFAARETLGSLLAGFVLMFSRPFEVGDWIGVGEGAEEAEGIVTDITLMNTRIQAFDGEFVMVPNDVIGNRMVKNRSRKGRLRMEVEVGVDYEADVEHARDVATDAVSDIDMIMSVPRAETVVKEFDDSSITLGVRGWIEHPSSRRRWRARTRMIRAVKDRFAAEGVKIPFPQRELTGREEQGGFRVLGDAQAQSANADAPAAAPDRDNAPADGGVESADGGPASEEDGDDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVK4</accession>
    <name>R4VVK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445175.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00281">
        <property type="protein sequence ID" value="AGN00281"/>
        <property type="gene ID" value="L593_01640"/>
    </dbReference>
    <dbReference type="GeneID" id="16179897"/>
    <dbReference type="KEGG" id="sali:L593_01640"/>
    <dbReference type="HOGENOM" id="CLU_2476163_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="87" mass="9667" checksum="E7ED7AB7D5A21A5F" modified="2013-07-24" version="1">MTDLGGLLVGTLGMVGTVASGWYVIRGPFFGYPVPPAEYLLAACGVFILATYLFAWGLDRNYRSYKTERPNIDEEQNQTLDMPFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVT9</accession>
    <name>R4VVT9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446214.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06865"/>
    <dbReference type="EnsemblBacteria" id="AGN01320">
        <property type="protein sequence ID" value="AGN01320"/>
        <property type="gene ID" value="L593_06865"/>
    </dbReference>
    <dbReference type="GeneID" id="16181956"/>
    <dbReference type="KEGG" id="sali:L593_06865"/>
    <dbReference type="eggNOG" id="arCOG06897">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034084_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="117"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="41873" checksum="356718C3B47DCFFC" modified="2013-07-24" version="1">MPDVLVLDCHTTHSLAAIRALGRRGLTTTVASHRAWNPGRLSRHAGTFLRLPDPAVAQAAYLDAVEAELQARTYDVVVPVTESTVDLVVRNRDRVEPHAALPFPPYETLEVGLDKGQTIEAARALDVAHPRTMTATEVDLDAVGDELGFPVVVKPHYGSGREGVATAASPTELEPLYERTVAAHGPTLVQEYVPDGGERGVYTIYDREGTLAGVTVQERLRSRHPDGGASTLRETVVDPDLIRRADRLLAGLGWFGVAMVEFRIDPRDGAAKLLELNPRFWGSLPLSIAAGVDFPGLLYRLGIGEPLDRDLSYTAGVRARCLFADLLQVFEREDVLRALCKYVVPSRTRTHHDVVRLSDPLPTVGKLALLGADLRAAVTERVGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVW5</accession>
    <name>R4VVW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_07015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446244.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07015"/>
    <dbReference type="EnsemblBacteria" id="AGN01350">
        <property type="protein sequence ID" value="AGN01350"/>
        <property type="gene ID" value="L593_07015"/>
    </dbReference>
    <dbReference type="GeneID" id="16181965"/>
    <dbReference type="KEGG" id="sali:L593_07015"/>
    <dbReference type="eggNOG" id="arCOG00562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454662_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="88"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="600" mass="64107" checksum="15E2AFC74AC7F598" modified="2013-07-24" version="1">MSTSLDRFTALSRRLPAGLTAAHALFAAVIAVWAALYVYGLGDLSLRVWDESRYATPARIMAEGGSWLDPMIRVPTHEADLGESLRLNKPPLGYWLQAIAMSIFGVSEFAARLPTSLATLGCAALVYHVATVTYDRRAGFAGALGFLVFPGMLLGSHGGAAAVVDTPLALFGSLFVWWTWRGRDDPRLLLPAGIAAGLAVMVKGLAAGVFVIVLLPVGVLYLRDYLNRWTVAAVASTVTVALPWHLYAYLEHGDLFVEEYFLTSVGQRVSGQATEPPAEPLLPFLNYPWFKLAAGTLLPPYQYAIPVFGTGVVLALAFAWWRLRADGLRLRPGSGGRTGALSQFLPAAPVQDTTLLLLLWWTLAVPLTFMLGGGNHAWYLLPMYLPGAVLLGHLVAGIADGSFGAAFDDAKAGTRFGRSAPTDAGDATPETAGDTGPETAGDGGRRGRLARLRDAIPSTQRARRAVTERWGEAAGAAVYPATCVLLVVLLLGTYGAPLHEPYNDEQRALGTTIAEEVPEGETVHVWLGEDGDTESIMSVSWYADRPLERADRAAIEGDPSVRYAIVPLGNASEIDRSHRVLAESPLNGIAFVAFEGESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVY3</accession>
    <name>R4VVY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase or acyltransferase of alpha/beta superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446264.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07115"/>
    <dbReference type="EnsemblBacteria" id="AGN01370">
        <property type="protein sequence ID" value="AGN01370"/>
        <property type="gene ID" value="L593_07115"/>
    </dbReference>
    <dbReference type="GeneID" id="16182267"/>
    <dbReference type="KEGG" id="sali:L593_07115"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_43_0_2"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="28969" checksum="423A7AF004BFDA61" modified="2013-07-24" version="1">MQTTKFTDGTTISFETHGAQERDTQRAAPACDRGPEPLILVHGSTGSRESWLPHLREAGPLVAMDRRGRGESGDAPDSYALEREVGDVEAVLETTGAMRLFGHSFGGLCALNVATRDAVDLEKIVLFEPAILVGEHRAYDAADRMADLLDDGDREGAMRLAFREMTGIEDVEALPHWPEVIELAEVTQREFEAVEFYELPGPLDVDPVVLLLTGEHSPDFLTDAVREVHDRLPESRLVEVEGVGHTGLEDPARTMSPVVDFLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVZ0</accession>
    <name>R4VVZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme of phenylacetate metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445325.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02400"/>
    <dbReference type="EnsemblBacteria" id="AGN00431">
        <property type="protein sequence ID" value="AGN00431"/>
        <property type="gene ID" value="L593_02400"/>
    </dbReference>
    <dbReference type="GeneID" id="16182532"/>
    <dbReference type="KEGG" id="sali:L593_02400"/>
    <dbReference type="eggNOG" id="arCOG10158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204055_0_0_2"/>
    <dbReference type="OrthoDB" id="94268at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11731" checksum="D2C478D9CDB5BFD7" modified="2013-07-24" version="1">MIWEVFRQQAAGDYHTHCGNVHAPDREMALLFAEIQHGRRKPTNSLWVVPKPEIAEVDTDDAVFGGSTDKAYRFAQSYNVEPAAEEVADSEREQTEAERQRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW00</accession>
    <name>R4VW00_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446284.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07215"/>
    <dbReference type="EnsemblBacteria" id="AGN01390">
        <property type="protein sequence ID" value="AGN01390"/>
        <property type="gene ID" value="L593_07215"/>
    </dbReference>
    <dbReference type="GeneID" id="16182066"/>
    <dbReference type="KEGG" id="sali:L593_07215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1473"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695609_0_0_2"/>
    <dbReference type="OrthoDB" id="63002at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="38869" checksum="D5C72B225629E0E6" modified="2013-07-24" version="1">MVGIATVATVLVAGLASLFMAWAIGAGSSGSTPFAPAVGANAISVMRAGFVVGLLGLGGAVIQGANVSEAVGRELIVGDPLSAQAAALALTIAAALVAVGIFAGYPIATAFTVTGAVVGVGLAMGGDPAWPKYVEIATLWVLVPFVGGGIAYVTARFLRSEATSERLTLPVLAAVVGALIANVDVALLGENGASIAASAGVALADAAAVPSIAGHLLATAAFALAFAGTLYRELVIDPAQGQRRFLLALGGLVAFSAGGSQVGLAIGPLLPLLDPYDVNLFAVLAGGGLGLLVGSWTGAPRMIKAIAQDYSSLGPRRSIAALIPSFAIAQAAVLFGIPVSFNEIIVSSIVGAGYASGEGVSAEKVGYTVLAWVASLAIALGSGFGIYAALAALFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXD6</accession>
    <name>R4VXD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446799.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09800"/>
    <dbReference type="EnsemblBacteria" id="AGN01905">
        <property type="protein sequence ID" value="AGN01905"/>
        <property type="gene ID" value="L593_09800"/>
    </dbReference>
    <dbReference type="GeneID" id="16180263"/>
    <dbReference type="KEGG" id="sali:L593_09800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2017"/>
    <dbReference type="eggNOG" id="arCOG04568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177453_0_0_2"/>
    <dbReference type="OrthoDB" id="125792at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043931">
        <property type="entry name" value="DUF5779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19091">
        <property type="entry name" value="DUF5779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11477" checksum="01AAC53C9FAF2E79" modified="2013-07-24" version="1">MSDFDLDLRAVEEHVEEAEAEEEQDGSGGRVVLDVLDGSTDDEEWLELIQGGNVLVLNVEGDVNELAAGFAREVRDADGDLVHFRGFLIVAPPGVEVDRDRLQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI9</accession>
    <name>R4VXI9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="7" type="ORF">L593_10125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446864.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10125"/>
    <dbReference type="EnsemblBacteria" id="AGN01970">
        <property type="protein sequence ID" value="AGN01970"/>
        <property type="gene ID" value="L593_10125"/>
    </dbReference>
    <dbReference type="GeneID" id="16180261"/>
    <dbReference type="KEGG" id="sali:L593_10125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2087"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OrthoDB" id="57654at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="259" mass="28606" checksum="5DA2F2013B09D164" modified="2013-07-24" version="1">MQGQAQQQAYDRGITIFSPDGRLYQVEYAREAVKRGTASIGIRTEDGVVLAVDKRIRSPLMERTSVEKIHKADDHIGIASAGHVADARQLIDFARRQSQVNQLRYGEPIGVETLTKNVTDHIQQYTQVGGARPFGVALIVGGVEDGEPRLYETDPSGTPYEWKALAVGADRGELQEYLEEHYEEAEDISGGVELALEALASVNDGELRPEGIGMATVDVESENFIELTDDEIEEYLESNDLLAPEEPEEDVEDADEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXN5</accession>
    <name>R4VXN5_9EURY</name>
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        <submittedName>
            <fullName evidence="8">Acetate/CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_10375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446914.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10375"/>
    <dbReference type="EnsemblBacteria" id="AGN02020">
        <property type="protein sequence ID" value="AGN02020"/>
        <property type="gene ID" value="L593_10375"/>
    </dbReference>
    <dbReference type="GeneID" id="16179933"/>
    <dbReference type="KEGG" id="sali:L593_10375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2139"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OrthoDB" id="24323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="95"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="545"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="661" mass="74344" checksum="FEC0B2A6F8164788" modified="2013-07-24" version="1">MSDADTEAELEARLEEQESFEPPEWFVEQANVSDPDIYDEFEENWPECWERAADLISWEEEYDQVLDDSDEPFYEWFTGGELNASYNCIDRHVENGQKNRAAIQWEGELGEERTITYQELQREVEAFAAALREQGVEEDDVVTLYLPMLPQLPIAMLACARIGAPHSVVFAGFSAEALAERMNAAESEYLVTCDGYYRRGEALNHKEKADEGLQQVDHDVESVIVVDRLGDELTHFLGDNAHDYQELVDEHEGASVTPVSRDAEDMLFLMYTSGTTGTPKGVKHTTGGYLSYAAWTTQSVLDVKQEDTYWCAADIGWITGHSYIVYGPLALGTTTVMYEGTPDYPEKDRLWELVEKYGVDMFYTAPTAIRAFMKWGQQYPDSHDLSTLRLLGTVGEPINPRAWKWYYKHIGHEDVAVVDTWWQTETGGMMVTTLPGIGEMKPGSAGPPLPGIDARIVDNQGDEVEPGDAGYLTVNNPWPGMLRTLYKNDERFLEEYWREYSDEETDEWVYFPEDGASIDEDGYITVLGRVDDVINVSGHRLGTMEIESAVVDVEGVAEAAVVGGTHEVKGEAVYAFVITEDGQSEDDALRERVVERVEDAIGPIARPERIVFTPDLPKTRSGKIMRRLLEEIADGEELGDTSTLRNPDIVQDIKDEVDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXS2</accession>
    <name>R4VXS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445955.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01061">
        <property type="protein sequence ID" value="AGN01061"/>
        <property type="gene ID" value="L593_05560"/>
    </dbReference>
    <dbReference type="GeneID" id="16181453"/>
    <dbReference type="KEGG" id="sali:L593_05560"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529196_0_0_2"/>
    <dbReference type="OrthoDB" id="110999at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="17332" checksum="D36975096DB3798D" modified="2013-07-24" version="1">MLTQFTLVVLVASRTVAQSATDVGTNLLGSAVGAFLGTLIVGGIMILVFPDYTERTVRTLRRDPGPSLLYGLLTLVALIVLTVLLVLTIVGILVVIPLAFLAYILWAVGAAIAFITIGDRLVGHEGGWTAALVVGSAINGVLVLTGIGGFVSFLIGAAGFGAVIHGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYL1</accession>
    <name>R4VYL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446215.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06870"/>
    <dbReference type="EnsemblBacteria" id="AGN01321">
        <property type="protein sequence ID" value="AGN01321"/>
        <property type="gene ID" value="L593_06870"/>
    </dbReference>
    <dbReference type="GeneID" id="16181920"/>
    <dbReference type="KEGG" id="sali:L593_06870"/>
    <dbReference type="eggNOG" id="arCOG04679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108336_0_0_2"/>
    <dbReference type="OrthoDB" id="123795at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="20617" checksum="C06ED80E377E5E39" modified="2013-07-24" version="1">MAPVTSGASGGSEGDERRRLVSRRSQLVLVAAGVIAMGLLPIVLAYTQLGYAGMAATEPSATTATADAHRAIERAAFDASEPSQGVRPWAARSGVADEVASRFDDRVASIETGRIERGIHHAIERNTSAASAWASANCPGGSSRQFGPCEAREGIVLQERGGDTQVLAIAVDLRTLTEDATYTGTYLLDAETGTGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYN9</accession>
    <name>R4VYN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446245.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07020"/>
    <dbReference type="EnsemblBacteria" id="AGN01351">
        <property type="protein sequence ID" value="AGN01351"/>
        <property type="gene ID" value="L593_07020"/>
    </dbReference>
    <dbReference type="GeneID" id="16179852"/>
    <dbReference type="KEGG" id="sali:L593_07020"/>
    <dbReference type="eggNOG" id="ENOG502N64W">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324068_0_0_2"/>
    <dbReference type="OrthoDB" id="139881at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="24343" checksum="33DAB101CDCCD606" modified="2013-07-24" version="1">MTITESDQETYQSTVSDFQPQITEDACLPTAIKNILDDLAERRDISGLSMSQSDVNDLCEYREGFYSQEEIIPEQLTHEVSEYGYEAVEATGHQMDFEYLQSIIDREDASLPIVELDPEYFLDVEGYRVQEAENMPSHTVIVFQINDEQVLYYDPYEKFFESSSRIEEAPCTWPKTEFFELWSGRFEERWTLWLDRSEQQPLAQFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYT2</accession>
    <name>R4VYT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PGF-CTERM archaeal protein-sorting signal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446295.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01401">
        <property type="protein sequence ID" value="AGN01401"/>
        <property type="gene ID" value="L593_07270"/>
    </dbReference>
    <dbReference type="GeneID" id="16182081"/>
    <dbReference type="KEGG" id="sali:L593_07270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1484"/>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573194_0_0_2"/>
    <dbReference type="OrthoDB" id="17522at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="48149" checksum="A3D52AF3CF4E2955" modified="2013-07-24" version="1">MAGRSGPGRAIARPAAAGTESVGDAVPRVVERVVYRDGDVDGAVDVAIVYEIPDAVSKLAFWIERPTVSVVATDGFDRSDVGGYTWQGSVDGPAFEWDGSGDRATVICRQPLTADDPSTYGAGTDDWALCLRPRTHTRWRYRGTEPRIDRRAAVRGVGIAGEQFVCLGEHAIAKRRVDAETVRLVVPAAATPSTAPDRILDSLAAASEHLDVGGRSDLVTVFVAPTDGACWAHRGLSLGPDARVNDDAALAAPTNIWVHEYVHTRQDRTATTAATEWLLEATAEYYALTQAFERGAIDFPTYRQVLERGVGEDSPEVVLADPSTWADDAQYRTGALVVAALDRRIRAASGGETTFQAVLRTWNAAAPAPFDATAFADAVERAGGPAARAAAIAYTETPTTPRPWSASTHAATFDVSPADCEAAGSPLDADQSGWTTADRVGDVAIDRAAPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYW5</accession>
    <name>R4VYW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12580"/>
    <dbReference type="EnsemblBacteria" id="AGN02455">
        <property type="protein sequence ID" value="AGN02455"/>
        <property type="gene ID" value="L593_12580"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2582"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_8_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22134" checksum="2985546C08CA60BC" modified="2013-07-24" version="1">MVESAREYETGWFDGGYDLVEQPDGSTKRYYWAELAPAVVVVGIVDGDHVERDPTDDAGADEEERNEPHVVFVEQYRPTIRETQFELVAGIVDEHDGGPAETVEAAAYEAAAKRELREETGYVAEDVAVLESYAVATGVLRHRRGIVVATGLTPGEPDRDDNEFLSVEPVPVSDALTVAREPPTNDATLEGLLLADADGYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYZ3</accession>
    <name>R4VYZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447379.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12730"/>
    <dbReference type="EnsemblBacteria" id="AGN02485">
        <property type="protein sequence ID" value="AGN02485"/>
        <property type="gene ID" value="L593_12730"/>
    </dbReference>
    <dbReference type="GeneID" id="16181232"/>
    <dbReference type="KEGG" id="sali:L593_12730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2612"/>
    <dbReference type="eggNOG" id="arCOG02228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_6_1_2"/>
    <dbReference type="OrthoDB" id="88809at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="15472" checksum="1201CB7ABA5C02CB" modified="2013-07-24" version="1">MLRSFLRNLLSGPIAPQLRKFVAVGVVAAGLQLVLLWLFVDAGGLHYLLGAVVAIECTIVFQYVLNNRWTFRSDRNTGTREFLVGLAQTNVVRGTAIPIQIGVLYALVQYQGVPYLLANAAGILVSGVYRYVFDARWTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ20</accession>
    <name>R4VZ20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446390.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07755"/>
    <dbReference type="EnsemblBacteria" id="AGN01496">
        <property type="protein sequence ID" value="AGN01496"/>
        <property type="gene ID" value="L593_07755"/>
    </dbReference>
    <dbReference type="GeneID" id="16182212"/>
    <dbReference type="KEGG" id="sali:L593_07755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1589"/>
    <dbReference type="eggNOG" id="arCOG00315">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OrthoDB" id="81913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="18882" checksum="A858F13E77CE41AF" modified="2013-07-24" version="1">MVDFEVVDLPETDHVAVGEQAPDFERPLVNDEFWEDVALSDLTAEGPVLLVFHPMDGAFPATYVWSEIRDREWTSAFDAQIVGCSISSPYEHKDLIADSGIDASLFSDPAADVAETYGVENDLDGMAGITEHRPAVYLLDEERVVQYAWVAEQWPDFPPYDEVEDALGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ89</accession>
    <name>R4VZ89_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein L593_08130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08130"/>
    <dbReference type="EnsemblBacteria" id="AGN01571">
        <property type="protein sequence ID" value="AGN01571"/>
        <property type="gene ID" value="L593_08130"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1666"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873208_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="38993" checksum="3A1EA2B27FB7CDA8" modified="2013-07-24" version="1">MTVIATVGLPGSGKGEAATQAEDLGIPVVTMGDVIRQACRDRGLDPAEHHGAVAQALREENGPGAIAEASLPQIEAHLQDEDVVLVDGVRSGVEVDQFEEAFGEDFVLVSIEAPFEVRKDRLTERGRDNLDGESLEDRDERELGFGMGEAMERADVRIENTESLEAFQERIRDVIETEIDGDLGAAAGSGDGTTVIDEGGTETDDDATTDGGRSPTDDGTSPTDGAVYKVDVEVTAPVYPTEVTDRVADAIHNLFPEAEIEHREGELAGTAHSMERFSELLHEREILDTARDQFFANRRGDTVSFDLKKQAAFEGLVNFAVGQPDEVGELHVRVRVDEPSVEAYVDHVAPRTEDGRPVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZF8</accession>
    <name>R4VZF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, type IV secretory pathway VirB11 component like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447549.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13580"/>
    <dbReference type="EnsemblBacteria" id="AGN02655">
        <property type="protein sequence ID" value="AGN02655"/>
        <property type="gene ID" value="L593_13580"/>
    </dbReference>
    <dbReference type="GeneID" id="16182012"/>
    <dbReference type="KEGG" id="sali:L593_13580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2780"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_9_1_2"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="433"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1380" mass="149094" checksum="5BC93E06395620FB" modified="2013-07-24" version="1">MAIDEADSAESGQIGESDDSESTSETGAGDASPDPVAVGRYTWADFLDDHGLEDQVSDLYPRGRPQAGAAADVGLSSGDDVQRRTPSGSDWDDVSFDPADYLGFHPDDLEQRITEEAGASAKWLDAEFEEFADPDSTPVVKDVWMWEHFKRLYYYDTDGSRPRDSDGEVEPFDSTDYLSFDAEETEGVLAQAGSIARELDEVVERRTVDVEDDVDEDEFFSDEHGNTTVTNRYDLEKAVPMEKKTHFVEEDRYWVNKPYAFVILFHSRKENEKKYYAVEPNLNEIEEDLREFLIGKLRTAIKYADEDVAAGADSTEAERRAVIERETKRLLDRYDLFDGSVETATGSGSDGGSGGFLDEIKAMFGDDDGSSPEADEDESVPDQLAGIEARPEPAVLADDAETLTEYQIQKLLYLLKRDFIGYERIDPIKHDINVEDISCDGYNSPVFVYHTDYEQIISNIYHGQAELDDFVVKLAQRSGKGISKRRPQVDATLPDGSRAQLTLGREVSDHGTNYTIRQFKDVPFTPIDLINWNTFSLEEMAFLWLCIENHKSLIFAGGTASGKTTSLNAVSLFIPSNTKIVSIEDTREVELPQRNWIASVTRPSFSDDAQGDVDEFDLLEAALRQRPDYIVMGEIRGEEGRTLFQVMSTGHTTYTTFHADSVGEVLKRFTTEPINVSKTMFTALDLVSIQTQTRVHGHKVRRNKTLTEVNHYDAENDEINVQDVYQWQAETDEFLKLGDSNTLEEIKFDRGWNDERLQQELFKREIILAYLIKNGLNQYREVAATIQAFINDPDTILTLIANGQLEDSLEDLREMESVLIDVDPAKEELVPRPDPDDEGYNLAMSIVEEADESLFDEYRGKSVEGLESALEGVSEPEPGVETDVDEEEISFEGEVADGFESEFSFGGDSAPFDGDDEAEAGADAAEPEAAAAAGDDAGDSSDPFSGGPDWLGGDGEETTEDIWADAREALEGGDSPDDEQSGESDAADATPAADSDPELEDQDGETVGPSALADSSEAADGATDAGDGAEPAALPDDEASKPESGDDDEAPQPPELDAGEAVEPGDEDETDAVSGDRPDVEHDDETTMEAVDGDGDDADSDSEPAAEADATPDEDSDSSKPSDAAATAAAETTATSSESNAAESTESETPAESNRSQSPDESNRSDSPATSTQPSEASSAVSSSVDDSDAPGDDAEADNTETSTRASSDASESQAKAEREPDTETDATDSAGDAASQASDESEADDPDGDTDADAFETGGESDDEPAVAGVDEEPDDPFDRVLDDSDSEPDEEADAPGPFGSAAEDDTGPFSDDDGDDPFGGGSGGPFADPPDDESEADDADGSDTDGESSDGGPFGSDPSSDQGPFGSAEDDADEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZT5</accession>
    <name>R4VZT5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446620.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08905"/>
    <dbReference type="EnsemblBacteria" id="AGN01726">
        <property type="protein sequence ID" value="AGN01726"/>
        <property type="gene ID" value="L593_08905"/>
    </dbReference>
    <dbReference type="GeneID" id="16182572"/>
    <dbReference type="KEGG" id="sali:L593_08905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1827"/>
    <dbReference type="eggNOG" id="arCOG04634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_2"/>
    <dbReference type="OrthoDB" id="7579at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="721" mass="76582" checksum="40A6A59CB934B88C" modified="2013-07-24" version="1">MDHQTDRVQELVDQLTREEKLSLVHGHVDPTRSATGYLPGVERLDVPEFRLVDGPLGVRVPGESSTAFPAPLAVAATFDPDLARQKGAAIGRETRALGQDSLLAPGLNLIRMPHCGRNFEYYSEDPVVTSAFAAASVEGVQSQDVIATPKHYVANNQETDRAVVSADVSERALRELYLPGFEAAVESGAGSVMTSYNRVNGTHMSENERLVTDVLKEEFGFDGYTVSDWYGTESTVAAANAGLDLEMPGIPMEAMMGPAMEDDGADAEDEAAEGDEASPDAGDAPEEIDLGEFEDGMPDPENHGQFAEPLGEAIDAGEVPESRLDDMVARVLGQMAACGALDGEQTDGAIDTDEHRELASEIASRGQVLLENDGVLPFADDVDVALVGPNLDEPTLGGGGSSETTPIEATTTVEGVEARASEGGGDVTVARGVAPIEDLSFFDLGEDDEEAEFDGSIDDAVAAAEDADVALVVVRDQATEALDRPDLRLPGDQDDLVEAVAAANENTVVAVRSSGPVELPWREDVAAILTSWYPGQADGESLATVCWGDVDASGRLPVTFAPESEYPARAPEQYPGVDGHASYDEGVFVGYRHFDAGRGTATYPFGHGHSYAAFEYRDATAVDESTVEVTVANVAERDGREVVQAYVRPPEADVERPERELGGFTAVDVPAGEERTVTIDLDDLAFAHYDEVGGWATPAGEYAVEIGRSAQDLRLSTTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W050</accession>
    <name>R4W050_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446750.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09555"/>
    <dbReference type="EnsemblBacteria" id="AGN01856">
        <property type="protein sequence ID" value="AGN01856"/>
        <property type="gene ID" value="L593_09555"/>
    </dbReference>
    <dbReference type="GeneID" id="16182659"/>
    <dbReference type="KEGG" id="sali:L593_09555"/>
    <dbReference type="eggNOG" id="arCOG07263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054760_1_0_2"/>
    <dbReference type="OrthoDB" id="71086at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="34242" checksum="AF0E61F2B8CF0CDF" modified="2013-07-24" version="1">MPELHTTLGALDREAIDLILPHEHVFTDLGPMEERAHETADLEEVVEVVGPEIERAKEAGVTGIVEPTPRGVGRRVDAVEAVSEATDFPIAVATGIYQEPRIPEWAREAGEDELTEWMIEELTEGVEEAETQAAFIKVSTDDDDPEALSDDEETILRAAARAGAETGAAIGSHTLYADMVETQLDVIEDAGYTADRFVWIHAQAEDDLDRHVEIAERGAWIEYDWIGGDDQPDAAYVERIERLLAADLGDQLLLSQDRGWYDPSEPRGGEVKPYTYLTDEFLPALREAGIDEATIRQLTEDNPFDAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0G3</accession>
    <name>R4W0G3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10280"/>
    <dbReference type="EnsemblBacteria" id="AGN02001">
        <property type="protein sequence ID" value="AGN02001"/>
        <property type="gene ID" value="L593_10280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2119"/>
    <dbReference type="eggNOG" id="arCOG01846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="39846" checksum="84522133BACD8281" modified="2013-07-24" version="1">MNEEAVRERLATVEDPDLGDDIVSLGLVNDVEVGGDTAHISLALGAPYSPTETAMAAKVREALADTDLTVELDADIDLDDGGSQEGILPGVENVIAVASGKGGVGKSTVAVNLAAGLAEMGAQVGLFDADVYGPNVPRMVEADEPPRATHDETLIPPEQYGVKLMSMAYLVGEDDPVIWRGPMVHKVLTQLWEDVEWGYLDYMVVDLPPGTGDTQLTLLQSVPVTGSVIVTTPQDVALDDARKGLEMFGKHETPVLGIAENMSTFVCPDCGGEHDIFDAGGGQQFADVHEMPFLGSVPLDPAVREGGDDGRPIVLDEEGEAAEAFQEITRKVANNVGIVRRRDVSNRAKAEAAAEADAAEAEADGHAPESPEIGGDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0U6</accession>
    <name>R4W0U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8p</name>
        <name evidence="4" type="synonym">rps8</name>
        <name evidence="6" type="ORF">L593_11180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447075.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11180"/>
    <dbReference type="EnsemblBacteria" id="AGN02181">
        <property type="protein sequence ID" value="AGN02181"/>
        <property type="gene ID" value="L593_11180"/>
    </dbReference>
    <dbReference type="GeneID" id="16180058"/>
    <dbReference type="KEGG" id="sali:L593_11180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2306"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OrthoDB" id="91154at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="14061" checksum="6A5E6216352C3FA8" modified="2013-07-24" version="1">MTADDPLANALSGLDNAESVGHLTHEVSPASEEVGSVLEVLYDRGYIEGFEHVDDGKAGRFEVELNGAINDCGPVKPRYSAGADEFEKWEKRFLPARDYGALVVTTSHGIMSHYEAREAGVGGQVIAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0V8</accession>
    <name>R4W0V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447085.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11230"/>
    <dbReference type="EnsemblBacteria" id="AGN02191">
        <property type="protein sequence ID" value="AGN02191"/>
        <property type="gene ID" value="L593_11230"/>
    </dbReference>
    <dbReference type="GeneID" id="16180750"/>
    <dbReference type="KEGG" id="sali:L593_11230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2316"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_2_2"/>
    <dbReference type="OrthoDB" id="41707at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03418">
        <property type="entry name" value="GRX_GRXb_1_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011900">
        <property type="entry name" value="GRX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02181">
        <property type="entry name" value="GRX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="101"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="447" mass="48293" checksum="FDB1641E7A4A3A6D" modified="2013-07-24" version="1">MTQPHVEVYTKDNCSYCEKAKDLLDSKGIEYEEYNVSGDDELFEEMVERADGRKTAPEIFVDDELIGGCDDLYELEEAGDLDPKLGLDPAATDGGIEEHRRMIIAGSGIAGMTAAIYAGRSNNDPLVIEGDEPGGQLTLTTDVANYPGFPEGIGGPELINRMREQAQQFGAEFENGIIESVDAECRPFHVKMTSGDLYTADAVIAASGASARTLGVPGEDELMGYGLSTCATCDGAFFRDEDMLVVGGGDAAMEEAHFLTKFADTVYIAHRRDEFRAEDHWIDRIMEKQEEGDVEIMWNTELAEIHGTPEDGVDHVTLLRHPGGHPKDKRDDPEFAEEVEEFEHDVGAVFYAIGHTPNTDYLEGTDVEMDADGYLKVQGGFGGGQTQTAVEGIFGAGDVVDYHYQQAITAGGMGSKAAIDADEWLENEADLAAAEGGAEPAAAESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Y5</accession>
    <name>R4W0Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447090.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02196">
        <property type="protein sequence ID" value="AGN02196"/>
        <property type="gene ID" value="L593_11255"/>
    </dbReference>
    <dbReference type="GeneID" id="16182546"/>
    <dbReference type="KEGG" id="sali:L593_11255"/>
    <dbReference type="eggNOG" id="arCOG08021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187344_1_0_2"/>
    <dbReference type="OrthoDB" id="125915at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9335" checksum="60517760FCC989EE" modified="2013-07-24" version="1">MANPVPPTVSCDELAVPQQLESPRSKLLYLALAVTDGAKTSELRSALQMSSLSLYPVVADLRDAGLVERADDGSLRLSEIERPPVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1W2</accession>
    <name>R4W1W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PrgY-like protein, pheromone shutdown like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447545.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13560"/>
    <dbReference type="EnsemblBacteria" id="AGN02651">
        <property type="protein sequence ID" value="AGN02651"/>
        <property type="gene ID" value="L593_13560"/>
    </dbReference>
    <dbReference type="GeneID" id="16181364"/>
    <dbReference type="KEGG" id="sali:L593_13560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2776"/>
    <dbReference type="eggNOG" id="arCOG02142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032780_1_0_2"/>
    <dbReference type="OrthoDB" id="52124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="580" mass="60089" checksum="02D288BE3BA9E9F7" modified="2013-07-24" version="1">MKEAAGDAVSDGPGEVTVVGTAHVSEESAERVRDEVEEHDPDVVAVELDEARYRQMMQDEAPDDLEPADLLSGNTVFQFLAYWMLSYVQNRLGDRFDIEPGADMRAGIDVAEEHGLGLALVDRDIQETVQRFWARLSIREKFGLVGGLAIGAADGPMIGLSMGVAFGVIFGLIGGLALAPALGLGGAFTLGLGGTLAAGIVGGVVLGGLVGLVVGVGVVPPFSLPGVGYLGPIERSLGGLLGGVAIGGALAGTGASLPIVGTPDFVPIGGTVLRGLVGALSGGAVSGILGMGLGAVFGPSGSAEDQLEEFDIESLTDADVVTAMMEEFRQFSPGGAEALIDERDAYIAHQLVGLRGQGYDVVAIVGAGHREGIESYLAAPETLPTMESITGTEDSGRFSWGKAFGYLVLVGFVAFFGLLALGGAQNVFLLKLFGAWFLFNGTFAFVCARVAGARLDSAAVGGGVAWLTSINPLLAPGWFAGYVELRHRPVNVADIGRLNELLDDNERPLGDVLGDMLDVPLFRLIAVVAMTNVGSFLASILFPFVVLPFFFEGVGGVGEVGELLLQGVENGLDLLIDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1Y8</accession>
    <name>R4W1Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_13710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447575.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13710"/>
    <dbReference type="EnsemblBacteria" id="AGN02681">
        <property type="protein sequence ID" value="AGN02681"/>
        <property type="gene ID" value="L593_13710"/>
    </dbReference>
    <dbReference type="GeneID" id="16180798"/>
    <dbReference type="KEGG" id="sali:L593_13710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2804"/>
    <dbReference type="eggNOG" id="arCOG01250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045500_0_0_2"/>
    <dbReference type="OrthoDB" id="29412at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="39139" checksum="A4428C7467567240" modified="2013-07-24" version="1">MNEDDLDPIPPAEAVPLYLDHREPEVTEKTLHNHEYRLELFCEFCGKFGIETLDELTPRDIHQFRSWRRREGNVATVTLRGDLATLRVFLEFCADLNFVPDGMRERVKLPSLDRADEARDVKLDVDRAEDILQYLERYEYASRDHVVLAILWHTGIRMGALRALDVDDFDQEAQCLDLRHRPESGTPLKNGDAAERSIAVGDYYCGVLQDFIRNNRYKITDDHGRRPLISSNQGRLTATPIRDTVYGWSRPCQVGKDCPHDRDIEECEAIPPKAASKCPSSRSPHSIRRGSITHHLRTGTPERVVSDRMNVSADVLDQHYDRRTDREKMELRRDHLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2B1</accession>
    <name>R4W2B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14310"/>
    <dbReference type="EnsemblBacteria" id="AGN02801">
        <property type="protein sequence ID" value="AGN02801"/>
        <property type="gene ID" value="L593_14310"/>
    </dbReference>
    <dbReference type="GeneID" id="16181182"/>
    <dbReference type="KEGG" id="sali:L593_14310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2929"/>
    <dbReference type="eggNOG" id="arCOG01480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021126_0_1_2"/>
    <dbReference type="OrthoDB" id="68852at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="325" mass="35104" checksum="3B3C6B35BAECEDB2" modified="2013-07-24" version="1">MASSVSVVLAALVANGAIAALKFGGFLLTGSPSMLAETYHSISDTGNQVFLLVGIFYGRKEADEQHPFGYGKAEFFYSFLVSVFLFGIAGWESAKHGYEAIRHGETSVVEGTQTIPLIDLTLQGVYVNYGILLAAMVFEGYALMKARAGMKNEMERHGYDGYVEAFRKTSQTTILTALTEDTIALSGLALALLGIFLSRFTGNPVYDAATALLIGLMLMGFAIALAWENKRLLIGESLQPDDEDELRKIVRETDGIADITDFRTVYFGPGNVIVTGDVAFERGLATAEIDDRMEAIRTAIEEANPAVSRTYLEVETTPDADGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2C4</accession>
    <name>R4W2C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447715.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14410"/>
    <dbReference type="EnsemblBacteria" id="AGN02821">
        <property type="protein sequence ID" value="AGN02821"/>
        <property type="gene ID" value="L593_14410"/>
    </dbReference>
    <dbReference type="GeneID" id="16181214"/>
    <dbReference type="KEGG" id="sali:L593_14410"/>
    <dbReference type="eggNOG" id="arCOG07539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206273_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="59" mass="6637" checksum="C885E0EAC043E804" modified="2013-07-24" version="1">MALNKLRQLDSDTIGVTIPKDDLRLDGLLDDAGDLEGEHHVHIDRQDSGEWELTLVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2G4</accession>
    <name>R4W2G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447770.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14710"/>
    <dbReference type="EnsemblBacteria" id="AGN02876">
        <property type="protein sequence ID" value="AGN02876"/>
        <property type="gene ID" value="L593_14710"/>
    </dbReference>
    <dbReference type="GeneID" id="16181425"/>
    <dbReference type="KEGG" id="sali:L593_14710"/>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_0_2"/>
    <dbReference type="OrthoDB" id="88905at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16997" checksum="FC911CC9D59C4573" modified="2013-07-24" version="1">MSTTAEENKRIVRRIRDEVEEQGDLESVDEIFAADVVVHTPMGEFRGREAIKEMYQSDNEAFSDSTETIHDVVADDDTVAIRMTERGTHDGEFLGMEPTGREYEIQTTAFLHLDDGKVTEWWIQPDTLGFFRQLGVDPEEISEAVPAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2U3</accession>
    <name>R4W2U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type antimicrobial peptide transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_00985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="411" mass="44007" checksum="7EBCAF58BF2E0776" modified="2013-07-24" version="1">MKIGESFRISWRAITGHKLRSTLTTIGIVIGIGSIIAFMVLGGAFEEDAIGGFDTEEQTLVLVQTQGNVENGFGFQTFQDPIYTASDVEQIEQIDGVEFVDPDGTIPASQLRYGDESTVSFTVRIADPRSFSKNVSGSFVEGEPFAGPGETVIDTRLAESLGGNVSVGDEIQVSFSDGTRERFTVSGIFNAENQGPGIGASLWVAEDPYYNVTVETPSGERERAYTSLNIWVESFDDINDVTEQTDAYFHSGDSDAEQLVDDDKRIAVQTLDQLLGQVAEIFDQVTIFIAGIAGIALIVGAIGIANIMIVSVTERTREIGIMKAVGANNRDIVQLFLIESLILGIIGSIGGVGLGLGGGFLLVSFAAFPMVYPTDWIVIAVVVGIGVGVVSGLYPAWRAARVDPIEALRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W338</accession>
    <name>R4W338_9EURY</name>
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            <fullName evidence="3">Glucose/sorbosone dehydrogenase</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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            <end position="366"/>
        </location>
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            <begin position="23"/>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="461" mass="47766" checksum="0AC93B1164F412B2" modified="2013-07-24" version="1">MDESVTRRRALFLGGAAVGIAGCIGTDDGTESNDDGDGTGDGAPDGAGGGQDGSDDGTDAEVPLQNVPDSIALDTLVDGLQAPVGIEFSPDSERAYVLEQGGRILALDGSGSLLDSPVLDLREPIVAGGERGLLGLALHPEFASNRQAFVRYSAPSREGTPDGYDHTFVLASFEATEDGTSFRRESEQTILEIPEPQSNHNAGDLAFGPDGYLYVPVGDGGAGDDQGAGHVDDWYGEVAGGNGQDVTENLLGSLLRLDIDGGDPYAIPDDNPLVGEAGRDEHYAWGFRNPWRISFDAGGDGTDLYVADVGQSSYEEVNLVEAGGNYGWNVREGAHCFQTESCPSRTPDDVRGGEPLLDPVVEYPHSGGEVTGVSVIGGHVYRGAAIDGLGGVYVFGDFAPRGKLFASAPGEGGSTWPIRTIAIDGASVESLYAFGQDGEGECYALGSGANGGTVWRLGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W378</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
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            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="27420" checksum="4B16C88E4DE158A0" modified="2013-07-24" version="1">MAVLHFVQGAAMLALADYVDWPVTYTRYEFDEATETLAPIAADWAEVPLPLLVAGFLFLSALAHATIATVRYEQYVHYLERGMNPYRWYEYSVSASVMIVVIGMLSGIWDLGALLALFGLTAVMNLCGLLMEQRNEDRERIDWTPYWVGVLAGIVPWIVIAITFGGTVLAAGGDFPEFVIYIYVSIFVFFNLFAVNMVLQYRETWRWKEYLFGERMYVLLSLVAKSLLAWQVYFGTINSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3E2</accession>
    <name>R4W3E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02630</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445371.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02630"/>
    <dbReference type="EnsemblBacteria" id="AGN00477">
        <property type="protein sequence ID" value="AGN00477"/>
        <property type="gene ID" value="L593_02630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180453"/>
    <dbReference type="KEGG" id="sali:L593_02630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.533"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0670">Pyruvate</keyword>
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        <location>
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        </location>
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        <location>
            <begin position="432"/>
            <end position="473"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="585" mass="63847" checksum="FFF8569ED801122D" modified="2013-07-24" version="1">MAEDLNWAIGGEAGDGIDSTGKIFAQAQSRAGRHVFTSKDFASRIRGGYTAYKIRSSTERVQSVVDRLDVLVALTQRTIDENLDELHDRSVVVYDGERSWEAEIPGEIDAVDVPLKSLAEEAGGAIMRNVVALGAVCAIVDFPVEKLDEALEKRFGGKGEKIVENNKQAARLGAEYVEENYDGFDYSLETTDNDYVLLNGDEAIGMGAIAAGCRFYAGYPITPATDVMEYLTGRIDRFGGHVVQAEDELSAINMALGAARAGARSMTATSGPGIDLMTETFGLVATSETPLVICDVMRAGPSTGMPTKQEQGDLNMLLYGGHGEIPRFVVAPTTIAECFHKTVEAFNLAEKYQTPVYLVSDLALAVTEQTFAPEEFDMDAVEIDRGNVVDEDSIDEYLDEQGRFQPHYDAADGVSPRAFPGTTAGAHMSTGLEHDELGRRTEDTEERIDQVEKRQRKVETAQNEEDWSPREFGDPDADTLVLSWGSNEGAIVEAMDHLETEENLSVRFLSVPYMFPRPDLSDAIEAAEETVVVECNANGQFADVVEHDVLTRVERVTKFDGVRFDADELADAIRDVAADADEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W432</accession>
    <name>R4W432_9EURY</name>
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        <submittedName>
            <fullName evidence="2">MaoC domain-containing protein dehydratase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_04665</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04665"/>
    <dbReference type="EnsemblBacteria" id="AGN00882">
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        <property type="gene ID" value="L593_04665"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.953"/>
    <dbReference type="eggNOG" id="arCOG00775">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777564_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045672">
        <property type="entry name" value="MC_hydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19315">
        <property type="entry name" value="MC_hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="363" mass="40050" checksum="4FB5C7FC0974969D" modified="2013-07-24" version="1">MIPMTDWTDPETFATALDRAATREKGSYFEDFAEGETIEHDPGLRLTRSGAEQWTSQTLNHDPAYWRSDAAEARGFDEPPIHPDYLLAATMGPSVEDLSEKGGYFLGRDDVRFTQDAVYPGTELHVESTVLATRTSGSRPNYGIVTWETRGLDAPGGETLCTYERTNMIPRREPIETDGGELEDTSATDPEDDPAPDLPEDLLAPDGEHFEDFETALEAAEERADAAVAYRHERGRTMDAVTVAELPLSTLNTARQHHNEAAMAHSPSGEIVAYGDVTRSTALGHARSDEATWREVGASEERFHDFVTVGDTIYGFTRVLEADGGPGPSHVGEVSFEHVAFDQDERPVYSGTRTALIERRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W479</accession>
    <name>R4W479_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="AGN00967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN00967">
        <property type="protein sequence ID" value="AGN00967"/>
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    </dbReference>
    <dbReference type="GeneID" id="16181201"/>
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    <dbReference type="eggNOG" id="arCOG02209">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="209"/>
        </location>
    </feature>
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        <location>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
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        </location>
    </feature>
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        <location>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
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        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="339"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="508" mass="54774" checksum="02BCEA56024C2D12" modified="2013-07-24" version="1">MTTAREKHLTTLLTGAGLVTVGKLVGSFTTLGERVLIGRVLSPEAYGEVSVGLALLAFATTGALVGFSQGVPRYISRFDDEVDRRGVWVSGILVTGAVALVLTAVLLLSVEWLTETLLARADSPAMLALFVLALPFVVGMKITVAAIRGHNNAIYRIYAQDLTYPLTRIVLLVALLFAGFNVLAAGYAYLVAAVLSFAVSLVLLHRLTALRGEVRTHVKEIGRFSLPIVISGVLTVLLTRTDTLMLSYFRTTYEVGQYAAAYPIANGLIIVISSFGFLYLPLASRLDADDEHDEIDSIYETTTKWIYLVTFPALLTFVLFGGDVVEIFFGSAYSEAPIALAILSVGFFTNAVGGRNRETISALGVTSYLLVVNGAAFGINVVLNLWLIPEYGLVGAAVASAIAYGILNATACAILWRKYGITPFSRWSVRTFLVLPLTLLPPAYVVSQYVSLSIVTLLPWLVAVGLLSIAVVALTGCLQPEDEIVLEFLEQTTGVEIPLVRRFIPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4B5</accession>
    <name>R4W4B5_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">L593_05390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445921.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05390"/>
    <dbReference type="EnsemblBacteria" id="AGN01027">
        <property type="protein sequence ID" value="AGN01027"/>
        <property type="gene ID" value="L593_05390"/>
    </dbReference>
    <dbReference type="GeneID" id="16181906"/>
    <dbReference type="KEGG" id="sali:L593_05390"/>
    <dbReference type="eggNOG" id="arCOG08617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064090_2_0_2"/>
    <dbReference type="OrthoDB" id="65122at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="273" mass="29294" checksum="34D446FD178302CE" modified="2013-07-24" version="1">MSERATDRSTRPTLEIARFDAGRRLKGSFALSVGIAFFALLFTSFFPSVEQIDVEEYTEAMPELFRELFNIQAMTSVEGFLAVEVYQFIWVLLLPLYVAYLGAGIVAGDADRDRLDVLLSLPVSRSRLLAGKSAALAPVIVLPNVIVPPVVYVGVLALGESIDPMALVAVHALSVPFFLACGAIGVLASVIVLDGDLARRVALAAIFALYLLESLSVVAEQDWIGAISPMRYYDPTEIMVDGAYDLVGVAALLAIAGVALGIATVRFQRVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4G6</accession>
    <name>R4W4G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446011.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05840"/>
    <dbReference type="EnsemblBacteria" id="AGN01117">
        <property type="protein sequence ID" value="AGN01117"/>
        <property type="gene ID" value="L593_05840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181508"/>
    <dbReference type="KEGG" id="sali:L593_05840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1196"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="360" mass="40123" checksum="032955F315B0EBE6" modified="2013-07-24" version="1">MSTHNTSTEDTTMHNTSDPILELRNTEVVFEMSRGVSRVLDNVDLDIQRGEILGIVGESGSGKSMLASAMLDAVVDPGVLSGQITYYPDDRDPVNVLGLSDEELRKLRWEDISMVFQGAMSSFNPTMSIKGHFVETLEAHDYDREEGMDRARQLLADLYLDPERVLKSYPHELSGGMRQRALIALSVVLEPDVLVMDEPTAALDLLMQRSILSLLQGLKDKYDLTMVFITHDLPLVAELADRMSVMYAFELVEKGSTEEILRNAAHPYTRALLNSTPNLDAPLSEMRSIDGSAPDPVNVPEGCSYHPRCPLADEQCTAEAPDFHEVSDTHRVECFHWEDASEAIPFNIDQQQATPEEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4N8</accession>
    <name>R4W4N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-type ATPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446121.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06400"/>
    <dbReference type="REBASE" id="65149">
        <property type="entry name" value="SspHBMcrBP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01227">
        <property type="protein sequence ID" value="AGN01227"/>
        <property type="gene ID" value="L593_06400"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06400"/>
    <dbReference type="eggNOG" id="arCOG03779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513527_0_0_2"/>
    <dbReference type="OrthoDB" id="30913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="223"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="524" mass="58344" checksum="0AC8A4413E9898C1" modified="2013-07-24" version="1">MAYDGPKIFLAPYGSNAAQENFQKTVLEGISAERIASFTDFPNEETDVVRLWGTKSTVKGSWRKIEPGDYLLFYLDGSYTHSAEVLGTEENEELGRDIWPNFDEEPWSQIIYLEAPVAIDVPSENVHELAGYDRDHPQGFSSLHDLGVGGIRGQYGSVEAFANGGDPIERRSAVRAGVSDADSAIDVHREPEVDFGDNLLDGLYFPDGRGEEILDQVASAFDSGKHVIFTGPPGTGKTELARRVCSELVEDHPDVYSGHQITTATADWSTFETVGGYMPTESDGENLSFEPGQVLRRFKQDGQQRNELLVIDEINRADIDKAFGQLFTLLSGQSVQLPYRKQGEEIVVRPADADDGEAADHEYVMPASWRLIATMNTYDKTSLYELSYAFMRRFSFVHVDAPTVPEDREDRLALLAEYTAAWDLDPDEAILDAVAEIWRVLNSGNEDRKIGPAIVQDILRGIEHGPHRDERTAITAAVANYVLPQLEGTRRQETIVNRLSRVEAVDRTRLIDLSEDVLQVEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5A6</accession>
    <name>R4W5A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01612">
        <property type="protein sequence ID" value="AGN01612"/>
        <property type="gene ID" value="L593_08335"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08335"/>
    <dbReference type="eggNOG" id="arCOG09028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2857257_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6829" checksum="8D6D10142D047601" modified="2013-07-24" version="1">MWERQTSIMTIDATGGGMAGSAVINSSTCAEDTLAAHLRAALERTEDPAARFHIREALQLLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5M8</accession>
    <name>R4W5M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446726.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01832">
        <property type="protein sequence ID" value="AGN01832"/>
        <property type="gene ID" value="L593_09435"/>
    </dbReference>
    <dbReference type="GeneID" id="16182708"/>
    <dbReference type="KEGG" id="sali:L593_09435"/>
    <dbReference type="eggNOG" id="arCOG06413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="22639" checksum="7BE3DAE9E0F73F24" modified="2013-07-24" version="1">MVDIDEAQAKDGAIVGAIAFVVGLIGSVLFVTPSSGDDVFKITASAMGQTQSQTMTWGSLGGSGTSKPETWKVAGWVYHKAHFASIDVNFSGFSSIGSNVSVNGSFVMDVPLLVQLLPIVLLGAAGFVLAERWDADDPKDAAINGAHVVAGYAPLAVLSTFLLSWSQSSSSSGISASVTVEPALVSALLFTGLAAPLVLGALGGVVNHEFGDDILEAIGQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Q5</accession>
    <name>R4W5Q5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446776.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09685"/>
    <dbReference type="EnsemblBacteria" id="AGN01882">
        <property type="protein sequence ID" value="AGN01882"/>
        <property type="gene ID" value="L593_09685"/>
    </dbReference>
    <dbReference type="GeneID" id="16182582"/>
    <dbReference type="KEGG" id="sali:L593_09685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1994"/>
    <dbReference type="eggNOG" id="arCOG04667">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880986_0_0_2"/>
    <dbReference type="OrthoDB" id="99527at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043927">
        <property type="entry name" value="DUF5778"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19090">
        <property type="entry name" value="DUF5778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="15026" checksum="5691F97B6D24733C" modified="2013-07-24" version="1">MDDVRDPDLYQRTQRLLEPGEIELDGLIVHTDLPSEEDIEMLDATLAVGDVIADHAGYEPNETYVYSGNDDTDFSSNQHQGLTLDGDEFVWECQQLLRAGSYDLVFYFEADADREAIAEAASEETGFPTTAVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W8</accession>
    <name>R4W5W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10185"/>
    <dbReference type="EnsemblBacteria" id="AGN01982">
        <property type="protein sequence ID" value="AGN01982"/>
        <property type="gene ID" value="L593_10185"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10185"/>
    <dbReference type="eggNOG" id="arCOG10137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736490_0_0_2"/>
    <dbReference type="OrthoDB" id="88687at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16767" checksum="E468DD56779B1F2E" modified="2013-07-24" version="1">MTLGSEQSRYDARYRIRQRTRDAMLDFPLLVERLAERDREQVFDPETGGITDAIVDAIAFCYLGAADVAADPERLLAAGVRRAERERRGPDCPLLDVDVSVEATDDERVDHIAQCVGDGAIHELDERDLRALARLLADRDDVSLADLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W622</accession>
    <name>R4W622_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446961.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02067">
        <property type="protein sequence ID" value="AGN02067"/>
        <property type="gene ID" value="L593_10610"/>
    </dbReference>
    <dbReference type="GeneID" id="16182052"/>
    <dbReference type="KEGG" id="sali:L593_10610"/>
    <dbReference type="eggNOG" id="arCOG08021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187344_1_0_2"/>
    <dbReference type="OrthoDB" id="125915at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="8200" checksum="22233E747E9CD16F" modified="2013-07-24" version="1">MAVVESEARRAMCSEIESPTAKLVYLSLAEQGRASVQELQDRLGEPRITLYGVLDSLVDCGVVEVDRGSGGSVYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W698</accession>
    <name>R4W698_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445122.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01375"/>
    <dbReference type="EnsemblBacteria" id="AGN00228">
        <property type="protein sequence ID" value="AGN00228"/>
        <property type="gene ID" value="L593_01375"/>
    </dbReference>
    <dbReference type="GeneID" id="16182633"/>
    <dbReference type="KEGG" id="sali:L593_01375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.280"/>
    <dbReference type="eggNOG" id="arCOG01876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040013_3_2_2"/>
    <dbReference type="OrthoDB" id="21172at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="360" mass="40982" checksum="615BE084DAF35301" modified="2013-07-24" version="1">MTKEQFRPEDHPNDHFLMTTVVGSYPKPKWLNRVRERCHHQEDVDQVELEPVDEETLAEAEDDAARLITKEHERAGLDVVVDGEMRRTEMVEYFAERIEGYEFNGPVKVWGHNYFDKPSVVSEVEYGEQWLVDEYEFTSEVADRPVKVPITGPYTLARWVFNEHYETTADLANDLAELVNEEVEKLVDAGARYIQIDEPALAQHEDDHAIVGEALERVVEDLPEDVRIGLHVCYGDYSRIYPEILEFPVDEFDLELANGDFEQVDVFKEPEFTADLAMGVLDAHVAEVESVEEIKENIKKGLEIVPPEQLVVSPDCGVKLLPRNAAYQKLENMVQAAREVEAELDAGEIDVLQAPASADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E4</accession>
    <name>R4W6E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445227.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01910"/>
    <dbReference type="EnsemblBacteria" id="AGN00333">
        <property type="protein sequence ID" value="AGN00333"/>
        <property type="gene ID" value="L593_01910"/>
    </dbReference>
    <dbReference type="GeneID" id="16179944"/>
    <dbReference type="KEGG" id="sali:L593_01910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.388"/>
    <dbReference type="eggNOG" id="arCOG04907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149107_0_0_2"/>
    <dbReference type="OrthoDB" id="122708at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040493">
        <property type="entry name" value="DUF5518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17647">
        <property type="entry name" value="DUF5518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="12661" checksum="4A9134A1A7E3F8CF" modified="2013-07-24" version="1">MGEGDTLLNAVIGGGFTIVTGNLIPLAPVVGGGIAGYLEGGSREDGVRVGVYAGLISLIPVLVFAFLVSSLFGLFGLFAGEVLPGIAGTIFFVVALAFGVLYFVGGAAIGGWLGNYVKYETDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q1</accession>
    <name>R4W6Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447351.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12590"/>
    <dbReference type="EnsemblBacteria" id="AGN02457">
        <property type="protein sequence ID" value="AGN02457"/>
        <property type="gene ID" value="L593_12590"/>
    </dbReference>
    <dbReference type="GeneID" id="16181194"/>
    <dbReference type="KEGG" id="sali:L593_12590"/>
    <dbReference type="eggNOG" id="arCOG05706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_2"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="30525" checksum="4A6D73200A9C58DA" modified="2013-07-24" version="1">MIGHPTVPDADSLYVDAGGRRLHYLRAGDPDDPAVVLLHGSGIDDAALSWHHAIPALADDFRVYAPDWPGYGESPDPDAEPNGAYYRAVLQDFLAAIPVERPSLVGLSMGGGAALGVAIESPQAVRSLVLVDSYGLRDAVPGGSAAYVLANAPFARTIGQQIAGVLPGAARSTIAPFVADADDLDPAFLSAVSERLDDPGAGRAFVDFQRAEFSPDGVRTHYEDRLEDLAVETLVVNGASDPLIPLAWAEDAAARIPAGSLSVIEDCGHWPPRERPDAFLDEVAPFLASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W2</accession>
    <name>R4W6W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terminal quinol oxidase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447446.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13065"/>
    <dbReference type="EnsemblBacteria" id="AGN02552">
        <property type="protein sequence ID" value="AGN02552"/>
        <property type="gene ID" value="L593_13065"/>
    </dbReference>
    <dbReference type="GeneID" id="16180375"/>
    <dbReference type="KEGG" id="sali:L593_13065"/>
    <dbReference type="eggNOG" id="arCOG03070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_8_2_2"/>
    <dbReference type="OrthoDB" id="118421at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14119" checksum="BAE20ACFC7296D84" modified="2013-07-24" version="1">MAFESTGAGLALLLGRLAFASVLGFLAVGNLQDMDETIAYAKSKGAPLAGLTVPLSSLALLAGAAAIALGAFPLVGALAIGAFLVGVTPIMHDFWTQEGMDRQNEFIHFLKNVGLGGGAAVFAALATLSWPYALGLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X7</accession>
    <name>R4W6X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447471.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13190"/>
    <dbReference type="EnsemblBacteria" id="AGN02577">
        <property type="protein sequence ID" value="AGN02577"/>
        <property type="gene ID" value="L593_13190"/>
    </dbReference>
    <dbReference type="GeneID" id="16180468"/>
    <dbReference type="KEGG" id="sali:L593_13190"/>
    <dbReference type="eggNOG" id="arCOG02767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073769_0_0_2"/>
    <dbReference type="OrthoDB" id="95484at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="26613" checksum="F6A017A71E47B64D" modified="2013-07-24" version="1">MNSEVATDRTGTAADSRFREAVLSFVLGASGYVGIQLTALVLVVGAIGFAGSLTDMEANVVAAVGTGVGAVFFALVYFEHSRHDASFLDLDPPGLRDVGYVVLGVVVLVGALFAISIVANALGLGLSNHSLADTAESADPLIVALLIPASILFVGPGEELVFRNVVQKRLGESFSTWGAIGLASVAFAAIHFPAYATGSLSQILASLVVVFTLSILLGWLYVRTEKLFVPALTHGIYNAIQFTILYVEVASVGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W729</accession>
    <name>R4W729_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445587.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03710"/>
    <dbReference type="EnsemblBacteria" id="AGN00693">
        <property type="protein sequence ID" value="AGN00693"/>
        <property type="gene ID" value="L593_03710"/>
    </dbReference>
    <dbReference type="GeneID" id="16182548"/>
    <dbReference type="KEGG" id="sali:L593_03710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.753"/>
    <dbReference type="eggNOG" id="arCOG09395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037493_0_0_2"/>
    <dbReference type="OrthoDB" id="48757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="35329" checksum="E0FF0AFE351B6EC6" modified="2013-07-24" version="1">MTRTDVLPRDAIRSIDDPTFASVHHGDPTDEAFVVDGDPPRAYPTRILDGHEIVNDVHSGVADHDAVDAGSGTGGSAVPIAVTWCPICASGAVYDRRVGDRTLTFGVSGVLVDDALVMYDRETESEWRQTTGEAIAGDLEGTTLDALSVAVMPVGEFLEEHPDGEVLQPHRVQGDPAEALRTTYESKRYRGYHLADDFGLRAMRGEGTERSWDRSDFGPKTPVIGIDRGDVAVGYPLPVVEDADGVLRDSVGSESIIVVAADGRLHAFLDPGFSVERRDGGLRGDGTTWDPATGESEDGRQLERVVARHLYAFAWQDAHGPDSFYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W741</accession>
    <name>R4W741_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH dehydrogenase, subunit M (Ubiquinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445607.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03810"/>
    <dbReference type="EnsemblBacteria" id="AGN00713">
        <property type="protein sequence ID" value="AGN00713"/>
        <property type="gene ID" value="L593_03810"/>
    </dbReference>
    <dbReference type="GeneID" id="16180660"/>
    <dbReference type="KEGG" id="sali:L593_03810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.773"/>
    <dbReference type="eggNOG" id="arCOG01538">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_2_2"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="137"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="515" mass="54670" checksum="5AA441330E13A43D" modified="2013-07-24" version="1">MIIEALLAVALVGGFAVLLAPNRLAGKLAFGISLGPLLGSLWMFWQFDGDGNLMFDSAARSFESSLSGTTVLSMGPWDIQWLAAVDGISLPLVVLSTILTTLAIVSAWTPIDERQSQFYALVLFMEAALIGVFTQLDFFVWFVFWEGVLVPMVLLIGVWGGPRRKYAAIKFLVYTNVASAVLFVGFLGLLAGLEGSITSFALPEISQAIHADQLQSVGPFSAEELATISFFAMFAGFAVKVPIVPVHTWLPDAHVEAPTPVSVLLAGVLLKMGTYALLRFNFTMLPEVAAANAELIAVIAVISILYGAMLALAQRDLKRIVAYSSVSSMGYVILGLVAYTIYGVGGATFQMLSHGLISGLLFMTVGVIYNTTHTRMVGDMSGLADRMPIASWVFVAGAFGYMGLPLMSGFAAELFVFIGAFGAAGLDYSPVFTAAAMFGIVVVAGYLLAAMQKSLFGPFELATDYEIGRAPFHDVAPLFVLLGLIVVLGVAPDVVFNMVEDATQPIIEAANGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W753</accession>
    <name>R4W753_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03960"/>
    <dbReference type="EnsemblBacteria" id="AGN00743">
        <property type="protein sequence ID" value="AGN00743"/>
        <property type="gene ID" value="L593_03960"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.805"/>
    <dbReference type="eggNOG" id="arCOG06224">
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043829">
        <property type="entry name" value="DUF5806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19122">
        <property type="entry name" value="DUF5806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="48214" checksum="DB4C89EFFAA10D95" modified="2013-07-24" version="1">MTEESSGDADERDADEGPADDEEHADDEFLDERGLAPARSEEEPDVEAAKAELEAVGTGPDDEDEDPDRDDGEVSAHDGDEGSAHDEGREVEHDDGVGAEQGLGVGPERDDGEALGRDDDVEGEGPDADDSPAIEIVDESDEGDDDPTPESGTDAEAPKAAGEPAAAGESTAAEAPDDGAEDETEGDDDPNPEDLVRDPDEPQVTSSLEDEVDTDERAADDDATDDADAADEEAAAESAAPAGATADAAQAEPDTEAAEEETDASDDSAAADEPDHQPGVPSDVQKYDRFKKVDGSQYDRVNEFLRDRTYITAREWAIARLCSDFRTETGVEMTKIGENLPELVPFMTDTYTPQAVNQARSSFEDKVRTAGATFLYGAMSDFFTAEELDDVMYEATEVAKFLLEVEGVELSVEDELEAEDRISAVMREVRSSSAELRHERCPECGAELSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W756</accession>
    <name>R4W756_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04010"/>
    <dbReference type="EnsemblBacteria" id="AGN00753">
        <property type="protein sequence ID" value="AGN00753"/>
        <property type="gene ID" value="L593_04010"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04010"/>
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    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="400" mass="41738" checksum="080417702DD9DB36" modified="2013-07-24" version="1">MTGDHDSRAPALRVEGLAKTFGEGEGAVRAVDGISLSVDHGEVVGVLGPNGAGKTTTIKSMLGLVLPDDGTVEVCGIDVHDEPAAAYRHVDAMLEGARNVYWRLTVEENLRYFAGLGGDDPDDLTDRHERLLESLGLADEADTVVNDLSRGMKQKVSLASTLARDVDVVFLDEPTLGLDVESSIELRSELRRLAERENVTIVLCSHDMNVIEAVCDRIVILQDGRVIADDPMADLVDVLREKRFSVVTDGPIDEDLERDLADRFGATIRESDPSERGGDTEVGQSVTIDATGIGAEDAAALLDAVRDAGHSLQDVETAEPTLEDVFLRVTGTGDGGDGDGSEPGGNAHPSGSRSGDANGSGSGDANGGRSGDGSGDESAATNDDPEPAAAGTGVIADGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W759</accession>
    <name>R4W759_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="8">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gatB</name>
        <name evidence="10" type="ORF">L593_04060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445657.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04060"/>
    <dbReference type="EnsemblBacteria" id="AGN00763">
        <property type="protein sequence ID" value="AGN00763"/>
        <property type="gene ID" value="L593_04060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180780"/>
    <dbReference type="KEGG" id="sali:L593_04060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.825"/>
    <dbReference type="eggNOG" id="arCOG01718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_2"/>
    <dbReference type="OrthoDB" id="21200at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="9">
        <location>
            <begin position="347"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="501" mass="55201" checksum="573DB90EA46FCA4A" modified="2013-07-24" version="1">MSTQAAATEELAVVIGLEVHVQLETDTKIFCGCSTEPADEPNTRTCPTCLGLPGALPVLNEGAVEAAVKVGKAIDATIPETTRFHRKNYFYPDLPKNFQITQYDEPICQDGELEISHEGERRVVGIERAHLEEDPGSLRHVGGSIDTAEYTLVDYNRAGTPLLEIVTEPDFRAPQEVRAFLAKLTEVLEYLGVFDAERDGSLRVDANISIVDAEEVDDETGEISIETLEAANRTEVKNISSHKAAEQALAYEVTRQKNAISRGREVEQETRHWDEGKGVTVSMRSKEAEKDYRYFEEADLPPLEVADWKEEIDIPELPDARRERFREEYGLGQEAADKLTSTKQVADFYERVAADFEPDLAATWVADELLGELNYRDMAITDVEGRLDEFHRLVELVAAEEITAKNASEVVLRTMLDEGDETGEGPGPDAIVEAEDLGKTDEGEVEAAVEAAIDENPDAVADYHDGDDGAINFLVGQVMQATGGSADPGTVNQLLREELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W790</accession>
    <name>R4W790_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447636.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02742">
        <property type="protein sequence ID" value="AGN02742"/>
        <property type="gene ID" value="L593_14015"/>
    </dbReference>
    <dbReference type="GeneID" id="16181014"/>
    <dbReference type="KEGG" id="sali:L593_14015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2867"/>
    <dbReference type="eggNOG" id="arCOG01449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079807_0_0_2"/>
    <dbReference type="OrthoDB" id="38672at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046260">
        <property type="entry name" value="DUF6293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19810">
        <property type="entry name" value="DUF6293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6293" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="35335" checksum="98AE296DA36D41DC" modified="2013-07-24" version="1">MQTHVVPVGFDYDRLIAPLVRDQLDVDRAILLEGAVGSEANVEYSRRLSTKLEQDFRNLLGATTERVVLADVYDYDAAFEQAYELINDELDRGNEVWVNVSAMPRPVSFAFATAAHSIMVEREADREKIHTYYTAPEKYLETELAEELREQRALLEDVRSAIEDDDVDADVATAVADERIAQRLDATEDLLAEFDERGTTIGAKEIGDSHIVELPVASFSNVKPFEEVILYKLGEAGVFDSVSELAKALADELDEEYTDSFRSKVIYNVDRLGPGGKGYIEQEHHGKSHRTRLSRIGELWVRAHSDSPPAEAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W799</accession>
    <name>R4W799_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447656.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14115"/>
    <dbReference type="EnsemblBacteria" id="AGN02762">
        <property type="protein sequence ID" value="AGN02762"/>
        <property type="gene ID" value="L593_14115"/>
    </dbReference>
    <dbReference type="GeneID" id="16181077"/>
    <dbReference type="KEGG" id="sali:L593_14115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2888"/>
    <dbReference type="eggNOG" id="arCOG04116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OrthoDB" id="19750at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="633" mass="68211" checksum="B225A59016159495" modified="2013-07-24" version="1">MHVVPDTSVVVDGRVSERIAEGAFADATVSVPEAVVAELEAQANEGHESGWDGLSELQRLADLADDGDIDLEYVGERPDAVERGHASEGEIDALIREIASDLDATFFTSDVVQAEVAEAKGIDVDYVASRTESMADLSIEDYFDETTMSVHLRAGTKPMAKRGHVGDLRYEAIDDEVLDTESVRDLAHEIENAARQSDQGFIELSEPGMTIVQYRDYRIALAEPPFSDDVEITAVRPIVQTDLEDYEHDEELKERLLERQRGILISGAPGAGKSTFAQAAASFLAEHDVVVKTMEKPRDLQVGPEITQYTELGGEMSKTADSLLMVRPDYTVYDEVRKTDDFEVFADMRLAGVGMIGVVHATRPIDALQRLVGRVELGMIPQVVDTVVYIEAGEVETVYDVQTDVKVPHGLTEEDLARPVIVVSDFETGEPAYEIYTFNRQVVTVPLQDDEGGAGGRSEQGVERIAKQEIEREIRSIARGHVEVQLKGSNDAIVYVEDDDISTVIGKGGGRISEVENRLGISIDVRTHDENPANRPGAGGGGTSGAGGAGGTSGSGGGGREGQIVEPEITSRHVVVPVDGHAGETVEVQAGGDYLFTATVSRGGEVQVSRGSAIAEELEDAIDRKQQITVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A6</accession>
    <name>R4W7A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AGN02777.1"/>
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        <property type="component" value="Chromosome"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHP04031_Htur1727"/>
    </dbReference>
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        <property type="entry name" value="PaaB"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04031">
        <property type="entry name" value="Htur_1727_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="13913" checksum="501883314CD98A51" modified="2013-07-24" version="1">MVETADRSRVGEEPRGDPTREWEVFVRENSDDPLRHVGSVSAPSAEVAHEQSSRLFAWYADDLWLCPADEVRRFSTHDLAEEESSPESEESSPTPEDRSSSEAVVDEDETATYDGADEPRVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C5</accession>
    <name>R4W7C5_9EURY</name>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00893">
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        <property type="gene ID" value="L593_04720"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_04720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.965"/>
    <dbReference type="eggNOG" id="arCOG04759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130786_0_0_2"/>
    <dbReference type="OrthoDB" id="111320at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043835">
        <property type="entry name" value="DUF5811"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19128">
        <property type="entry name" value="DUF5811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="13931" checksum="25C275DE33254FD3" modified="2013-07-24" version="1">MNGNTPYAGQPGTTQAGKRANDDLVDLSSDEKRRFRQDVTRIATRTREFLPDEYAIDADISHSAGGPQGRVAVQPPVGHPVTAGFTPNEEDFDAENVVDDEDVGEVARGLAASAALQVKQAVANNVTPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E4</accession>
    <name>R4W7E4_9EURY</name>
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        <recommendedName>
            <fullName evidence="6">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="6">GPR</shortName>
            <ecNumber evidence="6">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="6">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">proA</name>
        <name evidence="9" type="ORF">L593_14630</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447756.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14630"/>
    <dbReference type="EnsemblBacteria" id="AGN02862">
        <property type="protein sequence ID" value="AGN02862"/>
        <property type="gene ID" value="L593_14630"/>
    </dbReference>
    <dbReference type="GeneID" id="16181382"/>
    <dbReference type="KEGG" id="sali:L593_14630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2987"/>
    <dbReference type="eggNOG" id="arCOG01253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_2"/>
    <dbReference type="OrthoDB" id="38901at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 6" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="11"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="223"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="496" mass="53470" checksum="722E8A1B29A4C7F2" modified="2013-07-24" version="1">MSEQLEKPTAEKVADAERAALSLAKCSDRMRSAALHEIADAIAANHDEILAANERDVAEAEELLEAGEYTQALVDRLKLSESKLESIEEMVRSVAGQDDPLGDTQTARALDDGLELYRVSVPIGVVGTIFESRPDALVQIAALCLRSGNAVILKGGSEASHSNRVLYELIEDATAGFAVDGDEETGDEDAGAHAAEEDAGDDDAADDDTAEDDAGDRHEADDELPDGWAQLIEARADVDTVLEMDDAIDLVMPRGSSEFVEYIQQNTHIPVLGHTEGVCHVYVDDAADLSMASDIAFDAKVQYPAVCNAVETVLVHEAVADEFLPEIAERYREADVEIRGDEQTRAIVDVAAASEEDWDTEYGDLIVAIRVVDSIDDAVDHVATYGSKHTDSIVTEDTGHARFFMRSLDSASVFHNASTRFADGFRYGLGAEVGISTGKIHARGPVGLEGLTTYQYYLEGDGQIVGTYAGADAKPFRHEDFDGEWRPGQLSSDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X3</accession>
    <name>R4W7X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446177.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06680"/>
    <dbReference type="EnsemblBacteria" id="AGN01283">
        <property type="protein sequence ID" value="AGN01283"/>
        <property type="gene ID" value="L593_06680"/>
    </dbReference>
    <dbReference type="GeneID" id="16181856"/>
    <dbReference type="KEGG" id="sali:L593_06680"/>
    <dbReference type="HOGENOM" id="CLU_2748363_0_0_2"/>
    <dbReference type="OrthoDB" id="144596at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7733" checksum="41A90B34A423E28D" modified="2013-07-24" version="1">MSEDRADRGANETAVPESHAGTVESESETAQTGPLRRVWQVVIVAGGWVVDTFRGHSGARDLQRRRNQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z7</accession>
    <name>R4W7Z7_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Glycosyltransferase group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07030"/>
    <dbReference type="EnsemblBacteria" id="AGN01353">
        <property type="protein sequence ID" value="AGN01353"/>
        <property type="gene ID" value="L593_07030"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07030"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="353" mass="39096" checksum="D0740EA4C20B7FFE" modified="2013-07-24" version="1">MEPEMEAEASTAPDTGQSPEIAESIAADAPEDVVTSIVLPAYNEVGNLRPLVEEIVAVVESEEMAAYRPVEILIVDDGSTDGTAETIRELTDEFDAVAGVFLRRNFGQSAALCAGFDTASGEYVVPMDADGQNNPVDVPMLLDRLEDGYDCVSGWRKDRDDPITKTIPSGIQTYLARFTGPDIHDFGCTLKAYRREAVDELNLRGEGHRYIPAKLYDRGYKITEEPVDHRPRTHGSTKYGAGRLVRGFVDLAFNIFWNKYSMRPMHLMGGLGLFLLAIGGVVGTHALFMKYVLGDSLLPHLPRLIFAVALIIFGFQLLMFGIMAEMLTKIHYKGEVPYRIQSVERGEKQNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W841</accession>
    <name>R4W841_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01473.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07640"/>
    <dbReference type="EnsemblBacteria" id="AGN01473">
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        <property type="gene ID" value="L593_07640"/>
    </dbReference>
    <dbReference type="GeneID" id="16182176"/>
    <dbReference type="KEGG" id="sali:L593_07640"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_2"/>
    <dbReference type="OrthoDB" id="83765at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="15074" checksum="4FD23020399150C2" modified="2013-07-24" version="1">MPIQDLAREDVVTTGPETPVPDVARMMDEETVGSVVVTEGDQPVGIITDRDLALRVVAESANPADHTAADVMSTDLHTATPDTGFYQAAEEMRANGIRRLPLCDDDGSLVGIITSDDLNELLADEHQELSTVLQAQRPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A1</accession>
    <name>R4W8A1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446497.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08290"/>
    <dbReference type="EnsemblBacteria" id="AGN01603">
        <property type="protein sequence ID" value="AGN01603"/>
        <property type="gene ID" value="L593_08290"/>
    </dbReference>
    <dbReference type="GeneID" id="16182358"/>
    <dbReference type="KEGG" id="sali:L593_08290"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1699"/>
    <dbReference type="eggNOG" id="arCOG04632">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010179_1_0_2"/>
    <dbReference type="OrthoDB" id="6746at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="663" mass="76250" checksum="3D1F88B87DDB9EAF" modified="2013-07-24" version="1">MSTPDRYQAQQQARRLERPVAAARELAQTLGLEPVPVNYWIVDYDEMNELIAYDGFQTRYPHWRWGMKYDRQQKQDRYTGGKAFEIVNNDSPANAFLQESNPLADQKAVITHVEAHADFFANNQWFGLFPGEEGGATAMLERHATRIREIMEDPEIDREAVESWIDTVLTLSDTIDQQRAFSRDLGADGDAADEIDLADQLDDLDIGDEVRAEVFDEEWLEAQAEEELLDRDAPEADVLAFLREHGMAYDAEAERAVEFEEWQREVLELLRAEAYYFAAQRMTKVMNEGWAAYWESIMMAGETFADADEFVTYADHMAKVLASSGLNPYALGLELWTYVENRTNRQEVLERLLAVEGVDWRSLEATVDWDAVQAALEPPEAVAAAGGTDLEDVAALPDHLIDREEIEAAREGAFDPSEESWRLLSYEGMARRHYSLVRPEHRRFLRDVSRDELEEIARYVFDQDRYATIEDALADVDFTAGWDRMREIRESHNDVTFLDSFLTEEFVATNDYFTFEYSRAAEEHRVASTDPADVKKKLLLQFTNLGKPTITVEDGNYGNRNELLLGHHYNGVALDLAQAERVLERTFELWGRPVNLATIVKEVDEHDVEVARRRSREPDPEESGKLLRYDGSTIEHRDMPWSEVDHLAADDVDYDTKPEEWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C2</accession>
    <name>R4W8C2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445413.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02840"/>
    <dbReference type="EnsemblBacteria" id="AGN00519">
        <property type="protein sequence ID" value="AGN00519"/>
        <property type="gene ID" value="L593_02840"/>
    </dbReference>
    <dbReference type="GeneID" id="16180352"/>
    <dbReference type="KEGG" id="sali:L593_02840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.574"/>
    <dbReference type="eggNOG" id="arCOG00839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_3_1_2"/>
    <dbReference type="OrthoDB" id="98598at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="16448" checksum="AA74D78909BD0040" modified="2013-07-24" version="1">MPTVRDLRPDDAVALTCLYEDYEWWADREVEGVRSALEDTDVAIGVTVDGRLAAAARVVTDFTYYAMVYDVIVAADRRGEGHGDRLLEAIVEHADLQELPRLALLCRRGLVPYYESVGFELFDPEIDVPEGGTEELVRMTYRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F6</accession>
    <name>R4W8F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN00619">
        <property type="protein sequence ID" value="AGN00619"/>
        <property type="gene ID" value="L593_03340"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_03340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.676"/>
    <dbReference type="eggNOG" id="arCOG02431">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_107614_1_1_2"/>
    <dbReference type="OrthoDB" id="88478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="15271" checksum="1386C0F026FA1682" modified="2013-07-24" version="1">MRVSVIGGGRVDEEDRERAEAVGRELAERGHEIVCGGLGGVMEAACRGAKEAEDPARTVGILPTDDSADANEFVDVPIATGMGNARNALVVGNGDAAIAIDGKYGTLSEIALALDRGSPVATLGSHDVEGAEPVESAAGAVTFVEDALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F7</accession>
    <name>R4W8F7_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01723">
        <property type="protein sequence ID" value="AGN01723"/>
        <property type="gene ID" value="L593_08890"/>
    </dbReference>
    <dbReference type="GeneID" id="16182536"/>
    <dbReference type="KEGG" id="sali:L593_08890"/>
    <dbReference type="eggNOG" id="arCOG03924">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171547_0_0_2"/>
    <dbReference type="OrthoDB" id="121852at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="13233" checksum="E002EDEA798052E5" modified="2013-07-24" version="1">MRLRQPTDFLILEALHTYGRNVATNLAKVTGKSRKNVNNRLPVLADYGLARKVGPAKQSGLYEITEEGRAAVDLRTQYDETDDFEALIEQRLENTTSDSTTVAARGEVDDEDGDDADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H5</accession>
    <name>R4W8H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09190"/>
    <dbReference type="EnsemblBacteria" id="AGN01783">
        <property type="protein sequence ID" value="AGN01783"/>
        <property type="gene ID" value="L593_09190"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG08127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157001_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11380" checksum="54FF8E9D3DAC88D5" modified="2013-07-24" version="1">MWFDVARLSAGVNVVLLAVLLAIWGRNYYELRSKHALGFTVFGLFLLAENATSLYMYVFHGVLADWFASSAVPPLAWKWMMALHVLETVGIAFLVWITWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J0</accession>
    <name>R4W8J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09415"/>
    <dbReference type="EnsemblBacteria" id="AGN01828">
        <property type="protein sequence ID" value="AGN01828"/>
        <property type="gene ID" value="L593_09415"/>
    </dbReference>
    <dbReference type="GeneID" id="16182700"/>
    <dbReference type="KEGG" id="sali:L593_09415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1938"/>
    <dbReference type="eggNOG" id="arCOG01622">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="167"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="39271" checksum="E68D5BBE60E84302" modified="2013-07-24" version="1">MTTHRVAFVGTGADPENPSSEGFAMAYQHASAYERLGNCELVGCADIVRENAEAFADRHDIDEDGVFEDYEEMVEAVDPDVVSVCTPPATHADIVVGLAESGVPDAIHCEKPMAMTWGGAKRMAAAAERADVALTFNHMRRFGDPFRDAKALLDDGAIGDLRRIEYSWGNFYDNGTHAIDMCNYFNDEYAPSWVIGQLDYREEEVYFGTHNENQMLASWEYENGVYGMATTGPASEIADGDWRLVGTEGVMDVHLTDEVAVRVRSLADDETESFEYDGLAGEGESCIDRAIADVVQSVETGEESELSARNALNATEIIFAGYESVRRRGRVDLPLDIEDNPLEEMVASGELSPRSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L2</accession>
    <name>R4W8L2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein L593_03790</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445603.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03790"/>
    <dbReference type="EnsemblBacteria" id="AGN00709">
        <property type="protein sequence ID" value="AGN00709"/>
        <property type="gene ID" value="L593_03790"/>
    </dbReference>
    <dbReference type="GeneID" id="16180687"/>
    <dbReference type="KEGG" id="sali:L593_03790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.769"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_0_0_2"/>
    <dbReference type="OrthoDB" id="103162at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="20259" checksum="3E4B0E63858D271E" modified="2013-07-24" version="1">MKSGARAVGVAESYARGADRSTLAGVVCRADRTVDGCAFATCTVGGTDLTDGIATVYDRLDREDVSYVLVAGVALAWYNILELESVAERVDRPVIAVTFEDSSGLESSLRDAFDGQALSERLERYRALPDRRATTVDGHDRYYRVAGIDPTEAARVLEHFTAEGGRPEPLRVARFVARAGDDLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M7</accession>
    <name>R4W8M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_09990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446837.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09990"/>
    <dbReference type="EnsemblBacteria" id="AGN01943">
        <property type="protein sequence ID" value="AGN01943"/>
        <property type="gene ID" value="L593_09990"/>
    </dbReference>
    <dbReference type="GeneID" id="16179857"/>
    <dbReference type="KEGG" id="sali:L593_09990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2058"/>
    <dbReference type="eggNOG" id="arCOG02245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_2_0_2"/>
    <dbReference type="OrthoDB" id="82502at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="43230" checksum="D27A9D05B8E110AB" modified="2013-07-24" version="1">MNPTVRRAGAFGAVGALALAAPLLGRAAILPFVLVAAGALAITHGPLFELFARPADREAGRLRGLFDFALAATVLGGLSVFGDLPVTVFAGSVLLVAIGNLGAEVVSVRSSVAPTLGFLAAGAAGAAVGIAGAALLAGDQIAAGSLLLLCLTGALVGALVRSMLFPRDEPPVLFTVGLVLWFLAAVDAGADPTAVAVAVAVMVVFGVLSYALDTASLEGVLAGVLLGLVTIVLAGYEWFALLLTFFGVGGLATKFRYETKLERGVAEENGGNRGGVNVLANSLVAVGAVCGLAAIEAGLVESPTALVPFAFAGAVATALGDTLSSEIGGAFDGTRLITSFEKVPPGTDGAVTWQGTLAGALGTATIGVLAFVAFPDVAMLGAVVVAIGGATGMTVDSVLGATAEGRLLGNAGVNFAATLAGALAAAGIAVALGLVTVTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q3</accession>
    <name>R4W8Q3_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446892.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01998">
        <property type="protein sequence ID" value="AGN01998"/>
        <property type="gene ID" value="L593_10265"/>
    </dbReference>
    <dbReference type="GeneID" id="16181743"/>
    <dbReference type="KEGG" id="sali:L593_10265"/>
    <dbReference type="eggNOG" id="arCOG08109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945324_0_0_2"/>
    <dbReference type="OrthoDB" id="100454at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="31207" checksum="886F1BC6C86C8508" modified="2013-07-24" version="1">MPHLDRLRQPEYTGENRCMACTYVNVLLTVCFTALLVAVAAQLLGPTPALGVGAVFAVLAAGSIWLRGYLVPKTPTLTKQYLPKSVLEKFGKAPDVGVAPAGAHDDQTAERDAAEEGVEAFDHEQLLLDAGAVEPCEDVDDLCLTDAFDRDWSAHLEALPDELDPETAAAEIGIDLGREHVHVQRYEKGTVVTEHDRPIVEWPSEAAMRLDAAGARTLADHSAQWDAFDFRQRAALVAGLRVFVEECPDGQPAELSEEQVESCCTSHTVVTLECADSGARLFEWQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W5</accession>
    <name>R4W8W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_10990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447037.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10990"/>
    <dbReference type="EnsemblBacteria" id="AGN02143">
        <property type="protein sequence ID" value="AGN02143"/>
        <property type="gene ID" value="L593_10990"/>
    </dbReference>
    <dbReference type="GeneID" id="16182333"/>
    <dbReference type="KEGG" id="sali:L593_10990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2266"/>
    <dbReference type="eggNOG" id="arCOG02841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_2"/>
    <dbReference type="OrthoDB" id="7900at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="38"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="418"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="450"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="686" mass="75131" checksum="52D642EB42E0C857" modified="2013-07-24" version="1">MATAEDDSVFERYRDQVDRPLSRLFREYGLPEIRWFSIGMVANVIARSASLLPPLVLGVAIDAVFVGDGQYSLPFLPQAWVPTSQSGQFWFSAALIVGAFVATGVFTWVYGVAANVFAHRVMHEVRTDTFARMQRLDMPFFDDKQTGEVMSVLNNDASNLEVFLDNALQNSARLGVMLLGIAALLFYLNPQLALVTLTVIPVMIAFTLWFMRAVEPRYVAQRSSVGDLNTRLENSLSGIELVKASATEDRETEKVTNASYDYFQHTMSVLKLNYLYRPGMELLAGIAFAATFVVGGIWLFSGPPAPFSGSLSVGEFVTFVFLTQRIVTPLAEVSNIVDQYENAKASSERVFGLMDVPVRIEDPEDPVVLDDPAGRVEYDDVDFAYPESALAAAEGTETAAAADGPGDGSEIDAEEAPERTADDAGRTTDDLVLEGIDFAAEPGETVALVGPTGAGKSTVCKLLLRLYDVTDGSIRVDGHDVRACTLDSLRESIGYVSQDVVLFDGTVAENVRYGRFDASREDVVEAAKMAEAHEFIENLPRGYDTRIGEDGVKLSGGQRQRLSIARTVLRDPDILVLDEATSAVDTETELLIQRSLDRLAVDRTTFVIAHRLSTIREADTILVLEGGQIVERGTHEELIDRDGLYASLWGVQAGEIESLPEAFLEEARERAAERPPADRSTRGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W938</accession>
    <name>R4W938_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446058.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06075"/>
    <dbReference type="EnsemblBacteria" id="AGN01164">
        <property type="protein sequence ID" value="AGN01164"/>
        <property type="gene ID" value="L593_06075"/>
    </dbReference>
    <dbReference type="GeneID" id="16181626"/>
    <dbReference type="KEGG" id="sali:L593_06075"/>
    <dbReference type="eggNOG" id="arCOG04735">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197985_0_0_2"/>
    <dbReference type="OrthoDB" id="130022at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6529" checksum="47BF8AE373C65538" modified="2013-07-24" version="1">MAKVSVEIPDELLEDLDEHVGEGKKFVNRSEAIRGSIRKTLDIFDDIDERQGRIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W964</accession>
    <name>R4W964_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06275"/>
    <dbReference type="EnsemblBacteria" id="AGN01204">
        <property type="protein sequence ID" value="AGN01204"/>
        <property type="gene ID" value="L593_06275"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1281"/>
    <dbReference type="eggNOG" id="arCOG00871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006041_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="509" mass="58450" checksum="2D04FAF174B9A17A" modified="2013-07-24" version="1">MDGKALLADEVGLGKTIEVGMILAEMHHRGTDEAVLILTPAQLAQQWQAELLEKFGLEFVCNYDDEFEGFGVHDRIIASIDTAKSDRHRSTVLARDWDVLVLDEAHYVKNEETDRYDLVDRLSYDYAFFLTATPIQNDVTDLYNVVSLLRPGLFGTREAFHNYFVENGQDTLVNRDDLQQRLRNVMIRNRREETDIDFTERNVTTTTFEPSPTERDLYEAVTNYVRGAYRESQGQKLVLMTLQKEVVSSPAALRGTIEKRLDDDEDEPPAHSDELEYILECADAVETPTKLKHLREITEEAAERVKKGRVVVFTQFRATQSLILETLREEGYTVHAFHGGHSSDEKEAIVERFEDEGGVLVSTDAMNEGRNLQFCNVMVNYDLPWNPMKVEQRIGRIHRIGQDREVYVFNVALEDTIEEYVLEKLYHKIDLFQQSVGELSEILTRLEETGRNFEDEVFERLVDADSDIELENDFDAMAVDLQEQRELADKVSDFNTGVFEGFDLGADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W976</accession>
    <name>R4W976_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447347.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12570"/>
    <dbReference type="EnsemblBacteria" id="AGN02453">
        <property type="protein sequence ID" value="AGN02453"/>
        <property type="gene ID" value="L593_12570"/>
    </dbReference>
    <dbReference type="GeneID" id="16182863"/>
    <dbReference type="KEGG" id="sali:L593_12570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2580"/>
    <dbReference type="eggNOG" id="arCOG02169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022005_0_0_2"/>
    <dbReference type="OrthoDB" id="8897at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="459"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="784" mass="83466" checksum="19215DD4F5A1FB00" modified="2013-07-24" version="1">MSTRSDGARRTAVGIDAARLFPSPRTLSLLGLVALTVGYCSTLYWVTTVAGGTAWLAGGIAVGLGLGVLFRGVQERRVLQIAGIGAVLGGVWYYTSAVPTIDPQMITRVTTDSVSMLSGISVLELAAVDVWIAALIPIPVFLTTYFALRGRYEYAVAAGGWLLVFLALTGDATLLETLLGTVGAVLALGFGELDRRDGAVTAADLLVALVAVMAVFAVVVPMVPSGSASALEPQGVGGDSGGASAQQATPLDEQLLDGDDVTAGGPINLSPDVRFVVESPSQQRWRVGVLDTYTGDSWTQSGLSSPYLGTLDGPPGSARTVLQQYQLRTEATDLPAAAYPIGVRNLDRNNVDVTSTGALTVDGRLPNGTNYTIESSVPTPTVNQLRTAGTDYPLSIEERYTGLPQYTVPERVSNLTDQVTSQSSNSFESARAIESYLEDNKEYSQNVSAPSGTLADSFLFEMDAGYCVYYAGTMATMLRTQGIPARVAVGYTSGQYVGNDTWVVRGTDAHAWVEVYFPDVGWVEFDPTPTGDVRDARRNAVETARTNESASVDVPESSGEELRFDQPENTTTTPTPNGTDGAPNGSTTNGTNTSDSDSGLDRGGLYSGVGYSIEGNGSSVDYVQPNVTTLGGTAADGENGSLPNATTERSGDRLLGGFDTLVIALLLVAGAVAGGRQAGLQHRIRDRGAVLWQRRRDPETDVERAMERLDALLARRYGARESGQTRREYRRRLPRSVDSRVHRAFELHERARYAGDIDRATADELVELVDDLARRDLPVLGDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W990</accession>
    <name>R4W990_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06660"/>
    <dbReference type="EnsemblBacteria" id="AGN01279">
        <property type="protein sequence ID" value="AGN01279"/>
        <property type="gene ID" value="L593_06660"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1360"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="25456" checksum="BEEEDC1D5368726B" modified="2013-07-24" version="1">MVSPEIEAAIEDGTRTAVVAVGSIEQHGPHLPVNMDTLDGDELARRIAVELGDALAAPTIRPGCSGHHMAFPGTITIPPETLMDVIRGYCRSLDEHGFEHVVLVPTHGGNFGPVKTVAPEIAREVDATVIPLADLDEHMQLLNDGLAKAGIDYQQDVIHAGAAETAIVLAIDEGLVRTEEMEPGPEGEFSTARLLSEGFDAITENGVLGDPREATAEAGETIVQTVVDAYVEAIEAERSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J7</accession>
    <name>R4W9J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447602.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13845"/>
    <dbReference type="EnsemblBacteria" id="AGN02708">
        <property type="protein sequence ID" value="AGN02708"/>
        <property type="gene ID" value="L593_13845"/>
    </dbReference>
    <dbReference type="GeneID" id="16182533"/>
    <dbReference type="KEGG" id="sali:L593_13845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2833"/>
    <dbReference type="eggNOG" id="arCOG03097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148450_0_0_2"/>
    <dbReference type="OrthoDB" id="108043at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043900">
        <property type="entry name" value="DUF5788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19101">
        <property type="entry name" value="DUF5788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="16728" checksum="9AC347907885F9BB" modified="2013-07-24" version="1">MKSYERKQLLARVERDGATIGVSIPETVDVQGEPVDLREFVMEISRRETIPAGERERVDRAKRNLRRERTERLERLEEADISKAEGEALANAIVGIDRALNALESLGPTDLESERERKEAADQKRWVSFLKQALGRDNDDARGRMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M2</accession>
    <name>R4W9M2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hel308</name>
        <name evidence="7" type="ORF">L593_08445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446528.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08445"/>
    <dbReference type="EnsemblBacteria" id="AGN01634">
        <property type="protein sequence ID" value="AGN01634"/>
        <property type="gene ID" value="L593_08445"/>
    </dbReference>
    <dbReference type="GeneID" id="16182415"/>
    <dbReference type="KEGG" id="sali:L593_08445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1730"/>
    <dbReference type="eggNOG" id="arCOG00553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_2"/>
    <dbReference type="OrthoDB" id="9752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2 3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="242"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="848" mass="90582" checksum="7BE59791879084D2" modified="2013-07-24" version="1">MDVETIPELPTGAAELLREDGIDSLYPPQAEAVEAGVTQGDNLVASVPTASGKTLIAQLAMISAIDRGGTALYIVPLRALASEKAAEFEQLEALGIDVGVSTGNYEASGEWLASKDLIVATSEKVDSLVRNGASWIENLGCVVSDEVHLIDDPERGPTLEVTLAKLRQLNPGAQIVALSATIDNADAIAEWLDAELVDTDWRPIDLRMGVHYGGAAHFDDGEEGHTREELPVGASESATGAIVRDTLEDGGSTLVFVNSRRNAEAAAGRLGSVVEPNLEPEERAKLATLAEEIRDVSDTETSDDLADAVAKGAAFHHAGLASEHRSLVEDAFRDRLVKVVSATPTLAAGVNTPSRRVVVRDWRRFDGNAGGMQPLPVLEVHQMMGRAGRPGMDPYGEALLLAKGHDELDELFDRYVEADPEPVQSKLAAEPALRTHVLATVASGFARSREELLSFLEETLYASQTSEAGRIGRVVEDVLVYLQRNDFLERDGGTLTATNLGHTVSRLYLDPMSAATIVDGIEHALVVDDGSASGDSAAERRDETSEEVPLDDAEAALNEESASGGFTPASELVDSATAGDDAADGAENDVEAATEPAEDAGPTYADDVPLTPLALYHLVSRTPDMYELYLRSGDRETYSELYYEHETELLGAAPSEYEEDRFEHWLSALKTAKLLEDWAEELDEDKITNRYGVGPGDIRSKVDTAEWLLGATEEIVAELGAPVVDDVREARMRVQHGVKDELLELVGVRGVGRKRARRLYRAGIENREALRTADKSVILGALRGREATAETILENAGREDASMEAVEPDEDAEASVEAASGSGGSGGGPDASADDDANGDQANLGDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M6</accession>
    <name>R4W9M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447692.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14295"/>
    <dbReference type="EnsemblBacteria" id="AGN02798">
        <property type="protein sequence ID" value="AGN02798"/>
        <property type="gene ID" value="L593_14295"/>
    </dbReference>
    <dbReference type="GeneID" id="16181179"/>
    <dbReference type="KEGG" id="sali:L593_14295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2926"/>
    <dbReference type="eggNOG" id="arCOG03454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072022_0_0_2"/>
    <dbReference type="OrthoDB" id="89036at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="27534" checksum="F6286512DA71BBC3" modified="2013-07-24" version="1">MTDVPSPADVFDDAVDEGNRRLEQSLLELASTSFIAGFTIVFGIVALGIVEGIVEPEFGDLAKLAGALAFGPGLVFVVVGRTELFNENFFDPTAAAVDDASGWLVRPLLRLWTLTFVFNLAGGCLIALIFAVDGALPPGAAETLTQFATETAARGAETWFARGIAGGALITLLSYLLLAVDTAGSRIALAYVVGFFLALGPFDHVVVTVLHVFFGLLFGAEIGLGRLAYMTAVVTAGNLVGGLGLVTFSHVTQIYGARDEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X1</accession>
    <name>R4W9X1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="4" type="ORF">L593_09995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446838.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09995"/>
    <dbReference type="EnsemblBacteria" id="AGN01944">
        <property type="protein sequence ID" value="AGN01944"/>
        <property type="gene ID" value="L593_09995"/>
    </dbReference>
    <dbReference type="GeneID" id="16182677"/>
    <dbReference type="KEGG" id="sali:L593_09995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2059"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OrthoDB" id="23182at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="3">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="470" mass="49108" checksum="E57490A1039D8C3C" modified="2013-07-24" version="1">MDNSAKYLIHAAFAADGIVERSDVVGAVYGQTEGLLGEELDIRRLQESSKLGRIDVEVQTASGQSAGEITIATSLDRVETATLAAALETIDRVGPCRATIEVTNLEDVRAATRRTVVDRAQELLLSEFEGATSDAIVEEVRRRVATADITTYEGLPAGPSVADGDAIVVVEGRADVKALLAAGVKNAIAVEGTDVPEIVADLSQERRTTAFLDGDRGGELILQELRQVGDVDAVAFAPADRSVEDLSRSEILAALRSTVDVAALGDAASASDLADAARARTSGGTAIETPGSDEQEPSADLETIEGEEANVAEADCTRPERAEPVGEDGDAIEAGTPADDGSAGASVDDVPEAGSERDEGSESEGSPPEDADEPRTIHDHVEAIQGTDDARFLDAEGVPLQTVAASDAFDALEAADHVPVRIVLDDALEQRLLDLAAQRGVREIVATDLGEFTKRPTDVRVRTAAALLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y8</accession>
    <name>R4W9Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446923.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10420"/>
    <dbReference type="EnsemblBacteria" id="AGN02029">
        <property type="protein sequence ID" value="AGN02029"/>
        <property type="gene ID" value="L593_10420"/>
    </dbReference>
    <dbReference type="GeneID" id="16181918"/>
    <dbReference type="KEGG" id="sali:L593_10420"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2148"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_2_2"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="27207" checksum="3C08D17DF5047E0B" modified="2013-07-24" version="1">MDSEQRRRPRVSVHEEQAVTEPVVAGFSEFGLAGLTAVDYLTTQFEMEPVGHVRADGLPSITPFTAGEPRHPVRLHASNDVPVTALVGEQFVPVWAADEFGESLLEWIDASEVDELCLVSGIPVPHGPEDHRAFWIATEDFRERRLEETDLDPMGNGFLDGVGAALLDRGIDTDLAVSVLVTPVHPQVPDADAALRLLEGLVDVYGIDVETGPLETFAEEVREYYGELSARLQTVAEDDQPEDRMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA23</accession>
    <name>R4WA23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11295"/>
    <dbReference type="EnsemblBacteria" id="AGN02204">
        <property type="protein sequence ID" value="AGN02204"/>
        <property type="gene ID" value="L593_11295"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2330"/>
    <dbReference type="eggNOG" id="arCOG00896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="138"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="48144" checksum="885470C639E769B0" modified="2013-07-24" version="1">MYDDHTVGVVIPAYNEVGFVGDVIETVPDFVDRIYPVDDCSTDGTWTEIQDTAARIDDESAAPNQASARSGDPAAAKPRSDGGVQHSETGAAPDEGVQDRVEHDVNSVERDNLQAGEADATAAVEALPDDLDFDPENDASAAAHAGFRRRVVPIRHEENRGVGGAIKTGYQRARADRIDVTVVMGGDGQMDPDWMADLIEPVVDGRAEYAKANRLILDEHHETMPRHRFVGNHTLTILTKIATGYWSVGDPQHGYTAISLEALETAGVDDMYEFFGYCNDLLIRLSAENLRVADVPCPLTYADEESHITYSTYVPRVSGMLLRSFLRRLWVDRDGASGRGRLALFVGGAVATVGGLLGIILTGLTAIAGDPESAATPAEASSQPDSQRSTNAGVCRSALLAVAGVVSLLTAMLLDAVTNATSNYTERVPEDAEPRVENPTAEPPDAADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA49</accession>
    <name>R4WA49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11955"/>
    <dbReference type="EnsemblBacteria" id="AGN02334">
        <property type="protein sequence ID" value="AGN02334"/>
        <property type="gene ID" value="L593_11955"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2460"/>
    <dbReference type="eggNOG" id="arCOG06316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="11664" checksum="856C784A58B26E35" modified="2013-07-24" version="1">MVVSFPGRVSPADAGVTMKSIELLYLAFSGTLAVAGLTMVGMAIRAYAETQRRHMVHLSIGFTLIVGAAVATTISAFINDFQNPQSLLTVNYFVTTLGFVFIVFSLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA91</accession>
    <name>R4WA91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447438.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13025"/>
    <dbReference type="EnsemblBacteria" id="AGN02544">
        <property type="protein sequence ID" value="AGN02544"/>
        <property type="gene ID" value="L593_13025"/>
    </dbReference>
    <dbReference type="GeneID" id="16180348"/>
    <dbReference type="KEGG" id="sali:L593_13025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2670"/>
    <dbReference type="eggNOG" id="arCOG00250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_2"/>
    <dbReference type="OrthoDB" id="89824at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="31118" checksum="C2599054D9FB58F1" modified="2013-07-24" version="1">MVRSLDEIDRVGVVGAGTMGAGIAQVLATAGYEVAMRDVDRDLVQNGFDSIESSLDRLADRDAIPSDDVDRIVGRVDGTTDLEDLAPCDLVIEAIVEDLEIKQETFADLDRIVDEDVVLATNTSTLSITSIAASTNRPDHVVGLHFMNPVPIMDGVEVVTGESTAPDTVDLAHELAADLDKETWESDDKPGFVTNRILIPWINEGVRAFDEGVATKEDIDRGMTLGTNVPMGPLELADHIGLDVCLHASETLHDELGDRYTPAYLLKRKVEAGHLGKKTGQGFYEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA92</accession>
    <name>R4WA92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447443.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13050"/>
    <dbReference type="EnsemblBacteria" id="AGN02549">
        <property type="protein sequence ID" value="AGN02549"/>
        <property type="gene ID" value="L593_13050"/>
    </dbReference>
    <dbReference type="GeneID" id="16180360"/>
    <dbReference type="KEGG" id="sali:L593_13050"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_3_2"/>
    <dbReference type="OrthoDB" id="101975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="164" mass="18691" checksum="C6DABEB022AD2560" modified="2013-07-24" version="1">MGDTIDVRQYRSEDADEVWDVHEAALRASPLAFVEEAAVDEDICNVESHYIESGGEFLVGERRDATEDHRAIVAIGGWLPIDDRTVEVKRMRVHPDHQRNGYARRILAELERRARAAGFETAVLETIEPLRAAQALYEDEGYTVVETTADDVTGVERYRYRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA94</accession>
    <name>R4WA94_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_13100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447453.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13100"/>
    <dbReference type="EnsemblBacteria" id="AGN02559">
        <property type="protein sequence ID" value="AGN02559"/>
        <property type="gene ID" value="L593_13100"/>
    </dbReference>
    <dbReference type="GeneID" id="16180385"/>
    <dbReference type="KEGG" id="sali:L593_13100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2685"/>
    <dbReference type="eggNOG" id="arCOG02014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_2"/>
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        <property type="reaction ID" value="UER00040"/>
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        <property type="term" value="F:anthranilate synthase activity"/>
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        <property type="term" value="P:tryptophan biosynthetic process"/>
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        <property type="entry name" value="ADC_synthase"/>
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        <property type="entry name" value="Anth_synth_I-like"/>
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        <property type="entry name" value="Anth_synth_I_N"/>
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        <property type="entry name" value="Chorismate_C"/>
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        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
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        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
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    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="10">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
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        <location>
            <begin position="242"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="531" mass="56852" checksum="20B07CDFCEA7CCB2" modified="2013-07-24" version="1">MTEATVVTDRDAFLSTAADAPTGTRVPVEVSLPVDDPFDAYRRARGGDGDGGAFLETTGGQSGWGYFGVDPIERLTVGPQARSRNAPVDGEGSSGRAPTGDDSPTLAALQALLQAEALRRGDCEIPCPCGAIGWLSYDVVRELEDLPGEAVDDRDLPRFQAAFFDRLAAWECPTTEGETTLRITACPAIGGEGDRTDADAAFDRGQERALDLVDRIEKGDPDVPTVGDAAGDATFESDCTPETYADRVRAVKEYVRAGDTFQANVSQRLSAPAAVHPVAAYDALRSVNPAPYSALLELPAADLVSASPELLLERDGDRIRTEPIAGTRPRSDDPEADAALETELTSDEKERAEHAMLVDLERNDLGKVAAYGTVEVTEYRRVDRYSEVMHLVSLVEGKLREGATLADAIAAVFPGGTITGAPKPRTMEIIDELEGTRRGPYTGSIGIFGFDGRATLNIVIRTLVRHEDRYDLRVGAGIVHDSVPQREYRETLDKGRALVNAVDRALGERASLAVNGEAIDVDALDEGGEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA4</accession>
    <name>R4WAA4_9EURY</name>
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        <submittedName>
            <fullName evidence="10">Archaeal flagella assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_13350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13350"/>
    <dbReference type="EnsemblBacteria" id="AGN02609">
        <property type="protein sequence ID" value="AGN02609"/>
        <property type="gene ID" value="L593_13350"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2731"/>
    <dbReference type="eggNOG" id="arCOG01808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017646_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="9">
        <location>
            <begin position="201"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="9">
        <location>
            <begin position="535"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="751" mass="81282" checksum="994CF4EE56F27B1C" modified="2013-07-24" version="1">MIGTATVPASVVSLVGVRPFIPLIALRPFIPLAIAGLLALPILLAIGIDRVDRVLRRISVVAFGSYVDRSERKKASRQHRLRAAQFPTTYRAYASTTILYSMVGALVGGILGLYVVWGALKILAIDQERMRALLPTALAPLSNFAGLGTLTPMELLTVMLASGLTFGLLAGLLTYVFRWWWPGHVAATRMRSIEATMPQAIAFMYALSRSGMSFTKVLSIMAAHRRIYGATAAEVDVAVRQMDLFGRDMITAIQRMGRRTPSEQFQEFAENLASVLQSGRNLAGFLDDQYDDFQEEAEAQQEQLLNLISTLAEAYVTVLVAGPLFLITILVIIGIAGANTLTPLQVFVYFLIPIGNLGFILYLDTVTARFGRGERIESLPAVATGLHDIRRATGDGSSTRGPTAGELGAGGAGTGTSTAAGGRDARTDGGYAGDADRQRANLERLAVHRRIEWLRDRIGAPGRTVVQRPITLLYVTVPIAVFGTLFRLATAGQLTVDVVDDMFIQATLFVVATFAMVFEIHRRRIETIEAAVPDFLDRLASVNEAGLSMIDSIGRVRASDLGALGPEVDRIWADIQWGSDIERALKRFERRVRTRTISRVVALITNAMNASGDVSRVLRIAAAQAKADRRLKRQRKQEMLAYVVVVYVSFGVFLVIIAALDAVLIPNLPEQAITPGGGNPNQPSVTPGMGQLEGLGTIDAEAYTLLFFHTALLQALLSGIVAGQMSSGDIRDGAKHAAILMSVAYMAFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB9</accession>
    <name>R4WAB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447578.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13725"/>
    <dbReference type="EnsemblBacteria" id="AGN02684">
        <property type="protein sequence ID" value="AGN02684"/>
        <property type="gene ID" value="L593_13725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181895"/>
    <dbReference type="KEGG" id="sali:L593_13725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2807"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OrthoDB" id="106121at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10536" checksum="F2259EFFE2C30027" modified="2013-07-24" version="1">MEGVLWYVLASSRGGPTRTQLVRAIDEQPRNANQLAETLEYDYTTIRHHLDVLMDNNVVRRAGDGYGDVYLLTEQVKANRETLEEVLDTVDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT01</accession>
    <name>R4VT01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445214.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01845"/>
    <dbReference type="EnsemblBacteria" id="AGN00320">
        <property type="protein sequence ID" value="AGN00320"/>
        <property type="gene ID" value="L593_01845"/>
    </dbReference>
    <dbReference type="GeneID" id="16179968"/>
    <dbReference type="KEGG" id="sali:L593_01845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.373"/>
    <dbReference type="eggNOG" id="arCOG00381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048695_1_0_2"/>
    <dbReference type="OrthoDB" id="50724at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="42035" checksum="E8DAD9114318ED13" modified="2013-07-24" version="1">MRTTAAALTCFLLVAALTGAAAVSGTPSTQAPGASDATADLVDTQPAQQFNGSSPETITITIQNDGDARFVLSKTFPAGTESERAAFERLAQDFQSGQYGRLGYGTFESIVDDVAAETGREMTLTDAGPATTVDGDVGRLEYRFTWTNFAQVNSDNVTVGDAFRTGEGLWLDGLGDGDRLVIEAPDGYTVAESPSGPEIVDDSLIWRGPATFGPGDLEATFEESQGGSAFPMTALLAVLGIVLAGLLAVVGWRIADRQSDETSIGDRIGTLVAASSSTSDDERDDVPDAEGGTSTGGSAASEGTAVPADVAAASAADEAPSADTANGEETVDPELLSDGERVEHLLEANGGRMKQANIVTETGWSNAKVSQLLSRLDEEDRVDKLRIGRENLITLPDVDVTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTR0</accession>
    <name>R4VTR0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leuS</name>
        <name evidence="15" type="ORF">L593_03345</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445514.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03345"/>
    <dbReference type="EnsemblBacteria" id="AGN00620">
        <property type="protein sequence ID" value="AGN00620"/>
        <property type="gene ID" value="L593_03345"/>
    </dbReference>
    <dbReference type="GeneID" id="16182074"/>
    <dbReference type="KEGG" id="sali:L593_03345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.678"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_2"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="272"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="459"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="695"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN00620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="925" mass="103291" checksum="16C4D9A3097A89B3" modified="2013-07-24" version="1">MRRHYDHARVQEYWQHVWEREDVYRCPDSAEDPTYVLGMFPYTSGSLHMGHVRNYAITDAYARFRRMQGDTVLHPMGWDAFGLPAENAAHERLTDPESWTRSCIERMRDDMEELGFGYDWEREITTCDPSYYRWNQWLFTRFYEEGLVDYRDATVNWCPDCETVLADAQVETADEQGFPDAGSDPLEDPLDPAAARAETGDASDAEPEADDAGAHDHDADDDAGVCWRCGTPVVTRDLEQWFLRTTEYAEELDDGLDELDAWPEGVRNIQADWIGRQEGAEVTFDVPAFGDLAVFSARLDTVHGATYVAVSPGHDLARQRADEDDAFAADLESLRQADHAEDTAGVDTGLTAIHPLTGDELPIYAAPYVLEDVGTGALMGVPAHDERDHAFASDHGLPIEPVVAESADAPITDADQLPFTEDGVLTDAAGEYAGLESAEARERLLADLDAAAESTTYRLRDWLISRQRYWGTPIPIVHCAECGRVPVPDEDLPVELPEFEHTTGNPLDAAEDWKQTECPECGGPAERETDTMDTFVDSSWYFMRYLSPDLDSAPFDADLAEEWLPVDVYVGGEEHAVLHLLYIRFFARALADIGLATHREPVQRLVNQGTVLHSGRQMSEASDNVVAPHEYGPETTRLFILSAAHPERDFEWTARNVGAAYDLQQDVHGMVVDFLQRTEVRRDREPRDDHLDRAVDRAIDAVADHYESFRFHRAVTEIRELASLCNRYSAYGLPHDDGYERALQAIAALIAPLTPYLGEELWNLLRADGLVVEADWPEPETDVPTEDRAAERRLVDDVLADVREIVDVVDIDDPEHVELVVAQDWKYRAYEIAQEAGRDEPIVGNIRADEGVPDTDAAAAFAGDLASEGQGLEPVVDGERALELLADAAWLLDDEFGAEVTVRRAEDGEDLAAKAAPRKPAIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUQ5</accession>
    <name>R4VUQ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">fumC</name>
        <name evidence="6" type="ORF">L593_00205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444890.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00205"/>
    <dbReference type="EnsemblBacteria" id="AGM99995">
        <property type="protein sequence ID" value="AGM99995"/>
        <property type="gene ID" value="L593_00205"/>
    </dbReference>
    <dbReference type="GeneID" id="16181024"/>
    <dbReference type="KEGG" id="sali:L593_00205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.41"/>
    <dbReference type="eggNOG" id="arCOG01749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_2"/>
    <dbReference type="OrthoDB" id="26165at2157"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="13"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGM99995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="468" mass="50265" checksum="E433B9B9B6E886E9" modified="2013-07-24" version="1">MTEEYRTERDSLGEMQVPADAYWGAQTQRAVENFPISDRRFGRRFVRALGVVKKAAARANLDLGTIPQEKGEAIVAAADEVIAGELDDQFPVDVFQTGSGTSTNMNANEVIANRATEIVGGEIGSREVHPNDHVNFGQSSNDVIPTAMHVAALEAVEKDLRPGLVTLRDVLAEKEQAFDGVVKTGRTHLQDATPVRLGQEFGGYRTQVEKGLRRIDHVGDHLAELALGGTAVGTGLNTHEEFPQRAAEYIAEETELPFREADDHFEAQAAHDAMAEAHGALRTIAGSLNKMANDLRLLASGPRNGLGEVEQPENQPGSSIMPGKINPVVAESVNQVHKQVVGNDAAVSAGAARGELDLNLYKPVLASNFLESTQLLANASENFAAKFVAKLEANEAHCEAQVAQSMALATALNPHIGYDKASKAAKQALAEDKTVREVVIDEGYLSEEEADEVLDPESMTYTGILGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUR8</accession>
    <name>R4VUR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445869.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05130"/>
    <dbReference type="EnsemblBacteria" id="AGN00975">
        <property type="protein sequence ID" value="AGN00975"/>
        <property type="gene ID" value="L593_05130"/>
    </dbReference>
    <dbReference type="GeneID" id="16181235"/>
    <dbReference type="KEGG" id="sali:L593_05130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1046"/>
    <dbReference type="eggNOG" id="arCOG09205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116128_0_0_2"/>
    <dbReference type="OrthoDB" id="114768at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22394" checksum="869F64F25F7FCCA5" modified="2013-07-24" version="1">MHQRLRAGAAVYNAGEYHAAHDAWEERWLDLQDGTDDERLLHGLIQYTAAVHHATNRNWAGAVGLAESALDYLAELPADYRGVDLVRAREYLDLLAADPERIERAPAWPLAIDGAVISVGELSATELGIAAATVAEDDELDESVCERAAERVADGTTENEGRLKALLEDFVTSAESRGIVHQRLRGHVEREEARDRDVEGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUS3</accession>
    <name>R4VUS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445874.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05155"/>
    <dbReference type="EnsemblBacteria" id="AGN00980">
        <property type="protein sequence ID" value="AGN00980"/>
        <property type="gene ID" value="L593_05155"/>
    </dbReference>
    <dbReference type="GeneID" id="16181243"/>
    <dbReference type="KEGG" id="sali:L593_05155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1052"/>
    <dbReference type="eggNOG" id="arCOG00287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054695_0_0_2"/>
    <dbReference type="OrthoDB" id="21757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="75"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="436" mass="49239" checksum="CEDE800C18E9761C" modified="2013-07-24" version="1">MTLDRVHFRGIARHARRISRGIDEREHQRFAETVWKEFLDPLRDDDGRAVLRPLDDQELREIDLEVAALRDPVFETAHGLDSGTINPTSYKNGLVLDVAQAAMAAEPSDLDLHRQRSLITTVHSGDLASVEEIEERLDEGNTHSQLLRAPQVPRFEESVVHELSLYLAESQHALAHFDAVEDLLVLDGPIYPKGMLNWADRAPELRDLLYDEPEPRDVIENYVHLVERAVDREVPVIGFVKNPATKAITRTLRERGEQAPWVGDTALFTRLLERGEFVETVDEHGETHRERRRDTDALTYTSWFRSRGGADRLLAGNGDPGTGTTDPGAFGIDRELDPEAYEVTFFALYDPRDDLLYRIEAPLALTEDEDCRSALTDFVLREVAAERGPPTAVAKADSLARIGQRSTNDLRDALAEAFGTDRMRDYDDRRWGGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUT0</accession>
    <name>R4VUT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444915.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00330"/>
    <dbReference type="EnsemblBacteria" id="AGN00021">
        <property type="protein sequence ID" value="AGN00021"/>
        <property type="gene ID" value="L593_00330"/>
    </dbReference>
    <dbReference type="GeneID" id="16182054"/>
    <dbReference type="KEGG" id="sali:L593_00330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.66"/>
    <dbReference type="eggNOG" id="arCOG03101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057821_0_0_2"/>
    <dbReference type="OrthoDB" id="36265at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="153"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="34139" checksum="0840B5FE5599493B" modified="2013-07-24" version="1">MPSNIPGVHHVTAIAGDPSRNLAFYTETLGLRLVKRSVNQDDVGTYHLFYGDHGGSPGTSMTFFPHPNARRGQVGNGQVSTTQFLIPGDAVEYWTERLADEGVDAREPHDRFGDTVIAFEDPDGLPLELVARDDAPAGDPPDGPVPADYAIRGFFGVTLSLARARGTTNLLEAMGFEATESTANRERYESHGDLGYVVDVLEDDSIPAGSQGAGTVHHVAFQVTAEEQAEWREVLQSHGLRPTEIIDRKWFESVYARTAGGVLFEFATEEPGYTVDETLDSLGESLVLPEWLEERRDEIAAQLPPLDGSSRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV13</accession>
    <name>R4VV13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopropylmalate/homocitrate/citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00805"/>
    <dbReference type="EnsemblBacteria" id="AGN00116">
        <property type="protein sequence ID" value="AGN00116"/>
        <property type="gene ID" value="L593_00805"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.165"/>
    <dbReference type="eggNOG" id="arCOG02092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="36974" checksum="61E7480CF026D55D" modified="2013-07-24" version="1">MGTHVIEAGFPVNSDAEFEAVRDIAKSTSSDVCGLARVVDKDIEAALDSGAEMVHVFVSTSDVQIEDSMHATREEVRQNAVDAVERVTEAGATCMFSPMDATRTDEGFLLDVIEAVSEAGTDWINIPDTCGVAAPRRFYDLIDTVTDHTDARIDVHTHDDFGMATANAIAGIEAGADQAQVSVNSIGERAGNAAYEEFVMAVESVFQADTGIDTTRITELSRVVEEKSGIETPGNKPVVGANAFSHESGIHAAGVIENSDTFEPGVMTPEMVGAQRELVLGKHTGTHGVRERLVDAGFAPSDEEVRAVTRRVKDYGAEGDRVTEAELERFAREVGVSLEEEEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV37</accession>
    <name>R4VV37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445030.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00905"/>
    <dbReference type="EnsemblBacteria" id="AGN00136">
        <property type="protein sequence ID" value="AGN00136"/>
        <property type="gene ID" value="L593_00905"/>
    </dbReference>
    <dbReference type="GeneID" id="16182226"/>
    <dbReference type="KEGG" id="sali:L593_00905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.186"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126371_0_0_2"/>
    <dbReference type="OrthoDB" id="107319at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="189" mass="20327" checksum="17717C1D0CD76537" modified="2013-07-24" version="1">MAIDLEGFASDLAETTADQLATWIETSVPTLLQALIVLGLAYVGIKILLTVLRRVLGSVYGKREDLVVDLLVTIVAIFLWFGVALSVLSTLGMGEIAASLGTATGFIALGVSYALSDMIEDTVAGVYLLRDPDFEVGDRVVTDKGEGVVEAIELRKCRLMQDDGDVLVVANGDVEKKWKRLGDRQPPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV81</accession>
    <name>R4VV81_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="9" type="ORF">L593_01115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445070.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01115"/>
    <dbReference type="EnsemblBacteria" id="AGN00176">
        <property type="protein sequence ID" value="AGN00176"/>
        <property type="gene ID" value="L593_01115"/>
    </dbReference>
    <dbReference type="GeneID" id="16182487"/>
    <dbReference type="KEGG" id="sali:L593_01115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.228"/>
    <dbReference type="eggNOG" id="arCOG04125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="7">
        <location>
            <begin position="9"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="8">
        <location>
            <begin position="178"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="283"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="350" mass="35518" checksum="25FD0669A227AF77" modified="2013-07-24" version="1">MIRIDGADAGGQLLRSTLALSALTQEAVRIEQVRGARSTPGVRPQHLAAIEALASVTDAVVDGAEVGADVVTFDPDPVSGGQLSIDVGTAGSASLVVDALLPLAAALDEHLAVRVGGGTDVKWSPPLDAHLLAKLPLLRSHGWGVALECHRRGFYPEGDGDVTLHLFPSTPAPFRLAERGPIERTTIRSVATDDLADGDVARRQVTAASSRLAEAGYEVDSTIVESVSAPSTGTAIVAVSAFDCGVCCGDALGKQGRPAEVVGEGAAESLLDAIDGPGAVDAHLGDQLLLPLVVAGGKLRIPERTDHVETSLALLASFGLAPAAHSDGPGGPLLEADSGAVADRLGNGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVJ6</accession>
    <name>R4VVJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Halocyanin hcpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445165.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01590"/>
    <dbReference type="EnsemblBacteria" id="AGN00271">
        <property type="protein sequence ID" value="AGN00271"/>
        <property type="gene ID" value="L593_01590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180653"/>
    <dbReference type="KEGG" id="sali:L593_01590"/>
    <dbReference type="eggNOG" id="arCOG02918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_3_2"/>
    <dbReference type="OrthoDB" id="115753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Copper-bind" evidence="6">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="15491" checksum="D5F2E43292AA2F57" modified="2013-07-24" version="1">MPESYSRRQFVAGTSAVTIAALAGCSGGGGGDGDSDDGDGSSDGGGGGDNIVAVGPGGDLVFEPDEITISTGETVTWEFESPTHNVSAYPDMSEEISIPDGASGFGTMEEGGDAYETVSEGETFEHTFETAGEYTYVCVPHVASGMIGTIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVR2</accession>
    <name>R4VVR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446184.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06715"/>
    <dbReference type="EnsemblBacteria" id="AGN01290">
        <property type="protein sequence ID" value="AGN01290"/>
        <property type="gene ID" value="L593_06715"/>
    </dbReference>
    <dbReference type="GeneID" id="16181438"/>
    <dbReference type="KEGG" id="sali:L593_06715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1371"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_2_1_2"/>
    <dbReference type="OrthoDB" id="12601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="37361" checksum="FA1FC8B2002DDC55" modified="2013-07-24" version="1">MTEDDVALTGYGVYVPDDVVTGEAIAAESGIPEAVVVEKMGLREKRVCPPGEDHASDMCVNAGELALADSGIDASDLDLVLYHGSEYKDFVVWSAAADVADRLGAENAYATESYTLCAGAPIAFRQVRAQLLAGPIDAALLVSASREEDLVDYTNERSSFMFNFGSGASAAVLEADPGAGDDDGAAPSVADRARATVQESAAITDGSFSRDVVMPAGGSVEPPSHSSVDAGLHSLDVPDQEGMKERLAPVSLPNYLEVADEALERSGFDRSDLDFVAVTHMKRSFHETLLEELGVDHETDGYYLDEYGHVQSVDQLLAVGEAVDDGRLEAGDVVLFLAAGTGYTWAATVLTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW12</accession>
    <name>R4VW12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445350.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02525"/>
    <dbReference type="EnsemblBacteria" id="AGN00456">
        <property type="protein sequence ID" value="AGN00456"/>
        <property type="gene ID" value="L593_02525"/>
    </dbReference>
    <dbReference type="GeneID" id="16180249"/>
    <dbReference type="KEGG" id="sali:L593_02525"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_2"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="29616" checksum="55EE38B526DCB8C4" modified="2013-07-24" version="1">MARVLVAGHVNLDVTLLVDRLPAADEEAAIQERVRSGGGSAANVATGLARLGVDARLLGSVGDDEPGRRVRERLGEHGVDVDPVVEAPGETSTKYLLVADEDVAMLGNDGVNEAVAPADLAPGTVADVEHVHLTGQRADTAERLARLAVDAGCSVSLDPGRRAGDRALDGVADRADVVFGTDREIAALYGDDPTAAAGSERLVVATSGAGGARCFLGDETRAHPGFDVDVADTSGAGDAFVAGFLSIWLAADDLDEALAFGNACGAIASQRVGARTALDPDAVASFRDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWE5</accession>
    <name>R4VWE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446454.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08075"/>
    <dbReference type="EnsemblBacteria" id="AGN01560">
        <property type="protein sequence ID" value="AGN01560"/>
        <property type="gene ID" value="L593_08075"/>
    </dbReference>
    <dbReference type="GeneID" id="16182300"/>
    <dbReference type="KEGG" id="sali:L593_08075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1655"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="109"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="34340" checksum="ED2980B2BE52B273" modified="2013-07-24" version="1">MPTVVHSDTEIIDAELLERELGDRAAIEARHTRTEAAVADALADAAVLVLDDKSPVTADVLADAEDVALIARAGTGVDTVDLEAAAEHGIPVTNVPAYGTEAVATHAIGLLTSVWQAIPRRDRAIRDGDWDWEVGRPVPRLPEATLGIVGFGRIGRRTAAYASGLDLDVLAYDPYVDADEIESHGGEKVDDLHHLAADADVLSLHAPLTAETEGMIDADVFATLPEHAVLVNTARGDIVDQDALREALDAGELRAAALDVLEEEPPGEEPLLDRDDVVTTAHAAWYSEASRRDLNETVARQVLAALDGEDPEHLVDPDAAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWS5</accession>
    <name>R4VWS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-D-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446584.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08725"/>
    <dbReference type="EnsemblBacteria" id="AGN01690">
        <property type="protein sequence ID" value="AGN01690"/>
        <property type="gene ID" value="L593_08725"/>
    </dbReference>
    <dbReference type="GeneID" id="16182521"/>
    <dbReference type="KEGG" id="sali:L593_08725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1788"/>
    <dbReference type="eggNOG" id="arCOG01757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_2"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="56"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33549" checksum="63E3B60ECBE5555C" modified="2013-07-24" version="1">MKLGIHESVEAVFPPAELQTALTEAGVEAELVGDDPIELGACDGVVTFAHREYFFDAVEWVHSIQAGVDRFPQNEFEAEGLTLTNSTGIHGASVGETVLGYMTAFARNLHAYRSAQDRGEWIEPDWDRPFTLEDESVCVVGLGTIGQAVAERATWLGMDVWGVRRSPDPVPIVDEVYGQEDLHTALLDATFVVLAVPLTPATRRLIGPAELAAMDDDAYLINVARGSVVVQDALVSALENDDLAGAALDVFQEEPLPADSPLWELDEVIVTPHSAARTRDYFRDIAEIVLDNVERLEEGRTLRNQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX04</accession>
    <name>R4VX04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446639.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01745">
        <property type="protein sequence ID" value="AGN01745"/>
        <property type="gene ID" value="L593_09000"/>
    </dbReference>
    <dbReference type="GeneID" id="16182713"/>
    <dbReference type="KEGG" id="sali:L593_09000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1846"/>
    <dbReference type="eggNOG" id="arCOG06388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134823_0_0_2"/>
    <dbReference type="OrthoDB" id="94817at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="16745" checksum="07F83FB5C95139E9" modified="2013-07-24" version="1">MSYLVPFDDSPLSRTALRRAGEFGRVMDERVVALVVVPPSTDYAREKGWIDPGEPYDADRIERGLRAAAREIAPDAEVRVETTEETDYRASMTTDVVRRIRQVAGDLEASVLFIGTANAGSVVTPVASVGSPVSDDPQYDVHLVRHADEDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX25</accession>
    <name>R4VX25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor IF-2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445710.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04325"/>
    <dbReference type="EnsemblBacteria" id="AGN00816">
        <property type="protein sequence ID" value="AGN00816"/>
        <property type="gene ID" value="L593_04325"/>
    </dbReference>
    <dbReference type="GeneID" id="16180906"/>
    <dbReference type="KEGG" id="sali:L593_04325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.880"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_0_2"/>
    <dbReference type="OrthoDB" id="73843at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="4">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="22142" checksum="710C680FAE7EEC81" modified="2013-07-24" version="1">MDYETSLDRAYDDLPELGTEEDRLDVPEAALETDGAFVRFTNIERVADALDRDADHLHRYVQSELGTAGTFEGGQARYSGSFTRADFENAIDAYIAEFVTCSECGLPDTKLVKENRTQMLRCTACGAFRPISKRSTATSQQQQEAVEEGGTYEVEITGTGRKGDGVANRGKYTIFVSGAREGETVQAYVESTSGDLAFARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX91</accession>
    <name>R4VX91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CinA N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09525"/>
    <dbReference type="EnsemblBacteria" id="AGN01850">
        <property type="protein sequence ID" value="AGN01850"/>
        <property type="gene ID" value="L593_09525"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1961"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="24285" checksum="72E29F72F452A59D" modified="2013-07-24" version="1">MVTVGDELLAGDTANTNATWLCTELTDRGVSVRRVITLPDVVGEIARVVNEYRAEYDAVVITGGLGPTHDDLTMEAVAAAFGQEVEHSQAAEDWLVEHGGYSADDLDPGTTGIPAGAEPLHNEVGVAPGCVIGDVYVLPGVPAEMKAMFADVADNFSGPERFVVQVPVDEPESHLVERFAELRETFDVDVGSYPGEHVRVKLSGTDREQVAAAEAWLRERVDLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX97</accession>
    <name>R4VX97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445780.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04685"/>
    <dbReference type="EnsemblBacteria" id="AGN00886">
        <property type="protein sequence ID" value="AGN00886"/>
        <property type="gene ID" value="L593_04685"/>
    </dbReference>
    <dbReference type="GeneID" id="16180985"/>
    <dbReference type="KEGG" id="sali:L593_04685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.957"/>
    <dbReference type="eggNOG" id="arCOG02304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_2"/>
    <dbReference type="OrthoDB" id="20007at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="399" mass="42910" checksum="62C7D66877161FAB" modified="2013-07-24" version="1">MSALSDLRVLDLTQVLAGPYCTMLLADMGADVVKVERPGGDLIRRNPPFAEDPEAEAYGGYFQSVNRGKRSLELDLGDEDDRGDFLHLVETADVVVENYRAGTMEKFDLGYETLRERNPQLIYSSIRGFGDPRTGESPRQGQPSFDLIAQALGGVMSITGQPDGPPTKVGPGIGDLFTAVLNCAGILAAVHHRERTGEGQHVDTGMYDAMISMCERAIYQHSYTGEIPGRRGNSHPTLFPYDAFETADGHVVIAAFGDGHWTALCRAMEQPDLAAEYDSGAARLANREALRAAIAEWTAERHTAAIVDLLEGDVPAAPVQDTADIFADEHVHAREMLVEVDQPGADRSVTIAGSPIKLSATMPEPGGRAPLLDEHRDELLGELAERTDAATSGATAGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXV1</accession>
    <name>R4VXV1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcvT</name>
        <name evidence="9" type="ORF">L593_05735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445990.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05735"/>
    <dbReference type="EnsemblBacteria" id="AGN01096">
        <property type="protein sequence ID" value="AGN01096"/>
        <property type="gene ID" value="L593_05735"/>
    </dbReference>
    <dbReference type="GeneID" id="16181482"/>
    <dbReference type="KEGG" id="sali:L593_05735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1174"/>
    <dbReference type="eggNOG" id="arCOG00756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_2"/>
    <dbReference type="OrthoDB" id="25548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="8">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="39630" checksum="D046357584EC8FA8" modified="2013-07-24" version="1">MAERTPPLHDEHRAADADFTDFGGWSMPVEFDGIRTEHEAVRESVGRFDVSHMGQVVVSGPGATELMDRLTTNDVEALSVGDAQYAAITDERGVMLDDTVVYRLPDRQAQPAYRFVPNAGHDEQMAERWRSHRDRWGLAAEVDDRTGEDAMLAIQGPEAMAAMAEIGEDVSDLGRFEARWADVAGVECWVARTGYTGEDGVELICPAGVVDTVWNELDCQRCGLGARDTLRLEAGLLLSGQDFDAEDNPRTPYEADLGFVVEFDSDFVGLDALAEQAEEGVAERIVGFELEERGVPRHGYSIESADGETIGEVTSGTMSPTLDEAIGLGYVPIDYTEPGTDLRIVVRDDPKVATVRELPFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXW8</accession>
    <name>R4VXW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05810"/>
    <dbReference type="EnsemblBacteria" id="AGN01111">
        <property type="protein sequence ID" value="AGN01111"/>
        <property type="gene ID" value="L593_05810"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1190"/>
    <dbReference type="eggNOG" id="arCOG03113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="12629" checksum="2CE6E8E8DCF75573" modified="2013-07-24" version="1">MVHEPADGSPRPLATDVDTADWLLPKAIGLMGRSSIPEDYAMIFDFGTPTTRSVHMLFVRTPIDVVWTENDRVERVETLAPWTGHARARSDRFIELAPGAASDVEPGDRVVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY25</accession>
    <name>R4VY25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447059.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11100"/>
    <dbReference type="EnsemblBacteria" id="AGN02165">
        <property type="protein sequence ID" value="AGN02165"/>
        <property type="gene ID" value="L593_11100"/>
    </dbReference>
    <dbReference type="GeneID" id="16180759"/>
    <dbReference type="KEGG" id="sali:L593_11100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2290"/>
    <dbReference type="eggNOG" id="arCOG04069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OrthoDB" id="58391at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="31653" checksum="4124F1B5CA54E226" modified="2013-07-24" version="1">MHVSVLVPSSLAREAEDKREATRKLGYVARAATIYRVDRLVVFDDPAGETGSMDGGFVRTVLRYAATPPYLRKEAWGERDELEYAGVLPPLHASSRTGSGSSGPGSLRQGIVTEVGPDGRVRVNCGVQHPISLPVPHERDIGEGERVTVRVSSRRPVRAKIVDEPLPGFEVDRADLPTAIEDSRNTCRIAASRHGTPLTATRLTDLVGHLQTEGLTLALGAPERGLPEILDVDADSVDDSPSALRRAIESSGDADVDPTPGGFDCWLNTIPNQGSETVRTEEALFASLATCTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY30</accession>
    <name>R4VY30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rps19p</name>
        <name evidence="8" type="ORF">L593_11125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447064.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11125"/>
    <dbReference type="EnsemblBacteria" id="AGN02170">
        <property type="protein sequence ID" value="AGN02170"/>
        <property type="gene ID" value="L593_11125"/>
    </dbReference>
    <dbReference type="GeneID" id="16181377"/>
    <dbReference type="KEGG" id="sali:L593_11125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2295"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OrthoDB" id="99236at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15987" checksum="16F8D28BD683D5B2" modified="2013-07-24" version="1">MSESGYRTGHEGEFTFRGHTLDELQDMSVEDVAELLPARQRRSIERGLSPEKQKLLEDAREAEPEETAQSPLRTHLRDMPILPEMVNLTFAVHDGQDFERVDVEPEMLGHYLGEFQQTRGKVEHGQAGIGATRSSKFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYE2</accession>
    <name>R4VYE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP-endonuclease/AP-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446135.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06470"/>
    <dbReference type="EnsemblBacteria" id="AGN01241">
        <property type="protein sequence ID" value="AGN01241"/>
        <property type="gene ID" value="L593_06470"/>
    </dbReference>
    <dbReference type="GeneID" id="16180745"/>
    <dbReference type="KEGG" id="sali:L593_06470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1319"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_2"/>
    <dbReference type="OrthoDB" id="28306at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="36242" checksum="EB8CACC4F5A133EC" modified="2013-07-24" version="1">MQVGVLTVPLGGQSLDEALEYLTGLGVEMVELGCGGDPGDDHLPMDEYLDDEEAQAELQALLDEHGVGISALATHNNPLHPDEERAEAADEQLRNAIRLADQLDANTITCFSGLPAGGPNDEVPNWVTAPWPNEHLDALEYQWEEVAIPYWQDMAEFADDHGVDVAIEMHPNFLVYNPPSMLKLREATNERIGTNLDPANIVWQGIDVPEAIRYLGEEDAIHHVHAKDLRTYESNKDVTGALDTKPYTEEIDRSWIFRSIGYGHDMDYWKDLVSTLRMVGYDGTLSVEHEDSLTSAREGLEKAIGTLDEAIFETQPGEAYWVDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYG9</accession>
    <name>R4VYG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446165.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06620"/>
    <dbReference type="EnsemblBacteria" id="AGN01271">
        <property type="protein sequence ID" value="AGN01271"/>
        <property type="gene ID" value="L593_06620"/>
    </dbReference>
    <dbReference type="GeneID" id="16180850"/>
    <dbReference type="KEGG" id="sali:L593_06620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1350"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063607_0_0_2"/>
    <dbReference type="OrthoDB" id="80752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="35346" checksum="65BE2DAA73635D5D" modified="2013-07-24" version="1">MADVDTLDDADNIELTDEDLESESKGELIKRAGQLRDRRNELNQMASERAGKRDDLNAATREKVDEAQEHRERRDELNELVQSHKEQRNELNAKANELFDKVDDEKEDLELEDGKSLDQLEEEIEDLEFKQQTEVLSSEDERELIEQIEEKREEYQARKEKLENSGDLEELKERAEQVRSEASKHHRKVTTLADEAQEHHNEMIEAYREADDIRDEADEMHELFVEAQEAADRHHEDFVRVQKRLRELDKEEEEERKTERQEKKEDAKEEAEEIYQKFKDGETLDTEDLMKLQKTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYQ7</accession>
    <name>R4VYQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447289.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12270"/>
    <dbReference type="EnsemblBacteria" id="AGN02395">
        <property type="protein sequence ID" value="AGN02395"/>
        <property type="gene ID" value="L593_12270"/>
    </dbReference>
    <dbReference type="GeneID" id="16179835"/>
    <dbReference type="KEGG" id="sali:L593_12270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2524"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="415"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="557" mass="58344" checksum="C0B90D49D3C8CF77" modified="2013-07-24" version="1">MVRTTDAIAAIFEQAGIETVFGFPCEQMDPYYASLAASDLRHILARSEASAALMADGYARAARTVGVVDGVSGPGAAYMGVGLCEASGASSPVLALTGGNDRTTRGNGVIQDGDNEAILEPFVGTTADAETPERAVEHVEQALRAATTGVPEPAHVNLPEDVMAEETDRNPRGDVAADYPRTRPEPDDEAVADVVELLADAERPVVVAGEGVLRAGASDALADFAETANVSVVTSMNGKGAVAETAPYALGVVGRWGFCQVANDAVEDADLVLGLGTRFGELTSVGWTLVPEDVPVVHVDLDPEWLGRNYEPMVGIRADLRATLTALTAAAEGAATSATDEDADRTDRIDDLAEDRRAWREEHADDLTSDATPIKPQRVVGELNERLPADAVLVSATSFPGFFSGAFYETERPGLGYLQARGSDGINVCLPQALGVQAALPDRPVVALSGDGGIGYHISDLETAAREELPITVVVTNNESLGSSKMSQLGTYNVDQSTDFHAGVDYAQVARGFGCAGERITDPDRVGPAIEESLDADVPTLLDVQVDPYAAPPVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZE5</accession>
    <name>R4VZE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_13530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447539.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13530"/>
    <dbReference type="EnsemblBacteria" id="AGN02645">
        <property type="protein sequence ID" value="AGN02645"/>
        <property type="gene ID" value="L593_13530"/>
    </dbReference>
    <dbReference type="GeneID" id="16180704"/>
    <dbReference type="KEGG" id="sali:L593_13530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2770"/>
    <dbReference type="eggNOG" id="arCOG01762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_3_2"/>
    <dbReference type="OrthoDB" id="14180at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="8">
        <location>
            <begin position="177"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="10">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="522" mass="59119" checksum="40B719490FEB5137" modified="2013-07-24" version="1">MDRQDRRAISREYFSQERLAEHHFRSFNDFLDRGMQQVVDEKETIDTDIGDKEGEEPVHVELGEVRVVTPRVREADGSEELLYPQEARLRNITYSAPVFMEMAIVKGDPEQGEDRVVDQTETKIGRMPIMVGSNKCNIAGFSDEELIEIGEDPADPGGYFCVNGSERVLMTSEDLAPNKILAEYDTKYGDEIQVAKTFSQRRGYRALVLVERNREGLLEVSFPSVSGSIDFVTLVRALGLESDEEIVHRVSDDPDIVKFMLENLEAADVQTEEGAIETLGERVASGQGKNYQLKRANYVIDRYLLPHLHEEGVDEEEVRINKAFYLCRMAEACFELALDRRESDDKDHYANKRLKVSGDLMTDLFRTALNKLARDVKYQLERANMRNRNLSVSTVVRSDVLTERLEHPLATGNWVGGRSGVSQLVDRTDHMGVLSHLRRLRSPLSRSQPHFEARDLHATQWGRVCPSETPEGPNCGLVKNFAQAMELSQDIEDDRELKRELASMGVEGIPGIEGVDRRAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZG7</accession>
    <name>R4VZG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446540.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08505"/>
    <dbReference type="EnsemblBacteria" id="AGN01646">
        <property type="protein sequence ID" value="AGN01646"/>
        <property type="gene ID" value="L593_08505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182437"/>
    <dbReference type="KEGG" id="sali:L593_08505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1741"/>
    <dbReference type="eggNOG" id="arCOG04737">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063980_0_0_2"/>
    <dbReference type="OrthoDB" id="55211at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="31277" checksum="0D6258237CCD4159" modified="2013-07-24" version="1">MFSERALSAPVAAVRERHAPDAQILDTEQDFETLDPAVAEDLGLLVDRLEPHRYPAAWLPPDSPALLEQYASSDFTIGAPGDGSVVWTRQTEPPTILVKPRIEGSPESFVDFLLAHALVQLGLDVSVPGVEDGGASGDGAVETGGPGSPPSTSPPPEHFLGFFREHYPALADATPLDPAGTYQLAAALYDAWLGLHTRDVFAEWVGADDEDLSKLGDAWQDAGDRLEGRLDGLPGEVARGETDFPDAAELACAAVKHALELPAPYAALDTEAYRNRGAPFAVKWAEKTFDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZJ0</accession>
    <name>R4VZJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_13730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447579.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13730"/>
    <dbReference type="EnsemblBacteria" id="AGN02685">
        <property type="protein sequence ID" value="AGN02685"/>
        <property type="gene ID" value="L593_13730"/>
    </dbReference>
    <dbReference type="GeneID" id="16182021"/>
    <dbReference type="KEGG" id="sali:L593_13730"/>
    <dbReference type="eggNOG" id="arCOG02228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_6_1_2"/>
    <dbReference type="OrthoDB" id="114233at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15542" checksum="623CE9C95592003E" modified="2013-07-24" version="1">MVDLRTAFADAIQFTRIWQFVAVGAVGTACDFAVLIGLVELFDVWPVAAKIVSAETAIVVMFAINETWTFASWGVDTFRGILRRLLTSNLVRLGGMAVATVVLAILTTQYGVSYILANAAGIAAGFTVNYMMENLFTWRTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZS1</accession>
    <name>R4VZS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="8">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpE</name>
        <name evidence="12" type="ORF">L593_08830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08830"/>
    <dbReference type="EnsemblBacteria" id="AGN01711">
        <property type="protein sequence ID" value="AGN01711"/>
        <property type="gene ID" value="L593_08830"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1809"/>
    <dbReference type="eggNOG" id="arCOG02014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_0_2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010116">
        <property type="entry name" value="Anthranilate_synth_I_arc_typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01820">
        <property type="entry name" value="TrpE-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="11">
        <location>
            <begin position="43"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="10">
        <location>
            <begin position="262"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="555"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="650" mass="68705" checksum="A36DE6E2ABC92D65" modified="2013-07-24" version="1">MTLSMDRETFVAHAGDVQGAEDDVDTGDPAVIRVATEIESEITPLSAYAALTGRTTDADAADHAFLLESGGKTAASDPDGAFRPSHATTDRHARYSFVGYDPEAVVTVGDDGAEVDVLGDDRYGDLIETNGGDVVDELRATMPDVRREGFDDSDRQRLDGGLVGFLGYDAVYDLWLDEVGVERPESRFPDAEFVLATRVLTFDDVEDSIELVFTPVVRPEDDAGAIYDSLAAEAERVESLLADAEPPETGGFDRVGETAGPREEYEDAVRQAKEHVLDGDIYQGVLSRKRELYGSVDPIGFYAALREVNPSPYMYLLAHDDCSIVGASPETLVSVLDESVMVNPIAGTCPRGAGPVEDRRLAGEMLADDKERAEHTMLVDLGRNDVRRVAEPGSVRVDEFMGVLKYSHVQHIESTVTATLAEHHDAFDATRATFPAGTLSGAPKIRAMEIIDELERSPRGPYGGGVGFYSWSGDAVFAIVIRTATVESGVDPAAVPDAAAVDADAAAAIDGSLDRITVQAGAGIVADSDPTAEFEETESKMDGTLAALERIEDGAARGEGERAAPADATAERSAQGGGDGEGPATEDGTSSEGAGRSADAAADDEAHRAEEPASDQREPAVSGDDAARDGGSVDEEQPATDDTAEQEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZT1</accession>
    <name>R4VZT1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447654.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14105"/>
    <dbReference type="EnsemblBacteria" id="AGN02760">
        <property type="protein sequence ID" value="AGN02760"/>
        <property type="gene ID" value="L593_14105"/>
    </dbReference>
    <dbReference type="GeneID" id="16181062"/>
    <dbReference type="KEGG" id="sali:L593_14105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2886"/>
    <dbReference type="eggNOG" id="arCOG04550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156330_0_0_2"/>
    <dbReference type="OrthoDB" id="107877at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043903">
        <property type="entry name" value="DUF5785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19098">
        <property type="entry name" value="DUF5785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="12250" checksum="066030D25625DD57" modified="2013-07-24" version="1">MDWPHDPDDEEGSEGGRKYGMAILAKKVDEDEDFPLDVESFVAEHRDEPLRLNHQRVVSVEDVFEYVTADTFEDIVDFHKGVGKAMRTGGFWEYHPEGENPQRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZV2</accession>
    <name>R4VZV2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
            <shortName evidence="6">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="9" type="ORF">L593_09005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09005"/>
    <dbReference type="EnsemblBacteria" id="AGN01746">
        <property type="protein sequence ID" value="AGN01746"/>
        <property type="gene ID" value="L593_09005"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1847"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_043736_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="8">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="6">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="8">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="39717" checksum="75954555070EFCB0" modified="2013-07-24" version="1">MTTDDGCPECTGALAREGDETICTDCGLVVDADRLDRGPEWRSFQGEETNRERTGAPLTRSRHDRGLSTEIGHGDGSGSVRLTGRKRRRLVRMRREHSRAQIATKQDRNKVYSYTEIRRLVDRLELPQDVCEQACALFDSAQSAELLQGRSLEGFAAATVYAVCRTRSISRTIDEVVADARADESELRAAYDALNRELGLPTGPIDPAEYVPRFASALDLPDAIERRALELAALGREAAIAGGRDPSGFAAGCLYTAAQDCGHGLTQCDAADAAGVSPVTLRKAYHDLEDAKATEVTTSDGAPEDGTASDSTVSDDAASDATGSEGTAGHATPAHATAGEAESSDPDADVTIGQDDPAGRSKRSGTPAAMPFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZZ5</accession>
    <name>R4VZZ5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01796.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09255"/>
    <dbReference type="EnsemblBacteria" id="AGN01796">
        <property type="protein sequence ID" value="AGN01796"/>
        <property type="gene ID" value="L593_09255"/>
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    <dbReference type="GeneID" id="16182684"/>
    <dbReference type="KEGG" id="sali:L593_09255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1900"/>
    <dbReference type="eggNOG" id="arCOG04053">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="558" mass="58971" checksum="954A98FD9945B598" modified="2013-07-24" version="1">MEPDVDAFGSRRSTVYAPEGIVATSQPLAAEAGVETMRQGGNAFDAAVATAAALNVVEPTSTGLGGDVFALYRTADGDVGAMRACGGAPADATIENVREAVAEGRGAPEQPEVSDPANATMPEFGPHAVTVPGTARGWEATVEELGRLDFAETLQPAIRYAVDGYPVTEVVSAQWQHGEDRFTDEHAREAYLFDGEAPGVGQEVTLPKLGRSLERIAAEGADAVYEGAIGEEIAAEVQEQGGFLTTDDLADFAVEWPDPVSTEYHGAEVYELPPNNQGLLTLEALNLASEVDAGDHPYDSAERVHAFAEAMKLAFVDGHHYVTDPEFEDVPDLASKRYAAERAAEIGDLAIEDADIGFPRDASAGGGNSTGHDPAEDADTALLCAADAEGNVVSFINSRFHGFGSGLVAGDTGIALQNRGASFSLDPEHPNRLEPGKRPFHTLIPAVAKLDEDDWAAFGVMGGYMQPQGHVQVLSNILDYEMPLQAALDAPRWRYREDGSLAVEERLHDGVATKLVRKGHDVGILPPALFGGAQIVRNQDGTLSGATEPRKDGQVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W098</accession>
    <name>R4W098_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446805.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09830"/>
    <dbReference type="EnsemblBacteria" id="AGN01911">
        <property type="protein sequence ID" value="AGN01911"/>
        <property type="gene ID" value="L593_09830"/>
    </dbReference>
    <dbReference type="GeneID" id="16182823"/>
    <dbReference type="KEGG" id="sali:L593_09830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2023"/>
    <dbReference type="eggNOG" id="arCOG04717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1109537_0_0_2"/>
    <dbReference type="OrthoDB" id="60060at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043940">
        <property type="entry name" value="DUF5781"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19093">
        <property type="entry name" value="DUF5781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="27418" checksum="C7E32C78D1700BFF" modified="2013-07-24" version="1">MDVRVRGPASPAPFLSARDLLETEHDLDRPVEVRVRESPDERTWTAHDDERHVLNISRQAATSAMARPLALHEYAHMVRNEEGHVSHVQSTDEALFLALSGHSVERRKVAHCYQIANHMKDIYADDVTLSVGPPDRLVAFLESRLAAGVADRPNPPRSGAQPASVGADPELTAVHAAFGLAIVERHGLVDDDHRIYDLAHAAAKDAPAVPLNRFKRSFRELAPDPGAREYKQALVDLTQTYATGSAQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1D3</accession>
    <name>R4W1D3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447295.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12310"/>
    <dbReference type="EnsemblBacteria" id="AGN02401">
        <property type="protein sequence ID" value="AGN02401"/>
        <property type="gene ID" value="L593_12310"/>
    </dbReference>
    <dbReference type="GeneID" id="16180703"/>
    <dbReference type="KEGG" id="sali:L593_12310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2532"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OrthoDB" id="101161at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="122" mass="13595" checksum="038434798E00484A" modified="2013-07-24" version="1">MPSGTTGDAAESAARTDTTTEQGPCSLVEPFEQIGSKWRLIVLNDLLESEKRFNVLKRSTGASSRTLSRVLDDLEEMDFVTRRLEEDAPVATYYSLTDKGQSLAPMFATIEDWAAEWLDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1J7</accession>
    <name>R4W1J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447385.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02491">
        <property type="protein sequence ID" value="AGN02491"/>
        <property type="gene ID" value="L593_12760"/>
    </dbReference>
    <dbReference type="GeneID" id="16180156"/>
    <dbReference type="KEGG" id="sali:L593_12760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2618"/>
    <dbReference type="eggNOG" id="arCOG04660">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058951_0_0_2"/>
    <dbReference type="OrthoDB" id="84841at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="428" mass="45228" checksum="26827E1923BC5D42" modified="2013-07-24" version="1">MDVPGIVEEALDGEEVAATVDLGGDDALFVTPTRTLIYRSEGLLSDESVEAYSHNAESLSLSEGRRKTRITLEHPIEGTEEFTLPSSAADAAIPSILAGVLRSNDVIGEGESVVDSYLFSELTLVITDDRLVKHVGGMLWDLEFEEYPFADVTAVYAEKGSVATQLIIEVDGRAERIKTPSDRSREVRETLEDALRRFHGLRPEEDLNDALAPAEPERTDAEEESDAEASTESSGGMDFGEGVEPLSAGDTTQDGRNPDPRDLEDGSSSAPSEPAPAASESDGADRAPAEPDERAPEPDDATPEGAATEPTTDAASNETTQTDVTATADAGAAGEPESPGSDASDSPTDAGTGSSSATSPSASQPTSSGAQQPDAEFQDAGFEPATDPTEELAEEVAELRAAVQKQNKLLTRQHKTIEKLVEELRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H5</accession>
    <name>R4W2H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447785.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14785"/>
    <dbReference type="EnsemblBacteria" id="AGN02891">
        <property type="protein sequence ID" value="AGN02891"/>
        <property type="gene ID" value="L593_14785"/>
    </dbReference>
    <dbReference type="GeneID" id="16181478"/>
    <dbReference type="KEGG" id="sali:L593_14785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3019"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_3_2_2"/>
    <dbReference type="OrthoDB" id="12601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="195"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="445" mass="49552" checksum="B0E18EBA2A9D2858" modified="2013-07-24" version="1">MTAVGIDAMEIWVGNLELDLPGTFAPAQGEDPGKYTKGLGLHSSSFPDSYEDIVTMGANAAHRLMDRKGLEPEDIGRIDVATESAFDNSKPVSTYIAGCLEQVYEGDFHHANKGERKFACISGTQSVNDAFNWIKSGRSRGRSALVIATDTALYARDDPGEATQGAGAVAMLISEDPSLVELSTEQGFGSADETDFLKPQQQFPSVDGKRSMQVYLARMREALEDYEAIAEDIHPDSFAYIPFHTPFPGMVRKAALLAYRHTSRDTDVEDSLAEEIGRQPRESEFEDRESYEDAVREYTDALAETETYQSWYEAVVEPTLSISREVGNWYTGSVHIARASALRHAYQNDVDLEGKTLGVGSYGSGAQAEVHAEYVQSGWREEIEAMNVEEQLDSRYDLTFEEYETIHDAHNHDLDTDIEALTTPENEFVFDGWGRMGERQYSYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H9</accession>
    <name>R4W2H9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">L593_14810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14810"/>
    <dbReference type="EnsemblBacteria" id="AGN02896">
        <property type="protein sequence ID" value="AGN02896"/>
        <property type="gene ID" value="L593_14810"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3025"/>
    <dbReference type="eggNOG" id="arCOG00100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_3_1_2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="26070" checksum="B23AEC4353E55FB1" modified="2013-07-24" version="1">MPSTDEPGADSIENERPDILGGRLEELLDGPGIFVAGTDTGVGKTIVTAGLTGVLRERGVEATAIKPAQTGAPADDDAALVANACDDPAASTCLERLDPALAPRVAAERENVDLSYDVIRDDCEAAVDASGFPVVEGIGGLRVPLTDDREVIDLIVDLGLPTLVVARSGLGTLNHTALTVDALRDRGVAVPFVVLNEYDGATVAERTNPAELRRMLDVPIATVPTFEASDPAAIVPAVRSALAGSGGQDGDAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2N0</accession>
    <name>R4W2N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00435"/>
    <dbReference type="EnsemblBacteria" id="AGN00042">
        <property type="protein sequence ID" value="AGN00042"/>
        <property type="gene ID" value="L593_00435"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.89"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="474" mass="49590" checksum="D2837F77621EB646" modified="2013-07-24" version="1">MSKQSRRENLTDGGLARPLARLAWPIVVIQLLQVTYNIADTIYLGWYDPTAVAAISLAFPLLFLIISVAGGFTTAGSILVAQYTGAEGERSAGRVAGQTLAFVGSLSVLLAILGFLVVDPALAFLPTEAETGQEVVPQMAAYLKVLFLGLPAIFGFFVFSALMRGYGDTRTPMRIMAGSVALNVVADPILIFGLGPAPELGIVGAAIASMGARGLATLAGLHVLFRTNRGPSVSTADLPFNVEIIRQILSIGVPSALEQSMAAVAMVTLTAMVAQFGPPVAAAYGVGNRLVSLVFLPAMGVGRATNTMVGQNLGADKADRAERAVWLGVAVSGGVMAVVALVAYAVPEPIVAAVIGADTEYTAESIALGTDYLRIRSIEFVFIGIMQVVLGGFRGAGNTRTALAISMVTLWVARVPTVFYLTVVQDWGPTGIWIGMTIGHILGTLVAVPWFLRGTWKEAVIDEDDPRGPSAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Y8</accession>
    <name>R4W2Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445101.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01270"/>
    <dbReference type="EnsemblBacteria" id="AGN00207">
        <property type="protein sequence ID" value="AGN00207"/>
        <property type="gene ID" value="L593_01270"/>
    </dbReference>
    <dbReference type="GeneID" id="16180485"/>
    <dbReference type="KEGG" id="sali:L593_01270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.259"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_1_2_2"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="76" mass="8138" checksum="07A71D60221901CA" modified="2013-07-24" version="1">MVTAYVMIKANTGDADRLRSEIDDIEGVVDTHIVAGDVDLIAKVEVESPGKVKDVSATSIQAIDGVEDTRTYIAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W321</accession>
    <name>R4W321_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445156.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01545"/>
    <dbReference type="EnsemblBacteria" id="AGN00262">
        <property type="protein sequence ID" value="AGN00262"/>
        <property type="gene ID" value="L593_01545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180103"/>
    <dbReference type="KEGG" id="sali:L593_01545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.314"/>
    <dbReference type="eggNOG" id="arCOG01190">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052133_0_0_2"/>
    <dbReference type="OrthoDB" id="67700at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="29532" checksum="A72A9C1A2CB88E52" modified="2013-07-24" version="1">MDLRELVRGTVDWETLEAIARELAERSDRDVVRIEFMEADNWLSTPLVVDEEWFVKVITPQNARVHGVLTGARNLGMFSRGTEGFFSRFDGPVEMGEHEIEATRRMREIGLDAPEPLEVFEAQGLGVVVLEYLDDYRTLEDLDVEALDGVATSTAAALSTMHEHGLAHGDFREENVLVVDETPHFIDATLVDEAGLADARAYDLACLLAVLEPRIGAARTVEIAAASYDVETVLDASRYLDFVNLRPDHEFDAALLKGEIEKTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Q4</accession>
    <name>R4W3Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445571.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03630"/>
    <dbReference type="EnsemblBacteria" id="AGN00677">
        <property type="protein sequence ID" value="AGN00677"/>
        <property type="gene ID" value="L593_03630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180607"/>
    <dbReference type="KEGG" id="sali:L593_03630"/>
    <dbReference type="eggNOG" id="arCOG02917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
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        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="20286" checksum="5D8E822C5E9A4C69" modified="2013-07-24" version="1">MNETRSSTVSRREALTAAATALAGGAIATDDVEAQEQTVIDMTDDLVFAPDSVTVAPGTTVVWENVGQIPHSVTAYEDEIPEEAEYFASGGFENEQDARSSYPDGEIVGGDSYERTFDVEGEYGYFCIPHEANGMVATLTVAAGGGGGDGGGAAGPPEVTDDALSLAIGLMAALGSVIGLVFFFLKYNVGATEEPE</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
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            <end position="254"/>
        </location>
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            <begin position="404"/>
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            <end position="419"/>
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            <begin position="50"/>
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            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="467" mass="48062" checksum="896DB3F31B6952B9" modified="2013-07-24" version="1">MTGEEVSTASESDGPPGIQANDVVASFGAESVLEDVSATVARGELVGLVGPNGAGKTTFLRTISGALAPDDGEIRVVGDSIAALSSAAASRRIAVVPQTTHLSFAFSVRELVEMGRHPHRSRFDPPSREDRALVEAAMERTDTARFADRSIEDVSGGERQRVLLARAIAQDAPVLLLDEPTASLDLHHAVETMAMVRDLVDEDDAAALAAIHDLELAARFCDRILVLAGGAIVAAGPPEDVLEADILEAAFDARIAVEHSPLDGGVTVRALADPELDRRVHVVGGGERAASALGRLGEAGASLSLGPVPAGDRAVSTAEAVDAEPVTVPPFAPADGGAIERALDLAAEADAVVLAATDLPEAWRRCVTGTDTPLVAVGEGPVPVEGALRTDPDSLPGTIEAVARRSADTAKESRNRRALADATVADGGVDVDVDGVPDGDADEETNLDADQETDVGVDGETDGDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Z1</accession>
    <name>R4W3Z1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="62"/>
            <end position="188"/>
        </location>
    </feature>
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            <end position="149"/>
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            <begin position="164"/>
            <end position="188"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00807.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="188" mass="21430" checksum="78835E9C79B69B3F" modified="2013-07-24" version="1">MYEERFGTDWEEIEDREEAVRRAFALGVAARMDEHYPGELDRISDQVESTYDRSFVELAFHEGRDKADRIDPDPAADAGDVWEEVVEGTTQLDPSDRPEQGQAHEKQGIPDALGGYQIDSRPDDSRESVGRPKFLSRDEAQEPEHRRRGRNRSQQRSSGSGDGDDDDQLSEEDREEFEEILDPDSDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
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    <name>R4W4V4_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="22551" checksum="DF9640FC3C9FA4D3" modified="2013-07-24" version="1">MAQTIYSKLIEFTPVENQLGAIKEILRTVREHAPLPVDTIYEIRGPSNEEQTSRYLRLLEDTDFIQIDDDTLRSDSNLDVHDELEVGTREFSEIVLGQVVNRAFSTLRDELNLTLLAHYPKYANSYYFSALQRGQPNLKLDVESAHDNLEMLHEESVHEIKVQQKLDDLAKVGVLETEGEFYKSNPEIYGDLAAQPV</sequence>
</entry>
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    <accession>R4W4X2</accession>
    <name>R4W4X2_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01382">
        <property type="protein sequence ID" value="AGN01382"/>
        <property type="gene ID" value="L593_07175"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_07175"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9476" checksum="773EA9702F0B62B1" modified="2013-07-24" version="1">MSAPPEDGTTASGSGDPPAAAQAAEEINGSGEVSRLRSRVSQLETELERKDAEIEAVRRQYEAILDRESYDVPAERQNDRSGLFGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W520</accession>
    <name>R4W520_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/Ca2+-exchanging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NaCa_Exmemb"/>
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        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="70"/>
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            <begin position="186"/>
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        </location>
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            <begin position="211"/>
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    </feature>
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        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="255"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="469" mass="50430" checksum="24333A81320E7527" modified="2013-07-24" version="1">MVFDRLRHPIWALVFALGLTVPWVLIYLTGSVHAIGVGPRVALSGIAVLGASFLLAWGAETAEKDVPRAFAIAVLAVLAVAPEYAVDALYAWQAGSGGATAEACSGVSKSAMEQGSTELARACHDANLAVANMTGANRILIGLGWSGIALFTVWKAWQGRADANVADTDRFRDGAVSIDPDLSLEILFLLLATAVAFTVPFMGGIDALDTIVLVGLYVVYISVVIRGDVEEHDEQVGVPLYLQRKSFPVRSAASISLFLYSGIMIFTAVEPFAHGLEEIGLQYGVPEFFMIQWIAPLASESPELIVVAYLVNKARSTAAFNALISSKLNQWTLLIGTLAVVYSIALGQYGTLPFDSKQAAEIWITAAQSLFAIAILVNFRISVKEAVGLFALFFSQVVIEFGIIRLVGEPEATEYSILLLEGYTVVYLLLSAWLFYRRRGALREIAGRSKRTIADAYGFGGTGEETATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5E3</accession>
    <name>R4W5E3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prepilin signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN01682">
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        <property type="gene ID" value="L593_08685"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1780"/>
    <dbReference type="eggNOG" id="arCOG02298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065732_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Preflagellin_peptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06847">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="87"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Arc_PepC_II" evidence="3">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="410" mass="42978" checksum="67231BB6FE3E0452" modified="2013-07-24" version="1">MPGFSGAKNAFGNTFGDAQASDEHLSAIGEQAVRTHRHPSGSVGGVPTVAGTLKRLPVAVPSVFHESLVEVGPVLARPTDLLRLLALPAFAWAAWTDVQIRRVPNRLWPPLAVLGFVLLALDAHHYSQVGGNTWRLFLIGAGLSVGVVVPLVYAFWLLGGFGGADVKALATLSILFPVFPEFFVDGTAYPLVDTTAGAFAFTILTNAVVVGMAYPAALALLNLAKGNTSRWMVVGKKVDWRALPGAHGRLLETPDGFSRDGLDLDALRMYLRWRGIDLADLRANADELRDPATLPEDPNPPSDGAVAAEEALVTDGGAAAADGTATDAADSAPDDYDDPWGAQAFLDDLDGGAYGTDPAKLRGGLDVAAERDAVWISPGIPFIVPVFLGLVLALVYGDVLFGVLSALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5K7</accession>
    <name>R4W5K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01782">
        <property type="protein sequence ID" value="AGN01782"/>
        <property type="gene ID" value="L593_09185"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1884"/>
    <dbReference type="eggNOG" id="arCOG10180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409188_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0701">S-layer</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="679" mass="69379" checksum="1F23035F9864ADB7" modified="2013-07-24" version="1">MAAIAGAATVSASTTTTSAQDGMDAASVSFSNQTSGGTTVTVDEVTLPEGGFVTIHDDSLTDGDTFGSVVGTSGYLAAGTHENVTVTLESGQASGTYHAMAHQDTNGDRAYSFVASNGEADGPYTMDGNIVMDAAEVTATATVTASDQPTTGDSLIVDRVELAEGGFVTVHDSSLADGDVFPSIRGTSAYLPAGVHEDVRVQLDSPLNESDQVFYMAHQDTDGDENYTFAASEGEADGPYTDAAGEIVMAPAQATVSTTASSTFDAQTTGGNHVVVDSVFLPEGGFVTMHDSSLGDGEVFASIRGTSEFLAPGLHRDVTVLLNDSLSANDTLFAMAHQDTDGDETYTFPEGEGGEDGPYTNENGDIVMDDGTVSVAASVDFAAHSSDGTTVTVERVDLSEGGFVTIHDETLTNGSVFGSVRGTSEYLEPGVHTDVTITLDEPVDESHTFYAMAHQDTDGDETYTFLESEGENDGPYTAGGSIVMTAAMVDVPAHVTIGDQTAENGETITVDAVTLQNGGFVTIHDATLADGAVFDSVRGTSSYLGPGTHTDVEITLTTPLEESGSVFAMAHYDTDGDEAYTFLESEGAADGPYVANGAPLMGSAAIEVPSDDGDGSSDGGADDGSSDGDDGSGDGMDDGNMDDGSDADDSGSSDGSPGFGIAVALVALLGAALLARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5M3</accession>
    <name>R4W5M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446716.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09385"/>
    <dbReference type="EnsemblBacteria" id="AGN01822">
        <property type="protein sequence ID" value="AGN01822"/>
        <property type="gene ID" value="L593_09385"/>
    </dbReference>
    <dbReference type="GeneID" id="16180114"/>
    <dbReference type="KEGG" id="sali:L593_09385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1930"/>
    <dbReference type="eggNOG" id="arCOG06293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387543_0_0_2"/>
    <dbReference type="OrthoDB" id="104008at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="20807" checksum="5D20F0EA9E59BCFA" modified="2013-07-24" version="1">MISLPTSRSDWRLLGRTIRLVLGHPSYLVFAIVVTTAVAILISVTQNLRFVVEVLLSDSLGLGFKVEFLTAMLPFLGPQYDATHGVLIYAVAGLTGANVALLAYHLLEHDLSVEGGGGSAAGVVLGTLGAGCAACGPGILAGIVGIVGGAGLLANLPYEGLEFSMLAVVVLVLSMYWLADGMRGGEIRGCPVDPEMLRTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5P9</accession>
    <name>R4W5P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446766.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09635"/>
    <dbReference type="EnsemblBacteria" id="AGN01872">
        <property type="protein sequence ID" value="AGN01872"/>
        <property type="gene ID" value="L593_09635"/>
    </dbReference>
    <dbReference type="GeneID" id="16182511"/>
    <dbReference type="KEGG" id="sali:L593_09635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1984"/>
    <dbReference type="eggNOG" id="arCOG04618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_2"/>
    <dbReference type="OrthoDB" id="87906at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="13677" checksum="225054A954DB192A" modified="2013-07-24" version="1">MSDSEDLNVLGEPLTPCSLDPETGYERDGYCRDILADAGRHEICAVMTEEFLAYTAAQGNDLRSAQPELNFPGLDPGDRWCVCVPRWLEAEEADCAPPIVPEATAKSVLTHVCRDTIEAYAADTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X5</accession>
    <name>R4W5X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin 2Fe-2S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2Fe2S plant-type ferredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00440"/>
    <dbReference type="EnsemblBacteria" id="AGN00043">
        <property type="protein sequence ID" value="AGN00043"/>
        <property type="gene ID" value="L593_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00440"/>
    <dbReference type="eggNOG" id="arCOG02843">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1405948_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010241">
        <property type="entry name" value="Fd_pln"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02008">
        <property type="entry name" value="fdx_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="20757" checksum="3682DE104D4CED51" modified="2013-07-24" version="1">MELGLAFAVGVGLTVLTVLVHFSRGTGWSPNEDISQAVLEQRAQTVPETDFPEPSNRTFSAGGGAAVAAVGEGEEGTELEEGEEESSSPGDIPEDEIEYFDVEFVKEGETIEVVNNEPLLDQGEDHGWDLPYACREGQCVSCAGHIPDGDARDFVEHDDQEMLDDPELEDGYVLTCVAYPRADFSLETSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y7</accession>
    <name>R4W5Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444957.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00540"/>
    <dbReference type="EnsemblBacteria" id="AGN00063">
        <property type="protein sequence ID" value="AGN00063"/>
        <property type="gene ID" value="L593_00540"/>
    </dbReference>
    <dbReference type="GeneID" id="16180839"/>
    <dbReference type="KEGG" id="sali:L593_00540"/>
    <dbReference type="eggNOG" id="arCOG03953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2784207_0_0_2"/>
    <dbReference type="OrthoDB" id="120146at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="67" mass="7544" checksum="017F0B480212BAF9" modified="2013-07-24" version="1">MPRQWEYHTIEPPKGLTKRETVDPTEELNRLGAEGWELAETISYDKGGTKLLVFKRPVTDSDSPGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W655</accession>
    <name>R4W655_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMP cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">IMP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Inosinicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purO</name>
        <name evidence="6" type="ORF">L593_10885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal IMP cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447016.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10885"/>
    <dbReference type="EnsemblBacteria" id="AGN02122">
        <property type="protein sequence ID" value="AGN02122"/>
        <property type="gene ID" value="L593_10885"/>
    </dbReference>
    <dbReference type="GeneID" id="16180047"/>
    <dbReference type="KEGG" id="sali:L593_10885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2246"/>
    <dbReference type="eggNOG" id="arCOG04727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352116_0_0_2"/>
    <dbReference type="OrthoDB" id="106750at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00705">
        <property type="entry name" value="IMP_cyclohydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010191">
        <property type="entry name" value="IMP_cyclohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020600">
        <property type="entry name" value="IMP_cyclohydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036795">
        <property type="entry name" value="IMP_cyclohydrolase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07826">
        <property type="entry name" value="IMP_cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004866">
        <property type="entry name" value="IMP_cclhdr_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75569">
        <property type="entry name" value="SSF75569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01922">
        <property type="entry name" value="purO_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP_cyclohyd" evidence="5">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="21040" checksum="CD15C6C983734511" modified="2013-07-24" version="1">MYVGRFVVVGPDVAAYRVSSRSFPNREIRDRDGTLTVGPTDDAPPTDNPYVEYNCLRTTDAGPRDGAAAVLGNGSQVDPILEKIELGYPARDALAESLLALDYEKDDYDTPRLAGVLDEDGAHVGIVRKDAVLVKRVEEPTLVATYERDAPGPVEFEASAAAEAAAEAYDFDFEHAVCAAGVARSGDGFETAIENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C0</accession>
    <name>R4W6C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_01675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445182.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01675"/>
    <dbReference type="EnsemblBacteria" id="AGN00288">
        <property type="protein sequence ID" value="AGN00288"/>
        <property type="gene ID" value="L593_01675"/>
    </dbReference>
    <dbReference type="GeneID" id="16179909"/>
    <dbReference type="KEGG" id="sali:L593_01675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.340"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043913_0_0_2"/>
    <dbReference type="OrthoDB" id="15997at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="REPA_OB_2" evidence="4">
        <location>
            <begin position="303"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="539" mass="57019" checksum="559CB0825B7B72F5" modified="2013-07-24" version="1">MGVIEEIHEDLEADVELAEFRDAVEERVERMGGLADEETAAMLVAHELDEDGGEVEGVAEIEAGMEEVKFVAKVVSVGELKTFERDDDGSENDDVDETEAEEEPAAREEGAAQDEQSNEGRVLNAEVADETGQIRVAFWDALATDAAERMERGDVVRIAGRPAEGYRGLEVNVDKAEPDPGVEVDVDLEGTTSIDDLTLGRSDVNVEALVLDTESVRTFDRDDGSEGKVSNLALGDPSGRIRATLWDGMADRAEELEPGTSVEVVDGYVRERDGDLELHVGERGAVEEIDESVEYEPDSTPIGEVEIDQQVDLVGVVRSADPKRTFDRDDGSEGQVRNVRVQDDSGDIRVALWGDKADLDISPGDELALADVEIQDGWQDDLEASAGWQAAVTVLERDDGLPAGGGGTADGDADLSAFGDDGSGDSGDEAASEGATDDAESSGAERPVAEAADATAEGPGAQRGTSSESVDDADDDAVVAVGETVEFTGVVVQAGDPIILDDGEQTVRVDADADIHLGDEITVRGEGVEDDRIAAADVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C8</accession>
    <name>R4W6C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445197.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00303">
        <property type="protein sequence ID" value="AGN00303"/>
        <property type="gene ID" value="L593_01760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181826"/>
    <dbReference type="KEGG" id="sali:L593_01760"/>
    <dbReference type="HOGENOM" id="CLU_1192663_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="24205" checksum="679FA6CA11EDD639" modified="2013-07-24" version="1">MSTDIPRLDRRTVIKGVGGAGAAGVVGGLGLFALSGTVAAADTSLEASNPSAVTTDDGEIQYVAFGGRLRFEWDGLDEEATYGWYRVESRVNTGGGWSNWRSHGSDYGELGANWGGSNDYTQDTGTDGIFQFKYGAPYGQQSYAIAGSGSNLLDSANKYDVSVFEADSDGGTQETDVHIRMTCRVYDGEPGSGGSVLIEQADGATFTVTVNNRTAMATTGGEITPTVGADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G1</accession>
    <name>R4W6G1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445257.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02060"/>
    <dbReference type="EnsemblBacteria" id="AGN00363">
        <property type="protein sequence ID" value="AGN00363"/>
        <property type="gene ID" value="L593_02060"/>
    </dbReference>
    <dbReference type="GeneID" id="16182348"/>
    <dbReference type="KEGG" id="sali:L593_02060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.419"/>
    <dbReference type="eggNOG" id="arCOG04557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179752_1_0_2"/>
    <dbReference type="OrthoDB" id="123038at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="73" mass="8227" checksum="4E4497FEF2176DE3" modified="2013-07-24" version="1">MAESSVSDERIEETESWPELAIGLYDRLTGRGAEIVYEFDDMAVEVPSKTGADAEHAHWELDGTLKITTRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P2</accession>
    <name>R4W6P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02442">
        <property type="protein sequence ID" value="AGN02442"/>
        <property type="gene ID" value="L593_12515"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2569"/>
    <dbReference type="eggNOG" id="ENOG502N5FS">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="21776" checksum="326EBEC1DC085B76" modified="2013-07-24" version="1">MSSTKDSPTDDSDRTPWDELSTARQRVVLTIAHVHGPQTFNRPDLCDDVAGADDVEDVIDDKDRVLTSLDYTRLLNDLTEDGYLVKEFQGGTNPIILDVEYDSDRDTRNAAPWGNASALHTLVDQVCEREGITRDLLDEVDNEYDFNEVKNKVNGVVGRTVLQPYADPSKYRFTKEGYSLVFEKVEAARDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U4</accession>
    <name>R4W6U4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein transport protein Sec61 gamma subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secE</name>
        <name evidence="10" type="ORF">L593_03135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445472.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03135"/>
    <dbReference type="EnsemblBacteria" id="AGN00578">
        <property type="protein sequence ID" value="AGN00578"/>
        <property type="gene ID" value="L593_03135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180465"/>
    <dbReference type="KEGG" id="sali:L593_03135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.634"/>
    <dbReference type="eggNOG" id="arCOG02204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191921_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="55" mass="5972" checksum="302BCA3FC2DFCE16" modified="2013-07-24" version="1">MRVPTDLSSYVRVLRMASTPSWEEFSQVAKIAGAGILLIGMLGFVIFLAMSLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z9</accession>
    <name>R4W6Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447506.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13365"/>
    <dbReference type="EnsemblBacteria" id="AGN02612">
        <property type="protein sequence ID" value="AGN02612"/>
        <property type="gene ID" value="L593_13365"/>
    </dbReference>
    <dbReference type="GeneID" id="16180569"/>
    <dbReference type="KEGG" id="sali:L593_13365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2734"/>
    <dbReference type="eggNOG" id="arCOG04578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656846_0_0_2"/>
    <dbReference type="OrthoDB" id="87054at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043811">
        <property type="entry name" value="DUF5793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19106">
        <property type="entry name" value="DUF5793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="157" mass="17495" checksum="D9913F790876C2C0" modified="2013-07-24" version="1">MRRDYFSLEVEDVDWIEDDGDPAKPCVTIDFEGPAAALEERFADGDEGLLDAEQTDVAFRLQDDLDAEDAAGVVSVTNRITGDFVLELNEDADDVLAFIRAARRYGELDADEDGGYDVRVLIDGEPFLEYEKRTFLVYNDAGNLLRNHSLIPSGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W783</accession>
    <name>R4W783_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445712.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04335"/>
    <dbReference type="EnsemblBacteria" id="AGN00818">
        <property type="protein sequence ID" value="AGN00818"/>
        <property type="gene ID" value="L593_04335"/>
    </dbReference>
    <dbReference type="GeneID" id="16180911"/>
    <dbReference type="KEGG" id="sali:L593_04335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.882"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_0_1_2"/>
    <dbReference type="OrthoDB" id="71240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="28235" checksum="7F522CC8A681BCD1" modified="2013-07-24" version="1">MTVRYDGLRFDWFGYATARIEAPDGTVVYTDPGRYGTLDGTWESEYGGAPENLDDAHPHGPAYDAQDADVVVVTHDHHYSDDGVERVASDDATVVVYEGVSADGVAANSGRDVVEPEELPYDVVRVGYGDDLTIAGVEVDVIPAYNEPGGPDAAPDIDVTHPYELGCGYVVSVDGTRCFWTGDSDAIPEHEGLDVDVFLPTIARSFTMDRHEAADLAAQLDPGLVLPIHYNTFDALGSDSAAFAADVAKRSVPVALDEGWPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W786</accession>
    <name>R4W786_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04360"/>
    <dbReference type="EnsemblBacteria" id="AGN00823">
        <property type="protein sequence ID" value="AGN00823"/>
        <property type="gene ID" value="L593_04360"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.887"/>
    <dbReference type="eggNOG" id="arCOG06301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286328_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="24793" checksum="ADDE8893B8E3EA82" modified="2013-07-24" version="1">MQRRTYVAGIASALTAGLAGCSALGSGGDGDDGSDGSGTDNTDGNNSHGDGGTGDDSGGGNGTDPGGDPPSPSLVNGSFEDGLEGWTVGKDLPPKPGEDSGTVDHDVTTSSDTGIEASDGETVLKFTLSGRADDGTLWVEQEVDFADAATVELDVYSEQESFNEIGQIAVFAGEKPEGGLVEEDFNREHPTENHQGWKTFRYDVADLTGTGTLAVGLNIVWETEIVRLYDDVQLVTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q3</accession>
    <name>R4W7Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01113">
        <property type="protein sequence ID" value="AGN01113"/>
        <property type="gene ID" value="L593_05820"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05820"/>
    <dbReference type="eggNOG" id="arCOG10761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2839317_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="8000" checksum="79AD4547FCB3AD9B" modified="2013-07-24" version="1">MSLAARPTGMEDRRRTVVGVIWLFVAVLAFAAADPGESLLRTAVGLFAVALALWLAVLYLFDPWDILERYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T2</accession>
    <name>R4W7T2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444933.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00420"/>
    <dbReference type="EnsemblBacteria" id="AGN00039">
        <property type="protein sequence ID" value="AGN00039"/>
        <property type="gene ID" value="L593_00420"/>
    </dbReference>
    <dbReference type="GeneID" id="16181510"/>
    <dbReference type="KEGG" id="sali:L593_00420"/>
    <dbReference type="eggNOG" id="arCOG03850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878850_0_0_2"/>
    <dbReference type="OrthoDB" id="51977at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="35638" checksum="DAFA462EEF5A2043" modified="2013-07-24" version="1">MTLLESVAERVPEDAKPRIDRLAHFVVPWMSWRKRRRVHRTEEAFVDRFFPSPADFEAYEQEFFAGRIVDICRSAAEELSTDGSIYDAHMDECARLYALVREYEPTTIVETGVYHGVSTASLLLALDENDAGTLYSLDPVPLLQGTPQDAEAPALADGRGATIAQPRRDYYERGRPSCSEAGTHRIPEDREAGWIVPDDLHDHWDRRTGRSQRDLPGLLDSVGGVDLFIQDSEHSQTGMAFEFDLAWEHLVPGGLLVSFHVDWNDAFDAFVEERGCAHGPLAYTYNGFEDYETACTSAYAIKPARRRPKPFAELDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V8</accession>
    <name>R4W7V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06455"/>
    <dbReference type="EnsemblBacteria" id="AGN01238">
        <property type="protein sequence ID" value="AGN01238"/>
        <property type="gene ID" value="L593_06455"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1315"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="115"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="559"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="671" mass="74148" checksum="8C2ECF94E1784F99" modified="2013-07-24" version="1">MTMTREDAQRSESFAFEPEESFVESTNVWQFMQEYGIDDYDELIERTTSEVPGEPDSGVEWFWDELVDYLGIEFYEDYERVRDDSDGPQFTDWYPGGELNVAHNVLDRHAAVDAEARNSVALIWEGEPGDVREVTYHELHREANRVANYLESVGIETGDTVGLYMPMVPEVVSILYGCLKVGAIAVPIFSGFGVDATATRIADSECSVLFTGDGFYRRGSEVVLKDTADEAIEAAGHVEHTVVVDRIGASDGAVDVGWDDERDAWWADAIGPQPDEYATKHLPSDQESMLLYSSGTTGEPKGIVHTHAGILTQCAKEIHFGFDQQPADRFFWVSDIGWMMGPWTLVGNHTFGGTVFMYEGAPDHPEPDRFWRMIDRHGLTQFGISPTAIRALRKHGEEWLEGHDLSSLRLLGSTGEPWDPESWQWFLEHVGGGECPIVNISGGTEICGCFLMPMPIQSLKPCTLGGPGLGMDIDVVDAEGNSVADEHERGYLVAKDSCPSMTKSLWSGDERYLEEYWSTWEDLWDHGDWAQVDEDGLWFLHGRADDALNVAGRKVGPAEVEGAAMEHDAVNQAAAIGVPDDTTGTAVVLYVVPEPDVDPDSDLAEGIMETVGEEQGKPFRPREVLFVDAFPKTQSGKIVRRAVQAAYTGEELGDLSSVENPEALDAIEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y6</accession>
    <name>R4W7Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_01080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445063.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01080"/>
    <dbReference type="EnsemblBacteria" id="AGN00169">
        <property type="protein sequence ID" value="AGN00169"/>
        <property type="gene ID" value="L593_01080"/>
    </dbReference>
    <dbReference type="GeneID" id="16181800"/>
    <dbReference type="KEGG" id="sali:L593_01080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.221"/>
    <dbReference type="eggNOG" id="arCOG00926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="42569at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="27539" checksum="22AE4DD557FDB0DD" modified="2013-07-24" version="1">MTLLEIDGLTKRFGGLVAVDDLSFSVEEGEIVGLIGPNGSGKTTVFNCIMSTYTPTEGRIQFNGHDVTDDKTYQVVNHGLSRVSQESNPIDLLSVGANIKLFTLPNSFLACALPDAILARRSDGGPGIVDHAERVGLGDKIEETPDSLAHADVRRLEIAKALATDPDMLLLDEPFAGMNQAEIRELSEQIEQFREEGITMIVVDHNMRGLMQLVDRVVVLSSGQKLAEGEPEEIVDDEAVQKAYLAGEHGGIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W844</accession>
    <name>R4W844_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445193.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01730"/>
    <dbReference type="EnsemblBacteria" id="AGN00299">
        <property type="protein sequence ID" value="AGN00299"/>
        <property type="gene ID" value="L593_01730"/>
    </dbReference>
    <dbReference type="GeneID" id="16179926"/>
    <dbReference type="KEGG" id="sali:L593_01730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.351"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031172_0_0_2"/>
    <dbReference type="OrthoDB" id="46757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="34541" checksum="7909C86AFD7152E0" modified="2013-07-24" version="1">MADLRQHAEEIRDRFEDHLDVDVEEVQERLETLVEQYAVPVEEARRSVESTYREEAGIEREDVAGGSSDLVELAAIDAPEEWVTVEATVADLWEPRSDSIAQVGLLGDPSGTIKFTKWDTSDLEELEEGQSYRLGNVVTDEYEGQFSVKLNRTTTIQPLDEEIEVGDDSEEIEGALIDVQSGSGLIKRCPEEDCTRVLQNGRCSEHGDVEGEFDLRIKGVLDDGNEAREVIFNQEATEDLTGIELEEAKDMAMDALDTEVVAEEMTTDVLGRYYRVSGPTFGRYLLVDEMERLGAPDGIEETLIKARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W851</accession>
    <name>R4W851_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01840"/>
    <dbReference type="EnsemblBacteria" id="AGN00319">
        <property type="protein sequence ID" value="AGN00319"/>
        <property type="gene ID" value="L593_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01840"/>
    <dbReference type="eggNOG" id="arCOG03052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049558_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="42139" checksum="2B2F3DAA5EF26325" modified="2013-07-24" version="1">MTGAGAVGLQSAGQNDTAQDVQPQPAPGDLALPERVVLPGDLRSGTTVVDTNVRASVDRSGSRLDGAYDRYLLDAQLAQADNDTRRQQLLAETVSGMNRSIERLHAREKEVRRAYLRGGMSTQTFLAELRAIDEEARQLERLADDIDPIDPQSDGHADVYSASDASIELGTLRGDIIALRGPVRQQVGDAMTGSSSPQRLYAFASANGTVLSTIDGDTYHREAYRSDLLVGGSERGISPTEVADLTVEELYPVYRSNYDFGSVGQGVSGQFYLVLGEGALNYEHGALRSYVDAVSENVFWEYQRMALDETLPVGAASTNETGNLTVSVRPTYDTGPARVTVTEGGEPASNVTLAVEGTVVGETNADGTAWVVLPRNGSDVSVSTGDASASVSVTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W857</accession>
    <name>R4W857_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="19" type="ORF">L593_07815</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446402.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07815"/>
    <dbReference type="EnsemblBacteria" id="AGN01508">
        <property type="protein sequence ID" value="AGN01508"/>
        <property type="gene ID" value="L593_07815"/>
    </dbReference>
    <dbReference type="GeneID" id="16182230"/>
    <dbReference type="KEGG" id="sali:L593_07815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1601"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OrthoDB" id="91297at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AGN01508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="26253" checksum="689F1C990316BD8E" modified="2013-07-24" version="1">MSNAAAGAVGHDELAVLKLLALEGGLDGEVKTSCGALGDSVGASTQTASRRLQRLEDAGLLERDTVSDGQWIELTEDGERELRNEYEDYRRIFEGVSRVALLGTVTGGMGEGRHYITLPGYMEQFRERLAYEPFPGTLNVDLTEASVRRRGALEAMDPVPIDGWEDDERTYGPAVCYPATIAKSDPDAGDEDPPAYDGAHVIAPERTHHDEDQLEVIAPDKLRDELGLDDDDHVTVTVRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A2</accession>
    <name>R4W8A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445358.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02565"/>
    <dbReference type="EnsemblBacteria" id="AGN00464">
        <property type="protein sequence ID" value="AGN00464"/>
        <property type="gene ID" value="L593_02565"/>
    </dbReference>
    <dbReference type="GeneID" id="16182485"/>
    <dbReference type="KEGG" id="sali:L593_02565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.520"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_2"/>
    <dbReference type="OrthoDB" id="72644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="26154" checksum="74D57DAE835BE2A8" modified="2013-07-24" version="1">MRIARLLTPEGPVTGEYDDGVVQTEDGFYEVGRDGRLLPPCEPSALYCVGRNYATTLDQMDYERPEEPDFFIKPATSLLAHGQPIPYPSFTDELTYAGELAAVIDERCRNVAEDEVADVVRGYTILNDVDALDQQGRTARKAFDGSAPLGPWIETDLDPSAIDVHTDVDGERRQEANTELMLFDVETVVSYLSERFTFRPGDVVAFGSPENPGLVEPGDDVEITYGGIGTLRNVVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G9</accession>
    <name>R4W8G9_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidases/acylaminoacyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AGN01763.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01763">
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        <property type="gene ID" value="L593_09090"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_09090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1864"/>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_4_0_2"/>
    <dbReference type="OrthoDB" id="15633at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="418"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="631" mass="70140" checksum="FC9465E18C4F7F23" modified="2013-07-24" version="1">MSKQSESENVLESLASLPSFHHPTASPDGERVAVYYDDTGRNELHLIDVGSGERTVVTDGEVPRNARWPMEWGPDGETIYYHQDEGGNEQNDVWRIDRDGKKAEPVVELDSQVSLEAVADDGTVYVGSTAGGQMNLYRQLPAARDDGEREIEQLTEYERAVWGGEVSPDGDRIAYATNESDVYDNLDVYVANPDGSEPRNLEIGEVGSESAPTEWDEAGEQLLLSDNVADMSRAGVYDFDAEEVTWYGDAEYEEVPVGFTDDESGILVVRTRRAAKVPVVYDLESGEGRELDVPEGVTVPAGGGAGASAGSPLLSEDRLLLTHTTPARRPELLAYDLDADETEVLLEAAYGPFDPEDFADAEYFRFESDGIPETSQAAVEHDPYDELEIEALFYDSGERPSPLIVNPHGGPRHADSRSFDLYTQFLAQQGYSVLKINYRGSTGRGKAFVEELYEDWGGAEQGDVATAAEVALDRYDFLDDDRVVVFGGSYGGYSAYWQLVQYPDLYDAGIAWIGLTDLNAMFEETMPHFRTELMEKNLGTPEQNPDLYRERSPIEYADNLAAPTLMVHGVNDRRVPVSQARLFRDRLEELGYEADEDFEYVELGEEGHASSDIDQKIRLFETLADFLERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T7</accession>
    <name>R4W8T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="R4W8T7"/>
    <dbReference type="STRING" id="1333523.L593_10665"/>
    <dbReference type="EnsemblBacteria" id="AGN02078">
        <property type="protein sequence ID" value="AGN02078"/>
        <property type="gene ID" value="L593_10665"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2199"/>
    <dbReference type="eggNOG" id="arCOG02546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="338"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="427"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="719" mass="74248" checksum="5D332E7E8CE3C13A" modified="2013-07-24" version="1">MDLNRRSVLRKASALSALAVGASGFATAADCSSAPAWDETVLYSTGDQVQHPDGDGIDALWEAELDSRNAEPSRSSSYWNYVGDCDGSGGGSNSAPTASFTTSISNPEPGENVSFDGSGSSDSDGSISSYSWDFGDGSSGSGQSVSHSYSSSGDYTVTLTVTDDDGATDSASQTVSVSSGSSNSAPTASFTVSPSSPTMGESATFDAADSSDSDGSISSYSWDFGDGSTATGQSVTHSYSSTGDYTVTLTVTDDDGATDSNATTVTVQSSSSGGACDGVSEWQSDVAYSGGDQVTHDGSLWTAEWWTKGTEPAESENVWTLEGACDGDGGGGGGNESPTASFTSSPYAPAPDETVTFDAADSSDADGSISSYSWDFGDGSSGSGQSVTHSYGSTGDYTVTLTVTDDDGATATDSTTVSVETDSGGGSGTSTFAPYNHMTTQPGTSLVDHYNQASNDAFTLAFVLSDGNGNAAWDGAPDQLVGEFGLASEIQDYQDTGGEVIISFGGAVGTMIAQDTTDIAKIKSEYEKVMDTYGVTHLDFDIESVNQDAVDRRNQALAELQSERSDLNVSYTLRCRTTGLTSHGTYVVESARDHGVDLQYVNIMTMNYGWVEPSASTVKDSANGTHSDLQEIFSGISSDEAWSMLGVTPMIGENNSGGAHHLDDAQEVATFVQNKGIGLVSFWSIDRDNGSCSTGTVSATCSGVQQSDYEFSGIYNDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W2</accession>
    <name>R4W8W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445878.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05175"/>
    <dbReference type="EnsemblBacteria" id="AGN00984">
        <property type="protein sequence ID" value="AGN00984"/>
        <property type="gene ID" value="L593_05175"/>
    </dbReference>
    <dbReference type="GeneID" id="16181249"/>
    <dbReference type="KEGG" id="sali:L593_05175"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_2"/>
    <dbReference type="OrthoDB" id="75437at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="158"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="389" mass="40804" checksum="59E3345F83EBBA84" modified="2013-07-24" version="1">MVSEERGFKLFYFILFASFSGYVMFRNVFLDEIGLTGTQMGIVGFLFPLCGMIAQPIWGLIADWKGASKPILYVSTIVAALAALLYPLAPFVGATFAAVLVATVVFATFRAPAVPIANALVLSSGMSYEGVRAYGSIAFGLAGLGFGFLIGITATEAVFYAYTVGTLLLALLLTRLPADDPEALGDDLDLESIRRLLSRQFFLLLGAAFFLGVMTPATAAFFSVYVRAIDQPDTITGFAWFIKTVAEAVAFVYVARRGGGSYRWLMAAAGVFYMSTYLLLATTGSIVVVVSSQVMLGLGYALFNLASVNLAHSISPAALKSTAQSLLMVGGVSAGRAIGELVTGVLVDAVGVQAMYGYVAVLGVLVVAFSLAISASTAADAERQAAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z6</accession>
    <name>R4W8Z6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05675"/>
    <dbReference type="EnsemblBacteria" id="AGN01084">
        <property type="protein sequence ID" value="AGN01084"/>
        <property type="gene ID" value="L593_05675"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1162"/>
    <dbReference type="eggNOG" id="arCOG00232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="26416" checksum="5FDBEB8633C2245D" modified="2013-07-24" version="1">MSTPVPRESFQAELEALQADVVGMGEHVLAQLDDALTALETADAELASDVIDGDDAVNERYLDLEARCVDLFALQQPVASDLRFVAAAFKILTDLERVGDLATNLGQYALAAGDGTVAADGAAGTASSAVDVPPESVTEIGRDAEAMLQDALDAFETENAEVCPEIAARDDELDVLCQHAGEDVVRQLLSAGTAATDTDPPTEWDVEQALDDVSRVLLTIRDLERVGDHAVNVAARTLYMVEHDPTLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W900</accession>
    <name>R4W900_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11365"/>
    <dbReference type="EnsemblBacteria" id="AGN02218">
        <property type="protein sequence ID" value="AGN02218"/>
        <property type="gene ID" value="L593_11365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2344"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="340" mass="36328" checksum="A82A3F898244B977" modified="2013-07-24" version="1">MTDDPGRPDGGSVELDPAPEPDDAAAVVADVTGEPIRVPDLGSVLVTGGGGFIGSHLVDALARHNDVRVLDRFDAGSEAGLPETVTTIEGDVRDRELLSEVVTDVDVIVHLAAQVSVEDSLDDPQRSSETNVAATLDVLELARREDARVVLASSAAIYGDPASIPIHETDPKRPESPYGVDKLAADNYARVYDARFDVPVVVLRYFNVYGADANAGVIRAFMERVDAGESLVIHGDGEQTRDFVHVDDVVRATIAAATTPHTGRAYNVGTGERVSIAELAHRVVDAVDDDLPIEYAPPRDGDVDHSLAAIDRARSWLGFEPRVDLETGIEATLSTAHEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W910</accession>
    <name>R4W910_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447142.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11525"/>
    <dbReference type="EnsemblBacteria" id="AGN02248">
        <property type="protein sequence ID" value="AGN02248"/>
        <property type="gene ID" value="L593_11525"/>
    </dbReference>
    <dbReference type="GeneID" id="16182568"/>
    <dbReference type="KEGG" id="sali:L593_11525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2376"/>
    <dbReference type="eggNOG" id="arCOG02601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114810_0_0_2"/>
    <dbReference type="OrthoDB" id="63240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="189" mass="21187" checksum="DE6CD41CCBE50592" modified="2013-07-24" version="1">MTGARQPVVLIVEDESDLADLYSAWLGDHCAVRTAYDGDEAVEAIDETVDVVLLDRRMPGLSGDEVLDAIGERGIESKVAMVTAVEPDFDIVEMGFDDYLVKPVSREDLVDTVEQLLLRGEYDDRIQQFFALASKKALLDSEKTEPELRASEEYARLVDRLAVIREESDEALLQLSENESYRQVLEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W915</accession>
    <name>R4W915_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447157.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11600"/>
    <dbReference type="EnsemblBacteria" id="AGN02263">
        <property type="protein sequence ID" value="AGN02263"/>
        <property type="gene ID" value="L593_11600"/>
    </dbReference>
    <dbReference type="GeneID" id="16181942"/>
    <dbReference type="KEGG" id="sali:L593_11600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2391"/>
    <dbReference type="eggNOG" id="arCOG04055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_4_0_2"/>
    <dbReference type="OrthoDB" id="125788at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="15169" checksum="D501BFA90CE845D9" modified="2013-07-24" version="1">MPYWLREHTADVAVEAEAQTLDGVFAAVADGLASTMCDSIPETGGDRFQLSVEAESREALLFDYLDQLIYERDVRSVLPVENDATVTEDGDRWAVDASARGIPFDDVEAREIKAVTYSDLALEETADGWRAYVVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W918</accession>
    <name>R4W918_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_11650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11650"/>
    <dbReference type="EnsemblBacteria" id="AGN02273">
        <property type="protein sequence ID" value="AGN02273"/>
        <property type="gene ID" value="L593_11650"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2401"/>
    <dbReference type="eggNOG" id="arCOG04471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065734_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014522">
        <property type="entry name" value="ArtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04125">
        <property type="entry name" value="exosort_PGF_TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="38183" checksum="EC18A0C4C65FDFAA" modified="2013-07-24" version="1">MVSVVGALEALSTYSWPLAWLSIVAFFAGAILEVSERRALAVRVAAAGWIAFGVFWLSKFHYFYVEFGSPLEGVLSLAALPLTWYAAYLLLSGRDSLLVVSRAVAAMGLIYLPVATIEPVKVFLIESVAQQSAWGMELLGYDVTLTEGANGYQGRFTFASRPEDSYTTYIVLACTGIGSISIFGGLTAAVRAPLRRKLKGFLAATGIIYVLNIFRNVFVGIAAPFGWFDGSVSETIATTMAGDVHTSFFIAHHLISQSLSVVALVAITLVVVRVVPEVVDPLEEVLFVITNTEYDLAEAIGQPRSGDGDSSALGSEDPDGADDPGSLGGADDSGGPGGVHGTRTDDVQPDGGTAGESQDDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W932</accession>
    <name>R4W932_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446048.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06025"/>
    <dbReference type="EnsemblBacteria" id="AGN01154">
        <property type="protein sequence ID" value="AGN01154"/>
        <property type="gene ID" value="L593_06025"/>
    </dbReference>
    <dbReference type="GeneID" id="16181600"/>
    <dbReference type="KEGG" id="sali:L593_06025"/>
    <dbReference type="eggNOG" id="arCOG01242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632565_0_0_2"/>
    <dbReference type="OrthoDB" id="39952at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="433" mass="48170" checksum="A520C655D0C8A970" modified="2013-07-24" version="1">MARTDDPDHRYLQARNRLRDASIPDRDKEASLEFLDALNPDTSTINFYSDDGVRETKSYGTLAAYAQALKRVAELAEQPLCEFENARAVNALFDDLGSGEHPDVKEGGYGKSTMAQWESAVSKFFEHHDSLGVDHEAIVIDRQEKSTVDERDMYTPDQVQQLREAVTNTRDRCILELLLNTGQRIRAVQTLRVKDVNTDAGVYYLNTADGGLKGADKNGKKRPLLGAKRAVYDWLKDHPTGEPDDYLITCLPTAARGTPGDKLSQSNIRDRLRGIADDAGVDKPPNPHNFRHYFVTACKRDYEMDESTIKHLIGHGQGSRIMETTYQHLSDNDHVEAAEVAAGLREPDAGSPLTPKICPTCSESLAPEAKACPGCGTVFAPDAQATQAQIEEDVKADYRETDPSDEETMERLETLDELLDDPEVKEALFERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W945</accession>
    <name>R4W945_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446073.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06150"/>
    <dbReference type="EnsemblBacteria" id="AGN01179">
        <property type="protein sequence ID" value="AGN01179"/>
        <property type="gene ID" value="L593_06150"/>
    </dbReference>
    <dbReference type="GeneID" id="16181711"/>
    <dbReference type="KEGG" id="sali:L593_06150"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="184" mass="19755" checksum="4EECB6D4303AA30B" modified="2013-07-24" version="1">MTVTPEDQGVRIRPVERADLLAVHRIERAAFSTPWPFEAFERFVDAPGFLVAVEEPEGAVAASAEGGEATGVGDGAADREGVIGDGGVIGYVVAEVTPNHGRAFGHVKDLAVHPEHRRRGIASTLLERALVTLAGEGATSVKLEVREDNEAAQALYREFGFAPMRRRAGYYEDGTDALVMAREL</sequence>
</entry>
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    <accession>R4W957</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="gene ID" value="L593_12320"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2505103_0_0_2"/>
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            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9135" checksum="A81473BA5946AD15" modified="2013-07-24" version="1">MLVPALAALVLAVSLTCVARRLDHEPGPPRSHVHETDDGERGRPFEALAEGAAADRGRCRDCGEVIESRVFRLCQSCASRPIPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W958</accession>
    <name>R4W958_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="15917" checksum="6C34E9F9E01A82BD" modified="2013-07-24" version="1">MALEFFGSYHAWLAMAIGTHALVGYVLGAATFSRPTVGALGAVLADVDLLFPGPDGAPLGHRGMTHSALALGIAVAIASYWGRDVAGSVGIGYVSQLAIDATTPKGIPIVFPLSTENVGVAWNLHSKDATILLLGLCAVALILERHLLRSRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W994</accession>
    <name>R4W994_9EURY</name>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01274">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="137"/>
        </location>
    </feature>
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        <location>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="194"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="47733" checksum="2355741DD2F6419F" modified="2013-07-24" version="1">MAISPDSSVPADDDSPGSGPTTPDGGEPEGATRGATSDAAERGVLGTIGSIVSDHVVHIGIVFLFAIYPLAYTQLMALPFGEELNIILPRTRTMIVVLYFGLFAMSFDFISGYTGYLSFGHSMFYGIGAYLVVLTANGKVPLVGQGTPLLLLLVVGGLLAAAIALLVGAVSFRLSGVYFAMITLGFAEVAHVFIRNWDYVGSNPRDGAGFVEAFSLGIPGVYSVKLGQIVGTEYTDVFGTAFDLSKADVSFYAIGVVVLLCYFAMQRVIHSPYGKVMIAIRENEERARAVGYNTFYYKMGAFAMSGFFAAIAGGLFAGYQRSVAPENTFDLFVTADALLAAIIGGFGTLAGALYGILFQDVLEGILSTEGHGIAPYLRRTLSESTMDSAVGDGIDLLLDGRAELYIGIVFILFVLYVPEGILGTLRSRLGGTVAEKLPERLQRYRGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B4</accession>
    <name>R4W9B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447427.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02533">
        <property type="protein sequence ID" value="AGN02533"/>
        <property type="gene ID" value="L593_12970"/>
    </dbReference>
    <dbReference type="GeneID" id="16180273"/>
    <dbReference type="KEGG" id="sali:L593_12970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2659"/>
    <dbReference type="eggNOG" id="arCOG00373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330820_0_0_2"/>
    <dbReference type="OrthoDB" id="44989at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="866" mass="88845" checksum="108612E9061156A9" modified="2013-07-24" version="1">MPAGLDVGAARIVAATADGTDGARNAALAVDRSDYVEDFLEGADTPSIETDDGIVALGDAAPEVATIANDSPTRLLAADSTLPIDDVPAAVEALLRGLVGEGSGPLRYAPPSGVDAGPIEEAASALGYDPAPVEPGLAVLYDALDAPPTGLGVVVDGTRTIATLVVAGVPVSRSELSRGGDWIDQEIASATGNDPEEVAELRANADLEDPNSGALALRYDTLLSNLAIAIAEESPAVDEPVPIVVAGAAAPMGIDGRLEDALDDVDLPFAVASIDRAEDPEFAAARGALVAAEDGSQIETDGAEADPATAGFATGLADESAATIALASGSGTAASESGTAASGGADAAQKGGADAPAPATAAGTDASDPGASAASGSPELDAEREELRERLQRLEDRIGIDDEQPLDEDVAALAEEVATLVALREDVSALEAAVEDESDAGASGVDVEALQTELETVADSLESRADDLEEQVAATPDAERVEDLEARLEALPPIADLADMAERVGAIDAEELSEVADSLDEQSASAEAVEERTDALADDVDGLHDDLDGLQEDVDDLHENLDALEDVSTDLDALSDDVDAVESAVESLEDDVVDEATIDAIRERVDVVETTVEDVEADFEDAASTTDLEDVEERLEDADEELDGARADIENVESRVGDLEGEVPDPDLVDALSVDLEALRGRVEELEASVEDRFQDTQDRLQTVEDDLDAIDANAADAEELATIESDVATLESTVEDAEADRAELDGAFDDLRADHGAAIEDLEADVADLETAVEEFPDDSVGITQHQNAITRVESRMDEIEKTIAEVDANAESGPGRAAILVLGLGLAAVGGLGAGLATLSDQVALAGGFVGVPLVAVVVAWYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G1</accession>
    <name>R4W9G1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein uspa-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447527.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13470"/>
    <dbReference type="EnsemblBacteria" id="AGN02633">
        <property type="protein sequence ID" value="AGN02633"/>
        <property type="gene ID" value="L593_13470"/>
    </dbReference>
    <dbReference type="GeneID" id="16179867"/>
    <dbReference type="KEGG" id="sali:L593_13470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2755"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="18056" checksum="2BB83816BCAD531B" modified="2013-07-24" version="1">MYERILVPTDGSAGVERAVEHAIDLATTHGATIHAVYVVNTASYGGIPMETSWDGIRDVLSDEGQAALERVRTLAEAAEVEAEAAVLDGSPSRQIVNYAEEADCDLIVMGTHGRGGLDRLLLGSVAERVVRSSEIPVLTVRVGEPPDAEERTASEASSSTEESVEPAEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J8</accession>
    <name>R4W9J8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="2">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_13870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447607.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13870"/>
    <dbReference type="EnsemblBacteria" id="AGN02713">
        <property type="protein sequence ID" value="AGN02713"/>
        <property type="gene ID" value="L593_13870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180899"/>
    <dbReference type="KEGG" id="sali:L593_13870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2838"/>
    <dbReference type="eggNOG" id="arCOG04421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_1_0_2"/>
    <dbReference type="OrthoDB" id="47738at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="7">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="37738" checksum="51470EBEA1BAF3E5" modified="2013-07-24" version="1">MTSVKEFRIEEPATAEELGHGVFEFTDDYSVFDWGKMPDPIPDKGASLCTMGAFNFELLANESIRTHYRGVLPADGGKPVGLDVVDEPPTEMAIALSQRPDLPREGTDYDYDVYHEAAGENYVVPLEIVFRNSVPIGSSLRSRTDPADHGLDFETWPDEPVDLDDPIVEFSTKYEESDRYLDRTEADAIAGKAPIEDLDGLAREVNDLVTRWAATQGFAHEDGKIEVVYHQGNLLVADVVGTFDENRFAYDGQQLSKEVLRQYHKRTQPKWVEAVDVAKTEAKAQGVADWKGLCDAAPAPLDDDVLQVARDMYAAGANAYVGEQFFDAPSIEDAVAAIRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K3</accession>
    <name>R4W9K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447622.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13945"/>
    <dbReference type="EnsemblBacteria" id="AGN02728">
        <property type="protein sequence ID" value="AGN02728"/>
        <property type="gene ID" value="L593_13945"/>
    </dbReference>
    <dbReference type="GeneID" id="16181238"/>
    <dbReference type="KEGG" id="sali:L593_13945"/>
    <dbReference type="eggNOG" id="arCOG00457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_1_1_2"/>
    <dbReference type="OrthoDB" id="83005at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="22458" checksum="697E752F85AFDFBB" modified="2013-07-24" version="1">MQIAILGGTGALGGGLALRLAHDTDHELSIGSRDPERAADAAASYRETLADRGVNSRIESGANPDAAAGAAVVVAAVPATYVADTIETVADRLHEDAIVVSPAVGIDAHAHGFDAAQPAPGSVTATAADAAPASNPVVGAFHTLAAGRLSDLDAALEIDALVVGDDPDARDRIAALVEEIEGLRALDVGPLANAHGVECLTALQLTLMRQNSALEDVGVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N0</accession>
    <name>R4W9N0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">alaS</name>
        <name evidence="14" type="ORF">L593_08520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446543.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08520"/>
    <dbReference type="EnsemblBacteria" id="AGN01649">
        <property type="protein sequence ID" value="AGN01649"/>
        <property type="gene ID" value="L593_08520"/>
    </dbReference>
    <dbReference type="GeneID" id="16181753"/>
    <dbReference type="KEGG" id="sali:L593_08520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1744"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OrthoDB" id="7896at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="60"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="926" mass="102217" checksum="B4F4D9D6F5ECD06D" modified="2013-07-24" version="1">MSDLEEEYRLDYFAEEDFVRRECVECGDHFWTRDHDRETCGEPPCETYTFIDDPGFAEEYTLEEMREAFLSFFEEHGHERIDPYPVAANRWRDDVLLTQASIYDFQPLVTSGETPPPANPLCISQPCIRMQDIDNVGTTGRHTMAFEMMAHHAFNAREDIEDAEQYAYEGEVYWKDRTVELCEEFFASLGADRERITYIEDPWVGGGNAGPAIEVIYEGAELATLVFMSMTQDPDGEYELKDGNRYAPMDTYVVDTGYGLERWTWVSQGTPTVYEAIYPDQIAFLKDNAGIELTDEEAQIVHDAAALAGNMDIDEAEDLEAARDEIAAEVGVDVADLEALMEPLETIYAIADHCRTLAYMFGDEIVPSNVGTGYLARMVLRRTKRLVDEVGVDAPLDELVDMQAERLGYENRDHIRDVVRTEVEKYRETLERGRRRVEDLAAEHAEAGEPIPTEELVELYDSHGIQPDMVEDIAEAQGADVDVPEDFYGQVAARHDQETGGISAADADERFADLPATEKLYYDDQQGTEFEAVVLDVFERQEGYDVVLDQTMFYPEGGGQPPDHGTLASDDRTVDVTDVQIEDGVIRHRTDGELDKGDMVRGKIDVDRRRQLMRNHTATHAVIHAARQVLGDHLRQAGAQKGVDSSRIDVAHYARISREEVKRIESVANDLVMANVPVSQEWLHRNDAEAEYGFDLYQGGVPPGEEIRIVTVDADVQACGGTHVARTGDVGAIKIRSTERVQDGVERLIFSAGTAAIEATQETEDALYETADALDVDPQAAPETAARFFEEWKERGKRIEELQEELAAARAAGGDDDAVEIEVGDATAVIRRIDADMDELRATANALVEDGQIAVLGSGAEGAQFVVGVPDGSAVNAGEVVSQLAGRVGGGGGGPPDFAQGGGPDGEKLDDALADAPDILQAVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S8</accession>
    <name>R4W9S8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranf_PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446638.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08995"/>
    <dbReference type="EnsemblBacteria" id="AGN01744">
        <property type="protein sequence ID" value="AGN01744"/>
        <property type="gene ID" value="L593_08995"/>
    </dbReference>
    <dbReference type="GeneID" id="16182728"/>
    <dbReference type="KEGG" id="sali:L593_08995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1845"/>
    <dbReference type="eggNOG" id="arCOG02286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135996_0_0_2"/>
    <dbReference type="OrthoDB" id="78955at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranf_PUA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="22491" checksum="EA8F0F2406C62FA2" modified="2013-07-24" version="1">MSDDETYLGLGEGEAAPDEHDTTSDASDRTETDLDENVSHRFDRLAPTDAERTVAGRPSREAVLQWWDDRFGIPPATFAEHTLWEKGNGKLWVLAGDAADPSDVEAVGMTFLRTRQEHWKPTTDAVQRFGDAATQNVIELKREEARRFAAGEDQSIDRWDGDWGYLIAAHELAGDRAILGVGLYVHGELRSMVPKGRRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U8</accession>
    <name>R4W9U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446723.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01829">
        <property type="protein sequence ID" value="AGN01829"/>
        <property type="gene ID" value="L593_09420"/>
    </dbReference>
    <dbReference type="GeneID" id="16182733"/>
    <dbReference type="KEGG" id="sali:L593_09420"/>
    <dbReference type="eggNOG" id="arCOG10706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490381_0_0_2"/>
    <dbReference type="OrthoDB" id="125592at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9951" checksum="8306D79BF08C4290" modified="2013-07-24" version="1">MAPPTIQSIDESDEYLHVRYRDPDEFEEIRTPDWAAEVAESVVEGGEVRMGRDESQDEWRVQSVLVPTPSDTQEAESAASEIVEKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V3</accession>
    <name>R4W9V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transport system permease protein (Probable substrate iron)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_09545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446748.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09545"/>
    <dbReference type="EnsemblBacteria" id="AGN01854">
        <property type="protein sequence ID" value="AGN01854"/>
        <property type="gene ID" value="L593_09545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180381"/>
    <dbReference type="KEGG" id="sali:L593_09545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1965"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_0_0_2"/>
    <dbReference type="OrthoDB" id="32131at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="341"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="541" mass="58531" checksum="D47E552045035EDA" modified="2013-07-24" version="1">MSVRERLQVVRQRIGGSGDAGERPPRSLLAISGAIALVVVFPLVWLLVTAAEIDPGEAWDLATSEETLTVLKNSLLLMGGVTAGSVLLGVPLAYLTVRTDLPFRRFWTIVSALPLVIPSYVGAFTVVSAFGPRGRFQDMLEPLGVEQIPEIYGLPGAIVVITLYTYPYVYLTTRAALLSFDARLVEAARTLNHGKLAAFWRVTLPQIRPAIAAGALLAALYAISDFGTPAIMRLPVFTREIYVEFGQLGQAPEAVLSLQLLAIVALVLVIERWIVPDASASESEATRDRPVSLGRWRWVAMGFPALVAGLALLVPLWILYLWLSSSATARRPSLAFEWSMATNSVKVAAAAALIAAIAALPIGYLSAHHDSRLAAVFERGTYLGFAVPGVVLGLSLVYLGTRLVPALYFTLPLLIFGYVVRFLPQAVGSIRSTTLQVDPRLVEAARTLGDSPFRAFRRVTLPQIVPGIVAGAALVFLTTMKELPVTLMLKPNEFETIATQIWRAQDSHFYQYAVVPALLLMVISGFSMIVLLASEGGREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W6</accession>
    <name>R4W9W6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16S RNA G1207 methylase RsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446813.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09870"/>
    <dbReference type="EnsemblBacteria" id="AGN01919">
        <property type="protein sequence ID" value="AGN01919"/>
        <property type="gene ID" value="L593_09870"/>
    </dbReference>
    <dbReference type="GeneID" id="16182840"/>
    <dbReference type="KEGG" id="sali:L593_09870"/>
    <dbReference type="eggNOG" id="arCOG00110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049581_3_0_2"/>
    <dbReference type="OrthoDB" id="50061at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="229"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="397" mass="41329" checksum="E89974A00FAA4B17" modified="2013-07-24" version="1">MATRLRTLALEARTEGGPDRFEFTTADGVCSADAIRTAELLLAEVLWDRDPGNLLVPEANYGVVGTLLADVAASVTMTESSARATELCRRNARENGADAHVALLAELDSLGSGDGATEPDPNGPPFDVVAYAPKPYTPIAVGRQRIADAFGLLAPGGTCIVAAEPTTGLDRYRETLEVIGNCVGTVCERDGVAVIEARRQGAADPVEALDRRPLVEPRPLTPTVDGVDLELVSGPGLFAAGGLDHGTRLLLETLDVADGDRLLDVCCGYGPIGAFAAATADCSVVLTDDDRVATQCAECSLQRTDLAAGSETTVVTGNCTEAVADRTFDLVATNPPTHAGSGVLSELFAGIRDVLAPDGACLFVRHEALDLSGHLRGFDSVETVAAGEEHVVRRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X3</accession>
    <name>R4W9X3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446848.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10045"/>
    <dbReference type="EnsemblBacteria" id="AGN01954">
        <property type="protein sequence ID" value="AGN01954"/>
        <property type="gene ID" value="L593_10045"/>
    </dbReference>
    <dbReference type="GeneID" id="16182561"/>
    <dbReference type="KEGG" id="sali:L593_10045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2071"/>
    <dbReference type="eggNOG" id="arCOG01121">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153623_0_0_2"/>
    <dbReference type="OrthoDB" id="100195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="14812" checksum="4742E255821A103C" modified="2013-07-24" version="1">MSEEPRDSERDRGGDGDAPDASDGPQWRSRLEAQGELTPDVVEDVLAAHGDRGSRAIDAVGEGRVKQYQDFTVVVGNSDEYVVEDGACTCKDATYNLDPEDPRALCWHALAAEIARAVGALDHHDMYYSEVRDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z4</accession>
    <name>R4W9Z4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">L593_10570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446953.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10570"/>
    <dbReference type="EnsemblBacteria" id="AGN02059">
        <property type="protein sequence ID" value="AGN02059"/>
        <property type="gene ID" value="L593_10570"/>
    </dbReference>
    <dbReference type="GeneID" id="16180540"/>
    <dbReference type="KEGG" id="sali:L593_10570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2179"/>
    <dbReference type="eggNOG" id="arCOG01337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_2"/>
    <dbReference type="OrthoDB" id="72275at2157"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41056" checksum="56C62FB835F54F21" modified="2013-07-24" version="1">MKLHEFQAKELFADAGIPTPDSQLAATPEEVVAAAEEIGYPVAVKAQVQVGGRGKAGGIELVEDAEEAQAAAESIIGMDLKGIHVDRVLVEAAVDFVNELYVGVTMDRGEGKPVAMVSTRGGVNIEEVAEEDPDAIVREHVDPAFGMHPYQARKAAFEAGVDRDIAIDVAGVLQTLYQLWDDNDGADAEINPLMVTSDDEVVAADAVFNVDEDALFRQPKIAEYEEDTKSDDPLEQKADEYDFDYVRLDGNVGIIGNGAGLVMTTLDLVDHYGGEPANFLDVGGGAKAERIANALDMVFSDDNVDAVVFNIFGGITRGDEVARGINEALGQFDEIPKPVVVRLAGTNWEEGMEILDESLVTVEQTLEDAVQRSVEYAQEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z8</accession>
    <name>R4W9Z8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_10670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-arginine = L-ornithine + urea</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446973.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10670"/>
    <dbReference type="EnsemblBacteria" id="AGN02079">
        <property type="protein sequence ID" value="AGN02079"/>
        <property type="gene ID" value="L593_10670"/>
    </dbReference>
    <dbReference type="GeneID" id="16181404"/>
    <dbReference type="KEGG" id="sali:L593_10670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2200"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_2_2"/>
    <dbReference type="OrthoDB" id="56052at2157"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="302" mass="31710" checksum="9FA56EFB0772A6E2" modified="2013-07-24" version="1">MDRPVRILGVPTDYGANRRGVDMGPSAIRYAGLEAAVRRVADEVLDDGDMEVVRAESTDPDRAPMDGRAKFLAEIEDVADRLADRVAAACEAGTLPLVLGGDHSIAIGSMAGAARDADLGVLWFDAHGDFNTPSTTPSGNVHGMPLAAALGRDEFAEMEWAQAPGLAPERVAIVGVRNLDPPERQAIRDSPVTAFSMSDIDEHGIVDVVEAAIAAASDGADGLHVSLDLDWLDPKEAPGVGTPERGGVTYREAHAALEAVAAASTRTRSLEVVEVNPVLDQHNETAELACELVASALGERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA12</accession>
    <name>R4WA12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447043.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11020"/>
    <dbReference type="EnsemblBacteria" id="AGN02149">
        <property type="protein sequence ID" value="AGN02149"/>
        <property type="gene ID" value="L593_11020"/>
    </dbReference>
    <dbReference type="GeneID" id="16181394"/>
    <dbReference type="KEGG" id="sali:L593_11020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2272"/>
    <dbReference type="HOGENOM" id="CLU_2893418_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6547" checksum="E3B1A680A695A841" modified="2013-07-24" version="1">MVDPLILGVALFGLTILPFGTYLLLEWSKSDANRSDGRAVPSSTTQNAPSRTIPGSNGRDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA30</accession>
    <name>R4WA30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447133.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11480"/>
    <dbReference type="EnsemblBacteria" id="AGN02239">
        <property type="protein sequence ID" value="AGN02239"/>
        <property type="gene ID" value="L593_11480"/>
    </dbReference>
    <dbReference type="GeneID" id="16181495"/>
    <dbReference type="KEGG" id="sali:L593_11480"/>
    <dbReference type="eggNOG" id="arCOG02503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477038_0_0_2"/>
    <dbReference type="OrthoDB" id="102661at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_peptide_camelysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="582" mass="61044" checksum="A6CD794C4EA485EA" modified="2013-07-24" version="1">MTREPTIELSRRSLLGGLGGIGVASAGAALGTSAYFTDDEAFEGNSIAAGSLDLKVDWEEHYYDGSSGRDLVSYSDPGGGAVGFPDPDDPQVWIAEDDVAAFMNATAVEAFPDPDDDGSQETSTDSFEYVPCEMGADVPADLDPAGFRTDNDDTRAGDGPAPLIDLQDVKPGDFGELTLSFHLCDNPGYVWLRAANVESAENGQTEPEAAVDQSSGGELADHVQTVWWYDSRGDNVLQTGCDETLYLIDSVGGTGTASELFEVDLTGGNAELTSIYVAGGGNFDQTDAIAATPDGDEVVFYDKESTHLGTYDVAANSFTDDGPVSGDPGGVVLAGYSPSGALWAASTNTDELYTVDRSGPSVTARGDTGIDLEGADLVFASDGTMYIWTAASADQGLYRVSDPANDATAVPVDASNVGGLDVRITGLAIRNGGTGNLVASDRDNDEIVVVERTDGTIQDRYPMTLGGEAYEYDYGDMSAGRYCGEVFRRGTLRADLDALASGTGIPLDGNRATPFDELSEDPGSPDRECFTPELTHYVGFAWWLPPDVGNVVQSDSIGFDLGFYAEQCRHNDGSGAPADGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA97</accession>
    <name>R4WA97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447468.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13175"/>
    <dbReference type="EnsemblBacteria" id="AGN02574">
        <property type="protein sequence ID" value="AGN02574"/>
        <property type="gene ID" value="L593_13175"/>
    </dbReference>
    <dbReference type="GeneID" id="16180444"/>
    <dbReference type="KEGG" id="sali:L593_13175"/>
    <dbReference type="eggNOG" id="arCOG04140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179754_1_0_2"/>
    <dbReference type="OrthoDB" id="126791at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240">
        <property type="entry name" value="PTHR42240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="SSF160363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10396" checksum="97F267F0C2B37553" modified="2013-07-24" version="1">MADVRRIVLDVLIPHDPSLLEFTDRIAEVDGVGGATATVVELDEDVQNLTVAVEGQRLEYEAIEATIEDLGGTIHSVDQVACGERVVERRPTPQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB7</accession>
    <name>R4WAB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447568.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13675"/>
    <dbReference type="EnsemblBacteria" id="AGN02674">
        <property type="protein sequence ID" value="AGN02674"/>
        <property type="gene ID" value="L593_13675"/>
    </dbReference>
    <dbReference type="GeneID" id="16180772"/>
    <dbReference type="KEGG" id="sali:L593_13675"/>
    <dbReference type="eggNOG" id="ENOG502N5JP">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1976631_0_0_2"/>
    <dbReference type="OrthoDB" id="131477at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13245" checksum="90CA8FDFBEBB9894" modified="2013-07-24" version="1">MAHANRSMVAAFGQLNVLTTLFMLVFAVLTFVVTGLASEAITFLEAHPAITVVASLVCLVVIFASSNTRSPEYYHWAEMGIVFASIGLMIASAFLAEFAAFVATYQPVTGGIISLVALVAAAITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE3</accession>
    <name>R4WAE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447698.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14325"/>
    <dbReference type="EnsemblBacteria" id="AGN02804">
        <property type="protein sequence ID" value="AGN02804"/>
        <property type="gene ID" value="L593_14325"/>
    </dbReference>
    <dbReference type="GeneID" id="16181186"/>
    <dbReference type="KEGG" id="sali:L593_14325"/>
    <dbReference type="eggNOG" id="arCOG01585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_4_0_2"/>
    <dbReference type="OrthoDB" id="81422at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="21118" checksum="CD1FFF61892163D1" modified="2013-07-24" version="1">MPQLDDTDLEILRLLVANARRPYSEIADKVGVSPPTVSDRIDRLEQLGVIRRFTLDIDRSTIDAGIQVLIDVDTEPGATETVAADLADQNVVEHVYATADGSVVAHATVPEDSVHDVLAESVAMDDVKSIDVRLLTEEEWTPEVSGTAFALNCAVCGDEVTSQGESARIDGELVTFCSATCREAYAEEEQLAAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VRZ0</accession>
    <name>R4VRZ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroA'</name>
        <name evidence="3" type="ORF">L593_00075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444864.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00075"/>
    <dbReference type="EnsemblBacteria" id="AGM99969">
        <property type="protein sequence ID" value="AGM99969"/>
        <property type="gene ID" value="L593_00075"/>
    </dbReference>
    <dbReference type="GeneID" id="16181722"/>
    <dbReference type="KEGG" id="sali:L593_00075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.15"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_0_2"/>
    <dbReference type="OrthoDB" id="57391at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="27414" checksum="5135E6266A3E6809" modified="2013-07-24" version="1">MSTGTTARLSRIGTDGTYLIVPMDHGITIGAVQGLKDIESTIDAITTGGADAVLTQKGIAPRVHPNKNGAGYIVHLNGSTAIGPDEAEKRLTGTVKEAIRVGADAVSFHINVGSQYEPDQLTELADVTSEAAEYGMPVLAMAYARGPGIDEHDAESLGHAVRLAEELGADVVKTSYSGDAESFQHVVESTRLPVVIAGGSRGSDRETIEMVRGTIDAGGSGVSMGRSIFQHEDPEAITRAVAAVLHDDASVDEALKRAGLAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS39</accession>
    <name>R4VS39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444929.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00400"/>
    <dbReference type="EnsemblBacteria" id="AGN00035">
        <property type="protein sequence ID" value="AGN00035"/>
        <property type="gene ID" value="L593_00400"/>
    </dbReference>
    <dbReference type="GeneID" id="16180184"/>
    <dbReference type="KEGG" id="sali:L593_00400"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="25993" checksum="F5E4D349989DE62F" modified="2013-07-24" version="1">MDGIHGSTAIVTGGGSGIGREAALRFGDEGANVVVADVDVEGSEETVERIRDAGGEATVVATDVSDPDEVEAMVDTAVDTYGSLDFAFNNAGIEGESEPAGEHPLDNWEQVIDVNLKGVFLAMRYEIPAMLESGGGSIVNTSSIAGLVAFPNLSPYVASKHGVIGLTKTAAVEYSGEGIRVNAISPGVIDTPMVARSQEDDPETMEATKAATPIGRLGQPEEIGDAAVWLCSEDASFVTGETLTIDGGYVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS59</accession>
    <name>R4VS59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444949.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00500"/>
    <dbReference type="EnsemblBacteria" id="AGN00055">
        <property type="protein sequence ID" value="AGN00055"/>
        <property type="gene ID" value="L593_00500"/>
    </dbReference>
    <dbReference type="GeneID" id="16181642"/>
    <dbReference type="KEGG" id="sali:L593_00500"/>
    <dbReference type="eggNOG" id="arCOG06219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527481_0_0_2"/>
    <dbReference type="OrthoDB" id="42385at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="503" mass="53105" checksum="45710D98477A7817" modified="2013-07-24" version="1">MSGSRPGFRPSGVGVALLAFSVTRLLVAQTATTEAGTFVAASLFPLSAGLGLTLFGIAISVGGVSRGYARSVWRWTVLGTFAMLLVVVASGLHVILLGDRLGALWSDSGVLVANVLLGGAILGAFVGDRSARHWNTNERLVQYAERSMLVNRLLRHEIRNVLAIVNGYVATSDNDQEETTRAIRESTEEIEQTIEHAGEFAATTGEIFAVEIGDAIESVLDVLPEDADVSVAGSIPDGVLVRADDRLDLLVAELLENALQHAGPDPSVDLDVEVGHRTVELTVTDDGPGLPEPAESVLASRSLPEYDDPSLGYGLQMVRLLVEQYDGAIEADYADGTALTVTLQRTRERSTPALARGVPTVDLHRAGFAAVAAGIVMGLFVDQVAGLMPVVGSLYGVSSPVLGWVAHIFHSVLFGILFAAGCMLPRIREVAASQRGLFALGIGWGLLLWVFAAGIVMPIWLLAVGTSATIPHFSAIDLVAHVLWGAILGGLYARLPAETLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSV4</accession>
    <name>R4VSV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445159.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01560"/>
    <dbReference type="EnsemblBacteria" id="AGN00265">
        <property type="protein sequence ID" value="AGN00265"/>
        <property type="gene ID" value="L593_01560"/>
    </dbReference>
    <dbReference type="GeneID" id="16179862"/>
    <dbReference type="KEGG" id="sali:L593_01560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.317"/>
    <dbReference type="eggNOG" id="arCOG02284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015706_1_0_2"/>
    <dbReference type="OrthoDB" id="4397at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014441">
        <property type="entry name" value="UCP006425_b-propeller"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006425">
        <property type="entry name" value="UCP006425_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="654" mass="70613" checksum="8278BDEC488BF447" modified="2013-07-24" version="1">MSTSNAGTILLVAVVLGVAVGLGGAVVLTDAGDSDGAPSSTDPFEDGSVGSVETFDSAAEYREYIQRGSSQSVHNFWGGPLVLTDVAVERDDAGGDGGMETAPTGDSSAESGTDGGGSTDDRRTSGTNVQVQGIDEPDIVKTDGEWVYYAGSNGRYWEQSERTQVLNASDTAHPARSGAIPAGGQLLRSGDTLVAIESDTLYGIDVSDPEDPEEQWRVPLNHSVQTARLANGSVYLVLSDQPTADGPCPIEPLGDGRASIPCTEVYHPGGGAGGDTTYTALSLDPESGDVQDRVSFVGSAQNTVVYVSQGSIYLTFEDSPTRSETRLAFFQGPGSEHLDQQAKDRLEEIASYDLSPQAASIEIETTIQRRIQRLPEDEREQAMREIEEDYQTYVSEHKRELVRTGIVRVGIDDSSLAVEETGEVPGRVHGQFSLSERNGYLHVATSVTPMGGQWENDLYTLDSSLEIEDSVTGMGTDQRIYSVRYVDDRAYLVTFRQVDPLHVIDISDPTDLELQGELQLPGYSDYLHPIGDDQLLGIGEEDGQVKATLFDVGDPNDPVVADDIHFEDYGTAISQTHHAFLIDQRHGVFFLPGSQGGHVVNYENGSLDRVTTVETDGPALRARYIGDHLYVFGTEEVVVVNENTWEETERIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTK3</accession>
    <name>R4VTK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445459.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03070"/>
    <dbReference type="EnsemblBacteria" id="AGN00565">
        <property type="protein sequence ID" value="AGN00565"/>
        <property type="gene ID" value="L593_03070"/>
    </dbReference>
    <dbReference type="GeneID" id="58789331"/>
    <dbReference type="KEGG" id="sali:L593_03070"/>
    <dbReference type="eggNOG" id="arCOG09132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619144_0_0_2"/>
    <dbReference type="OrthoDB" id="110213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="45687" checksum="D4D09FE8798EC63A" modified="2013-07-24" version="1">MLDRRSVLRRAGGALTTATLASSAGCFFTVGSSSSSASSTFLTPLPNPLPGVAPNFHCAYGYDPAAIQRTLGGTDAMPSLAGQFVTVVDQLRGTAVEDVDRLSGQTVRQVGHPGSDLGVVASDGTDLVAEGSIDVDGAVDWLATREQLENLGRSRGYRRFGNGGATVEGFAVDEDAMTFGNRRATSLSAADVTAAAIEGLQSDAAAAAETTPTLAATVDELPSGSATIATAFDLVAERPDTGSEAYDGTASSLLAAGLSANVGDETTAITRVLRYRRGRVASVDSVRAAVDEAVAAGYLTDVEWTVSASGRSVRIEGSVSTATLADAPELLRRGVPVPAYDGLPTPVDPRELGRDAPPRVAWELSMLDDGRVAVVHGGGPDVEGITVAYTVDGERVREDWQGPVSSEDRFETSEAPDAGSVVDVVWARGTANETILIRAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTS6</accession>
    <name>R4VTS6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">L593_03420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445529.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03420"/>
    <dbReference type="EnsemblBacteria" id="AGN00635">
        <property type="protein sequence ID" value="AGN00635"/>
        <property type="gene ID" value="L593_03420"/>
    </dbReference>
    <dbReference type="GeneID" id="16180537"/>
    <dbReference type="KEGG" id="sali:L593_03420"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.692"/>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OrthoDB" id="98221at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="14283" checksum="0BF2C75F72DAA2B8" modified="2013-07-24" version="1">MAREQKEVRDLQEGNYVMIDDAACKINSYSTAKPGKHGSAKARIEGVGVFDGQKRSLSQPVDAKVWVPIIERKQGQVVSVESEDVAQVMDLETYETITIRVPGDDELSPDQQIEYLEMDEQRKIVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU38</accession>
    <name>R4VU38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="7" type="ORF">L593_03770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445599.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03770"/>
    <dbReference type="EnsemblBacteria" id="AGN00705">
        <property type="protein sequence ID" value="AGN00705"/>
        <property type="gene ID" value="L593_03770"/>
    </dbReference>
    <dbReference type="GeneID" id="16180683"/>
    <dbReference type="KEGG" id="sali:L593_03770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.765"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OrthoDB" id="85023at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="22402" checksum="8CF71003CFF9A585" modified="2013-07-24" version="1">MARSFYSHIRDAWRDPGDGKLAELQWQRKQEWRDQGAIVRVDRPTRLDRARELGYKAKQGVVVARVAVRKGTARKERFTAGRRSKRQGVNRIGRRKNIQRIAEERSSRAFPNLRVLNSYWVGEDGSQKWHEVILLDPEHPAIENDDDLNWICEDSQSGRAFRGKTSAGQSNRGLNNRGKGAESNRPSASEGSDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUQ1</accession>
    <name>R4VUQ1_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444885.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00180"/>
    <dbReference type="EnsemblBacteria" id="AGM99990">
        <property type="protein sequence ID" value="AGM99990"/>
        <property type="gene ID" value="L593_00180"/>
    </dbReference>
    <dbReference type="GeneID" id="16181143"/>
    <dbReference type="KEGG" id="sali:L593_00180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.36"/>
    <dbReference type="eggNOG" id="arCOG04732">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029030_1_0_2"/>
    <dbReference type="OrthoDB" id="13478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="518" mass="57665" checksum="00A4CF7BEF03D2B2" modified="2013-07-24" version="1">MADVDLVDDVAALRSIDHERFHQQVETERKRLKAAIDDGIFDNPQGSIGLEYEFYAVAEPDAAEGRTGATEAGSLMRVPRRLLTMIGFEKELGLHNAEMSTSPQPLNRYGLTSQEAEVQSRLAAAQDVTQTEGMRLVSDGLWTIPPHGETARDYLTAAAIENDVAIATNMSDAVRYHAMANSEAADVGLVVDAPHVSLSAETVMPESLITSIQPHYQVPQARDLPLYFRYALRIAAPLLALCANSPFFPPDCYEDGTTIEDAIEDGWDEHRISVFETVLNAPSETTGKVRFPREIESAKQTVDRVAEDDLLIPIDVEETGRYDDEFAHFRHKHGSFWRWIRPVFDGPSKSAANARIEFRPIAGQPTVHDSISVLAAFAGLMVQLPRIDHPVDELDWETAYDNFYAAMRQGIDANLLWITEDGHETRRIDAIYGDLLDQAEAGLRAKDVPSHQIDSYLRPLRKRVELRTTPATWKRDRARAAADAGGDLAEAIGTAQRAYLDRQRGTLLEGSFVDWVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUV2</accession>
    <name>R4VUV2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
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            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00455"/>
    <dbReference type="EnsemblBacteria" id="AGN00046">
        <property type="protein sequence ID" value="AGN00046"/>
        <property type="gene ID" value="L593_00455"/>
    </dbReference>
    <dbReference type="GeneID" id="16181502"/>
    <dbReference type="KEGG" id="sali:L593_00455"/>
    <dbReference type="eggNOG" id="arCOG04581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143266_0_0_2"/>
    <dbReference type="OrthoDB" id="91988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="157" mass="16093" checksum="52997BA2B6F82AEE" modified="2013-07-24" version="1">MTTLDSVATVVHVLFGGLWIGSVAFVALAVLPLGRDASIDPEPLSAVVDRLVTLSRLAALVMLATGGHVLYHVTLGGEVTAEPLTSSGRGHLVLTMVVLWVGVIATVEIGNSKLSDGLDAGKLREPTRTALPWFQAAALLGVAVLTIGGMLSAGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUV7</accession>
    <name>R4VUV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444945.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00480"/>
    <dbReference type="EnsemblBacteria" id="AGN00051">
        <property type="protein sequence ID" value="AGN00051"/>
        <property type="gene ID" value="L593_00480"/>
    </dbReference>
    <dbReference type="GeneID" id="16181583"/>
    <dbReference type="KEGG" id="sali:L593_00480"/>
    <dbReference type="eggNOG" id="arCOG02999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158587_0_0_2"/>
    <dbReference type="OrthoDB" id="122429at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="101" mass="10936" checksum="438F00655EAD152F" modified="2013-07-24" version="1">MSPSVVALDELDAEPHAVLFDDEPKTIRLRLESGEEIAAHSHPDRQIVFHLLSGSIVVTLDGEEHTLEPGDVARFDGERAVSPRAREDSTALIVLAQKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUY7</accession>
    <name>R4VUY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445944.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05505"/>
    <dbReference type="EnsemblBacteria" id="AGN01050">
        <property type="protein sequence ID" value="AGN01050"/>
        <property type="gene ID" value="L593_05505"/>
    </dbReference>
    <dbReference type="GeneID" id="16181372"/>
    <dbReference type="KEGG" id="sali:L593_05505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1125"/>
    <dbReference type="eggNOG" id="arCOG04450">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030328_0_0_2"/>
    <dbReference type="OrthoDB" id="33626at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="605" mass="61794" checksum="623BD6C625400FC5" modified="2013-07-24" version="1">MSARKLLRIARWEVATSTGTIDRKTVAVLLVALLAAAAGAPAITSGAGQLDAGLYTVAVDDEHPYSDAIESRDSLRIVDSENRADLVVTDGDVRVADGTSGDAALSELRDAIRSYNNRNLREEDDQAAAFPVFVDLEFVEEAGTTIGEDGTSDGDTTGDGTSDGTGDTTGDGSGTDGGGSGETDGSADDSDGTTDDGSIGGSTGSSDGRLPVPDVGVGGSGAQSGTPGDISAPFPFASLVLAFLFVLPMNFVIQAYGSTIMDERRNRRGELLLVAPVTRTDVVGGKTLPYVGGIAAVTVTIAALVGGGPLSVLAVMPIGLLFLGLTFVAAMFARSYKELTFLTVSISVFVTSFVFVPAIFTDVTPIALISPLTLVVIDLKGSAVDAGGVLFATGPSLLASGVLFGLGIGIYREEDMFTQVPVHGKALDALAAWIHRPRHVAAMTALFIPFVFVLELLAVAVLFALPLAVSLPAILVLVAVVEEVAKSLHVFAAFEHDRFDRALPTALGLGLASGAGFFLAEKATHAIQLVGLDQLEVGQAAFAPSTGVGPALAVALFLAPLVLHGVTAAISAVGASENAKTYGSALAVAILVHAGYNLGVILLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUY8</accession>
    <name>R4VUY8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444980.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00655"/>
    <dbReference type="EnsemblBacteria" id="AGN00086">
        <property type="protein sequence ID" value="AGN00086"/>
        <property type="gene ID" value="L593_00655"/>
    </dbReference>
    <dbReference type="GeneID" id="16181430"/>
    <dbReference type="KEGG" id="sali:L593_00655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.133"/>
    <dbReference type="eggNOG" id="arCOG10292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100195_0_0_2"/>
    <dbReference type="OrthoDB" id="73609at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="24265" checksum="D2811E50AEBD386A" modified="2013-07-24" version="1">MTHSVLLIGGNRFPFHRLADRKTAITAAFDDRIDVTTTTDKDDLTDLAGYDAVVDYLTDSTLSDEQRDGLLSFVEDGGGYVGIHCAADLTSTVADDPDELIDSREEPFPDLREMLGGHFVTHPEQSVVDVRIVDHHSPITATLEDVSVWDEPYVLDVDDDVRVLARMDHPEHADMPVAWTKPYGDGRVFYCSLGHGTASLTHDGVQALLRNGTRWAVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ6</accession>
    <name>R4VUZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445959.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05580"/>
    <dbReference type="EnsemblBacteria" id="AGN01065">
        <property type="protein sequence ID" value="AGN01065"/>
        <property type="gene ID" value="L593_05580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181440"/>
    <dbReference type="KEGG" id="sali:L593_05580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1141"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_1_0_2"/>
    <dbReference type="OrthoDB" id="67420at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="30330" checksum="462A2EA0E843E858" modified="2013-07-24" version="1">MNVSDAMTPRSALVTVELPGSRDDALEHLREGAFSSVPVVKVEDGHERYRGLVSRETLIEQPDEDQLALLMEEVPTITANADLRAAAALMVSEQARRIPVVDGELEGIVTITDVVDAIAKGNVPGDANAGDIATRSVITAYQGTPLAVAERQLFHADMPYAVVLDDEGGMAGVFTEQDVIEVAEVVEGETKTGNSFADQDDDWMWEGIKGVGSRSVTTRDVELPEGTVADFMTGDVVTISQSKTAQDAAQAMITHDVEQIPLVSGGDLAGIVRDVDLLAAIAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV44</accession>
    <name>R4VV44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445035.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00141">
        <property type="protein sequence ID" value="AGN00141"/>
        <property type="gene ID" value="L593_00930"/>
    </dbReference>
    <dbReference type="GeneID" id="16180199"/>
    <dbReference type="KEGG" id="sali:L593_00930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.191"/>
    <dbReference type="eggNOG" id="arCOG14367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070503_0_0_2"/>
    <dbReference type="OrthoDB" id="62167at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="36325" checksum="AF65586889BBF9B5" modified="2013-07-24" version="1">MPEFRVAVDPETADAFQTEVDLLGFGDADEYLSWVVDNRASIEQGTESAELLDSYHERLVALEERLAAEGVDPATVDADTDPVSDARPDTIGTSDRTSTTDATTAKGSSSGRSTQSTLSDSQADGVDTIATSSDLSPSVDTGGTAANPDGREGVNAGGASSSEGDEQRAASDGGVSAEAEITSMHLQPERVQRVREDPVTRDADSLKDVETNRLDELSRRAVAETRQQLDREVETGLDYDSATTLGDSDVRPGEDLADLDALDVPGRTQGLVEARRVAVGRALAYLHDVGQARKRDFVDELYGDWPAGYESAAGWWRCIRGALEQVDAVDGGHIWEYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV71</accession>
    <name>R4VV71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01065"/>
    <dbReference type="EnsemblBacteria" id="AGN00166">
        <property type="protein sequence ID" value="AGN00166"/>
        <property type="gene ID" value="L593_01065"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01065"/>
    <dbReference type="eggNOG" id="arCOG01020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="22"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="416" mass="45022" checksum="D5DA20C8445F4828" modified="2013-07-24" version="1">MTSTLAGCIPGSGDGGDNLEGPIRIGHLAPLQNPLGIGSRRTATMAVDQISDDGGIMDEEVEVVHADTGGNPGTAQTEAERLVAEEDVDVIVGTFVSEVTQAIMDYVAQEGVPLIVTGSSAPSTVTDFIGQDYDRYKNFFRTGPINSTFQAEAMVDYVNHLNDLHGWSSFAVVADDAAWVEPHLNVLPDALEEQGYDLVMEQSLNINIDDFSPVINDVVESDADAMIRFFAHINAAPLLVERAQRELTFGIEGIHVTGMHPAFAQLTEGAATYETTSQSGGGGTTDITENTIPFVESYRERFADSDPPVGHPMYMGFNTYDAINVYKAAVERGGTWDYGNDLDSIVDAMLATDHTGVAGQIQLYGPDAEYPHDAKETRDDEGTISNFPITQWQPQGALECVYPEQHATAEHMAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVF1</accession>
    <name>R4VVF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01315"/>
    <dbReference type="EnsemblBacteria" id="AGN00216">
        <property type="protein sequence ID" value="AGN00216"/>
        <property type="gene ID" value="L593_01315"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.268"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="426" mass="44293" checksum="4A41A0E695879148" modified="2013-07-24" version="1">MDVDDDRLQFWALYLTRFAQGFGFISLITLLGPYITELDPQATTILGVTISAGLIIGMFTTGFTLAQTVAVVPLAWAGDRYDKRTVLLIVLALGTAIYALFPMVDSSASFIAIRGLQGIAVTGAGLMSLSLVGQIADVGSRANAIGKANAASFAASILGSGSAGVIYDAFGFAPVFYIIVAMMAGAWLGVYTFLEPDETRIEGFPFTDLAVNRKIATIAGFRAQYAVAVTLVRTWVPIYAGVSVAEGGLAVSGLAISLTVIAEKFTNMLCQPVTGRLSDRAGRSAFVFAGGGAYGLIAIAIPSATWIGTAIGTEVTLPLLGSLPAAYFPLVFFSGLLGIADAFREPASMALFADEGAGEGVASSFGIRELIWRPGSVGAPLLGGWLMTAVGMDWVFFVGGAFALTGAGAFLAILVWDHGAGALQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVH9</accession>
    <name>R4VVH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06255"/>
    <dbReference type="REBASE" id="65271">
        <property type="entry name" value="M.SspHBORF6255P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01200">
        <property type="protein sequence ID" value="AGN01200"/>
        <property type="gene ID" value="L593_06255"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1278"/>
    <dbReference type="eggNOG" id="arCOG00889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468243_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="582" mass="66958" checksum="443B61EEB461198E" modified="2013-07-24" version="1">MYAIEYYCPHCDEEGRDRAVYKGYKQAEEVDIEKYEAAVREWEDADDLREFVPSQDVPLGILTDSTAFEGSIGGGHNLLGHGYEQWTDIFDERQLLCLSKLLEAIDDVENQNAKEYLLLALSDSLMFNNTFTIYNLQGHKVEGIFKTNSFKPQKEFVENNVWGTEFGRGTFVKSWKKVLAGVEWAAAPVERYIEDGSTQKTPPFNKAVGDDHEVHCGDARQLEYEDEFDAVLTDPPYYNNVIYSELSNFFYVWLRIVLQDEYEPFETETTPRAESIVANPAEGKDETDFEEELHQSFSKIHQALKQDGVLAFTYHHSDAESWGELLEALCEVGFEVTATYPVTADTNRATYKLTEGESVDFDIIIVARPAQDREPISWNSLRRNIYRTAQKTRTRLEENRNLSRGDIGVVEMGRCFHEYSKHHGEVKRAGEPMSAKDVVDEIYGVIQHGADVGEIDVFVDLLETPNATYDDLNKLTRGTDATPERMEDMRLYRMEDGFTLGTWDDEKRIAYIQSRVDSGDELTDLDRAQFLRWRWEQGKSVTEYLEQWEITDDLRELCEGLADATGDETYRNILESRLGDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVN0</accession>
    <name>R4VVN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446149.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01255">
        <property type="protein sequence ID" value="AGN01255"/>
        <property type="gene ID" value="L593_06540"/>
    </dbReference>
    <dbReference type="GeneID" id="16181794"/>
    <dbReference type="KEGG" id="sali:L593_06540"/>
    <dbReference type="eggNOG" id="arCOG04907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465172_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040493">
        <property type="entry name" value="DUF5518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17647">
        <property type="entry name" value="DUF5518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="184" mass="18233" checksum="9BB79DA7D186D456" modified="2013-07-24" version="1">MLSNAELVDVTQALATWTAVGLIAIGAILFVLGFAYVAVRRRTHSRAAAGEQVSNFGANALLGAILAIVLSFVPFSQALGGIVAGYLESGSSERVVGVGAFSGFLSVAPLLALLVFVLAGIVAGLLEVGEGALALVVGAALLLSLALLATVGAGLGAIGGFLGGKLADRERNGGSSANESDQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWF5</accession>
    <name>R4VWF5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nth</name>
        <name evidence="8" type="ORF">L593_03325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445510.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03325"/>
    <dbReference type="EnsemblBacteria" id="AGN00616">
        <property type="protein sequence ID" value="AGN00616"/>
        <property type="gene ID" value="L593_03325"/>
    </dbReference>
    <dbReference type="GeneID" id="16181919"/>
    <dbReference type="KEGG" id="sali:L593_03325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.673"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_2"/>
    <dbReference type="OrthoDB" id="124734at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="227" mass="25443" checksum="E9BB5BFFA2ECF4C9" modified="2013-07-24" version="1">MGEPLELREAQAREVVDRLAEEYPDSTISLHFSNRLELLIAVILSAQCTDERVNAETEHLFEKYDSAEDYAEVSQEELAEDLNSINFYNNKTSYIREACQIIVEEHDGEVPDTMEELTELPGVGRKTANVVLQHGHDVVEGIVVDTHVQRLSQRLGLTEESRPPAIEEDLMPVVPEDRWVQFTHLLIDHGRAVCSAQSVDCEACVLADICPSEQGDSEVDLASGEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWJ0</accession>
    <name>R4VWJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446504.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01610">
        <property type="protein sequence ID" value="AGN01610"/>
        <property type="gene ID" value="L593_08325"/>
    </dbReference>
    <dbReference type="GeneID" id="16182366"/>
    <dbReference type="KEGG" id="sali:L593_08325"/>
    <dbReference type="eggNOG" id="arCOG08095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444730_0_0_2"/>
    <dbReference type="OrthoDB" id="80601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="21731" checksum="0C93CD4BD428AB2F" modified="2013-07-24" version="1">MSLDVDGPELRERVRSAFVDAEPLTTAEVAVAADVPEPAVTDALEELVEAGDLRVTEVRGVDIRQRKYAEDDDEIDLEEPFDLYFRPAEDLLETVGTRDGSDVPEDADPVERRLARMDVGGASGMMRDWKRDAVRAAREHLIETGPCDPAELREVVYPAHEAGFDDADAWWDCVRPRLARLPGVVIDRGTWDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWQ3</accession>
    <name>R4VWQ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ORF">L593_08625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446564.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08625"/>
    <dbReference type="EnsemblBacteria" id="AGN01670">
        <property type="protein sequence ID" value="AGN01670"/>
        <property type="gene ID" value="L593_08625"/>
    </dbReference>
    <dbReference type="GeneID" id="16179928"/>
    <dbReference type="KEGG" id="sali:L593_08625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1767"/>
    <dbReference type="eggNOG" id="arCOG01122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_2"/>
    <dbReference type="OrthoDB" id="98657at2157"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="23839" checksum="12B1D4BAD661D174" modified="2013-07-24" version="1">MDAATLKRRAGERAVEAVDDGDVVGLGSGSTAAAAIRALGERVDSGLDIQGVPTSHQSREIALNVGIPVVDLDQVEAVEVAIDGADQVATDADSASAIGAPPLIKGGGGCHAREKIVDAAAEELLIVVDPSKLVPTLDAAVPVEVLPAARTTVAEELRDIGGEPTLRDATEKSGPVVTDNGNLVLDTDFGEIDDPPSLATACSGIPGVLDHGIFVDLADRVLVGREDGVEALEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWY8</accession>
    <name>R4VWY8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="8">GGGP synthase</shortName>
            <shortName evidence="8">GGGPS</shortName>
            <ecNumber evidence="8">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_04125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GGGP/HepGP synthase family. Group I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445670.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04125"/>
    <dbReference type="EnsemblBacteria" id="AGN00776">
        <property type="protein sequence ID" value="AGN00776"/>
        <property type="gene ID" value="L593_04125"/>
    </dbReference>
    <dbReference type="GeneID" id="16180843"/>
    <dbReference type="KEGG" id="sali:L593_04125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.838"/>
    <dbReference type="eggNOG" id="arCOG01085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095211_0_0_2"/>
    <dbReference type="OrthoDB" id="74340at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002094">
        <property type="term" value="F:polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039074">
        <property type="entry name" value="GGGP/HepGP_synthase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026417">
        <property type="entry name" value="GGGPS_Halobacteria"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40029">
        <property type="entry name" value="PTHR40029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04147">
        <property type="entry name" value="GGGPS_Halobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="8">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25304" checksum="DA9663A8CE804E16" modified="2013-07-24" version="1">MTAPWTEWDHILKIDPDKELVDGETFADVCQTGTDALEIGGTLDITSEKMSRVIEACAEYDVPLYQEPSNPAVVVDDEAVDGFLVPVVFNAGDMAWMTGFHKEWVKTDHVDWARTTTEGYIILNPDSSVGQLTEADCDLDAEDVAAYAEIAEEMFGQEIVYLEYSGMLGDPEKVRAAADVLEETTLFYGGGIHDYDSAHTMASEADVVIVGDLVHEEGVDAVQETVQGAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWZ0</accession>
    <name>R4VWZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01725">
        <property type="protein sequence ID" value="AGN01725"/>
        <property type="gene ID" value="L593_08900"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1824"/>
    <dbReference type="eggNOG" id="arCOG06229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122660_0_0_2"/>
    <dbReference type="OrthoDB" id="6449at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="26621" checksum="2123928173DCED99" modified="2013-07-24" version="1">MAEEGDLVDDAYGSRAEAELPFDITIRSDTTSEELTDILAEERDFLHYIGHIDDDGFRCTDGRLDASQIEDVGVDAFFLNACQSYEQGTALVEAGAIGGIVTVRNVANLGAVKIGRAVAQLLNSGFPLRPALDIARDESIIGCHYIVVGDGGLSIVQPMSGTPYLGDIEQTGEKYKLSLDLFGASPGMGGVFSPHLAGVSEYYLASGSITELVVTGDELDSFLHNENFPVRRNSWLEWSNELSAEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX67</accession>
    <name>R4VX67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445750.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04525"/>
    <dbReference type="EnsemblBacteria" id="AGN00856">
        <property type="protein sequence ID" value="AGN00856"/>
        <property type="gene ID" value="L593_04525"/>
    </dbReference>
    <dbReference type="GeneID" id="16181207"/>
    <dbReference type="KEGG" id="sali:L593_04525"/>
    <dbReference type="eggNOG" id="arCOG03065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_3_1_2"/>
    <dbReference type="OrthoDB" id="115195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14765" checksum="25EAD074B4CF8100" modified="2013-07-24" version="1">MSDAYRSIDDPGGIETGAPRGQRDDEPPAPSTEAVLDLLGDDYAREAIEAIRTEPRSGAEVAAATGMSKPTAFRRLNALVEVGFASVRRRIDPDGGHHSKVYYFVADSLSVEFDDATRVTVERADSPDAGVRARSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXC0</accession>
    <name>R4VXC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446779.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09700"/>
    <dbReference type="EnsemblBacteria" id="AGN01885">
        <property type="protein sequence ID" value="AGN01885"/>
        <property type="gene ID" value="L593_09700"/>
    </dbReference>
    <dbReference type="GeneID" id="16182789"/>
    <dbReference type="KEGG" id="sali:L593_09700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1997"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026973_0_0_2"/>
    <dbReference type="OrthoDB" id="95312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="4">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="48660" checksum="F3EC515C5C785925" modified="2013-07-24" version="1">MTAQSIPAAARTLPTEALADDDPGYDEEIPRGLRRTNRWRGVAGLTLLAIGLGLLLEQPAALLAGVFGVAFAAYGQIGAAPTPELDVERTIDVDEPAVGDEVPVTVTVTNEGEDTLTDLRLVDGVPDGLAVADGAPRGATALRPGSAVELTYEVVATRGAHAFDSLVAITRDVTGATERVVEVDAPDRIICTPELPADPPSFPLRAQTTRYTGRTTAEEGGDGVEFHATREYRPGDPLSRIDWRRTARTRDLTTVEYRRERAASVMLVVDARKAAYASHEPHAETSVDRCVDAARTVAASLLADGHSVGLTAVSPRACWITPGHGLEHRLAITTTLAEHESFARRPPEESTNVYGAGREIRGRIASDTQVVVFSPLIDDGGAQLAHRFDAHGHLTTVVSPDPCVTDTVGQQTATISRALRITQARHGGLPTIDWQREERLERALLRSNRRWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXQ2</accession>
    <name>R4VXQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446934.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10475"/>
    <dbReference type="EnsemblBacteria" id="AGN02040">
        <property type="protein sequence ID" value="AGN02040"/>
        <property type="gene ID" value="L593_10475"/>
    </dbReference>
    <dbReference type="GeneID" id="16182299"/>
    <dbReference type="KEGG" id="sali:L593_10475"/>
    <dbReference type="eggNOG" id="arCOG04674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123164_0_0_2"/>
    <dbReference type="OrthoDB" id="120194at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043809">
        <property type="entry name" value="DUF5791"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19104">
        <property type="entry name" value="DUF5791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="15386" checksum="FDBCB6537A7FD74F" modified="2013-07-24" version="1">MLHEERTSVDAETPAGLAEEYCTELGAIVEAHGVDDVAADTGIDEATLRALVDGDAERAAAALDLEDAAAIQALDSALDADAIYAEACDHLLLGMSMAVLDVDTIAAEYEGERSGKGIQQRIERRAPMTLAEYARIEHFVANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU9</accession>
    <name>R4VXU9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">nac</name>
        <name evidence="7" type="ORF">L593_10775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446994.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10775"/>
    <dbReference type="EnsemblBacteria" id="AGN02100">
        <property type="protein sequence ID" value="AGN02100"/>
        <property type="gene ID" value="L593_10775"/>
    </dbReference>
    <dbReference type="GeneID" id="16180561"/>
    <dbReference type="KEGG" id="sali:L593_10775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2221"/>
    <dbReference type="eggNOG" id="arCOG04061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146475_1_0_2"/>
    <dbReference type="OrthoDB" id="105165at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="13837" checksum="0303DE6B463F1E27" modified="2013-07-24" version="1">MFGGGGGFDPRKMEQMMEQMGIDMDELDAEEVVIKTADSEFVFDAPDVTKMDARGQATYTVVGDPEERPRGAGGDASAVESADEDAAADEGGIPEEDVEMVQMRTGASEAEAREALEDNDGDLAAAVAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXY9</accession>
    <name>R4VXY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447029.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02135">
        <property type="protein sequence ID" value="AGN02135"/>
        <property type="gene ID" value="L593_10950"/>
    </dbReference>
    <dbReference type="GeneID" id="16181379"/>
    <dbReference type="KEGG" id="sali:L593_10950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2258"/>
    <dbReference type="eggNOG" id="arCOG01744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093715_0_0_2"/>
    <dbReference type="OrthoDB" id="100564at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22030" checksum="FF4198EB71D8A731" modified="2013-07-24" version="1">MVDVTGHFGMALLFAAPAWAIWGRRGALGFTAFAVVTAMLPDVDLVLRTHFPVTHHGVTHTVAFVALVSVLVGAFAARWLTDSFNAHRLIRSTTISEDIVFAFGTAGLFVGGASHIFADVPSAPDIAAPLSPFWPVYTKPVIVDVVYYDNPFWNVGLLAVAVSVHLVLAWHERYPLETRYRIGEPIGDVDGSEIVGMVDQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY80</accession>
    <name>R4VY80_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447094.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11275"/>
    <dbReference type="EnsemblBacteria" id="AGN02200">
        <property type="protein sequence ID" value="AGN02200"/>
        <property type="gene ID" value="L593_11275"/>
    </dbReference>
    <dbReference type="GeneID" id="16181612"/>
    <dbReference type="KEGG" id="sali:L593_11275"/>
    <dbReference type="eggNOG" id="arCOG02884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047794_1_0_2"/>
    <dbReference type="OrthoDB" id="64460at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="340" mass="36324" checksum="4A6A664425043058" modified="2013-07-24" version="1">MTYSESRMPGWQRALSDRVAVDIVIAWAVAATTFLAVVIDAPQAIRVLFGGSALVVLPGYVLVAMLFPHRGSVAAPGRLSSIGAPDRVNWRVRLALSFGLSLALLPLLGIVVSVSPWGFSDQTVAAAFLAFVVIGGLLAAIVRRRLPPEDRFRIPLDRWVGEVQAALWSGPPTKRALNALVLLSIGVALVAAGGVIAMPQGGQSFTDFAVLSENDDDELVAGGYPEELDADDPAPLVTAVENHEGDPTEYTVVVTMERRPAAGSDAGGDATASGETVELHRYSATVAPGQRWTQRHELRPALDGDRLRVHYYLYRGDAPTEPDASTAYRHLWVTLGDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYS9</accession>
    <name>R4VYS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446290.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07245"/>
    <dbReference type="EnsemblBacteria" id="AGN01396">
        <property type="protein sequence ID" value="AGN01396"/>
        <property type="gene ID" value="L593_07245"/>
    </dbReference>
    <dbReference type="GeneID" id="16182077"/>
    <dbReference type="KEGG" id="sali:L593_07245"/>
    <dbReference type="eggNOG" id="arCOG04724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253564_0_0_2"/>
    <dbReference type="OrthoDB" id="89371at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="23698" checksum="376BBB0861D80F53" modified="2013-07-24" version="1">MSEAGDHSDAETGTDAPTDEDPLADVPDWDDEYVDEVAGRLVHNYDLEQDRTVEGESFDLYGAMEIHSQKHIIHPSISFAHHESHEHLFLRRVEHATVAEIDRLVALGHDLADEWVEADEEHYSTDFTFVLVAPEVPDDVDERVAAVDERTLLKYGYNGHYDVHVAVVAPEQERLVVSEDADVAEALALWEPIEREEPGLLGLISRRLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYZ0</accession>
    <name>R4VYZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446355.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07580"/>
    <dbReference type="EnsemblBacteria" id="AGN01461">
        <property type="protein sequence ID" value="AGN01461"/>
        <property type="gene ID" value="L593_07580"/>
    </dbReference>
    <dbReference type="GeneID" id="16182155"/>
    <dbReference type="KEGG" id="sali:L593_07580"/>
    <dbReference type="eggNOG" id="arCOG09177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878853_0_0_2"/>
    <dbReference type="OrthoDB" id="75646at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="37"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="35510" checksum="517D8C49DA5E8DB5" modified="2013-07-24" version="1">MAGVVTLSIEIELGWGVHDIDEFAHLSDRGRSERRYLTRLLDLTETLDLPISFDVVGHLCRVTCDGVHDGPHEPGWFESDPGTDVATNPLFYAPDAIDDVAASAVDHELCTHTYSHVPCHSVARETLAWELEQAQSQLQEFAGSRTVSIVPPRHYRPPADALREAGIETMRICRDTSDRSRPARAKELVLGPHPVFEPRVVDGVVETYCTSYPSLTSAALPAGQRRAARPFSAMPVRTRQYLQRRYLRRAVDDAAANDHYTHLWCHLYDLSNPYQWEPIAAFLRHLASLREQGEIEVLTMAALNEHVRDRGVAMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ22</accession>
    <name>R4VZ22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447409.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12880"/>
    <dbReference type="EnsemblBacteria" id="AGN02515">
        <property type="protein sequence ID" value="AGN02515"/>
        <property type="gene ID" value="L593_12880"/>
    </dbReference>
    <dbReference type="GeneID" id="16182734"/>
    <dbReference type="KEGG" id="sali:L593_12880"/>
    <dbReference type="eggNOG" id="arCOG05411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846271_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="37164" checksum="7E75946D3566F682" modified="2013-07-24" version="1">MVTRLENTEYAHVSGFNYQPSHASHGMEIWGTDFQPSLMRKELWIGKQHFPGMNTVRLWLSHDAYLRFPERMPERVGEVLDMGADYDVEFIVTLFNGWHSYPDFGGLHPQSLREWHDGTLFDEAFAPYVDAIVGEFADHDSVLAWDLCNEPLLSVQHQGVLEDLTVDRSLVIYQFLERVYERIRTHDPVAPTTVGSIGTRTHVEIFEPLAEVLSTHAYLAWNRAETPAELHEKLDEIVALANDVEKPLLATETGWGALDDQKRVEILDVVLAALDERDVGFTAHLLHHTPVADGHREAYGPIYDAGNLSFVDSDGSLRAGHDVFNEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZQ7</accession>
    <name>R4VZQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446595.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08780"/>
    <dbReference type="EnsemblBacteria" id="AGN01701">
        <property type="protein sequence ID" value="AGN01701"/>
        <property type="gene ID" value="L593_08780"/>
    </dbReference>
    <dbReference type="GeneID" id="16182451"/>
    <dbReference type="KEGG" id="sali:L593_08780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1799"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565678_0_0_2"/>
    <dbReference type="OrthoDB" id="122403at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8989" checksum="F393834D87EFF4FD" modified="2013-07-24" version="1">MRVEYDRDVCIGMFQCVAEWDAFEKDEDAGKAVLAESEEADEDVFVREVPDGAELDAKFAARACPVDAIAIYDDDGEQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZR5</accession>
    <name>R4VZR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">L593_14030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447639.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14030"/>
    <dbReference type="EnsemblBacteria" id="AGN02745">
        <property type="protein sequence ID" value="AGN02745"/>
        <property type="gene ID" value="L593_14030"/>
    </dbReference>
    <dbReference type="GeneID" id="16181082"/>
    <dbReference type="KEGG" id="sali:L593_14030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2871"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OrthoDB" id="104144at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="273" mass="28528" checksum="D0CB994FB7292E6B" modified="2013-07-24" version="1">MQVGIVGQRGRDRAVEVTASVRDELEARGVEVVLDEATASALDVAGVPPEAFERCDLAISIGGDGTFLYAARAGGTTPIMGVNLGEVGFLNAVPPDRAVEAASEAVSNLEDGTLSIRDVPRLRAECGNWSSEPAINEVLVQGPRRGAGADATVSISVDDSTYTREIADGVLVATPTGSTAYNLSEGGPLVHPAVDSMVVTPMFPRTGARPLVVDDGSTIELRVEDATSGYVVTDGRQAREFEAPFTATVEVSEEPLRIAGPDVNFFEALGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZV4</accession>
    <name>R4VZV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing amine-oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447679.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14230"/>
    <dbReference type="EnsemblBacteria" id="AGN02785">
        <property type="protein sequence ID" value="AGN02785"/>
        <property type="gene ID" value="L593_14230"/>
    </dbReference>
    <dbReference type="GeneID" id="16181153"/>
    <dbReference type="KEGG" id="sali:L593_14230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2913"/>
    <dbReference type="eggNOG" id="arCOG01523">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039679_0_0_2"/>
    <dbReference type="OrthoDB" id="47925at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="423" mass="45308" checksum="38DE5AF212655A9E" modified="2013-07-24" version="1">MTDERVVIAGAGPAGLVAARHLADAGVDVTVFEADETVGGRVASRAVEGYTLDRGFQVLFTGYPTVQRELDLDVLELRTFKPGAVICRPNGRSVVGDPLRDPGSISQTLLNREITTRDGYRLWKLRRELRGESRGAIFSGADRTIREELERRGFSEGFVEAFAAPFLGGITLDRSLETSKRVFEYVMKVLAAGKTVVPAAGMGAMTEQLAANARDAGARIETGSAVEAVTADGTGGDFDLGNETVDGHAAIVATDAPTARDLTGVDAIPTDGHAVATQYYTVPEHSAPPGKRLHLNAESEQPNTLVTLSNVAPEYAGENDRALISATFLGDPDATNAKLDDKTRRTLQSWYPERQFGDLQLLETDRIDFAQFAQPPGCHDDLPGVAAPEGRCYLAGEYTQWSSIDGALQSGRDAAQRVLADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4W026</accession>
    <name>R4W026_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">L593_09430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446725.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09430"/>
    <dbReference type="EnsemblBacteria" id="AGN01831">
        <property type="protein sequence ID" value="AGN01831"/>
        <property type="gene ID" value="L593_09430"/>
    </dbReference>
    <dbReference type="GeneID" id="16182706"/>
    <dbReference type="KEGG" id="sali:L593_09430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1941"/>
    <dbReference type="eggNOG" id="arCOG00660">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_2"/>
    <dbReference type="OrthoDB" id="42664at2157"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="71"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="35706" checksum="CBA7ECC482D6C04F" modified="2013-07-24" version="1">MSRSRKPEWLRSRIPTGEEFTRVKATLREHDLTTVCEEANCPNLGECWSGAEGGGPAAASGNAAAPGVEGNRGGTATFMLLGDQCTRNCGFCDVDTGGGQPLDPDEPENVASAVAEIGLEYVVLTSVDRDDLEGQGAAHFAETIRELKRRDPGVLVEVLIPDFQGDPDLVGEIVDAGPDVIAHNVETVERLQERVRDPRAGYEQSLSVLEQVASESGAHAKTSIMLGHGEHDHEVYQALSDCREAGVDVITLGQYLRPSRDHLPVREYVHPHVFDTWRDVAEQELGFLYCASGPMVRSSYRAGELFVEALQREDATLAEARRAARNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W034</accession>
    <name>R4W034_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="3" type="ORF">L593_14670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14670"/>
    <dbReference type="EnsemblBacteria" id="AGN02870">
        <property type="protein sequence ID" value="AGN02870"/>
        <property type="gene ID" value="L593_14670"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2995"/>
    <dbReference type="eggNOG" id="arCOG02726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10688" checksum="5995E6AD941885E9" modified="2013-07-24" version="1">MDSAMSEQRVDEDEVEHVASLARVDLDEGDAERFVEQFADILEAFDALDEVPAVDRDADLTNVMRPDEERDSLDQEEALANAPESEDGFFKGPNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W072</accession>
    <name>R4W072_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446775.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09680"/>
    <dbReference type="EnsemblBacteria" id="AGN01881">
        <property type="protein sequence ID" value="AGN01881"/>
        <property type="gene ID" value="L593_09680"/>
    </dbReference>
    <dbReference type="GeneID" id="16182813"/>
    <dbReference type="KEGG" id="sali:L593_09680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1993"/>
    <dbReference type="eggNOG" id="arCOG02984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_2_2"/>
    <dbReference type="OrthoDB" id="122478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="7131" checksum="F40A1BBD8E1A794C" modified="2013-07-24" version="1">MPTGTVDFFNDSGGYGFIETEDSDEDVFFHMEDVGGPDLEEGQEVEFEIVQADKGPRAKDLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W086</accession>
    <name>R4W086_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447819.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14955"/>
    <dbReference type="EnsemblBacteria" id="AGN02925">
        <property type="protein sequence ID" value="AGN02925"/>
        <property type="gene ID" value="L593_14955"/>
    </dbReference>
    <dbReference type="GeneID" id="16181585"/>
    <dbReference type="KEGG" id="sali:L593_14955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3054"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="41818" checksum="077EBBA82163B465" modified="2013-07-24" version="1">MDFALSEEQKAIRDEVRKFAENEIEPVATELDEAEKYPHDVMDEAAKMGLTGAHIPVEYGGAGYTPFEMALITEELFAVDPGTGLSITSAAFGADSIMANGTEDQKERYLEPIAAGDAVMGAAISEPDVGSDVSSVSTTAEKDGDEWVINGNKMWITNGSVGDYFVVMCKTDETDDRYSGFSQIVVESDRDGFTAEKITGKLGIRASDTAELIFDDVRVPEENLIGTEGAGFLQLMQFFDETRTMVAAQGVGIAKGACERALEYAQEREQFDRPISEFQAIQHKLSEMHTRTEAARQLTYKSAWSVENEGQQLTALASMAKEFASATAVEVADEAVQIHGGAGYVNDFDVERLYRDAKITQIYEGTTEIQKNIIARELLGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W099</accession>
    <name>R4W099_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_15030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447834.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15030"/>
    <dbReference type="EnsemblBacteria" id="AGN02940">
        <property type="protein sequence ID" value="AGN02940"/>
        <property type="gene ID" value="L593_15030"/>
    </dbReference>
    <dbReference type="GeneID" id="16181122"/>
    <dbReference type="KEGG" id="sali:L593_15030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3070"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_2"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="42513" checksum="4924B411CA10F923" modified="2013-07-24" version="1">MAVDDPTPTDLQCSACGATYEAGPDEPWRCSCGSPLDFAENPVPQGSPPPFSRLDTRRGLWAFFEFLPVTQQVTLGEGFTPLVGAPEWNAQFKLEYVFPTGSFKDRGATTTLSRAAELGVDTIVEDSSGNAGASIATYAARANVDAEIYVPGELPQSKLMAIQRAGARPVRIDGSREDVSEACIEAVEDGDAWYASHAWNPAFLAGTMTFALEVAAQRDWSIPDAVVLPTGNGTLSLGAYRGFKALEDAGMIDDVPRIMVAQASGYAPIVDALDGVEPDPITEEPDDVPDVPTTSGGLGVSIGDDGDDDRLPDNELADGIQIRDPPRKDQIVAAVQETDGAAIEIGENQLEIALDRLHRSGFYVEPTCAVGPAALRAFRDEGILADDADVVVALTGSGLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0F4</accession>
    <name>R4W0F4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446880.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10205"/>
    <dbReference type="EnsemblBacteria" id="AGN01986">
        <property type="protein sequence ID" value="AGN01986"/>
        <property type="gene ID" value="L593_10205"/>
    </dbReference>
    <dbReference type="GeneID" id="16181980"/>
    <dbReference type="KEGG" id="sali:L593_10205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2103"/>
    <dbReference type="eggNOG" id="arCOG06225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_2"/>
    <dbReference type="OrthoDB" id="2226at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="897" mass="102083" checksum="FA5EE47922B2F0B9" modified="2013-07-24" version="1">MPLHNRTVRQDVRELGALLGDVLEDQTSTADFETVEDLRTSAIDYRGGELGSRQHLHDVLDGLSPEESSVVARAFTTYFELINLAEERERVRAIRQGSQDDDLEDSLEEAAEELADADLDPDEVEAVLDDVLIEPTFTAHPTEARRKTVKSKLRAVANHLETLDERHLTDKEQGHVERDVDAEVTSLWQTPQVRNRRPEPEDEARNVQWYLENTLYDVVAEVYDEFEAALDDEFDDVDVPKLFEFRSWAGSDRDGNPFVTPEVTTNTLERQRRVVLENYRQDLKALSGVLSQDGSRIDVGEAFEASLEEDRERLPKIAEEAEERYPGEPYRQKLKLMRERLQRVGDVRPGGYEDATELHEDLQDVAKSLRRNGADAVDEAHVEPLARRVDTFGFSLASLDLRDHQANHTETISELLGREGLDYAGMDEEERVEVLTDGILQDEPVVDLEDREGLSDTAARVARRFHKLGDWQREFGVEAIDTYAISMTDEPSHVLEVLFLADHADVVELPGHCGLDIVPLLETEYALSGARRIMGTLFENEAYAQALEARDGLQEIMLGYSDSNKENGFLAANWSLYKNQRRLAEICDDFDVTMRLFHGRGGSISRGGGPMNDALLSLPNSTITGQVKFTEQGEAISEKYGNPRIAERNIEQMLNAQVRARHRAIEQPVEDVPEAWYDAMDEMADAAREEYRDLLETDGFVQYFEEATPITVIEDLNMGSRPASRSGERNVEDLRAIPWVFSWTQSRCILPGWYAIATGIESWLEDGGDVETLQEMYEEWPFFQTRLDNAAQALGRTDFEIAQEYADLAHPDLREEFFPRLQDEYEQAVDLLTDITGRDHPIDREWLRESLDRRNPYVDPLNLLQTHLLAQTHRTETEERTLRLTVKGIAAGMKNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0G6</accession>
    <name>R4W0G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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        <property type="entry name" value="Enolase-like_C_sf"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="349" mass="38648" checksum="1F525D5F074E79D6" modified="2013-07-24" version="1">MNGYEALADLPLAITNCELRRLEGETTSDFTRVSTEIHLSGKGHTGVGEDVTYETSHHESLQETGPPPMEGEYDLDTFSEIVGDLDLFPDDEPERESFRHYRRWGFESAALDLALKQAGETLASALDASYDPVRFVISTRLGEPPTADRVESLLADDPSREFKLDPTVEWDDDLVRTLADTDAVRITDLKGHYEGTDVDSPADPDLYRRILDGFPEAIVEDPAVTPETEPILDGEWDRLSWDAPFHDVTDLEDLPETGCLNLKPSRFGSIESLLEAIEHADREDKAVYFGGQFELGAGREHLHALASLVCPDAPNDVAPRGYNDPNYDGPLPASPLEPPTSPTGMEWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W132</accession>
    <name>R4W132_9EURY</name>
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        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydromethanopterin reductase</fullName>
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    </protein>
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        <name evidence="2" type="ORF">L593_11590</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447155.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11590"/>
    <dbReference type="EnsemblBacteria" id="AGN02261">
        <property type="protein sequence ID" value="AGN02261"/>
        <property type="gene ID" value="L593_11590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180804"/>
    <dbReference type="KEGG" id="sali:L593_11590"/>
    <dbReference type="eggNOG" id="arCOG02410">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="349" mass="39606" checksum="42ADA7ED697DC000" modified="2013-07-24" version="1">MQSRIEFGVHLNSHGEDIDTCIREAKTVERSGFDLLSLPDHLFSDAQPDWEVWTMLGVLAAETDEIDLMPGVADSVRRHPTHVAHATVTLDQATHGRARIGMGAGEAFNFRGIEDFDWSKPFTRFKEHVEVMLRLWESTEDDRVDYDGEYFQLDDAYLGFRSSQEPHPPLIHGGYGPKMRRFLGEVADGWLPWIHTPEKYEEDLDLIFESARESGRDPSDIRCSLMIPSAISETNPAKVEQDLVDKRASNLVLRPPLLESLGYPDLAEEAPIMWQMDHGEEKTAAIEDIVDQVAYEDILEIFIAGTPESAIEQIERFVDAGVDELVIIPEGDFTETIEHYRETIIPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1E6</accession>
    <name>R4W1E6_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">L593_12410</name>
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    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12410"/>
    <dbReference type="EnsemblBacteria" id="AGN02421">
        <property type="protein sequence ID" value="AGN02421"/>
        <property type="gene ID" value="L593_12410"/>
    </dbReference>
    <dbReference type="GeneID" id="16179925"/>
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    <dbReference type="eggNOG" id="arCOG06300">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197620_0_0_2"/>
    <dbReference type="OrthoDB" id="73607at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="237" mass="27005" checksum="D645942265FFFBB6" modified="2013-07-24" version="1">MRRVQYGDGDERLVFVLGWGNRPEHEGVQWLCEHLIDAGYSLDVFEIPRTISDFERQYLDPVEAHLADLETYRLLSHSTGGLITRYIPADESLLSRTYLSPWWGFHEDLQNPIVRWLSLLPVPWPILPASSDREDLGEYTTDERMADLPSFAAPTFLREARRAQRAMPPYDDRDAVFYTPDDPIVDAPTIERTVPEANRIAYDGGHELFNSESREEHLDAVLAAIDGGIAAVDDGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1I6</accession>
    <name>R4W1I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_12685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12685"/>
    <dbReference type="EnsemblBacteria" id="AGN02476">
        <property type="protein sequence ID" value="AGN02476"/>
        <property type="gene ID" value="L593_12685"/>
    </dbReference>
    <dbReference type="GeneID" id="16180123"/>
    <dbReference type="KEGG" id="sali:L593_12685"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102056_1_0_2"/>
    <dbReference type="OrthoDB" id="76153at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="20583" checksum="3122E76A7CE6C103" modified="2013-07-24" version="1">MSLPELPDGDQPATVLLLAPGFGDAGTAGCSGLFANSGAENLLYVTWSGDPSDRLAHAREHVDDVERARAVVVGDLSGPPSGPFDAVETVNAPTDLTGVGIAVTELLSQTEGSTAVCFDSVTALLQYVDLDTAFEFLHVFAGRLHRYDAVGHFHMDPGAHDPQVVAQVASLLDGKLVLDDDGDVEDAAASLRDWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2A6</accession>
    <name>R4W2A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14260"/>
    <dbReference type="EnsemblBacteria" id="AGN02791">
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        <property type="gene ID" value="L593_14260"/>
    </dbReference>
    <dbReference type="GeneID" id="16181226"/>
    <dbReference type="KEGG" id="sali:L593_14260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2919"/>
    <dbReference type="eggNOG" id="arCOG04566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055067_1_0_2"/>
    <dbReference type="OrthoDB" id="64670at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="288" mass="31431" checksum="482F1E9754669FE8" modified="2013-07-24" version="1">MASEDTGDLGGLAVSEDVRRWLQRTADEHGVDVEHFVRELLAAHHALDSDGTNLDAVEESIDRGELDSVREEFTELLEDVRSRVIQVKRETDAKAPADHDHESIESDLEALQSAIDDLDGDLEAHQERVESLGSAIDDGFENFEEVLEYLLETTDDLAERTDRLARATIGTRERVQEFAGTIEERAAADRLKRDAALEGIGSADCAECGQSVRAALLTAPECPFCAAEFVDLEPKRGLFGSATFQTGARPALTGADEDPVADELRSDVERDRPDPADVDWDAAGDDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H4</accession>
    <name>R4W2H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="15" type="ORF">L593_00085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444866.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00085"/>
    <dbReference type="EnsemblBacteria" id="AGM99971">
        <property type="protein sequence ID" value="AGM99971"/>
        <property type="gene ID" value="L593_00085"/>
    </dbReference>
    <dbReference type="GeneID" id="16180896"/>
    <dbReference type="KEGG" id="sali:L593_00085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.17"/>
    <dbReference type="eggNOG" id="arCOG01433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_2"/>
    <dbReference type="OrthoDB" id="24741at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="53"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGM99971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="427" mass="46101" checksum="EDA4AD1171672DA2" modified="2013-07-24" version="1">MSSDATFGEYGGQYVPEALMPAIEELTDAYERYVLENEDGFVDEFRERLRDFGGRPTPIQRADQLSERYDADVYLKREDLLHGGAHKLNNALGQVLLAKYMGKERIIAETGAGQHGTATAMACAHLDMPCEIYMGRTDVNRQRPNVFRMRINGAEVNPVDVGRGTLKEAISETMRDWAGSVEHTHYVIGSVVGPHPFPTMVRDFQAVISEEARDQLRERTGGLPDAVLACAGGGSNTMGTFHHFVPDDGSEAAPDGGDRVDLYAVEAGGSSLSVDEEAGVAPNSASLSTGEEGLLHGARTKLLQDSDGQIMESHSVSAGLDYAGVGPELARLVDDGRVSPVNVDDEAALEAFHRLSRTEGIIPALESAHALGFLEERIVEEGESLGDTILLTVSGRGDKDLETVIEESGDRNLDAAPSMDVFREGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2S8</accession>
    <name>R4W2S8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445021.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00860"/>
    <dbReference type="EnsemblBacteria" id="AGN00127">
        <property type="protein sequence ID" value="AGN00127"/>
        <property type="gene ID" value="L593_00860"/>
    </dbReference>
    <dbReference type="GeneID" id="16182207"/>
    <dbReference type="KEGG" id="sali:L593_00860"/>
    <dbReference type="eggNOG" id="arCOG02259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567083_0_0_2"/>
    <dbReference type="OrthoDB" id="115954at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043855">
        <property type="entry name" value="DUF5817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19134">
        <property type="entry name" value="DUF5817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5817" evidence="2">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="18300" checksum="85F2C9344181F537" modified="2013-07-24" version="1">MYAVVGCTECSSLWVIEQGGDSATCPRCGKRHQTKKLRHFAEAAEADDAREARAALVANRRGAGDAAPSFGDLEASIGEDVIDDETQLEAAGIDPEAVAEAGERASGGGGSRSRREIVLDAFDVHEEPDGAAIRDYAEEHGVPREYVDRALRKLEGRGEIVETRSGYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2T7</accession>
    <name>R4W2T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445036.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00142">
        <property type="protein sequence ID" value="AGN00142"/>
        <property type="gene ID" value="L593_00935"/>
    </dbReference>
    <dbReference type="GeneID" id="16182308"/>
    <dbReference type="KEGG" id="sali:L593_00935"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118414_0_0_2"/>
    <dbReference type="OrthoDB" id="83812at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="22733" checksum="19EE0C086B4C55E9" modified="2013-07-24" version="1">MDRRGIAIRAGLVAPPIALVGILLATLVDPDFTWLDSALSHTGELPPGRSISLSLIADRPSFLLFNGSLIVAGLGGLPFAWLLHDDATHPLQRSGAITLTVALVSLAAVGVFHLPHGWHAPSAIVHFLSTMGFLWLYGLGMAQVGDVRRGAVTALLGTIVLATWLLWTFALPDAGIAIPEFVGALALGGWILVEAFRKLEERERDAARAGLGNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4C8</accession>
    <name>R4W4C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445946.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01052">
        <property type="protein sequence ID" value="AGN01052"/>
        <property type="gene ID" value="L593_05515"/>
    </dbReference>
    <dbReference type="GeneID" id="16181896"/>
    <dbReference type="KEGG" id="sali:L593_05515"/>
    <dbReference type="eggNOG" id="arCOG03020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133603_3_0_2"/>
    <dbReference type="OrthoDB" id="126440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9390" checksum="CDC3B6B229779FA5" modified="2013-07-24" version="1">MVREVPLNESDELFEELSYPTDTATVRERFDDVVFQYADGEEALPDVLDRVGTDDFASADELSMELYSVLPVEAVGEPGQSEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4N2</accession>
    <name>R4W4N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CB"/>
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        <property type="entry name" value="DNA_brk_join_enz"/>
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        <property type="entry name" value="Integrase-like_cat_sf"/>
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        <property type="entry name" value="Integrase_SAM-like_N"/>
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        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="120"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="38677" checksum="EA3A3C686439065E" modified="2013-07-24" version="1">MATRNDDLEPIEPRTAQQLFLDHKETHCSDATVQAHRYKTNHFMEWCEENDVDNLNEISGRDVQTYRLWLQEKSDMKKITMRIHMSTMRVFFKWAGSVEAVPENLYDKVMVPSVSREDRKRDETLDTERAEEILEYLSTYEYASDRHVVMALLWNTGIRIGSAKSIDIEDIDFKNGHLELQHRPDEGTELKNGEGGERLIAISSDLAKLFGDYIDDIRIPIEDDHGRRPLLTTRRGRMSRATMRRLVYDVTAPCFFDDPCEDCKADIKGARCGGAVSPHSIRRGSITHYLSEDVPVDVVSERMNVSRKTLEQHYDKRSEEVKVEQRRAHLEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4T3</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="L593_06850"/>
    </dbReference>
    <dbReference type="GeneID" id="16181901"/>
    <dbReference type="KEGG" id="sali:L593_06850"/>
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    <dbReference type="eggNOG" id="arCOG02174">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MMPL_dom"/>
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        <property type="entry name" value="SSD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="464"/>
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            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="797"/>
        </location>
    </feature>
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            <end position="829"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
            <begin position="670"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="837" mass="89861" checksum="997D8C6A55C25129" modified="2013-07-24" version="1">MFDSLLDRTVAVVTTHSKVTIAVVLLASVVVGAGAADIPGPTEDDLASDSVEQEKLEYIQTNYGENTEDVVSVPVYVQNEGGNVLSKASLLRSLRFQRDVVGEETVREAAHPEQPVVGVSNRVAVRLAGDPQADLQTQIEALEGAEEAEVREIVVRVLQEEQQTLALLPRTYDGGTATAESRQMVFLLEGEPEEAFALTGPVADAQQVVFERTDEETEDDYFMLTGPALQELQAQATTDTLLFIGPIALLLILVALSFAYRDVLDVVVGMFGVVLTLVWMFGLLGWLNVPFGNASIIAPILLIGLSIDYGLHVFMRYREERGGEERTLAEAGERIDRDVRPSMDRALSGVGVALLLVTVTTAIGFLSNATSPLSDIRVLVVATALGVVAAFLVFVTIVPALKVEIDSLAERYGRDRRKPALGNDAGRVRDFLTLGVSAANRSAVTVVVVALLLTAGGVLAFGALDTSLAYEPDQPAQWQQDVPEPFGMEEFEYLHNQRYVEQNFARAGPGVSSGQILIEGNVTAPETQLRMARAQQRFAESGVAFERSDGATGVQSPITVMQAAAAENATFAATFEQADATGDGVPDRNVREVYHALFEVAPDRAAAVIERHDGEYRSARVVMPVRQDADFRESADAIRRSARTVDGAPGVTATPTGEDVILLVEMDVLTDNVLQTLYLALGVILLLIMAVYRRTKGSASLGAVTVLPIGMVVTWVFGAMWVFGVPLTLLTALLMSLAIGLGTDYTVHISERFAQEMERTSDATEALERATAGTGGALLGSTATTVAAFGTLALSTFPDVRQIGFLVAFALLCSFVVAVFVLPSILLVWTRLGGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W592</accession>
    <name>R4W592_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Nucleotide-binding protein, PIN domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_08235</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10130">
        <property type="entry name" value="PIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15269" checksum="5124E2952B72B246" modified="2013-07-24" version="1">MKLVVDANVVISALIADSKTRELIVTLEPDLLTPAFVSEEIENYEELIVEKSGMGPDRVAQFIDLLFQYVEVVPAAEFYPAIERADDAIGETDPDDVLYLACAIARDAAIWSDDSDFDEQDVVETFSTSNVIDSFDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5A9</accession>
    <name>R4W5A9_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Methyltransferase family protein</fullName>
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        <name evidence="3" type="ORF">L593_08360</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08360"/>
    <dbReference type="EnsemblBacteria" id="AGN01617">
        <property type="protein sequence ID" value="AGN01617"/>
        <property type="gene ID" value="L593_08360"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08360"/>
    <dbReference type="eggNOG" id="arCOG04734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071501_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="64"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="25952" checksum="4E8F1E17D76D8BEE" modified="2013-07-24" version="1">MVADYHRDALAGQPTYERSDGDESTAQCAWYFAGPEDWGSLETTVIEACAAAPPGQSRATPRVLDAGCGPGRALGPLADRGADVLGIDESPGAIQVAREWTGQPAIVGDLATPPLASDAFDAALFLGTHVGTGGSISALRDLLAELDRVLAPRGRIVADMYDPTAVEAEDLSEYLDGRWLADGVATRRFRLRYDGTAGRWRTLLMASPDALETIVAPTSWSIGRVERDEGTRHLFVLERGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5J4</accession>
    <name>R4W5J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446651.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01757">
        <property type="protein sequence ID" value="AGN01757"/>
        <property type="gene ID" value="L593_09060"/>
    </dbReference>
    <dbReference type="GeneID" id="16182610"/>
    <dbReference type="KEGG" id="sali:L593_09060"/>
    <dbReference type="eggNOG" id="arCOG14272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2857003_0_0_2"/>
    <dbReference type="OrthoDB" id="125590at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="7288" checksum="1EC32B4126279A4D" modified="2013-07-24" version="1">MDEASYVVERLSGEERGIRVTCSAHDESEEFQPGQNRVAFYCSGCGLEIEAAIHADDWRDMGEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5K2</accession>
    <name>R4W5K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446666.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09135"/>
    <dbReference type="EnsemblBacteria" id="AGN01772">
        <property type="protein sequence ID" value="AGN01772"/>
        <property type="gene ID" value="L593_09135"/>
    </dbReference>
    <dbReference type="GeneID" id="16182648"/>
    <dbReference type="KEGG" id="sali:L593_09135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1873"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_2_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="32213" checksum="A2C093B4371659DF" modified="2013-07-24" version="1">MAVQRVAVTGGNGNIGEAILRELADHGYETVNLARGKRREAVSDEYQSIDLLDAGAVYGSLARTGVDAAIHMGTIPSPSRNPGHETYRSNVQSAYHVLEAAEALGIGRVVVPSSVNVMGAAFQDAKIEVEYLPVDEEHPVTPRDPYAVAKHAMEVTADGVARRPDGPTIASLRYPWVADGDDLRSAFEEWSTDLAAMRGERSRTTRDVLFSYLHLKDAASVARRALEADIDGHERFWAVASDTCVRTDSERLVEEFFDHAERREPITGTDPLVTTAKAERLLDWEPGWSWRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W607</accession>
    <name>R4W607_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446936.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10485"/>
    <dbReference type="EnsemblBacteria" id="AGN02042">
        <property type="protein sequence ID" value="AGN02042"/>
        <property type="gene ID" value="L593_10485"/>
    </dbReference>
    <dbReference type="GeneID" id="16182508"/>
    <dbReference type="KEGG" id="sali:L593_10485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2161"/>
    <dbReference type="eggNOG" id="arCOG01566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_0_2"/>
    <dbReference type="OrthoDB" id="25036at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="63"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="264"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="389" mass="41274" checksum="60D8703D464D5672" modified="2013-07-24" version="1">MQFEQAAGVVGQVDAVSGIDPLLIAAAVVVVLVVVAVTSWTFLRFRRSPGERFQKALAGSEEVAILTHPNPDPDAMACAMGAARIAEFAGVDATIQYAGQIRHQENRAFRTVLEFEAEQIEAKSDVACDDVVLVDHNVPRGFPGAEGVEPIAVVDHHPGNGVGTRFTDVRPERGSCASIIADYFQDLGADRYGPEDTPPEDGGLYVDAPLATGLVFGLQSDTNRLTEGATQADFDACSYLYPSIDSDLLERIADPEVTAETLDVKARAIQNRQIDGSFAVSHVGEITDADTIPQSADELVRLEGVGAVVVMGERDGVLHLSGRSRDDRVHMGEALEAAVESVPMASAGGHARMGGGQLSIDHMEGIGPSAGMDVPQLTERLFDCLRGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C6</accession>
    <name>R4W6C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445192.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01725"/>
    <dbReference type="EnsemblBacteria" id="AGN00298">
        <property type="protein sequence ID" value="AGN00298"/>
        <property type="gene ID" value="L593_01725"/>
    </dbReference>
    <dbReference type="GeneID" id="16182268"/>
    <dbReference type="KEGG" id="sali:L593_01725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.350"/>
    <dbReference type="eggNOG" id="arCOG04634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_2"/>
    <dbReference type="OrthoDB" id="12175at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="666"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="746" mass="81558" checksum="8F86FE0F362FA270" modified="2013-07-24" version="1">MSESEARHPYEDPSLSTEARIDDLLDRMTLEEKAGQLVGMPLGNFERGRDVDEAKELVDEHHLGSVAPFGWGGAFYWTPDECAEVARELQEYAREETRLGIPLLFNADAVHGHAYVKGATTFPNGLGMAATWDTELTKRAGEVTGRELRATGIHQNYGPTCDVGRDPRWGRAHETYGESPYLVKELIGAEVTGLQGEHGNVDDESVIATAKHFPAYGEPRRGEDAAPVEISNSTLRRVFLPSFEAAVEADVWSVMPCYNSIDGEAVHGSRRFLTELLREELGFDGHVVSDWGGVDHLQNDHKVTPDDEASSRLTRQAGLDVISVGMGRHAEHTVDLVESGELSEDRIDESVRRVLRAKFELGLFEGETADPEEAEATLRDEEHVQLSRESIQKSITLLQNDGDVLPLDDPDEIFVGGPNADDLIAQIGGWSIMDEEGVPGKTIREGLESVTDAEITYERGAGVAEYDDVEAAAEKAAEADVAVVAVGEDWYIHEFGPQQDAGHPTGEFPTRTELELPDPQIELVKAIQETGTPTIGLLVTGRPLAIPWMAEHLDALMMTYFPGSEGGEVVAEALTGEIEPAGRLPVSIPKSSGHLPTYFNYLRHPRPIGDDEHTDSYDPLFEFGHGLGYSEIETTGLSLSADAIGPGETVDVEVTVENVGDRASSEVVQLYVTDEWSTRVTPIRELKGFQRVEVDAGDTATVTLELSGEELGVVGPDTPHHVEDGVFELRVDDLEAELTVESEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C7</accession>
    <name>R4W6C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447116.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02222">
        <property type="protein sequence ID" value="AGN02222"/>
        <property type="gene ID" value="L593_11385"/>
    </dbReference>
    <dbReference type="GeneID" id="16181093"/>
    <dbReference type="KEGG" id="sali:L593_11385"/>
    <dbReference type="HOGENOM" id="CLU_2056151_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12467" checksum="277D854A93B66E62" modified="2013-07-24" version="1">MSRLLDRHAPYALPLVVGRLADTVTTLYGLRIAGIYERNAVVAALMEDLGRTEGMLVANVISIAIVLLTVEIGVALVASDDGPGELQLSERVVVEVGYLPAIGLSFAAATYNVGVIAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F8</accession>
    <name>R4W6F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase, diketogulonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445252.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02035"/>
    <dbReference type="EnsemblBacteria" id="AGN00358">
        <property type="protein sequence ID" value="AGN00358"/>
        <property type="gene ID" value="L593_02035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180032"/>
    <dbReference type="KEGG" id="sali:L593_02035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.414"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="27639" checksum="5D797E62A108F3CC" modified="2013-07-24" version="1">MDFPRLGLGTMGIDDPDAVTTAIDLGYRHLDTAQIYDNEAVVGEGIDQAGVDRDDLLVATKLWIDQLDRVRESTVESLDRLGLDSVDLLYVHRPKGAYDPESTLSAMAELRDDGLIDGIAVSNFEIGDLDRFADVLGEPPAANQVEYHPLFQPEDRLEHAREHDYPLVAYSPLSGGEVDTVEPIVEVADRHGITPEQASLAWLLAKGIHPIPKASSREHLEANRAALDVELTDEDVAAIDAVEREHELYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G6</accession>
    <name>R4W6G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447196.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11795"/>
    <dbReference type="EnsemblBacteria" id="AGN02302">
        <property type="protein sequence ID" value="AGN02302"/>
        <property type="gene ID" value="L593_11795"/>
    </dbReference>
    <dbReference type="GeneID" id="16181248"/>
    <dbReference type="KEGG" id="sali:L593_11795"/>
    <dbReference type="eggNOG" id="arCOG08150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114809_0_0_2"/>
    <dbReference type="OrthoDB" id="85128at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="21442" checksum="B74D0743D93AD559" modified="2013-07-24" version="1">MADDSDLAAVFEQTRSLSEKETLSPEEYQAIKRAVFGEVFQGILQAETSYFVLGRYDGDETEARLEAVTARLNDRDDAFAYLMKDVPEAWEFWPTKFRILAERADLIVPVLEDTDGSHEWEFGVVSGPEYRSKVHVLKREYPTEAEEHEHFDALPSQFVDVLDRDGRVTRWTTEAELLAALEHLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H5</accession>
    <name>R4W6H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02322">
        <property type="protein sequence ID" value="AGN02322"/>
        <property type="gene ID" value="L593_11895"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11895"/>
    <dbReference type="eggNOG" id="arCOG09219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1623527_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="163" mass="17779" checksum="7C75EF82A1670BA6" modified="2013-07-24" version="1">MAGLIAGTAGCLDLGGQSDSVSDEPFSSYTCPPEGIDAEGRELWCSHTADADDRELVLEPSVEQSPNPSEVRLHLTNESETSMRFNPASWSIWLEQSGEWRALEQTWVGDGFADLGPGQTHEWGFEEVIELINDRFDPEPATYLAAIATPRGSPAALLRITDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P1</accession>
    <name>R4W6P1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_02735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445392.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02735"/>
    <dbReference type="EnsemblBacteria" id="AGN00498">
        <property type="protein sequence ID" value="AGN00498"/>
        <property type="gene ID" value="L593_02735"/>
    </dbReference>
    <dbReference type="GeneID" id="16180319"/>
    <dbReference type="KEGG" id="sali:L593_02735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.554"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="OrthoDB" id="31195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="37789" checksum="C480DF9E82DF91B6" modified="2013-07-24" version="1">MESPLWTERHAPAIEDLRQDLARDQFERAVDDPVNLLVHGPPGVGKTAATRAMAREAHEQPDSDLIEINVADFFARTKTEVKNDDRFASFLQGKSDYSKRDMINHVLKESASYAPVTGEYKTVLLDNAEGIREDFQQALRRVMEQYHRNTQFVIATRQPSKLIPPLRSRCFAVPMPAPDTDEVADVLEEVAVAEDVEYERDGLEFVAGSANGDLREAILSAQTTAESEGEITMNAAFEALEDVGLDDRITEMLDAAEAGEFTDARSELDDLLVDEGLSGREILEEVLSVGRSRYDGDRLAELHELAGDVDLDLTEGSNDRIQLGHFLAELGRPDEAQTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W719</accession>
    <name>R4W719_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Aminopeptidase ( leucyl aminopeptidase, aminopeptidase T)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447536.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13515"/>
    <dbReference type="EnsemblBacteria" id="AGN02642">
        <property type="protein sequence ID" value="AGN02642"/>
        <property type="gene ID" value="L593_13515"/>
    </dbReference>
    <dbReference type="GeneID" id="16180690"/>
    <dbReference type="KEGG" id="sali:L593_13515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2766"/>
    <dbReference type="eggNOG" id="arCOG01890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062630_0_0_2"/>
    <dbReference type="OrthoDB" id="48170at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="33036" checksum="83CA4F0BC640D2C4" modified="2013-07-24" version="1">MPDLQSPAETAIQDCLAVGSDESVAVVTDDERLPIGEALYDVASEVTADATLVRYQPGDQHGAEPPAPVSGAMADSDVFVAPTTKSLSHTRARSRACDDGARGATLPGITEDVFTTGLGADYESIARECEQMLDHVAGAEEIRIETELGTDFTVRPGERSWNADTGLVHEAGDFSNLPAGEVFVSPETAEGTYVVDGTMMPHGLLEDDQTLRFEVDDGYVTEISDPEIREQVETAAAEVGDAAYNLAELGIGTNLAVDSLVGSVLLDEKAAGTIHIAIGDDAGIGGDTEAPLHLDGIVRDPTVYVDGEPIELPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W739</accession>
    <name>R4W739_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13715"/>
    <dbReference type="EnsemblBacteria" id="AGN02682">
        <property type="protein sequence ID" value="AGN02682"/>
        <property type="gene ID" value="L593_13715"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2805"/>
    <dbReference type="eggNOG" id="arCOG08235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="343" mass="35486" checksum="24EEA88AFCA7E7AF" modified="2013-07-24" version="1">MDRLRKIFNRQIGVCYSMAQTRRRWLAALAASASLAGCIGDGDSDGGSESDGGGKVYGTTTGSGDDGSDGDTADDENTSEDGGTGRAAASIQTSDHEQLGEILVDGDGTTLYMFEPDPQGEGSSTCSGDCAAAWPPLTTETNPESGDGVTASLATFERSDGSTQVAANGWPLYYFAQDSEPGDVAGQGIDGFGGYWWVLRPDGTPVRPDVQIREHSDLGNILVDGEGMTLYMFDSDSQGSGSSACSGGCADAWPPLTVEEEPMAGTDLDAELTTFDRSGGSTQVAANGWPLYNYAQDSEPGDATGQGVQDGWWVLDPSGAPIRDIGGSSEGDFGGSSDDETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W758</accession>
    <name>R4W758_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445652.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04035"/>
    <dbReference type="EnsemblBacteria" id="AGN00758">
        <property type="protein sequence ID" value="AGN00758"/>
        <property type="gene ID" value="L593_04035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180822"/>
    <dbReference type="KEGG" id="sali:L593_04035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.820"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="67630at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="262" mass="28556" checksum="F49D051D43F884B0" modified="2013-07-24" version="1">MSGSTESGAAHRTDTAVSLRGVGKTYQTAQPVRALHDVSFELPRGSYTAVMGPSGSGKSTLMNLIGCLDTPTEGTIVIDGQDVTALSDRERTRLRGEEIGFVFQTFNLMPRLTALQNVALPMVARDASRTARRERARSLLEQVGLGERLDHLPNELSGGQRQRVATARALVNDPTLLLADEPTGNVDTTTGDTIMRLFSELHAAGNTLLVVTHERRIGEHADRILHLLDGELERIEVVESPRRPTVDAGSNDRRRDGDREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A7</accession>
    <name>R4W7A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_020445752.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04535"/>
    <dbReference type="EnsemblBacteria" id="AGN00858">
        <property type="protein sequence ID" value="AGN00858"/>
        <property type="gene ID" value="L593_04535"/>
    </dbReference>
    <dbReference type="GeneID" id="16180982"/>
    <dbReference type="KEGG" id="sali:L593_04535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.925"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
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    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
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    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="44249" checksum="AAE6A50C1ED4E63C" modified="2013-07-24" version="1">MTGEAPTGGTVALEDAPLPTIAVDIVDGTPRIAGVNEPFRSRFGDVTVDSRLHDALTAAGFDVDDGALTPARLESGLRQSIRRTNEDESSSGAGDSHVLLSIPVSEGGALVVLLADVWAGPGPGPGRGESDARTDATAVANGEDRGKADPTTEQSLAAFASAIGHDLRNPLDVAKARLRAGRERADDEHFEHVERALDRLDRRIDDVVALADTGAADRTESIDVGAVAERAWADCRTGRARLAVRGPFPAVEADESGVRRIFENLFRNAVEHGSTSLHSAHPREDAVEHGSTSPRSKSSREDAADHGLPPEAGGEKHPGARVADDGSPAELTVTVDRLTDPDGFSVEDDGSGIPEDIRDRLFDPGVSGEEHGTGLGLAIVDRIADRHGWTVAATTGDDGGARFEIVGVDFDADDTLSESDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R7</accession>
    <name>R4W7R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444893.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00220"/>
    <dbReference type="EnsemblBacteria" id="AGM99998">
        <property type="protein sequence ID" value="AGM99998"/>
        <property type="gene ID" value="L593_00220"/>
    </dbReference>
    <dbReference type="GeneID" id="16181108"/>
    <dbReference type="KEGG" id="sali:L593_00220"/>
    <dbReference type="eggNOG" id="arCOG04546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1405952_0_0_2"/>
    <dbReference type="OrthoDB" id="92895at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="22215" checksum="2368AB20C901752E" modified="2013-07-24" version="1">MQFRLLGWPEDSPRLDLDHERFAYAGNYVTGRTGIAAALAADADPTAAPIESQRDDEPWSPSEDAVLAVASFDEDRAADGALRIRYVSVRTDHRDGGIGPRLLAFVVDRALERGYDRVRIGVNNPIAYQAGYRAGFAFTGEESGMGELVLEAPAPDPSTEQYRDGFDRFADRDLPVEQQSVVERHRDGQPPDVIDPETPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U1</accession>
    <name>R4W7U1_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Sugar ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00595"/>
    <dbReference type="EnsemblBacteria" id="AGN00074">
        <property type="protein sequence ID" value="AGN00074"/>
        <property type="gene ID" value="L593_00595"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.121"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="39631" checksum="56474039A9DDA3BB" modified="2013-07-24" version="1">MTRISMRSVSKYFDGGDTVANYKLDLEVEDGEFLVFLGPSGCGKTTALRMIAGLETPSEGEIYFDDDRVDRDPPADRNVAMVFQNYALYPHMTVRENIEYPLKVRGIPPEERDERVAETAELLHIEDQLESDPAEISGGQRQRTSLARAIVREPSVFLLDEPLSNLDAKLRLEMRSELKRLQNELDITTVYVTHNQEEAMSMGDRIAVMNEGTIRQVAEPEELYRRPQTTWIANFIGSPPMNLFPGHRRNGSIDLDSGDTVPAKNETESDDVSLGIRPEDMVVTTEPPESEWSIKGTVETVEPLGEYVLVNVDVSGELINVKVPTTEVEPGTTVYLTFEPEDAYLYDGDGILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V5</accession>
    <name>R4W7V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446122.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06405"/>
    <dbReference type="EnsemblBacteria" id="AGN01228">
        <property type="protein sequence ID" value="AGN01228"/>
        <property type="gene ID" value="L593_06405"/>
    </dbReference>
    <dbReference type="GeneID" id="16181728"/>
    <dbReference type="KEGG" id="sali:L593_06405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1305"/>
    <dbReference type="eggNOG" id="arCOG08979">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048530_0_0_2"/>
    <dbReference type="OrthoDB" id="13268at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="446" mass="51877" checksum="775EB7760833C48C" modified="2013-07-24" version="1">MDRAELIDSVAEDLFAYVMHGTMPETHVAEQIKPNGLDERFEDFDALVDLHFILKPEVIDFVEALPHRIRSIKTQTKNVSTASRGEIDGRIDWESTMTTRASSAPGDRSLFVCDTRHESYDVDENVVLKRLLSLIYTTLDDAEYYLKQEYDWVTDRWQENLELVDRMRDLFERNVHVTRIRAPERYEPTDRMLQRADGARNEIYREAAALLRDHQASRRGDVDAIRTLLADTAITPGDEETLFELYVLFQYVNAIEDHKDGDATVSTIQTDRQEVARIESEDGSDVVLYHDNSGRDDISFITHPREKAESDLTRSERIYHETQKITNRYFKDSDFQVRSNRPDVIVLEIQRDDQYEYLVTEVKNSIGRRTIRNGITETLEYLAFLRRDDQLVYEEETPFGTGWNGVLVVQDMEEQDTASLHEQETIRILQASELDTAIPELLERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W6</accession>
    <name>R4W7W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446157.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01263">
        <property type="protein sequence ID" value="AGN01263"/>
        <property type="gene ID" value="L593_06580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181815"/>
    <dbReference type="KEGG" id="sali:L593_06580"/>
    <dbReference type="eggNOG" id="arCOG09101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323985_0_0_2"/>
    <dbReference type="OrthoDB" id="96171at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="20840" checksum="2AA17D1EFCA13C35" modified="2013-07-24" version="1">MPDCDYCEQSFPDEGSLLEHMGEAHEGELGRIDQRRVADHYGGDGEGLSTTIVYAIVGIVVVGVIGGAVYAAVGAFSGGPAQPVHEHGTINMTVNGERLAFDEPQHTASGAFHFHDSGPTWHMHPSEPGRLTLAEAMQDVGIDLTESTVTVDGTTYRASDDGTTVTIRVNGEPVDPTAYELHEDDHVRIVVDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W850</accession>
    <name>R4W850_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis protein MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446387.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07740"/>
    <dbReference type="EnsemblBacteria" id="AGN01493">
        <property type="protein sequence ID" value="AGN01493"/>
        <property type="gene ID" value="L593_07740"/>
    </dbReference>
    <dbReference type="GeneID" id="16182208"/>
    <dbReference type="KEGG" id="sali:L593_07740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1586"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_0_2"/>
    <dbReference type="OrthoDB" id="86909at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="273" mass="28655" checksum="5CB02308B8A24FEB" modified="2013-07-24" version="1">MSDLDLGPEQLERYARHVVMDDVGPEGQAALLDASVLVVGAGGLGCPAIQYLAAAGIGRLGIVDDDVVERSNLQRQVLHGEADVGRPKVESAAEAVASLNPDVTVDRHETRFTAENAMALVSDYDVVLDASDNFPTRFLVNDACVLAETPFVHGAVYRFEGQLTTVAAGGRPCYRCLFPEAPPEGTVPNCATAGVLGVLPGTIGAMQATEAIKLVLGVGDPLTEAVVYYDARNPGTETVDLRPRPDCPVCSADAEIRDVADVTYEGGCTVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W886</accession>
    <name>R4W886_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446462.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08115"/>
    <dbReference type="EnsemblBacteria" id="AGN01568">
        <property type="protein sequence ID" value="AGN01568"/>
        <property type="gene ID" value="L593_08115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180112"/>
    <dbReference type="KEGG" id="sali:L593_08115"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093378_0_0_2"/>
    <dbReference type="OrthoDB" id="97382at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="19920" checksum="8D74A935AF509B97" modified="2013-07-24" version="1">MATSEAGANGPDRDEVFDLLSNHRRRYTLHYCKQAEEPVTTSDLAETVAAWELDKEVNELSSDERKRVYTSLQQTHLPTLADAGMITYEDHEVELTDDARKLEVYMDIVPEGEIPWGIYYLGLSAVGFAVLGGVWADILPSDGVSAIGWAGIVVGLFAVSAAAHTYTSRRHRLGDRERPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W893</accession>
    <name>R4W893_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445333.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02440"/>
    <dbReference type="EnsemblBacteria" id="AGN00439">
        <property type="protein sequence ID" value="AGN00439"/>
        <property type="gene ID" value="L593_02440"/>
    </dbReference>
    <dbReference type="GeneID" id="58789326"/>
    <dbReference type="KEGG" id="sali:L593_02440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.495"/>
    <dbReference type="eggNOG" id="arCOG06339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714994_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="42190" checksum="564895748EEAD745" modified="2013-07-24" version="1">MTSRHEFAAPTRRTLLTAIGTGIGAGVIGTSATGDEHQETNYALVQGDDCVPIQPVVGDRPVRSRYEYRLPERYVSEENGAVPGETGLYSSEGTTDLQEAKTSIAFLYRGPEGLSLVLVHGSATEPDGGSVTFRFAGLPEDGEWLVKDDLYRDPATGEIAAQNYDHWNVSGTEHRIDWTWGSSGTDGGAFGNLGDEFDLAIAPAFNEAAALYGEHYEGTVTAWEFCSGSDGGDRIALDMDEPIRITTARCGSEDDSDRDASDHRGNRGPPDHAGEEGPPDHAGEEGPPDHAEEEGPPDHAGEEGPPDHAGEEGPPEHAEEGGSDDRNRGRDRPGHSEEDDEEDDDEVEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G5</accession>
    <name>R4W8G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445528.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03415"/>
    <dbReference type="EnsemblBacteria" id="AGN00634">
        <property type="protein sequence ID" value="AGN00634"/>
        <property type="gene ID" value="L593_03415"/>
    </dbReference>
    <dbReference type="GeneID" id="16180536"/>
    <dbReference type="KEGG" id="sali:L593_03415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.691"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OrthoDB" id="52310at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="273" mass="29240" checksum="0058FC14E5FF6270" modified="2013-07-24" version="1">MFPGATADRAEAGFAVVGAPLDASTSFQPGTRFGPDRVRQFARPFEDYDHHTDQHFSDLGVHDHGDVRAWPNSAEYLDFLEGELAAFHDEGTVPLTIGGEHAVTVAVVRAVEPDVVVSLDAHLDLRESYDGDELSHACAMRRALETAEEVFVLGARAGSEAEWERAARDDVTVVEPADVADWSPPAAFGSDDRSVYLTVDVDVLDLAFAPGTGTPEPFGLDSATVHDVVRAIAPLAEGFDVVEVNDRDDGQAASVAAKLLRAFVFAHAAMDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S1</accession>
    <name>R4W8S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase, c-terminal domain of histone macro h2a1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445768.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04625"/>
    <dbReference type="EnsemblBacteria" id="AGN00874">
        <property type="protein sequence ID" value="AGN00874"/>
        <property type="gene ID" value="L593_04625"/>
    </dbReference>
    <dbReference type="GeneID" id="16181028"/>
    <dbReference type="KEGG" id="sali:L593_04625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.945"/>
    <dbReference type="eggNOG" id="arCOG04225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_1_2"/>
    <dbReference type="OrthoDB" id="78043at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="17778" checksum="88B05272FE5594B4" modified="2013-07-24" version="1">MEFRVVQGDIAAKSADALVNAAGTSLQMGSGVAGALRRGGGEALNEAAVAEGPVDLGEVAVTDAFDLDAEYVIHAAAMPHYGDGEATARSIRSATRNALATAESLGVESLVMPALGCGVAGFEYEEGVGIIAEVLDSWESETLDDVRLIAYADEEYEAMRRVAGAYDGYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X0</accession>
    <name>R4W8X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="8" type="ORF">L593_05275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05275"/>
    <dbReference type="EnsemblBacteria" id="AGN01004">
        <property type="protein sequence ID" value="AGN01004"/>
        <property type="gene ID" value="L593_05275"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1077"/>
    <dbReference type="eggNOG" id="arCOG01166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="247"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="566"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="759" mass="79369" checksum="AC2842756F4DCE16" modified="2013-07-24" version="1">MTEDADEQSSSSPGSQTRQDADEPDSPADTEIRPLDDDTIAKIAAGEVVERPASVAKELVENALDAGATRIEIAVEEGGLDLVEVRDDGVGMTEADCRAAVREHTTSKLSDAGELHAVETLGFRGEALHTIGAVADLEITAKSNPDRREADAATESDSGTRLVYRGGDVETVEHAAHPGGTTVAVTDLFHNTPARRKYLSEPATEFRHVSRVVGRYALANPDVAISFSHDGREVFATTGDGDRVAAIMAVYGREVAESMIEVDADPDTDAVDRIVGHVSDPETTRASREYLATYVNDRAVASDTVRGAIVEAYSGQLSAERYPFAVLFVEVPPERVDVNVHPRKQAVRFDDAGAVEDAVIDAVRDALLEDGIIRASAPRGVSKPAEARVDPGDGDQSDAADSDAADPDPAESDATDSDADDSAAAAAGSAPPSTGSTDAPTTPSAEEGSTTAEGAESDGSRSAPRSTGATDPERSDAADRTHAADRTDAVDRSDTAESSDPASGSGSGSAPLGDPSHSATPEAGDWTARLGSPIDSSVTATDQQTLDGESVSASSTEFDSLPPLRVLGQHAETYVVAAAPDGLVLIDQHAADERIHYERLRDAVDSGTAQALATPVELSLTPTEAETYDTYAPALKRLGFHADREDRTLTVRSVPTVLGETLDPDAIRDVFGALLSGGDGEGTVEAMADELLGDLACAPAVKGNTSLTEGSVTALLEALDACENPYACPHGRPTLIRIDGDELAERFERDYPGHGTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X3</accession>
    <name>R4W8X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445908.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05325"/>
    <dbReference type="EnsemblBacteria" id="AGN01014">
        <property type="protein sequence ID" value="AGN01014"/>
        <property type="gene ID" value="L593_05325"/>
    </dbReference>
    <dbReference type="GeneID" id="16181322"/>
    <dbReference type="KEGG" id="sali:L593_05325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1088"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_2"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026456">
        <property type="entry name" value="GCTrfase_AglJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04182">
        <property type="entry name" value="glyco_TIGR04182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="308" mass="34036" checksum="83D3C8285450F767" modified="2013-07-24" version="1">MTEDVTVMIPTLDEAATIGDVVEGFVERGYEHVLVIDGGSSDDTQEIAREAGARVIEQSGTGKGDAMMQGFAQIDTEYVLVLDGDGTYLPKDAEALLEPLRSGEAEHVVGNRFADIQSGAMPRLNQVGNKLINWAYRTIHQREHYDILSGYRAMTVDSLDRMNLSAEGFGIETEMCVECVRHGIDSMEVPITYETRPAGSETNLHPIKDGGTIIVTLYRLAKTNNPLFYFGSFGTVALLTGLAIASYVGYDWFVNRVPHEVLAVVAAAGILVGIQLIMFGFLSDMIVALHRDQRRRIERVERRFDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y2</accession>
    <name>R4W8Y2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl32e</name>
        <name evidence="8" type="ORF">L593_11190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11190"/>
    <dbReference type="EnsemblBacteria" id="AGN02183">
        <property type="protein sequence ID" value="AGN02183"/>
        <property type="gene ID" value="L593_11190"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11190"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2308"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_L32e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="HhH1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="34980" checksum="F7B372E0B5F10F41" modified="2013-07-24" version="1">MSDPSSIEDIAGVGASKADALREAGYESVEDVRAASADDLSEVDGIGNALAARIKDDVGDLEVDDEPEGDVESDELASEEADEEDSASSDAAAEEAEEDDRELDDISGVGASKADALRDAGYTTIQEVRAASQSELSDVEGIGNALAARIKADVGDLDVEAEPEGEVEDEAPEAEAEDVETELQPRGHADKTPDLSDEEERLLQRRAAVSTPQFNRQDYHKKKRVPTSWRAPRGGLSKQRRGIKGKGDTVEAGFRSPEAVRGRHPSGFEEVRVHNPDDLEGVDGETEAVRIASGVGGRKRERIEDEAEEAGIRVLNPTYEEVEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z8</accession>
    <name>R4W8Z8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445983.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05700"/>
    <dbReference type="EnsemblBacteria" id="AGN01089">
        <property type="protein sequence ID" value="AGN01089"/>
        <property type="gene ID" value="L593_05700"/>
    </dbReference>
    <dbReference type="GeneID" id="16181470"/>
    <dbReference type="KEGG" id="sali:L593_05700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1167"/>
    <dbReference type="eggNOG" id="arCOG08138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942002_0_0_2"/>
    <dbReference type="OrthoDB" id="45782at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="304" mass="32480" checksum="A575ADA5ABF27FB4" modified="2013-07-24" version="1">MDVDCEGCAGCCVDWHALAPGIEDPEREGERQPLDASTNFVPLERDEVRAMLAAGHGDALRPRLWTIDGAETTAGDADSASAEAADRPDAPVEVDGYPLAGIRGRPVFYVGLRKPPKPVAPAGRDEAVWLPTCTFLDPETLQCRIHDSELYPNACAAYPGFNLLLDQPTECERVEESGGGKRLLDDEPPADPPGVGLGPQALGAKLFAHPEPESLTGRIERLANGNGTRADRRAFVTVAASSSPGTLAVSEDWRERAREEFDAGDSWVSGSIDEWTELEGGDAAPTLGEQVEVERGAPDTPGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W913</accession>
    <name>R4W913_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HTR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_11575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11575"/>
    <dbReference type="EnsemblBacteria" id="AGN02258">
        <property type="protein sequence ID" value="AGN02258"/>
        <property type="gene ID" value="L593_11575"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2386"/>
    <dbReference type="eggNOG" id="arCOG02389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="436"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
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            <dbReference type="PROSITE" id="PS50110"/>
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            <dbReference type="PROSITE" id="PS50113"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02258.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="649" mass="72522" checksum="FBF529986A924DA8" modified="2013-07-24" version="1">MRILHVDDEVGLVELAATFLEREDDRFVVETATGASEGLELLDDDVDCIVSDYDMPGTDGVAFLEAVREDYPELPFLLFTGKGSEEVASEAISAGVTDYLQKETGTSQYTVLANRIANSVEQYRSMRELESSRRRLDLLFEQSPLGVVEWNEAFEFERLNDAAEEILGYDESALLGESWTRIVPESQEREVSEVTEAVLRDEGGYHNVNENRRADGTVIVCEWHNRVITDEAGDVVTMVSLFQDVTERKEREWQLERHRENLEGLHEAANRLYVADSAEECYDVMIDAAVTILGFDWCTLAAPAEDDEEMFEIQAISDGAPLELGDRPFGVDEGVAGHVYQTKEASVVQNAQDSDQGEPTNDEIRAALTVPVADWGIFQAVATSRGAFDEQDRRHAELLVSSMLATIDRLEQQTELRERQRELERQNDRLDEFASVVSHDLRNPLSVADGRLELARDAIEAEQRTGDQRIGDDWAAVAEHLDAVERSHDRMQSLIDDLLALARHGETPTELSPVHLATLVDDCWAAVETADASLETDIDLRIRAEDTRLRQLFENCFRNAVEHAGPSVTVTVGELDDSDGFFIEDDGPGIRLEEREHLFDFGYSTSEEGTGFGLSIVAEIVEAHDWQIEVLDGSDGGARFEVSDVRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W963</accession>
    <name>R4W963_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
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            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_12420"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="146"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="204"/>
            <end position="227"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
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        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="365" mass="40011" checksum="86C869A024C2AEBD" modified="2013-07-24" version="1">MDAFATNDGDRLLWIAVGVVVAFLIVLALFRFIGTFVAAVFLYYATRPIHRRIDERVARPNLAVALALFVVLVPMALVVGYALFLIAEELAGLVSGGAFSSLEPYLQPYLRLARRGEFRALGEAISQSGGSGTSASGRLQTLGDSIFDVASLVFGVIAKVFLLSAFLFYLLRDGSDVRDWFYESVDHDERIVAFTQAVDEDLEIVFFNNFVLVVLTSIEAAVFYYAMNLLVPGDPIVETPVLLGALIGIGTIIPVVGMKIVYLPYAAVLFVQAATTDTPLWHPLVFLGVSAIVIDTIPDVFIRTYLSARSSIHMGLILLGYVLGSMAFGWYGLFLGPIVVVIFYHFAHTTFPWLATAYLEGDSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B3</accession>
    <name>R4W9B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446238.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01344">
        <property type="protein sequence ID" value="AGN01344"/>
        <property type="gene ID" value="L593_06985"/>
    </dbReference>
    <dbReference type="GeneID" id="16181955"/>
    <dbReference type="KEGG" id="sali:L593_06985"/>
    <dbReference type="eggNOG" id="arCOG03021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133603_1_1_2"/>
    <dbReference type="OrthoDB" id="121854at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11132" checksum="2BFFF398F0EA238E" modified="2013-07-24" version="1">MELNDLPDHFAAELDFPVEKETAREAVGDVEVEAPDADHSVPVESLLEDLGEDSYESADMLYQTLSGQLPDEFIGRKFYDDRGPNVEHDESPKDGGDESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D3</accession>
    <name>R4W9D3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_13170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13170"/>
    <dbReference type="EnsemblBacteria" id="AGN02573">
        <property type="protein sequence ID" value="AGN02573"/>
        <property type="gene ID" value="L593_13170"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2695"/>
    <dbReference type="eggNOG" id="arCOG01091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111441_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="20769" checksum="236F40962EF32B48" modified="2013-07-24" version="1">MKRVPGSRRQILRDLLADEAVRSISRRYFVSNGFDGTLTCIGIVVGAVLSGIPDGLTVIQIGLGAAVGLGTSALWSVWEIERAETKAEILRLERAMLIDLDDTRIERSHRGERLVHATASGLGPTIGILIPLTPFAFEGALLSMVEAGAISVALGVGILSVFGAYMGSISGQRWYVSAARMGLAGLVVTGINLLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F0</accession>
    <name>R4W9F0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msrA</name>
        <name evidence="4" type="ORF">L593_07520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446343.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07520"/>
    <dbReference type="EnsemblBacteria" id="AGN01449">
        <property type="protein sequence ID" value="AGN01449"/>
        <property type="gene ID" value="L593_07520"/>
    </dbReference>
    <dbReference type="GeneID" id="16182145"/>
    <dbReference type="KEGG" id="sali:L593_07520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1540"/>
    <dbReference type="eggNOG" id="arCOG02816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_2"/>
    <dbReference type="OrthoDB" id="86136at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="3">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="20001" checksum="35E150910218318C" modified="2013-07-24" version="1">MTAQATFAGGCFWCIDAALEELDGVESTTSGYTGGHVEDPSYEEVCRETTGHAEAVRVEYDPDRVEYADLLEVFFSIHDPTTKDRQGPDVGSQYRSAVYYHDETQREIVEAFVADLEDAGVYDDPIVTEIEPVETFYVAEEYHQNYFEKNPDKPYCAAQVLPKVEKVRTEFDALTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H2</accession>
    <name>R4W9H2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447552.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13595"/>
    <dbReference type="EnsemblBacteria" id="AGN02658">
        <property type="protein sequence ID" value="AGN02658"/>
        <property type="gene ID" value="L593_13595"/>
    </dbReference>
    <dbReference type="GeneID" id="16180716"/>
    <dbReference type="KEGG" id="sali:L593_13595"/>
    <dbReference type="eggNOG" id="arCOG04652">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110996_1_0_2"/>
    <dbReference type="OrthoDB" id="108743at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="21318" checksum="88F6783540C88540" modified="2013-07-24" version="1">MAGSGDRGQAYTLESLIAALLLVTAVLFALQSVVITPTSAGALDRDVQGQLEQEANDVLVTAANEGELSRLARYWDCSTGTMASDMQSGAWVPNQGYANDVAPVEDLGESLNRTFGEGTRYNLLLVYDTGSGQNVTRVIYQGTPGDEVVSTSYTITLTESQQITAANAAGQSVAGCGDPVIERHPGSTGATWNVVEVRLVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M7</accession>
    <name>R4W9M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01644">
        <property type="protein sequence ID" value="AGN01644"/>
        <property type="gene ID" value="L593_08495"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08495"/>
    <dbReference type="HOGENOM" id="CLU_2534825_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="83" mass="9161" checksum="9FD335228C81925A" modified="2013-07-24" version="1">MTRLFGLAVVLFGFYTLFKLYTDLGVLAQRYVMSLGMVSFTFTEQTIEGTKIGVAVQLTAFALVCFFVGGMTLVESTRIKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S3</accession>
    <name>R4W9S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">L593_15070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_020447842.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15070"/>
    <dbReference type="EnsemblBacteria" id="AGN02948">
        <property type="protein sequence ID" value="AGN02948"/>
        <property type="gene ID" value="L593_15070"/>
    </dbReference>
    <dbReference type="GeneID" id="16180445"/>
    <dbReference type="KEGG" id="sali:L593_15070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3078"/>
    <dbReference type="eggNOG" id="arCOG04754">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_007764_2_1_2"/>
    <dbReference type="OrthoDB" id="3788at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
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    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
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    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="NAD_DNA_ligase_OB"/>
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    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HHH_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="601"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="629"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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            <name>NAD(+)</name>
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            <position position="191"/>
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        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <position position="425"/>
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        <ligand>
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        <location>
            <position position="444"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN02948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="682" mass="74803" checksum="B2D57BD0A550F80E" modified="2013-07-24" version="1">MADADNPYLEDPPTDFEPTDDLSEDRASEQAALLREAIREHDRRYYVEHDPVIADRTYDALFDRLVDLEEAFDLETADSPTNRVGGEPVDEFPTVEHVAPMLSIDQSGEESEVRAFDDRVRREVGEVTYVCEPKFDGVSLEVVYQDGHLQRVVTRGDGVEGDGVTNNARTVPSIPQRLSGDPPSDLTVRGELYMPRDDFQAYNRELVERGEEPFANPRNATAGTIRQQDPSVVAERPLAFVAFGVLDTSDPWPSRWAEHTALPELGLPVSDRVERHDSIDGVIAYRDELVATRDDLDFEVDGAVVKVNDREQQETLGTTSRHPRWAFAYKFPPRSEETTVRDVVLQVGRTGRATPVALMDPVDVGGVTVSRASLHNPEQIAELGVSIGDRVRVERAGDVIPQVVEVLDGANEDVHFKYPDECPACGTELERDGPIARCPAGLECPAQRRRSIQHYASRGALDIEGLGEETVDLLVDEGLVETPADLYELTVEDLADLEGFGERAATRLVDAIQDAREPDLSDFVTALGIPEVGGTTARTLARTFGSLDALRNATTDELEAVDDVGPIVAERIRDFFEADANQRVLDDLLEHVDPQAPDVEIGGGPFEGETIVFTGSLPSMTRQEATEQVERQGGNVTSSVSSNTDFLVVGENPGTTKRADADANDVAELDGEAFEERLTSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W5</accession>
    <name>R4W9W5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">NMD3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01914">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2027"/>
    <dbReference type="eggNOG" id="arCOG04149">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065087_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="399" mass="43025" checksum="609B92D0D562B3BB" modified="2013-07-24" version="1">MAGSPVGNLGAAIVDVPPRRRSHAFWAKPTSGLAMSNSGAFCPRCGDEIELPRERRAERGEPALCDACYFEDFELVDAPDRIQVTYCSECGAVKRGKHWEDVGAKDYTDVAIDAVTEELSVHVDADSISWAVEPEQIDQTTVRLTCHFSGVVRDTPVEATVVVPAKLSSGTCSRCGLIAGDFYAATVQVRASADREPSDTEIADARDIANEYVAEKEAGGDRDAFVSSIAEVEGGLDVKVSTTQLAREISNRIVQAHGGSVDSSERLITEDGDGNRVYRTAHVVRLPPVSIGDIVDPDDGEGPVIVTSARQTLSGTRLASGEDFEADFEDLPERAVLGDRTDVAETTLVAVEDEHAIQVLDPETYEATTIPRPDFVDTDAEEIPVFKHREGLHAVPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z2</accession>
    <name>R4W9Z2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_10520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446943.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10520"/>
    <dbReference type="EnsemblBacteria" id="AGN02049">
        <property type="protein sequence ID" value="AGN02049"/>
        <property type="gene ID" value="L593_10520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180139"/>
    <dbReference type="KEGG" id="sali:L593_10520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2169"/>
    <dbReference type="eggNOG" id="arCOG08943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045361_2_2_2"/>
    <dbReference type="OrthoDB" id="117161at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="13722" checksum="054788CFAF932F9D" modified="2013-07-24" version="1">MIALVVVSHSEQAALGIAEVAAEMGGDARIVPVGGDPDGGIGTTSPSIQDAIERAASGDDPSDESADGVVVLVDLGSAVMNAELAIDTLDADYPVQLADAPILEGALNAAVAAASPKATLEGVLARAEEARDYRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA05</accession>
    <name>R4WA05_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribonuclease FAU-1</fullName>
            <ecNumber evidence="6">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA-binding protein FAU-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fau-1</name>
        <name evidence="9" type="ORF">L593_10845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAU-1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447008.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10845"/>
    <dbReference type="EnsemblBacteria" id="AGN02114">
        <property type="protein sequence ID" value="AGN02114"/>
        <property type="gene ID" value="L593_10845"/>
    </dbReference>
    <dbReference type="GeneID" id="16180054"/>
    <dbReference type="KEGG" id="sali:L593_10845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2238"/>
    <dbReference type="eggNOG" id="arCOG04307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044303_0_0_2"/>
    <dbReference type="OrthoDB" id="83570at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01910">
        <property type="entry name" value="RNA_binding_AU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016730">
        <property type="entry name" value="RNA-bd_FAU-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018644">
        <property type="entry name" value="RNA-binding_FAU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DUF402" evidence="8">
        <location>
            <begin position="384"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="479" mass="51163" checksum="993C5D9DCAA39AEF" modified="2013-07-24" version="1">MSAVRIRGIYATALTRRLLDAGFEVVHASDPIDRRFDANFGTRPPSATIDTTTDRQGIEISGDPAAVAELGGTLAEVEVDTLTWPDPAPTGSVSNAVVSGTRGGGAVLDLPGGATGYLPFDDADGYVETGDRLRVQVRDPTPPWSDYDARLDSDVRVEDPGGLLRLVRGEDGVRANAPDADATALARTTELLDVAVPEGWGLRWRRAAADAGLDERGDALEAVIERAETIEDALADAPDPEAAAPRPIATPSATTWCWFGRESRLALDAHRRTVETTIPGHHRIKAADGSASAGVDLAESLVDEHTDGVDADELPFDAIARQFGPTDGDDLAIHHGKPDGRRLVLGTGDVTEYDPDGAVTVRREISSSGEYDALGTEREPGDVAITKLKEGRWWYPTIYRGADGERKGTYVNVCTPVELFPDAATYVDLHVDVVNPPAGEVRVVDDDELAEAVEEGHVSEDLAERARNVAERAQQALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA33</accession>
    <name>R4WA33_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">S-adenosylmethionine synthase</fullName>
            <shortName evidence="14">AdoMet synthase</shortName>
            <ecNumber evidence="6 14">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mat</name>
        <name evidence="16" type="ORF">L593_11555</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the AdoMet synthase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6 14"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447148.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11555"/>
    <dbReference type="EnsemblBacteria" id="AGN02254">
        <property type="protein sequence ID" value="AGN02254"/>
        <property type="gene ID" value="L593_11555"/>
    </dbReference>
    <dbReference type="GeneID" id="16180065"/>
    <dbReference type="KEGG" id="sali:L593_11555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2382"/>
    <dbReference type="eggNOG" id="arCOG01678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_2"/>
    <dbReference type="OrthoDB" id="21658at2157"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00136">
        <property type="entry name" value="S_AdoMet_synth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002795">
        <property type="entry name" value="S-AdoMet_synthetase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 16" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AGN02254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="43384" checksum="3B71021A345E6CDE" modified="2013-07-24" version="1">MTDRNIRVEAIDRDAVEDQEVEIVERKGIGHPDSICDGVAEHVSEALAQAYLDRVGTVLHFNTDETQLVAGEAAPAYGGGEVQSPIYMLIVGRATKEYQGTKIPTERIALEAAREYLSETIPELTLGSDIVVDVKLGEGSGDLQEVFGEDGASVPMANDTSFGVGHAPLTETERIVYEAEHRLNTEYADTNPELGPDVKIMGKREGDHIDVTVAAAIVDEYVGNLDEYDEAVRGVRSFVESVADEITDRSVDVYVNTADDYEEESVYLTVTGTSAEQGDDGSVGRGNRASGLITPNRSMSMEASSGKNPVNHIGKIYNLLSTEIAEDVVAEVGGIRDLRVRLLSQIGRPIDQPHVADVHVVTEEDVAVEDIEADVVDIVDEHLADVTSITERVIEGELSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA38</accession>
    <name>R4WA38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PyrE-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447173.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11680"/>
    <dbReference type="EnsemblBacteria" id="AGN02279">
        <property type="protein sequence ID" value="AGN02279"/>
        <property type="gene ID" value="L593_11680"/>
    </dbReference>
    <dbReference type="GeneID" id="16179817"/>
    <dbReference type="KEGG" id="sali:L593_11680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2407"/>
    <dbReference type="eggNOG" id="arCOG00028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111001_0_0_2"/>
    <dbReference type="OrthoDB" id="77963at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01214">
        <property type="entry name" value="PyrE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022854">
        <property type="entry name" value="PyrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF41">
        <property type="entry name" value="PTHR19278:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="74"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22113" checksum="4B79EF32A6B2DC8C" modified="2013-07-24" version="1">MKNVDDLIDSASELAEQGLSKGEIADELNVSRETASWLVERGGGNASTAPAVSSSAGDIHVDWSAFGRDSTRLEHLGAAMADMLQSEAENVDLTIGIEKAGVPLATSVARILDTDLGAYAPRKHQWDEGDIEDHGGTFSRNFAGIRGRECYVVDDTITSGTTMTETVEAIRSEGGEPVACMVLVDKRGVDEIEGVPVHSLLQVLSVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA74</accession>
    <name>R4WA74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447353.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12600"/>
    <dbReference type="EnsemblBacteria" id="AGN02459">
        <property type="protein sequence ID" value="AGN02459"/>
        <property type="gene ID" value="L593_12600"/>
    </dbReference>
    <dbReference type="GeneID" id="16180117"/>
    <dbReference type="KEGG" id="sali:L593_12600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2586"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035203_0_0_2"/>
    <dbReference type="OrthoDB" id="45411at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014651">
        <property type="entry name" value="UCP036983_2CBS_MJ1404"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036983">
        <property type="entry name" value="UCP_2CBS_MJ1404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="385" mass="42686" checksum="EEC42F70BA33D981" modified="2013-07-24" version="1">MDVSTIATEEYVAIDVNTRLGKARARFQEENSKGIIVTRDGEYAGVLGERELLQSHVEDDAKVGALIKPSRNDPAPKIDRYEDLRDTARQLVEGGTKVAPVFENGGFWGIVTADAILEAVLEHLDALTVGDIYTDEVVSIAEDDGIGTAINRLRENTISRLPVVNENGYLSGIVTTHDISEVAVRNMDVMGEGDRAGDIDRILDLPVYDVMANPVVTTTTDTDARVAVEQMLDHDIGGLVVTPADDDRLVQGILTKTDVLRALSYTEEQHMDVQITNIQLLDTISRQDVREAIEEVADKYQKMQVQHAHVRFHKHKEKLRGTPLIQCQIRLRTNKGQIAGSGEGYGARNAFHVALDKLERNVLERKGIQSDEEYRGQLLQKLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA95</accession>
    <name>R4WA95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1, 7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447458.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13125"/>
    <dbReference type="EnsemblBacteria" id="AGN02564">
        <property type="protein sequence ID" value="AGN02564"/>
        <property type="gene ID" value="L593_13125"/>
    </dbReference>
    <dbReference type="GeneID" id="16180404"/>
    <dbReference type="KEGG" id="sali:L593_13125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2690"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_2"/>
    <dbReference type="OrthoDB" id="72644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="244" mass="26596" checksum="0093059BF7854163" modified="2013-07-24" version="1">MHTVRFRDPAGAVREGTWTDDGVAFAGREYDLDEVDVLAPCDPEKIVCIGRNYVAHADERDEDVPDRPLLFLKPPNTVASHDDIVELPAGKETLEYEAELGVVIGEQCRDVAEAHAEDVIAGYTCGVDLSNRDDQSREQNWVRGKAFDGAAPLGPVLATPDEVPDDARIRLWQNGELRQDSTLDHLVFPIPELIAEISAYLTLEPGDVILTGTPEGVGPLADGDTIEIEVEGVGRLEHEVAIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB4</accession>
    <name>R4WAB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447553.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13600"/>
    <dbReference type="EnsemblBacteria" id="AGN02659">
        <property type="protein sequence ID" value="AGN02659"/>
        <property type="gene ID" value="L593_13600"/>
    </dbReference>
    <dbReference type="GeneID" id="16180719"/>
    <dbReference type="KEGG" id="sali:L593_13600"/>
    <dbReference type="eggNOG" id="arCOG07777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_910962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="31855" checksum="87EFDD4A71FF2EF9" modified="2013-07-24" version="1">MVTRDRGQLILVGAVAIALVLLGLVLVVNTALFTQVVGSEGTVETAKDGAISGQEVGEAIASSARSLNDDYGQTASSKNNTLDTNTIPNLEPILQNRSMESGGAFVSVNYDSINESGTFVSQNQSSGFTSVAGNPTWQPIPLGQEGDIGGFLMTIDYAASGTGDPFTVYVDSVGGPNRSLTITPESGSEVAISTSTGTTCSDVPVTSNTVRIDVTHGVVFEDHSCQFDLFAGTNPGYVMTFTGGDEVAGTYQFVTDSDLTSYPAYGAAGSQPTPTEAVWSFEYSFTYDTPGATVESESRVIDVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB8</accession>
    <name>R4WAB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13700"/>
    <dbReference type="EnsemblBacteria" id="AGN02679">
        <property type="protein sequence ID" value="AGN02679"/>
        <property type="gene ID" value="L593_13700"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2802"/>
    <dbReference type="eggNOG" id="arCOG08166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838386_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="34924" checksum="BB978B162794AADA" modified="2013-07-24" version="1">MVAVSDDGIVFGKLGEFVDPDGDLAEDNDHVLPHAGRVSPDLADVLSFAEQCAPETPVDDQSAYVADAVEVAGTRRATEVAQSSPAAEASFLTQVTEQELDGSTIRLASRLLEELQSPEPTYALGAGNPETGKTNTMSLLTELALLDHDEVVVLSNVRSWELTDVVVTSAHDLAVELLRHRGVPVVIFIDEASTHFDARTFQRAVAHQWSPLAKRFAKLGVVLCGLVGHTGKDVHPEAKAMVNLAFLKPEQTVAGFYSDWPRDSDVPVDPIFAGDVHQLEPTAVEYDPDDAAPWSWNLRPELFTEDLDWAGLLSALEKRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC5</accession>
    <name>R4WAC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447608.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02714">
        <property type="protein sequence ID" value="AGN02714"/>
        <property type="gene ID" value="L593_13875"/>
    </dbReference>
    <dbReference type="GeneID" id="16181005"/>
    <dbReference type="KEGG" id="sali:L593_13875"/>
    <dbReference type="HOGENOM" id="CLU_2839522_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="7332" checksum="6219C6129159BB04" modified="2013-07-24" version="1">MGALRDSSRFLFLLSLAGASYLLIAEGYSFDDRVVAVVTFGLGIFAVVLIAYRFREDFAYEDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG1</accession>
    <name>R4WAG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Growth inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447788.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14800"/>
    <dbReference type="EnsemblBacteria" id="AGN02894">
        <property type="protein sequence ID" value="AGN02894"/>
        <property type="gene ID" value="L593_14800"/>
    </dbReference>
    <dbReference type="GeneID" id="16181806"/>
    <dbReference type="KEGG" id="sali:L593_14800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3022"/>
    <dbReference type="eggNOG" id="arCOG03943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_2"/>
    <dbReference type="OrthoDB" id="100836at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12780" checksum="F6331BA745F2AF40" modified="2013-07-24" version="1">MDVNRGDVVLVAFGRSETGDSRPTRPCVVVQNDVGNEHASTTVVVPLTTAFGNERYPHEVLVRAGDAGLSEHAVALCSQPNTVDVKRDVVETLGRLPEDVLLDVDRALEYSLDLGGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS30</accession>
    <name>R4VS30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00350"/>
    <dbReference type="EnsemblBacteria" id="AGN00025">
        <property type="protein sequence ID" value="AGN00025"/>
        <property type="gene ID" value="L593_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.70"/>
    <dbReference type="eggNOG" id="arCOG03917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153002_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15704" checksum="7031F0DD786DAB91" modified="2013-07-24" version="1">MSIRSTCAIASTVEAGTENRCSERSAVDDRPFGRSFMCGCFQRYDVADESDETVQVWLVERTYSDDEQNLIILTYATTDGERYFRKERALTSFTDVRDTTAAVEASPANLGRVADPDERDRYAAEARLMADRHEPDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSF2</accession>
    <name>R4VSF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445034.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00925"/>
    <dbReference type="EnsemblBacteria" id="AGN00140">
        <property type="protein sequence ID" value="AGN00140"/>
        <property type="gene ID" value="L593_00925"/>
    </dbReference>
    <dbReference type="GeneID" id="16180744"/>
    <dbReference type="KEGG" id="sali:L593_00925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.190"/>
    <dbReference type="eggNOG" id="arCOG02254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167318_1_0_2"/>
    <dbReference type="OrthoDB" id="121332at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002753">
        <property type="entry name" value="UPF0058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036519">
        <property type="entry name" value="UPF0058_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42203">
        <property type="entry name" value="PTHR42203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01893">
        <property type="entry name" value="UPF0058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140371">
        <property type="entry name" value="SSF140371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="10672" checksum="E9A61F433DB460C1" modified="2013-07-24" version="1">MHKDELLELHEQMVTIMRHFRDREDSDPALFEPYEQLDIEPDHVHKSKNEHKHAVFVLGNALASAMSEDEFSSAGRIGKRMEELADDAEQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTB0</accession>
    <name>R4VTB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445344.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02495"/>
    <dbReference type="EnsemblBacteria" id="AGN00450">
        <property type="protein sequence ID" value="AGN00450"/>
        <property type="gene ID" value="L593_02495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180237"/>
    <dbReference type="KEGG" id="sali:L593_02495"/>
    <dbReference type="eggNOG" id="arCOG00845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907952_0_0_2"/>
    <dbReference type="OrthoDB" id="49774at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="317" mass="34072" checksum="4EF508424034D85F" modified="2013-07-24" version="1">MSDVTVRQARIDDHEAVAAFTRETWTDRELEDWIPDAFPEWIETDGDDQRTLVATVDGQVAGICQGVLLSPEEAWVQALRVHPDVRGHGVSRRMTDRLLAWCRDRGAVVARNMVFAWNGAGLGQSRASGFDPATELRFASPEPTAEAAPSDHGPRDAEAVVDPAAAWRYWTESDAREHLRGLAADDEESWALRELTRSDLDAAAEDDGAIAVRTSDRTVAMAVRSRIDTRPAETDAGAAGSEETVAVYGATAWDDLEACAALISAIAADAAGIGADDTKVVIPETVRHVSDVAACRVEIGDEPDFVLAADLSGRDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTF0</accession>
    <name>R4VTF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445389.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02720"/>
    <dbReference type="EnsemblBacteria" id="AGN00495">
        <property type="protein sequence ID" value="AGN00495"/>
        <property type="gene ID" value="L593_02720"/>
    </dbReference>
    <dbReference type="GeneID" id="16180365"/>
    <dbReference type="KEGG" id="sali:L593_02720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.551"/>
    <dbReference type="eggNOG" id="arCOG00037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381418_0_0_2"/>
    <dbReference type="OrthoDB" id="71195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="22009" checksum="3F2C6307E0FC9F4D" modified="2013-07-24" version="1">MTAGSLALCYSGGKDSTLAALLLEDFYDVTLVTAHFGVTDDWEHAAAAAERIGHEFERVEMERSVADDAVDQLREDGFPRNAIQSVHEHALETVAELDFDAVADGTRRDDRVPSVSRAHAQSLEDRHDVDYVAPLSGFGRGAVDRMVDATLEVTVGPSEEIRRADYEGELRALLAEAEGEAAIAEVFPDHDQTIVTDVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTU5</accession>
    <name>R4VTU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445544.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03495"/>
    <dbReference type="EnsemblBacteria" id="AGN00650">
        <property type="protein sequence ID" value="AGN00650"/>
        <property type="gene ID" value="L593_03495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180037"/>
    <dbReference type="KEGG" id="sali:L593_03495"/>
    <dbReference type="eggNOG" id="arCOG09065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117968_0_0_2"/>
    <dbReference type="OrthoDB" id="113451at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="206" mass="21112" checksum="57B993D96C0CD2EA" modified="2013-07-24" version="1">MTTTTNPGPLHRVLAGLQHRARVLLLVATRWRPLAVLVVGTLAYLLAFLYAMGDLEFEAAGWGITTVAEPWQRMLEPGPGPYTHEPIALVEFSAGQLLFSPLNTLLGLGLAVLVGTNLALSFLAITQPKSCGVGAGTGLAAAIPALLGGSACCAPTLLIVLGIQAGSLLVGLLAWLLPIGATLLVVTLVYVAGRVDSAALRGASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUB8</accession>
    <name>R4VUB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445689.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04220"/>
    <dbReference type="EnsemblBacteria" id="AGN00795">
        <property type="protein sequence ID" value="AGN00795"/>
        <property type="gene ID" value="L593_04220"/>
    </dbReference>
    <dbReference type="GeneID" id="16180870"/>
    <dbReference type="KEGG" id="sali:L593_04220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.858"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OrthoDB" id="995at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="60"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="312"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="924" mass="103252" checksum="C35CC19C53F44C60" modified="2013-07-24" version="1">MDWREGFAAATGFDPEEHRISDADVLDRLDPAIREWWIQEFGEYVPENGGFFTPPQEEAIPHVLDGKNALVCAPTGSGKTLASFSAVIDDLVRKGRADDLDNEVYCLYVSPLKSLANDIHRNLTEPLEGIQSVMASQGDDDPVEIRHAIRHGDTDDAERQAMLETTPHILNTTPETLAILLNSPKFKEKLRSVEYVIVDEIHALADGKRGTHLSVSLERLEHLANASPTRIGCSATIEPLEDVGEFLVGQQEPGGVLASGGSEGSGDERSESAGDHRDVEIVDTRFAREFDLALECPTEDLINTPRDAVTGRFYDRLHELVQANTNTIVFTNTRSGAERVLHTLRERYDEYDEETSGCHHGSLSRERREDIEQGLKDGDLDVVTSSTSLALGIDMPHVDMVVQVGSPKSVAELLQRVGRAGHRVGQTVTGRVIALDRDELIECAVMLKKAEEGFVDAVSIPEGAQDVAAQHVYGMAINGPRPESEVVGILRRAYPYRDYDDAQWEQLVRYLRAEYDNLEEKNVYAKIWRDENDPPSGRHHYEDYDVGQQLIGKRGRLARVIYMTNIGTIPDSFTCQVVTRSGDEWVGQLDEGYLDTLEPGDVFVLGGDRFAYRYRRGSKVYVDRTSARPTVPSWYSERLPLSFDLGKEILAFQQELVEVLANRGPAAARTWLRQFPLDDNTVRALVRFFETQLEFAGTESVSTPDRLVVEVERDHDEYKRHYHVRSAYGRRFNDGMSRLLAYRCARETGANVSVAVADTGFTLSMPLNRKIDLAGILEDLDPADVRADLRSALDGTDLLQRYFRINATRSLLILKRYKGYEKSASEQQVSSEMLLSFAESLEDFAVIEETYREILEDRLHVAGIEWACQRVQAGDLAVEQFTVDTPSPAAFGLATLAASDVVLAEDESAVLQEFHQRVIDAIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUX5</accession>
    <name>R4VUX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN00071">
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        <property type="gene ID" value="L593_00580"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG13467">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="103" mass="11473" checksum="CA74B4F97334C37E" modified="2013-07-24" version="1">MSSNPTESRSADDWSVEAIKRMFDPEELRRRNLVSLGMDLLILVTVGFLAILFTKGFLASMLAVIPVATLLYFGWASSKAFFVSELLAIAIALLATYTYMLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV31</accession>
    <name>R4VV31_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00131">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG06206">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2713011_0_0_2"/>
    <dbReference type="OrthoDB" id="127344at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="7634" checksum="08BF0C2ACDBE7B8F" modified="2013-07-24" version="1">MVYTLQYYDLVLIAVITPVLIGVGLGSFTPLGMPIAIVGLGAVSIAVMYYGLFVNGPVDEVQDLTDEVEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV33</accession>
    <name>R4VV33_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16606" checksum="5A25A9F166C20262" modified="2013-07-24" version="1">MTYENLDAKLVNELLGDGRASLRSLAEELDVSVTTVSNHLGDLEEDGVVRGYTPIIDYSKMGFDVTAILQLKVEGDALPEITDRLDAEKQMVSVYEVTGNYDIIAIGKFADTDDMNAQIKTLLTDPDIKESNTSVVLNAASENEQFELETE</sequence>
</entry>
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    <accession>R4VVB4</accession>
    <name>R4VVB4_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="L593_06105"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06105"/>
    <dbReference type="HOGENOM" id="CLU_1700345_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17885" checksum="316B5AE260C248FE" modified="2013-07-24" version="1">MVPDWPALNRRFESGRLKQSQDEILKPFPGWVVADPDLDEEHLLAPARSPTFDDLLHLIREQYEESDNVSTEIAWDSFDTISPEKYEFHENDLRKALHLTGEGVDNDVYFELEAVQYFIRERIQKLDSRFRRSGVFLILLGFSIQALGTAFISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW89</accession>
    <name>R4VW89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maltose O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07725"/>
    <dbReference type="EnsemblBacteria" id="AGN01490">
        <property type="protein sequence ID" value="AGN01490"/>
        <property type="gene ID" value="L593_07725"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1583"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="3">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="22181" checksum="FB793F65EC1C1FB6" modified="2013-07-24" version="1">MTASRARIRLERYANAMSEKEKMIAGELYDPTDPELREDHERAQELTRAFNDTEPDQHDRREALLRDLLGTVGDSVYVTPPFRCDYGYNIHVGDRFYANFDCVFLDVCPIEIGEECMLGPSVHVYTATHPLDAEERTSGVEYGKPVEIGDQVWIGGQAVINPGVTIGDRAVIASGAVVTEDVPADVVVQGNPAEVVREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWB4</accession>
    <name>R4VWB4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase L593_03075</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445460.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03075"/>
    <dbReference type="EnsemblBacteria" id="AGN00566">
        <property type="protein sequence ID" value="AGN00566"/>
        <property type="gene ID" value="L593_03075"/>
    </dbReference>
    <dbReference type="GeneID" id="16180431"/>
    <dbReference type="KEGG" id="sali:L593_03075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.622"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_0_2"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="240" mass="26049" checksum="44BFCEC9DB3FB1B7" modified="2013-07-24" version="1">MELTWHGHSTWHVTVGDTSILIDPFFDNPHTDLSPDDLDAPDYLLLTHGHADHIAHAAEFADSAVVCGTPEITGYLDDEHETQETIGMNIGGTVEAGDAFVTMVQAMHTNGIETGYGMDAGIPAGYVISDTKPTQLADEESETFYHAGDTALMTEMRDVFGPYLQPDAAAVPCGDHFTMGPQQAAIAIDWLDVDHAFPMHYDTFPPIEIEVQDFVNEVRGTGSDAEVHVLDGDETFTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX95</accession>
    <name>R4VX95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446749.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01855">
        <property type="protein sequence ID" value="AGN01855"/>
        <property type="gene ID" value="L593_09550"/>
    </dbReference>
    <dbReference type="GeneID" id="16182688"/>
    <dbReference type="KEGG" id="sali:L593_09550"/>
    <dbReference type="eggNOG" id="arCOG08211">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074083_0_0_2"/>
    <dbReference type="OrthoDB" id="74858at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046157">
        <property type="entry name" value="DUF6159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19656">
        <property type="entry name" value="DUF6159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="28937" checksum="AA29305FC133F84F" modified="2013-07-24" version="1">MGFFGRLKTGWNLAKDSTHVLREEPSLAVFPLLSGIFGLLFMAALFGGTYVTAGLEEGPVTYAVLFVLYFGSTFIAAFFNAALVHNAREVFHGRDPTLGEGMRAAWSHKRTLAIWALVAATVGMILRAIEGSDNPLAEIAAMLFSVAWGILTYFIVPVIVFEDVTPTEMFKRSGETFKSTWGETAGAGFGVGLVTAIFAIVGLALAVGVFFLFGAGTFGVVGGVAVGAVVLLAAYLFGSALGYIARTALYVYATENEQPEAFRNVDFSRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXB6</accession>
    <name>R4VXB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_04785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445800.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04785"/>
    <dbReference type="EnsemblBacteria" id="AGN00906">
        <property type="protein sequence ID" value="AGN00906"/>
        <property type="gene ID" value="L593_04785"/>
    </dbReference>
    <dbReference type="GeneID" id="16181089"/>
    <dbReference type="KEGG" id="sali:L593_04785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.978"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OrthoDB" id="8547at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="7"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="11">
        <location>
            <begin position="483"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="612" mass="67049" checksum="1B88205B4EE8A425" modified="2013-07-24" version="1">MTVHEHDVIVVGAGGAGLRAAIAAHEEGADVAMVSKLHPVRSHTGAAEGGINAALREGDDWELHAYDTMKGSDYLGDAPAVETLAQDAPQEVIDLEHWGMPFSREEDGTVSQRPFGGLSFARTTYAGAETGHHMLHTMYEQVVKRGIPVYDEWYVTRLAVTDEPDPADRTCTGVVGYEIRTGEVAGFRARNGVVLATGGPGQAFDHTTNAVSCTGDGQAMAYRAGVPLEDMEFVQFHPTTLPSTGVLISEGVRGEGGILYNSEGERFMFEYGYANNEGELASRDVVSRAELTEVNEGRGVEDEYVYLDMRHLGEERISDRLENIVHLAEDFEGVNAYEEPMPVKPGQHYEMGGIETNENGATVVDGLYAAGECACASVHGANRLGGNALPELLVFGARAGRHAANPERADAKLETGRTDEAEPEEDLGAPVEPGAVDAPSEDVSADGGAVESEDVLVDAIHQERERIDGLLERDDGVNHAEIRAEVQQTMTENVNVFREKESIKQALRDIRDARKRYQDVAVSDPSRTYNTDLIHTIETRNIIDAAETIALGALARDEFRGAHWRAEHQERKDDEWLKHTLVSWDDGRPDLWYKPVDLQGQNKVYEPKERSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXD8</accession>
    <name>R4VXD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445820.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04885"/>
    <dbReference type="EnsemblBacteria" id="AGN00926">
        <property type="protein sequence ID" value="AGN00926"/>
        <property type="gene ID" value="L593_04885"/>
    </dbReference>
    <dbReference type="GeneID" id="16181134"/>
    <dbReference type="KEGG" id="sali:L593_04885"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="OrthoDB" id="25689at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41857" checksum="B114D74929B7E7E1" modified="2013-07-24" version="1">MRDVVLVTADSVRYDFAEEMAFVDSLDPMLGITAGHYTRPSLGGLHSARLTGSIQSKAVSPTIAEVFDDAGYTCLGVAASAQADPAFDFDAGFDHYENFMDGGGNAVENRRSSLREYLGQFEVVRAVYHRLFPMEAVLSGLPPDDDVVDHAIEHFNDAEGPRFLWVHLMESHRPYGRGDDALPTELDRKAEASGRDSLLPDPELTDAEHEELVDTYRDALAQTDERVERLYEEIDAEDPIFAFTSDHGDELGEEGYYYHQGYRRRVPDPIVQVPLAIDGVDVAADRASLLDVGPTLASAAGVEPPAEWPGHDLRESGTEKAVTVAPWHEDATVAIRDRESTLIAADADVSFEEGGEEASVGRADVDESVEQRLQELGYKDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXV9</accession>
    <name>R4VXV9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ORF">L593_10825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10825"/>
    <dbReference type="EnsemblBacteria" id="AGN02110">
        <property type="protein sequence ID" value="AGN02110"/>
        <property type="gene ID" value="L593_10825"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2234"/>
    <dbReference type="eggNOG" id="arCOG04772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049847_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="445" mass="46017" checksum="E84EB12B26F90C58" modified="2013-07-24" version="1">MLPDRLLTDMSDDEGPDSGTEADAPAGADPDDAEDAATEQSDGSEAAADAESTEAAGADASPDATANGDAGSNAAEAAAVESEAPAIGEDLTQRIAQYDESLASEVSLVVEKAIELKNRVDEQAEEIEEQAERIDDLESALARSKADFQNYKKRQDREKDRIRERATEDLVERLLDVRDNLTRALEDDHDDVDSLKEGVEMTLREFDHVLDDENVSEISPDLGDDVDPQRHEVMMRVDSDQPEDSIADVYSSGYEMADKVLKTAQVTVSDGPADDATDDDEETEAGAEGEDGADDGDADAAGDGDAAGEGGATDDGAAADDADAPDDDADAVDEAKDAVDEADDDVNEGGAADEADSSDEADDGATAAEPAPAAEPVEPASEDAIAAEPVSEEADAPADDGDGDRDGDDTDGSGDGASSENSADGDADESADSKASDADASESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY38</accession>
    <name>R4VY38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446065.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06110"/>
    <dbReference type="EnsemblBacteria" id="AGN01171">
        <property type="protein sequence ID" value="AGN01171"/>
        <property type="gene ID" value="L593_06110"/>
    </dbReference>
    <dbReference type="GeneID" id="16181717"/>
    <dbReference type="KEGG" id="sali:L593_06110"/>
    <dbReference type="HOGENOM" id="CLU_1202662_0_0_2"/>
    <dbReference type="OrthoDB" id="102832at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="230" mass="26463" checksum="E86F8E6E844E1677" modified="2013-07-24" version="1">MSETSDQSLFEQELETVHQQYLRRDLEDRLEKVATEMEETMLQAIIARDFLDLEVKVVDEAKEKVQEAGGYADERDFDALDDIIDNVEDQVSQEAHQIENKIHEERTEERDRVRAMRKLNEHVEAADMGKLNALESLLDDWNWKAQVYTDEAEESFEAKQQEARDVAATMSNALQQVQKDLLGSYSGTTLEDVMDQLLSDEPPCFNDLSEEEREALTGSNLANYLEIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYC7</accession>
    <name>R4VYC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447154.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11585"/>
    <dbReference type="EnsemblBacteria" id="AGN02260">
        <property type="protein sequence ID" value="AGN02260"/>
        <property type="gene ID" value="L593_11585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180208"/>
    <dbReference type="KEGG" id="sali:L593_11585"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165372_0_0_2"/>
    <dbReference type="OrthoDB" id="60115at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="110" mass="12063" checksum="578CB3C39ADC809D" modified="2013-07-24" version="1">MSRTSPTKSESSNAVQDLDRFYRALADGRRRTAIDVLKQRTSLDLDALANEIVDRESDVADPTSVKITLVHQHLPLLAEAGIVHYDEDAGDVMLRQSIVDLLPPAGLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYE5</accession>
    <name>R4VYE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447174.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11685"/>
    <dbReference type="EnsemblBacteria" id="AGN02280">
        <property type="protein sequence ID" value="AGN02280"/>
        <property type="gene ID" value="L593_11685"/>
    </dbReference>
    <dbReference type="GeneID" id="16180213"/>
    <dbReference type="KEGG" id="sali:L593_11685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2408"/>
    <dbReference type="eggNOG" id="arCOG04587">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264542_0_0_2"/>
    <dbReference type="OrthoDB" id="83850at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="22012" checksum="F770C2CD1500E69A" modified="2013-07-24" version="1">MSSEPTASVYRLHSTLELPLEDVHDLVDEANFPEGVADVDVTRRNNTLILSATAEDTSISKYTPTAQLKASVVENRVYEEDPEEVRRRQGGPSWGEEEEEEIESELVEYAAFKGDRETVLQNTQLQYEMFQVLREIALISEKGTLTAITCEDGELDSWRIVEGDERPSSIEVVEGPADEDAAQSGVNWRDNKFISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYH3</accession>
    <name>R4VYH3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01276">
        <property type="protein sequence ID" value="AGN01276"/>
        <property type="gene ID" value="L593_06645"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06645"/>
    <dbReference type="eggNOG" id="arCOG01207">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163109_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="13836" checksum="DC9BDD4DF6B2E6E6" modified="2013-07-24" version="1">MENEESQHYTDNAALTRLFGDSPRTKILAVLLQQGRDTNVSTIADVGGMSRSSVYRHLDDLIELGVVEKTREIGGSPLYQIDKENRVSKELAELEWALVDEIAEETDEGVDDDFEIPESPPDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYQ1</accession>
    <name>R4VYQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446260.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07095"/>
    <dbReference type="EnsemblBacteria" id="AGN01366">
        <property type="protein sequence ID" value="AGN01366"/>
        <property type="gene ID" value="L593_07095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182006"/>
    <dbReference type="KEGG" id="sali:L593_07095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1450"/>
    <dbReference type="eggNOG" id="arCOG03458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1207596_0_0_2"/>
    <dbReference type="OrthoDB" id="80417at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="26495" checksum="FD7A27375749DA0C" modified="2013-07-24" version="1">MAGFVEIVVIAALAQLTVLPGEKVQFIIAGLSTRYHPLVVVGAAGSAFAGWTALEIAFGEAIQRALPPIVLDGFTVALFLLFAVMLVRSAPEPDADWGAATASDGPASDDAAGSAVGAKTDGGIGATRRIAPDVAGEFSIFGYSVGGRIGSFGSIFALMAAGEFGDKTQLVTISLAATYGATPAIWLGEMLVIVPVSLVNAYAFHKFAHRINLRLAHFVGAGIFAFFAADTVLAMTTGFSVWETVVEWLSAVVLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYZ7</accession>
    <name>R4VYZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07630"/>
    <dbReference type="EnsemblBacteria" id="AGN01471">
        <property type="protein sequence ID" value="AGN01471"/>
        <property type="gene ID" value="L593_07630"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07630"/>
    <dbReference type="HOGENOM" id="CLU_2857256_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6875" checksum="90CF3CA47CC9C360" modified="2013-07-24" version="1">MAVSAWSWFGQRRSADAEASGDLANERPTASATDRHRGRTITADCSIDVGHGPTSWLTHCAAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYZ8</accession>
    <name>R4VYZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="4">DERA</shortName>
            <ecNumber evidence="4">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="4">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="5" type="ORF">L593_12755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447384.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12755"/>
    <dbReference type="EnsemblBacteria" id="AGN02490">
        <property type="protein sequence ID" value="AGN02490"/>
        <property type="gene ID" value="L593_12755"/>
    </dbReference>
    <dbReference type="GeneID" id="16180155"/>
    <dbReference type="KEGG" id="sali:L593_12755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2617"/>
    <dbReference type="eggNOG" id="arCOG04320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_2"/>
    <dbReference type="OrthoDB" id="74992at2157"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="24178" checksum="0D0C60875064D6C7" modified="2013-07-24" version="1">MLSATALQENPERVASLVDHTNVDPAATRADIRQLCEEVLEYGFCSAVVVPYHAELAHEMVGDEANVAAVVGFPYGIQNSEAKRAECRAIAEFVDEFDMVMNRTAFANGDANAVVEDVEAVRDAVGDATLKCIVESPALSAEETTEAAELVEAGGADYVKTAVGYDGPTDPAEVEAIRRGVDPETGVKASGGISSFEEVLEMVEAGATRIGASSGVEIVESSREYRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ44</accession>
    <name>R4VZ44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446415.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07880"/>
    <dbReference type="EnsemblBacteria" id="AGN01521">
        <property type="protein sequence ID" value="AGN01521"/>
        <property type="gene ID" value="L593_07880"/>
    </dbReference>
    <dbReference type="GeneID" id="16182246"/>
    <dbReference type="KEGG" id="sali:L593_07880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1614"/>
    <dbReference type="eggNOG" id="arCOG01588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195720_0_0_2"/>
    <dbReference type="OrthoDB" id="123863at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="5808" checksum="899630E855C51999" modified="2013-07-24" version="1">MTECVECGAEVSLHENLEVGEIVDCTTCGAELEVVGVDPVELETAPELEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ69</accession>
    <name>R4VZ69_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">GMP synthase [glutamine-hydrolyzing] subunit B</fullName>
            <ecNumber evidence="5 12">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">GMP synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">guaAB</name>
        <name evidence="15" type="ORF">L593_08005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="5 12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446440.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08005"/>
    <dbReference type="EnsemblBacteria" id="AGN01546">
        <property type="protein sequence ID" value="AGN01546"/>
        <property type="gene ID" value="L593_08005"/>
    </dbReference>
    <dbReference type="GeneID" id="16182286"/>
    <dbReference type="KEGG" id="sali:L593_08005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1640"/>
    <dbReference type="eggNOG" id="arCOG00085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_0_2"/>
    <dbReference type="OrthoDB" id="31932at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00345">
        <property type="entry name" value="GMP_synthase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026598">
        <property type="entry name" value="GMP_synthase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN01546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="33984" checksum="A4FC564A6E18D1AE" modified="2013-07-24" version="1">MVNADEFIDEKIAEIDEEIGDANAVIALSGGVDSSTAAALAYEAVGDQLTPVYVDTGLMRKGETEQIRETFAYMDSLRIVDARERFLEELAGVTDPEEKRHIIGEQFIREFETVAKDVDADYLVQGTIYPDRIESEGTIKSHHNVGGLPEVVDFEGIVEPMRDLYKDEVREVARALDLEEVVSERMPFPGPGLAVRIIGPVTEEKLEVAREANHVVEEELEEYEPWQALAAVIGKATGVKGDNRVHGWVVSVRSVESRDGMTARAQEIDWDTLQRIQSRITGENANVSRVVYDVTHKPPATIEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZI0</accession>
    <name>R4VZI0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13680"/>
    <dbReference type="EnsemblBacteria" id="AGN02675">
        <property type="protein sequence ID" value="AGN02675"/>
        <property type="gene ID" value="L593_13680"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13680"/>
    <dbReference type="HOGENOM" id="CLU_1656956_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="159" mass="15893" checksum="DC79913696F73E5E" modified="2013-07-24" version="1">MVFAGAGVAILLVAVAAGGGAAAPAEEPLVNGSVNITDAPNQSVYVDVEFAADANLDAYLFDPAGNETANASISSTTGSIGSHSFVASQNGTYRVEVYGNASDVSAIWVGNESDTSENATFVGGATADDGSSSNLWIVAAGLAFTLMLAAVGVVARSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW7</accession>
    <name>R4VZW7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine 54/55 synthase</fullName>
            <shortName evidence="4">Psi54/55 synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pus10</name>
        <name evidence="6" type="ORF">L593_14305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447694.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14305"/>
    <dbReference type="EnsemblBacteria" id="AGN02800">
        <property type="protein sequence ID" value="AGN02800"/>
        <property type="gene ID" value="L593_14305"/>
    </dbReference>
    <dbReference type="GeneID" id="16181181"/>
    <dbReference type="KEGG" id="sali:L593_14305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2928"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OrthoDB" id="61936at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01893">
        <property type="entry name" value="Pus10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005912">
        <property type="entry name" value="Pus10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="THUMP" evidence="5">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="459" mass="50394" checksum="C2ACD5E5C71FB7A1" modified="2013-07-24" version="1">MDVVAAARRLLESGPVCDSCLGRPFADRSFGLTNEQRGRSLRTAVALADDADFESGPTADCWVCEGHCAEHDAWAERVVDAAADYDFDTYQVGTRTPPLIEENDRLLREEAGLDPDAGEAFKSAFNREVGKRFGREAGAEVDFDRPDVLALLNLERGDVDVQVNPAFVYGRYRKLERDVPQTEWPCRECGGSGKQLGEDGEEDCEYCDGTGYMYPTSVEQEIAPLVRDAMEGEEALFHGAGREDVDALMLGTGRPFVVEVKRPHRRSPDVEALEAEINDAAAGRVEVEGLRLATYEMVERVKELDASKRYRAYVATEAPLDDASFADALAELDGETVEQYTPERVDHRRASTTRTRTVYEIDGELHDSAGSDGGAVAPDAVIASRYEDELDLDAIERTGTVEIHGEGGLYVKELISGDEGRTEPSLAGLLDVPITVTALDVLAVEGEEESFEDEAYFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZX7</accession>
    <name>R4VZX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein uspa-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446670.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09155"/>
    <dbReference type="EnsemblBacteria" id="AGN01776">
        <property type="protein sequence ID" value="AGN01776"/>
        <property type="gene ID" value="L593_09155"/>
    </dbReference>
    <dbReference type="GeneID" id="16182637"/>
    <dbReference type="KEGG" id="sali:L593_09155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1878"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="15654" checksum="A07FF0E1FC228C34" modified="2013-07-24" version="1">MYQRILLPTDGSESAHAALDHALDIARQYDAELHVLHVVSAAYAEGGPGHATAVEALEEHGEETFERIRERTEALDVETACEQRHGEPHAVIVEYADDADCDLTVMGTHGRTGLQRYLLGSVTEKVVRTSDVPVLTVRHGGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W020</accession>
    <name>R4W020_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447749.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14595"/>
    <dbReference type="EnsemblBacteria" id="AGN02855">
        <property type="protein sequence ID" value="AGN02855"/>
        <property type="gene ID" value="L593_14595"/>
    </dbReference>
    <dbReference type="GeneID" id="16181343"/>
    <dbReference type="KEGG" id="sali:L593_14595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2980"/>
    <dbReference type="eggNOG" id="arCOG01035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_2_1_2"/>
    <dbReference type="OrthoDB" id="45246at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="34730" checksum="7DF5B689BB83655E" modified="2013-07-24" version="1">MQPVFLASDDLRGLAEPVAFVDAVRSGYRQRGNGAPAKPRTTLGSSDPPGMLTGYTAILPETGAMGGYTYSAGFEAGDAWFVTPLFDAESGEPLAILDGAWMNPFKTGAAGAVAVDALARHDANTVAVIGSGPQARGQLRAIATVRDLSEVRVYSPTTAHRESFASEFDERLEAAVRAVPDSASAIDGADVVVTATNASEPVFDGEQLDPGTHVTAMGQYHPEKRELDHPTIQRSRYVPDLRDRVEQDAGSFLDALEAGVVDESHVHAELGDVVAGTAPGRTSDEQITVFDSGGTGIETVAAAHLLYERAIERGLGTELELSAASEALTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W079</accession>
    <name>R4W079_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">o-succinylbenzoate synthase</fullName>
            <shortName evidence="4">OSB synthase</shortName>
            <shortName evidence="4">OSBS</shortName>
            <ecNumber evidence="4">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menC</name>
        <name evidence="7" type="ORF">L593_14930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447814.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14930"/>
    <dbReference type="EnsemblBacteria" id="AGN02920">
        <property type="protein sequence ID" value="AGN02920"/>
        <property type="gene ID" value="L593_14930"/>
    </dbReference>
    <dbReference type="GeneID" id="16181586"/>
    <dbReference type="KEGG" id="sali:L593_14930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3050"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_2_2"/>
    <dbReference type="OrthoDB" id="66204at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="36347" checksum="F90272CF4AFCCF14" modified="2013-07-24" version="1">MDLDLQPFELDLVEPLRTADRTIESRRGFLVRVRTEDRRGLGEATPLPGWTESYDACEDALERAADRLSVRGPDATLDELADAPAARHGLSLAIADLRARRIDVPLLRELGGGSRSRHLRVNATIGDASVSDTVEAAEHAVADGFDCLKLKVGARSLDEDAERLEAVRSAVGADVTLRADANEAWDRATAEAAFERFADASVSYVEQPLNADDLIGHAKLRGGSVDVALDETLAVANHDRVLDVDAADVIVCKPMVLGGPDRTIGLARRGRRAGVRPVVSTTIDGVVARLGALHVAGALAPIDACGLATGDRLANDLGPDPAPVEDGTMTIPRGAGTGLRLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0E2</accession>
    <name>R4W0E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad24a/uvrB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10105"/>
    <dbReference type="EnsemblBacteria" id="AGN01966">
        <property type="protein sequence ID" value="AGN01966"/>
        <property type="gene ID" value="L593_10105"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2083"/>
    <dbReference type="eggNOG" id="arCOG00554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010611_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="226"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="693" mass="76473" checksum="D6587A452763A9A7" modified="2013-07-24" version="1">MRVGTLFCHGSGDEFLVAPYRDGDRLFRAKLELKATDAGPRPGRFRVLNGAQEDLRDPMEFVDIARRADRIRISEQTSPRDRERIRECLEGYQLEATTVRTCRHCSQAGLYSPITEETAISHGDDTICRSCAKQELERELRHQGSMTGAARQRLEELLWKVKDLDRITDLLKGRLDPDLTKVDEMDATVQAVDPVPVADLDVHPDLQAYLDGKYDELLPVQSRAVHAGLLDGEDQLVVSATATGKTLVGELAGIDRVLRGEGKLLFLVPLVALANQTYEDFQEAYGDLVDVTLRVGGSRVRDSGQAFDPNADVIVGTYEGIDHSLRVGKDLGDVGTVVIDEVHTIAEEGRGHRLDGLISRLKYYCEERAANRTTGSGGASADSPEAADPSAGTQWIYLSATVGNPGELAAGLDASLVEFEERPVPIERHLTFADGREKPDVANTLVKREYDHESSKGYHGQTIIFTNSRRRCHEIARKLDYSAAAYHAGLDYGERKSVERRFLNQDLAAVVTTAALAAGVDFPASQVVFDSLAMGIEWLTVQEFEQMLGRAGRPDYHDRGRVYVLVEPDCAYHNSQERTEDEVAFQLLKGEMEPVRTRYDGAAGVEETLANVVVGGAAAKRLNDRMVGQIPTTHALGKCLEYEFIDGLEPTDLGRAVTSHFLAPDDAFRILEGIRHDEDPYEIVARVILADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Q2</accession>
    <name>R4W0Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447025.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN02131">
        <property type="protein sequence ID" value="AGN02131"/>
        <property type="gene ID" value="L593_10930"/>
    </dbReference>
    <dbReference type="GeneID" id="16181682"/>
    <dbReference type="KEGG" id="sali:L593_10930"/>
    <dbReference type="eggNOG" id="arCOG02920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="12782" checksum="B7F9768B328E315F" modified="2013-07-24" version="1">MLATTGVAAVSALAGCGGGGGTEENGDGGGGGESGDATVTVGAEGESHFSPQSVEIAVGETVVWESVSPDHQIRPQETPEGADWSGMGASFLGEGQTYSHTFETAGTYTYSCSTYHSSAEPGTVEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Q6</accession>
    <name>R4W0Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10955"/>
    <dbReference type="EnsemblBacteria" id="AGN02136">
        <property type="protein sequence ID" value="AGN02136"/>
        <property type="gene ID" value="L593_10955"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10955"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="127"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="38247" checksum="D137C40485A1207C" modified="2013-07-24" version="1">MTSETVALATPFVVGALVLSFTLVEVRSLFRLLDGRRYRQYWAAAGILIALFFVGYLLAAGLLLVGSQSLLVSITGAFALLGAVFAFLVVTVGERTIDDLVRSRDELERREEEFERLYEVTDVLNRILRHNLRNNMNVILGRSDMLHDDSTESEHVDAIQAEAQKLVEIGEKARAIHDTLDAEVSADVRPVETFVSPVVADVREEYPNATVTVDAEEDLWVEAGALVETAVENVLDNAIRHNEGAASVTISIVATADDFVAVSVADDGPGIDPYEIQAIREQRETPLQHGSGLGLWLSSWIVDQYDGGISFEDNDPTGSVVTLTLPRAQPPSPDGVEARQDDQADAQSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W127</accession>
    <name>R4W127_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylyl cyclase CyaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447150.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11565"/>
    <dbReference type="EnsemblBacteria" id="AGN02256">
        <property type="protein sequence ID" value="AGN02256"/>
        <property type="gene ID" value="L593_11565"/>
    </dbReference>
    <dbReference type="GeneID" id="16182777"/>
    <dbReference type="KEGG" id="sali:L593_11565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2384"/>
    <dbReference type="eggNOG" id="arCOG01723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_2_0_2"/>
    <dbReference type="OrthoDB" id="123503at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="21626" checksum="8E9B9EB4C83EAB67" modified="2013-07-24" version="1">MYEVEVKVAAEHDVVRERLPDDAEALGTVEQVDTYFDAPHRDFAETDEALRLRRERRLHSGSAADEGQPDGDGGWTTELTYKGPLLEAESKSREELETEVLDGEAMEGALDRLGFEPAATVEKQRERYAVGEFIVSLDAVAGLGEFVEVETEIEATDGVDAIDGPRKEALAVLERLGCDPGEQIRTSYLGLLLADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W151</accession>
    <name>R4W151_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM-barrel signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447180.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11715"/>
    <dbReference type="EnsemblBacteria" id="AGN02286">
        <property type="protein sequence ID" value="AGN02286"/>
        <property type="gene ID" value="L593_11715"/>
    </dbReference>
    <dbReference type="GeneID" id="16179921"/>
    <dbReference type="KEGG" id="sali:L593_11715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2411"/>
    <dbReference type="eggNOG" id="arCOG10160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058589_0_0_2"/>
    <dbReference type="OrthoDB" id="47161at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP_hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="278" mass="30071" checksum="355D23F4A7F613A0" modified="2013-07-24" version="1">MQFTRDESLERLTETVANEEPIIGAGAGTGMSAKFAERGGVDLLIIYNSGRYRMNGRGSLAGLLPYGDANEIVVDMGRQVLPVVEDTPVLAGVNGTDPFRQMDVFLEELDRRGFSGVQNFPTVGLIDEDSQFRQNLEETGMGYDKEVEMIQAASDRGMLTCPYVFSEEQARSMAAAGADVIVSHMGLTTSGDIGAETALDLDDAAERVQAHHDAATAENDDVLVICHGGPIAWPDDAQYVLEHTDGVFGFFGASSLERLPTEQAIEEQARAFKEIDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1G4</accession>
    <name>R4W1G4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">L593_12535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447340.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12535"/>
    <dbReference type="EnsemblBacteria" id="AGN02446">
        <property type="protein sequence ID" value="AGN02446"/>
        <property type="gene ID" value="L593_12535"/>
    </dbReference>
    <dbReference type="GeneID" id="16180015"/>
    <dbReference type="KEGG" id="sali:L593_12535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2573"/>
    <dbReference type="eggNOG" id="arCOG04134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_2"/>
    <dbReference type="OrthoDB" id="80060at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="431" mass="43741" checksum="C2F99E5F48E835DF" modified="2013-07-24" version="1">MNVEIGASSVQGTASAPPSKSYTHRAILAAGYADGAIVEDPLWSADTQATAGAVEAFGGTVERKANGDLSVTGFGGTPAVPDDVIDCENSGTTMRLVTAAAALADGKTVLTGDSSLRSRPHGPLLDAIEQLGGTAESTRGNGQAPLVVGGPIAGGTASIPGDVSSQFVTALLMAGAVTESGVDVDLKTELKSAPYVDVTREVLADFGVETAEVDGGYEVRGGQRYDPDGGSYAVPGDFSSMSYLLAAGAVAAPDGLTVTGARPSAQGDSAIVDILESMGADLGWDRDAGTIDVEQSRLSGVEVGVADTPDLLPTIAVLGAIGDGTTEIVDAEHVRYKETDRVSAMAEELEKLGASVTELEDELHVHGGESDLVGATVDGRGDHRVIMSLAIAGLVADGTTEITGAEHVDVSFPGFFDAMYDLGADVTRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1I2</accession>
    <name>R4W1I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447365.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12660"/>
    <dbReference type="EnsemblBacteria" id="AGN02471">
        <property type="protein sequence ID" value="AGN02471"/>
        <property type="gene ID" value="L593_12660"/>
    </dbReference>
    <dbReference type="GeneID" id="16181959"/>
    <dbReference type="KEGG" id="sali:L593_12660"/>
    <dbReference type="eggNOG" id="arCOG04625">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077072_0_0_2"/>
    <dbReference type="OrthoDB" id="92900at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="26828" checksum="D33B01396280197F" modified="2013-07-24" version="1">MELRGERECTDCGARWSYYDTGAIVCPECSSPDTVAVDEQRAVHTDSPVEFDLTPMRAAIDDLPRQELGEQTADACREYVRQRGFVSGGDLLPIDDTYLAARELAGVADTVRRAHSLTDDEEWYFLELLRGADAGERPDPEDVPESMWPVRGLAYANAVRDYRRDVRQWLDATDDVPGPAYAGEVLGTIEDHVRRMRALQGDVPPKQAEGLVVAARGLGSYLRAEDADGLALARETLDGLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1I9</accession>
    <name>R4W1I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk potassium uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447375.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12710"/>
    <dbReference type="EnsemblBacteria" id="AGN02481">
        <property type="protein sequence ID" value="AGN02481"/>
        <property type="gene ID" value="L593_12710"/>
    </dbReference>
    <dbReference type="GeneID" id="16180135"/>
    <dbReference type="KEGG" id="sali:L593_12710"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_3_2"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="227" mass="24386" checksum="CAA24552EF81DA83" modified="2013-07-24" version="1">MYVIVVGAGEIGAPLIDIAIQNGEEVVAIERDPERADEIADDFDCLVLNADGTVKETLEDAGAERADAIVATTDQDATNVMVSLLAQEFGVPEILSVVRNPEHMPLFERIGVHTMQNPQRLIARDLFRSLRLPSVEDYMRIGEEAEVFEITVDEGAPIAGKTLQGASEADLLGADVLIVAIERNGNGSPITPRGPTRIEPGDLVTVYSGSGATPELTDVFGHPEDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1S6</accession>
    <name>R4W1S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447490.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13285"/>
    <dbReference type="EnsemblBacteria" id="AGN02596">
        <property type="protein sequence ID" value="AGN02596"/>
        <property type="gene ID" value="L593_13285"/>
    </dbReference>
    <dbReference type="GeneID" id="16180503"/>
    <dbReference type="KEGG" id="sali:L593_13285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2718"/>
    <dbReference type="eggNOG" id="arCOG04511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043006_0_0_2"/>
    <dbReference type="OrthoDB" id="69099at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40839" checksum="AFCDE1725C1080D1" modified="2013-07-24" version="1">MTPDGARRDSRDDPSRRRYLESVAALGGASLAGCVDPGLGSSGDGENDGQPQFQQVENPPDVVYVPGHREGVEMLGTTTDGPYRFRAMVSYAHPFWIVTGSAVEPVEVSDAVDVHLMVAIEDAETGTVLPVDSGLTTTVHDADGRLVDSRSPWRMLSQTMGVHFGDNVPLDDDGTYDVAVEVPPMEARTTGAFDGRFDSAAATSFSFTYDQALRDRLIDRIRYVDDEQRGVPGAIDPMDGASGLPPASALPGTLQGTGESDGGSGSGEPSLPRSHDADAAVTVVDGFAGDDASYLLVSPRTPYNRFALSGAALSATIRRDGAVVAETDLLATVDHRAGFHYGATIPELSPGDDCTITFDAPPSMARHAGYETAFLSMDPVEVALEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1Y2</accession>
    <name>R4W1Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447570.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13685"/>
    <dbReference type="EnsemblBacteria" id="AGN02676">
        <property type="protein sequence ID" value="AGN02676"/>
        <property type="gene ID" value="L593_13685"/>
    </dbReference>
    <dbReference type="GeneID" id="16180776"/>
    <dbReference type="KEGG" id="sali:L593_13685"/>
    <dbReference type="eggNOG" id="arCOG07782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542526_0_0_2"/>
    <dbReference type="OrthoDB" id="131322at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="502" mass="53735" checksum="4606171C703BE0AD" modified="2013-07-24" version="1">MSAEQQEADWEQWVDFYADARQANADDSTQIEQAKRDAYGMKTAGRQDGLYAAYEVAISDGTLSQAKTAAKDAARARYSETLQGVYNHWTSRLTQVQEMMQLVNSSDFATSVNEVAETYAAGGGYSGYDGPHDAWTAFNSSWGTQSGTTVSSDLMPVITSLTNSDVTLPDGQTVTVPGGTEVKTSSYDNETSYFGAALSIDLGANAVHNYRNPPNGNADQAWFHTDVRIREPDPTLYDSVDSSEVDTSDFDGHKPIMNTRDFHALVAEIERMMQDTLSTLDSMVEAKFDGMKSGDVSLQDLVGSQAMWEAARNAENFREAALAFRSAGYYTADTPTVVEFERQDGTTVEVDAHLAVARTTDLDPLPVGSQVDASNIAGTVYMAYNEEDADGNVTGGAITSITGAFTIVAAEDGSSEVAFTRRGVIETSMSPTEIRKILEENGDAKADAEEARQDINVEGSSLFGGGIDLGGGNSLLWSLLAGLGSLGVAAVAFVIAWFVASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J9</accession>
    <name>R4W2J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC, inhibitor of MCP methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444896.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00235"/>
    <dbReference type="EnsemblBacteria" id="AGN00002">
        <property type="protein sequence ID" value="AGN00002"/>
        <property type="gene ID" value="L593_00235"/>
    </dbReference>
    <dbReference type="GeneID" id="16181234"/>
    <dbReference type="KEGG" id="sali:L593_00235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.47"/>
    <dbReference type="eggNOG" id="arCOG02381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654911_0_0_2"/>
    <dbReference type="OrthoDB" id="56884at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="434" mass="47308" checksum="EE6E11910C3EC0AF" modified="2013-07-24" version="1">MRLDTTALGTFHQMAREGAGIAAGRLTGIAEVEARVGITKLNFVRGEEIHKELAAGGEKVGVRVELSGAIEGHSMVVFDADSARRVLQTLLGDQFDDAAPEPEDGTTVGEAWAQDGVDADPAEFDELAESAMEEVGQIINSGFVDGWADVLETAIDMTTPEFVQGSDPEPFLEGLEAAPGEDDMAIMFRSQIEAVGEEIGFTHYLFPDHDDFAALLDRLRESDGIEYDKLVGFDRMAQRGAEEVADNISTMTGFDTEIELRRLNFVPMSAIPQELGNRRLVAVAFEFDGTPSGYLVFCFEEDSAETVVDGMLPTAPDDAFGEMGQSAIKELSNIMASGFLDGWANVLDTNIDHTPPEYSHDLGAAVMDPIVLQFGDSQDFAFVFDTHVQAADREFDVEIYAIPDEDDLERALSQLDVDRIDDEPIEAEFPIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2M7</accession>
    <name>R4W2M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447855.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15135"/>
    <dbReference type="EnsemblBacteria" id="AGN02961">
        <property type="protein sequence ID" value="AGN02961"/>
        <property type="gene ID" value="L593_15135"/>
    </dbReference>
    <dbReference type="GeneID" id="16181767"/>
    <dbReference type="KEGG" id="sali:L593_15135"/>
    <dbReference type="eggNOG" id="arCOG04547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104052_0_0_2"/>
    <dbReference type="OrthoDB" id="101847at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="24905" checksum="BEAF41F1861377F6" modified="2013-07-24" version="1">MHEAVSTLDARVPRPRKSTIVWGVVLVNVEALFVLTYLAITQRSYDLAFLLFPFVWINVGLWALVRTEPPSASTSRRRVAAGLSVLYFLALGFMGNMLALGPAFGSDTPATGFDFVMYGIQPPGWTPYLLFNSEFLHVSLIPPYVIGFAALTYLVYATVLDAASLAGVGIVGLFSCISCTMPLVAAVVTGAIGASSGALLSAVAPIAYEGGMVLYVVTVALLYYRPVMGDGPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2N7</accession>
    <name>R4W2N7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2249 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444946.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00485"/>
    <dbReference type="EnsemblBacteria" id="AGN00052">
        <property type="protein sequence ID" value="AGN00052"/>
        <property type="gene ID" value="L593_00485"/>
    </dbReference>
    <dbReference type="GeneID" id="16181666"/>
    <dbReference type="KEGG" id="sali:L593_00485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.99"/>
    <dbReference type="eggNOG" id="arCOG03928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146484_1_0_2"/>
    <dbReference type="OrthoDB" id="120887at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018720">
        <property type="entry name" value="DUF2249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10006">
        <property type="entry name" value="DUF2249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2249" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="8529" checksum="B1E5E26B6EEA73E7" modified="2013-07-24" version="1">MPRLDLRDVAPPERHPLVHETFDEMESGESLTLVNDHEPKPLFYEFQAEVDAFDADGYAVEQTGPNAFEAELPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Z7</accession>
    <name>R4W2Z7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rpl7ae</name>
        <name evidence="10" type="ORF">L593_01345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445116.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01345"/>
    <dbReference type="EnsemblBacteria" id="AGN00222">
        <property type="protein sequence ID" value="AGN00222"/>
        <property type="gene ID" value="L593_01345"/>
    </dbReference>
    <dbReference type="GeneID" id="16179858"/>
    <dbReference type="KEGG" id="sali:L593_01345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.274"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OrthoDB" id="114541at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="12702" checksum="653ED1D0E2470A9B" modified="2013-07-24" version="1">MPVYVDFDVPADLQDDALEALEVARDTGQVKKGTNEATKSIERGNASLVVIAEDVTPEEIVMHLPELADEKGVPFVFVDEQDQVGHAAGLEVGSAAAAVVDAGDAEDDVEDIAAKVEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W313</accession>
    <name>R4W313_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445141.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00247">
        <property type="protein sequence ID" value="AGN00247"/>
        <property type="gene ID" value="L593_01470"/>
    </dbReference>
    <dbReference type="GeneID" id="16180501"/>
    <dbReference type="KEGG" id="sali:L593_01470"/>
    <dbReference type="eggNOG" id="ENOG502N5HZ">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830668_0_0_2"/>
    <dbReference type="OrthoDB" id="143981at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="14021" checksum="D66E30B2D64384F0" modified="2013-07-24" version="1">MEHTEARYPVPNSGASLARRTTAAAGVAILALVVQAIVDALGVELGASGSTSPFQAAPLIGATVVAGVGAAIAYAAMVRFTNRPVRNFVAVEVAVFAVMLLPVFLAPPSGITATGQGLLVLYHLLVAGPLVGFIVGAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W332</accession>
    <name>R4W332_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445176.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00282">
        <property type="protein sequence ID" value="AGN00282"/>
        <property type="gene ID" value="L593_01645"/>
    </dbReference>
    <dbReference type="GeneID" id="16181346"/>
    <dbReference type="KEGG" id="sali:L593_01645"/>
    <dbReference type="eggNOG" id="arCOG06262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097418_0_0_2"/>
    <dbReference type="OrthoDB" id="81547at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045396">
        <property type="entry name" value="DUF6517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20127">
        <property type="entry name" value="DUF6517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="23399" checksum="FA21A50AC24B0CA0" modified="2013-07-24" version="1">MKRQGLLVLAVVGLLVTTGCVGLVLGDGLEMDSEPAAVSDEALAETGFQFSDHRTLWLNETVAVAGQEREINASAHATIYNRTTNLERFERDTGGFVVISTPDVSVAGESANPAARMSNRELVERFQGELESEVGQLGNLTKVSERTEPVLGYAAAVSVFETTTTIEGREVTLYVHVTKVQHEDDLVIGIGVHPEALAQQAPEIHRLLRGIEHPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W389</accession>
    <name>R4W389_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 8">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pgk</name>
        <name evidence="9" type="ORF">L593_02155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445276.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02155"/>
    <dbReference type="EnsemblBacteria" id="AGN00382">
        <property type="protein sequence ID" value="AGN00382"/>
        <property type="gene ID" value="L593_02155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180088"/>
    <dbReference type="KEGG" id="sali:L593_02155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.437"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OrthoDB" id="46017at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="429" mass="46446" checksum="AD5F20539C9BFE61" modified="2013-07-24" version="1">MAAFHTTDELDPGQRLLVRIDVNAPIEDGEVQSTRRFERHAESIRELLDAGHALAIMAHQGRPGRDTFTGLEQHAFILSDLVGEEIEYVPSTFGEEAVEAIADLEPNPDAASAGAEDAAGDADTTGEAILLENVRMTDGELPEEPPEVKAQTEFVRTLAKAFDGYVNDGYSVAHRSHASIVGFPEVMDSYAGPVMADEYEYNTSVERREFDGDVTMVLGGTKAEDVIAAMDHLEDTVDTFLLGGVVGELFLRARGHPVGHDLEDGPDLYDENYEKNEDLIADVLDRFGDRIETPVDLAYEDENGERAEHAVVDVEEKTVSYMDIGHETVEAYRPIVEDSAAVLVKGALGVFEDERFSYGTVEVLRAAGESDAFCVVGGGDTARTVPMYDLDPAGFDHLSIAGGAYLQALTGEGLVGVDALERAAERMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3A4</accession>
    <name>R4W3A4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">L593_02280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445301.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02280"/>
    <dbReference type="EnsemblBacteria" id="AGN00407">
        <property type="protein sequence ID" value="AGN00407"/>
        <property type="gene ID" value="L593_02280"/>
    </dbReference>
    <dbReference type="GeneID" id="16182634"/>
    <dbReference type="KEGG" id="sali:L593_02280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.462"/>
    <dbReference type="eggNOG" id="arCOG01433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_2"/>
    <dbReference type="OrthoDB" id="24741at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="52"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="41737" checksum="E1AA3895B4701251" modified="2013-07-24" version="1">MPADDGSFGSYGGRHVPPVMEEPLDHLTEAFENVVLGDDEFKANLHATLEEYAGRPTPLYHAKGLSDRFGAEIYLKREDLLHGGAHKINNTVGQGLLARAAGKERLIAETGAGQHGTATAMVGAMLDLDTEIYMGKKDVERQKMNVFRMRLMGAEVNEVTRGGEGLADAVDAALEDFAQNVEDTHYLVGSVVGPDPFPRMVREFQSVIGREAREQIQEREGRLPDACVACVGGGSNAIGLFHAFRDDEEVDFYGAEGGGEGADSKRHAAPLDTGTDDVIHGMQTRVIDEDVEVHSVSAGLDYPGVGPEHAMFREMGRAEYHAVTDDEAMDAFRTLSEEEGIIPALETSHAIALAEDLADEHDVIVVNCSGRGDKDMEQAAELFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3B4</accession>
    <name>R4W3B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445321.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02380"/>
    <dbReference type="EnsemblBacteria" id="AGN00427">
        <property type="protein sequence ID" value="AGN00427"/>
        <property type="gene ID" value="L593_02380"/>
    </dbReference>
    <dbReference type="GeneID" id="16181517"/>
    <dbReference type="KEGG" id="sali:L593_02380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.483"/>
    <dbReference type="eggNOG" id="arCOG01931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_4_2_2"/>
    <dbReference type="OrthoDB" id="57322at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="32807" checksum="1B1C02FE2D43740D" modified="2013-07-24" version="1">MPQDLPGVDEERLIDTHAHQPTSEFLHDAGGQMMEDAASKFGTNLETWDYETMREEYREAGIGRAVLLGWDAETNTGNPPVPNDYVAEVRDEYPDFFVGFGSVDPLKDDCVEEAIRCVDDLDLSGFKFQQIAQGFDPSDDAHDELWSTIEDLGVPVVFHGGNSTLGAGSPGGRGLKIRHANPMLIDEVAAEHPDLQILIAHPAFPWEKEQLAICQQKGNVYMDLSGWLPRYVDEQVLQYAGSLLSEKVMFGTDYPMLRPEDWLESFAEDTEYDEETQRKLLFENAEEFLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3W1</accession>
    <name>R4W3W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445646.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04005"/>
    <dbReference type="EnsemblBacteria" id="AGN00752">
        <property type="protein sequence ID" value="AGN00752"/>
        <property type="gene ID" value="L593_04005"/>
    </dbReference>
    <dbReference type="GeneID" id="16180786"/>
    <dbReference type="KEGG" id="sali:L593_04005"/>
    <dbReference type="eggNOG" id="arCOG03860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060475_0_0_2"/>
    <dbReference type="OrthoDB" id="56787at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="33515" checksum="12175DE687F1A275" modified="2013-07-24" version="1">MTEEDTDSLSDDSEAVFSVLGDETRLRILLELAERSQPDASAEPYAFSELRRAVSVDDAGRFNYHLDKLQDTFVKKTEDGYRPTFAGLNVASSIHAGRFGSSADVEPTETEYECPVCEDPLYARYEDESVRIECDDEHTWFAYPVPAGAATDRSMDELLDVTVRRTGANVELARNGLCHRCWGTIDARVVDPDGTFEELGTDWPRVDVECERCWLAYTVPLPIFVAQSPPVVAFYHEHGLGPEDAMLSERNALEDATAELEGSSSDLFEVTIELAADHLTIVVDREGQIQAFERTRGDSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Z8</accession>
    <name>R4W3Z8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylamine n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445716.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04355"/>
    <dbReference type="EnsemblBacteria" id="AGN00822">
        <property type="protein sequence ID" value="AGN00822"/>
        <property type="gene ID" value="L593_04355"/>
    </dbReference>
    <dbReference type="GeneID" id="16180915"/>
    <dbReference type="KEGG" id="sali:L593_04355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.886"/>
    <dbReference type="eggNOG" id="arCOG13959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_1_0_2"/>
    <dbReference type="OrthoDB" id="65476at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="32599" checksum="38C604EC160C53FC" modified="2013-07-24" version="1">MPRLDADRYLRRIGLDADAVAASDRDRELLARLQSAHARSVPFETLSICGHPHPDAGAGYDGEPIDLTTEWLYEKLVERERGGFCYELNGAFAWLLDDLGFDVQRCDARVASDDGGYGIPADHLTLVVDLDDGSSSREASGNRRADSSPHLVDVGVGAPVVRRPVPLDGSVVDNGLGVEWRLVAPQRPDADYRLEYREPASWSNEETEWTPRYILQDEARELSFFEAGCEYHSTAPDSHFTGDSIAMQATGEGHVTLSPGALTRTVRGETEKRDVEPEAYDRLLAEEIGIRLDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W424</accession>
    <name>R4W424_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445761.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04590"/>
    <dbReference type="EnsemblBacteria" id="AGN00867">
        <property type="protein sequence ID" value="AGN00867"/>
        <property type="gene ID" value="L593_04590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180938"/>
    <dbReference type="KEGG" id="sali:L593_04590"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.937"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_3_2"/>
    <dbReference type="OrthoDB" id="93242at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="15410" checksum="61E5CBEBD3D484BA" modified="2013-07-24" version="1">MDDLDREILSILRRDSRTPYTEIADEVDTSEGTVRNRVERMLEDGVIERFTVATHTGNIKAMIEVEVDVDVDTQAVSESMADWAQVDFVWMVSGEQDIVLVVDAPDTQGVNDLITQARELSEVVNTKTRLILDEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W457</accession>
    <name>R4W457_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04890"/>
    <dbReference type="EnsemblBacteria" id="AGN00927">
        <property type="protein sequence ID" value="AGN00927"/>
        <property type="gene ID" value="L593_04890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.999"/>
    <dbReference type="eggNOG" id="arCOG00895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="353" mass="38001" checksum="BECB86382233F202" modified="2013-07-24" version="1">MTPSSLAIGLPGLSNTVLQLFLVAVAVLVFAWGFERYRTNFSRTELAVATAISLGLLTVGVLPGIFGAIGGVLNVERRSLVVSLLANVAFAFLLLYALAMIRNNQLSISELTRQLAIRNVDGRAHDEPTVGVVIPAYNEAESVRGVVESLPGRVLGHRVEAIVVSDGSKDDTRAAAADADAIVTEHPINQGQGGALKTGFAIAQQHGADVVVTMDADGQHRAADLESLIEPILEDRADYVLGSRYLGEDDSGNSPTRRFGIRAFTWFINLVSKADVTDCTNGYRAIRGSRLDELTLTEERFSAPELIIEARKNGLRIEEVPVTIRSRDAGETKKPKLGYALGLTRTILVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4K5</accession>
    <name>R4W4K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446081.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06190"/>
    <dbReference type="EnsemblBacteria" id="AGN01187">
        <property type="protein sequence ID" value="AGN01187"/>
        <property type="gene ID" value="L593_06190"/>
    </dbReference>
    <dbReference type="GeneID" id="16181654"/>
    <dbReference type="KEGG" id="sali:L593_06190"/>
    <dbReference type="eggNOG" id="arCOG02702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2461907_0_0_2"/>
    <dbReference type="OrthoDB" id="103269at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9768" checksum="B5382DE8DB2992A4" modified="2013-07-24" version="1">MGDDDPWDELLVERGFHDVETATFDVERDWATDQIVDYVFSLSFASPEQFGADAEAFECDLRDRLDEGCDGGGSFEQSATITVHSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4M2</accession>
    <name>R4W4M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446091.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06240"/>
    <dbReference type="EnsemblBacteria" id="AGN01197">
        <property type="protein sequence ID" value="AGN01197"/>
        <property type="gene ID" value="L593_06240"/>
    </dbReference>
    <dbReference type="GeneID" id="16181690"/>
    <dbReference type="KEGG" id="sali:L593_06240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1275"/>
    <dbReference type="eggNOG" id="arCOG00888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287979_0_0_2"/>
    <dbReference type="OrthoDB" id="476at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121920" checksum="75638E51087A502E" modified="2013-07-24" version="1">MASTEPLSRTIADTVTISRELREEGEIDGQVKLYNVEDDEEFESDATTFFDRTLMTQGLREGFVDLRDTLRGDANYGTHILYGPYGSGKSHQMVAMYHCFADPDGAGAFGDQHIDGFSDALPASEESEAITVSLQQSQPEFLWEPFFDVLDYEPSESDLEPYPEMDVIQEAVDGRTVAYLMDELEDWFEPLSGDRKKRNRGFLQALLETADLDDSGVFAIVSVLRKGSDVHRILDRENASEVNMSSKVSKQEVIRHRLIDEVDEAAVADIVDGYVEAYAGNDHVPDSELPTDLADDMRDSYPFHPVLLQALETRYYADEGNQNTRGMIYLFSKILTTAADPEADPDDPDAAKLIEETDLVTHGDIDAVLFDDELTRINIDRPGVCVDDIRNRVDPDEIPYGRRILNTILLYSLKPDEGEGASKAEIVMGTYETNDLVSDIVLNLEQLYGVAWYLHKLNGKYAIRDRQNPNALIQNKASDVDEQLALEQIAQTVQTVFGDNAYPVGFTGSDLKDVPDNRDVKVVVSASDWTRDDVEKVIKNADRSPGREWRNTLVFVQPSGDKEIESGTGFIEKARYIEGAERVLKDESLDDEIRSSVKRQREDERRELQDRVELAYGEIIDGDDLLNEFDLAAEMDLDVFVSEGDPLNAADLTENVAAEGIDLQQHVWEIVDDLLDRRGEASIEDIYEQFLRQPTYPIPGGPSDVLEATVQTLEDKPVVTHGSNGFSESLKGSSLDTTILHERDVEQWTVEDVEQELRRRFGSGSDSIDVGNFELELLEDTEIWLEGDGHDTVMTAVGRVGKDDQYVLYSGTDIVSKAQSDATIRDISEAERIGVAEVRDRIRAQLEEQGRANTYRILEEIRSDGTIYLPGSQTEQAFREAVTDFLVDDYVIDVERRYYDSLGDRDPTDLVLVPDVSDDVGDEILDYLDDLDGGEEFTVGSVADRFDSTVSDDAVQTFLLRNLGRGEDPEYVIGTDGSGDPTRWSKGYQFRIPSGGWRFQFDGDDPAELRRKWRQEEDSGEVTFGEVRFTLMDKRGIPGPLQGTARIQETMTKLTIASGEDFTKVRELFEEMPSDASNISVEINFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4X4</accession>
    <name>R4W4X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446281.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07200"/>
    <dbReference type="EnsemblBacteria" id="AGN01387">
        <property type="protein sequence ID" value="AGN01387"/>
        <property type="gene ID" value="L593_07200"/>
    </dbReference>
    <dbReference type="GeneID" id="16182064"/>
    <dbReference type="KEGG" id="sali:L593_07200"/>
    <dbReference type="eggNOG" id="arCOG04726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082034_0_0_2"/>
    <dbReference type="OrthoDB" id="60104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="314" mass="31141" checksum="E4864829FB8AF8C1" modified="2013-07-24" version="1">MDIAEKRVYETSAGRSRLAVATAQGLAVVGISADVIGEFGLALRDPVRDVAALGDGRVLAATPEDLLVVALGADRVAETVGTVPTDAGPTDAVTITGDAVIAAGADGAVRRAPMASVLDAAPAADSGSATAVAWRAIGEADVRAAGGRLLAAADGVYRVDTDAIEHVGLDDVRDVAAPGGVEAVGPFAATADGLFRLGPGWVEEREGPFDVVAAAGESASAAGEPTADGEQRVHAASGKDLLARTDDGWTSTDWPARAPVAGIAYGTGDDAAGAEGTPPTFAVAADGTVLADAGDGWRTRSIGLPDVAACAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W534</accession>
    <name>R4W534_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446386.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07735"/>
    <dbReference type="EnsemblBacteria" id="AGN01492">
        <property type="protein sequence ID" value="AGN01492"/>
        <property type="gene ID" value="L593_07735"/>
    </dbReference>
    <dbReference type="GeneID" id="16182203"/>
    <dbReference type="KEGG" id="sali:L593_07735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1585"/>
    <dbReference type="eggNOG" id="arCOG02890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_2_2"/>
    <dbReference type="OrthoDB" id="36415at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="321" mass="34534" checksum="E0EC124A7A262B6F" modified="2013-07-24" version="1">MAGHHAERITLARLPAGTEIATTVHTYEGAGDGPTVYVQAAQHGQEINGTEVCRRLDDRLDPEELFGRVIVVPVANPLTFDRVSYTTPEALDGVNPNMNRVWPGDADGTIHEQMAARLWAFAGDADAIVDLHTGSVEMLTHAVYTAGDERARDLAIAFGTELLLAEPAGEAASDEWHERSFDGKLRVAAADAGIPAITPELAHNKQLVESAIEVGVRGVLGVLRELDALRGQRITSAEPTIARNHLGRVTADHSGLFRVTADVELGQRVPEGFQLGSVYHPTTYEPLQFVETDRAGVLYALTREATVNAGDRLASVAIDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S1</accession>
    <name>R4W5S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446801.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09810"/>
    <dbReference type="EnsemblBacteria" id="AGN01907">
        <property type="protein sequence ID" value="AGN01907"/>
        <property type="gene ID" value="L593_09810"/>
    </dbReference>
    <dbReference type="GeneID" id="16182816"/>
    <dbReference type="KEGG" id="sali:L593_09810"/>
    <dbReference type="eggNOG" id="arCOG02845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136034_0_0_2"/>
    <dbReference type="OrthoDB" id="78974at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="237" mass="26073" checksum="FB4B7321925259B8" modified="2013-07-24" version="1">MSEPHELLSVAPNADDATIRAAYRELLLEHHPDQGGSKKRFMQIKDAYERLVGDSRSGSITEPLSDGGATITPAGRCIEVAGKTVQGADGLELVAEADGLQVRLTTLTDRLPTGAMLPSHVESGRRVGACFHVTNESGRPVTWMARRVRFVGSQGERYLPTVYRPKRRKLPDRWRSDDVEIAPGDTARSFLLSRALPEDVAVETVVYDQQSGVGPARRVEFELDRAARSALDRPPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S8</accession>
    <name>R4W5S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446811.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09860"/>
    <dbReference type="EnsemblBacteria" id="AGN01917">
        <property type="protein sequence ID" value="AGN01917"/>
        <property type="gene ID" value="L593_09860"/>
    </dbReference>
    <dbReference type="GeneID" id="16182835"/>
    <dbReference type="KEGG" id="sali:L593_09860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2030"/>
    <dbReference type="eggNOG" id="arCOG04648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_2_1_2"/>
    <dbReference type="OrthoDB" id="111821at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="113" mass="12425" checksum="4B10BA4D086CAD81" modified="2013-07-24" version="1">MSFEPEPSLSPEEVQERVDAAIEQNEVVLFMKGNELMPQCGYSKRALGLIGQYRDDVATVDTLEALDAYREALEEHSGWTTIPQTFVGGEFVGGSDVLAELDENGDLEETLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T4</accession>
    <name>R4W5T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01927">
        <property type="protein sequence ID" value="AGN01927"/>
        <property type="gene ID" value="L593_09910"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2040"/>
    <dbReference type="eggNOG" id="arCOG02492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382046_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="724" mass="75735" checksum="EF5E93206CEDC640" modified="2013-07-24" version="1">MDADTGDEQWAFEIGDGVSESPTVVDGTVYVGAQDNNVYAVDADAGEEQWAFETGDWATSPAVVGGTVFVGSFDNNLYALDADTGDEQWTFETGDAVLSSPEVVDETVYFGSQDNNLYAVDAQTGAQQWAFEANRGVVGQAVVNGTAFVSSVDALYAVDAQTGGEQWTFEPSNFILGSPAVADGTVFVCVQDEGGLYAVDAQTGDEQWFFELGRIPFVVVSPAVADGTVYVGSGDEGKLYAVDAGTGEERWTFETHHQIGSSPTVVDGTVFFGSNDHSLYALDADGTGSSDVGDTETRENTGETEAGEERWAFETGGSVGSSPTVADGRLFVGSRDQYMYAVDAQTGDEQWAFETGDMIYSSPTVADGTVFFDSYDDNLYAVDVQTGGELWDFQTRGTVTSPSTVEEGMIFFGSRENLYGVDAQTGDYQWTFEAVISSAPTISDGTVFASSADDHLYAVDAQTGDEIWAFQTGGYVDSSPAVADGTVFVGSDDGNLYALDADTGDEQWTFETGDVIGSDPTVIDGTVFVGSRDSNLYALDAQTGDELWAFETGDFVDSSPAVADGTVFVGSKDHNLYAVDAQTGDELWAFETGDSIESSPTVADGKVFVGSNDSHLYAVDAGIADLSETGEDNTGDTETGGNSTGDTETGGNSTGDAETGGNSTGDTETGGNSTGDTETGGNSTGDAETEDGNSVPGFGIGSAISAIGATGYMLKRRLTDDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V6</accession>
    <name>R4W5V6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="12" type="ORF">L593_10085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446856.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10085"/>
    <dbReference type="EnsemblBacteria" id="AGN01962">
        <property type="protein sequence ID" value="AGN01962"/>
        <property type="gene ID" value="L593_10085"/>
    </dbReference>
    <dbReference type="GeneID" id="16180008"/>
    <dbReference type="KEGG" id="sali:L593_10085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2079"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OrthoDB" id="96453at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="11">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="134" mass="14814" checksum="3544765FA1431260" modified="2013-07-24" version="1">MDYEDKLDRALEETPDIGDESARLSVPDPEVRQEGNVTVYENFQDTVTTLSRDPEHVLKFLQNEVGTSAHIDESGRARLTGSFSERRVSDALDAYVEEFVTCSECGLPDTRLEKEKGTLVVRCEACGALSPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W695</accession>
    <name>R4W695_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-splicing endonuclease</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA-intron endonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">endA</name>
        <name evidence="5" type="ORF">L593_11235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447086.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11235"/>
    <dbReference type="EnsemblBacteria" id="AGN02192">
        <property type="protein sequence ID" value="AGN02192"/>
        <property type="gene ID" value="L593_11235"/>
    </dbReference>
    <dbReference type="GeneID" id="16182341"/>
    <dbReference type="KEGG" id="sali:L593_11235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2317"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791347_0_0_2"/>
    <dbReference type="OrthoDB" id="110254at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01834">
        <property type="entry name" value="EndA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023516">
        <property type="entry name" value="tRNA_splic_arch_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="253"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="347" mass="38030" checksum="92B397A748C14C10" modified="2013-07-24" version="1">MEARTEDGRVVIGGDARQRFYDARGYGYPLEGNEIAVSWVEAAHLLLRGDLDAVDGREFEAFLRDGAGDVTGGDRAALTFLVYLDLRERGFYCSPAREGWIDDPTDVVDFVVYPRGKGPVDDAVAYEVRVVGERESIPAADLGDCTLAIVDEESEVTYFETGRPSWEGTAAFEPGDPVDATLLADRAVCWDAPEALYGQAFYGQPLGKRDEGIDALQLSLVETAQLVAAGALDVEGGYDAVVDRGRAVEGDRFDRRLQVYAALRERGVVPKTGFKFGADFRTYSAVESVDDLGHSERLVRVVPGDFAFDPRDLALDVRLAHGVRKQLVVAWPEDASVEWVSIERLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G4</accession>
    <name>R4W6G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447191.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11770"/>
    <dbReference type="EnsemblBacteria" id="AGN02297">
        <property type="protein sequence ID" value="AGN02297"/>
        <property type="gene ID" value="L593_11770"/>
    </dbReference>
    <dbReference type="GeneID" id="16180949"/>
    <dbReference type="KEGG" id="sali:L593_11770"/>
    <dbReference type="eggNOG" id="arCOG09121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208830_0_0_2"/>
    <dbReference type="OrthoDB" id="130037at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6075" checksum="2EDCA298884CEBAC" modified="2013-07-24" version="1">MQRSVSRYDLLLAVIALPIALAGVLGAVSTLAMSTALAVGSVPATGGIGYAIFVEQPTQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K5</accession>
    <name>R4W6K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445342.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02485"/>
    <dbReference type="EnsemblBacteria" id="AGN00448">
        <property type="protein sequence ID" value="AGN00448"/>
        <property type="gene ID" value="L593_02485"/>
    </dbReference>
    <dbReference type="GeneID" id="16180462"/>
    <dbReference type="KEGG" id="sali:L593_02485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.504"/>
    <dbReference type="eggNOG" id="arCOG01861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381438_0_0_2"/>
    <dbReference type="OrthoDB" id="68882at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="21621" checksum="4399D00F8C48C8DC" modified="2013-07-24" version="1">MPDFESQVRDAFPTLDSVERDDLRDRIVEAWVLGLDRGGWRDIADIPYAWNIDEVSTVEHVHGVATIAVELAAQQRTLHGADPDLDTVLAAALLHDVGKCYEYTEFVDDDRLLDPDPTYAGDVIPHSLSSYALAHEVGCPIAVQRAIPHVIGEIPKRTLEAELVKEANAASSNAITQATMGITLEEWIDEYSQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L4</accession>
    <name>R4W6L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447291.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12280"/>
    <dbReference type="EnsemblBacteria" id="AGN02397">
        <property type="protein sequence ID" value="AGN02397"/>
        <property type="gene ID" value="L593_12280"/>
    </dbReference>
    <dbReference type="GeneID" id="16179840"/>
    <dbReference type="KEGG" id="sali:L593_12280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2526"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_21_0_2"/>
    <dbReference type="OrthoDB" id="65419at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <sequence length="438" mass="44222" checksum="356B132BD1F60D60" modified="2013-07-24" version="1">MSRGATDDGISLLQAVTIEVGLIVGGALFSLTGIAAGIAGPSVVLAFAVAFAIAILGLVPTAMLGATFPTTGGNYRYPAALVSRPLAFLSAWGLGISMLTGGLPLYALTAGQYLDAVMPVSPVVVGFAVLTLFFLVNLVGLKPAATLQVALFVGLVAAMGTFVAFGAPTVTTGNLTPAFPNGAIGAVTAAGVLYFVCLGANFVVDIGGEIRDATVTIPQSFAVSVPIVLLLYVSIGLVAVGSVGADAMAGETLAVPAETFLSGPFLTLFVVGGALFAIATSVNAVYMIAPKYLEVLAEDGLMPTAVSATNDRYDTPHWALTVVYVLSTAALVSPLPIGDLGALLGLGGAFLIVPVMLAAIVAIRTRPGTTDTIPLPGGAIAGMAVLAVPLNILLLVLLASQSPLIFAAWLASQAVGGAYYLLWTRTTDRATNAPTLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
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    <sequence length="293" mass="30025" checksum="FCBE5E0F5D1A1A9A" modified="2013-07-24" version="1">MIAESGIAFALVAAVAWGLVLFGSKRYFSQFRSVTFLSVAFAFAALWYAPVSAAAALSGSGSATLSTEVVAVVVGTIGLLTLAQYLMFKGIELGEVSYVSPITRVAPVFVVPLEVALLGEHLTPLQLAGVVVATGAVYVANYEGGDLLLPLRRAVTYTPGQLALGSALVLAALSVSQRYMLQELGVASTVWIGIKLAGAAVLLAPLGWVRAERTAIVAALPQFVVLGGVLALAEHFIGRSFATLSASVAAPIISVQSIVAVLLGGLVLREANLGIRLVAAVTAIGGITLVALP</sequence>
</entry>
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                <person name="Patrushev M.V."/>
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    </dbReference>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00558.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="202" mass="21841" checksum="4C865A99BEEBBA79" modified="2013-07-24" version="1">MSTDAAETEEAPDEEAAATADVPETEAELQARIEELEDTVATLESEVDDGPKKMTIIATKGTLDMAYPPLILASTAAAFGWDVVVFHTFWGLDILHEEKSSNLQLSSVGNPNMPVPNALAALPGMDKVTTKMMEKKIDDNNTATIEELIEVSLEQGVEMQACQMTIELMDYDEDAFYDDVTVGVGAATALEHMAESDVQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y7</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN00643">
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        <property type="entry name" value="Alpha_ANH_like_IV"/>
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        <property type="entry name" value="DPH6/MJ0570"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="arCOG00187"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="52"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="288" mass="31010" checksum="063EF0FCC94A58B3" modified="2013-07-24" version="1">MHGDVDVDDVRELVHAGHPRASEESVSMTTTSIAAGKCDRLGDIPMTQGVWASLFSGGKDSSWACYRALEEGLPVERLVTVHPGEDSYMYHVPATDLAELAAESIGIELVEVDPGDLDAAETVDSGAQGDAELEPLEAALAELDADLEASGDGGLAGITAGAIESEFQTSRIEAMAERLDVELFAPLWQRDPEELAAEMLDAGFEIRIIQVAAAGLGEDWLGRTLDREALDELRELGTEYGVHLLGEGGEFETLVVDGPHMDRRIELETSTVWEGTRGHLVIEDAWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W702</accession>
    <name>R4W702_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">L593_13390</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13390"/>
    <dbReference type="EnsemblBacteria" id="AGN02617">
        <property type="protein sequence ID" value="AGN02617"/>
        <property type="gene ID" value="L593_13390"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13390"/>
    <dbReference type="eggNOG" id="arCOG08151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207581_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="48" mass="5287" checksum="18777FD0142BB01F" modified="2013-07-24" version="1">MIHDVPDDEAEESTYECLQCGAIVTSETHPGECEECGGDFHNRAMSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W713</accession>
    <name>R4W713_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_03660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445577.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03660"/>
    <dbReference type="EnsemblBacteria" id="AGN00683">
        <property type="protein sequence ID" value="AGN00683"/>
        <property type="gene ID" value="L593_03660"/>
    </dbReference>
    <dbReference type="GeneID" id="16180766"/>
    <dbReference type="KEGG" id="sali:L593_03660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.743"/>
    <dbReference type="eggNOG" id="arCOG04299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_2"/>
    <dbReference type="OrthoDB" id="95523at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="374" mass="39899" checksum="E56F6102E2D7E547" modified="2013-07-24" version="1">MTSTPPIRLATRGSDLARTQAGSVQDALERRRRDAELVTVETTGDRLRDELIHRLGKTGAFVRALDEEVLDGSVDAAVHSMKDMPTEQPDDLVVAAVPERASANDVLVTPDGRTLEDLPEGATVGTSSLRRGAQLQAERSDLEIEPLRGNVDTRVEKLLAPSLQAERERRKEAAQAEDAGETERAAFEDWLANRSALEDRALDRPIETEYDAIVLAAAGLERVGLLDELQVQHLPRNTFVPAPGQGALAITAAAGSDVVDLLRTSLDHRPTRIATTAERIVLAELGGGCVAPLGVHATLQGAHVRVTVAAYSRDGSESVEMNRDLPAESYASAARSFAREVADAGAAELIEEAKRDASVEAAEDAAASATGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B1</accession>
    <name>R4W7B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447681.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14240"/>
    <dbReference type="EnsemblBacteria" id="AGN02787">
        <property type="protein sequence ID" value="AGN02787"/>
        <property type="gene ID" value="L593_14240"/>
    </dbReference>
    <dbReference type="GeneID" id="16181157"/>
    <dbReference type="KEGG" id="sali:L593_14240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2915"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_9_1_2"/>
    <dbReference type="OrthoDB" id="78372at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33087" checksum="3BCDDCD32AFE31C4" modified="2013-07-24" version="1">MHVVTLLPSATEIVAALGVDPVGTSHECDHPPGVADGPDITSTRIDAAASSESIDQQVAQADSGDGVYEIDADLLERLDPDLIVTQGICDVCAVDTVLVERVVEELDLDAEVLTTDPHHLEDLYEDVERIGAALGRDEAADELIAEFRDRVSAVEAAVGPIEERPSVAILDWMDPVMVAGHWMPELVEIAGGQYPLAEPGDRSTPREWDLVLEADPDVLVAAPCGFDLDQTRSNLGDLADRDGWSGLRAVRAGRSYAMDGHHYVNRPGPRLIDTLEHLAATLHPGRFDVPPADVVRPMSELIAPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B3</accession>
    <name>R4W7B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447686.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14265"/>
    <dbReference type="EnsemblBacteria" id="AGN02792">
        <property type="protein sequence ID" value="AGN02792"/>
        <property type="gene ID" value="L593_14265"/>
    </dbReference>
    <dbReference type="GeneID" id="16181141"/>
    <dbReference type="KEGG" id="sali:L593_14265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2920"/>
    <dbReference type="eggNOG" id="arCOG01172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053639_0_0_2"/>
    <dbReference type="OrthoDB" id="93701at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="278" mass="30578" checksum="8F351B653162FDE2" modified="2013-07-24" version="1">MARVPFGVSRLDSMIGGGAPTGSTVLLASEVGAGGREFLYTTAAMSGLAHADEELFDLYYGDLEGTARLPDSVQYLSFTDDRNAIVEEMEYTMDAELVDAATDAISFEDLSEEYFQLSQVPSDWYAGTTPDITALGDRHDRRDVLDAIGEYLTREGEGSLVVIDSVTDLISVASGEMDWTDITLLIKGLTKAAKKWGGMVVLLVTLETLEDTELGRLMEATDGTLLFEWETGGSERARTMVVKQFRGVLSRLEEEEIIRFETEIHDGGFDISDVRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C8</accession>
    <name>R4W7C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00898">
        <property type="protein sequence ID" value="AGN00898"/>
        <property type="gene ID" value="L593_04745"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.970"/>
    <dbReference type="eggNOG" id="arCOG07919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172992_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="39" mass="4488" checksum="67888CA0923CA019" modified="2013-07-24" version="1">MTEGATKQEEERADDHLADVEEGAGCTEIWEHLSERREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D0</accession>
    <name>R4W7D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445797.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04770"/>
    <dbReference type="EnsemblBacteria" id="AGN00903">
        <property type="protein sequence ID" value="AGN00903"/>
        <property type="gene ID" value="L593_04770"/>
    </dbReference>
    <dbReference type="GeneID" id="16181069"/>
    <dbReference type="KEGG" id="sali:L593_04770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.975"/>
    <dbReference type="eggNOG" id="arCOG02331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="269"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="463" mass="51550" checksum="9C571D0127B8C241" modified="2013-07-24" version="1">MDEGTYRVLVEELPDIATIADPDGRITYVSPTVERTLGYEPDELLGEVGYEFQHPDDREAVAAAFERLLESPDTVETVETRWRHADGTWCWIEASLQNRLDDDVIDGILINSREISRRKRREEQYRELAEEYRTLLDNAEDAIFFLSVDTDGSEVAFRFERLSPSYEAQTGLTTSETRGKTPVEVFGDEAGAELAANYERCVEAREPISYQEELYVEEGARFWQTNLAPVLTNGEVTRIVGITRNVTDRVERERQLRAKTKQLDQFASVVAHDLRNPLNVAQGRAALLGEEFDSEHVEPLLGALDRMESLIEDTLTLSRQGQVVADPEPVELVDVVGSSWQSVATEDATLEIVAGGTISGDANRLQHVFENLFRNAIEHGDADCTIRVGRIDDTEFYVEDDGPGIPDDRKDTVFEWGTSSAADGSGIGLTIVERIAEAHGWTVDVVDAADGGARFEFSGVAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7M3</accession>
    <name>R4W7M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrolipoamide dehydrogenase</fullName>
            <ecNumber evidence="5">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445942.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05495"/>
    <dbReference type="EnsemblBacteria" id="AGN01048">
        <property type="protein sequence ID" value="AGN01048"/>
        <property type="gene ID" value="L593_05495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180612"/>
    <dbReference type="KEGG" id="sali:L593_05495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1122"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_2"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="340"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="48253" checksum="76AABECC4C0F025E" modified="2013-07-24" version="1">MADFDVLVIGGGTGNNVAAAAADAGLETALVEPGPLGGTCLNRGCNPSKMLIQAANAVHDVRDAERFHVDATFEGIDHAVVVDEMDELLGGIAADMETRYRERDHLTLFDERTEFVDERTVELGGEAVTAEKIVIAAGSRPVVPPIDGLADVDYLTSQDALYRRTTPESLVILGGGYIAVELGYFFDAMGTDVKIVEMMDSLVHREDADVAGAFTELAADRHDVYTGHRVTAVEEADESYAVHAETEAGEATTVEGSEVLVALGRRPNSDTLALETAGIEVDDRGFVETNEYLETTAEGVWAQGDVAGNALFKHSGDYETRHTIANVVDEERRTLDLSAMPHAIFTEPQIAGVGATADDLDEEGSEYVTGRADYADSAMGRAKKLDHGFVKVLADPDGEILGAHAIGYEAATLLHEAVVAMRTGATVEDVGGTIHAHPTLSKVVEAAFRDVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7M8</accession>
    <name>R4W7M8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="2">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rrmJ</name>
        <name evidence="2" type="synonym">rlmE</name>
        <name evidence="4" type="ORF">L593_05545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445952.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05545"/>
    <dbReference type="EnsemblBacteria" id="AGN01058">
        <property type="protein sequence ID" value="AGN01058"/>
        <property type="gene ID" value="L593_05545"/>
    </dbReference>
    <dbReference type="GeneID" id="16181417"/>
    <dbReference type="KEGG" id="sali:L593_05545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1133"/>
    <dbReference type="eggNOG" id="arCOG00079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_4_4_2"/>
    <dbReference type="OrthoDB" id="105478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="270" mass="28968" checksum="CFE596B4D2788922" modified="2013-07-24" version="1">MPGKDEYYNRAKVEGYRARSAFKLRQLDETAGLFGPGNVVVDLGAAPGGWLQVAAERVGPDGAVIGVDRQRIDDLEDPEPRVELLRGDVTEADTRERIREIAAEVAGADPSADTATGAVDVVLSDMAPNVSGEYELDHARSVHLARQAFETAKSVLAPGGDFVAKVFQGQDLEAFKADVDEAFDYARTVVPDATRDSSSEVYVVGKHRITAPVAAGETYTVDVTDEGSEGDGVAHVDGFTLFVPDAEVGESLEVRIDEVKPRFAFAERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T1</accession>
    <name>R4W7T1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ORF">L593_06145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446072.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06145"/>
    <dbReference type="EnsemblBacteria" id="AGN01178">
        <property type="protein sequence ID" value="AGN01178"/>
        <property type="gene ID" value="L593_06145"/>
    </dbReference>
    <dbReference type="GeneID" id="16181643"/>
    <dbReference type="KEGG" id="sali:L593_06145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1255"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OrthoDB" id="36053at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="45"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="37695" checksum="65C0EBE0155FB2D1" modified="2013-07-24" version="1">MSDADGPKQVDDPDYHNVNHTAAQTCGWTKNALTGDGTCYKHAFYGIRSHRCIQMTPVVKCNERCVFCWRDHAGHAYELEGVEWDDPEAVVDASIELQRELLSGYKGNDNVPDDRFEEAVEPRHVAISLDGEPTLYPYLPELIEAFHDRGLTTFLVSNGTRPEVLAECDPTQLYVSVDAPDRWTFDQTVKAVEDGAWEQLIDTMDVLAEKDETRTVLRTTLVDGHNMRDPDWYAAFYQRADPDYVELKAYMHVGHSRGRLDRSNMPEHEDVVAFTEDVMEHMPEHDVLKDRPPSRVTLISREEDTWVPKLQAGAEFWNAPDPSERAAVTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V0</accession>
    <name>R4W7V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06330"/>
    <dbReference type="EnsemblBacteria" id="AGN01213">
        <property type="protein sequence ID" value="AGN01213"/>
        <property type="gene ID" value="L593_06330"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1291"/>
    <dbReference type="eggNOG" id="arCOG08104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092407_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014948">
        <property type="entry name" value="BrxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023137">
        <property type="entry name" value="BrxA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08849">
        <property type="entry name" value="DUF1819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="28048" checksum="29E1BF32E69FA142" modified="2013-07-24" version="1">MCGLLVDRTEELARLYREHGSWNQVKQVWFDEWRSNRSTRGSAQKIFRVLTSRLQNPPGSLPAPSELPDVLDACATTRDKAQVVYLYLVADDPLVRYVVEAYSRYLTEDVTNSLDFSNSTLTEVLDRLEYEDGSSFDYADSTTVRWCEGFRSVMREIGVLEDQQAVTGSSPSTGDVPLLVAMGYSYEEGGDDWLECPIGLCYLFQAGSRWEEQFDRVGATDDWEFVELHGSLELRPVDGTYDWVGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y4</accession>
    <name>R4W7Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445058.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01055"/>
    <dbReference type="EnsemblBacteria" id="AGN00164">
        <property type="protein sequence ID" value="AGN00164"/>
        <property type="gene ID" value="L593_01055"/>
    </dbReference>
    <dbReference type="GeneID" id="16181570"/>
    <dbReference type="KEGG" id="sali:L593_01055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.216"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="26557" checksum="A1A278B836F1D997" modified="2013-07-24" version="1">MAEDASERFGIEGQRAIVTGASSGIGRAIAEQFAAAGADVVVCSREQENVDPVAEGIAESDRPGEALAVECDVTDRDAVEALVDATVEQFGGIDCLVNNAGASFMAAFDDISPNGWQTIVDINLTGTYHCTQAAGEALAEGGGTVINLASIAGQDGSPHMSHYGAAKAGVINLTSSLAAEWADRDVRVNCIAPGLVATPGVASQMGITAEEVDRSEVDRSIGRSEEVADLAQFLASPASSYMVGETVGIAGVPRISEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W824</accession>
    <name>R4W824_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445133.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01430"/>
    <dbReference type="EnsemblBacteria" id="AGN00239">
        <property type="protein sequence ID" value="AGN00239"/>
        <property type="gene ID" value="L593_01430"/>
    </dbReference>
    <dbReference type="GeneID" id="16182732"/>
    <dbReference type="KEGG" id="sali:L593_01430"/>
    <dbReference type="eggNOG" id="arCOG09246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076129_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="27600" checksum="C9C7275341B38273" modified="2013-07-24" version="1">MIAPASFQPIQHAGQPLLAPLQTSPAPDVGTAVVSIVGAAMLTLLSLRLTFLAVRTRTSVARPQAALWEYFGFAGVVGVLYGSFTLLQHWLDVRLDFLNGLLLAFTVLFALAMREAYFNTTLANAELDRLGEYRLRRALEIGFVAIVLVISVGPLVRRSRIFTVLTAAAGFTVVGYGLYFQFRRSRTPATRGTLIDTLLRQTVPVLVFAGGALVAPALALGVASPTVASAVAAVFVVVTAASLMTVTIKLSQHLSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W837</accession>
    <name>R4W837_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin/lipoate A/B protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445173.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01630"/>
    <dbReference type="EnsemblBacteria" id="AGN00279">
        <property type="protein sequence ID" value="AGN00279"/>
        <property type="gene ID" value="L593_01630"/>
    </dbReference>
    <dbReference type="GeneID" id="16179888"/>
    <dbReference type="KEGG" id="sali:L593_01630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.331"/>
    <dbReference type="eggNOG" id="arCOG01939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_5_0_2"/>
    <dbReference type="OrthoDB" id="47035at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="39"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="31661" checksum="9E9C8838E3CCC9C3" modified="2013-07-24" version="1">MTTELGPLADREWRLIPEESRTGPMQMALEEVAAETAVAGGPRTVRAFRWEPSTLSLGYRQEPHTVDWDYCEAEGIDVTRRQTGGGGIYHDHDADISYSVIAPADELPGDLMETYAMLCSPVLHAFDRMGVDAAFADAEQPAIHEPTCYLRAINPAHDIVATPSNDPDGASTEATPKKLSGNAQYRQREAVIQHGSLSYALATDHHLGVFADPGIDEERFRERVTSLREQAGVSRADAVDHLEAALTEWADAEVGQWTDAELDRARELAETKYASESWLRERVVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W867</accession>
    <name>R4W867_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsY</name>
        <name evidence="7" type="ORF">L593_07915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446422.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07915"/>
    <dbReference type="EnsemblBacteria" id="AGN01528">
        <property type="protein sequence ID" value="AGN01528"/>
        <property type="gene ID" value="L593_07915"/>
    </dbReference>
    <dbReference type="GeneID" id="16182009"/>
    <dbReference type="KEGG" id="sali:L593_07915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1621"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_1_2"/>
    <dbReference type="OrthoDB" id="38537at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="385" mass="41268" checksum="D19693E7EAEE1188" modified="2013-07-24" version="1">MFEGLKDTLGSFREDAEEAAEENVEEVDQDELEEAEEFEDADESERTAGDVVSENAGPTDETAAASEAGVAEAEPAASEEETDSDADDEPDTGFARKAKNLVRGQFVIEEDDLEGPLQDLEMSLLASDVEMDVAKTLLDNIRDELVGETRTVTTSTGAVVEEALENALLDVISVGQFDFEQRVQEADKPVVIIFTGVNGVGKTTTIAKLSEYFADRGLSSVLANGDTFRAGANEQIQEHARRLDRKLISHEQGGDPAAVIYDAVEYAEANDVDVVLGDTAGRLHTSDGLMDQLAKIDRVVDPDMTIFVDESVAGQDAVNRAREFDDAAAIDGTILTKADADSGGGAAISIAHVTGKPILFLGTGQGYDDLERFDPEWVAEQLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W895</accession>
    <name>R4W895_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445338.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02465"/>
    <dbReference type="EnsemblBacteria" id="AGN00444">
        <property type="protein sequence ID" value="AGN00444"/>
        <property type="gene ID" value="L593_02465"/>
    </dbReference>
    <dbReference type="GeneID" id="16180226"/>
    <dbReference type="KEGG" id="sali:L593_02465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.500"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643438_0_0_2"/>
    <dbReference type="OrthoDB" id="17847at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="192"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="426" mass="48086" checksum="8DE26ED7B2C5C2F1" modified="2013-07-24" version="1">MPMYDRNFMEGTRGTMAVDWEERIDVQRLRRERYERALERLRDSDLESMLLIDDPNVRYVTGLAMTGGSGADHYTLLTTDGDVVHWDTADHASNQRFNCPWLGDVRYACPGLGNVPRASGSATARRWLREQMAETVHEAMSEYGVADDPLGIDVAHAGLVAAFEDRGVTVDTEAASEAMLDARKTKTRDEIECLRQVASICEAGFQAIVENARPGRRESEVWGDAVRELWRHGAMVQGGYLTSGPNTWPKHQANTTDRAIRPGDLVYADFYNVGYLGYRSCYYRTFSVGEPTAAQEKAYERARDDLYDVLERIEPGATTDEICEGFPDMEGEHAGWYDADEHWQLTTNHWAHGLGLQLYEPPLIWRGVSPDHPIEIEEGMTMAVETQQPADRQGVRVEEMVVVRENGVEILSQWPVEEITQIDHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F8</accession>
    <name>R4W8F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-guanine transglycosylase, various specificities</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeosine synthase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446622.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08915"/>
    <dbReference type="EnsemblBacteria" id="AGN01728">
        <property type="protein sequence ID" value="AGN01728"/>
        <property type="gene ID" value="L593_08915"/>
    </dbReference>
    <dbReference type="GeneID" id="16180276"/>
    <dbReference type="KEGG" id="sali:L593_08915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1829"/>
    <dbReference type="eggNOG" id="arCOG00990">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029831_0_0_2"/>
    <dbReference type="OrthoDB" id="21064at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="537"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="605" mass="65923" checksum="CA7225F9952BFC15" modified="2013-07-24" version="1">MTEYFEIHERDGAARLGELRLADPLRTPALVDDVLEDAGSLWSADRALPTGEEANGPAGTDDALTILPHRGLPAGTDPEVQSSFAPEYPQVDFPSAAVVHQDTAADLGQDAYVLSSAQGVVGHAAAFAEALVETREAIQPDSALYLPGVATPGNVATLVYAGVDLLDTDRAVIRGTQGRYLTTDGETWLEDFDDADELPCPCPACQQPAGTFDREDCVEHNVAALRAEVARVRAKIRNGSLRDYVEGQARHEQWHTATFRRLDQQWAYLEERTPLVRRGEITAASEDTLRRVEIQRYADRVTSRYRPRFDDYPLVLVPCSASKPYSDSQSHRQFHDAIDYRGHVVSITSPIGVVPAELELTYPAQHYDSVVTGEWSATEVEFVATVLAAYLERADYPRIVAHVPEDYRPIMERAIAELGDGADSLSVEYTVADHPTTEESLGNLDAALDGELRYSKGQRYRSIVRGIADYMLGDGAGDDVFDDVVVHGRYPKLQVDRADASERSDEGQLAAVVPQYGTLAFTLEGARAWTNSGAPVKRVEIDEFVPHGSALAPGVVDADDEIRPGDEVIVEGPLAFGVGRAAMSGPEMAASTRGVAVDVRHVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N7</accession>
    <name>R4W8N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase/aspartoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445673.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04140"/>
    <dbReference type="EnsemblBacteria" id="AGN00779">
        <property type="protein sequence ID" value="AGN00779"/>
        <property type="gene ID" value="L593_04140"/>
    </dbReference>
    <dbReference type="GeneID" id="16180081"/>
    <dbReference type="KEGG" id="sali:L593_04140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.842"/>
    <dbReference type="eggNOG" id="arCOG02890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_1_2"/>
    <dbReference type="OrthoDB" id="28939at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="37231" checksum="D42EB0E63FDE4124" modified="2013-07-24" version="1">MPDAADFTFSGGKVEPGDTANLRFTVSETYLGDPVRIPVTIVNGAHPGPTVSLTAAAHGDELNGIEVVREVAHDWNHDDLHGTLVCLPVLNVPGFLAQQRYLPIYDRDINRSFPGDAESTSAKRIADSIFRNFIDPCDLGIDFHTSTRGRTNMLHVRADMADESVSRVARGFASNVIIDSEGPSGSLRREASEAGVPTITVEMGEAHRFQRGLIDRALTGVASVFAEFGLHPDAPVKWPGWRTVIEESANKTWLRADVGGIVDMHAKVGGLVREGESICTITSPFKMEDEVVEAPFTGLLVGVLENPVVYPGNPLCHVVKLTGDTLRALQKQQEDDIDGDGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q5</accession>
    <name>R4W8Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446897.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10290"/>
    <dbReference type="EnsemblBacteria" id="AGN02003">
        <property type="protein sequence ID" value="AGN02003"/>
        <property type="gene ID" value="L593_10290"/>
    </dbReference>
    <dbReference type="GeneID" id="16181531"/>
    <dbReference type="KEGG" id="sali:L593_10290"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2121"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OrthoDB" id="106121at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10903" checksum="0438059CB32CC6E5" modified="2013-07-24" version="1">MEQALWYLFVGTRGGSTRVAIVRAIDERPRNANRLAEAIEMDYNTVRHHLEKLEEHDVVEQGQEGYGALYFLTDRFDAHREEFHEIVRDEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T0</accession>
    <name>R4W8T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445793.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04750"/>
    <dbReference type="EnsemblBacteria" id="AGN00899">
        <property type="protein sequence ID" value="AGN00899"/>
        <property type="gene ID" value="L593_04750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181080"/>
    <dbReference type="KEGG" id="sali:L593_04750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.971"/>
    <dbReference type="eggNOG" id="arCOG02936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_2_2"/>
    <dbReference type="OrthoDB" id="62240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="320" mass="36432" checksum="6B482E261FB65A0C" modified="2013-07-24" version="1">MLEDRQVERSRAIQRRTGPTFYFATKFLPERVREPTHVLYAFFRIADEVVDDAEVIDRPAEDKRQALESFRAEALGETEPSDPVLEAFREVKDAHDIPDEEVNAFVDAMETDVEKKRYADVTELREYMRGSAAAVGAMMTAIMEPADRDRAMPHAKALGEAFQLTNFLRDVREDVVDRDRIYLPLRTLERHGVDPDQIAALEFDAGIAAAIREELHRTERFYRHGVAGIETLPDDCQFPVLLAAVLYADYHRSIRADDCDVITSPPTLSRRRTLSLFARTRARWQFNKDPAAVFDAVSPISMPAREDRDPTGEPLTLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U2</accession>
    <name>R4W8U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04900"/>
    <dbReference type="EnsemblBacteria" id="AGN00929">
        <property type="protein sequence ID" value="AGN00929"/>
        <property type="gene ID" value="L593_04900"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04900"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808027_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="343" mass="35871" checksum="A5A09B59E28ABF05" modified="2013-07-24" version="1">MNRKRLVTAAKFLVGVALLGWVLSSVDWGTLQDDLARLDAWVLLAVLAVTALEFGTRFAMWHALLRSVGRRSTRTVAEVDLSIKFINHVVPSKAAGHAVAPLVLRHFADLEWSDAVGIAGSNTALYSLIYGLTAIVGLAVFALDLPLWLLVGIAASTGLYLLAAVAIWGTGFGAGRRYGQRLLAIGASVPLVGSVVARAAGALPAIAGPARETFQVTVTNPRGIVEYALAMAGTIAVFPAIRVGLLLAAFGEPFEPVVLLPIALVTAYSLTIMPITPGGVGVAEFSALYVFVALGVPETAIVSAIVIDRFLGVYLPAFIGWLPMMNVDFGSLVRGEPAGGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U5</accession>
    <name>R4W8U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_04950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445833.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04950"/>
    <dbReference type="EnsemblBacteria" id="AGN00939">
        <property type="protein sequence ID" value="AGN00939"/>
        <property type="gene ID" value="L593_04950"/>
    </dbReference>
    <dbReference type="GeneID" id="16181145"/>
    <dbReference type="KEGG" id="sali:L593_04950"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_3_2"/>
    <dbReference type="OrthoDB" id="41033at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="8">
        <location>
            <begin position="371"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="539" mass="57179" checksum="10E87A78421E3356" modified="2013-07-24" version="1">MNEKQPTDDLNDVDENRIPGEAPASADTTKSSLTKDQAVRDVVKGAGVVYGGLVAQMALAFLAQRFAAVHLSISGFGGLTTGTALLNLGGIVAGLGLSSGLTRYLPRVEEEEKRPIVTYLFALTIPIGVGLAAVTVLYADFIAAEMFGDAGVAVSIQVFGAAIPFAAIMNLAIGGIRGQKISRFRVYVRNLLHPASRFALIIVAVFVGADQAGFAFAYAIPFVVGAAIASVLFERTLPEASDWDGGRERLSEIIRYSLPFTVSGLASFVYRSIDIFLLLYFVGSTAVGIYGVAYAMAQMMGMFSTAFNYLGTPVSSELESENRLDEAITVQRGVARWLAIASTTALIPMVLFADDLIRIIYRSGYSEGGLALAILAVGFALKNVLLTHGPLLEALGLSKLSAVNTTSAALVNFGLNLWLIPRYSFTGAAIATTISLFVLGLLPVIEIAYYSGSTAIGWNVIAPVVLAIPIGIIAFIVSSQIPATILWITIFGVGFAGCYGAAIIGILGFTPTEVMILHSIQDKYVSDNTIINKILQRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W3</accession>
    <name>R4W8W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447032.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10965"/>
    <dbReference type="EnsemblBacteria" id="AGN02138">
        <property type="protein sequence ID" value="AGN02138"/>
        <property type="gene ID" value="L593_10965"/>
    </dbReference>
    <dbReference type="GeneID" id="16180749"/>
    <dbReference type="KEGG" id="sali:L593_10965"/>
    <dbReference type="eggNOG" id="arCOG08021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187344_0_0_2"/>
    <dbReference type="OrthoDB" id="125915at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="7893" checksum="675EB76D66BE9074" modified="2013-07-24" version="1">MATQDDPRLEPLPAELDSPRAKLVYFTLAVTGGASVGELHDVLDVPKLTLLSVMDALTGRDLVQRTDDGFVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W4</accession>
    <name>R4W8W4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps2P</name>
        <name evidence="5" type="synonym">rps2</name>
        <name evidence="8" type="ORF">L593_05200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445883.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05200"/>
    <dbReference type="EnsemblBacteria" id="AGN00989">
        <property type="protein sequence ID" value="AGN00989"/>
        <property type="gene ID" value="L593_05200"/>
    </dbReference>
    <dbReference type="GeneID" id="16181271"/>
    <dbReference type="KEGG" id="sali:L593_05200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1062"/>
    <dbReference type="eggNOG" id="arCOG04245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="OrthoDB" id="63341at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="27655" checksum="9444EF0BE88F6B08" modified="2013-07-24" version="1">MSNNDNEMEGLDAEEAEADEASAAEATEEPTDAPDAADADAEAAEAEDEAAADEPQLDDDVLGDEEADLLIPVEEYLGAGVHIGTQQKTSDMERFIHRVRTDGLYVLDVAQTDGRIRTAADFLSGYDPEQVLVASSRQYGQFPAEKFAEAIGARARTGRFIPGTLTNPKYDGYIEPDVVVVTDPIGDAQAVKEAITVGIPVIAMCDSNNATSNVDLVIPTNNKGRKALSVVYWLLANETLDRRGAEPTYALDDFEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W968</accession>
    <name>R4W968_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446108.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06335"/>
    <dbReference type="EnsemblBacteria" id="AGN01214">
        <property type="protein sequence ID" value="AGN01214"/>
        <property type="gene ID" value="L593_06335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181703"/>
    <dbReference type="KEGG" id="sali:L593_06335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1292"/>
    <dbReference type="eggNOG" id="arCOG05219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264496_0_0_2"/>
    <dbReference type="OrthoDB" id="8397at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1264" mass="141728" checksum="F3058E5A86A7B243" modified="2013-07-24" version="1">MVDSTWFSDLPDEFEESVRIDRQDRSEESFRHRTQAIESYHVTSDSQAFLEDVVERTLDEAEDMRTGSNYWLYGYYGSGKSHLLTVLEGLMDSSWVAGQYEEVWSDLVPAAAEGRNLETLRERWEDVHADYHVIPVSVNLLKYQGQKKRSFSEIVLRHAHQHPTLTGVDNGISTGLSAQLGVAYFEDWYRTTPAWDDRQALAADVVEEVVPDTPRYDWPEEQLWKDIQQYSALSDVVLPALFEGVQGTRDGYTDLQPSDIDPNEVVSRLESLRQEREETMGTPVKLVLLLDEVSLFIGTDFERLTELQTLAENVDDIGDGNIQLVATAQAKIEDVQPKFAAHGADFSIVKDRFPHRYQLPSKHVGDIAKRRLFAKSETGEASVRQVLDEADVKPGESLVYNDIRQNTKPPLDEIDEEALVEYYPFLPYHAPLFLEILFNLRREANDPAKSIFSGTARAILALMHGLLEEWIEEGEDDTIVTLVDFFDLIEPELREILSSDMRVIEGSNPSPDAEDGSHAASTGEIATSIVAEVNDTEREIREFDLKVAKAVLLLRQVNEIVPLNEGNIAVAVMSDLNGRSWISTTNRVEDSLDRLEKYIRPTEDGSSPRYRFATQEERLIYHDAEENEANPNWDEIVEALDEHLWADIARELSLPDSAPYKESGAEYPVSYHFEVDGVAFSTSQTADGGLDVDIAIHGIRPDVTTDQDDPDVLHWEIDSDGLQDLRESIVDWWALRNAIASHDVPPAVEQDLDRRSASVRSKLVSAMSGGSYSVNDRTDISGLSTAVQETVDVSYPDDFHPMLLQVDESRLRELRELDSDAVLPQWAEAIQVPTADHGGDDRNQTIRRNVMSLTGRQLHGRDEGLTLETILDGIVEKKPFYSDARPALCAIIWGLCRRGRLVAVDEAGNTLDDEAVLDIDTTATTRLQLLSSDQLGNLLETGGFKETTDTVAEGLINLQEENRRIHSTLRGLHEDVTLIAETDVRADEVGALLDAFADELAERMEDTKGRIAVVKSQSGDLEGVIEGTNEVGEWLSDVTDVWNRRLSQLQQLDAVLTIGDRDFEWIDDDAQRAIETRSESVASYDGEWWTAEGWKTFSEQLVPDLAPELGRAWQEFVDQGDIDALVERIDDNPWILPATSLPTGVHASFERTYITPMRQFVRWFETLDEALTTLPSDSDAGAYVEIADDTMALEPMADAFDDGPEDLAAKLDGLSAIVGERTPDDVDQIGIVPSDRDKLQRRLERLAEDGDLDVEDSGQGVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W985</accession>
    <name>R4W985_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446158.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01264">
        <property type="protein sequence ID" value="AGN01264"/>
        <property type="gene ID" value="L593_06585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181885"/>
    <dbReference type="KEGG" id="sali:L593_06585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1344"/>
    <dbReference type="eggNOG" id="arCOG03909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155662_0_0_2"/>
    <dbReference type="OrthoDB" id="127417at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="12631" checksum="87C26A809035C206" modified="2013-07-24" version="1">MATDDTILRAAVIVVAAFLLIPFLMLLFAVPMLGMSGGHMWDGGGMSDGAGWAWVGSWLVMLAVIGLIGYAIARALRGPKRTSTDPAIEELRMAYARGDITDEEFEERRERLESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A2</accession>
    <name>R4W9A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446208.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06835"/>
    <dbReference type="EnsemblBacteria" id="AGN01314">
        <property type="protein sequence ID" value="AGN01314"/>
        <property type="gene ID" value="L593_06835"/>
    </dbReference>
    <dbReference type="GeneID" id="16181890"/>
    <dbReference type="KEGG" id="sali:L593_06835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1396"/>
    <dbReference type="eggNOG" id="arCOG00499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_2_0_2"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="274" mass="30004" checksum="5E5BBAE32E9771A6" modified="2013-07-24" version="1">MEVTLLGTGDTIGTPAPGCDCDTCARAEELGVERTRFSVHVYNERTDESLLVDFSPDFRQQFLDNDVALPDAGIVTHVHFDHLDGLGNAYRLVRDMPVYAANETDPVTGESVAETARRRYDYLDTVTVRDATPFEPVESCGFEVTFVPVDHPPLVCYGLRIEDPETGAVFATTGDTSYGIPERSKAVLRGADLLLAEAIVPAESCEIHPKGGDHFDENGVPRTFGTKHMTRAGALSMADELDAATVRLVHCSHRFDPEEAFETPLAVDGERFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C7</accession>
    <name>R4W9C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446278.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07185"/>
    <dbReference type="EnsemblBacteria" id="AGN01384">
        <property type="protein sequence ID" value="AGN01384"/>
        <property type="gene ID" value="L593_07185"/>
    </dbReference>
    <dbReference type="GeneID" id="16182046"/>
    <dbReference type="KEGG" id="sali:L593_07185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1467"/>
    <dbReference type="eggNOG" id="arCOG02242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140786_1_0_2"/>
    <dbReference type="OrthoDB" id="101231at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="14135" checksum="937D217B46F9F5CB" modified="2013-07-24" version="1">MSEPDHDMRSLMEAADPSFDAVMTCVFGIQQHETRTYLTLLDHPGTTAEELADVLDRDRSNVNRSLTALLDKGLVKRDRRLLDPGGYVYQYTAVPLPDAKAMLHDALDAWTETVHGVIDEFEAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F9</accession>
    <name>R4W9F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07645"/>
    <dbReference type="EnsemblBacteria" id="AGN01474">
        <property type="protein sequence ID" value="AGN01474"/>
        <property type="gene ID" value="L593_07645"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07645"/>
    <dbReference type="eggNOG" id="arCOG03787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059309_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009269">
        <property type="term" value="P:response to desiccation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013990">
        <property type="entry name" value="WHy-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00769">
        <property type="entry name" value="WHy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="WHy" evidence="3">
        <location>
            <begin position="89"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="WHy" evidence="3">
        <location>
            <begin position="233"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="416" mass="43178" checksum="EADBEF67BCD4D29C" modified="2013-07-24" version="1">MSDNGSPGEGADAADDPLAGGGTGTDAGAASQAAGASSESALGAAAGTAKAALAPLVASKLRIFLLFLVATGGLLGGGFALGVLGAPAVNGVQNDFGNVTEDETTILTNVSVQNPNPIGLSLGGVTIDYQVSMNDVRVANGTKNGVSMGSGNSTMRLETTLYNDRIPPWFASHVRNDERTAVNIDATIDAYGFTRSISQQREIDTDILGSFSSTQDRPIDANQPLISDPVLVVEETDASWGTVSREETPIDMSFAMYNPNTQPIAISELRYNVTMNDVLVSQGATEDPFVIPGGTRNTLHATTAIQNQRLDEWWVSHLDESVYGHQVSQFRIDFTAVVELPTGETVVVPLDDLAYEDWITTDLFDEGGSVGVPPSEQSGDGSGSEGGNTSDDGTTDDGNTTDGSGGNDSDDGGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V1</accession>
    <name>R4W9V1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446738.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09495"/>
    <dbReference type="EnsemblBacteria" id="AGN01844">
        <property type="protein sequence ID" value="AGN01844"/>
        <property type="gene ID" value="L593_09495"/>
    </dbReference>
    <dbReference type="GeneID" id="16182650"/>
    <dbReference type="KEGG" id="sali:L593_09495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1955"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OrthoDB" id="83050at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="21942" checksum="68778482CF86D5C0" modified="2013-07-24" version="1">MHGEPEVTILRLGHRPGRDDRMTTHVALTARALGADRVLLPANATDAYDTATDVTGRFGGPFAVESTERTISILEEWEGSIAHLTMYGEPVQTVEEEVRTAHREEPLLVVVGAEKVPWDVYEHADWNLGVTNQPHSEVAALAVFLDRLFEGQELDREWDDAERAVVPKAEGKLVEELHAEDASTGSDGADSDGCDGASGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V7</accession>
    <name>R4W9V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446768.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09645"/>
    <dbReference type="EnsemblBacteria" id="AGN01874">
        <property type="protein sequence ID" value="AGN01874"/>
        <property type="gene ID" value="L593_09645"/>
    </dbReference>
    <dbReference type="GeneID" id="16182778"/>
    <dbReference type="KEGG" id="sali:L593_09645"/>
    <dbReference type="eggNOG" id="arCOG04741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954756_0_0_2"/>
    <dbReference type="OrthoDB" id="109207at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="13442" checksum="D9AF34F24BBDC331" modified="2013-07-24" version="1">MPLGFESGAWLFLAAGAFVLGHLVVLAYFLRGNAGRSEPALATPPDFTAEADPGRPTDAPPESVGSGRSKRSGSDELPPIERDQVVQCPHCGVENAAEFRYCRFCVGELTGGRTVADASSASRDGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA28</accession>
    <name>R4WA28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar nucleotidyltransferase ( glucose-1-phosphate thymidylyltransferase ) 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447123.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11420"/>
    <dbReference type="EnsemblBacteria" id="AGN02229">
        <property type="protein sequence ID" value="AGN02229"/>
        <property type="gene ID" value="L593_11420"/>
    </dbReference>
    <dbReference type="GeneID" id="16182100"/>
    <dbReference type="KEGG" id="sali:L593_11420"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2356"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="44391" checksum="89269FF4E3479A4A" modified="2013-07-24" version="1">MDAIVIAAGEGTRMRPLTDRRPKPLLPVGRTTLIQRIMDQCVDAVDRFVLVVGYRAEAIHETVGDDHRGVPVEYVVQSEPRGTAHAIGRASDLVDRRFLALNGDVLVDDGVVDDLAAAGGTAMAVREVPDPGNYGVVETSDDRVTGLVEKPRDPASNLINAGLYAFEPSIFDAIERIGASPRGEYELTDAIVRQVEAGHDVRAVEHGGTWLDVGRPWELLAATEHVLDDLGRARDASTLSGTQDPPDVKGAGDTHAVRQIDGTVEANVHVEGPIVVEEGARIRSGTYVEGPVVVRSGADVGPNAYLRGATVLGPGSRVGNAVEVKNSVLLPGATVGHLSYVGDSILGADVNFGAGTTVANLRHDDEPVRMTVKGERVSSGRRKLGVVVGDGAKTGIDTSLNAGVTLSTGARTGPNETVLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC3</accession>
    <name>R4WAC3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447598.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13825"/>
    <dbReference type="EnsemblBacteria" id="AGN02704">
        <property type="protein sequence ID" value="AGN02704"/>
        <property type="gene ID" value="L593_13825"/>
    </dbReference>
    <dbReference type="GeneID" id="16180864"/>
    <dbReference type="KEGG" id="sali:L593_13825"/>
    <dbReference type="eggNOG" id="arCOG03063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150429_0_0_2"/>
    <dbReference type="OrthoDB" id="105389at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15694" checksum="0CC27C3E98EB3D55" modified="2013-07-24" version="1">MADRSSDMTLAFSLEALQQLADPAVAIDDAREWSQYVGAVSAAPNGALSFTKERRIRLDFFSGTRPPAETLYAVKGNYRTERYVFVGVDGQRDLAESRHWEFQHVEDAADRAGWALTDVTENADDSGILGRLLARLGSALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS11</accession>
    <name>R4VS11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444889.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00200"/>
    <dbReference type="EnsemblBacteria" id="AGM99994">
        <property type="protein sequence ID" value="AGM99994"/>
        <property type="gene ID" value="L593_00200"/>
    </dbReference>
    <dbReference type="GeneID" id="16181191"/>
    <dbReference type="KEGG" id="sali:L593_00200"/>
    <dbReference type="eggNOG" id="arCOG04458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110565_0_0_2"/>
    <dbReference type="OrthoDB" id="89533at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007386">
        <property type="entry name" value="DUF447"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04289">
        <property type="entry name" value="DUF447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="24010" checksum="5B8409CBDDD8E258" modified="2013-07-24" version="1">MSHARSYGVTPDGERVEGWPARLAGVTETVIATKGPNDHWNQAALGISPTGGNDEEIPAGATTAATARSYGRTRTRRNLDAGRDAYVQFTTDPVDFVEAALTTFETDEPILERSAAWTRIECEERKRTVDRGTEIVTWTLEPVESGVRTRSVPTANRARAAVIEATVPASRLDVDGYDEADLLARLESLASVVDATGDARTLAAFDSIDEYVGWRDRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSJ9</accession>
    <name>R4VSJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445074.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01135"/>
    <dbReference type="EnsemblBacteria" id="AGN00180">
        <property type="protein sequence ID" value="AGN00180"/>
        <property type="gene ID" value="L593_01135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180328"/>
    <dbReference type="KEGG" id="sali:L593_01135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.231"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_2"/>
    <dbReference type="OrthoDB" id="28306at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="36173" checksum="DF15DBC31D489819" modified="2013-07-24" version="1">MEIGVLTVPLGDQDRREAFEYLADVGVDAVELGAGGWPGQDHLHRESLLEDADERQQLLDDAAEYDLTISALATHNNPLHPEEARANEADRELREAIELAGMLDVEAVTCFSGLPAGAPGDSTPNWITAPWPDEHAEAHEYQWEEVAIPYWEEIGEHAQEHDVKVAIEMHPNMLVYEPRGMLKLRDAANPWIGANFDPSHLYWQGIDVTEAIRLLGEEDAIHHFHAKDTKVYDANAREKGVLDTNAYTDEPNRSWMFRSIGYGHGEEHWKDVVSTLRMMGYEGALSIEHEDSLTSGREGLERAVDVLQRAVFETEPGDAYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSR8</accession>
    <name>R4VSR8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">L593_01335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445114.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01335"/>
    <dbReference type="EnsemblBacteria" id="AGN00220">
        <property type="protein sequence ID" value="AGN00220"/>
        <property type="gene ID" value="L593_01335"/>
    </dbReference>
    <dbReference type="GeneID" id="16182766"/>
    <dbReference type="KEGG" id="sali:L593_01335"/>
    <dbReference type="eggNOG" id="arCOG04063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_4_1_2"/>
    <dbReference type="OrthoDB" id="74155at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22792" checksum="69F9269C04DCB583" modified="2013-07-24" version="1">MPEVRRCSSHGFHEGDRCPVCGNVGEPVIDAERRRRLSKYLSGALRHFPDDAGIDLDERGWTARPGLVDAARRQYDWADDAAVAAVVATDPKGRFEVDDDRVRAAYGHSVPVELEPSDAPIPDVLYHGTAPDSVEAILSEGIRPMSRQLVHLSGSVAEAVEVGARHAADPEVLRVDAAGMVAKGHRITKRGNGVFTADRVPPEYVERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTM1</accession>
    <name>R4VTM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445479.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03170"/>
    <dbReference type="EnsemblBacteria" id="AGN00585">
        <property type="protein sequence ID" value="AGN00585"/>
        <property type="gene ID" value="L593_03170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182502"/>
    <dbReference type="KEGG" id="sali:L593_03170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.641"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054903_1_0_2"/>
    <dbReference type="OrthoDB" id="71077at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="31893" checksum="3B4430941EBDDFBD" modified="2013-07-24" version="1">MRFVEEIVVDDFLPTVRAMLAERLLEAGRTQREVAELLGISQSAVSKYAGGGVERTERIESDQRVRETVDELADGLASGEITRVQALIELEVLIRELEDGDLLAAMHEAVVPELSEHGGAFRVHDPDSELRTSERTLASLRRGLRTLESTSGFAGLLPNVGSNLVACVPGATTIDDVAAVPGRIVDVKGRATGSGDPEFGVSEHVAGVLLAAREAGSDARAAINVRYDPEIVATLESLGHETIEFPAEEPTDEAVGEVVASNPDATVAYQTGGFGVEPNVYVLGPDPESLAQTIREVCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUD4</accession>
    <name>R4VUD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04320"/>
    <dbReference type="EnsemblBacteria" id="AGN00815">
        <property type="protein sequence ID" value="AGN00815"/>
        <property type="gene ID" value="L593_04320"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.879"/>
    <dbReference type="eggNOG" id="arCOG05628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_5_5_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="27168" checksum="EB850EF9822330F6" modified="2013-07-24" version="1">MTTGLSALVILVASVVHGIAGFGFAQVSMGVMPLFRSASSASIIFTATAVVSNGRVWWSVRDAFDWRKWIVPVGGLVVGMPLGIYVFSAFSEVQLRVAIGAVLVLAVVIVGATQQLDVVTDWIEASDYRPGNLIGATAGMLAGILGGAVAVPGPPMIVYGAFMSASDFWTDEEMKATFTAFFGTLMLYRLGSLTYTGAVTTPLLVEAAIAVPMVFLGAWVGVYIFDTIPERIFQWVVLALLSVNAFVLLFTSVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUK2</accession>
    <name>R4VUK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445789.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04730"/>
    <dbReference type="EnsemblBacteria" id="AGN00895">
        <property type="protein sequence ID" value="AGN00895"/>
        <property type="gene ID" value="L593_04730"/>
    </dbReference>
    <dbReference type="GeneID" id="16181253"/>
    <dbReference type="KEGG" id="sali:L593_04730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.967"/>
    <dbReference type="eggNOG" id="arCOG05324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058621_1_0_2"/>
    <dbReference type="OrthoDB" id="28863at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="320" mass="35586" checksum="4E008783342D117B" modified="2013-07-24" version="1">MVELALVLPPEPDERWELAKQVGVDTAVVHALEIGDDSTAWNHDTLQGMQNWFENDGIEIGVIEGSVPVTDTTRLGLEGRDAEIAEFKQFLRDCGDLGIDTICYDWMAGIRWARTNVHVEARGGSLTSEYDAADMPGTSPHEAADVTHEELWENLEYFLEEVVPVAEEAGVKLGLHPDDPPREEVKGIPRIVNSVEAYDRVLDVVDSEYNGVTFCQGNFAAMGVDVPETIRHFGDRINFAHFRDVRGDEDAFVETWHDEGPTDMLAVMEAYDEVGFDGPIRPDHVPTMAGEDNSNPGYHTKGRLWAIGYMRGLLESVESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUW2</accession>
    <name>R4VUW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_00505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444950.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00505"/>
    <dbReference type="EnsemblBacteria" id="AGN00056">
        <property type="protein sequence ID" value="AGN00056"/>
        <property type="gene ID" value="L593_00505"/>
    </dbReference>
    <dbReference type="GeneID" id="16181735"/>
    <dbReference type="KEGG" id="sali:L593_00505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.103"/>
    <dbReference type="eggNOG" id="arCOG02841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_2"/>
    <dbReference type="OrthoDB" id="7900at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="40"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="383"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="436"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="670" mass="74554" checksum="4889A7EA70469068" modified="2013-07-24" version="1">MAAGSLPDEDDPFEEQRERVENPMKRLFLVYGRPNISYLVVGILSSIGARLLDLLPPILLGFAIDAIFRQDKSFAAIWLVPDAWIPASQEGQLWLTVGIIGGAFAVGALFHWTRNWGFNAFAQNIQHEIRTDTYDAMQRLDMDFFADKQTGELLSILSNDVNRLERFLNDGINSLFRLSVMVLGIAGVLFYFNWQLALVALLPVPLIALFTYIFIRTIQPKYKEVRSTVGAVNSRLENNLGGISVIKASTTESYESERVDEVSMDYFDANWDAIDTRIKFFPGLRVLAGIGFVTTFLVGGLWVLSEPGDAPWIFTEPISVGEFVTFILLTQRFIWPMAQFGQIINMYQRARASSARVFGLMDERGRVEESLDAKELEVSEGAVEYDDVSFSYGEPAADTADAGATDGDAVDDSTPEQILDSVDFEVEGGETVALVGPTGAGKSTVLKLLLRLYDVDQGAIRIDGTDVRNVTLPSLRRQLAYVQQDTYLFYGSVEDNIRYGSFDAPREEVVEAAKAAEAHEFIQNLPDGYDTEVGERGVKLSGGQRQRIAIARAVLKDPKILVLDEATSDVDTETEMLIQRSLDDLTAERTTFAIAHRLSTIKDADQILVFEGGQIVERGTHEDLLSRDGLYAHLWAVQAGEIDELPDSFVERAAERRARTEVEIESEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV40</accession>
    <name>R4VV40_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445999.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05780"/>
    <dbReference type="EnsemblBacteria" id="AGN01105">
        <property type="protein sequence ID" value="AGN01105"/>
        <property type="gene ID" value="L593_05780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181505"/>
    <dbReference type="KEGG" id="sali:L593_05780"/>
    <dbReference type="eggNOG" id="arCOG11314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730578_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="7750" checksum="97223F58A6DB3154" modified="2013-07-24" version="1">MSYPLVAGTVALIVAFVWGSITYVYRDAPRRGMDGDQWAGVLALTLGLGVFLYLYRRPALDDVEEPAVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV89</accession>
    <name>R4VV89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division ATPase MinD, archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446044.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06005"/>
    <dbReference type="EnsemblBacteria" id="AGN01150">
        <property type="protein sequence ID" value="AGN01150"/>
        <property type="gene ID" value="L593_06005"/>
    </dbReference>
    <dbReference type="GeneID" id="16181588"/>
    <dbReference type="KEGG" id="sali:L593_06005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1230"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OrthoDB" id="105856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010224">
        <property type="entry name" value="MinD_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01969">
        <property type="entry name" value="minD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="25449" checksum="1505637E24C95BA0" modified="2013-07-24" version="1">MTEQHVFAVASGKGGVGKTTTAVNVATAIAGGGYRVAVVDADLGMANMSGLLSLDPGDATLHDVLAGEAEVGEATYEVARGIFAIPSGEELDTYAKTDARGLGDVLDDLEGRFDYVFLDVGAGISHETVLPLGVADGVILVATPEPAAVNDVAKTRDLVERADGEVAGLVMTRTRATDAMDPEEVAADLGVDLLGTVPEDGAVRGSLYAGVPLVVQNPESKASIGYRRIAARLADRTGATQPKAATGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVC9</accession>
    <name>R4VVC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446079.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06180"/>
    <dbReference type="EnsemblBacteria" id="AGN01185">
        <property type="protein sequence ID" value="AGN01185"/>
        <property type="gene ID" value="L593_06180"/>
    </dbReference>
    <dbReference type="GeneID" id="16181650"/>
    <dbReference type="KEGG" id="sali:L593_06180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1262"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022247_0_0_2"/>
    <dbReference type="OrthoDB" id="30411at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="515" mass="59407" checksum="F12B3B3251C8C474" modified="2013-07-24" version="1">MSGTIDDVLVVGGGDIGLLTALGIQKQLPAVDVRVVDDFGTEVPQVGKSTYLDIQNILHGQLEIEEPEFIDEVKPIWKASVFFRDWCDTDAFHYPFDVSDTFKQPDTRNSSEHLVYYYDNLYDSDDHLTRCEQIVSQGKSPWYHEQNGDLSKYTKCAYHLNTARFNGYLRKLCRQRGVELVNDEITDVETTGSHVDAVHSGSDSYDADLFVDATGFNRILRSEQDEAEFRDFEFPLDSAFNVRIDRSLDDVIPATVVESGDYGWFWHIDTYDNRDLGYVFASEYVDDEDALEEFREYVDEVATADADPDPVGDVDDVDKYEFTSGYYERAWVDNCLAIGNAEGFVEPLQSTALTANASLAMQFAKLLSAHGRIADDDVRMAYNRAAERTWETIYDFIAVHYKYSYDDTEFWREMATREYSPRLDRIAEEFDRYGYDWQVERANEDGLQELSVFTVPDFYAMMRPLGASSVFYDTNDFTVSNDLVRELEQYYRRIRTQVQQQHLTVREFYEGVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVK2</accession>
    <name>R4VVK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06390"/>
    <dbReference type="EnsemblBacteria" id="AGN01225">
        <property type="protein sequence ID" value="AGN01225"/>
        <property type="gene ID" value="L593_06390"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1302"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080422_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="214" mass="22253" checksum="B695906E471E4C31" modified="2013-07-24" version="1">MATESDSLVDGIADAALAGVALLLTGGVSLLGIITAEALHPDYATTQEISDLGSTRPPDPVSYEPTATIFNATMLVSGALVLTAAFFLYRDGRRRALWLPLGVFGLGIFGVGVFPGDVTPWHGIFALLTFTSGGIAAALSARAVSKPFAYVCLLFGGFSLASLVYAIFLGDTGPLGDLELGGIERWVVYPLLVWVAGLGGYLLGERTDAADHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVM1</accession>
    <name>R4VVM1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_06490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446139.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06490"/>
    <dbReference type="EnsemblBacteria" id="AGN01245">
        <property type="protein sequence ID" value="AGN01245"/>
        <property type="gene ID" value="L593_06490"/>
    </dbReference>
    <dbReference type="GeneID" id="16181766"/>
    <dbReference type="KEGG" id="sali:L593_06490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1323"/>
    <dbReference type="eggNOG" id="arCOG00186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_2"/>
    <dbReference type="OrthoDB" id="6733at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="264"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="537" mass="59149" checksum="42986890A6493EDD" modified="2013-07-24" version="1">MSGSRPPAVRLEGISKHFGDVVANDDVNFDLERGSVHALIGENGAGKTTLMKILYGQYTPDAGRIYVDGEERSFESSRDAIDAGIGMIHQHFMLIDTLTVLQNVVLGNEPTDRFGRVDTERARREITEICEEYGFDVDEYLDDRIEDVGVGVQQRVEILKTLYRDADTIVLDEPTAVLTPQEVESLYQVMDELTAQGHSIIFITHKLEEAMRAADEITVLRDGHTVGTVDAEEATQEQLAELMVGREVLFEVEQHEHDVGAEVLDVAGLHVNDDRDIEKVSGLDFTIKEGEIFGIAGVEGNGQRELVEAITGLREASRGTVVYEEADISDLSRRERIEAGIAYVPEDRQEEGIVMNYDLVQNALLGNQTAEVFQNGRFLDWDEVERQAERIVEEYDVEPRNVATRSADLSGGNQQKFIVGREFEHDPTLIVAAHPTRGVDVGSIEFIHDRLLEIRDEGAAVLLVSSKLDEVQKLSDRIGVLYEGEFTDVVEPEAVNEQELGLMMAGQRPGQADADVPTSSSDDAAAGANAAAEGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW51</accession>
    <name>R4VW51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445390.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02725"/>
    <dbReference type="EnsemblBacteria" id="AGN00496">
        <property type="protein sequence ID" value="AGN00496"/>
        <property type="gene ID" value="L593_02725"/>
    </dbReference>
    <dbReference type="GeneID" id="16180268"/>
    <dbReference type="KEGG" id="sali:L593_02725"/>
    <dbReference type="eggNOG" id="arCOG06382">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709075_0_0_2"/>
    <dbReference type="OrthoDB" id="97456at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13533" checksum="45C3D904287AE490" modified="2013-07-24" version="1">MATTTHTETPGPELLEERSLLGIFVHLFALIPIALPIVAAVYVLSDHPYTVENARNALNWHLTILGLILVFFPLAFYVWDVFVIPAALVFLVGGTLSWIFGIVATAKAIFGTAWEYPLAPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW83</accession>
    <name>R4VW83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445425.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02900"/>
    <dbReference type="EnsemblBacteria" id="AGN00531">
        <property type="protein sequence ID" value="AGN00531"/>
        <property type="gene ID" value="L593_02900"/>
    </dbReference>
    <dbReference type="GeneID" id="16180371"/>
    <dbReference type="KEGG" id="sali:L593_02900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.586"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176006_0_0_2"/>
    <dbReference type="OrthoDB" id="129932at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="90" mass="10122" checksum="7FCE912AE9B1E400" modified="2013-07-24" version="1">MSASESTLPESDESTASWDDVRDLPPSAKLVAKVLEYNETLTQSQLADETLLPPRTVRYALNRLEEEGAVDSRFSFSDARKRLYTLAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWB5</accession>
    <name>R4VWB5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name evidence="5" type="ORF">L593_07875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446414.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07875"/>
    <dbReference type="EnsemblBacteria" id="AGN01520">
        <property type="protein sequence ID" value="AGN01520"/>
        <property type="gene ID" value="L593_07875"/>
    </dbReference>
    <dbReference type="GeneID" id="16182218"/>
    <dbReference type="KEGG" id="sali:L593_07875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1613"/>
    <dbReference type="eggNOG" id="arCOG01748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_2"/>
    <dbReference type="OrthoDB" id="51806at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="4">
        <location>
            <begin position="382"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="520" mass="54409" checksum="25726D67C8822CB9" modified="2013-07-24" version="1">MSEDDATTDEQADADSDGADSGEGVVRRDRFAGGPAREFMSSLDADRRIFEADLAVDRAHTLMLAEQEIIEEDTAGEILAALDDIEEAVESEGYGAVLSEGEDVHEAIETAVIERVGPEGGRMHTARSRNDEVATCIRYRLREDVIAVLEAVAETREVLVEAAEEHSETLLPGYTHLQPAQPITVGFWLASYEAALARDASRLLDAFTRINESPLGAAAFAGTTFDVDRQHAAALLGFDGIVENAMDAVSTRDFLLETAGALSGLSVTLSGIAEDLVVYSNRGFVDLDDDYASTSSIMPQKKNPDSLELVRAVAGDAAGAHQALATTLTGLPRSYNRDLQRAGPHVWNVIDDVADAVDVAGGAIATAEWNEETCAAAAGEGFSTATGVADLLAQSGVPFRTAHEVVAVAAEDVAALEDDQTAGGAADPDAAIDVLDDAAHAVLGESITDAVEESALRSALDPTESVASRDSAGGPAPSAVEDAIESAKASLEDDLIAIVATRKGLEGAQERLESGVSEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWC3</accession>
    <name>R4VWC3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ORF">L593_07925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446424.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07925"/>
    <dbReference type="EnsemblBacteria" id="AGN01530">
        <property type="protein sequence ID" value="AGN01530"/>
        <property type="gene ID" value="L593_07925"/>
    </dbReference>
    <dbReference type="GeneID" id="16182254"/>
    <dbReference type="KEGG" id="sali:L593_07925"/>
    <dbReference type="eggNOG" id="arCOG04175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177460_1_0_2"/>
    <dbReference type="OrthoDB" id="125208at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6646" checksum="66204A209C71356D" modified="2013-07-24" version="1">MSVYTVSGRFQIREGWQAFETEIEAANEDVAEEHTYSEMGSRHNLKRAQVEVEEVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWF7</accession>
    <name>R4VWF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446469.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01575">
        <property type="protein sequence ID" value="AGN01575"/>
        <property type="gene ID" value="L593_08150"/>
    </dbReference>
    <dbReference type="GeneID" id="16182316"/>
    <dbReference type="KEGG" id="sali:L593_08150"/>
    <dbReference type="eggNOG" id="arCOG07497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170795_0_1_2"/>
    <dbReference type="OrthoDB" id="130338at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="9751" checksum="2270886FE3764CE7" modified="2013-07-24" version="1">MSSPPSHLELPSDGADASFDERARSVLQTARRHVFTPVRAAGFWSAIALPFLYVPLVATGLETEAELSVFLALLAANVVAIALGHSHSPGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWS6</accession>
    <name>R4VWS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00701">
        <property type="protein sequence ID" value="AGN00701"/>
        <property type="gene ID" value="L593_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03750"/>
    <dbReference type="HOGENOM" id="CLU_1821097_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15386" checksum="232672BAD69EC4FF" modified="2013-07-24" version="1">MDRLADGTRLLLGLTYLGGAMVHLLFWATDRSVYADITQYVQFDWYRTVWTDLVLPNLGVLLPLLAAFELAVGVAICLAGRRARLGLAAGAAFNLVVAPLGFWWPSNVALAALHGLLLRREFPDSVIGGLALHQGRRSRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWV0</accession>
    <name>R4VWV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445620.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03875"/>
    <dbReference type="EnsemblBacteria" id="AGN00726">
        <property type="protein sequence ID" value="AGN00726"/>
        <property type="gene ID" value="L593_03875"/>
    </dbReference>
    <dbReference type="GeneID" id="16180699"/>
    <dbReference type="KEGG" id="sali:L593_03875"/>
    <dbReference type="eggNOG" id="arCOG02764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_5_3_2"/>
    <dbReference type="OrthoDB" id="123956at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="6896" checksum="0D407176A8414B2F" modified="2013-07-24" version="1">MSTEITVEGMTCEGCEEVVEEALEMADGVESAEADRYEDTATVEGDADVEVLVDKVEMAGYEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXE4</accession>
    <name>R4VXE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446809.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09850"/>
    <dbReference type="EnsemblBacteria" id="AGN01915">
        <property type="protein sequence ID" value="AGN01915"/>
        <property type="gene ID" value="L593_09850"/>
    </dbReference>
    <dbReference type="GeneID" id="16182832"/>
    <dbReference type="KEGG" id="sali:L593_09850"/>
    <dbReference type="eggNOG" id="arCOG10124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_2_2"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="4">
        <location>
            <begin position="112"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="42653" checksum="726233603D0E8030" modified="2013-07-24" version="1">MTDGDDDPESSALETDDQPPLAAIVSKDRSQAALGALREADLYDDTRRIREFDDGTIAIPVTAAPLPDRQVTLGIHEIVRQEDPEPRAGGLEALLRERGWTDAEIETAPGSWAVIGTVVIVEIPDDCADEAAVGEALLDLHREADTVLAREGIDGQTRDPTQRVVAGAGDTETIHAEHGVRYALDLAEVMFSPGNEAERARIAALVAAGRDAGAEGPVATLGEESGVDPVPDAVTGLDPADGEPLEAVGGPAEHVFDMFAGVGYFTLPAAVAGAEVTAAEIDPDTFQYLIENAQLNDVGDRVSAYLSDCREVAEFVDADRVLMGHWDAAEYLDAAFDAVRDDGVIHYHAVVAEPELPDDPREDLEAAAADAGRSIAIVDLRRIKSYGEGVWHVVVDARVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXG4</accession>
    <name>R4VXG4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="4" type="ORF">L593_09975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09975"/>
    <dbReference type="EnsemblBacteria" id="AGN01940">
        <property type="protein sequence ID" value="AGN01940"/>
        <property type="gene ID" value="L593_09975"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2055"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_6_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
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    </evidence>
    <sequence length="317" mass="36241" checksum="D7D7A10744E23FC1" modified="2013-07-24" version="1">MVPVIEWLRTRLQRAYERQLERAIDDPPEHVAVIQDGNRRYARERGDEATDGHREGAKTTQAVLEWCEQLGVEELTLYAFSTENFDRPQEQLDVIFDLAEEKLYEFADAEEIHENEVSIRAIGDLPRLPERVRDAIDYAERRTADYDQFVLNVALAYGGRERLLSATRDVVAEAAEGDLDPEEIDVDTVADRLYDRRVRDVDLIVRTGGVQRTSNFLPWHANGNEAAVYFCAPYWPEFSRADFLRGLRTYEHREESWRRTRARRGIALLRALGGVELAEARETVRRCRDALPAAERPAPETDATDVADPADPSPSGE</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="147" mass="14895" checksum="08788ECCB7909983" modified="2013-07-24" version="1">MFEAPDRNGLALAAGDHLAVIAIVGWGIVDHHGLEGLTDLQEVVETIGPFLVGIAVATVLVGTYEPAHTATAAAQLRSVAAAAIGAVGVGLVIRTSPAIEGGAAWPFGLVMLGTITLGLLFWRSAAITVTRYRSGAAESAGREPAGE</sequence>
</entry>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="510" mass="58413" checksum="EAFA3A93EC69BCD3" modified="2013-07-24" version="1">MHKTPQVNEVNEFIEIASDFEDPLEVIREALSNSYDAKATQVDIKIEQDDEGRNTLIIEDDGHGMDEDNLSSFFDLGNSNKDDAIGYKGHGTKIYYKSDKIQVETVKDGTQIESVMDQPWAKLNNRELPTYSVDRRDVDEPSRTRIEVHGFQAGQGFDPQQLTYNKIEHYIRWKTIGGSTAWHFSNDFHAMEINVELSPTIDDTRQPIETDNRLKFPAENVDPDGEFVAEAMCKHYPPRELTVSLDDGRELTIEIVGMVGGKEARNKLPTYGKHSAQFGIWLAKDHIKVERYNDAIGADNEFFHFFFIANCQELELSANREKIRNKSGDVYQAITDELDRYMTKVCQETWYRDYIERRKLEDKKRSIQSQESSLEERLERTRGADGLSPSNPAEVIALLERYSANGAPESLQIADFQMNDEVNAILDTANGYEHASVQVKLSDFFEEETPLSNIDRFVCWKLGDLDALTRIERTSYLGEPIRFDFQKGEIQYGSEEPELIPVLELDGKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYA0</accession>
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        <submittedName>
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    <organism evidence="11 12">
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            <taxon>Natrialbales</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <name>Mg(2+)</name>
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        </cofactor>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
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        <property type="protein sequence ID" value="AGN02230.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_11425"/>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="entry name" value="GlmM_arc-type"/>
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        <property type="entry name" value="PGM_PMM_III"/>
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        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="153"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="248"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="368"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="46611" checksum="DFDF0B306D885EDF" modified="2013-07-24" version="1">MFGTSGVRGRFGEDVTADLALSIGRALATHGTERIVVGRDPRLTGSLLADAVSAGAREYGADVVRIGVAATPTIARSVGWYDADAGVAVTASHNPPEDNGLKLWTDEGMAFGEDRRRRIAEIVEEGAGEPVAWDETGSETKRTDATDRHREALTDAVTIEEPLSVVVDVGNGAGGVTVGALRDLGCSVTTLGGQPDGRFPSRPSEPTGATCETLAAHVAGTDADLGIAHDGDADRTMAVDERGRFLAGDELLALFAGEAVADGARVVAPVGASLVVDDVVEREGGRVERSRVGDVYVAERASEPGVSFGGEPSGAWIWPKQTLAPDGPLAACRLAALVARERPLSQQVAGLPAYPVERDQIEVDPTAKERIVDAVARRANERYDEIDERDGVRVETDSGWFLVRASGTQPLVRMTAQGRTEDRTVELTETARELITEALQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYR4</accession>
    <name>R4VYR4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446275.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07170"/>
    <dbReference type="EnsemblBacteria" id="AGN01381">
        <property type="protein sequence ID" value="AGN01381"/>
        <property type="gene ID" value="L593_07170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182026"/>
    <dbReference type="KEGG" id="sali:L593_07170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1464"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_2"/>
    <dbReference type="OrthoDB" id="24697at2157"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="453"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="529" mass="55916" checksum="3E90B63301997C9F" modified="2013-07-24" version="1">MKVLVTDPIADEGIAKLREAGHEVETAYDVEGDALLEAIADANALIVRSGTDVDEAVFDAAEELIIVGRAGIGVDNIDIDAATDHGVIVANAPDPNVRATAEHTVGMIFAAARSIPQAHSRLQDGEWAKSEYLGTELNGKTLGVVGLGRVGQQVAKKLDSLGMDVVAFDPYISAERAEQIGAELYEDLQDALAETDVATVHTPLTPDTEGLLGEEEFAQLEDGYVINCARGGILDEDALAAAVGDGVMAGAALDVYESEPLAEDSPLLDVDEIVTTPHLGASTAAAQTGVATLTADQVLAAFEGEPVLNALNAPSVDESAFPRIEPYIDLADTAGKIAAQLFDGRVESVEVRYEGDIAEEDVDLVTASALKGVFEPLEWQVNAVNAPQVAEDRGVDVTESKSHQTEDFQSVVRVTVANNGDEISVDGTLFAGDDPRIVRIDGYRVDAIPYGTMLVARNRDEPGVIGLIGTTLGQHDVNIAGMFNARETIGGEALTVYNLDDPVPDEVAEELHADDRITDVREITLDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYW9</accession>
    <name>R4VYW9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="8" type="ORF">L593_07480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446335.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07480"/>
    <dbReference type="EnsemblBacteria" id="AGN01441">
        <property type="protein sequence ID" value="AGN01441"/>
        <property type="gene ID" value="L593_07480"/>
    </dbReference>
    <dbReference type="GeneID" id="16182196"/>
    <dbReference type="KEGG" id="sali:L593_07480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1528"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OrthoDB" id="17629at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="433" mass="46112" checksum="3E89C3A2B9B1ED40" modified="2013-07-24" version="1">MTAYPPIREQLAESGDDPAPDEAVESGERKLEWARQHMPILAELREDVRANQPFAGQTIGMAMHVEASTGVLVELLALGGAEVAVTGCNPLSTHDDVSAALDAIDGISSYARRGVDDEEYYAAIEAVLAHEPTITVDDGMDMVAAVHEDYPELIETIVGGAEETTTGVHRLRAMADDGALDYPVFAVNDTPMKRLFDNVHGTGESSLANIAMTTNLSFAGKTVVVAGYGYCGKGVAKKAAGQNADVIVTEVEPRRALEAHMEGYDVMPMAEAAAEGDVFVTATGNRDVITAESFEAMDDGVVLANAGHFDVEIDLEGLEDMAVDTYEARDGVQAYEMADGRRINVLAEGRLVNLAAPNAQGHPIEVMDQSFGIQAVVVRELVENGDSYDAGVHDVPDELDEEVAEIKLAAEGVELDAISEAQADYMGSWDHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYY5</accession>
    <name>R4VYY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446350.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07555"/>
    <dbReference type="EnsemblBacteria" id="AGN01456">
        <property type="protein sequence ID" value="AGN01456"/>
        <property type="gene ID" value="L593_07555"/>
    </dbReference>
    <dbReference type="GeneID" id="16182146"/>
    <dbReference type="KEGG" id="sali:L593_07555"/>
    <dbReference type="eggNOG" id="arCOG02646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="22678" checksum="B539B225CC2F82D9" modified="2013-07-24" version="1">MSDDRSTREELLDAAYEVLVSPEYEGFTTAAVAEAAGRNQSLVHYYFDTKRDLVLALFDYLHEIADEHLAAAADAEDPADRLEALLTYLVWADPDATDGEDTLEDAIAFKRGLLWLEAQALTDEDLRAAMDADRRYFWDAVESTIREGIERGRFRASIDPEATAALLVAAVGGAQTWAAIYGEEARDQLVVEAMETLIQEWLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ31</accession>
    <name>R4VZ31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">surE</name>
        <name evidence="6" type="ORF">L593_12930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447419.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12930"/>
    <dbReference type="EnsemblBacteria" id="AGN02525">
        <property type="protein sequence ID" value="AGN02525"/>
        <property type="gene ID" value="L593_12930"/>
    </dbReference>
    <dbReference type="GeneID" id="16182554"/>
    <dbReference type="KEGG" id="sali:L593_12930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2651"/>
    <dbReference type="eggNOG" id="arCOG02303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_2"/>
    <dbReference type="OrthoDB" id="110625at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="5">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="273" mass="28646" checksum="AFF51894594294AA" modified="2013-07-24" version="1">MNETPEVLLTNDDGIDAAGIQVLEAGLGEIANVTVVAPATDQSAVGRQTSTDVVIEERNGGVALTGTPTDCVIAGLQEFCPDPDLVVAGCNRGANLGGYVLGRSGTVSAAVEAAFHGVPAIAASLYVPVDDTAFEDAEVEERHYREAVRATKFLVEHAIPAGVFDHADYLNVNAPVPSGYLAVTDDSADGPAPMRITTPSHRYEMDAVRDGDQVRLEDRIWQLMADGDLEEEPGTDRHAILDGAVSVSPLTAPHTTEHHEALDGLAAAYPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZU0</accession>
    <name>R4VZU0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446625.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01731">
        <property type="protein sequence ID" value="AGN01731"/>
        <property type="gene ID" value="L593_08930"/>
    </dbReference>
    <dbReference type="GeneID" id="16182750"/>
    <dbReference type="KEGG" id="sali:L593_08930"/>
    <dbReference type="eggNOG" id="arCOG08120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163109_0_0_2"/>
    <dbReference type="OrthoDB" id="123845at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11502" checksum="A2C3377271A1BDB8" modified="2013-07-24" version="1">MATTQAPDEEAYADGTPIVELLGDSARVKLLSVFAGKRSREFTISELAENAGISRKSVYNHVDELVEFGVAQPIEAGSGTRYRTAETAVAQKLFELDGVTLQRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W001</accession>
    <name>R4W001_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447729.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14480"/>
    <dbReference type="EnsemblBacteria" id="AGN02835">
        <property type="protein sequence ID" value="AGN02835"/>
        <property type="gene ID" value="L593_14480"/>
    </dbReference>
    <dbReference type="GeneID" id="16181278"/>
    <dbReference type="KEGG" id="sali:L593_14480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2961"/>
    <dbReference type="eggNOG" id="arCOG02365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02385">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="258"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="468" mass="52523" checksum="7E0A66E75E216595" modified="2013-07-24" version="1">MEHALESVLLEYSQDKVIVVDEDGRLRYANEAAERILGYDPDVLVGTNAFDLVHPADLEETREIFDSVIEAPEPTTETHRYRVRAADDSIVWLESRFSNVTDDAIGGYVISSRDVTEQIETERERKAAEDRLTEIAGTVGDVLWMFDDDWTELLFVNPAYEDVYGAPTETVMNDPSTFLKAIHPEDRDRVRAAMERMSDGESVEIEYRVNREREYDRWVWVQGEPILKHGDVVRIVGFARDVTDRRRRERQLAVMDNLLRHNLRNDMSVIVGNAEMISTEGDDTSAERAEIIRTQGRELVESAEKQREIIELLTTPAVPTALDLAETVAAGTELVAKRHPGVTVDADVPAGLAVEALGELRLAFAELVENAIEHVPNDDPTISVTAERTDDDVVVVVTDECPPIPEVEYRVLTGDWIMDDVYHTSGLGLWLVYWVVDLSDGEIEFSQCDSGGNTIQIQLPTAAPESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W085</accession>
    <name>R4W085_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_09755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01896">
        <property type="protein sequence ID" value="AGN01896"/>
        <property type="gene ID" value="L593_09755"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09755"/>
    <dbReference type="eggNOG" id="arCOG07838">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447340_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="PTHR13572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="610" mass="67470" checksum="BFE8F0C36B2C3C0E" modified="2013-07-24" version="1">MMDTVSTRMDKELPRRVFLTTTVPLGGTLLAGCNQPTDTEEETQTENTTQTDTQTDQPSETPDPLANADFTLSETGIIYGDSVVVGLELENTSEAELNRTLPLTVGGQQLDRAQLTLAPGESTTVELTGTPEKTGTQTVEVGNHHVGTVVVRAAKPDAARAVGAHYYPWYGSPLHDWRDGEWSRESPSTPVLGDYNSADPAVIEQHIDWCRQAGVSWLNVSWWGPNSVHDTRFQEDILGHPRADELSWSILYETTGRLGSDPVALDDDYALERFTNDLQHLAETFFNRDSYKRIDGRPVLYIWVAQNLRGDVESAYQSAVEAAGVEPYLIVDMPVRTSLAGQPMIEVADAVTTYSVYNPNEPTREAFIERAQSTYRSWYRAADYLDVDVIPTAAPGFDDTEITHTQRDNEPVPSMPEIYQQTGQSARHYADGPVLVTSFNEWYEDTQIEPSEQHGTAYLDATAEIIASAEREPPTFEGEVFRLIFERTVPESELNPQVEDGRDLTFMLYQLTIETDTGATVLDADIGTRPEGVEFIVGSSGPEQADSNSWQWLGGSRETVISVPSLPDRGRIDLTGIGATDMAVSLKVGHERLDTTRITDELATQTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W095</accession>
    <name>R4W095_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447829.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15005"/>
    <dbReference type="EnsemblBacteria" id="AGN02935">
        <property type="protein sequence ID" value="AGN02935"/>
        <property type="gene ID" value="L593_15005"/>
    </dbReference>
    <dbReference type="GeneID" id="16180966"/>
    <dbReference type="KEGG" id="sali:L593_15005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3064"/>
    <dbReference type="eggNOG" id="arCOG04511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043006_0_0_2"/>
    <dbReference type="OrthoDB" id="69099at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="349" mass="37177" checksum="8CCB6C331155EE70" modified="2013-07-24" version="1">MNRRSVLRGVGAGLSAAVAGCFGYFETESVWSGAPLVEDRPDAVYLPASVEEMASYGTRDLADGSRCSLHFTFPHRFWTVTGSTKTRVEVAESDSMHLMVSVWDPVTGVVLPRQPAGTLLSDGDPVESYQLWSMLAQRMGYHFGNNVSLPGEGEYEVRVDFDPIGVRTAGAFAGRYQQAESASFQIDFDSSDVLDLSIDEIPADRRGTRAATEPMTGMGPPPGQVPPASDLPGTPLGTGSSADASIVGRLLDEPPAGIEGTGEYLAVSMRTPYNRIALASSSLAARIDGSSVDLVETIDDGLGHHYGVVLSDSLQSAPTIEVATPPQLARHDGYETAFFDMPSVDLEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0I4</accession>
    <name>R4W0I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446925.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10430"/>
    <dbReference type="EnsemblBacteria" id="AGN02031">
        <property type="protein sequence ID" value="AGN02031"/>
        <property type="gene ID" value="L593_10430"/>
    </dbReference>
    <dbReference type="GeneID" id="16181752"/>
    <dbReference type="KEGG" id="sali:L593_10430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2150"/>
    <dbReference type="eggNOG" id="arCOG00505">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061385_1_0_2"/>
    <dbReference type="OrthoDB" id="50620at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="32440" checksum="2C21D2CCA9B005D2" modified="2013-07-24" version="1">MEPGDVAAVELGDCAGISYVDTGMYDVAGYGSVYVIDAPEPAVVDTGIGADYEHVQAAIEAAGIGEEDLAAIAVTHVHLDHAGGAGRLARDYPNATVYVHEIGATHLVDPERLVEGTKRAVGDQWQYYADPVPIPEDRIETLTDGDRIDLGDRELVAHHAPGHAPHQVVYHSPSDDAVFTADAAGIYVPERDAVEPTSPPPNFDPEQALADVETIRDLDPSVLCYAHFGPARTADHLAAYETVLADWVDAVAAAREELGGEDASDEAVVDRLLASVDTDELWGEEKAMAETAMNVRGVLVALDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W158</accession>
    <name>R4W158_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447190.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11765"/>
    <dbReference type="EnsemblBacteria" id="AGN02296">
        <property type="protein sequence ID" value="AGN02296"/>
        <property type="gene ID" value="L593_11765"/>
    </dbReference>
    <dbReference type="GeneID" id="16181149"/>
    <dbReference type="KEGG" id="sali:L593_11765"/>
    <dbReference type="eggNOG" id="arCOG02996">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090569_2_0_2"/>
    <dbReference type="OrthoDB" id="117129at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="10830" checksum="5825E47280C10F2D" modified="2013-07-24" version="1">MERIDTTAQTGFFDVVAGTDRSQAATMTLEPGQSTGGPSNRHAESDQWLFVVEGSGEATIDGDTHDLQAGTLVLIEPGEPHEITATGDQPLVTINVYAPPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1T3</accession>
    <name>R4W1T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_13385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447510.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13385"/>
    <dbReference type="EnsemblBacteria" id="AGN02616">
        <property type="protein sequence ID" value="AGN02616"/>
        <property type="gene ID" value="L593_13385"/>
    </dbReference>
    <dbReference type="GeneID" id="16180583"/>
    <dbReference type="KEGG" id="sali:L593_13385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2738"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OrthoDB" id="40988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="200"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="46971" checksum="CE40921107CA422B" modified="2013-07-24" version="1">MSSDQSAVPADSTADDADTASESARATARKQLERAAAELDLDRNVVERLRHPAKVHEVTLPVERDDGSVDVFTGYRAQHDSVRGPYKGGLRYSPHVTKEECVGLSMWMTWKCALMDLPFGGAKGGIQVNPKALSDDEKERLTRRFAHELRTAIGPMQDIPAPDMGTDAQTMAWIMDAYSMENGETEPGVVTGKPKVIGGSPGRSAAPGRSVAIITREALRYYDTPLEGARIAVQGYGSVGGHAARLLDDWGATIVAISDVEGAIHDPTGLSVDEIPLHDEQPGAVTAHEGSSVSHLTNDDLLELDVDVLIPAAIGNVLTETNANAVQADLIVEGANGPTTSAADAIFRERGLPVIPDILANAGGVTVSYFEWLQDINRRSWSLERVNEELETEMVGTWNRVREEVAERDVSWRTGAYVVALSRVAEAHSHRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2L5</accession>
    <name>R4W2L5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444916.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00335"/>
    <dbReference type="EnsemblBacteria" id="AGN00022">
        <property type="protein sequence ID" value="AGN00022"/>
        <property type="gene ID" value="L593_00335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181929"/>
    <dbReference type="KEGG" id="sali:L593_00335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.67"/>
    <dbReference type="eggNOG" id="arCOG01585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_4_0_2"/>
    <dbReference type="OrthoDB" id="81422at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="21636" checksum="32526534F9AD66DD" modified="2013-07-24" version="1">MHQLDDTDLEILEMLGEDARRPFSEIADRVGMSGPGVSDRVDRLRDAGIIERFTVDVDRTQLRDGVPVFVQVRGHAGSVQELKDDLASEDPVEHVFVTAAGECWFVARPPEGSVRQWLDDRIDRDEASVTVTLLDEVAWTPSIGGTAFALACAECGNTVDSEGEQATIDGERYSFCCTSCRDRFLERRDRIAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2S2</accession>
    <name>R4W2S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445011.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00810"/>
    <dbReference type="EnsemblBacteria" id="AGN00117">
        <property type="protein sequence ID" value="AGN00117"/>
        <property type="gene ID" value="L593_00810"/>
    </dbReference>
    <dbReference type="GeneID" id="16182774"/>
    <dbReference type="KEGG" id="sali:L593_00810"/>
    <dbReference type="eggNOG" id="arCOG00702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_6_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="134"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="486" mass="49711" checksum="C07E240CB0A6BE55" modified="2013-07-24" version="1">MVSRRTLLELGGSAIGLSFLGTVTASAGDAQYLVRGSGGVARRVESSGFDIRYELADGAVLVVVGPEDAESELRSVAGVVDAVRDASFEVELPGPVESVGASVDGHESLDGILTENQWDKHRTNVAAAHELATGEGTTIAVLDTGVDHEHPDLAANVDESASRLFASLDSLQDNPWDVNGHGTHVAGIAAANGSVGVTGTAPDADVVSLRVFYLVETDDGPVLTTTTGDILAAIDYAASIGADAANLSIGTPPIPPSGNSEGYRPMYQTVIQHATRAGTLVVVSAGNASANLQQGGYFTVPNSVASAMSISATGPADGLSYYSNYGTNEIDVGAPGGLYSSLATSFCAIQEWLAAAEEGEEPPSLISNDPREAGETGTLWLDEDGVPTSDPDAIASTTECPIPEWPYPFNFVFSTLPGGEWGWIAGTSMAAPQVTGAAAVLRDANPGASPAQLEQAIEQSADGTDGKNDPSLGAGRLDVAGALEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Z3</accession>
    <name>R4W2Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445111.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01320"/>
    <dbReference type="EnsemblBacteria" id="AGN00217">
        <property type="protein sequence ID" value="AGN00217"/>
        <property type="gene ID" value="L593_01320"/>
    </dbReference>
    <dbReference type="GeneID" id="16181802"/>
    <dbReference type="KEGG" id="sali:L593_01320"/>
    <dbReference type="eggNOG" id="arCOG05313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493018_0_0_2"/>
    <dbReference type="OrthoDB" id="77015at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="PTHR31977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="DUF1917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="21033" checksum="89712793B45EC961" modified="2013-07-24" version="1">MDLETDPTEITEDGRYWLRAQRVTGYPRIARDTYFPKHGVQRPADVTEADLPETDDEAVAELDREALAEGYVSGKWQVMAPEEDVPALWADVLDDIEKEVIWDAKVATARGYEELPYDEYVITVYTPNYFETHDVERVRARLREEHGVARALSYKPDIYTSKGMVDENADEWGLERAARFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W318</accession>
    <name>R4W318_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_01520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445151.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01520"/>
    <dbReference type="EnsemblBacteria" id="AGN00257">
        <property type="protein sequence ID" value="AGN00257"/>
        <property type="gene ID" value="L593_01520"/>
    </dbReference>
    <dbReference type="GeneID" id="16179849"/>
    <dbReference type="KEGG" id="sali:L593_01520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.309"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OrthoDB" id="40988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="183"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="418" mass="45347" checksum="02AAB1941C1A4104" modified="2013-07-24" version="1">MSDDVNPFESLQEQIDDAAAHLDVSDGLITRLKNPERILETNLTVELDDGSLDTLRAYRSEFNGDRGPYKGGIRYHPGVDRDEVKALSGWMVYKCATVGIPYGGGKGGISIDPSDYSEEELERITRAFAVELRPLIGEDKDIPAPDVNTGQREMNWIKDTYETLENTTEPGVITGKDIDSGGSEGRVEATGRSTVLAAREAFEYLGRDIADATVAVQGYGNAGWITAKLADEMGATVVSVSDSSGGIYDEDGIDPVAAKDHKRETGSVVGFHGATEEISNDDLLTLDVDLLVPAALENAIDADLAEDVSADVISEAANGPLTPDADDVLVDEDVLVVPDILANAGGVTVSYFEWVQNRQRFYWSEEKVNDELETIIVDAFDDLVEAYETHDLPNFRTAAYVVAIQRVVDAYDQAGTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W369</accession>
    <name>R4W369_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01980"/>
    <dbReference type="EnsemblBacteria" id="AGN00347">
        <property type="protein sequence ID" value="AGN00347"/>
        <property type="gene ID" value="L593_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.402"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="356" mass="37940" checksum="D4F490842F94D87A" modified="2013-07-24" version="1">MSNASSRGGDRSGNPPAIAVEGLDVTYADGTRAVRDVDMIVPEGEFFGFLGPNGAGKTTTIKVLATLLSPTGGHVEVNGFDVTAEPRKVRESIGYMAQEVSVDPELTAAENIRFAAESYGVPRVDRADRVEDLLDLVDLADDADKRAEEFSGGMKKRLDAATALVHRPPLVFLDEPTTGLDPKARQRLWEYFRRINGQGTTIFLTTQYLEEADQLCDELAVILDGSIVAEGSPADLKREVGGEVLDVEIESAGNAFESDGAAIERAAEIARSFEAFEQATVTESADGISVTAETARQHGTDLLVALRDAGVTVTGFNLHAPTLDDVFLAITGESVDVETLEGGRTGPEAPTEEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3D6</accession>
    <name>R4W3D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445361.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02580"/>
    <dbReference type="EnsemblBacteria" id="AGN00467">
        <property type="protein sequence ID" value="AGN00467"/>
        <property type="gene ID" value="L593_02580"/>
    </dbReference>
    <dbReference type="GeneID" id="16180434"/>
    <dbReference type="KEGG" id="sali:L593_02580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.523"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003088_0_0_2"/>
    <dbReference type="OrthoDB" id="5636at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="280"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="676"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="863" mass="92951" checksum="A30B8B4BDC23D168" modified="2013-07-24" version="1">MDRVERFTKLVSRHSKWLIVGILLLTVVMAGGMGQVSQESDLNQFSFGSDAEQAQDYVDANFTAADENTTNVQIIFREDGGDVLTKESLVREIELQQELLEDEEIRSTLADQSFRGLSNVVAQTAIAQQRNQTVGPGGVDATLEEQRQALASMNEEEIDAMLAGLLGENGGQSAAFAFVPRDFEAGSTSADARAMFVTQRTTADTGPEGQTPENITDSQLRMDEIVDDRYGDNAFTFGSGIVNDEINRSMSDSMAIVLPLALLFVVLVLTIAYRDLLDILLGVSGIFLVLIWTFGFMGWTGITFNQIMIAVPVLLVGLSIDYAIHVFMRHREQRNDPDEAGPDTATDTRGAMEVVLMGLGAALLWVTITAMIGFLSNLVSPLPPIQDFGLASAFGIASTLLIYGTFVPALKVEIDEFLEGRGWDRRKQAFGTGGGRFSEVLAGGKTLARRTPWAVVAFALLLTVGGVYGATQVDTSFQQEDFLADDPPGWMDSLPEPFAPGEYQIKQQLDFVDERFSRDQQTEILIRGDVTDPATLERMAAVQEDAAQRDSLVTLPNGRAAVESPLTGMQALADANEQFNASFTAADTDGDGVPERNLRQLYDAYYAAAPGEAAGTLQLTEDGEYAAARMTFTVSGEETTSTTASDTRDLADTFEGSPATATATGQIVVFDVIEQELFSTVIQTLIVTFIAVFAFLMLAYRFVHGSALLGAVTLLPILLTVTWILGSMYLLGVPFNVITGTITSLTIGLGVAYNIHISERYQLEIDRGQDAWTAMHRAVTGTGGALLGSAGTTIGGFGVLAFAILPALQQFGIITGLTIAYAFLGSVFVLPSFLVLWTRYLGPSETLERDAAPSGNTAAPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3K1</accession>
    <name>R4W3K1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445471.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03130"/>
    <dbReference type="EnsemblBacteria" id="AGN00577">
        <property type="protein sequence ID" value="AGN00577"/>
        <property type="gene ID" value="L593_03130"/>
    </dbReference>
    <dbReference type="GeneID" id="16180440"/>
    <dbReference type="KEGG" id="sali:L593_03130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.633"/>
    <dbReference type="eggNOG" id="arCOG02046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_2"/>
    <dbReference type="OrthoDB" id="18569at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="429" mass="44504" checksum="AF3C1695A6E1F6DA" modified="2013-07-24" version="1">MELPLGEGTIDVDLPDCDVTVAEPPGGEPVDVPAAAERALDRPLGPSIANRAFPGDDVAIVVTDVTRATPDDVLLDALIGRLTNAGVERSDVTIVVGLGLHRPLTDDEIAEAYGEYADLVVNHDPDEATAVGHIDPAVAGEAERGSAGALGAQGVPIEVNPAVASADLVLATGMVEPHQYAGFSGGAKTVVVGAGGEPLIRYTHGPELLGRDGVRLGRIEGNPFRDFLDRAGELAGPDFCLNVTHGPSGILDVAAGSPRPVVRELADSAREALSVPVDRAYDAVVAGVGAPKDANLYQASRAATYVALGDRNPLREGGRIVVPAALPEGAGEGTGERRFLEWLSNGSSADAVYEAMANGYEPGAQRAFVLARVLREFDVYVTNSQAPAIVEDCLMRAEETVADAIEPGSDVLIVPDAIDTLLVDPDRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3K5</accession>
    <name>R4W3K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445481.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00587">
        <property type="protein sequence ID" value="AGN00587"/>
        <property type="gene ID" value="L593_03180"/>
    </dbReference>
    <dbReference type="GeneID" id="16182629"/>
    <dbReference type="KEGG" id="sali:L593_03180"/>
    <dbReference type="eggNOG" id="arCOG04646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021565_0_0_2"/>
    <dbReference type="OrthoDB" id="96861at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="13939" checksum="16C0443916F611B0" modified="2013-07-24" version="1">MNPPTLVFDDDCGFCTYWVEFVAERSDVTIVGFSELSEDLRERLPEDYEECAHLVTDGEIYSCGAAMEQAFLMTGLGGPVADAVRFASGFEEYDRVREAGYRWVADHRATLGKFVSRPPPARSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3N4</accession>
    <name>R4W3N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative unusual protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03430"/>
    <dbReference type="EnsemblBacteria" id="AGN00637">
        <property type="protein sequence ID" value="AGN00637"/>
        <property type="gene ID" value="L593_03430"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.694"/>
    <dbReference type="eggNOG" id="arCOG01189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="556" mass="63079" checksum="A602794813E6F72B" modified="2013-07-24" version="1">MPFLRPYWRFLRVLRQFLPLILAWWRDRRRFLLFGGRRAVSSEERTRRAEELLDTLLTLGPTFIKLGQLLSTRPDVLPPEYVSVLSSLQDDVPPAEWEDAKRVLEAELGPTELRFHEFDTEAISGASLGQVYRARIDDQDVAVKVRRPGVESLVAADLRVIRWSLPVLLLVVDEARAFSLRNLADEFDKTIREEMDYERERRMLDEIRANFADEPKIAIPDTIDSHSSERVLTMEYLGGTKVDRIDDLDRHGIDRTEVAETLQRAYLEMIVEHGVFHADPHPGNLAVQDDGTIVFYDFGMSGRVDEFVQDKIVEFYVAVAEQDIDGILDALIEIGTLSPQADRAVMAEVMELAIQDARGEDIEQYRIQQIVGQIEDSIYEFPFRLPKDLALVLRVATVVEGVCVTLDPNFDFIATATEYLTEEGYREETIRNVIEDTGDQLQRSGAAAVRIPPKLESALDRVERENVRVKAEIQDSNELLGLLAKRLLVGMLAAAGVVATTILYVAASIEATAVAAGATVFLLLVLYRSFRRRRGIRAQPQFTRQNLRARRGPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3U6</accession>
    <name>R4W3U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445621.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03880"/>
    <dbReference type="EnsemblBacteria" id="AGN00727">
        <property type="protein sequence ID" value="AGN00727"/>
        <property type="gene ID" value="L593_03880"/>
    </dbReference>
    <dbReference type="GeneID" id="16180686"/>
    <dbReference type="KEGG" id="sali:L593_03880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.788"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_4_0_2"/>
    <dbReference type="OrthoDB" id="71281at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="25529" checksum="BBA88E19939F74CA" modified="2013-07-24" version="1">MQNVTDRTSNPFGMSPPCEHRCSADVEAVFGYGDANADVHVVGDHPGVHGGAETGVPFSGTDTGLAVHEVLEAVDLLSDPGNEPRPEGTYLSYLHMCCPATGETPSPADYADLEPFFDAELRAIAAHVLVPVGERATAHVLKHFTAEPYADVALDGTAERAGFDDVAAGEAHLDMDALHAREVKGSGWLVLPLQDPSEWDEEGREAAIDGLETLLSRDYRQTTDLGRFLATDESYLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W460</accession>
    <name>R4W460_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04915"/>
    <dbReference type="EnsemblBacteria" id="AGN00932">
        <property type="protein sequence ID" value="AGN00932"/>
        <property type="gene ID" value="L593_04915"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1004"/>
    <dbReference type="eggNOG" id="arCOG01376">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="330" mass="35434" checksum="B94E3567E903F24B" modified="2013-07-24" version="1">MAGVDADGGVGAGQRVLVTGGCGYIGSALVPQLLDDDRVADVVVLDSLASGSPANLAGSVGEGLEFRRGDVREYGDVESATRGADAVIHLAAITGAASTHDRREETFAVNRDGTENVLTAAGKFDVESVVVASSCNNYGRVASTDIDETAEQNPLNPYAESKVASEELLADAINEHGFDGTALRMSTVYGWAPGIRFNLVVNHFVFRGLTGRPLTVYGDGSNWRPFVHVEDAARAYAEAALNPDTWSQQVYNVGRNDQNYRIETVAGVVREELDRSLDVTYLEEEHPGPSYHVNFDRLAETGYEPEWTLREGVRDVAAHLEGSEAEEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4C0</accession>
    <name>R4W4C0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445931.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05440"/>
    <dbReference type="EnsemblBacteria" id="AGN01037">
        <property type="protein sequence ID" value="AGN01037"/>
        <property type="gene ID" value="L593_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1110"/>
    <dbReference type="eggNOG" id="arCOG01490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_1_2"/>
    <dbReference type="OrthoDB" id="80798at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="75"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20596" checksum="1E82D2EDDB0E492D" modified="2013-07-24" version="1">MKTQYYTATSVDGYLADEENSLEWLFQFGAVEGVDDGYSQFVERVGALAMGSTTYDWIIEHEDLLKHPEMWPYEGPAWVFSTRELPAVDGADIRFVQGDVGPVHEEMVAAAAGENVWLVGGGELVGQFHDRGLLDEIVLNVAPVTLASGAPLLPRRITDPPLKLTDVERQGNGFAVLTYEVQRPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4G3</accession>
    <name>R4W4G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(R)-citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446006.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05815"/>
    <dbReference type="EnsemblBacteria" id="AGN01112">
        <property type="protein sequence ID" value="AGN01112"/>
        <property type="gene ID" value="L593_05815"/>
    </dbReference>
    <dbReference type="GeneID" id="16181506"/>
    <dbReference type="KEGG" id="sali:L593_05815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1191"/>
    <dbReference type="eggNOG" id="arCOG02092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_2"/>
    <dbReference type="OrthoDB" id="10632at2157"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="507" mass="53322" checksum="FC3A1A0C564F75FE" modified="2013-07-24" version="1">MGFSDTPIDDQTEVSLLDTTLRDGEQAPGVSLTPEEKAEIAQALDRAQVDVIEAGSACTGEGERRTIRRVADLDLDATVTSFSRGIKRDVELALDCGVDGINLVVPASDRHVETKVDSTREDVIASTEELVEFAVDQGLWVEVIGEDGSRADLEFLEELMATALDAGADRVCYADTVGHAGPERAYEVVSALSDLGPTSAHTHDDLGLGVTNALAAIDAGADMVHATVNGVGERAGNAALEEIVIALEHVYGIETVETEQLYELGQTVANATGIELPPNKAVLGENAFTHESGIHTDGTLKDDAMYEPYAPETVGRERRIVAGKHTGRAGAKAALEEHGIDVDGEELDKIVERVKAIGDRGKRVTDADLMTIAEEVTDGERERLVELVDMTAASGGGTPTASVRLLVDGEEHQAAATGSGPVDAAISAVRAVLGEKTASLDSYEVDAITGGHDAVVTVEVEMSRGDRSVSVRSSDADITTASVEAMVEALDRLLASDEDTEALLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Q8</accession>
    <name>R4W4Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446171.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06650"/>
    <dbReference type="EnsemblBacteria" id="AGN01277">
        <property type="protein sequence ID" value="AGN01277"/>
        <property type="gene ID" value="L593_06650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181831"/>
    <dbReference type="KEGG" id="sali:L593_06650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1358"/>
    <dbReference type="eggNOG" id="arCOG00076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_2"/>
    <dbReference type="OrthoDB" id="8883at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="142"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="493" mass="53195" checksum="A53B125477E47BCC" modified="2013-07-24" version="1">MKFDQARWSRDDAPVYEPLLSESDDRTVEVDVDLPDDLTRNELTLPDPAEPQLARHYTRLSEMTYGVEHGPYPLGSCTMKYNPWYVEDLAADPNALVHPDRSDEAAQGILAVMHRLQEDLAAIGGMDAVTLQPPAGAAGEFAGILIAKAYHEANGDDRSEVIVPDTAHGTNFASAAMGGYEVVELPSGEDGRVDVDALEGALSEDTAALMLTNPNTLGLFERDIEEIADLVHDVGGLLYYDGANLNALLGRARPGDMGFDVMHYNVHKTFATPHGGGGPGAGPVGVAERLAEFLPDPHVRKTTGAGEDSERAGEDSERAGATIPTFERYTPEHSIGKVHGFDGNWLVLLKAAAYIARLGDEGLSDASAKAVLNANYLASQLHYDVPYGPFHHEFVASAGDRDAAEVAKRMLDHGVHPPTTKWPEIVPEALMTEPTEVESRDSLDQLAAAFDAVQAEDDETLANAPERTAAKRIDQTSAARNPRLCWQDLDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4U5</accession>
    <name>R4W4U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArNOG05511 family protein (AAA-type ATPase core domain protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446231.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06950"/>
    <dbReference type="EnsemblBacteria" id="AGN01337">
        <property type="protein sequence ID" value="AGN01337"/>
        <property type="gene ID" value="L593_06950"/>
    </dbReference>
    <dbReference type="GeneID" id="16181939"/>
    <dbReference type="KEGG" id="sali:L593_06950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1420"/>
    <dbReference type="eggNOG" id="arCOG04368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646568_0_0_2"/>
    <dbReference type="OrthoDB" id="37046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="483" mass="53637" checksum="874548334DBA6D7A" modified="2013-07-24" version="1">MSNPELDVVEFLLTAKVYGDDRDLDENDLPPRYRSVFWSDGTIERPLATTNETARAATGLDRPWEAVQGLMFTDRDDFSGSISFTDRDLAEEWFIERADVDRLNSNPTLAAYFEGHEDAPDAVDYEVALEANRPIQADRVWIDSLLEEYFGADDEDDQEMLDLVDIRAPEEIETTLDDLVLTPDQEGEIDKIVTAIEHRDYLARIGLREIGKLLFVGPPGTGKTSTARGLAHELDLPFVEVKLSMITSQYLGETAKNVEKVFEVAKRLSPCILFIDEFDFVAKTRSSDEHAAIKRAVNTLLKSIDEISLVRDDVLLIGATNHPDDLDAAAWRRFDEIVNFPKPDSGMRADIFEIITREMVIDDFDPGALAGETEGLTGSDLRLVMREAVLSALTEGRTELNQDDLLAAIQDFEERDNLKNMDMIEGDHDALVAGGDISGGDEEEDAAADGGEARDSSRASSDHGSDGGHEHDHDHADHDHADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W526</accession>
    <name>R4W526_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446371.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07660"/>
    <dbReference type="EnsemblBacteria" id="AGN01477">
        <property type="protein sequence ID" value="AGN01477"/>
        <property type="gene ID" value="L593_07660"/>
    </dbReference>
    <dbReference type="GeneID" id="16182186"/>
    <dbReference type="KEGG" id="sali:L593_07660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1570"/>
    <dbReference type="eggNOG" id="arCOG00448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_2"/>
    <dbReference type="OrthoDB" id="83858at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="160"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="559" mass="62351" checksum="79112440FC04EF52" modified="2013-07-24" version="1">MPEIDPTEHEISELGPKVNQVEDVDELQEMLELEEGGEDRTPVKTLIESRIETLEAEDEEPEDAGEVDLSEKTTADVGNLIRDVDEVEDLEALLEQEESGEDRDSVKRLINQRIDSVQGSDDDGEEEEILPPEEAHPDLDHPTADKRHVRALEDGEYRDMWVYCETQHGELLDVSKEMLGKARELMDGYNEDYDEAEKVVAVVIGDDAEPIAEDTIEYGADLAVYYDDERLDRFRHKPYSEVFCDMARGAGHPYGREDRPDEDWHDYDEPRYAIFPATHNGRDLSALVQAELDSGLASDCSDLYIENEVISNPVKTGAKDKVEFERVLHMPRPDFSGFEYSTILCLDSPRREFHPQGASVIPGKFELPDPDPEREGEVVEHSFDLDDAWLDVEVTDHDRLEGGVDLTDHEVVVCVGRGIDRNPTEGIELGVELSEAFEDGAFGLTRGVITSSFQFAGHVEQYTGEDRQIGESGQEVEPDLYIAAGVSGAIQHKVGCEESDTIVAINTDEHADIRDWSDYYIHGDLFDVLPAFTEAVESGSVDSALEEFGAVPAAGGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5K4</accession>
    <name>R4W5K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446671.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09160"/>
    <dbReference type="EnsemblBacteria" id="AGN01777">
        <property type="protein sequence ID" value="AGN01777"/>
        <property type="gene ID" value="L593_09160"/>
    </dbReference>
    <dbReference type="GeneID" id="16182641"/>
    <dbReference type="KEGG" id="sali:L593_09160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1879"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OrthoDB" id="47519at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="356" mass="36992" checksum="9AF64EDDBBBAEC82" modified="2013-07-24" version="1">MHRSVLETLGSPLVQVDAPEGATVAAKLESANPGGSAKDRPALWMIRAAERAGELEPGDRIVEPTSGNTGIGLSLVAAARGYDISIVMPASKSKERRQLMRAYGAEIELVDGDISAARERAEAIAEEGAVLLEQFRNPANPQSHYESTGPEILDQVEGREIDAFVAGVGTGGTITGVGRRLREAFPDVEIVAVEPADNAVLSGDPAGDDAFQGMGPGFVSENLDVDLLDDVVTVELEAAEAECRRLAREEGILVGQSSGAASLAARQVAERIAEPSLECPPAGARSADQAVGDGTRSDGGASNSNGANGATDATNARDAKRDPDAAHETDAYDDCPLVVTIFPDSGERYLSAGVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T6</accession>
    <name>R4W5T6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ORF">L593_00165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444882.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00165"/>
    <dbReference type="EnsemblBacteria" id="AGM99987">
        <property type="protein sequence ID" value="AGM99987"/>
        <property type="gene ID" value="L593_00165"/>
    </dbReference>
    <dbReference type="GeneID" id="16181115"/>
    <dbReference type="KEGG" id="sali:L593_00165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.33"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
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        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
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        <property type="entry name" value="L30e-like"/>
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    </dbReference>
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        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
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        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGM99987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="39417" checksum="2E562CC5FE0B1632" modified="2013-07-24" version="1">MRIQDRYRVEGGAERITLVPDSLDDLWHLQYVVEPGDRVAGDTTRRITRDDEQLRDTGGEREHLWVEIAVDTVEFHKFANRLRIGGEIADCSREDQLGLHHTLNVEIHDEIEIEKHFAPDQIERIEEAEEATDQPDVAIATVEEGEAAVYTVEAYGTEERATITSTTGKGEFARDRDELFAELATVLGRMDADAIVLAGPGFTKQDALRYVEENDAELADRIRTVDTSAGGDRGVHEVLKRGAVDELREETRIAEEAELIDELTARIGSDEPVAYGPDAVAEATEFGAVETLLVLDDRLRVERAGEGEWSIDADHVVERVEQQGGDVVVFSGEFDPGQQLANLGGIAALLRYRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W654</accession>
    <name>R4W654_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01075"/>
    <dbReference type="EnsemblBacteria" id="AGN00168">
        <property type="protein sequence ID" value="AGN00168"/>
        <property type="gene ID" value="L593_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.220"/>
    <dbReference type="eggNOG" id="arCOG01274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="40916" checksum="075DC254E2A66F27" modified="2013-07-24" version="1">MSSDSAFVRATDAVMAQLRTRLRPVWDAICTVLAPLDRALQPVAGLYNRSLGRHFGTMTGLQFAVITLGFAMIATVPFWSPLYSETLNITFAVASIWAIFAMSWDIQSGYTGYISFGHSVLSGAAGYTIGLLILHYDPSMGPLTTIPIAVLASLVLGLVIAVPSLRLRGPYFSLITLVGVLLFTNLIFAFSEWTNGELGIHQVDPFTYEPWVRYYYMAIPMLAIAVGLTYVARSNVGMVLLTIRENERAVSSAGLDPTKFKISSFVLSSIPMGIGGALLVYYGRAINPVSFVEISNSIEIIALAVIGGMGSIIGPLFGSFLFFFLEEEFLRDFIDDSSTRTLVLWLFVLGVLVFARNGVFRVVWHGLGAVRGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W665</accession>
    <name>R4W665_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01150"/>
    <dbReference type="EnsemblBacteria" id="AGN00183">
        <property type="protein sequence ID" value="AGN00183"/>
        <property type="gene ID" value="L593_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.234"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_2_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="42498" checksum="1AE321F98F960766" modified="2013-07-24" version="1">MLKYYAYKATKAVEFYRPVMYLFFLAQGLSFTQIVVLEAIYNLTTVLGEIPTGYVGDRVGRRNSLLFGTVLIAVTLVGIGLAESFWAFAILYVCWSSGYNFRSGSEDAWLYDTLTDELSEDEFAHVRGRGEAAALAVGAGAAVAGGYLASVDLSYPWFVAAAVTGVGALVLVTVEESSTYEESDADQLGFRRTIEIVREVVAKRDLRAFLLYYYVLYAAVTYLVFVFLQPIFETVVVDLGVASGDVEALIGWFYAAYNIVGAGLSYFTGTIKRVVGVRTWFAVLPFLVGTALLAMYAVPVLALPTFLFARGLADVTRTFAGQYVNDRIDTLGRATVLSALAMVSGLAVIPFQLGSGVISDAVSPLFALAVGGAALVVGSAVIRLWESPVRTDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A9</accession>
    <name>R4W6A9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="L593_11260"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_11260"/>
    <dbReference type="eggNOG" id="arCOG08928">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11137" checksum="6FB6047FF4954544" modified="2013-07-24" version="1">MRESDANLDSGGVQEATTSESFDTVSTRRYTVGADEPLDVAIVYAVAATKGVGPMELEDPLNDVVDADALRQLFASGDESLSATIYVDGHRVTVAEGGRELIVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J1</accession>
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    </gene>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02360"/>
    <dbReference type="EnsemblBacteria" id="AGN00423">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="26764" checksum="F1240C55FFF33BDB" modified="2013-07-24" version="1">MLGDSYMRTRLALVLGLLLVGVVAVSIPAVAQDGSASTTNDSVDNVTVGQSISGFMQSTEASAESDVDQGVYEAEYEMANASERAALVEERSDSLETRFSNVEDRIERLQAQRDDLNPTAYRARMSAAAAQLRGLESSANATGEDAAAAGVNATRLETLRTRASELAGQEVAAIARSLAGVTPDAPGQGRSHDPGQVDDPGAPNGTPGASGNETGQPDGPGAGTGGQGNGTDAGSGQGTGTGSDRGTGSDQGTGSDQGTGSDQGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I8</accession>
    <name>R4W7I8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN00988">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG09407">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10902" checksum="CC34B171B3C7B6E5" modified="2013-07-24" version="1">MAQASRRIVAGQDSELHDEPHITDSRVTVRFVHERVEEGDLGPASFAEQYGVDLADVYHALAYYHDHPEEMRTVEERRSETIETHRADAITGPDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U3</accession>
    <name>R4W7U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00620</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00620"/>
    <dbReference type="EnsemblBacteria" id="AGN00079">
        <property type="protein sequence ID" value="AGN00079"/>
        <property type="gene ID" value="L593_00620"/>
    </dbReference>
    <dbReference type="GeneID" id="16181604"/>
    <dbReference type="KEGG" id="sali:L593_00620"/>
    <dbReference type="eggNOG" id="arCOG01622">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="179"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="43775" checksum="8C2231A9AA13F3A2" modified="2013-07-24" version="1">MTASFGIGVVSCGFITREMHLPSVEYLPDVHVGGIQNRTKEHAEDVAETCREEGWGDPSVYGEDRVAALVEDPDVDGLWVTSPNFTRVDVIDAAVDAVEDGADLQGIAMEKPVARNMEEANHIADRIRSAGIPNAYLENWPFEPDIAKLRDLLWERGGEAGRPYIARSQAEHGGPHSAWFWDGELQGGGALTDMLCHALAGNHVLLADPETEDGGLEPVSVSADTETLKWGREDYAEALREEHGVDWAENPSDDYARATVRYEGEDGEPLVSEATGSWCYVGSGVRRSIELLGPEYSGQVLTDDESSSVFFSDDLGEGEGWAEKQAATSGRMPIGAGAVFDGGYVAENRDAVDAFREGENGTLDVEDGLRVLRICMAAYKAAEHGEEVDVREADLSTYTPPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V2</accession>
    <name>R4W7V2_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">N6_Mtase domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">L593_06355</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446112.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06355"/>
    <dbReference type="REBASE" id="65151">
        <property type="entry name" value="SspHBORF6355P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01218">
        <property type="protein sequence ID" value="AGN01218"/>
        <property type="gene ID" value="L593_06355"/>
    </dbReference>
    <dbReference type="GeneID" id="16181432"/>
    <dbReference type="KEGG" id="sali:L593_06355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1295"/>
    <dbReference type="eggNOG" id="arCOG02634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251831_0_0_2"/>
    <dbReference type="OrthoDB" id="3686at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="2">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1400" mass="158515" checksum="3B15AF5684F9960A" modified="2013-07-24" version="1">MASDSLSHHKAQLDKEEREHLEDVVADMRERVEDNVRFQLTQHGLGDEPEDRSALDEEAEQLVEAIELEAVDGNTWGEAFEQYVTGVGYTIVNRLAALRCMEVRDFVDEEVTVFKDNGLTPAAETLVTEEFLLEEEAILQAYHDACDDLAAEIEILFDRSSAYSQVDPDDDTFDDLCGMLDSVPDEVWRADDVLGWVYEYYNRPVVEALDAKNTLAPEDVGPANQFYTPHWVVRMLTDNSLGKLYLEATDQTDAIPEPEALSPEERKDRLVTPADAPSVTDLCTYLIPDEEPGEAPEFDHPRELRVIDPACGSGHFLLYAFDVLERIWWAETDLDRAAIPEKVLEHNLYGVDIDLRSCQLSAFNLYLKARTRAEAQDGQFEMPNVGIVCADARVAEVDEATDVLDDITGEGSDLREELDDVTETFQHTEALGSLLDVGGTLEEAFDSSKMQAELSDYNGGAHQSLHSFLKALRRAVADQTNDSFREQNLRSFLHLLAVLTQDYDVALMNPPYGSGGRMPSSVQAYVEEHYEYMTEYYANFFEACDRLARDGGRVGMLVPRSFLFNQTLEPFRADFIGNRGSFDFLAEFGYGILDNATVGTAGTVVRSGSSQDTVGSFIRLHDVEKGDKEATYLRTAFTSREDDEIVRHFEIAIDEFNEIPGRTLCYSLPEKIRDLHSSDRKIGVEDDTGGVERIADVKQGLATGDNSRFLRAHWETSSSDFQPFTNAGGKVWVLPEVDEVIDWTDSGSRIRRYSGSRFQNTQYYHREGLTWAYIKRTGRRFGYYPDGGLFGHASNMIFPISDISLWSLLGVLNSDAYHGLMLCLTPERKWEAGYVGKLPWFKKLEGRADLAEKVKEQYRTMIKQSVHNFGSPYYIGPVLLPESRRPTFFYTEHDHQRAIAAEPDTLFETGQTDETLLERSRQAVVLDRRRQKRIETLADEIDQEIFQALGVDSATRNQVKEEIWLRTVEEKSDREVPSPDEVPEYPEIFPKQIKDLILHLALCAVRRADDGIIPVSDVEGEDDLLTHITAEFERVWGDHADARLAEVDDVLGRKSAGEAAYPNLRTWLEEDLFDYHVSKFDRVPILWRFTTERLVSDSEGEGFGCLVDYHQLDGGAFDGLQNRYLEPRKNRLRERRSAANRRRSDDSLSASKQAEAAEEYARCESGLEQISVLEDRLAELAQPEPRQWSTEEQAAADAAAKRVAEFRRRTEKRLEIVDELAAMDDVDVGELFTGNFYEKIENQREEWIDALGDLEAAFDAYAADSEQPVGAHLYDLFDYYTDDLLGSSHFASNGILYMTYYFDEFEQADQGRLGDAGVARRQRLISQLARDLDEYIDLGEAIAEDCEELSSEISSDWEDRALSEITAAGYQPNHKHGVEINITPLAEAEIVPETVEEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V7</accession>
    <name>R4W7V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445003.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00770"/>
    <dbReference type="EnsemblBacteria" id="AGN00109">
        <property type="protein sequence ID" value="AGN00109"/>
        <property type="gene ID" value="L593_00770"/>
    </dbReference>
    <dbReference type="GeneID" id="16182101"/>
    <dbReference type="KEGG" id="sali:L593_00770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.158"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="149" mass="16077" checksum="5B516DADCD67700E" modified="2013-07-24" version="1">MYDRILLATDGTEASTDAATHAIDLAADTGATLHVLYVVDETVYSAYSGDEYVDEAEGPEHGLEEVGEEAIEEIRDRAASAGVEVESAMRHGTPSRTIVEYADDADVDLIVLGTKHRPAEYRALLGSVTDRVLRLTARPATVIKTTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W888</accession>
    <name>R4W888_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine dehydrogenase</fullName>
            <shortName evidence="1">AlaDH</shortName>
            <ecNumber evidence="1">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ala</name>
        <name evidence="2" type="ORF">L593_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446467.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08140"/>
    <dbReference type="EnsemblBacteria" id="AGN01573">
        <property type="protein sequence ID" value="AGN01573"/>
        <property type="gene ID" value="L593_08140"/>
    </dbReference>
    <dbReference type="GeneID" id="16180011"/>
    <dbReference type="KEGG" id="sali:L593_08140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1670"/>
    <dbReference type="eggNOG" id="arCOG01035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_3_1_2"/>
    <dbReference type="OrthoDB" id="96993at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00935">
        <property type="entry name" value="AlaDH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028609">
        <property type="entry name" value="AlaDH_arch-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="335" mass="35343" checksum="581736AE021999D1" modified="2013-07-24" version="1">MQTLLLDSDAVAANAQMPDVIPAVEEAFAADDRGDVQMPAKSYIELEQYNGDFRSMPAYLDVTGSATAEEWDAAAVKWVNVHPDNPSDHDLPTVMGTLIYSDPETAYPLAIMDGTELTLQRTGAAAAVATDHLAIEGATSLGIVGAGVQSYSQLEAIAEIRPIETVVVSDVDDARVAAFVEAFGDQFDVRGGSIEEAASCDVLSTVTPVREPIVPREALGEHTHVNAIGADAAGKQEHEAQTLLDAKVVIDDYEQCTHSGEINVPWASGEFGEDDLYGELGAIVTGHVEGRTADDGITLFDSTGLAIQDVAAAHVVYERATADGEGTPFDLLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B0</accession>
    <name>R4W8B0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446517.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08390"/>
    <dbReference type="EnsemblBacteria" id="AGN01623">
        <property type="protein sequence ID" value="AGN01623"/>
        <property type="gene ID" value="L593_08390"/>
    </dbReference>
    <dbReference type="GeneID" id="16182388"/>
    <dbReference type="KEGG" id="sali:L593_08390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1719"/>
    <dbReference type="eggNOG" id="arCOG01781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085884_0_0_2"/>
    <dbReference type="OrthoDB" id="65428at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="227" mass="25618" checksum="D46E9FCA32303D00" modified="2013-07-24" version="1">MSVREEFDDWAAEGRDRGMEERHWHTAKHALSAMPVEAGDTVLDFGSGSGYAARALREAADAGRAIGVDGAPEMVGNAREYTDTEEPVEFVAADFHHLPLPDDSIDHAFSMEAFYYAANPHEALAELRRVLRSGGTFYCGVNYWEEHHYSEGWQENISIPMTRWSEAEYREAFREAGFHLAGQTRIPDTESEIPPKSEFPTEWYDSPAEYRESDREYGTLFTVGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H1</accession>
    <name>R4W8H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_09115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446662.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09115"/>
    <dbReference type="EnsemblBacteria" id="AGN01768">
        <property type="protein sequence ID" value="AGN01768"/>
        <property type="gene ID" value="L593_09115"/>
    </dbReference>
    <dbReference type="GeneID" id="16182764"/>
    <dbReference type="KEGG" id="sali:L593_09115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1869"/>
    <dbReference type="eggNOG" id="arCOG02784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_2"/>
    <dbReference type="OrthoDB" id="107648at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="240" mass="26879" checksum="D9B02F8445A6F7F7" modified="2013-07-24" version="1">MCGRFTIFANAGELGERFSVDVPAEYAPRYNVAPSQSVPVIGNDAPEQLQFRTWGLLPSWADDPSEHGYVNARAETVEDKPSFRTAVRRRRCLVPADGFYEWTGDRGSRQPYRIAFEDDRLFAMAGIWERWEGPVQQTGLDDFAGGETAADAADEPRTEVRETVAILTTDSTGPVADLHDRMPVIFPRDREREWLDADDPEERADLLQPFAAPDFQAYRVSRAVNDPSNDSPDLLEPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S0</accession>
    <name>R4W8S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10465"/>
    <dbReference type="EnsemblBacteria" id="AGN02038">
        <property type="protein sequence ID" value="AGN02038"/>
        <property type="gene ID" value="L593_10465"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10465"/>
    <dbReference type="eggNOG" id="arCOG06291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835810_0_0_2"/>
    <dbReference type="OrthoDB" id="91849at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="34884" checksum="0595624CDE72D98E" modified="2013-07-24" version="1">MGIVIRCIAPSAAQNRAISTVLDAAIFLLLVSAAIGLLYTVPQTGDDARADPDVAAETTTTLATSIATIDYVPTADGDADSSTTNRSDRGTITELLAETTVANAELRGEAFTRAPNHEAAVRNATRRTIRRIDGDVEVQVRTRWRPLSGSGLRGGIVVGPSPPADADVHAATMRVPVGTGTSVGAARPDWFAPTAPPWTELETVESADDRRFGRRTSLETVTARGDCRGLAGVLAARAVGTAFPPEQTAIAMREESNAAEAIETRYVTAGRALGLRQDGLPLNDDVRHLSGFLAGELAAPFQAACEGYETPEIAASRAAPEIVTVSVRTWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W6</accession>
    <name>R4W8W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ORF">L593_05225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445888.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05225"/>
    <dbReference type="EnsemblBacteria" id="AGN00994">
        <property type="protein sequence ID" value="AGN00994"/>
        <property type="gene ID" value="L593_05225"/>
    </dbReference>
    <dbReference type="GeneID" id="16181279"/>
    <dbReference type="KEGG" id="sali:L593_05225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1067"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OrthoDB" id="87367at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15966" checksum="E6CB8C19D78B2E53" modified="2013-07-24" version="1">MSAAEFEADLVVDARDAILGRVASQVAQAALDGDSVAIVNAEGAVITGDREDIFAKYRKRREIGSDRGPAYPKRPDTIMKRTVRGMLPHKKQRGREALGRVRAYVGNPNDQEAEHLPDTSLDRLSNIRFVHLGEVSEQLGANVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X6</accession>
    <name>R4W8X6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl23</name>
        <name evidence="5" type="ORF">L593_11115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447062.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11115"/>
    <dbReference type="EnsemblBacteria" id="AGN02168">
        <property type="protein sequence ID" value="AGN02168"/>
        <property type="gene ID" value="L593_11115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180049"/>
    <dbReference type="KEGG" id="sali:L593_11115"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="9804" checksum="0CCFA4E98892CEF7" modified="2013-07-24" version="1">MSANSGKAVIKHPLVTEKAMNDMDFENKLQFAVRTDAAKPEIAEAVEEQFEVEVTSVNAHVTMKGYKKAIVELGEDYDADEVASRIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z3</accession>
    <name>R4W8Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02198">
        <property type="protein sequence ID" value="AGN02198"/>
        <property type="gene ID" value="L593_11265"/>
    </dbReference>
    <dbReference type="GeneID" id="16181380"/>
    <dbReference type="KEGG" id="sali:L593_11265"/>
    <dbReference type="eggNOG" id="arCOG05170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170793_0_0_2"/>
    <dbReference type="OrthoDB" id="115943at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="10420" checksum="BEA30F3D0609976A" modified="2013-07-24" version="1">MNDEWDEIGYVISSNYRTEVLGCLANGPATPSRIADETDISIAHVSRALQELRERSVVELLVPEDRRKGRIYGITEKGDRVWAEMDAENLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W912</accession>
    <name>R4W912_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11550"/>
    <dbReference type="EnsemblBacteria" id="AGN02253">
        <property type="protein sequence ID" value="AGN02253"/>
        <property type="gene ID" value="L593_11550"/>
    </dbReference>
    <dbReference type="GeneID" id="16181676"/>
    <dbReference type="KEGG" id="sali:L593_11550"/>
    <dbReference type="eggNOG" id="arCOG02848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07873">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113891_0_0_2"/>
    <dbReference type="OrthoDB" id="72109at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="30516" checksum="7941FCAAFB023C83" modified="2013-07-24" version="1">MTAAGTAICDACDREGPVQQLAEVILPSGPMTVCPECRYHAEELAARSTVDCEGCGETVTATDLSRTALPDGTDMILCSNCRTDVSAGERPGDADGRSEADGSETPEDTTANEAGSTPDDASAGAGSETGRSKRATGSGGPSTAHDPGATGDASASAGSDARTGSNGKTGTDACGSAATGEAVTDGATGKPATTQTACDQCGGLYSIELYRVTTVDGRTERFCPDCKDDGIEQGIVSDVELRRAQAYEALGLEGSASSDDVRQAYLEQVKEVHPDRSDGSRSEFMLVQQAYERLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W934</accession>
    <name>R4W934_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447217.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11900"/>
    <dbReference type="EnsemblBacteria" id="AGN02323">
        <property type="protein sequence ID" value="AGN02323"/>
        <property type="gene ID" value="L593_11900"/>
    </dbReference>
    <dbReference type="GeneID" id="16180682"/>
    <dbReference type="KEGG" id="sali:L593_11900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2449"/>
    <dbReference type="eggNOG" id="arCOG09005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110570_0_0_2"/>
    <dbReference type="OrthoDB" id="110639at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="21248" checksum="95EA373D4904CE8E" modified="2013-07-24" version="1">MPEIEITEDQHEYLEALREDIQQDVVGKYAHVRMVDAVQYLIDNHEGEINATVTAPSAGPEVSAENAPAADPVEESSEDDAEDDAEADDEPEEEADADESEDAEETAEDGAEADDDAEDDADADEEDSGGTTSSPPMAAAAGGDDDGMLSAMMALMDTHDDKWEEASGDTGYEVELPDGSTESAGTQDDVRALLFKHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W950</accession>
    <name>R4W950_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447267.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12150"/>
    <dbReference type="EnsemblBacteria" id="AGN02373">
        <property type="protein sequence ID" value="AGN02373"/>
        <property type="gene ID" value="L593_12150"/>
    </dbReference>
    <dbReference type="GeneID" id="16182724"/>
    <dbReference type="KEGG" id="sali:L593_12150"/>
    <dbReference type="eggNOG" id="arCOG06283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119363_0_0_2"/>
    <dbReference type="OrthoDB" id="107129at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="18876" checksum="E8082382C2664539" modified="2013-07-24" version="1">MRFKTVPPAPPENVPAAEALRTVRDALPLVPRSQDDCCGRLVDRVAWIEERDVATEWIGFLRALGLAERSDAGYSRVRDDVDTDALATRFRANVVGVGATIDALEAQEEPQTAGEVFEAIESTVPEWERRRSDTWHEEWNDHTERLLAWATALEIATAVDDGYRLSASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W977</accession>
    <name>R4W977_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06460"/>
    <dbReference type="EnsemblBacteria" id="AGN01239">
        <property type="protein sequence ID" value="AGN01239"/>
        <property type="gene ID" value="L593_06460"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06460"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="38065" checksum="8EA3EB88B8D05CBE" modified="2013-07-24" version="1">MSDTPDADASEPADATDHDAPDHDVDAPDHDVDGIAVVGAGRMGHGIALTYALAGHPVRLFDVDEETLASSPDRIADALDTFTERGRYSESAATDALDRISLHTDVAEAVDGVDFVTEAVAEDAAIKQAVFEDLDEHAPADAILATNTSGISIDEIAGPVEDASRVLGTHWFNPPHLVPLVEVVKGSATTDAAAQRIRALLEDADKTPIVVQKDVPGFIGNRIQAAMSYEAFSLLARGVATPQDIDRAVKAGFGFRLPIMGIFEKMDQSGLAIHHEVEKRLMGDLDRGTDPNPVIEELLEEGYTGTETGKGIYDWTDVDLESVRERRDGALLDMLDLYEESDAESSPPAYYDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W981</accession>
    <name>R4W981_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447357.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12620"/>
    <dbReference type="EnsemblBacteria" id="AGN02463">
        <property type="protein sequence ID" value="AGN02463"/>
        <property type="gene ID" value="L593_12620"/>
    </dbReference>
    <dbReference type="GeneID" id="16181292"/>
    <dbReference type="KEGG" id="sali:L593_12620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2590"/>
    <dbReference type="eggNOG" id="arCOG01783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_3_2"/>
    <dbReference type="OrthoDB" id="42003at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="28462" checksum="D6BF8D7CF2C1891F" modified="2013-07-24" version="1">MAEDGAVDNEWEADRYEADHAFVYESSQDLVELLDPAPGERIADLGCGTGHLTAAIAREVDHPDGGPSGHAIGFDRSASMVAEARSSYPAVEFLQADARSLPFDATVDAVFSNAALHWISDQEAVVSSIHDALRPGGRLVAELGGVGNVATITDALEAELVERGSPGQHGWYFPSPGEYATLLEAGGFEVRDLRLFDRPTPLDGADGLEHWIEGFGDELLDPLSDDERSAVIEAVEDRCRTDLWTGEEWVADYRRLRVVAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C0</accession>
    <name>R4W9C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_07085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446258.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01364">
        <property type="protein sequence ID" value="AGN01364"/>
        <property type="gene ID" value="L593_07085"/>
    </dbReference>
    <dbReference type="GeneID" id="16182000"/>
    <dbReference type="KEGG" id="sali:L593_07085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1448"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003088_0_0_2"/>
    <dbReference type="OrthoDB" id="5636at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="292"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="681"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="854" mass="88020" checksum="42E70268D61296ED" modified="2013-07-24" version="1">MSPALATWLTEHARVAIAALLLATLLVGAGVPMVERSTSLDQFQADDPAADALDYAGENFSSGQSDATTAQVVVRDENVLDRESLIATLEYQQRLQTDDRVGDTLVEDGGTRSVANVIATAAIREHGAPANGTAPGAPSGSSESDPTLQAQIDALESLSEAEIDAIVAETLSTESERSGRDGATPLAFMPHDYEPGSTEANATLLVVTHDSAGGSFAPGDAPAEIEAAQTAIAALAPEDGSLSVLVYGDGVVSTEITNSMVDSVLLLGPLAAAFVLVVLLVVYRDLLDVALGLLGIALVLVWTFGAMGWIGIAFSQPFVVVLVLLIGLSIDYGLHVVMRYREARESSTTPPRRAMAVGLGSVGVALAYVTTTTVIGFLSNLASPLAVFRQLGVVSAIGILAAFVVFGALVPALKVELDSALEARGIDRLQPAVGTDAGGANRVLVMGATLARRAPVTVLAIALLVSGVGAVGATTIDASFEQSDFLAEDPADWLKDLPGPIAPGTYTAESAIDALDSDFVRRDTTASVLVRGNVTDPATLDRLDAARTDARGMSATETYADGDPAVTDPLTVMDRVAARNDSFAATLDASDVDGDGVPDRNVAGVYDELYRVAPDDASAVVHRSDGEYRALQMVVTLDGAASDAAITEQMEDLAGTADGESVTAIATGDVIVNQLTADQLARTAMTSLVVALVAVLLVLAVAYRVTEGSASLGVVTVVPVAFTLTWVLGTMAALDIPFNVVTGMITGLTIGLGVDYSLHVSERFNQAIETTDDVGEALETTVTGTGGALLASATTTASGFAVLLVAILPFLQSFGLITALTIVYAFVASVFVLPSLLALWARFVDVGPRSSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E0</accession>
    <name>R4W9E0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate ferredoxin/flavodoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447482.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13245"/>
    <dbReference type="EnsemblBacteria" id="AGN02588">
        <property type="protein sequence ID" value="AGN02588"/>
        <property type="gene ID" value="L593_13245"/>
    </dbReference>
    <dbReference type="GeneID" id="16180483"/>
    <dbReference type="KEGG" id="sali:L593_13245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2710"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="310" mass="34235" checksum="B3E9E81ED8BD9714" modified="2013-07-24" version="1">MSAFNAIGQEREIESDEFTPGIEPQPTWCPGCGDFSVLKALKQALPEVGRTPEETLLCTGIGCSGKLNSYLDSYGFHTIHGRSLPVARAAKLANPGLEVIAAGGDGDGYGIGGNHFIHTARENHDITYIVFNNEVFGLTKGQTSPTSPKGHKSKTQPHGSAKSPLRPLSLSLTSGASYVARTAAVNPNQAKEILIEAIEHDGFAHVDFLTQCPTWNKDAKQYVPYVDVQDSDDYDFDVTDRQEAAEMMYETESALYEGTVLTGRFYKDDRPSYSEEKQAIGEMPEEPVVERYFDDDAEWKRSYDLLDRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K1</accession>
    <name>R4W9K1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">L593_13920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447617.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13920"/>
    <dbReference type="EnsemblBacteria" id="AGN02723">
        <property type="protein sequence ID" value="AGN02723"/>
        <property type="gene ID" value="L593_13920"/>
    </dbReference>
    <dbReference type="GeneID" id="16180955"/>
    <dbReference type="KEGG" id="sali:L593_13920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2848"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_2_0_2"/>
    <dbReference type="OrthoDB" id="123606at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="44" mass="5214" checksum="434C524B752D3FDB" modified="2013-07-24" version="1">MSRHELYGDDGEIDRQPCPRCEDTFLGEHEDRLHCGKCGYTEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L2</accession>
    <name>R4W9L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446508.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08345"/>
    <dbReference type="EnsemblBacteria" id="AGN01614">
        <property type="protein sequence ID" value="AGN01614"/>
        <property type="gene ID" value="L593_08345"/>
    </dbReference>
    <dbReference type="GeneID" id="16182380"/>
    <dbReference type="KEGG" id="sali:L593_08345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1710"/>
    <dbReference type="eggNOG" id="arCOG04285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026574_3_0_2"/>
    <dbReference type="OrthoDB" id="26171at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="262"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="48703" checksum="B13FFB10991816DD" modified="2013-07-24" version="1">MTTTGEIARFVRETEFDDLPDDVVDATKRRILDSVGIALGAVGAAPVEAVRRTVHEDGGLDCCMWASEGRASISGAAMYNTVLTRYLDFMDSFLAPGETPHPSDNVGTVLAVGEHVDASGEDLLAATAIAYQLQGELAWAAPVRDRGFDHVTHTVLTQAAAAGKLLQLDHEQLQHAIGIAGTAHNALRVTRTGGINEWKGVAAGNAARNGTYAALLASNGMEGPTDLFEGQKGWQQVISGGDFALDLDPPCPRLHDVMCKRYVAETYAQSAVEGIVELANTVALDPDAVESIDLSTFHGAKLIIGGGEGDRHVVETKAQADHSLPYMLAVAAIDRELLTRQYEPERIQSDDVQRLLRTVSVEEDPALTERFEAGEMPAVIDVELADGTVHHVEKDAFRGHPTDPMDWDDLDEKLRPMATDVYGEHRWANVTECVQSLEDRSVHDLLELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L5</accession>
    <name>R4W9L5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446513.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08370"/>
    <dbReference type="EnsemblBacteria" id="AGN01619">
        <property type="protein sequence ID" value="AGN01619"/>
        <property type="gene ID" value="L593_08370"/>
    </dbReference>
    <dbReference type="GeneID" id="16182360"/>
    <dbReference type="KEGG" id="sali:L593_08370"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1715"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OrthoDB" id="102399at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="190" mass="20213" checksum="07A0129A825CC119" modified="2013-07-24" version="1">MRLFVSVDLPEDLADAVADVQEPFGEASGVRLIDPEQAHVTLKFLGDVPETTAGDDPDLDATVDAIAAGVADADVGSFEVGVRGLGAFPSPEYIRVLWVGIDEGAGELLALQRAIEERTVGLGFDPEEHEFTPHVTIGRMDHAGGKGHVQSVLEERSPDVGTFEVDAVTLTESTLEDDGPVYETVESFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N8</accession>
    <name>R4W9N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447727.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14470"/>
    <dbReference type="EnsemblBacteria" id="AGN02833">
        <property type="protein sequence ID" value="AGN02833"/>
        <property type="gene ID" value="L593_14470"/>
    </dbReference>
    <dbReference type="GeneID" id="16181259"/>
    <dbReference type="KEGG" id="sali:L593_14470"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_0_1_2"/>
    <dbReference type="OrthoDB" id="65191at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="272" mass="29280" checksum="F3F767E4B9455C6C" modified="2013-07-24" version="1">MTWQTIAKKDVRAVGDSRLFRYVLGFVVFAYLVGGYLVPTVIDSPATADLPRYVSTAVTLLVPLTAILLGYKAIVDERASGRLVLLLSLPHSRRDVLVGTFVGRALVLVGTLVAGVAVATALVAYPFGSFQPVDFLVYLGATILLGLAFLSIALAISAFTESSSIATAVAFGVFFLFVVVWSELRILFRLGLDSLGMGSDELPAWALFVHGLEPSACYERVVGGFVEHSTTGMYLHPDAPWYLGEEVALVALVAWVILPVTMGYVRFRGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q9</accession>
    <name>R4W9Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446588.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01694">
        <property type="protein sequence ID" value="AGN01694"/>
        <property type="gene ID" value="L593_08745"/>
    </dbReference>
    <dbReference type="GeneID" id="16182525"/>
    <dbReference type="KEGG" id="sali:L593_08745"/>
    <dbReference type="HOGENOM" id="CLU_1811531_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="14542" checksum="D61FC8DEEE0912E2" modified="2013-07-24" version="1">MVYTDPDEVPWSAYLALAGVMAVIVGALLPWYAALGESTTGLQHEDGYITAGVVLATLAFGVTFEWDLIAPVAAALAGAVTVIVGYDAYSQVSDLGTHDPKAGLWLTLLGGVVLLVAAGWGLLEGRVIATDAGENVRGDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R1</accession>
    <name>R4W9R1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="2">DHNA-CoA synthase</shortName>
            <ecNumber evidence="2">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menB</name>
        <name evidence="4" type="ORF">L593_14920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447812.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14920"/>
    <dbReference type="EnsemblBacteria" id="AGN02918">
        <property type="protein sequence ID" value="AGN02918"/>
        <property type="gene ID" value="L593_14920"/>
    </dbReference>
    <dbReference type="GeneID" id="16181574"/>
    <dbReference type="KEGG" id="sali:L593_14920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3047"/>
    <dbReference type="eggNOG" id="arCOG00240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_7_2"/>
    <dbReference type="OrthoDB" id="39623at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <sequence length="312" mass="34273" checksum="026C889228FDE8CB" modified="2013-07-24" version="1">MPSAIMDDSRWEAIEELDLQDVTYHRATDVGAVRIAFDRPDVRNAFRPRTVDELSAALDHAKRQTDVGCVLLTGNGPSSKDGGWAFSSGGDQRIRGADGYEYREDEDDAANGAESPSDTSAEPPEGADVGRLHILEVQRQIRHIPKPVVAVVPGWAVGGGHSLHVVCDLTIASDEHAKFKQTDPDVASFDGGFGSAYLARQVGQKKAREIFFLGKTYDAAEAAEMGMVNEVVPHEELEARALEWAEEMTSKSPTAMRMLKYAFNLDSDGLVGQQVFAGEATRLGYMTDEAQEGRDAFVEGREPDFDEYPWRY</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="248" mass="26230" checksum="4255A8C91960E4C2" modified="2013-07-24" version="1">MTRFGRLDAEFGVALRSFLRRRTAVFFTFLFPTILVVIFGALVQTDPGSGGLFAESPAYYVPGYVAVVVLFTPLSRMSSEVARHREGNRFEKLATTPLQRSEWLAAHVAVNVAIVGLAAALILGLVVALTGAPLGDVWLLPLFLVPGIVGFCGIGTILGRVTDSRDGAVAASNTIGLPLLFLSNTFVPPSQLPGWFGPIVNLSPLTYFARGARSAMYGGGSPWFDLAVLSGFAVLAFAVAAVAIPQTD</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Patrushev M.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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    </evidence>
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    </evidence>
    <sequence length="149" mass="15033" checksum="C94FE44ED8961764" modified="2013-07-24" version="1">MVELECTTARPGGVTLVAVRLDNRVESPGVDVHRIRLRSRIDGPTWPPRVQGVPAAPWDGDAAEVVVPTGQVGSIGFASPEPPVEPPVEIESVEPADPDAGSGPGDDPTAEDVLRVLGDPSPPRDAVDPTASPGATAGATGGTGPEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T8</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Harcht-Bsk1</strain>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="122" mass="13362" checksum="0784DF346C70F75B" modified="2013-07-24" version="1">MGQPSGIDEPTAAGQPSVVVPPIDVYETADEVLIHVDTPGFEEDEIELRADEQTLLVTAVREQEPEEGRSPLLLERPTHLERVVQIPPGADVEGAKATHDDGVCTVTIPKTESRRRRTIAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U3</accession>
    <name>R4W9U3_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">L593_09295</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09295"/>
    <dbReference type="EnsemblBacteria" id="AGN01804">
        <property type="protein sequence ID" value="AGN01804"/>
        <property type="gene ID" value="L593_09295"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09295"/>
    <dbReference type="eggNOG" id="arCOG04769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089552_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="29348" checksum="F1144605A3995233" modified="2013-07-24" version="1">MPEDGGPSNEPNDGDEPDQATAEPDDFEADDQPAADAPADPFDQRVAPYSGESTVDVDPVTPPERGDEDVEPDLPQEAIDEAERLTRLARRVPDDAETEAYRERRATLLAEHDYAAHVREDTDTGAGGAAGDADGPTLVCHPVEWLDGEGSIDPAEIETVDRAAEVHLGAAGDPEAWDAVAGKNDAVVEAIRESHGEDHGANAEAFATYVSNHHAKPIAAVTADELAWFREEYYPRNVWPTDEQRASLDRSLELVYEELEVPMPGRSSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U6</accession>
    <name>R4W9U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfi</name>
        <name evidence="3" type="ORF">L593_09370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446713.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09370"/>
    <dbReference type="EnsemblBacteria" id="AGN01819">
        <property type="protein sequence ID" value="AGN01819"/>
        <property type="gene ID" value="L593_09370"/>
    </dbReference>
    <dbReference type="GeneID" id="16182689"/>
    <dbReference type="KEGG" id="sali:L593_09370"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1927"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_2_0_2"/>
    <dbReference type="OrthoDB" id="80668at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="29654" checksum="FA816E979540C58A" modified="2013-07-24" version="1">MVSIQHPEYVPDPSLDREDMEALQRELAADAVFGDAFDFDPTAIGATATADARQTELDGKSSSPVTDELPIVAGIDQAFQASDGSQAGPGEFDEAVSAVVAMQDGEVIERVFAASPLEIPYVPGLLSFREGRSILAALAELSVEPDVLLLDGSGRIHFREAGIATHIGVTVDVPAVGVAKSLLCGTPRWADAGVAGGEPLDAGTIVPIAADDSMETPPGTIVGAAVQTRQFASGNRSINPLYVSPGHRVGWETAAQIALATAGEYKLPEPIRLADQWVGELTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V2</accession>
    <name>R4W9V2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446743.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01849">
        <property type="protein sequence ID" value="AGN01849"/>
        <property type="gene ID" value="L593_09520"/>
    </dbReference>
    <dbReference type="GeneID" id="16182742"/>
    <dbReference type="KEGG" id="sali:L593_09520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1960"/>
    <dbReference type="eggNOG" id="arCOG04484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093038_0_0_2"/>
    <dbReference type="OrthoDB" id="102333at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026272">
        <property type="entry name" value="SdpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37810:SF5">
        <property type="entry name" value="PTHR37810:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038959">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="24040" checksum="5F0F313B16216914" modified="2013-07-24" version="1">MRATVSTRTTRYVGGGLVLLGVLAGVLAWPELPATMDVHWNASGEADGTAPRAVGALLLPAVAAILLGVFDQLPRIDPLGENVADFRGYYDGFVLLLVAFLIGVHGVVLAANLGFDVPLSPVVLVATGGFLAYVGLLMRHAEPNWFVGVRTPWTLSSEEVWRRTHALAGWLFALAGVALAVAGVLGWLLDAEGAMTTAVLGIVLVASFVPVGYSYYLYRSLGGPEDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W9</accession>
    <name>R4W9W9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446828.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09945"/>
    <dbReference type="EnsemblBacteria" id="AGN01934">
        <property type="protein sequence ID" value="AGN01934"/>
        <property type="gene ID" value="L593_09945"/>
    </dbReference>
    <dbReference type="GeneID" id="16182499"/>
    <dbReference type="KEGG" id="sali:L593_09945"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026973_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="236"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="463" mass="48852" checksum="52F00F628520C679" modified="2013-07-24" version="1">MNGEQFEPGVERTDRWRGIGVATVVAAKLGLLTRQPPLLLVGGVGVALLAYARLVAPPPATLAVRRTIDDADDCATDGGNVTCEVDDGEPVPASGGDGSDRRTGPAGADARTHRSVTLTVENVGDRTLPHVRLVDALPAGIEVVDGTPGIGTTLRPGDVATTTYTVAVRSGTHAFERPFAVVRDVAGVVERRARLPVDDGRTVEADATTRLRESPPLRTRSARFAGDHPTDDRGEGIAFESVREYRHGDAPSRVDWGRFARTGELATVDYRQDRGASVVVAVDARPVAVRAPSSDRPTAVERALDAASAIADRFDADGHQVGVARLGPDRRWIGPGSGAAHRRQIEALLAERPRSVTSPGAATPSGSSTVAWVRERLGSRAELFLLSPLLDGDAVELATRLDATGTPVTVVSPDPTDDATAGRALAGIERSHRVASLRGAGLPVVDWPADRPLERAIPREVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y4</accession>
    <name>R4W9Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10320"/>
    <dbReference type="EnsemblBacteria" id="AGN02009">
        <property type="protein sequence ID" value="AGN02009"/>
        <property type="gene ID" value="L593_10320"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10320"/>
    <dbReference type="eggNOG" id="arCOG13571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187823_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="233" mass="25436" checksum="A6379B2E726DB7D0" modified="2013-07-24" version="1">MTEGISLDGRTLVGVANDDAGEVSDETTFTVEQTGDRISARYAGGSIVEGHLLGTIDDGEWDVRYVQLHENGETATGHSVGEISVLEDGRVRIDDEWEWDRRTAKVNPCSKKSGSDLSAEIRRRCGGARSCAAKPRRRARDEQRNERSDVSSAGGWGGLRCCCGAGLRKGPCGRRSPGEGEPSGARRTNKHRRPKAEERSEPRVTERSGAFGEHDAETNTHKRLPRSSVHVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA16</accession>
    <name>R4WA16_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpl2p</name>
        <name evidence="4" type="synonym">rpl2</name>
        <name evidence="7" type="ORF">L593_11120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447063.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11120"/>
    <dbReference type="EnsemblBacteria" id="AGN02169">
        <property type="protein sequence ID" value="AGN02169"/>
        <property type="gene ID" value="L593_11120"/>
    </dbReference>
    <dbReference type="GeneID" id="16180795"/>
    <dbReference type="KEGG" id="sali:L593_11120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2294"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_2"/>
    <dbReference type="OrthoDB" id="74812at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="240" mass="25509" checksum="C2C648ABFAB12E73" modified="2013-07-24" version="1">MGRRIRGQRRGRGGSVFRAPSHRYKSDKQHKKNEDDDLVSGEVVDIEHDPARSAPIAQVQFEDGDQRLVLAPEGVGVGDQIQVGISASIEPGNTLPLAEIPEGVPVCNVESNPGDGGTFARASGVSARVVTHDRSVTVVQLPSGEVKRLDPDCRATIGVVAGGGRTEKPMVKAGNKYHKVKSRAMTWPRVRGVAMNAVDHPFGGGGRQHPGRPKSVSRDAPPGRKVGDIASRRTGRGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA20</accession>
    <name>R4WA20_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secY</name>
        <name evidence="15" type="ORF">L593_11220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447083.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11220"/>
    <dbReference type="EnsemblBacteria" id="AGN02189">
        <property type="protein sequence ID" value="AGN02189"/>
        <property type="gene ID" value="L593_11220"/>
    </dbReference>
    <dbReference type="GeneID" id="16180559"/>
    <dbReference type="KEGG" id="sali:L593_11220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2314"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OrthoDB" id="13531at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="253"/>
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        </location>
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            <begin position="38"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN02189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="480" mass="51852" checksum="485ABE9A37E84565" modified="2013-07-24" version="1">MGWKEVAEPVLARMPVVRRPESHVPFKRKLAWTASVLVLYFFLTNVALWGMSTNTDAFGQFRTVLAGSQGSILQVGIGPIVTASIVLQLLGGANLLGLDTDDPRDQILYQGLQKLLVVIVTILTALPMVYAGFIQASPQVASQLGVSLAGIRILLMAQIVTGGLLILYLDEIVSKWGVGSGVGLFIIAGVSQRLVGGFLSLEGGFFVTWFKIFTGDIAVGPIPGVGLETIIVGEGQLLALATTLFIFVVVVYAESVRVEIPLSHARVKGARGRFPVKLIYASVLPMILVRALQANIQFLGQLLNREGISPDWLGVYTQSGDPIGGLMYYLAPIYTPQDWMWFTGQTPAGIETWQIMIRVAIDLGFMIGGGAIFAIFWVETTDMGPEATAKQIQNSGMQIPGFRQDVGVVEKVMERYIPQVTIIGGALVGLLAVMANMLGAIGGVSGTGLLLTVSITYKLYEEIAEEQLMEMHPMMRQMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA53</accession>
    <name>R4WA53_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_12055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2480"/>
    <dbReference type="eggNOG" id="arCOG04418">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134817_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018716">
        <property type="entry name" value="DUF2240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09999">
        <property type="entry name" value="DUF2240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16429" checksum="F73884CE3083CC93" modified="2013-07-24" version="1">MDLRRTVAAPFRQRGVEELGESEFVAAIAMDRRWYSPAQAKRLLDVADGEGLIDRSDDAVAPTFDVGETSIPEEFSPGEDLLRDRSAFERVLDVLTDAGHEKREAVAGINQLQSDLGVTIEAAAVVYARRQGEPVTDVAERARSELAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA61</accession>
    <name>R4WA61_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
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        <name evidence="1" type="ORF">L593_12265</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN02394">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2523"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="35079" checksum="4F69CAB934FDE1FE" modified="2013-07-24" version="1">MALPLLDANGWSLDDVPDQSGRTVVVTGANSGLGYHATRAFARKGADVVMACRSLERGERARDDLADAVPADRLAVERLDLADLESVQSFVERFEADHTELHVLCNNAGIMAIPRRETADGFEYQFGVNHLGHFALTGGLLDRLRATEGETRVVTQSSGLHANGEIQFDDLQFEDEYGEWTAYAQSKLANVLFAYELDRRLDAAGSDVASLACHPGYADTNLQRRGPELRGSRLRLWGMQAANALFAQSARRGALPMLYAATSPELTGGEYVGPGGIANLRGAPEVQASSDRSYDEALARRLWPVSEELTGVEYEFGDAVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA67</accession>
    <name>R4WA67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_12425</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12425"/>
    <dbReference type="EnsemblBacteria" id="AGN02424">
        <property type="protein sequence ID" value="AGN02424"/>
        <property type="gene ID" value="L593_12425"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12425"/>
    <dbReference type="eggNOG" id="arCOG04662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="480" mass="50680" checksum="C04CD51CA3C15994" modified="2013-07-24" version="1">MVDFRAILADRSVNAAVAWLSTVVLVLASATLFAAREWLWLVFVGLVLGVVLLSPLLARDVTTTLPGELVALVTIPIVVRATGTFLQATPFVTLAGLALLVVLLLDAFTSLEMAPRFAVLFVVITTMAFAGIWAMGEFAADLFLGTEFIGGQRALNISLVTATVVGAVAGVVFGVYFRETGGDSPLSRTPLGIPFRRVRSQEDGGGDADGSDLDDGIDPTVGVVPEVPDRQTEDTADPATSDESDPSDVDESDPDAAEESDPSDVVEEADPSDGVTEAPKYRWAIRALQLVLVAIVGYSIVTVQATLFVNSAVPLALTLLPVVARRRYGYPMHAGLALLISLAATLHAVGALGPYQTTDWYDTVTHALSSTLVAGVGYVIARGIELHTDKVSFSPRFRGAFIVLFVLAVGVLWEILEFASGIGAGLFGAEVLAQYGVSDIVKDLTFNSVGAIAVALWGTGLFRRPARMLSGSVGQLFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA0</accession>
    <name>R4WAA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_13250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447483.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13250"/>
    <dbReference type="EnsemblBacteria" id="AGN02589">
        <property type="protein sequence ID" value="AGN02589"/>
        <property type="gene ID" value="L593_13250"/>
    </dbReference>
    <dbReference type="GeneID" id="16180487"/>
    <dbReference type="KEGG" id="sali:L593_13250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2711"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
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    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="4">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="6">
        <location>
            <begin position="506"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="68678" checksum="AEA3CA7ED1FDA11F" modified="2013-07-24" version="1">MTDDELIWRVAGGSGDGIDSTSQNFAKALMRSGLNVFTHRHYPSRIRGGHTYVEIRAADEEVASRGDGYNFLLALGDSFARNPDEDAYYGNEEVKPLKENLDELREGGIIVYDEGLLDEDDVEDLNERAEEEGWHVYPIDLRGMAREVGREVMRNTAGVGATAALLDMDLDEVENLMEDAMSGDILEQNLEILETAHDHVKEEFEHTHDLEVPTGTNEEEQVLLSGSNGVAYGALDAGCRFIAGYPMTPWTDVFTIMSQNLPDFGGISEQVEDEIAAAALAVGASHAGVKSMSGSSGGGFALMSEPLGLAEMTETPLVLIEAMRAGPSTGMPTKPEQGDLEHILYTSQGDSNRVVFAPGNIKECYEQTRTAFQIAYDYQIPVMVIIDQKLSGENRNVPESFFDRQPDPDPGAVLTEEEIAEAAHDPSGKFNRFLHETEKGVSPRSLPGQKGGHYLATGNEHNMAGHISEDPENRVAQMDRRMQKLESIREELDEESNQTTRGPEDADFGILTWGSSQGTVLEATDRLNEAGHDVKTLSVSEMMPLPAEDIAAFLESVDEAMVVEMNATAQFRGLIQKELGRFGPKLTSLLKYNGNPFEPAEVVEGYHAQQDGEGDTPGTNTTIQPAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD2</accession>
    <name>R4WAD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Halocyanin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447643.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14050"/>
    <dbReference type="EnsemblBacteria" id="AGN02749">
        <property type="protein sequence ID" value="AGN02749"/>
        <property type="gene ID" value="L593_14050"/>
    </dbReference>
    <dbReference type="GeneID" id="16181035"/>
    <dbReference type="KEGG" id="sali:L593_14050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2875"/>
    <dbReference type="eggNOG" id="arCOG02921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_2_2"/>
    <dbReference type="OrthoDB" id="111620at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017533">
        <property type="entry name" value="Halocyanin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03102">
        <property type="entry name" value="halo_cynanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="24016" checksum="710A8784E1281563" modified="2013-07-24" version="1">MEHPSRRRFLYGSALAIGVGVSGCVGGDDDGNDTEEDGGADATDGGMEDGEDGDGANMTDGDEETDGGGETDDGDETDGGNETTDGDDETDGDGETGGAPSIEDYPVVEEWLTETELGGADDSWDGTLADETGTDTVTVAVGADGNGGSFAYGPSAVAISVGTTVEWDWTGEGNPHNVEALPAEQLGESDFEFSSGEATGGSGVQYTRAFEETGVALYHCEPHFSLGMKGAIVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD6</accession>
    <name>R4WAD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447663.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14150"/>
    <dbReference type="EnsemblBacteria" id="AGN02769">
        <property type="protein sequence ID" value="AGN02769"/>
        <property type="gene ID" value="L593_14150"/>
    </dbReference>
    <dbReference type="GeneID" id="16181085"/>
    <dbReference type="KEGG" id="sali:L593_14150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2895"/>
    <dbReference type="eggNOG" id="arCOG00474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031500_2_0_2"/>
    <dbReference type="OrthoDB" id="88805at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="25792" checksum="726EB11C24A5437A" modified="2013-07-24" version="1">MSKQSIRDAIWDALEDEGIARFPFPPHDRIPNFAGASEAAQRLSETDEWAAADVVKANPDAPQLPVRRRALRAGKTVYVAVPRLADEQPFRALDPEHIAAIDGASIDDATTISGIDEYGEPVGPEAVPHVDLIVSGSVAVSTDGTRIGKGEGYSDLEFAVLSELGAVDESTTVVTTVHDRQVLDDLPDPGDHDVPLDLLVTPERTIRTERSGARPEGVDWPLLDPDRIAEIPVLQQLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE4</accession>
    <name>R4WAE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14350"/>
    <dbReference type="EnsemblBacteria" id="AGN02809">
        <property type="protein sequence ID" value="AGN02809"/>
        <property type="gene ID" value="L593_14350"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14350"/>
    <dbReference type="eggNOG" id="arCOG02998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126380_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="183" mass="19359" checksum="15EF64CE2C2F46C2" modified="2013-07-24" version="1">MNRVAIDDLESGPTAGTAARHDLSEALVSRHVAINHYVVAPGERISGLHAHGDQEECFLVLDGTATIETLDGEVELDADEAIRFEPGEYQSVTNDAARELALLAIGAPPESEDVRIPLSCPDCDYEYREPALLDSGPALICPDCGFEEPATCPACGGEDLYAALGHHEEPVSVCADCGTATEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF1</accession>
    <name>R4WAF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447738.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14525"/>
    <dbReference type="EnsemblBacteria" id="AGN02844">
        <property type="protein sequence ID" value="AGN02844"/>
        <property type="gene ID" value="L593_14525"/>
    </dbReference>
    <dbReference type="GeneID" id="16181159"/>
    <dbReference type="KEGG" id="sali:L593_14525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2970"/>
    <dbReference type="eggNOG" id="arCOG00314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_2"/>
    <dbReference type="OrthoDB" id="76450at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="21269" checksum="BC133E0A38029B62" modified="2013-07-24" version="1">MAGESIDRLETGDSAPSFELPGTDGRTYSLDSFDDATAVLVVFTCNHCPYAQAKHPLLNDLAAEYDDVSVVGINPNDPDAYPEDSFESMQEAVESGEVAYDAYLFDESQSVAASYGAVCTPDPFLFDNGDGEFQLAYHAQLDDALNPDDEATRVHIREAIDAVRGGDPVDVDGQPSRGCTIKWRDGNEPEYWDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF7</accession>
    <name>R4WAF7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="11" type="ORF">L593_14700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447768.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14700"/>
    <dbReference type="EnsemblBacteria" id="AGN02874">
        <property type="protein sequence ID" value="AGN02874"/>
        <property type="gene ID" value="L593_14700"/>
    </dbReference>
    <dbReference type="GeneID" id="16181418"/>
    <dbReference type="KEGG" id="sali:L593_14700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3001"/>
    <dbReference type="eggNOG" id="arCOG04487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_2"/>
    <dbReference type="OrthoDB" id="2839at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="10">
        <location>
            <begin position="111"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-77)" evidence="8">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="712" mass="79140" checksum="7E28E18D9C4E2438" modified="2013-07-24" version="1">MNGSDQDWWPNQLKVAILDQNARDVDPWGDEFDYAEAFESLDLDAVKADIEDVMTTSQDWWPADYGHYGPLFIRMAWHSAGTYRTTDGRGGASEGAQRFAPLNSWPDNANLDKARRLLQPVKQKYGRKLSWADLLILAGNVAIESMGGETFGFAGGREDAFAPDEAVYWGPENEMEASDRFTDDGELEEPLGATVMGLIYVNPEGPDGQPDPEASAENIRESFDRMAMNDEETVALIAGGHTFGKVHGADSSEHLGPEPEAAPIEEQGLGWKNEYGSGKGGDTITSGIEGPWTQAPIEWDLGYLDNLLDYEWEPHEGPGGAWQWKPVDEELEDSVPDAHDESEQTTPMMLTTDIALKKDPDYREIVERFQDNPMEFGINFAKAWYKLTHRDMGPPSRFHGPEVPEEEMIWQDPLPVADYDLIDDAAAADLKGQLLESDLSISQLVKTAWASASTFRSSDKRGGANGARIRLEPQRSWAVNEPEELDAVLETYEEIQASFNESRSDDTRVSLADLIVLGGHAAVEQAAANAGHDVTVPFEPGRTDATQDQTDVESFEALEPKADGFRNYLGEETDRPAEEHLIDKADLLDLTPAEMTVLVGGMRALNANYQGSELGVFTEQPEALTNDFFVNLLDMSVEWEPVSDDENVFEGRDRETGEREWKGSRVDLIFGSHSRLRAIADVYASDDAEEKFVEDFVDAWTKVMTADRFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS49</accession>
    <name>R4VS49_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating</fullName>
            <shortName evidence="3">6PGDH</shortName>
            <ecNumber evidence="3">1.1.1.343</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH</text>
            <dbReference type="Rhea" id="RHEA:33023"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.343"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.343" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444939.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00450"/>
    <dbReference type="EnsemblBacteria" id="AGN00045">
        <property type="protein sequence ID" value="AGN00045"/>
        <property type="gene ID" value="L593_00450"/>
    </dbReference>
    <dbReference type="GeneID" id="16182085"/>
    <dbReference type="KEGG" id="sali:L593_00450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.92"/>
    <dbReference type="eggNOG" id="arCOG00248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_2"/>
    <dbReference type="OrthoDB" id="30530at2157"/>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02047">
        <property type="entry name" value="6PGDH_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032883">
        <property type="entry name" value="6PGDH_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="165"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="31853" checksum="0291C74FF339A73A" modified="2013-07-24" version="1">MHIGVIGLGRMGRIVVDRLLDAGHDVVAFDIDDDAVAAAADAGVTPADSIPDVADELGSERRIWLMVPAGDPVDAALAELDGHVDGDDVIVDGGNSHFEASVRRADATDAAYLDCGTSGGPAGAELGFSLMIGGPEWAYEAMVPAFDAVATGPDGHDRMGPVGSGHYVKMVHNGIEYALMQAYGEGFELLARGRYDLDLESVARTWTNGAVIRSWLLDLCEEAFREEGSDLGDVADHVQGGSTGTWTVQEALEQEVPVPLIYQALAERFDSRKDRFARKLANRLRYGFGRHEVVREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT09</accession>
    <name>R4VT09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445224.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01895"/>
    <dbReference type="EnsemblBacteria" id="AGN00330">
        <property type="protein sequence ID" value="AGN00330"/>
        <property type="gene ID" value="L593_01895"/>
    </dbReference>
    <dbReference type="GeneID" id="16179979"/>
    <dbReference type="KEGG" id="sali:L593_01895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.385"/>
    <dbReference type="eggNOG" id="arCOG02761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126998_1_1_2"/>
    <dbReference type="OrthoDB" id="98045at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="16432" checksum="19667A584D8454F2" modified="2013-07-24" version="1">MSLPIDPSQIDPADYGEHQTVLEMDHDEAIEHVREVCLDVGFGVPVEFSPSELLNEKVDADRDPYYVLGACNPAVADRVLDVSKEMGGLFPCNMVIWEEAPGQQRVYHVSIMKIARLLGIVPDDDEMQAIVDDTGEMVAETFERLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT64</accession>
    <name>R4VT64_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rad50</name>
        <name evidence="12" type="ORF">L593_02220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445289.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02220"/>
    <dbReference type="EnsemblBacteria" id="AGN00395">
        <property type="protein sequence ID" value="AGN00395"/>
        <property type="gene ID" value="L593_02220"/>
    </dbReference>
    <dbReference type="GeneID" id="16180121"/>
    <dbReference type="KEGG" id="sali:L593_02220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.450"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_1_2"/>
    <dbReference type="OrthoDB" id="1771at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03240">
        <property type="entry name" value="ABC_Rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00449">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045171">
        <property type="entry name" value="ABC_Rad50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022982">
        <property type="entry name" value="Rad50_ATPase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="11">
        <location>
            <begin position="407"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="889" mass="100671" checksum="80EC85AE878C47D5" modified="2013-07-24" version="1">MRIQRVRLENVRCYGEADVDLESGVTVVHGPNGSGKTTLLEGAFFALYGARALDETLEDFVSTGADDAEVEVWFAHDGAEYRIERRVRATGERATTAKCVLETPEHTIEGARDVRASIADLLRMDAEAFVNCAYVRQGEVNKLIHATPSERQDTIDELLQLGALEEYRDRAGDARLAVEDALGEVRGEVSGIEEQIEEKEDADLHAQLNELETDLGEVEDEIDHVEAQIEQAEETKADAASVLEEFAEKREELAELREGIEEKEEQIAGTEETRDELQERLSECRNRREELSERRDELLAESEVDEAEAEAVEGALTAVEARDDELRDELEGQRLAIQELSSDAEDAEADADECEAEAEAKREQAAELEAEIEDDEATLAERRESVEDLEEQLGDLRARFEDAPVEQAGAEEHAAEIEGAIGDVEDQLADRRADREAVVDRIERGEELLEEGKCPECGQPVEDSPHVDALGEDRERREAIEEEIEELDERRETLAERLERAEELVDAAEEIDRLEERRDSVTELLSERETTIEDKRARVETLREDAEQLEADAQAARETAEAKREAVDDERQAIAELNQERQSLRDREERLDALLEAIEELADLADEMDSLRERRELLAEQNEERRETLRERRERVAEIEDAYDEDRIEEAREDKQRAESYLEDATEELEAKLERRDELQNQIGRVKAEIDELESLRERHESLAEERDALESLKAEAEELEATYGDLRAELRQRNVAHLERLLNETFELVYRNDAYDRIELSGDYELTVYQRDGEPLAPTQLSGGERALFNLSLRCAIYRLLAEGIEGSAPMPPLILDEPTVFLDSGHVGKLVELINAMTDLGVEQILVVSHDDELLDAADAHVRVRKDPSTNRATVDRGPLDLAALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUL4</accession>
    <name>R4VUL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445804.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04805"/>
    <dbReference type="EnsemblBacteria" id="AGN00910">
        <property type="protein sequence ID" value="AGN00910"/>
        <property type="gene ID" value="L593_04805"/>
    </dbReference>
    <dbReference type="GeneID" id="16181100"/>
    <dbReference type="KEGG" id="sali:L593_04805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.982"/>
    <dbReference type="eggNOG" id="arCOG04214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_1_2"/>
    <dbReference type="OrthoDB" id="85388at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="132" mass="14542" checksum="EAF0E541C23F1851" modified="2013-07-24" version="1">MQETIRVSTDDRLEAVPITDRVASWIPDDLDAGTCHVYARHTTTGVLLNENESRLRADVEELLVDLVPTDGYHHDELDGNADSHLRASLLGPDVTIPITDGDLALGTWQSILLVECDGPRERELVVTVTEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVP3</accession>
    <name>R4VVP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01270">
        <property type="protein sequence ID" value="AGN01270"/>
        <property type="gene ID" value="L593_06615"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06615"/>
    <dbReference type="HOGENOM" id="CLU_1691609_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="155" mass="17501" checksum="1A66F3CC5A578EA5" modified="2013-07-24" version="1">MEPPASDLLLEPSEVGEQWEEDTRRTTDGSNSGFDQENLHGITHWQFINGEDLFFKQIAVLFKEPELAADGYQLTRNSIEPAGEEYLNFQELSYGEEGIAALGAEPVANRANTLLLQGNLMVNVVVEPYDDSAEPQEQHFEMVLDYTEQLYNSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW40</accession>
    <name>R4VW40_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446329.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07450"/>
    <dbReference type="EnsemblBacteria" id="AGN01435">
        <property type="protein sequence ID" value="AGN01435"/>
        <property type="gene ID" value="L593_07450"/>
    </dbReference>
    <dbReference type="GeneID" id="16182126"/>
    <dbReference type="KEGG" id="sali:L593_07450"/>
    <dbReference type="eggNOG" id="arCOG08205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825432_0_0_2"/>
    <dbReference type="OrthoDB" id="43447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="35784" checksum="A247B25617E256B0" modified="2013-07-24" version="1">MSLGKAITPERTTLRKLGIVLLALALVAGAGCSGAVLGGDGGGSSDEALIEYVPQDQTIVMSFDMDVMQDQTTMELLASSENDEASQEDLQEGFSEFESETGLDPSGFNSMLIYGQDTGMSASVGDTSQEDVGILVDTDWSTEDLVSAIESNDSVSLQEQDYSESGVFYKLVDETSQSDEETYVGVHGNGVYVMGTEGPVRNSLDVTYGDGEALSGTLRDAYDDTRDGYMSFAMTMPEDTGTGGGMGSSMTQDIQAMTGVYYTSGDTVGLEGRIIMSNEQSAEQFSSTVQMVLTSYGQDPQMSQFVENLDVGQDGSDVTFTYESDVQTLIEASESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW60</accession>
    <name>R4VW60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445400.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02775"/>
    <dbReference type="EnsemblBacteria" id="AGN00506">
        <property type="protein sequence ID" value="AGN00506"/>
        <property type="gene ID" value="L593_02775"/>
    </dbReference>
    <dbReference type="GeneID" id="16180329"/>
    <dbReference type="KEGG" id="sali:L593_02775"/>
    <dbReference type="eggNOG" id="arCOG06420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134821_0_0_2"/>
    <dbReference type="OrthoDB" id="123023at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12166" checksum="3881D50DBD99EB3E" modified="2013-07-24" version="1">MTLAEVAIRAVGTFVVATVFYTLTVHLAATYVLEEASIFEALLVGPVPAAISVGLGLAAQSTVPAASAVAVPLVAIPADFLAIAWSYELDRRMAALVTLGHFVVSILLAASLIGLFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWE6</accession>
    <name>R4VWE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445500.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03275"/>
    <dbReference type="EnsemblBacteria" id="AGN00606">
        <property type="protein sequence ID" value="AGN00606"/>
        <property type="gene ID" value="L593_03275"/>
    </dbReference>
    <dbReference type="GeneID" id="16180481"/>
    <dbReference type="KEGG" id="sali:L593_03275"/>
    <dbReference type="eggNOG" id="arCOG04592">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433753_0_0_2"/>
    <dbReference type="OrthoDB" id="116698at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9799" checksum="F2A7FEDB3EA4BA43" modified="2013-07-24" version="1">MADEFIKGFGILSGAGMIWMILAGWYRTPSFGGRQLTAPVSPASNIYEQMAYLLMDAMFWFMILGPLTFWILIPVARELRAGYAGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWK6</accession>
    <name>R4VWK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446519.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08400"/>
    <dbReference type="EnsemblBacteria" id="AGN01625">
        <property type="protein sequence ID" value="AGN01625"/>
        <property type="gene ID" value="L593_08400"/>
    </dbReference>
    <dbReference type="GeneID" id="16182392"/>
    <dbReference type="KEGG" id="sali:L593_08400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1721"/>
    <dbReference type="eggNOG" id="arCOG03055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06378">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529176_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="185" mass="19333" checksum="B58CA913119140D8" modified="2013-07-24" version="1">MQSSRRQLLGTIGSGLALSLGGCLSSDDDGGNDTDATSSDATGTNGGSDQSVDGSDRSGDGSSESGDGEGSLVVRLVGPDEEYRLFDRSGVATVGEVTRGNEAPYVPVSLTEDRTATIVDLAQRVGLGDRHDAFEVVAVLDGEEIHRAQVGAELARDVQTGEWEGSFVVYARDAEEARRIRAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWX7</accession>
    <name>R4VWX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446604.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08825"/>
    <dbReference type="EnsemblBacteria" id="AGN01710">
        <property type="protein sequence ID" value="AGN01710"/>
        <property type="gene ID" value="L593_08825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181746"/>
    <dbReference type="KEGG" id="sali:L593_08825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1808"/>
    <dbReference type="eggNOG" id="arCOG00086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_2"/>
    <dbReference type="OrthoDB" id="100703at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23436" checksum="82C370499E136444" modified="2013-07-24" version="1">MSASDRGDRTATRRGDADATTTDEDRPLVLFVDNFDSFTYNLVEYVSEHADTEVVKNTASLAEIREIDPDAIVISPGPGHPKNERDVGVTIDVLTEISTEVPTLGVCLGLEAAVHAYGGTVGRAPEPIHGKAFPIDHDESGVFAGLEQGMRGGRYHSLVATAVPEDEFEITATADHDGEELVMGIRHREHPIEAVQFHPESVLTAAGHDVIENFLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWX9</accession>
    <name>R4VWX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04075"/>
    <dbReference type="EnsemblBacteria" id="AGN00766">
        <property type="protein sequence ID" value="AGN00766"/>
        <property type="gene ID" value="L593_04075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.828"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="410" mass="41669" checksum="13B6BC94AD88840C" modified="2013-07-24" version="1">MDVTDAVLLEGSGPFRLDYDPGAIRYGAGATASLSDDLAEMGFDRALVVTGTTIGETAAVMDPVSSGLGDRLAGVFAETTPEKRLSTAVAGAAAARERDADVLVAVGGGSSIDTAKAIATVRTRDDDPQALGAEFAERQTLTVPDDPLPIVAVPTTFAGADFTIGAGLSASPAAGDLVDAEVAGGLGGTQLGPVEAVYDPEVVATTPRSILAGSAMNGFDKAIETLYSRHATAITDATATRGVRRFREGLLAFGEAGSGDYHDGVPAAVEGLLLAQYGISRTDCTTMSVIHAAGQAVSARGDVQQGVAHAICAPHLLEHLLETAAVRIGLVANAFGVADGADPETSIVDELVAVRDALGVTTALRDVPGIDREDLPEIAAAVADHRFVANGPADYEPTAPSLEAVLDAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWY4</accession>
    <name>R4VWY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445665.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04100"/>
    <dbReference type="EnsemblBacteria" id="AGN00771">
        <property type="protein sequence ID" value="AGN00771"/>
        <property type="gene ID" value="L593_04100"/>
    </dbReference>
    <dbReference type="GeneID" id="16180820"/>
    <dbReference type="KEGG" id="sali:L593_04100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.833"/>
    <dbReference type="eggNOG" id="arCOG02546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_4_2"/>
    <dbReference type="OrthoDB" id="44682at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="325"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="714" mass="76224" checksum="8440EC6F50399976" modified="2013-07-24" version="1">MNESRRSILRKASALSALAVGASATASAADCSGVSEWDSTTAYNGGDQVTHDGDLFTAEWWTKGEEPDGSKSVWTNEGACDGSGGGGGSETDCSGVSAWDSSTAYNGGDQVTHDGQLWTAEWWTQGTEPAESEAVWTLEGACTTNEAPTASFTVSPSNPAPGESVTFDASGSSDPDGTISSYSWEFGDGTSGSGESTTHTYDAAQVVTVTLTVTDDGGETASTTQDVTIGDPNAAPTASFTNDPASPEPGQTATFDASGSGDSDGSIASYEWEFGDGTTATGQTVDHTFASEGTYSVTLTVTDDDGATGTTTTDVSVTTGPSDEFKVIGYYPGWKASSPYDYYPEDIPWDKVTDVQYAFLGVDASAGEPTIMSTRDEENLQTFKELKSGPASDTRVTLSIGGWEDSEGFSQIAGSSSKRQSFADRCVEILRQYDLDGIDIDWEHPGSSQGKCQCGSNEDYETHVDLLQAIRDALDAAGQEDGKQYHLSVANGGSDWNAGGLRHGEIGEVCDYTSIMAYDFTGSWMDQVGQNAPLYGTQHPLETTEYGTQYQNQYYVEYAVDKLYGGEHDETGYWPGQWEYPPAPPAEYNELVLGLPFYGRGFNGTEMYGSYSGLPEGTWHSALEDGADPTGAFDYGDIEENMEGASGWNKSRHDPGAVPYIVNESEETIISYDDAQSIAEKVSFAKERGMQGVMFWELSQDWNHTLLDAILAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX19</accession>
    <name>R4VX19_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl40e</name>
        <name evidence="6" type="ORF">L593_04300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445705.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04300"/>
    <dbReference type="EnsemblBacteria" id="AGN00811">
        <property type="protein sequence ID" value="AGN00811"/>
        <property type="gene ID" value="L593_04300"/>
    </dbReference>
    <dbReference type="GeneID" id="16181793"/>
    <dbReference type="KEGG" id="sali:L593_04300"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205640_0_0_2"/>
    <dbReference type="OrthoDB" id="127293at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00788">
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    </dbReference>
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        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L40e_arc"/>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="49" mass="5545" checksum="09A6228EECB0C66E" modified="2013-07-24" version="1">MPKFEAAEDRLLNKAICMRCNARNSPDADRCRKCGHGNLRPKARESRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXA3</accession>
    <name>R4VXA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446759.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09600"/>
    <dbReference type="EnsemblBacteria" id="AGN01865">
        <property type="protein sequence ID" value="AGN01865"/>
        <property type="gene ID" value="L593_09600"/>
    </dbReference>
    <dbReference type="GeneID" id="16179845"/>
    <dbReference type="KEGG" id="sali:L593_09600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1976"/>
    <dbReference type="eggNOG" id="arCOG10673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_0_1_2"/>
    <dbReference type="OrthoDB" id="108814at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="117" mass="12827" checksum="795022A310BD43BB" modified="2013-07-24" version="1">MADLAHVNFACADPADLADFWAAALDAERLDLLDDLGLEIVEVPYGPELMFREAPRGTDRDLPIHLDLHAEDRKAEVDRLEQLGAAVRETKTDEEHGTVWTVLEDPAGNGFCVSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXC1</accession>
    <name>R4VXC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445805.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04810"/>
    <dbReference type="EnsemblBacteria" id="AGN00911">
        <property type="protein sequence ID" value="AGN00911"/>
        <property type="gene ID" value="L593_04810"/>
    </dbReference>
    <dbReference type="GeneID" id="16181101"/>
    <dbReference type="KEGG" id="sali:L593_04810"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_2"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="452"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="540" mass="55959" checksum="17E927014D1D41E3" modified="2013-07-24" version="1">MRTPQGSDPVAERARVSADETALVRAADGSSWTYGHLDEAVERTAGKLATLDVERGDHVGLLAETGVPAVRTIYGALRLGAVPVPLNTRLTADELGPQLDTADVEVLVCERGTGALGVAAAKEAPREPPTTIATLDGDDTDADEAVRLGAQSADGFETTVPDPDDVRLLLFTSGTTGRPKAVELTAENLRSSAVASALRLGIDPDDHWFDPLAVYHMGGFAPIYRSICYGTTAILQREFDAAATLAAIDRTDSTCLSVVPTMLQRMLDAADEADGASANGTGAGSANGAGTGPAADPLADLRFVLSGGAATPPALVERCADLDVALCPTYGITETCSQVATALPAEARDHEGTVGRPLYPTTVTILGDDGVDEGPGEPLPAGESGEIVVDGPTVSPGYYGDETATAESRSDLGYHTGDLGRRDDAGRLWVLGRADDAISTGGELVHPAEVVEALEAHPTIDAAAVVGLDDPEWGERVAALLVPTDAEVSPGDLRDTGADRLAGYKRPKTVALADELPRTASGTVDRDAVRERLRADGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXG0</accession>
    <name>R4VXG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446829.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09950"/>
    <dbReference type="EnsemblBacteria" id="AGN01935">
        <property type="protein sequence ID" value="AGN01935"/>
        <property type="gene ID" value="L593_09950"/>
    </dbReference>
    <dbReference type="GeneID" id="16182866"/>
    <dbReference type="KEGG" id="sali:L593_09950"/>
    <dbReference type="HOGENOM" id="CLU_1623526_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="163" mass="15997" checksum="05F30B09B3C314EF" modified="2013-07-24" version="1">MTGRLAGACATLASTIALVLVGTGTWPTLLGGAGLALLLGGLVRRRIGAVTLGCTGSFAALLFATASDPGTAGGLGSWSVVAAGGAIVLAWTTGRTSVQLRTELPRANTTRLEATHVAGTTVLLGAACSIALLPGVITIYPSPLGLVLVAFGAIVLSAGLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXH3</accession>
    <name>R4VXH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446844.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10025"/>
    <dbReference type="EnsemblBacteria" id="AGN01950">
        <property type="protein sequence ID" value="AGN01950"/>
        <property type="gene ID" value="L593_10025"/>
    </dbReference>
    <dbReference type="GeneID" id="16180220"/>
    <dbReference type="KEGG" id="sali:L593_10025"/>
    <dbReference type="eggNOG" id="arCOG08970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110113_0_0_2"/>
    <dbReference type="OrthoDB" id="103986at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="21208" checksum="A72669CF5135A542" modified="2013-07-24" version="1">MVELTGVALILGGGVLLAFGAALSVYGVALLGAVLGGGAGYLVAPTIGGAIGLSGAVASLAAVAIGVVAGVLIAYTVLSMVVAIAGFAVGSLLGVYIVSDLAGVSGMLPKAGVALGTGILLAFLAMFLTKTALIGITAFLGASFASTQLTVGSFETAASDLTVDPLVVSLENPIFLGLFALGVLTQFGLFKLGWVGKIAGALPGASVIRDRGEQEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI6</accession>
    <name>R4VXI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10100"/>
    <dbReference type="EnsemblBacteria" id="AGN01965">
        <property type="protein sequence ID" value="AGN01965"/>
        <property type="gene ID" value="L593_10100"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2082"/>
    <dbReference type="eggNOG" id="arCOG02994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116722_4_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13571" checksum="7B2B178F40D7F4AA" modified="2013-07-24" version="1">MIRDRDSIEYESVDAAEGLQKGVLIDESRGAPTFALRRFTLDSGATVPRHTNDVEHVQYVLAGEYVVGLAGTEGEADLGDGEHRVRPGDSLLIPAGTVHWYRNDGDSTAAFLCGVPNGDDSIELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYE7</accession>
    <name>R4VYE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06495"/>
    <dbReference type="EnsemblBacteria" id="AGN01246">
        <property type="protein sequence ID" value="AGN01246"/>
        <property type="gene ID" value="L593_06495"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1324"/>
    <dbReference type="eggNOG" id="arCOG00260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="38448" checksum="ED844BCEA63DD4B1" modified="2013-07-24" version="1">MNALGRLRGVADRMATASGGERLLIGIGSVLLALFIGSIIVFAAGYDPITFLLFLFWGAFGSAGDVAFTLRKTTLLILAGVAVALAFRANIFNIGVQGQLVVGGFGTAMSIIWLAPYVPSGTLGGIVLMLIGIPIGMVCGGLYAAIPGVMKAYADANEVITTLMLNFIATGVLFVLVDGPLKDPDSPAPKTVDFPDSVEFPSVVLDSSRFSLYGLLIALAAVVVVSVVMNRTAFGYDLRTSGEQAEAAAYSGVIPERMIVSTMVFSGIVAGLCGAVYTIMVLGYYQDPGVTPTFGFDAIAVSLLAANNPIGVVPSSLLFGSLSSGKQFVEINQNVPQELVDGIVGLIVLFVATPELFRMAGRRRGDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYH9</accession>
    <name>R4VYH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447209.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11860"/>
    <dbReference type="EnsemblBacteria" id="AGN02315">
        <property type="protein sequence ID" value="AGN02315"/>
        <property type="gene ID" value="L593_11860"/>
    </dbReference>
    <dbReference type="GeneID" id="16180823"/>
    <dbReference type="KEGG" id="sali:L593_11860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2441"/>
    <dbReference type="eggNOG" id="arCOG02256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_2_2"/>
    <dbReference type="OrthoDB" id="38937at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="31466" checksum="020122F47D470B8D" modified="2013-07-24" version="1">MQTVRTLLVDAFTDEPLSGNAAGVVPDAAGLSEPQRQAIARELSVSETAFLANGDGADYRIQYFTPTQPVDLCGHATIGTFAGLAATDAIGAGTVEVETPVGVLEVTVEDDGSVWMTQDDPTIRRVDLDRERLAAALGLRPSAVTDLESELPLAVSSTGLPWLLVPVAFLSQLGDADPDLDAVAEIADEVDAVGIYPFTFDTLEREAHVHARAFAPGAGVPEDPVTGTASGATGAFLRHVGAFDGDLPEELLIEQGHYVERPGTVRVRAGEKIRVGGNGALALDGELRVPEMESDDILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYI4</accession>
    <name>R4VYI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447214.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11885"/>
    <dbReference type="EnsemblBacteria" id="AGN02320">
        <property type="protein sequence ID" value="AGN02320"/>
        <property type="gene ID" value="L593_11885"/>
    </dbReference>
    <dbReference type="GeneID" id="16181797"/>
    <dbReference type="KEGG" id="sali:L593_11885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2446"/>
    <dbReference type="eggNOG" id="arCOG01108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_2_1_2"/>
    <dbReference type="OrthoDB" id="32735at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="223"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="428" mass="45075" checksum="5B8B4C09CC75F343" modified="2013-07-24" version="1">MATATEIDRLVDLRRDLHRHPEPAWREFYTTARIVEACREIGVDDLHVGPDALASDARMAVPDDETLSEWSDRALEAGADEAIVSQLEGGHTGLIAELHRGEGPTVALRVDIDGLPRAESDDPEHVPAAEGFRSENEGAMHACGHDGHAAIGVGVLRAIAESDDFAGTLKVIFQPAEEQVGGAKAVAESGHLDDVDALLAIHLGLDHPTGEIVAGVEGFLAVAQVEAEFEGEPAHAGGRPEQGRNANQAMAAAIQNLYAIPRHSDGPTRVNAGIAEGGTASNVIPEYARLVVEVRGETTPLMEYVDDRARSVLEGAATMHECDLTISEDGRAPSATSDDELRDVVGAVAKGHADVERVLDRDDLAGSEDATYLMQAVQDNGGLAAYVGVGTDHPGGHHTATFDVDEDSIGIGVDVLSESIERIAADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYR6</accession>
    <name>R4VYR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylmercury lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447299.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12330"/>
    <dbReference type="EnsemblBacteria" id="AGN02405">
        <property type="protein sequence ID" value="AGN02405"/>
        <property type="gene ID" value="L593_12330"/>
    </dbReference>
    <dbReference type="GeneID" id="16179906"/>
    <dbReference type="KEGG" id="sali:L593_12330"/>
    <dbReference type="eggNOG" id="ENOG502N61K">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116127_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018836">
        <property type="term" value="F:alkylmercury lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046413">
        <property type="term" value="P:organomercury catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004927">
        <property type="entry name" value="MerB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03243">
        <property type="entry name" value="MerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="21426" checksum="683F5FE4121FE5A6" modified="2013-07-24" version="1">MAIDTADATTGIDPSTVELPDALGERFQRAFDLDRQPTSYGGWARAIAETFEAERDRSISTDDLCDTEASPHTATLDGETTHYVCVQDPIVVGLLADDPVTVESTPPTSDETVTIEFDGDGVTAVEPEGSLLSFGIAADVQAPPEITPEAMYGLVCPYGHAFPDDASYDEWAGETDAVTDVLSVSAGVSAMAALVEAAGMEGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ40</accession>
    <name>R4VZ40_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447429.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12980"/>
    <dbReference type="EnsemblBacteria" id="AGN02535">
        <property type="protein sequence ID" value="AGN02535"/>
        <property type="gene ID" value="L593_12980"/>
    </dbReference>
    <dbReference type="GeneID" id="16182504"/>
    <dbReference type="KEGG" id="sali:L593_12980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2661"/>
    <dbReference type="eggNOG" id="arCOG03130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073770_0_0_2"/>
    <dbReference type="OrthoDB" id="61485at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="86"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="28676" checksum="CE7961CB2B747BAA" modified="2013-07-24" version="1">MRIENSFVPVEGVGDVTERKLWRAGVTEWAEFEGQVVGPTRADRIESFVEEAERRLERGDAHFFADRVPDAEHWRLFENVREETTFLDIETTGLDQYTDRVTTVSIHRDGDTKTLVRGHDLAAETLRAELTESSLLVTFNGRRFDVPFLETSFDLSIDLPHADLMSMCNTLGYSGGLSAVEGRFGIERDRPDISGRDAVRLWHEYERGKDGSLETLIEYNQEDTVNMEPIMERACEELHEEVFEAARRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZB3</accession>
    <name>R4VZB3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1333523.L593_13380"/>
    <dbReference type="EnsemblBacteria" id="AGN02615">
        <property type="protein sequence ID" value="AGN02615"/>
        <property type="gene ID" value="L593_13380"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2737"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="41018" checksum="E5901A0C8864E111" modified="2013-07-24" version="1">MDYSDRVQRVEPSATVAVSNLASQLEADGVDVVDLSVGEPDFPTPEPIVDAGKTAMDEGHTGYTPSNGIPALREAIAAKLADDGLDYDPSEIVVTPGGKQSLYEIFQTILDDGEEVVLLDPAWVSYEAMAKLAGAEPTRVDLSQYDFQLEPGLDDLAEAVSDETELLVINSPSNPTGAVFSDAALEGVRDLAVEHDITVVSDEIYKEITYGTDATSLGTLDGMGDRTITVNGFSKAYSMTGWRLGYYAASEELVEQSGKLHSHSVTCATNFVQHAGVTALEEVEEEIVEMTDAFEERRDFLVEAFAERGVEVPEPEGAFYMMLPVDEDDQAWCENALEDAHVAMVPGSAFGTPGYARISYAASLDRLEEAVERLDDAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZD9</accession>
    <name>R4VZD9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446515.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08380"/>
    <dbReference type="EnsemblBacteria" id="AGN01621">
        <property type="protein sequence ID" value="AGN01621"/>
        <property type="gene ID" value="L593_08380"/>
    </dbReference>
    <dbReference type="GeneID" id="16182385"/>
    <dbReference type="KEGG" id="sali:L593_08380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1717"/>
    <dbReference type="eggNOG" id="arCOG04212">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_2_0_2"/>
    <dbReference type="OrthoDB" id="124564at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15729" checksum="89DD671C550DFF43" modified="2013-07-24" version="1">MDYRAVETTDEYVARLSTGADWRAEIEALAEEVEADAGWFTALGSVRDAEMWFYDQEKKEYEPVYFDEHLEVAACVGNVSILDGERFAHTHAVLSRPDGTALAGHLDSAEVFAGEVHFRKFAEPLERAHHEPTDLDLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZG2</accession>
    <name>R4VZG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446535.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08480"/>
    <dbReference type="EnsemblBacteria" id="AGN01641">
        <property type="protein sequence ID" value="AGN01641"/>
        <property type="gene ID" value="L593_08480"/>
    </dbReference>
    <dbReference type="GeneID" id="16182430"/>
    <dbReference type="KEGG" id="sali:L593_08480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1737"/>
    <dbReference type="eggNOG" id="arCOG06181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090892_1_0_2"/>
    <dbReference type="OrthoDB" id="87728at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="18345" checksum="D95271BEA63FB1DD" modified="2013-07-24" version="1">MRRRQALAAVAGLGLTGGSAWIAKNGIPGRESTASRLPITVETLDARGSSAGETPVPIPGSVTVVDLFATWCPPCDEQLAILDDVRSSYPSVEFVSVTNERPSDALTREDIAAWWNDHDGNWTLGLDPGSDLLAAFGASGLPYVAIADADGSIRFQDGGLVEAGPLRRELDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZN2</accession>
    <name>R4VZN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447594.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13805"/>
    <dbReference type="EnsemblBacteria" id="AGN02700">
        <property type="protein sequence ID" value="AGN02700"/>
        <property type="gene ID" value="L593_13805"/>
    </dbReference>
    <dbReference type="GeneID" id="16180849"/>
    <dbReference type="KEGG" id="sali:L593_13805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2825"/>
    <dbReference type="eggNOG" id="arCOG03063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150429_0_0_2"/>
    <dbReference type="OrthoDB" id="95686at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15435" checksum="6BF2ADF8ABF7A32B" modified="2013-07-24" version="1">MDGSTDMTLAFELSALEELAEPDAAFGNARRWSEYVGVVSAEPTYVVTNYTRKHRIRQDFFSGPRGKAESLESVREQFDTERHVFVGTSEEDRELADAEGWEYLSVEDAADAAGWTLAEDAPEADAAPVEEPERDDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW0</accession>
    <name>R4VZW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447684.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14255"/>
    <dbReference type="EnsemblBacteria" id="AGN02790">
        <property type="protein sequence ID" value="AGN02790"/>
        <property type="gene ID" value="L593_14255"/>
    </dbReference>
    <dbReference type="GeneID" id="16180145"/>
    <dbReference type="KEGG" id="sali:L593_14255"/>
    <dbReference type="eggNOG" id="arCOG07556">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113590_0_0_2"/>
    <dbReference type="OrthoDB" id="119641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="190" mass="20699" checksum="26A6E4D8E9A3582F" modified="2013-07-24" version="1">MSGDDGGEEDVEEAGDDGTEQPGEESPMDEFGLRGGDLTDRAGDPTAEPDDPEGDGSASGAASDDPPGSGGADADAPLSSLAASVDERRDRAVDPAEDELFDEEDVPEIDTEVVWDRLDEDEPPELPEETQQDVRVVEKRSYCEQCPFFSAPPDVRCTHDGTEILELVDMERFRVVDCPKVREDERLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W004</accession>
    <name>R4W004_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">L593_09305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446700.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09305"/>
    <dbReference type="EnsemblBacteria" id="AGN01806">
        <property type="protein sequence ID" value="AGN01806"/>
        <property type="gene ID" value="L593_09305"/>
    </dbReference>
    <dbReference type="GeneID" id="16182676"/>
    <dbReference type="KEGG" id="sali:L593_09305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1911"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_0_2"/>
    <dbReference type="OrthoDB" id="35979at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="36147" checksum="7E8DF92577DA98AD" modified="2013-07-24" version="1">MTRSTRQRERETEQSSEEETVRECPECGSEDLVKSSDRGELVCDDCGLVVEEEQIDPGPEWRAFNHQERQEKSRVGAPTTQTMHDKGLTTTIDWKDKDAYGRSISSKKRSQMHRLRKWQERIRTKDAGERNLQFALSEIDRMASALGVPRSVREVASVIYRRALKEDLIRGRSIEGVATAALYAACRKEGIPRSLEEISEVSRVERKEIGRTYRYISQELGLEMKPVDPKKYVPRFCSELELSEEVQSKANEIIEKTAEEGLLSGKSPTGYAAAAIYAASLLCNEKKTQREVADVAQVTEVTIRNRYQEQIEAMGIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0A9</accession>
    <name>R4W0A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447844.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15080"/>
    <dbReference type="EnsemblBacteria" id="AGN02950">
        <property type="protein sequence ID" value="AGN02950"/>
        <property type="gene ID" value="L593_15080"/>
    </dbReference>
    <dbReference type="GeneID" id="16181719"/>
    <dbReference type="KEGG" id="sali:L593_15080"/>
    <dbReference type="eggNOG" id="arCOG08172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090552_1_0_2"/>
    <dbReference type="OrthoDB" id="106596at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="188" mass="19493" checksum="F67F29FF6D8AC936" modified="2013-07-24" version="1">MVDWSERVEQLLFEGEHVETTVQVGAGTVVVTGQRVLVFTPEGDGKQFRAIDRPNVLGVERRGVSPLELVPTAGKLGVAGGLLVLVGVVLDPAALFPRPDLSSAQAAGGILGPVNSMLDLFYAIDTVAIALGALLAILGTALVGVQVATRQDRLAIEVAGEDDVLLSLGADDARLADLRQAIDAPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0F7</accession>
    <name>R4W0F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10230"/>
    <dbReference type="EnsemblBacteria" id="AGN01991">
        <property type="protein sequence ID" value="AGN01991"/>
        <property type="gene ID" value="L593_10230"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10230"/>
    <dbReference type="eggNOG" id="arCOG06240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132453_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043860">
        <property type="entry name" value="DUF5822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19139">
        <property type="entry name" value="DUF5822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="84" mass="9223" checksum="1735760D45308B5B" modified="2013-07-24" version="1">MQPASVPEPVETTDPDGVDFGRVMQLTFVYTIVIGAPLVALVSIPFSLPTWGDRATFAIRIGAIVWFVTSIAVYLLERRRVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1F0</accession>
    <name>R4W1F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_12435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447320.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12435"/>
    <dbReference type="EnsemblBacteria" id="AGN02426">
        <property type="protein sequence ID" value="AGN02426"/>
        <property type="gene ID" value="L593_12435"/>
    </dbReference>
    <dbReference type="GeneID" id="16182079"/>
    <dbReference type="KEGG" id="sali:L593_12435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2557"/>
    <dbReference type="eggNOG" id="arCOG04100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_1_0_2"/>
    <dbReference type="OrthoDB" id="11292at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="9">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="332"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="642" mass="70841" checksum="9D16F7819463A8FC" modified="2013-07-24" version="1">MDEGFDYGQFDRGRHMNYWTYDRTLQRELRRVYDAGEYEWAEPRLSEFGHLIGHTVADNADYIDDHGPELDTYDRFGEVQNFVRYPAEQFENEQAVYEAGIVADAFEAPPGRDEPMPISHYLGMLQLLSYAEGGGFGCPVAMTAGAALVLEKFDDGELEPYYDALVSRDYDDLIEGAMFLTEEQGGSDVGAIETTASDDEEVDCWRLAGEKWFCSNIDAEGTLALARTEDAPEGTAGLSMFLVPHGDPVGDPAAHIDADQDADAGGGPGGTSWQGDVLTKGARNDFDGAPPPEALNDQLYRRLKDKLGTIAVPTGEVEFDDTAAFLVGEEENGFKQMAEMLNLERLSNAAAACGVMGRSLLESKIRAADREAFGQPIDEYPLMREDLVDMAVDYEATTAFTHEAGRLLSERERAERAGEGDTDDAQHAYRLLRLLTPIAKLRTARMAIDTASYAMEIQGGNGYVNDFVTHRLLRDAQVLPIWEGTENVLSLDVLRALDREDAHEPLFDVMQRRLNAVSSDELADAAATVEAEYHDLAEALATVASEDEAYAQLSAKRLAHYVFEVFTAALLLEEADRALDDGDGRMALVARRFVDRELRDPDARGITSRDRFPIEHFEAIVQYESVAPERIDATGAVGESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W283</accession>
    <name>R4W283_9EURY</name>
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        <submittedName>
            <fullName evidence="2">PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447650.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14085"/>
    <dbReference type="EnsemblBacteria" id="AGN02756">
        <property type="protein sequence ID" value="AGN02756"/>
        <property type="gene ID" value="L593_14085"/>
    </dbReference>
    <dbReference type="GeneID" id="16181071"/>
    <dbReference type="KEGG" id="sali:L593_14085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2882"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_2"/>
    <dbReference type="OrthoDB" id="36944at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="33634" checksum="842CC43DB36F3548" modified="2013-07-24" version="1">MAELVTLGETMLRLSPPTGERLETATRLECRTAGAESNVAIAASRLGTDAAWLSKLPESPLGRRVVGDVQRHGVDPLIAWSEDGRQGTYYLEQGGEPRATDVIYDRADAAITSATTGDLAVEAVEDAELFFTTGITPALSDTCFETTRQLLEVADRTAFDLNYRSKLWSDSEAASAYEALLRDVDVLFAPERDVESILGIDGQPRTVAETLRDRFGCETVVLTRGEHGALARTPAGTVEQPAIDADTLDPIGTGDAFVGGYLSRILDGEAVERALAYGAATAALKRTITGDLAVVTERAVERVLDDRTTDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2M0</accession>
    <name>R4W2M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uvrC</name>
        <name evidence="9" type="ORF">L593_15085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447845.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15085"/>
    <dbReference type="EnsemblBacteria" id="AGN02951">
        <property type="protein sequence ID" value="AGN02951"/>
        <property type="gene ID" value="L593_15085"/>
    </dbReference>
    <dbReference type="GeneID" id="16181720"/>
    <dbReference type="KEGG" id="sali:L593_15085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3081"/>
    <dbReference type="eggNOG" id="arCOG00873">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_1_2"/>
    <dbReference type="OrthoDB" id="5341at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="275"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="607" mass="65732" checksum="5C8C87D42D997A83" modified="2013-07-24" version="1">MDAAGVRELAADLPRQPGVYQFRATGSREPTADEVAGNGGTGPERVLYVGKAVDLRDRVRSYADPRGQRIANMVAAADDVEIAVTDTETQALLLEANLIKRHQPRYNVRLTDDKSYPLVQFTEHEMPRIEITRDPDEGATVYGPFTDRGELETIVKAIRELYGLRGCSDHKYSGRDRPCLDYEIGLCTAPCTGEISPEAYGEDVLAARRFFEGETGALADPLRQRMGAAAQERAFERAASLRDRLETVEGFHGAGEDVVSHAGQQSGDHGVRTHVLGAAVEGREPTVAVLESEGGKLVDRHRPPLAVPESARDDPASLLAAFVPQYYADRRLPDVLLLPEDPADAEVRAWLEDRDVDVRVPGAGREARLVDLALKNARRAGPGRDPCVALADALGIDSANRVEGFDVSHAGGKATVGSNVLAVDGAEHTDGYRRKKLPEGNDDPGSMYELLRWRAERAVAGRDDRPDPDLLLIDGGDDQLDAATRAIGEAGWDVPLVAIAKGERGDRDADGDRILGADGPIDVPDEAMRLCQRVRDEAHRFAVQYHQTVRDDVTTALDAIDGVGPTTREALLGRFGSIESVRDASESELLDVEGVGPTTASTLQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2T4</accession>
    <name>R4W2T4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="12" type="ORF">L593_00910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445031.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00910"/>
    <dbReference type="EnsemblBacteria" id="AGN00137">
        <property type="protein sequence ID" value="AGN00137"/>
        <property type="gene ID" value="L593_00910"/>
    </dbReference>
    <dbReference type="GeneID" id="16182007"/>
    <dbReference type="KEGG" id="sali:L593_00910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.187"/>
    <dbReference type="eggNOG" id="arCOG04387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_2_2"/>
    <dbReference type="OrthoDB" id="35648at2157"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="339"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="371"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="456"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="472" mass="50634" checksum="C0768B886EB8D155" modified="2013-07-24" version="1">MTVTIVGAQLGDEGKGGIVDVFGESADVVARYQGGDNAGHTVVHGGETYKLSLVPSGAVRGKIGVLGNGCVVNPHTLFEELDGLHEQGLDPDVRVAERAHVIMPYHRILDNLEEDVRSDDDLKVGTTGRGIGPTYEDKVGRRGVRIGDLLDPAVLRDRLEYVIPQKRALIEDVYGIDLASVDLEFDGFSAEDALDVDAVYDRYVEYGERLRDEDMTVVAGEFLTSRIDDGEQVMLEGAQGTLLDIDHGNFPYVTSSNPTAGYAATGSGLGVTTIGDGEVVGVVKGYLSRVGTGPMPTELGPSDGGHGVDAGDEAAATGDDPSAEDLASYIREEGGEYGTVTGRPRRVGWLDLPMVRHAARASGFTGFAVNHVDVLAGLDEVKVGESYDLDGETIETIPSTTERWAQCEPNFQTFDGWPEVDWAAVAEEGYEALPENARTYLEYVAEEVDTDLYAVGLGPERDHTVVLDHPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3D4</accession>
    <name>R4W3D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00462">
        <property type="protein sequence ID" value="AGN00462"/>
        <property type="gene ID" value="L593_02555"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02555"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="34134" checksum="F21C260457846CE8" modified="2013-07-24" version="1">MAEFTPYSGSPLDIAVVYGIVSGAWILVSDRLVAALIDDPELTTTIQTAKGWLFVLGSALLLFGLIRHGQRSTERTNERLDRALQQTTILHRVLRHNLRNSCNVIAGNTELLAARADGGEVEDVQSREYIEPIREQTDELVTLTEKTRLLRDIVLEDELTERVDLDALLEERIDEERNRYPSATFELQSSAAVTVETDPRLHRAVDELLENAVVHCDHDEPTIQVAVEELPDGTARFDVADDGPGLPEVERALLEEGMESPMFHSEGLGLWITRSIVDNVDGDVTIVDNEPRGTIVRITLPQSGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3J1</accession>
    <name>R4W3J1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03055"/>
    <dbReference type="EnsemblBacteria" id="AGN00562">
        <property type="protein sequence ID" value="AGN00562"/>
        <property type="gene ID" value="L593_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.618"/>
    <dbReference type="eggNOG" id="arCOG02113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318492_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="23563" checksum="059EC57E5F5A0570" modified="2013-07-24" version="1">MTDEPRAADDRDAVEEQAADGGVAESAEADPLEAAIEENPEAVAEFVRRLDAVNELLDVVALGESAMTDEMVTELAGTGATLAESADGLATDETVALAETVGDNGEELQAALETMLELQRTGTLDDLAELASVGSLATAALDDEMVRSLAAMGGSLGEVADTAAAPETRDGIETMLEGIGEAQRAEPEPVGAIGMARAIRDPEVKYGLGYVLAMARAIGRARAEDASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3V2</accession>
    <name>R4W3V2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445631.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00737">
        <property type="protein sequence ID" value="AGN00737"/>
        <property type="gene ID" value="L593_03930"/>
    </dbReference>
    <dbReference type="GeneID" id="16180724"/>
    <dbReference type="KEGG" id="sali:L593_03930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.799"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418669_0_0_2"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="20275" checksum="065B8D937FC25B6D" modified="2013-07-24" version="1">MEHSGPPKGLVSYLVLELLEEKPRYGYEILKEIEAISGGHWEPSYGSVYPVLYKFEEEGWAERIEREDEPDRKYFQLTADGEDELADRREESAGKAHDFADTILGFYHVYVALARDERLDVPCKPDAWCFDEEFSAWMIEQMIRHHERDFGEFERIDATPEEFYAAHGVEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W410</accession>
    <name>R4W410_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445736.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04455"/>
    <dbReference type="EnsemblBacteria" id="AGN00842">
        <property type="protein sequence ID" value="AGN00842"/>
        <property type="gene ID" value="L593_04455"/>
    </dbReference>
    <dbReference type="GeneID" id="16180944"/>
    <dbReference type="KEGG" id="sali:L593_04455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.908"/>
    <dbReference type="eggNOG" id="arCOG01759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_2_1_2"/>
    <dbReference type="OrthoDB" id="81987at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16185" checksum="F9E610420AEC1B5D" modified="2013-07-24" version="1">MDAEIDAVRVAGTPQGPVPVVVLSVADEDDVVPIFVGFEEARSIARGMDATDIGRPLTHDLLLDVMEELGGKVNRVVVSEVTEEGTYIADLHVDTPRDGVVIDARPSDSMALASRTNVPIEVAESVFEEGRQPAEEFEELEDIRELSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W427</accession>
    <name>R4W427_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445766.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00872">
        <property type="protein sequence ID" value="AGN00872"/>
        <property type="gene ID" value="L593_04615"/>
    </dbReference>
    <dbReference type="GeneID" id="16181006"/>
    <dbReference type="KEGG" id="sali:L593_04615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.942"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076274_2_0_2"/>
    <dbReference type="OrthoDB" id="81550at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="24540" checksum="712B39EF872FA780" modified="2013-07-24" version="1">MSVIAEVRIPSDDFELGQILSLEQASAIELETLVPSGNVTVPLFWVYEPVENGFRETVERYPTVNSITEVDVFDDRTLIRLDWDASQDHLFQCILEHDGQILGATGSPDGWNFELRFANREALSQCQDCCEAAHITLELTRIYNPTDPEAGPWYGLSEPQREALTLAVRKGYYDIPRGCTTAELADELGISDQAVTERLRRSIGTFGRYALIPPASGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W434</accession>
    <name>R4W434_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">L593_04690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445781.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04690"/>
    <dbReference type="EnsemblBacteria" id="AGN00887">
        <property type="protein sequence ID" value="AGN00887"/>
        <property type="gene ID" value="L593_04690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181061"/>
    <dbReference type="KEGG" id="sali:L593_04690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.958"/>
    <dbReference type="eggNOG" id="arCOG04459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_2_0_2"/>
    <dbReference type="OrthoDB" id="18897at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="42142" checksum="909768DEB230BA03" modified="2013-07-24" version="1">MPRMETADIETDLSLFKYDNLEQLPAAYRELEAEERTARIESALEELGDDVVVLGHNYQRKEIVEHADFIGDSYQLSKEAANSDAEYVIFGGVTFMAETADVITDDDQTVILPSMEASCPMAGMAEALQVDAAWAEITAAAPDKDIVPVTYMNSYADLKAFTAEHGGAICTSSNASDVFEWALDKGDAVLFMPDKYLGINTAYDLGLEDSAVAWDPWDPEGTDAEEAADAEIILWEGYCQVHERFRASHIEEIREEHEDVNVVVHPECRREVVEAADVVGSTSTITETVANAEPGEKWAIGTEIHLANHLDRWYPEVEVLPLCGDACMDCNAMRQIDPNYLAWVLEELVEGRERNVIEVPEREAELAELSVQRMLDLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W454</accession>
    <name>R4W454_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ORF">L593_04865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445816.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04865"/>
    <dbReference type="EnsemblBacteria" id="AGN00922">
        <property type="protein sequence ID" value="AGN00922"/>
        <property type="gene ID" value="L593_04865"/>
    </dbReference>
    <dbReference type="GeneID" id="16181126"/>
    <dbReference type="KEGG" id="sali:L593_04865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.994"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_1_2"/>
    <dbReference type="OrthoDB" id="7487at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="282"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="455"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="603" mass="64167" checksum="27BF83B61FE739D5" modified="2013-07-24" version="1">MCGIVGYVGTGAALPVLATGLSNLEYRGYDSAGVALADGDLDVYKRSGEVDALRAALPESAPQHRGIGHTRWSTHGPPTDANAHPHTGCSGDVAVVHNGIIENYDALRAELDADGHTFTSETDTEVVPHLIEAELETGASPREAVRSAVERLEGSFAIVVTIAGDDELYATRRDSPLVVGHGDGEQFLASDVTAFLEQTREVTYLEDGDLAILAAGGVTIERDGETADPDRETLDWEADAAEKGGYEHYMLKEIHEQPAALRQTLSGRIDPDAGTVDLDLDLPAEYVSSLEEVQFVAAGTSNYAARYAAELVEELADVRATVEIASEYEFSGGRDPWRTLTVAVTQSGETADTLSAIRSASRAGARTLSVTNTLGSTVTRETDDSLFIRAGPEIGVAATKTFASQVATMTMLSVALGRQRGTLSSDRASEVLSSLRGVPGAVQQVLDRADDVGEVAREHADADAFFFVGRQYGCPVALEGALKLKEISYDHAEGFAAGELKHGPLALVTPDTPVLAIMTDGSRPDATLNNVKEVQARGAPVIGASSHEGADRYLDVEWPVPDVGVLEPLVANVYWQLFAYYVAESKDRSIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4F2</accession>
    <name>R4W4F2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445986.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05715"/>
    <dbReference type="EnsemblBacteria" id="AGN01092">
        <property type="protein sequence ID" value="AGN01092"/>
        <property type="gene ID" value="L593_05715"/>
    </dbReference>
    <dbReference type="GeneID" id="16181472"/>
    <dbReference type="KEGG" id="sali:L593_05715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1170"/>
    <dbReference type="eggNOG" id="arCOG02190">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_2"/>
    <dbReference type="OrthoDB" id="60543at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="41731" checksum="AF7DF07A0FA3EE78" modified="2013-07-24" version="1">MSTTEAHEHGPNCDCESCGDPRSMDFLDKYLTLWIFGAMALGVGLGHVAPSVTEPIQNLHLVEIGLIAMMYPPLAKADYSQLRAVFSNWRVLGLSLVQNWLIGPTLMFGLAVFFFSGLVPGLPARPEYFLGLVFIGMARCIAMVLVWNELAEGSTEYVTGLVAFNSLFQILTYGVYVWFFALVLPDQLGMTALADGITTFDVTPGQVFEAIVIFLGIPFAGGFLTRYVGTRTKGETWYDEAFVPRIDPLTLVALLFTVVVMFATQGDAIVASPGDVLLIAVPLTIYFVVMFLVSFRMGRSIGADYSTTTAIGFTAASNNFELAIAVAVAVFGVGSGVAFATVVGPLIEVPVLLALVHVALYFQRRYDWGGFDAGRLDGATAESAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4G9</accession>
    <name>R4W4G9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASPIC/UnbV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446016.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05865"/>
    <dbReference type="EnsemblBacteria" id="AGN01122">
        <property type="protein sequence ID" value="AGN01122"/>
        <property type="gene ID" value="L593_05865"/>
    </dbReference>
    <dbReference type="GeneID" id="16179832"/>
    <dbReference type="KEGG" id="sali:L593_05865"/>
    <dbReference type="eggNOG" id="arCOG08924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432058_0_0_2"/>
    <dbReference type="OrthoDB" id="9176at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="477"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="559" mass="60398" checksum="4C01931284F0E366" modified="2013-07-24" version="1">MRVGTGVAVLFLVVLTAGCIVSVAPATDSPPPSETELAFTEVSEEVGLSYASVEGGAGNGNDGIYVGNLDGDLRQDVFVIGGEQPALYRNTEDGLERSDALPNVTRLTEDGAGRIQSALWLEDDGDGYDELLLFPRNGTAVYLDNEEGQLVHENAGFETRYTNPVGASTADYDGDGCLDVFVAQYGLWYDGSPAGWHGEDWQEDNGNPNVLYRGSCGDGFERATDAGIGPDGRGPHWTLATSFVDLTGDGHPDIHAANDYFNDTLYVNDGDGTFTKRTMAGVTDRNGMSSEIADLQGDGRPEIFVTNIFFPEERIVELPAMERRLFSNFLNNRLGKRLQGNNILVANGSSYDGVGREVGIAEGGWGWGTVVADLDSDGEQDAFHSTQTVVTFDDDEPVYPLPGVWVQQDGQFYRQDADEIGLEVANGRGVGQIDYDVDGDVDVGVATYDESYRLYRNDGEQGASLQVLVGAGEERTAVGATVYATVDGDTQHYFANGRTDFQSQDSPVIHVGTGSDSVVEELRIVWPDGTERTFEDVETGQRIRVTPAGIQERLAYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P1</accession>
    <name>R4W4P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06450"/>
    <dbReference type="EnsemblBacteria" id="AGN01237">
        <property type="protein sequence ID" value="AGN01237"/>
        <property type="gene ID" value="L593_06450"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1314"/>
    <dbReference type="eggNOG" id="arCOG08631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="33392" checksum="CA338F306C64AAA8" modified="2013-07-24" version="1">MGVTMGDPAGIGAEIVVEGHDEIAALADVVVIGDASVLRAAVECCDSSLSVEAVDDVAEASFADDAVSVLDLDLVDDLEYGVIREEYGAASLAYVEKAIELAKAGTIDAITTAPIHKQATRMAGSEHAGHTGLLAARTDTDVYSMMLVHDDLRVSHVSTHVPLREACDLVTTEAVLDTIRVTDEGLRQLGVEEPIIAVAGLNPHASDGGLLGDEEAAEIEPAVERAREEGIDAVGPEPPDTVYPQAAGGAADCVVSMYHDQGHIPIKMLGFGDGAVTGVNVTIGLPIVRTSVDHGTAFDIAGTCQADPTSLIDAVEVAVRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W511</accession>
    <name>R4W511_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTP-binding protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446346.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07535"/>
    <dbReference type="EnsemblBacteria" id="AGN01452">
        <property type="protein sequence ID" value="AGN01452"/>
        <property type="gene ID" value="L593_07535"/>
    </dbReference>
    <dbReference type="GeneID" id="16181692"/>
    <dbReference type="KEGG" id="sali:L593_07535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1543"/>
    <dbReference type="eggNOG" id="arCOG00354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399745_0_0_2"/>
    <dbReference type="OrthoDB" id="61585at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="213" mass="23923" checksum="67A56203DC7C4885" modified="2013-07-24" version="1">MGLLTGLKASITRATDRLFSEEDPKRIGIYGPPNAGKTTLANRIARDWTGDAIGPESHVPHETRRARRKENVEIERNGKSVTIDIVDTPGVTTKVDYEEFLEFDIEEEDAVRRSREATEGVAEAMHWLREDVDGVIYVLDSTEDPFTQVNTMLVGIIESRDLPVLIFGNKIDLEESNIQRVSSAFPQHETVPLSALEGENMDEVYDKIAEYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W542</accession>
    <name>R4W542_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">radA</name>
        <name evidence="10" type="ORF">L593_07810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446401.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07810"/>
    <dbReference type="EnsemblBacteria" id="AGN01507">
        <property type="protein sequence ID" value="AGN01507"/>
        <property type="gene ID" value="L593_07810"/>
    </dbReference>
    <dbReference type="GeneID" id="16182231"/>
    <dbReference type="KEGG" id="sali:L593_07810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1600"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OrthoDB" id="30130at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="79"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="37136" checksum="89AD90D160FCB7B4" modified="2013-07-24" version="1">MAADADLEDLPGVGPATAEKLTDNGFDSYQGLAVASPGELSNTADVGESTAADIINAARDAADVGGFETGATVLERREQIGKLSWQVDEVDDLLDGGVETQSITEVYGEFGSGKSQVTHQLAVNVQLPQEHGGLHGSAIFVDSEDTFRPERIDDMVRGLPEEALEAMLEERDIEGDVGDDETLDALVDSFLEYIHVAKAFNSSHQMLLADKAQELASENEDAEYPVRLLCVDSLTAHFRAEYVGRGELADRQQKLNKHLHALEKVGNLYNTAVVVTNQVASNPDSFFGDPTQPIGGNILGHKSTFRMYLRKSKGDKRIVRLVDAPNLADGEAVMRIEGGGLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W570</accession>
    <name>R4W570_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446446.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08035"/>
    <dbReference type="EnsemblBacteria" id="AGN01552">
        <property type="protein sequence ID" value="AGN01552"/>
        <property type="gene ID" value="L593_08035"/>
    </dbReference>
    <dbReference type="GeneID" id="16181756"/>
    <dbReference type="KEGG" id="sali:L593_08035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1646"/>
    <dbReference type="eggNOG" id="arCOG02510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278447_0_0_2"/>
    <dbReference type="OrthoDB" id="43655at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="438"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="607"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1135" mass="116165" checksum="84861250CA3F51B0" modified="2013-07-24" version="1">MTSDLRRPGSDGSEGRRSRRDRNLASTIGALVAISVVALCLAAVPVAVTADSHANGSDPYVIEQGDQCVDVDPITNTSQTVVDFYDYRSPDTTPNATTYSSYGTTAYQADNTSVLMLYRGSEGTSLVIVHEKLHEPDTEGTNGSSATFNVTGISNDGDGWAVEDDNYDAQDDQFDHYPTYSEIDWVWSRGRTDGGAYRGLDGDVEIGIDPAFNESADLRYDDEYAGYVHDWQVITATEDGFERVSLDSLTQEVTVQDGYCAPPPNASLAVSNATPEAGLTSVPLDASDSNSSTGITEYRWDLTGNGSADEVTSDATLEHTFASAGERDVAVTVVAGDGQTDTAAVAVNVTDSTAPTAEIDAPLAAVVDEQLAISGNDSSDNDRIASYAWTFGDGTSATGATVEHSYASTGVYNLTLTVTDPSDHEATANQTVTVSQAPPNASLSAPGQATLNETVLLDASGTDAGPNATYEWVIDGTTANVTNASTYETAFAARGTHDVSVAVTDDGGFDSASATIDVYRPLNASLDATPLNVTAGEPVAFDANASTGNVTRYEWAFGDGATIADGNATVEHEYAAAGEYTAEVTAVGATGATDSTTVTVDVTPAPGPTAQLSAPGEVAVNETATLDASGSEAGPNATYEWSVDGEVLHTTSEPTYQTSFTTAGDHEVVVTVTDAGSTDDANATVSVVNESDGGDDSSGGGGDDSDDGGGGGGGGYGPPPVDPPEPEEPLETSVAVENGTIVVIAEHVDAGEAFVVDVPTNLTTGTNATGGATGSPNATGGANDSSDAAGGVNGSSPNASATAGDLDAVTLRSVEITPTSDAETLRVSFTRADRAVPGRFVRTPAFLSNASVSLASIRYEVGVDRTTMSAAGVSADDLTVYADDDGWTSVETNTSVAGPDIVVSTTVDGTTPLGVGAVGPVLYVSDVRTAGVVADGSFPIATTVRNTGSDRGDVSLPILVNGEPLATVTVTLTPGEQTVVESRVPIDGTRNVTVGAVGLRRTLPVVTITDFSARPAEPGLNETVTVEATLVNRGSGAGAFEAVLRRDGVVAATQTVSLAPGQRTTVTFRQMTSTAGTYRFTLGNVTETVNASRRSRFTGGGNGETQSAVPGFGALTAMTALAALLLVGILRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5P1</accession>
    <name>R4W5P1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="6" type="ORF">L593_09560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446751.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09560"/>
    <dbReference type="EnsemblBacteria" id="AGN01857">
        <property type="protein sequence ID" value="AGN01857"/>
        <property type="gene ID" value="L593_09560"/>
    </dbReference>
    <dbReference type="GeneID" id="16182741"/>
    <dbReference type="KEGG" id="sali:L593_09560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1968"/>
    <dbReference type="eggNOG" id="arCOG00574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_2_0_2"/>
    <dbReference type="OrthoDB" id="61905at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
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        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="311" mass="33050" checksum="97E72689E42222A0" modified="2013-07-24" version="1">MSESDAEFDKFSDVGEAEVTRAIGQEWTEEFMDFSDSDVIIVGGGPSGLMAAKELSERGVQVMVVEKNNYLGGGFWLGGFLMNKVTVRDPAQHVLEDLDVDFKQSQDSEGLYVANGPEACSGLIKAACDAGAKMQNMTEFTDIVIREDHRVGGIVMNWTPVHALPREITCVDPIAVEADLVIDATGHDAMAVKKLDERGVLNAPGIEDAKSNAGMDQTSDDTYGAPGHDSPGHDSMWVGKSEDAVVEHTGLAHDGLIVTGMATATTYGLPRMGPTFGAMLISGKRAAQKALDELGVDAEPVDMTSRQAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5P3</accession>
    <name>R4W5P3_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Aconitate hydratase</fullName>
            <ecNumber evidence="7">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_09585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446756.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09585"/>
    <dbReference type="EnsemblBacteria" id="AGN01862">
        <property type="protein sequence ID" value="AGN01862"/>
        <property type="gene ID" value="L593_09585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181964"/>
    <dbReference type="KEGG" id="sali:L593_09585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1973"/>
    <dbReference type="eggNOG" id="arCOG01697">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_3_2"/>
    <dbReference type="OrthoDB" id="2260at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="6">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="657" mass="70840" checksum="91F986DA0E9DF23C" modified="2013-07-24" version="1">MGQTLTEKILDDHLVEGELTPGEEIGIEIDQVLTQDTTGTMVWLQFEAMGLDEVQTEIAAQYCDHQTYQFDFKNTDDHRFLRSAAGTYGAYFSRPGNGICHNVHRENFAAPGKTMLGSDSHTPTPGGLGELAIGAGGIDVTVAMGGAPYYIEMPEVHSVRLEGELPEWATAKDVILELLRRLSVKGGVGKVLEYTGPGVETLSAPERMTITNMGTELGATSSIFPTDERTREYLEKVDREEEFVELQPDDDAEYADEIVVDLSDLEPLIAEPSMPDNVVPVREVAGQDVDQVMVGSCTNGAFADILPAAKMLEGREVNMTTEMIVAPGSKQASEMLARQGWVAEMMAAGVNFSEATCGACIGIGHVPASDSVSLRTFNRNFEGRSGIEDDNVYLCSPEVATAAAIKGEIVDPRDLADELGDLEDPGFELPEEYTGSKTDLITPDEAPDDELVKGPNIGDVPIKDALEADIDGPAILKMGDNITTDHIIPATQDILMYRSNIDKLSEFTLSRVDDTFADRAAAADGGWLVAGENYGQGSSREHAAMCPMYLGIEGVLAQSFARIHRANLFNFGLVPLLIDEDTYEQIEQGDDIAVVDDVHEGVASGKEEFTIRVNDDWEATATLDASERERAMLAAGGKLAWTKQQAEGGSGAAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T0</accession>
    <name>R4W5T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase/oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444872.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00115"/>
    <dbReference type="EnsemblBacteria" id="AGM99977">
        <property type="protein sequence ID" value="AGM99977"/>
        <property type="gene ID" value="L593_00115"/>
    </dbReference>
    <dbReference type="GeneID" id="16181220"/>
    <dbReference type="KEGG" id="sali:L593_00115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.23"/>
    <dbReference type="eggNOG" id="arCOG03015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_5_2"/>
    <dbReference type="OrthoDB" id="84415at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="31892" checksum="28E6A4197A66B57A" modified="2013-07-24" version="1">MEVLVTGGTGFIGSALAAELRDRDHDVTVLARDPDGDGVPDGVMSAAGDVTDYDSIEPAFEGMDAVVNLVALSPLFKTPSGLSHESVHLGGTKHVLDAATEHDLDRIVQMSALGADSDGPTEYLRTKGEAESAVRDATIDHVIVRPSIVFGDGAELVPFTKRAKQMFAPGLPIAPLPGGGKTRFQPIYIGDLVPMLADCVEGDDHANSTYEFGGPEVLTLAELTRLVYRAEGKTMRVVPIPMPVAGLGLAVLGTVPPFPFNSEQYRSLRVDNTVSENDVTAFGRSPDELVTFEEYLGIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U6</accession>
    <name>R4W5U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446841.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01947">
        <property type="protein sequence ID" value="AGN01947"/>
        <property type="gene ID" value="L593_10010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180284"/>
    <dbReference type="KEGG" id="sali:L593_10010"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_3_2_2"/>
    <dbReference type="OrthoDB" id="122935at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="11914" checksum="A6203E15DA684D63" modified="2013-07-24" version="1">MIQSPTDSTDTVTSAADLPPDDRHRLLAAERRRVALEVLTDWTEPVDLESLAAAVATREGDDVGADGTNVEHVAITLHHAHLPMMADFGVIRYDSEATRVEACPREHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X1</accession>
    <name>R4W5X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01987">
        <property type="protein sequence ID" value="AGN01987"/>
        <property type="gene ID" value="L593_10210"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2104"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_9_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="39"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="163" mass="17999" checksum="155C0E9B3817757E" modified="2013-07-24" version="1">MLAAVVTPANSEAHRTFFPTCSDANCMGHDWADADHAGQLHHVELYASDLDASADFWGWLLGELGHEPKDDWDGGRSWVNGPTYVVLIEAEDEEPAYDRNAPGLNHLAFHAGSREQVDRIIEGVRERSDASVLYPDQHPHAGGYYALYCEDPEGIKVEVVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X4</accession>
    <name>R4W5X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10235"/>
    <dbReference type="EnsemblBacteria" id="AGN01992">
        <property type="protein sequence ID" value="AGN01992"/>
        <property type="gene ID" value="L593_10235"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2109"/>
    <dbReference type="eggNOG" id="arCOG02296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_24_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="19107" checksum="565ADA23E9B166DF" modified="2013-07-24" version="1">MYDLDGTLVRLDVDWQEAASDVVAVYEDAGHDVDPDRDLWSLVNEAGRYAVQDEVEAVLSEHERAGAEASEALPLADEVDSTRDPIGVCSLNCEDAVEIALEKHGLDRYVNSLVGRDTLREQKPDPTPLLTALDQIGATPVSTVFIGDSATDEQAAERAGIPFQWVEDRVQQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X7</accession>
    <name>R4W5X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446891.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01997">
        <property type="protein sequence ID" value="AGN01997"/>
        <property type="gene ID" value="L593_10260"/>
    </dbReference>
    <dbReference type="GeneID" id="16182147"/>
    <dbReference type="KEGG" id="sali:L593_10260"/>
    <dbReference type="eggNOG" id="arCOG04521">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046089_0_0_2"/>
    <dbReference type="OrthoDB" id="39971at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="478" mass="48874" checksum="CBCB9B494B55568F" modified="2013-07-24" version="1">MSVNRALFAAMLREEWRLHVRLFGGWRFAAFPIVVAALTASAVAALAWAGVDVAVAIAGLHALVFAFGLQTGSMGLVAQDALERMLGEISLLVSTWHHLPLSRSRVVAAFLIRDLVYYSGLIFLPLAVAFVPAGLLYDDALLAAAPRLLVSLPATFALGLATTTALIALVQRGIPGTLLVLGLLAGVGGAIWTGLPIADVSPYGLYDDPSLLAVAGTAVGIAITASVGFTGLGRSDPRPARTREPALGALADRIGDDRGLVARSLLELSRSAGGLGTIAFSATVLLAVAGGVVALVSRIGGVDPQAGLTFGPLLGLSAFTSYNWLTTAADAPSYRRFPLSIGDVVAAKRRALALVGLPVGVVALAVALVWLGTTPVDAGLGLLLFAGIHVYVGGLTAFLAGLQPNEFLFDTVLFAAFGLAVLVPLAPLLIVALVVPSPGPGLLAGVATTALVLGVVGTVLGRRAGPRWEAQYRSGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y6</accession>
    <name>R4W5Y6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446906.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10335"/>
    <dbReference type="EnsemblBacteria" id="AGN02012">
        <property type="protein sequence ID" value="AGN02012"/>
        <property type="gene ID" value="L593_10335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181605"/>
    <dbReference type="KEGG" id="sali:L593_10335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2130"/>
    <dbReference type="eggNOG" id="arCOG00329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_2_2"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="3">
        <location>
            <begin position="341"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="779" mass="85420" checksum="5391DAC06216063F" modified="2013-07-24" version="1">MAFTIDVRDDGTPVRWELDPDGGATPTADPDYQPAIYVAARDDRTGALEWLADALADDPKVAAVERVERYRSLRADERSPMCELRLDRLDEVRQVARELRRREHEQFLPGTFQLYDVDLDPGFRYVLDRGLDPTPDRDLVTLDLALPEPAVANGDVRPLEIDGEPATPDGTGAGSAAAEAAVADAVESVLDARDPDVLLLSSGEIVPLLADADVDLGRRPGFSRIAGESTFVSYGQVGYSPARYDVPGRALVNRSNSFLLGHSALAGLLYFVERAGKPLQEIAKDSIGGVLTAIEIRAARQWDGERVVDRVPGRRDGVPAPWQKRQTEGWKPLDTLHAADRGGFTFQPDPGLHEHVHELDFASLYPNVICEYRVSPDTVCCDCHDASDVSAVDASAEPLDPDLRVPELDYSVCPDGDAFLAEVLEPLIEERQERKAVVRDAGPTEDTAADEAVVEAIKWVLVSCFGYQGYRHAKFGRIEVHEAINAHAREIMLTAKAMLEDAGWRIVHGIVDSVWVTAAPDREQRPIREVATEITEAVRIELEYEGEFDWVAFCPRKRASGAALMRYFGRWADAELDAAGDDESPSDDPFKLRGIEARQRSTCQFVADAQRDLLETFDRERAPEPVCDRLERHLRRLRSGTVDSADLAITQRVSKAAGDYEQATRAKAALQRAAAVGVPRSPGQDVEYVVVDDALSGPERVRLAFELDEHAGAGSATTGAPATTGGAATDDPASYDAEFYADRLLRACESLVAPLGWNEGRIRSHLQHDRDATLSAFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W628</accession>
    <name>R4W628_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_10660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446971.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10660"/>
    <dbReference type="EnsemblBacteria" id="AGN02077">
        <property type="protein sequence ID" value="AGN02077"/>
        <property type="gene ID" value="L593_10660"/>
    </dbReference>
    <dbReference type="GeneID" id="16182470"/>
    <dbReference type="KEGG" id="sali:L593_10660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2198"/>
    <dbReference type="eggNOG" id="arCOG02546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="96"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="336"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="426"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="816" mass="85012" checksum="D8C4C000D6A032BF" modified="2013-07-24" version="1">MNESRRSILRKASALSALAVGASATASAADCSSVSDWQNDVSYSSGDQVQHPDTDGIECLWEAALNSLNAEPSRSSAYWDYVGDCDGSGGGSNSAPTASFTTSISNPAPGEDVSFDGSGSSDSDGSISSYSWDFGDGSSGSGQSVTHSYSSTGDYTVTLTVTDDDGATDSASQTVSVTSSSNSAPSASFTVSPSSPTTGESTTFDAADSSDSDGSISSYSWEFGDGSSGSGQSVTHSYSSTGDYTVTLTVTDDDGATDSNATTVTVQSDSGGGGVDCSGVSEWQSDVAYSGGDQVTYEGDLFTAEWWTKNDPPDDSKNVWTLEGSCSSSGGGNSDPVASFTSSPSSPDPGEQVAFDASGSSDPDGDSLSYSWDFGDGSSGSGQTTGHTYSSEGDYTVTLTVSDGNGGSSTDSTTLSVASGGSTGGNRIVGYWMQWAQYDRDYVPADIPKDQVTHLQYAFMRPESDGTISGLGDSSAQKYLFPQSWHDVTSFGDIASNTDVTCLISIGGWSDSENFSDVALEESSRQKFADECVRIVREAGVDGVDIDWEYPGGGGHPDNTVRDGDQERFTLLVQAVRDALDAAGAEDGKDYKLTAAMVSGGSKAEGLEHGTLSGLFDFVSIMTFDMRGGFSDYTGHASPIFQNPNDPSSKASTYNVSSGVSWYVDKGWDPGQLNIATPFYGRSFSSVEAPSGDLGNGTDDGLFQNFSGTGGGSFPPDTESSGIYDYWDLSTVGTARSTSQVDLSSSDWTTSYDDTAKATWSYNQTDSLMISHPTPDSVQQRASWLANSDYGGTMIWALSHDTVEHHLLGELSNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W633</accession>
    <name>R4W633_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445032.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00915"/>
    <dbReference type="EnsemblBacteria" id="AGN00138">
        <property type="protein sequence ID" value="AGN00138"/>
        <property type="gene ID" value="L593_00915"/>
    </dbReference>
    <dbReference type="GeneID" id="16182222"/>
    <dbReference type="KEGG" id="sali:L593_00915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.188"/>
    <dbReference type="eggNOG" id="arCOG01345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152992_0_0_2"/>
    <dbReference type="OrthoDB" id="109038at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="101" mass="11670" checksum="A4C33F5B7778B255" modified="2013-07-24" version="1">MIDRLEKEVDMLERHLQVLRMVIENEPIGIVKMSNETGYPHHKVRYSLRVLEEENLIEPSSQGAITTERTAEFIDELDDKIDETVDTLEGMKLEDAAELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W691</accession>
    <name>R4W691_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl30p</name>
        <name evidence="2" type="synonym">rpl30</name>
        <name evidence="4" type="ORF">L593_11210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447081.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11210"/>
    <dbReference type="EnsemblBacteria" id="AGN02187">
        <property type="protein sequence ID" value="AGN02187"/>
        <property type="gene ID" value="L593_11210"/>
    </dbReference>
    <dbReference type="GeneID" id="16182044"/>
    <dbReference type="KEGG" id="sali:L593_11210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2312"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OrthoDB" id="79065at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="16872" checksum="06B99BC4DFE91FEB" modified="2013-07-24" version="1">MYAVVQLRGEVNVSEDVVDTLEMLNLHHVNHATLVPATETYEGMITKVHDVVAHGEPSEEVVATLLRTRGEPLEGDADTDDEWIDEHTDYDDADDLAAALVAEETTLREEGMSPVLRLHPPRGGHEGIKQPTSTGGQLGVHSTEQIDELLTAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E8</accession>
    <name>R4W6E8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ORF">L593_01935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445232.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01935"/>
    <dbReference type="EnsemblBacteria" id="AGN00338">
        <property type="protein sequence ID" value="AGN00338"/>
        <property type="gene ID" value="L593_01935"/>
    </dbReference>
    <dbReference type="GeneID" id="16179937"/>
    <dbReference type="KEGG" id="sali:L593_01935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.394"/>
    <dbReference type="eggNOG" id="arCOG04229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OrthoDB" id="101957at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16615" checksum="10E542FEF3FDEFC5" modified="2013-07-24" version="1">MSERELRISKIENGTVIDHVPGGEALNVLAVLGIDGTGGETVSIGMNVESDALGRKDVVKVEDRELSQDEVDVLSLIAPEATINIIREFDVVEKKRLDRPESVSGVLACPNHDCITSGDEPVETKFEVLDSGVRCVYCETIIREDITDHIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G9</accession>
    <name>R4W6G9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11820"/>
    <dbReference type="EnsemblBacteria" id="AGN02307">
        <property type="protein sequence ID" value="AGN02307"/>
        <property type="gene ID" value="L593_11820"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2433"/>
    <dbReference type="eggNOG" id="arCOG01378">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039939_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="454" mass="48093" checksum="26E394E206C2E26C" modified="2013-07-24" version="1">MTSEMYETDASAALLERCRRDEIVHPDYGGYCIEGVPGTAAGVLGVDVGQPDPSGVSDVSASLPAETLGGAVGASSPAEAHSDVSHPDLSQVVVLVIDGLGWHRFHRDASDRRFVGRFLERGSVTPLTSVLPSSTGAAIPTLHTGAPPAEHGVLGWDVRLPEHDAIVEAFPHAVRDGVEETTPPIPPSGVVRSEPIYPALEAADVETRVVQPAGTLGTAYANATFRGATQVPYDGIEDGAEVLRSVLESSAGPSYTYVYVPDVDAVSHTSGSDSAAYHEVLETVCSALARALYDDLDAATARETLLLVTADHGFVDFDPGPEGCLDPTTIQAVADALERRPNGDPVPPWGDYRVSHLAVRDGERATVRRTLEARGAIVFDDETVTDVELFGPAPSSAFQRRCGDLVCTHPERKIVHPAAERIVPKIGMHGGPTARELLVPFAAARVSRLRCENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I7</accession>
    <name>R4W6I7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">L593_12045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447246.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12045"/>
    <dbReference type="EnsemblBacteria" id="AGN02352">
        <property type="protein sequence ID" value="AGN02352"/>
        <property type="gene ID" value="L593_12045"/>
    </dbReference>
    <dbReference type="GeneID" id="16180788"/>
    <dbReference type="KEGG" id="sali:L593_12045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2478"/>
    <dbReference type="eggNOG" id="arCOG03054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060478_0_0_2"/>
    <dbReference type="OrthoDB" id="63405at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_A">
        <property type="entry name" value="SecF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024921">
        <property type="entry name" value="SecF_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="31768" checksum="D744805BC00807AF" modified="2013-07-24" version="1">MRSFDVPEPDFDRYTNRQLAAVPLALLALALVVVGANVMLIGAPAPLGIEFTGGTELVIDTTGSADDVRTAFDTQPEDIQTVQGQSNRYIVTFGPDAGENGPSVQDQANDRLEPPSGNDAVVQGVSSVDATFAENTQRLALIGIIAAFVGMSVIAFALFRVFVPSVAIVISAFSDIMIPLALMGIVGYELSLGTVAALLMLIGYSVDSDILLNNHVLRRGTGGDFYDDVHRSMKTGVTMTVTSMAAMATMAIVAYLFGIDLLTAIGTILFVGLAADIMNTYMLNVTLLRWYKFEGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J3</accession>
    <name>R4W6J3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447256.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12095"/>
    <dbReference type="EnsemblBacteria" id="AGN02362">
        <property type="protein sequence ID" value="AGN02362"/>
        <property type="gene ID" value="L593_12095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182579"/>
    <dbReference type="KEGG" id="sali:L593_12095"/>
    <dbReference type="eggNOG" id="arCOG09081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130236_0_0_2"/>
    <dbReference type="OrthoDB" id="97065at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="20669" checksum="8F537075FE092388" modified="2013-07-24" version="1">MRRIYDSSALHRDDAETHAPRERNREARPQAMRSVPSGFLSKLFVPYWLRYRAVSVDVSTPDRTFEQGQRVPFTIRMRNELPIPITLPIESPLPWTWAVDGHPEASHVQRTTVPDERRGYHFDRGEAKEFTRHWSGSFRIARREWEPAAAGEHAISVAVNVANPADVGLEATTTIRIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q9</accession>
    <name>R4W6Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445417.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02860"/>
    <dbReference type="EnsemblBacteria" id="AGN00523">
        <property type="protein sequence ID" value="AGN00523"/>
        <property type="gene ID" value="L593_02860"/>
    </dbReference>
    <dbReference type="GeneID" id="16180357"/>
    <dbReference type="KEGG" id="sali:L593_02860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.578"/>
    <dbReference type="eggNOG" id="arCOG04779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_2"/>
    <dbReference type="OrthoDB" id="66502at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="29625" checksum="86BA4E77ED3FF574" modified="2013-07-24" version="1">MDLIVHGGAGSAPEEPEPRQRALDAAATAGTAENSPLDAVEVAVRALEHDPRFNAGVGSSVQADGIPRTDAGVMTSDRSIGAAASMPGVEHAVTVARVVMEETPHVQIAGVHAVDLAEQFGVPVEVDLWCDRTREHWDDLGGPPRHLGVQVDWVNEQYGEADSGGGEEGPTGTVGAVAREDEQIAAATSTGGRWAALAGRVGDVPQVGSGFFATEAAGASATGAGEDIVRTTVAKEAVGAVEDGMDADAAATAAIDAFGDHATGTAGVIVADADGRLGSAFDSEAMQTATARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6V8</accession>
    <name>R4W6V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445492.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00598">
        <property type="protein sequence ID" value="AGN00598"/>
        <property type="gene ID" value="L593_03235"/>
    </dbReference>
    <dbReference type="GeneID" id="16180346"/>
    <dbReference type="KEGG" id="sali:L593_03235"/>
    <dbReference type="HOGENOM" id="CLU_2127940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="113" mass="11458" checksum="3A2E9C405B576B9F" modified="2013-07-24" version="1">MIDPLLLVFGFGREDLIANAGIAGGIAMSLAVVAMLVVSVLPAYSESWAERLGTSNTTPAGPDPKEVIPGRDEPIEAPGQADVVAPDAAGDDTLENTGSSAIPEPQTAGADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z4</accession>
    <name>R4W6Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445547.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03510"/>
    <dbReference type="EnsemblBacteria" id="AGN00653">
        <property type="protein sequence ID" value="AGN00653"/>
        <property type="gene ID" value="L593_03510"/>
    </dbReference>
    <dbReference type="GeneID" id="16180577"/>
    <dbReference type="KEGG" id="sali:L593_03510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.712"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_2"/>
    <dbReference type="OrthoDB" id="89591at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="20842" checksum="60C410B4880242DF" modified="2013-07-24" version="1">MQSDGSPTVVAICGSLRDASKTRIALREVLDAASDAGAETELIDLREYDLPVFDADDRDAGDAPDLKRTVERADAVVFGTPNYHGSFSAPLKNALDYCGRDELAGSTVGLLEVAGGDYPKSAMMHLRTVARTLNAWTLPLEVGIPAAYDTVGDDGIEDPDIESRVRELGAQLVDYAGVDAYPEVAGTPAEAPLADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D8</accession>
    <name>R4W7D8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="5">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="6" type="ORF">L593_14580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447746.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14580"/>
    <dbReference type="EnsemblBacteria" id="AGN02852">
        <property type="protein sequence ID" value="AGN02852"/>
        <property type="gene ID" value="L593_14580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181331"/>
    <dbReference type="KEGG" id="sali:L593_14580"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OrthoDB" id="121943at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="PTHR17453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10290" checksum="A1C9D9769AC364AB" modified="2013-07-24" version="1">MVENVLWPAYFDADLSRSDGRRVPSDLAVEDPTVEEIAEAVGQVGYDATVERDVAYPREHYQKRGRIVVHDATDTGKADLIQAVGAYVTALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I0</accession>
    <name>R4W7I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02922">
        <property type="protein sequence ID" value="AGN02922"/>
        <property type="gene ID" value="L593_14940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14940"/>
    <dbReference type="HOGENOM" id="CLU_2821077_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="6655" checksum="03236262D786B846" modified="2013-07-24" version="1">MGRTLGLFAVLLGTSVVLVSHAGVVEGSFAHEAGWQRFIGAIGGTLVGIGIITWGGTKYAGVGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7L3</accession>
    <name>R4W7L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445922.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05395"/>
    <dbReference type="EnsemblBacteria" id="AGN01028">
        <property type="protein sequence ID" value="AGN01028"/>
        <property type="gene ID" value="L593_05395"/>
    </dbReference>
    <dbReference type="GeneID" id="16181352"/>
    <dbReference type="KEGG" id="sali:L593_05395"/>
    <dbReference type="eggNOG" id="arCOG08206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204978_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="69" mass="7395" checksum="35AEF0331A5E49BC" modified="2013-07-24" version="1">MNLDDLPVVSQVFESGADDRVFDSLLLLGPVVIVLIVLLGRSLLTAVLAVFYLGVFCGYVVYRGATFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S6</accession>
    <name>R4W7S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444918.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00345"/>
    <dbReference type="EnsemblBacteria" id="AGN00024">
        <property type="protein sequence ID" value="AGN00024"/>
        <property type="gene ID" value="L593_00345"/>
    </dbReference>
    <dbReference type="GeneID" id="16179869"/>
    <dbReference type="KEGG" id="sali:L593_00345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.69"/>
    <dbReference type="eggNOG" id="arCOG04766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080164_0_0_2"/>
    <dbReference type="OrthoDB" id="61157at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="28691" checksum="EC5F158FF5D5B9C7" modified="2013-07-24" version="1">MAHVERIDTYPVKGFDRCPLESARILDGGTLEHDREYALYDVDGDVINGKRTDRVHHVSATYDPETGTLTIQGPDLPSRRFVLPAEREAAASHFGTIFDAELRLQRNATRGFVDRPSMGPSVISTATLETVSSWYDSMTLDGARRRFRANMEVGGVPAFWEDRFVGEGAPAFRIGGVRFEGVTPCGRCVVPGRDPDTGEEIDGFRETFVERREASFPEWADRDALDHLFTLRLIARVPEVDRGSSITVGDDVEIIEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z9</accession>
    <name>R4W7Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446257.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07080"/>
    <dbReference type="EnsemblBacteria" id="AGN01363">
        <property type="protein sequence ID" value="AGN01363"/>
        <property type="gene ID" value="L593_07080"/>
    </dbReference>
    <dbReference type="GeneID" id="16182010"/>
    <dbReference type="KEGG" id="sali:L593_07080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1447"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035002_0_0_2"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="45939" checksum="7222401CEC5996E5" modified="2013-07-24" version="1">MTDTASIDGSQGLQQGIREHLGQFSLHVLLVFATGLTIGSERAVVPVLGRDVLGVQSLFVIGSFVVSFGIVKSILNLYAGKWGETYGRKPVLILGWATALPLPIVLIVAPSWAWITLGNVLLGINQALTWSMAINAKIDLAGPDQRGLAVGIDEAFGYTGVAAGAWITGLIAAQTSLRPEPFYFLGIVVVLAFLISIFLIKETVQYARAEGDEDHHDANLPFAAVLRRATYGDRTLFAAAQAGHVENFVDTLFWIAVPLYLTSEGLGIAAVGVVVGVHSAMYFLQIATGGLADRIGRRPPVVAGMFLAGGGVLAMVLVEGYLPWALFAAVSGLGMALLYPNLMTVPGDAAHPSWRSAGMGVYRMWRDSGYAVGAIAIGLAMQFASAEAAFYLTAILMFASGAVVYAWMEETHPEFGTHEPPAPADDGGVAATSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W804</accession>
    <name>R4W804_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446282.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07205"/>
    <dbReference type="EnsemblBacteria" id="AGN01388">
        <property type="protein sequence ID" value="AGN01388"/>
        <property type="gene ID" value="L593_07205"/>
    </dbReference>
    <dbReference type="GeneID" id="16182080"/>
    <dbReference type="KEGG" id="sali:L593_07205"/>
    <dbReference type="eggNOG" id="ENOG502N5HP">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144225_0_0_2"/>
    <dbReference type="OrthoDB" id="106085at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025356">
        <property type="entry name" value="DUF4260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14079">
        <property type="entry name" value="DUF4260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12575" checksum="50E37AA303BA04D2" modified="2013-07-24" version="1">MDTRLYLRFEAVGIAVATIAAYQQFGGGLLLFVLLLFAPDVAAVGYLLGDDIGAVTYNLAHVYVWPLGLVGVGLWSGSGLAVSGGLIWTFHVAMDRSIGYGLKAGSFRETHLGRIGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W809</accession>
    <name>R4W809_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
            <shortName evidence="3">DHQ synthase</shortName>
            <ecNumber evidence="3">1.4.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate synthase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroB'</name>
        <name evidence="4" type="ORF">L593_01230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:25956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="EC" id="1.4.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal-type DHQ synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445093.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01230"/>
    <dbReference type="EnsemblBacteria" id="AGN00199">
        <property type="protein sequence ID" value="AGN00199"/>
        <property type="gene ID" value="L593_01230"/>
    </dbReference>
    <dbReference type="GeneID" id="16180458"/>
    <dbReference type="KEGG" id="sali:L593_01230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.250"/>
    <dbReference type="eggNOG" id="arCOG04353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056379_0_0_2"/>
    <dbReference type="OrthoDB" id="29853at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102042">
        <property type="term" value="F:dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01244">
        <property type="entry name" value="Arch_DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="43118" checksum="F443C9B30050E617" modified="2013-07-24" version="1">MTRSVWLKADDEVGDWEERKRRITAGLESGVDWVLVDEHDVGRVKELGDVKVAAFSTGGDAAMIDDAEGDGDAGPEADAYVVGKDGEGDGTVDLPNDLSGSADLSTLRRDDDRATGSYVRIFDSDYEGFAESAAQEAEYTIVIGENWQIIPLENLIARIGDETTLIAGVTEAEEARTAYETLEIGADAVLLDSSDPDEIRETVAVHDEADRETLELRWAEVTGIERAGSADRVCVDTGQLMDHDEGMLVGSMSRGLFFVHAETAESPYVASRPFRVNAGAVHAYVRTPDGGTKYLSELESGDEVQVVDTDGNTREAVVGRAKIEQRPMFRLEAEVETDDGVDRVETLLQNAETIKVPTSDGRTAITDVEEGDEVLIYYEDTARHFGEAVEESIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W810</accession>
    <name>R4W810_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446302.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07315"/>
    <dbReference type="EnsemblBacteria" id="AGN01408">
        <property type="protein sequence ID" value="AGN01408"/>
        <property type="gene ID" value="L593_07315"/>
    </dbReference>
    <dbReference type="GeneID" id="16182836"/>
    <dbReference type="KEGG" id="sali:L593_07315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1494"/>
    <dbReference type="eggNOG" id="arCOG06106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059557_0_0_2"/>
    <dbReference type="OrthoDB" id="66625at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="180"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="310" mass="32209" checksum="E474AA3A9B496842" modified="2013-07-24" version="1">MDSDALPAATGIGRVALRVADLADTTAFYVDVLGFERLDPAAVPDVVPAPEGDRAVLGAGGDALLVLEEAPDAPSRSPDEAGLYHVAIRVPNRPSLGAAIVRCRERDLLDGAADHGVSEAVYLRDPEGNGLELYADRPKAEWPLAPDGRVEMVTDPLDLDALVALAGDDPADAPLPAGTTIGHVHLEVTDLDATNDFYADALGTNLRQRMGEQALFLAAGDYHHHVGANTWRRRSAPASPDSPGLGWFEVVVPDDAALDAAADRLEASGVAVDRFGDGEATASGLVVASDPDGVVVRLRVDGAIAAPTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B6</accession>
    <name>R4W8B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446532.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08465"/>
    <dbReference type="EnsemblBacteria" id="AGN01638">
        <property type="protein sequence ID" value="AGN01638"/>
        <property type="gene ID" value="L593_08465"/>
    </dbReference>
    <dbReference type="GeneID" id="16182425"/>
    <dbReference type="KEGG" id="sali:L593_08465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1734"/>
    <dbReference type="eggNOG" id="arCOG05978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082825_0_0_2"/>
    <dbReference type="OrthoDB" id="92591at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015987">
        <property type="entry name" value="UCP022704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="PTHR35332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022704">
        <property type="entry name" value="UCP022704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="19623" checksum="E06D01AA359547C6" modified="2013-07-24" version="1">MDWYNEPAEWSETDDRLTVAVEGDTDFWRHTLHDFVADDAHFYHRDVSGDFTATVKLTGDYAAQYDQAGLMVREDETTWVKCGVELLDGVQQAGAVITRDASDWSVLPLAEDPDSVWIQVERIGSAVEVSYSLDGEAFMLLRQGYLSDAETLRVGPMAAAPQGEGFEVVFENFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G7</accession>
    <name>R4W8G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division inhibitor MinD-like (ATPase involved in chromosome partitioning)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446652.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09065"/>
    <dbReference type="EnsemblBacteria" id="AGN01758">
        <property type="protein sequence ID" value="AGN01758"/>
        <property type="gene ID" value="L593_09065"/>
    </dbReference>
    <dbReference type="GeneID" id="16182611"/>
    <dbReference type="KEGG" id="sali:L593_09065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1859"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OrthoDB" id="106200at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="22095" checksum="042B1E9FEEB1982F" modified="2013-07-24" version="1">MILAVVGGKGGVGKSTVALNVGAELDGVVVDADLGMADLPYGPGPDLHDVLAGRADPLEAVRERGGASVDVLPCGRTLAGARAADPTALVDALRRVESHYGAVVVDCPAGMAADAGLPLCAAGRCLLVTTPDGVAVPDALRTRALARVLDAGIERVVLNRARDPPVDRVQRTLGAPVTVVPEHEAVDRARNEGRAVASVAPESVPTERFSELAGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G8</accession>
    <name>R4W8G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445533.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03440"/>
    <dbReference type="EnsemblBacteria" id="AGN00639">
        <property type="protein sequence ID" value="AGN00639"/>
        <property type="gene ID" value="L593_03440"/>
    </dbReference>
    <dbReference type="GeneID" id="16180831"/>
    <dbReference type="KEGG" id="sali:L593_03440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.697"/>
    <dbReference type="eggNOG" id="arCOG02705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_2"/>
    <dbReference type="OrthoDB" id="21634at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="261"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="514" mass="56501" checksum="EAFBFAC21A1A9211" modified="2013-07-24" version="1">MEDRLDELEELQAEAELGGGEGRIESQHDKGKKTARERIEYFLDDGTFNEFDQLRTHNTHNFGMEERQLLTDGVVTGYGEVDGRTVFVFAHDFTVFGGSLGEVFAEKITKVMDKAMEVGAPLVGLNDSAGARIQEGVDALAGFAEIFRRNQEASGVIPQISSIMGPCAGGAVYSPSMTDFIFMVNDTSHMYITGPSVIETVTGEEVTHEELGGASTHSSKTGVAHFAASDEEQALDDIRRLLSYLPQNNVEDPPRVEPWDEPDRQDAELREIVPPSPQKPYDMTNVLDSVLDEGSFMEVGERFAAEIVTGFGRLDGRSVGVVANQPRVNAGTLTVDSSMKASRFVRFCDAFNVPILTFVDVPGYMPGTDQEHRGIIRHGAKLLYAYSEATVPLLTVITRKAYGGAYCVMSSKHLGADVNYAWPTAEIAVMGPQGAVNVLYSDELEAADDPDELREELIAEYREQFANPYTAADKGYLDDVIDPIETRPRLIDDLEMLQSKREANPDKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T5</accession>
    <name>R4W8T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02073">
        <property type="protein sequence ID" value="AGN02073"/>
        <property type="gene ID" value="L593_10640"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2194"/>
    <dbReference type="eggNOG" id="arCOG04551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131641_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="25850" checksum="ABC9B31B60B9E45F" modified="2013-07-24" version="1">MKAVRDRPAVMTVVALPAEPPRAGHALSDLVEADVCTPDEAAALYEAMVQDAVATVARSGGDLLVNYPPAADYHDAVDPEAELREVVGTVLDDPDSVRYEVQVGSTESARIGNTITHLLREEGVDTAAILRPEAPLAGRTAIDAAAMKLRSDPVVLGPAPSGRVYYAGFAEPIDFEDAFAAPAVETITDRAADADLGVNFEAMQPLLKEVGDVGDLLPMLRARIRADGLVPEATANVVSELGLGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W917</accession>
    <name>R4W917_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446018.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01124">
        <property type="protein sequence ID" value="AGN01124"/>
        <property type="gene ID" value="L593_05875"/>
    </dbReference>
    <dbReference type="GeneID" id="16181522"/>
    <dbReference type="KEGG" id="sali:L593_05875"/>
    <dbReference type="eggNOG" id="arCOG11257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191132_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="12144" checksum="59D5C83D4BD947D9" modified="2013-07-24" version="1">MSSDRSQATPGPSQPDEFWPRFWFNVCSYSEYYFMLLIAVTIMAVLNAVAMLLAEQSTASFVIATMVFVILGLTALAVGFVLWQCKQLRGPDREKLEGVEPTDRSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W931</accession>
    <name>R4W931_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447207.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11850"/>
    <dbReference type="EnsemblBacteria" id="AGN02313">
        <property type="protein sequence ID" value="AGN02313"/>
        <property type="gene ID" value="L593_11850"/>
    </dbReference>
    <dbReference type="GeneID" id="16181727"/>
    <dbReference type="KEGG" id="sali:L593_11850"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700230_0_0_2"/>
    <dbReference type="OrthoDB" id="122341at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="16737" checksum="15941EB798477419" modified="2013-07-24" version="1">MDELGGIYARSVPSLDATVQLGVASGKLIQCSFPATPEANAESEHELLDRIEAYAEQETEDDFRDVEIALTIPSDQRAVLQTLRTVPYGETTTVESLVRRTPGLDPDGDDAAATVQSALSANPIPLVLPDHRVDDGRGATPGAVRRRLRAIEGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C8</accession>
    <name>R4W9C8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447457.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13120"/>
    <dbReference type="EnsemblBacteria" id="AGN02563">
        <property type="protein sequence ID" value="AGN02563"/>
        <property type="gene ID" value="L593_13120"/>
    </dbReference>
    <dbReference type="GeneID" id="16180402"/>
    <dbReference type="KEGG" id="sali:L593_13120"/>
    <dbReference type="eggNOG" id="arCOG04332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_0_2"/>
    <dbReference type="OrthoDB" id="101418at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="160" mass="16994" checksum="820D894983AD6475" modified="2013-07-24" version="1">MHDTAARYQEQVDEEYDLHVTVEELPEGTHSAADAAEAIGCPLGAIVKSVVLVVEFDDGSTEPIVAYASGEHRVDVDALAEYLGAADARTASPDEVKEYTGWSIGGVPPVGHGIERTLFDESLLEHEEIWGGAGTPEAVAAFDPETVVAATDAEIARIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D5</accession>
    <name>R4W9D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13195"/>
    <dbReference type="EnsemblBacteria" id="AGN02578">
        <property type="protein sequence ID" value="AGN02578"/>
        <property type="gene ID" value="L593_13195"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13195"/>
    <dbReference type="eggNOG" id="arCOG08173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206263_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6347" checksum="B195FD01E2CA5AB8" modified="2013-07-24" version="1">MPRRYSVVCDDDLGDAVEALAREYGLTEQEVLRQLVRRGLETTDDGGNDEPSEVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D9</accession>
    <name>R4W9D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07370"/>
    <dbReference type="EnsemblBacteria" id="AGN01419">
        <property type="protein sequence ID" value="AGN01419"/>
        <property type="gene ID" value="L593_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07370"/>
    <dbReference type="eggNOG" id="arCOG02331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02386">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="324"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="535" mass="57715" checksum="014CE5287001A8A0" modified="2013-07-24" version="1">MPRLLVFGHDPESGAIAEALAGSEFDSEVVTVASREAALTTLDRQRIDCVITGYDVPDERGRTYMGGLRLLEAVREEHGDLPVVIFTDVVNEDSLRLAAANGVRAYVRDQPGEDAVGQLRYHVDSAIRGQLAERRAAEQDRINHLMRGVTQTLVLEEDRGEMLAALCSELTEQAVYRYAAYHERRETGVDPEPDSAAGSASGETSDTGLARRCVERGTVETARLRRLVGDDSETDAGATDPAAKACETLLRVAVPIGYEDERFGVLVLETDPEHAVYESETAVLAELGEAIGHALNAVETRDALEQRETELERRTEQLERFASLVSHDVRNPLNVAQGYVDLLEERSDDPAIEEIAQSLDRIEAIISDILALTRAEQELTLAPTELTVVVSDAWAAVDTPNATLEIAKGASEDGGLPRVEADASQLQRVFENLFRNAIEHGRPDEGEDAEAVTLTVHVTFDAEDGELVVADDGVGFPDGATAALFELGETGSRDGTGIGLAIVGDLLERHGWTVTAENGPSGGACFRIGGIKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E2</accession>
    <name>R4W9E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447487.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13270"/>
    <dbReference type="EnsemblBacteria" id="AGN02593">
        <property type="protein sequence ID" value="AGN02593"/>
        <property type="gene ID" value="L593_13270"/>
    </dbReference>
    <dbReference type="GeneID" id="16181212"/>
    <dbReference type="KEGG" id="sali:L593_13270"/>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115695_0_0_2"/>
    <dbReference type="OrthoDB" id="94684at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="17089" checksum="8B12F9EE37E36A98" modified="2013-07-24" version="1">MGATATPTTATPKADALRTTVLAGLVAGIVMGAIMYAGSDVLSTIGAIVGPSGAIAGWILHLLLSMGFAVGFVLLLATTPVASAFREPVDTALLGVAYGGLLAIVTWGVVIPISLLSGGSFPLGLTPSATVMARISVVLGIAHLSYGLVLGAIVATRLQPRPLFADRPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I9</accession>
    <name>R4W9I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08095"/>
    <dbReference type="EnsemblBacteria" id="AGN01564">
        <property type="protein sequence ID" value="AGN01564"/>
        <property type="gene ID" value="L593_08095"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08095"/>
    <dbReference type="eggNOG" id="arCOG09319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215168_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="50" mass="5490" checksum="8630AA2A9ADE7D61" modified="2013-07-24" version="1">MPKVACPECDRQIAMHELEANTVTESGGFSTSYRCPYCRGSIEDVADHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J3</accession>
    <name>R4W9J3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447592.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13795"/>
    <dbReference type="EnsemblBacteria" id="AGN02698">
        <property type="protein sequence ID" value="AGN02698"/>
        <property type="gene ID" value="L593_13795"/>
    </dbReference>
    <dbReference type="GeneID" id="16180840"/>
    <dbReference type="KEGG" id="sali:L593_13795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2823"/>
    <dbReference type="eggNOG" id="arCOG01070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_2"/>
    <dbReference type="OrthoDB" id="33756at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="413" mass="45464" checksum="CDD125089463FEF7" modified="2013-07-24" version="1">MAASYVIIGDGIAGSSAAETLREEAPGADITVLTDEGEALYNRILIKEHAKGKLPEAPISIHDPGWYEERDIDLWLDTHVTRVDPDAHEVHTHEGDVLEYDKLLVATGGTPNQLPVDNAGADGIHHFWTFQDARKIREHAEQADTGVVVGAGLLGIDFAAVCGAQDVDAHYLMRGECWWRYALSQEGAEIIHEGLRELGVEPVFDSGVDHFEVDDEGHVEAAVDPNGDRYEAEFAGVAIGLDFNLEFMHGTGLERDDGVVVDEYMQTNLDDVYAAGDLTRFYDTITNSYEQNGSWGSAKEQGATAGKNMAADDEVDEFRWVSSYSITHFDFPFLSFGHPTRGEEYLEQSYGEGEWRRLAIRDGQIVGGVLIGDLAPQSAYKTLAREERDVRGHEEALLEETVDPDAIAPAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K5</accession>
    <name>R4W9K5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaemetzincin</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">amzA</name>
        <name evidence="2" type="ORF">L593_13970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable zinc metalloprotease whose natural substrate is unknown.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447627.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13970"/>
    <dbReference type="EnsemblBacteria" id="AGN02733">
        <property type="protein sequence ID" value="AGN02733"/>
        <property type="gene ID" value="L593_13970"/>
    </dbReference>
    <dbReference type="GeneID" id="16180979"/>
    <dbReference type="KEGG" id="sali:L593_13970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2858"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_2"/>
    <dbReference type="OrthoDB" id="72411at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01842">
        <property type="entry name" value="Archaemetzincin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="19380" checksum="219881E16C4D89F7" modified="2013-07-24" version="1">MLVDIVPVGEVPAPVKRQASDALQSVYDCDVSVHEPQQVPASAYDDGRSQYRAEEFIELASRVGRGEKNIALTPEDLFYRRRNYVFGLAYLDGNGSVVSTYRLQTSSDGGFSERGSDEIFGDRVRKEIVHEIGHTLGLEHCDNKRCVMNFSPTVREVDVKEPHLCGSCSRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K7</accession>
    <name>R4W9K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446498.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08295"/>
    <dbReference type="EnsemblBacteria" id="AGN01604">
        <property type="protein sequence ID" value="AGN01604"/>
        <property type="gene ID" value="L593_08295"/>
    </dbReference>
    <dbReference type="GeneID" id="16181819"/>
    <dbReference type="KEGG" id="sali:L593_08295"/>
    <dbReference type="eggNOG" id="arCOG09032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143264_0_0_2"/>
    <dbReference type="OrthoDB" id="115895at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="18285" checksum="C44E8C7A271FE37B" modified="2013-07-24" version="1">MVRYETVVEDETVYVATDEDRLEIGELATIVELVGGRAWTIEYSDREKQAHPELNTADEGLTVDVVDTINAMTFGEAFVETLAAQPGASTARHGGEGDAADGGGAIDDQADGDDDIGYEEGGWGDTDDEASGGDPTGDEARGGNDIDDEADGVSPRLGLFVGRLLENLEYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P7</accession>
    <name>R4W9P7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447757.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14635"/>
    <dbReference type="EnsemblBacteria" id="AGN02863">
        <property type="protein sequence ID" value="AGN02863"/>
        <property type="gene ID" value="L593_14635"/>
    </dbReference>
    <dbReference type="GeneID" id="16180954"/>
    <dbReference type="KEGG" id="sali:L593_14635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2988"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="185"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="569" mass="62284" checksum="67B66ABC974D9632" modified="2013-07-24" version="1">MADDNWFDRRTFLKHGSVAGASIAGISLAGCTSDGDGDDDGDGDGGDDSGTDSGGGDTDGDDTDGGGGDDVPEGIMQDDYWQDLEEPSSREGYLQRANLAAHQEAPWIFLNRQYSNYGKVTSLEWTARSDELIWAYPMSPDGNSVTVTQGQMDTGLDPHAHRETPTDNIVTQAYDRLLMRTPDDEIEGALASDWERIEEGHVRFQIREGVTFHNGDELTPDDVAFSINRVVDPEVSLESPQNDQLAGVTGAEVVDGERAVDVFSDGINPVIFSLFASYCNIVQRDWIESRDTSEINSDMNGTGAFQLSSYESGESVVYEAFDDHWRGAPEFDTLEFRAASEDSTRVNQLLQGETDIVVNVPPQEVSRVQDESSTEMAPVPSTRIIYNGMKYNAEPFDDPLFRRAMNYAIDLESIVQNVLQTFADQTAQPTLEGFVGYNPDLDPYPYDPEMAEQLVEASGYAGVELELHTPVGRYLKDLEIAQATAGYVDELSNVSASVNQREFASLAGELTDGDLSTSPDWYLIGWGNAVFDASQTIIPLLTSDGALTSWQNEDFDTLVDEAQSLPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R8</accession>
    <name>R4W9R8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="3" type="ORF">L593_15020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN02938.1"/>
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        <property type="gene ID" value="L593_15020"/>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.3068"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
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    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="2">
        <location>
            <begin position="157"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="448" mass="48731" checksum="BE1BBD85848AE6F5" modified="2013-07-24" version="1">MPSDGYHRSMPVVGLDDTDSRERGMCTTYVAVRIGERLAAAGFDVQRHLLVRCNPAVEHKTRGNAALALHVRGAEETPDSAARQRCFDVARETISELAATADTDANPGLIVADTSPEAVPDEVAAFAETAVQGHHAIEDAVALADRFEYRHAGWGDGRGRIGALAAVGAWRANEDWTYERIAYRESARWGSEREVDRESVFEAAASGRTDVWDTVDRGTNTAVCVPRTPCPVLFGIRGDDPAAVEAVAKSIDSEPIDRAVTFVTNQGTDAHLQNDPDGTLEDDRAYRVPATVTSSPETREGGHVFVSVRTSRNGSPTPDEGIELPCVAFEPTKRFREHVRNLRPGDELTVCGEVSDGTLKLEKFAVRDLVETETATPVCPDCERTMESAGANQGYRCRDCGTDAPGPVERPIDRDLDLGWYEVPPVARRHVAKPLIRGGFDAPTHPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R9</accession>
    <name>R4W9R9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446608.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08845"/>
    <dbReference type="EnsemblBacteria" id="AGN01714">
        <property type="protein sequence ID" value="AGN01714"/>
        <property type="gene ID" value="L593_08845"/>
    </dbReference>
    <dbReference type="GeneID" id="16182674"/>
    <dbReference type="KEGG" id="sali:L593_08845"/>
    <dbReference type="eggNOG" id="arCOG06152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682748_0_0_2"/>
    <dbReference type="OrthoDB" id="117000at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="159" mass="17354" checksum="AA8AC200EBADDCFE" modified="2013-07-24" version="1">MTDGESWESERLETVYAETRAVIEAQQATLSDIDAKAMKTVRFNAILIGILLTAFRFAGARVFDATLLHVALGSLLVPTVVGIVTYNESRLYVGGDGEYLEWIGLDRTGGRRWDEDVIVTYTGLISENAETIDWNAWLLTVTQGMLVVGIVAAVLATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S1</accession>
    <name>R4W9S1_9EURY</name>
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        <submittedName>
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        <name evidence="2" type="ORF">L593_15045</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Natrialbales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15045"/>
    <dbReference type="EnsemblBacteria" id="AGN02943">
        <property type="protein sequence ID" value="AGN02943"/>
        <property type="gene ID" value="L593_15045"/>
    </dbReference>
    <dbReference type="GeneID" id="16181530"/>
    <dbReference type="KEGG" id="sali:L593_15045"/>
    <dbReference type="eggNOG" id="arCOG01369">
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    </dbReference>
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    <dbReference type="OrthoDB" id="35179at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="34211" checksum="2DD7DD734AC68BFB" modified="2013-07-24" version="1">MRPTPATGRHVVLGTGQVGQHVAAQLVDADADVQVVNRSGAAPDAIADEVSVQAADLSVPDQAREACADAAVVYFCVQPPYHRWPELFPPLVRATLDAADAADATFVMADDLYMYGPVEGPIHEDLPYAAAGSKGEVRAEMAETVLDAHESGRVRATIGRASDFYGPGVTGSIVGDRVFPNVLDGSTVWFPGDPDVPHSYTYIEDFARALVTLGASDAALGEAWHVPSDEPITTREFVEVAGEIVGTEPTVRELPGWILRLAGLAIRPLAELEETRYQITEPFEVSHEKFAAKFDVEPTAYREGIERTLDWYESEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X2</accession>
    <name>R4W9X2_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10020"/>
    <dbReference type="EnsemblBacteria" id="AGN01949">
        <property type="protein sequence ID" value="AGN01949"/>
        <property type="gene ID" value="L593_10020"/>
    </dbReference>
    <dbReference type="GeneID" id="16180426"/>
    <dbReference type="KEGG" id="sali:L593_10020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2066"/>
    <dbReference type="eggNOG" id="arCOG04760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665441_0_0_2"/>
    <dbReference type="OrthoDB" id="114747at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043850">
        <property type="entry name" value="DUF5812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19129">
        <property type="entry name" value="DUF5812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="16640" checksum="BAF6517040EC2132" modified="2013-07-24" version="1">MTTTVGTFLVTEADPESAILRNVEDGQLHTLSTNPDLDAGEVVEATLTAEPPMEVTWTAEIDDRRTIECEVVDLEPTTRSAEAAASLAEGELERFERAGEGEVHVLTVGADGVETAVDDVLDDEATIERAARLGAVRVEIRTGDEFLSVRYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA00</accession>
    <name>R4WA00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_10720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10720"/>
    <dbReference type="EnsemblBacteria" id="AGN02089">
        <property type="protein sequence ID" value="AGN02089"/>
        <property type="gene ID" value="L593_10720"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2210"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="486" mass="49577" checksum="009955E56AED96E1" modified="2013-07-24" version="1">MTEPGREAADDPSDPEVGAARDERIAPDRETDPDDVAETDEATYTKEGELERTIGLTGGLSIGIGTMIGAGIFVFPGIAAGEAGPAAAASFAIGAVVALLVALPASELATAMPRSGGGYYFISRGLGTLAGSVVGLSLWLGLVFASAFYLVGFGYYAIDSLAEVGIVVDAAFVVPIALLFGAGLTVLNVTGTENAAKLQNGVVALLLSLLVVFLGAGIADAVGLTGQSSAPETFAPFGAFPIVTTAALVFTSYLGFAQVATVAGEMKAPGRNLPLAMVGSVVIVGVLYVATVFVATSAFGSERLATLGETAMVEVGRNYLGAAGAIAILLGGLLATVSSANASILSTSRAVYAVSRDGVIPEWASRINLRFGTPHVALGLAGGPILLLTATGQVTVLAEVASFLHLVMYGLLCVALLALRRNEPEWYDPAYRVPGYPAVPILGAIGSFGMLAFMQLASQVIGLGIMLATAGWYAYYARDVELKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA13</accession>
    <name>R4WA13_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_11045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447048.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11045"/>
    <dbReference type="EnsemblBacteria" id="AGN02154">
        <property type="protein sequence ID" value="AGN02154"/>
        <property type="gene ID" value="L593_11045"/>
    </dbReference>
    <dbReference type="GeneID" id="16182472"/>
    <dbReference type="KEGG" id="sali:L593_11045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2277"/>
    <dbReference type="eggNOG" id="arCOG01180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OrthoDB" id="44076at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="79"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="35789" checksum="74D4080CD96EB2DC" modified="2013-07-24" version="1">MAGEFGLVEPDAVDEVGDEWPELDVSDTEADRIARERDREFDEFRKRIRDADQFKVEASVFDDATFAALYKLVQDGYIAAFGGPLSTGKEANVYEALAGDRARNVLAGEDVSATTRTAGEIEGSARQRGRSGEDPADELAVAVKVYRINASNFRDMREYLVGDPRFEELGDKQKIVLAWTRKELSNLERARKAGVRVPTPIAAERNVLVMEFVGAAGERGRRLDEVHVENPETAYEVVREYVRRLYDAGLVHGDLSEYNLLVHDGELVVIDVGQAVTIHHPNADEFLDRDCENVAAFFARQGVDADGDELAAWVRENAEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA43</accession>
    <name>R4WA43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMP-30/gluconolaconase/LRE-like region-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11805"/>
    <dbReference type="EnsemblBacteria" id="AGN02304">
        <property type="protein sequence ID" value="AGN02304"/>
        <property type="gene ID" value="L593_11805"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2430"/>
    <dbReference type="eggNOG" id="arCOG05370">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="32418" checksum="0AA0E8443DB34B2A" modified="2013-07-24" version="1">MVGRTVGTGMEPERAVDSHSLTGEGPMWHPDEQVLYWVDIPDGELFRYDPEAGENELVYDDPDAIGGYTIQADGSLLLFEDSGRVEHFDDGEAAVVIEALPGEAESRFNDVIADPEGRVFAGTMPTDDHLGSLYRLDTHGSIGRVYEDVDVPNGMGFAPDRETMYFAESEARLVHQFDYDADSGAIDEVDPFIEVDGPEVPDGLTVDGEGDVWIAFWDGGRVGRYAPDGVEREVVEFPAKKVSSITFGGEDYEDAYVTTALGEDGNAREEEGDGAGSLFRFEPGVSGVPEFRSRIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA51</accession>
    <name>R4WA51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division ATPase MinD, archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447238.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02344">
        <property type="protein sequence ID" value="AGN02344"/>
        <property type="gene ID" value="L593_12005"/>
    </dbReference>
    <dbReference type="GeneID" id="16182500"/>
    <dbReference type="KEGG" id="sali:L593_12005"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513540_0_0_2"/>
    <dbReference type="OrthoDB" id="105856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="530" mass="54430" checksum="784595D9B21D8A68" modified="2013-07-24" version="1">MSSVVAVVGTIAGAGTTTAVTALGSALGEQRQRVALVDATEEGSRLTDAIDLDGAGDLTDALRRGTAVGDVQAAGPHDIAAFPADPDTNWGAIRPNAVATLYDQLRDRFDVVLVDCGATLSPAQSAWLGHADAVTIVTDPDVAGAVPETVALAGAFDVPVRGVLANRVPPKEVDDAVEALESTDQPVLGVLPEDPTVGAAAEAGASVLRTEPDSMIATCAWELGLRFRDGDHDEPVLPMSGGPSRTASTATDDGEADDGQASEEIGETEREEAHEREPDDSAPTSDDGNDRDGQTDRDGESDASASGPARSDTADVVAEESESEPPTSTGASGTSTQGPAKSAAPVSVEGAETVASRDADESRAGGASNDPSQPRESGTDEASTADAEETTGDAASTDDTIPTDDDPFTNPEAKPAEPPTDEAASRTPLSAEKQQSGATDDGNASDGDDDSKPLDGLLGDVKERIDDDRQSRDGGQSADSATDGSSLDLETEADDDSNEDDAELSDEEIEAVFKETMSRVQERREREDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA7</accession>
    <name>R4WAA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="6">ATase</shortName>
            <ecNumber evidence="6">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="6">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purF</name>
        <name evidence="13" type="ORF">L593_13425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6 10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447518.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13425"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="AGN02624">
        <property type="protein sequence ID" value="AGN02624"/>
        <property type="gene ID" value="L593_13425"/>
    </dbReference>
    <dbReference type="GeneID" id="16179860"/>
    <dbReference type="KEGG" id="sali:L593_13425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2746"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_2"/>
    <dbReference type="OrthoDB" id="37299at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 8">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN02624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="480" mass="52406" checksum="408BFF6EDF97752C" modified="2013-07-24" version="1">MHEKCGVVGVSLADRAAARPLYYSLYALQHRGQESAGIVTHDGFQQHSQVDVGLVGDVFDEDDLENLNGENGVGHVRYPTSGSLDCSCAQPFSVSFKSGSLALAHNGNLVNADEIRDELADLGHAFTSDGDTEVIAHDLARNLLEEDLVRAVKRTMNRIHGSYSLTIMHDETVLGVRDPEGNRPLAIGELEDGYVLASESAAIDTLDGELVRDVKPGELVVLHQDGSGYDSYQLFDRDRTAHCFFEHVYFARPDSVIDEELVYEVRRNLGRALWEEEGVETDVVMPVPDSGRAFASGYAEAAQEDGADVEFAEGLMKNRYVGRTFIMPTQDERERAVRLKLNPIKSTIEGKTVTIIDDSIVRGTTSTQLVDLIRDAGAEGVHVRIGAPPIVAPCYMGIDMATREELIASNRSVEEIRDEIGADSLEYISIDAVADAIGRSRADLCLGCVTGEYPYDIDGEATDRDVTRPEIGEPTAQADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC8</accession>
    <name>R4WAC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447623.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13950"/>
    <dbReference type="EnsemblBacteria" id="AGN02729">
        <property type="protein sequence ID" value="AGN02729"/>
        <property type="gene ID" value="L593_13950"/>
    </dbReference>
    <dbReference type="GeneID" id="16182675"/>
    <dbReference type="KEGG" id="sali:L593_13950"/>
    <dbReference type="HOGENOM" id="CLU_1792208_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="14820" checksum="91F85B6D7961D52D" modified="2013-07-24" version="1">MDTDRFVEFLSTIVIVGMIAVLAVPRFGVTGLEDRLLTSAAVAIVAGGPFAVLVVYVFDVDSSHLGPWGPEDVVFVAAVAPPVAATVWAADAVGLSGTLYGVAVLAGAILSIGFAVVVRDATVGEWPPGSGAERRREAQQPSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG5</accession>
    <name>R4WAG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447808.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14900"/>
    <dbReference type="EnsemblBacteria" id="AGN02914">
        <property type="protein sequence ID" value="AGN02914"/>
        <property type="gene ID" value="L593_14900"/>
    </dbReference>
    <dbReference type="GeneID" id="16181568"/>
    <dbReference type="KEGG" id="sali:L593_14900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3043"/>
    <dbReference type="eggNOG" id="arCOG04610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2713016_0_0_2"/>
    <dbReference type="OrthoDB" id="129313at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="8084" checksum="D494C847AA97469F" modified="2013-07-24" version="1">MPKVEITVPEHLEMQIAQLVEKGEFVNREEAIEELLSTGLKAYKTSGPMDDENEPGGLEDDGMMGHDDEYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSE6</accession>
    <name>R4VSE6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00900"/>
    <dbReference type="EnsemblBacteria" id="AGN00135">
        <property type="protein sequence ID" value="AGN00135"/>
        <property type="gene ID" value="L593_00900"/>
    </dbReference>
    <dbReference type="GeneID" id="16181795"/>
    <dbReference type="KEGG" id="sali:L593_00900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.185"/>
    <dbReference type="eggNOG" id="arCOG04765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2127757_0_0_2"/>
    <dbReference type="OrthoDB" id="96414at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="113" mass="12198" checksum="8BFA359EA3833EA4" modified="2013-07-24" version="1">MSDLDAEVQDPSSVGDEGPPIAEKPYKIIFEANACFGAGKCAEVGDNWEMDILSGMAKPNSYFIAEDDLEENVRAAEVCPAKKGDGCIHVIDRRTDEEIAPDPHGDGTISVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSW2</accession>
    <name>R4VSW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445169.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01610"/>
    <dbReference type="EnsemblBacteria" id="AGN00275">
        <property type="protein sequence ID" value="AGN00275"/>
        <property type="gene ID" value="L593_01610"/>
    </dbReference>
    <dbReference type="GeneID" id="16179874"/>
    <dbReference type="KEGG" id="sali:L593_01610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.327"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_2"/>
    <dbReference type="OrthoDB" id="35407at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="32071" checksum="D1B2EDE027E456DC" modified="2013-07-24" version="1">MPTIRTNDAETYYERRGSGQPIVFLHGAILDHSQWDRQVDALSEQFTTITYDVRGHGRTGRTRRNPYSIELFAEDLGALLGGLDLEQPVLCGHSMGGCIAQVYAARHPERVAGLVLSSTFGPPVLSRSEWLQRSLGLRSTVPPVRVFGYERVEKAMVGLTELFQREASGDYDAIEALRADAPPMTTDEFVKVIRSVDSFRRSNVDLAAITMPTLVLYGENEPGFVRQHAARFAATLPDVAVERLPGSGHASNLDDPERYTETLERFLENRVDPDQSEALMDESGSEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSZ1</accession>
    <name>R4VSZ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpB</name>
        <name evidence="10" type="ORF">L593_01795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445204.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01795"/>
    <dbReference type="EnsemblBacteria" id="AGN00310">
        <property type="protein sequence ID" value="AGN00310"/>
        <property type="gene ID" value="L593_01795"/>
    </dbReference>
    <dbReference type="GeneID" id="16179947"/>
    <dbReference type="KEGG" id="sali:L593_01795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.364"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OrthoDB" id="8899at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005724">
        <property type="entry name" value="ATPase_A1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01041">
        <property type="entry name" value="ATP_syn_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="129"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="470" mass="52160" checksum="7E3594CE83D1B9B4" modified="2013-07-24" version="1">MKEYQTITEISGPLVFAEVDEPIGYDEIVEIETPEGETKRGQVLESSTDLVAIQVFEGTEGINRKASVRFLGETMKMPVTEDLLGRVLDGSGRPIDGGPDIVPDERRDIVGEAINPYSREYPEEFIQTGVSAIDGMNTLVRGQKLPIFSSSGQPHNDLALQVARQASVPEEADGEGDGDSEFAVIFGAMGITQEEANEFMQDFERTGALERSVVFMNLADDPAVERTVTPRLALTTAEYLAFDKDYHVLVILTDMTNYCEALREIGAAREEVPGRRGYPGYMYTDLAQLYERAGRIDGEDGSVTQIPILTMPSDDITHPIPDLTGYITEGQIIVDPDLNSQGIEPPVNVLPSLSRLMDDGIGEGLTREDHGDVSDQLYAAYAEGEDLRDLVNIVGREALSERDNRFLDFADRFEEEFVQQGFTTDRDIEETLTIGWELLSMLPRDELNRIDEELIDEYYEESAAEEVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT22</accession>
    <name>R4VT22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan endo-1,3-beta-D-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445239.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01970"/>
    <dbReference type="EnsemblBacteria" id="AGN00345">
        <property type="protein sequence ID" value="AGN00345"/>
        <property type="gene ID" value="L593_01970"/>
    </dbReference>
    <dbReference type="GeneID" id="16182608"/>
    <dbReference type="KEGG" id="sali:L593_01970"/>
    <dbReference type="eggNOG" id="arCOG09007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09822">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="213"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="458" mass="50002" checksum="7D11EEB4C227C23B" modified="2013-07-24" version="1">MNDESDPAESPADRSAADSDWKRRRLLGTAATAATSLIASPTAILDGESKPAIPGRIEAKNFDADGSGVAFTETTPGDSGGTYHDVDVDVEIAGDDYDVGWTDACEWRTYSATVDTAGTYEVTAKVASGADGGTFVLQQGRVHLATFEVPDTGGWQSWTTITKQVHLDAGDHVIAISLDTAGVNLDWLDFSLAGSEGAITDPYPGLDDTSWRLTWNDEFDQGSIDTSTWTFEVGGGCGEHQRHDTDCTWGNREEQYYTDGDNAWLQNDRLVIEARAELAPNGENPYTSTRLNTAGGFETQYGRIDVRARLPETQGLWPAIWMLGHDIGSVGWPDCGEVDVMELLGHDVDTVHGTVHGPGYSGSGGINDSYSGPDFSNGFHDFTVTWYPDAIKWFVDGSHYHTVTQHEVENAGDSWVFRDEFFVVLNVAVGGRFPGYPDSATQLPQRMEVEYVRVWDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTX5</accession>
    <name>R4VTX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445569.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03620"/>
    <dbReference type="EnsemblBacteria" id="AGN00675">
        <property type="protein sequence ID" value="AGN00675"/>
        <property type="gene ID" value="L593_03620"/>
    </dbReference>
    <dbReference type="GeneID" id="16180611"/>
    <dbReference type="KEGG" id="sali:L593_03620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.735"/>
    <dbReference type="eggNOG" id="arCOG00691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_2"/>
    <dbReference type="OrthoDB" id="9550at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="75"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="604" mass="63689" checksum="D20D9D12389901E1" modified="2013-07-24" version="1">MTDPADLVLTNGRVHRLAVPDPGDPRTWRGALAPDAPNDEPPEPDGSAIAIRDGEIVAIGSDRAVQWLVGIETAEIDLEGATILPGFIDAHTHLVQAGLALVHADLSVAEDREAALELLAEQAGGDADGAADWSDVDEAAESSDIDQAAESSPTHEPGDSSDVDEAAESSPTHEPEDSSDDWIVGVRYDESDWPSGDHPTRADLDRIADDRPVAAVRVDLHTAVLNSAALDLLDDPDPDDVETDDAGEPTGLVREDAVGVVEPVYDPGREATDRAVRAAIDEATRRGITGVHDKVRNSHAPRVYRDLDRADDLDCRIRIDYWADHREALAELGLRTGDGTELVQVGSLKTFTDGSIGGRSAKLRAPYADAAGDTGAAAGTESDGEAEDERGTWVVPPAELREIVDDATDARLQVQAHAIGDEAIGETIDALEASGTPAELADARHRIEHAELATDAQIERMAASGIVASMQPNFHRWARAGGLYETALGPERTARSNRLQTVTDAGVPLAFGSDGMPMDPLFGVEQAVTAPTDAQSLSVGAALVAYTGGAAFAGFDEDRIGSIEVGKQAALVALADSPWEEPESIADTHVALTVVEGRVVYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU69</accession>
    <name>R4VU69_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">pyrH</name>
        <name evidence="9" type="ORF">L593_03945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445634.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03945"/>
    <dbReference type="EnsemblBacteria" id="AGN00740">
        <property type="protein sequence ID" value="AGN00740"/>
        <property type="gene ID" value="L593_03945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180734"/>
    <dbReference type="KEGG" id="sali:L593_03945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.802"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OrthoDB" id="48934at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
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        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="25325" checksum="7FEE5FE826A26ED7" modified="2013-07-24" version="1">MNVVVSVGGSVLSPGDPERVAAHAAVVEALHDAGHEVSVVVGGGSTALEYIEVARELGANEMKLDDIGIAATRLNARLLIEAIGEAAVQTPPETYDEASVALRRGDVAVMGGVAPAQTTDAVSAALAEYVDADLLVYGTSVSGVYTADPKKDPDAEHIPEISAADLVERIAGIEMNAGAAAPVDLLAAKVIQRSGLRTIVLDGTEPERIQRAVETGEHDGTDVLPENGGADPDDWSTGSVTDAAGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU74</accession>
    <name>R4VU74_9EURY</name>
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        <submittedName>
            <fullName evidence="2">MaoC domain-containing protein dehydratase</fullName>
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        <name evidence="2" type="ORF">L593_03970</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AGN00745.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00745">
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
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        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54637"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15274" checksum="4D413ED32062CACE" modified="2013-07-24" version="1">MTEHPDGPPEVPVVGDGLTHERSFTTEEVLEYGRLTGDDQPIHTEPDEDGRLVVQGLLTGSLATKIGGDLNYVARTMEFEFRKPVYTGERITCECTVESRSEQEDRYLLEIDVEYRNDGGDVVAAGATSGVIWKQNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM9</accession>
    <name>R4VUM9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
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        <name evidence="2" type="ORF">L593_04905</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00930.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00930">
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1002"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="514" mass="57415" checksum="6E542016F1E5C029" modified="2013-07-24" version="1">MTKTIVVGLDGASWDLLDPWIEAGHLPTIERLREEGSWATNRSCYPPVTFPNWKVYASGKNPGQFGVFWFERVDLANGTIDVMEGADFDTAELWDYLNDEGHSTGVVNMPSTYPPREVDGVMIAGGPDAVEGEYRSIDSGYTYPPELAEELHERFDYDVHPDPLLSSNEETGAEVDEILRLLDLRFDVAIDALQERDLDFVHVTLFYLNVIHHFFWDAEPSLRAWQLVDERLAEIDAMEGVNLVITSDHGSMETEAEFYINEWLAENGYLTKARSAEYYFQRLGLTRERALALAKRAGAVDLLAKVVPERIQRMVPQEAGAKRGRKLEAIDLAETAAVASSQGPIYLNPDVATEETREQLIEDLRAVTDDQGEPYFPAVYRGEEVYSGEYVEDGPDVVVEQRPGIHVNDGLGGGEVVTEPDRWAAENTMTGIFLATGPDFEPRGHMDEIDMVDVAPTLLATYDVAIPTDVDGEVLDIFSEPRDPGTREPIDLDDDRGSEAGDVEDRLKQLGYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV10</accession>
    <name>R4VV10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class V aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445974.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05655"/>
    <dbReference type="EnsemblBacteria" id="AGN01080">
        <property type="protein sequence ID" value="AGN01080"/>
        <property type="gene ID" value="L593_05655"/>
    </dbReference>
    <dbReference type="GeneID" id="16181498"/>
    <dbReference type="KEGG" id="sali:L593_05655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1158"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_0_0_2"/>
    <dbReference type="OrthoDB" id="20398at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="47"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="43185" checksum="5F83635558A5204F" modified="2013-07-24" version="1">MTDDPVLRESSEPPAVGELTPPDRTLMGPGPSDVHPRVLRAMSTPLVGHLDPSFVEIMDEVQELLRYTFRTDNEWSIPVSGTGSAAMEAAIGNVVAPGDTMLVPTNGYFGGRMAEMARRAGGDVVEVDAPWGEPLDPADVEDALATHEPDVFGFVHAETSTGAKQIDVPALTEAAHDHGALVIADSVTSIGGVELRVDEWGIDVAYAGPQKCLSCPPGASPLTLNDRAMEKVRAREEPARSWYLDLSLLDDYWGDERAYHHTAPITNVYALREALRLVAEEGIESRWERHLEMAGALKAGMEAMGLGLNPADEYWLPSLNAVRVPDGVDDGAVISTLLEDYDIEIASGLGDLEGDIFRIGCMGYSARPENVIYVVNALGETLERLGAEVDAEAGRTATLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV19</accession>
    <name>R4VV19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445015.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00830"/>
    <dbReference type="EnsemblBacteria" id="AGN00121">
        <property type="protein sequence ID" value="AGN00121"/>
        <property type="gene ID" value="L593_00830"/>
    </dbReference>
    <dbReference type="GeneID" id="16182164"/>
    <dbReference type="KEGG" id="sali:L593_00830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.170"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_0_2"/>
    <dbReference type="OrthoDB" id="74433at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="26891" checksum="CA7571C229907E02" modified="2013-07-24" version="1">MATVEPVPDAPAATAWLDGERALLVADYHAGIEVALAIERGIEVESRAEERRQRLVDLVEQTRPDVLVILGDLMHSIGDPGGRERDEIEALVEALPDLPITLVKGNHDGAIEEWVPRVDVTDGAGVRFGEIGVAHGHTWPAREVLEADVVCVGHEHPQVRLEDEVGGSRVERVWLRGPMAGAPFEARDDELDWSAPELVVLPAFNGLAGGTWINVEGQEFLAPFLPEGLASGEAFLLDGTRLGDYRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVJ8</accession>
    <name>R4VVJ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446114.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06365"/>
    <dbReference type="REBASE" id="65150">
        <property type="entry name" value="SspHBORF6365P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01220">
        <property type="protein sequence ID" value="AGN01220"/>
        <property type="gene ID" value="L593_06365"/>
    </dbReference>
    <dbReference type="GeneID" id="16181713"/>
    <dbReference type="KEGG" id="sali:L593_06365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1297"/>
    <dbReference type="eggNOG" id="arCOG02634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251831_0_0_2"/>
    <dbReference type="OrthoDB" id="3686at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1444" mass="163927" checksum="B1B15719ACD8AE88" modified="2013-07-24" version="1">MSAPTVPRKAQLDKEEREHLEDVVADMRERVEDNVRFQLTQHALDDEPEDRSALDEEAEQLVEAIELEAVDGNTWGEAFEQYVTGVGYTIVNRLAALRCMEVRDFVDEEVTVFKDNGLTPAAETLVTEEFLLEDEAILQAYHDACDELAAEIEILFDRETAYSQVDPDDDTFEDLCRMLDSVPDEVWRADDVLGWVYEYYNVKLLDDLRRKGDRTGLDPEDVPPANQFYTPHWVVRMLTDNSLGKLYLEHTGELQDVVETQEALSPDERKNRPLSPDESPDIADFCTYLVPSEEEGEPTDFDHPRELRVIDPACGSGHFLLYAFDVLERIWRAETDLAPETIPRKILEHNLYGVDLDMRACQLAAFNLYLKGRTRTEAEGADGFDMPEIGIVCADATIADIDGVEAVFEEVAGDDPEVQQALERILDAFEEVHGLGSLLDVRGTLGDLFEDDAEIGGTQLTLGDDPRESHTLSQVLHSLRGAVEEHRDADSFLAQDLRSFVRLLDILAQEYDVALMNPPYGSRNRMPDSVKEYVSEHYTYKPEFYINFFEVCDTLVTREGRIGMLIPRTFMFKTSFEGFREDFVGSRGNFEFLAEFGIGILDNATVRTVGTVVRSGDSANTARDGTFIRLHDVLKGKKEEFFLRAAFEARVDGDGVTRKYTREMSEFNVIPGAPLSYWVSRDIREIYGANTVFDEGNAKVGAESLGSVNQGIASGNNDRFVRRFWETPNEDWVPFAMGGKDAWILPKLNEMLIWGNEGSELKRCESGNGTPNEEDYFTEGLTYTYIKEGGRRFGFLHEESVFSNTGFVFLPKHSLWHLLSYTNSSLLTYLMIAQTTGRHWNAGEVAKLPWAAEVGEEETLAEQAKAMLGVMLARRKEMPDSPHYEAPGLLRVLQEYSSESPFDHPHRTLLSEVASYQTEASTSRADSLWEMGIALAKHRAEIEASLETMAREIDETVFEIFGIEDTAQQDVLTEIALRTNEDPRSRNVPDPAEVQEIPDDFEQDVKDLVHHFAMEVVREEDDGIVPLQGVNGQPGMLDRIVDRFKHAYGELAEDRLIEVDEILGAESATEEAYPNLSRWIAEDLFDYHVSRMENSPIVWELTTGRLLADSTGEGFACFVDYHSLDAGLFDRLSNQYLEPRKAELRERRSAANRRRNDDSLSASEQAQAAELYERCASGLDQITVFEDVLQDLGSTDEREFDQKDRRLVEELAPKVASFREATKERVETLAALRDRNGEEWFQDTFSDNFWEAVDEWRDEWIDALEDLAYACEQYAEPADEPVEAHLADLFDYFNWRLKGSDHYSSTGILFMTYYFEREGAPLLDEDGQPFDNLTDEERNLATLAMGLDDPSIVDDEYLEEMAEEEGVEHVDDLPPLAQFKALAEEIDDRCQTIDQRIPDEWSDRALSEITTAGYQPNHKHGVEINITPLAEVEIVPKTVNEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVN5</accession>
    <name>R4VVN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446154.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06565"/>
    <dbReference type="EnsemblBacteria" id="AGN01260">
        <property type="protein sequence ID" value="AGN01260"/>
        <property type="gene ID" value="L593_06565"/>
    </dbReference>
    <dbReference type="GeneID" id="16180844"/>
    <dbReference type="KEGG" id="sali:L593_06565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1339"/>
    <dbReference type="eggNOG" id="arCOG02601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114810_0_0_2"/>
    <dbReference type="OrthoDB" id="63240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="196" mass="22399" checksum="29A1A775B4E2EDAC" modified="2013-07-24" version="1">MAPGTRAHVLIVEDRPEIARLYESWLSEDYDVSVSHDGDDAVDTFDQSVDVVVLDRRLPGRPGDEVLQAIRDVSDCSVAMATAVEPDFDILEMGFDEYVVKPLTRGELIGTIERLLARDNYADSLQRYFALVAKRSVLEEHKSSAELDDDRYREFSEQIDDLEADLEHCVDRFEHRDFEALFRSLDDTEEADPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVR6</accession>
    <name>R4VVR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446189.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06740"/>
    <dbReference type="EnsemblBacteria" id="AGN01295">
        <property type="protein sequence ID" value="AGN01295"/>
        <property type="gene ID" value="L593_06740"/>
    </dbReference>
    <dbReference type="GeneID" id="16181854"/>
    <dbReference type="KEGG" id="sali:L593_06740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1377"/>
    <dbReference type="eggNOG" id="arCOG03029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2243747_0_0_2"/>
    <dbReference type="OrthoDB" id="115656at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043952">
        <property type="entry name" value="DUF5783"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19095">
        <property type="entry name" value="DUF5783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="12427" checksum="ADA4012161C72BC6" modified="2013-07-24" version="1">MSDLDPETFDERKYVEDFPKLQRAYKNAFETMNDAYNSELVHAIDQQVLAESEPFYEGDGEFRIELPEDPYDRLEGTLVDEETFQDTLERYVEELKDEIARTFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW17</accession>
    <name>R4VW17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07325"/>
    <dbReference type="EnsemblBacteria" id="AGN01410">
        <property type="protein sequence ID" value="AGN01410"/>
        <property type="gene ID" value="L593_07325"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07325"/>
    <dbReference type="HOGENOM" id="CLU_3039220_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="5539" checksum="2AB9492B27FBBFE4" modified="2013-07-24" version="1">MTTLGQKALAIAVVAGISLVFVAISLALGSGFLLFVAVGFATLSAMFVLRLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW78</accession>
    <name>R4VW78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Elongation factor 1-beta</fullName>
            <shortName evidence="7">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ef1B</name>
        <name evidence="7" type="synonym">ef1b</name>
        <name evidence="9" type="ORF">L593_02875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445420.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02875"/>
    <dbReference type="EnsemblBacteria" id="AGN00526">
        <property type="protein sequence ID" value="AGN00526"/>
        <property type="gene ID" value="L593_02875"/>
    </dbReference>
    <dbReference type="GeneID" id="16180363"/>
    <dbReference type="KEGG" id="sali:L593_02875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.581"/>
    <dbReference type="eggNOG" id="arCOG01988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165896_0_0_2"/>
    <dbReference type="OrthoDB" id="124073at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="8">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9164" checksum="7563F60BD6232173" modified="2013-07-24" version="1">MGKVAAQIKVMPESPEVDLDDLEERLADSLPEGAEINGIGRDDVAFGLVALLPTVIVADGAGGTEPVEEAFASVDDVESVEVQETGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWF2</accession>
    <name>R4VWF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08125"/>
    <dbReference type="EnsemblBacteria" id="AGN01570">
        <property type="protein sequence ID" value="AGN01570"/>
        <property type="gene ID" value="L593_08125"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08125"/>
    <dbReference type="eggNOG" id="arCOG02698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791357_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="350" mass="35949" checksum="EA81A41E1EE4109D" modified="2013-07-24" version="1">MGGLLSLGGVSVLGGTQAFSQTDATRGTAVQTAGDRNALLGVDPVASVQTGTDGQDLVTLTNNIDAVLDVTISLDDPSQGSVSPSTATIASGASTTITVDVAADSPTGTDALPFTVSATDGGDFSVSLTRTVDVEAGPQLLRHVADQSRNNTAQYTVQFDVNGVSDFDRVEVSFVSRDNNWASGSSTATTPEGSVSYSEGGAMGDTYDITIDVYDTSGSIVLSETVTDVADGSNPSGNDDLGGPNSPELDSFSLQDTTRRNSTDFDLDYEVSNLTNFQEVRVTFENRDNSWATDTKTDTSAPTGSVSYSAGGTQGDTYEITVAVVNDSGITVDSGSITHVSGSSSSASWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX90</accession>
    <name>R4VX90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HpcH/HpaI aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04660"/>
    <dbReference type="EnsemblBacteria" id="AGN00881">
        <property type="protein sequence ID" value="AGN00881"/>
        <property type="gene ID" value="L593_04660"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.952"/>
    <dbReference type="eggNOG" id="arCOG00760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800782_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="4">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="372" mass="40066" checksum="95597E40FC5E24C1" modified="2013-07-24" version="1">MTDETPTTAPTDDSDTDSMTQRLCRTFQTAPVAVAGDDTAKYLRSGLTASGFQAPDWLVPDLEDGTAPAKKEEGLENLLDLLPEYAPDFPGEIFPRVEWAYDDPATAERGREQIDRIVADAGEHVDGIVVPKVGRLADVEAALRAVAEAEALYGYDEGSIEVALIVETARARSDLREIAALGSGNRDEASDAPARLAGLVFGPVDYTAELGGRSRDGERSTWPALLEALSNEASANGIVSVGGPFDRLFAERAGITYYNAPGYADQVEREAAVGLDGSWSLHPKQTTQANRIHMPTPAELERDVEKIERFAEAKTAGTGAVSIDGQMVDEATLKNFQNTVRTVRAIADRQPEQAKSVYETALLERAQSVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXA5</accession>
    <name>R4VXA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445790.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00896">
        <property type="protein sequence ID" value="AGN00896"/>
        <property type="gene ID" value="L593_04735"/>
    </dbReference>
    <dbReference type="GeneID" id="16181070"/>
    <dbReference type="KEGG" id="sali:L593_04735"/>
    <dbReference type="eggNOG" id="arCOG04746">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003327_0_0_2"/>
    <dbReference type="OrthoDB" id="76189at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="30184" checksum="9281BD0E1D50C9AA" modified="2013-07-24" version="1">MQGRAAAVYGLVFLLVAAGAYGFVTVAEAPEPSMDNPDVTFAETGENQTIGERTYRLDGFGSQRGQPTATLVWTDEDARSTESWTHAAEPGGTTVTTAENVTYWVRIPQDEATGSFTLLETPAEGSNVTVVTDSNGNWVVEEGTNYTALEEYDGFERVEVENGSTLAIGTGNDTRDVRVDQVTNESVTVSWNEPAETEITLRQTSVKELEGTNVTVHVPGDGSLEMATSEEPIDDYLEQHEDRTHFQERMDGLKMSAVLSLVSFVLLVGMAFLPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYI6</accession>
    <name>R4VYI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446185.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06720"/>
    <dbReference type="EnsemblBacteria" id="AGN01291">
        <property type="protein sequence ID" value="AGN01291"/>
        <property type="gene ID" value="L593_06720"/>
    </dbReference>
    <dbReference type="GeneID" id="16181861"/>
    <dbReference type="KEGG" id="sali:L593_06720"/>
    <dbReference type="eggNOG" id="arCOG03633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053152_7_0_2"/>
    <dbReference type="OrthoDB" id="105475at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14740" checksum="46CF49BE553ADFE0" modified="2013-07-24" version="1">MREDGELGGIGSRAVAVIVDTVVLFVVGYLIAMATGSTTGSGFALQGLPALLWFGAGFAYYIVLEAEYGQTPGKRLVGIEVVGEDGGPIDYQASVIRNVLRFVDALFFYLVGAILIWISDEGQRLGDRVGDTYVVKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYK4</accession>
    <name>R4VYK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fla cluster protein FlaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447234.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11985"/>
    <dbReference type="EnsemblBacteria" id="AGN02340">
        <property type="protein sequence ID" value="AGN02340"/>
        <property type="gene ID" value="L593_11985"/>
    </dbReference>
    <dbReference type="GeneID" id="16181988"/>
    <dbReference type="KEGG" id="sali:L593_11985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2466"/>
    <dbReference type="eggNOG" id="arCOG04148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094838_0_0_2"/>
    <dbReference type="OrthoDB" id="60868at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="27940" checksum="E2204F999537E090" modified="2013-07-24" version="1">MSGRNLVPLGLDDRDRLNAELGGGIPRGSIAIMEGQYGAGKSALTQRFTYGICEEGHTVTFLSTELTVKGFIDQMHSLDYGVEDHLLDERLLFLHGDIDSSSALRGDEEDEGERMQLLKRLMDAETMWESDVIILDTFDAILRNDPKFEHLVRQGDERQAALEIISFFREIVAKGKIVILTVDPTAVDEEAMGPFRSIADVYLELQMIEVGNDVRRNIAVKRFTGMGEQVGDSVGYSVRSGIGIVIESRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYU7</accession>
    <name>R4VYU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446310.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01416">
        <property type="protein sequence ID" value="AGN01416"/>
        <property type="gene ID" value="L593_07355"/>
    </dbReference>
    <dbReference type="GeneID" id="16182104"/>
    <dbReference type="KEGG" id="sali:L593_07355"/>
    <dbReference type="eggNOG" id="arCOG14169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911692_0_0_2"/>
    <dbReference type="OrthoDB" id="144544at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6412" checksum="5B95319DA1276DB1" modified="2013-07-24" version="1">MTTEFDLGCATCGGALQERSVDAESLGVGGEGTVPVAECPECGDRYVPEQTLHRIGGRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ54</accession>
    <name>R4VZ54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447444.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13055"/>
    <dbReference type="EnsemblBacteria" id="AGN02550">
        <property type="protein sequence ID" value="AGN02550"/>
        <property type="gene ID" value="L593_13055"/>
    </dbReference>
    <dbReference type="GeneID" id="16180366"/>
    <dbReference type="KEGG" id="sali:L593_13055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2676"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_2"/>
    <dbReference type="OrthoDB" id="21408at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="350" mass="37690" checksum="605F5385ECD2C7AC" modified="2013-07-24" version="1">MEAFVMRSIGVTGIVEKERPEPGPMDAIVRPTVGLICTSDCHTVHGAIGDREDLTLGHEAVGIVEEVGDHVERFEPGDRVAVGAITPDWNSTAAQDGHPSQSNQALGGWKFANVKDGAFADYFHVNDADGNVAHIPDGVSDHEACYTADMLSTGFAGAENADIPMGGTVAVFAQGPVGLMATKGARLQGAGEVIAVETMENRKELAREYGADHVVDFQEGDPVEQIMDLTDGEGVDSAIEALGADETLKDCIRATKPGGTVSNVGYHGEGEFRHIPREEWGVGMAEISIVTDLCPGGSLRIRRLLRMLEQDRVDPTKMTTHEFDFDEIETAFDMMDEKSDDIVKPLIHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZB7</accession>
    <name>R4VZB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447514.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13405"/>
    <dbReference type="EnsemblBacteria" id="AGN02620">
        <property type="protein sequence ID" value="AGN02620"/>
        <property type="gene ID" value="L593_13405"/>
    </dbReference>
    <dbReference type="GeneID" id="16180591"/>
    <dbReference type="KEGG" id="sali:L593_13405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2742"/>
    <dbReference type="eggNOG" id="arCOG00796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370740_0_0_2"/>
    <dbReference type="OrthoDB" id="9523at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="436"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="837" mass="91768" checksum="CF224CA79C0B56EC" modified="2013-07-24" version="1">MEDALDAIKAQVDGMETRPAVFDRELRQRFDRWRLADPVPAEEIIERFARHGGFDGDGATVRIPLHEVDSAELTGEYLLYHPEHVVECVGFYEYEKGDLTHIRIEDFAETFPAWRLRFWHHSNAPPSQPSYLKESTDLADESAAPGSSVAGLQSVDGEDLFDQLTAFVEREKEAEREQTRRHFADLSAEQFFAEFGGVSGVEPAGREVGEYGEQIVTLRVPGEDQDDDDGVPGGDFDTAGNGDDTAEDPTAGGARYDNWEELAEAAGMSPDEVREERKAAINGEGEADGDATGAGDPSSAATDDFDFRAAGLYPGSEVIIGHERGGRGFPVEAELYEVEGRTMRLGVYWRQTEDKAAAEAAFKADSDATFVVGELLNVVPFDRQWDAIETIQADDRKSDVLTGRRDVGFRDATEVDVRTGDLNEYQARACTSAMRAEDVFCIHGPPGTGKTRTLTKLIREAARDHQRVLAVAHSNQAVDNLLVGSSTTEQADPRSLHALAQDDELSMARVGSNCDHPVVEEEYVGEDHWQADVVGATMSAAHQFPDDLFDLVVVDEATQATIPATLIPVSKGERAILAGDHKQLPPYHSGEYADREEMEKSLFEHVLEVYGDDIATTLATQYRMHEDIAAFPNDAFYDGILTHASRNRDWTIGTLDPLVGVDVTGSEERTPRESLYNPAEVDAVVAEIDRLLRYGVDPADVGVITPYTGQVAKIRSALASHDPPGLHHDVTVNTIDAFQGSESEVIVVSFVRSNDAGQIGFLDFPNEGPRRLNVALTRAKKRLVLVGDWDCLTTLPGRRDPADSATPVYQNLHQHLLDHASVETVGEIEGDAVGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZD2</accession>
    <name>R4VZD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase PA-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446510.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08355"/>
    <dbReference type="EnsemblBacteria" id="AGN01616">
        <property type="protein sequence ID" value="AGN01616"/>
        <property type="gene ID" value="L593_08355"/>
    </dbReference>
    <dbReference type="GeneID" id="16180726"/>
    <dbReference type="KEGG" id="sali:L593_08355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1712"/>
    <dbReference type="eggNOG" id="arCOG03058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061498_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="33893" checksum="03F40A81578E90D5" modified="2013-07-24" version="1">MSRSLGVVELIHSLLPDQSALLLGLLTQLGDVWFLFGATVVTYLFRPRDRERVAVVLGLALSTAALVEALKAVFALPRPTTPLATAELYPAALRGIFEATATGGGHGFPSGHATLSTVVLLGLAGAVRVGDARWRWLLAGGLVALVSLTRVALGVHYLVDVVAGVLIGLTVLAGVAWATEASPLDRPTTAFVIAATVGVAGVLVTAPTLGLDGSARPPHDSVVALGAALGALAGWQGLRLRATGTADPVAPDGDRLDTERWPPLRALLAVGPMLALLALVITGLVVGDEAAATAGLAGIGFGFAVALPVLVPEFDRLVAGYVPQWFRGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZI9</accession>
    <name>R4VZI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446560.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08605"/>
    <dbReference type="EnsemblBacteria" id="AGN01666">
        <property type="protein sequence ID" value="AGN01666"/>
        <property type="gene ID" value="L593_08605"/>
    </dbReference>
    <dbReference type="GeneID" id="16182475"/>
    <dbReference type="KEGG" id="sali:L593_08605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1762"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="25333" checksum="9BEB8676DB33298A" modified="2013-07-24" version="1">MNVLVTGGSRGIGRATALALAGEHDVAIGYNESADAAADVAAAARDRDAAAVTVQADVTDSDAVEQMVDTAADELGGLDAVVNNAGIVDPGRLDDLDDEQWDRVLRTNLTGAFYVTRAAIEYLQPGGDVVFVSSIGGTAGTVDASYAASKAGLHGLTRALAREYGEDGVQVNAVAPGPVETSMNDDILAFLEAIEFRGHENLDTHLPEYACDPSEVADTIEYLLGNEYVQGEIVNVNGGMQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZU3</accession>
    <name>R4VZU3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <begin position="36"/>
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            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="127" mass="13307" checksum="968FC7D87B986A78" modified="2013-07-24" version="1">MMTGASSPPEDARRASRSVAIDGAEPSFRAVKAASVVLLLGAVLDTAVGLGVIGTSPIPGALLLGIGVSECYLAYGLWHRQRWGLRGTLLTQGVAIVPLVVLGTMLATAPKLALLGYLLWLRNADWR</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="90" mass="9836" checksum="5C808D83A4C5091D" modified="2013-07-24" version="1">MKGDTALQWSMSATAAASTASLSDKQHQILGYLREKAPMKTYFKSRLIAEELGMSAKEVGTNMTAIADGDLDVDVERWGYSSSTTWKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZY6</accession>
    <name>R4VZY6_9EURY</name>
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            <fullName evidence="7">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="36300" checksum="A2B0DABEA7ADFDB6" modified="2013-07-24" version="1">MQAQPAPEPEPSEPGSSRRRLPILGTIAVLVLGGLVAARTVDLGEAVDAIRAADPLLLAAAILVYALSWPLRGRRYGDVLAPMDRRLRTGFLTSAVLLSQTANLAIPARGGDAVRAVVLKRRRAVAYATGVASLAVERAFDLLAIGALGGVALAWLVLAGDAAPVFDGLRSLDLPVALFSGAAAGIGLLLAAGAVLAYRSSSAALDLLPDRLRDGVATAASNLAVLVRRPRALAAVGLGSVAIWALDAVTAVLVLAAVANPDPLALLAVGTLAVCAGNLAKVLPLTQGGVGLYEGAFAATVVALSPIAGSLALAAALLDHALKNGVTLAGGALAGLVLHRSSASETGDSTRTGNLLGWPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZZ6</accession>
    <name>R4VZZ6_9EURY</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02830">
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    </dbReference>
    <dbReference type="GeneID" id="16181321"/>
    <dbReference type="KEGG" id="sali:L593_14455"/>
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    <dbReference type="eggNOG" id="arCOG04564">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="77"/>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="39347" checksum="E95CC4911F07AC75" modified="2013-07-24" version="1">MRSTLRTGTTALTTAIAIFLASTPVAAHVRYTAPSNGSVSPAELFVNVVTDPFNAALLGGGALAVGIAALAYLRFLPFRRDISVFREAVAEYRDLLPWLLRLSFGLPLVGAGFAGYFVSPAVEPAGSVLPAAARLFQIGLGFALLFGLGTRVVAAIGLATYAVATVFEPQLLLAFEYVPGFVAIVLLGSGRPSADEVLEVVASAEGTVYGRIDPVHRLTGSVRARVGPYQRFVPTVIRVGIGLNFAYLGLIEKLLTPGQALAVVDKYDLTAVVPVDPGLWVVGAGLVEIALGIVLIVGAFTRAGSLVALLMFTLTLFALPDDPVLAHISLFGLASTLLVTGAGPYSLDRWIGERFTTPSAGRDGRIPKEDADLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W029</accession>
    <name>R4W029_9EURY</name>
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        </submittedName>
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    </gene>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14645"/>
    <dbReference type="EnsemblBacteria" id="AGN02865">
        <property type="protein sequence ID" value="AGN02865"/>
        <property type="gene ID" value="L593_14645"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="20"/>
            <end position="41"/>
        </location>
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            <end position="172"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="70"/>
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    </feature>
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        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="37995" checksum="B6FCBBF054C5258A" modified="2013-07-24" version="1">MVSDRTWRNLRAELRRSHLAKLGVLLVLFIVTAAILAPVLAPHDPTKTNPEDSNLPPLGFSETKNQSTSQMVDGEIQIVEEKVEVNAKSEHPLGTDHVGRDVLSRVLFGARTSLVVGIIGTALAALFGVSVGLVSGYYGGRVDDGFMRAADIMLAFPSLVLAIALVGIWGQQSYEIPDPFHALGITPDMPEATVVPGTVIIVVALVNWVWFARVARGEALRVRNEEYIKAARASGMRDVEIGSVYVFGRRLPFPRGIVIQHVLPNSVTPIIVLATIQVAAIILLESALSFLGFSGANLSWGIDISQGRNYLSSSWWIATVPGVAIVIAVVGINLLGDWLRDALDPGIDQGEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W090</accession>
    <name>R4W090_9EURY</name>
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            <fullName evidence="3">N-methylhydantoinase B/acetone carboxylase, alpha subunit</fullName>
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        <name evidence="3" type="ORF">L593_09780</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="20"/>
            <end position="548"/>
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    </feature>
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            <begin position="536"/>
            <end position="558"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="580" mass="60186" checksum="37EF0F8239DDFB43" modified="2013-07-24" version="1">MSDEPGADEHVDAAGGTDVDPVTLEVLRNAASAVAEEMNATLLRTAYSPNITDRRDCSCAIFDPDGGMIAQAENIPVHLGAMPFSVAAALEEHPPETLEPGDGIAVNDPFRGGAHLPDVTLVTPVFHDGALVAFAANRAHHADVGGATAGSVSAESTEIYAEGIRVPPVRLLKGGAFDDDLLATILANVRTPEERRGDLRAQAAANDVGRERIGDLIAEHGAAGFAEAVDAIQDYSERRMRNAIADLPDGEYAFADVLDDDGHGTDDVRIEATVTIDGETLAVDFAGTAEQTESPINAVRAVTASATYYAVRCVTDPEIPPNAGCYRPVELRTPSGTVVDAESPAAVVGGNLEVSQRVTDVVLGALAAVAPERAVAAGQGTMNNVTLGGTDPRDGSAYAFYETQGGGSGAHAAGDGMDAVHVHMSNTRNTPAEVLETAYPLAIERYELLADSGGAGEFRGGLGLRRDIRVERGAAQLSLLGDRREHAPYGIEGGDGGSPGTDVLLESSDAEGVVGRSSEVLPSKCTRRLDAGDVISIRTPGGGGFGDPADRDPESVVRDVRLGKCSPERARDVYGVDPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Y9</accession>
    <name>R4W0Y9_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02201">
        <property type="protein sequence ID" value="AGN02201"/>
        <property type="gene ID" value="L593_11280"/>
    </dbReference>
    <dbReference type="GeneID" id="16182410"/>
    <dbReference type="KEGG" id="sali:L593_11280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2327"/>
    <dbReference type="eggNOG" id="arCOG03392">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089194_0_0_2"/>
    <dbReference type="OrthoDB" id="90412at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="21233" checksum="B6819825E066C034" modified="2013-07-24" version="1">MWPWEHVAAAYLGYSLFARIVYRRAPRGDAVLAVTIAALLPDLIDKPLAWGLHLLPSGRSLAHSLLFAVPAMALSALLTGRRVALAFALGYCSHLAGDVVYPMALEQPAAYRFLLWPLVEQPTTDTPGLLFRVQHLFVEFLGFLQTTRGRLYVVFEGALLGTAVLLWLLDGRPGPGTIWSWMRPGREKPRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1C9</accession>
    <name>R4W1C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447290.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12275"/>
    <dbReference type="EnsemblBacteria" id="AGN02396">
        <property type="protein sequence ID" value="AGN02396"/>
        <property type="gene ID" value="L593_12275"/>
    </dbReference>
    <dbReference type="GeneID" id="16179838"/>
    <dbReference type="KEGG" id="sali:L593_12275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2525"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_2"/>
    <dbReference type="OrthoDB" id="52579at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="235"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="398" mass="41923" checksum="3A371F6D9D4E7ED4" modified="2013-07-24" version="1">MTRPNATGVVGAGLMGRDIAGLLANGGFPVTLVDVDPDALALARDYHETELVDALADAGFDPDGARDTGDDEATGGARDTGDDEATDDSVDAGAGLLGHIEYDTDLAALGDCEFVVEAVPERLELKRDLLADLETVLGDDAVIGTNTSSLTPGEIAADAAAPERVVLFHFANPALERDIVEISGDDATDHALSTATDVAEAIGRTPILLDAEYRANCLSRLSASIKCAGTWELLEAEAAAIDRGAAAIGFDRGPIEFVDLIGVDVHLATVDNLGEAYGDRYAPPPAIRERMEAMVQAGDCGKKSGRGFFEWDGDACRLPEVDEPHDVTPVVGALVNEAHRLVEDGVGDEDTIDEVLRRGSGGEIGPFDVESMLGREFLREALEERYAETGAAVYDPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1K8</accession>
    <name>R4W1K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mut/nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12835"/>
    <dbReference type="EnsemblBacteria" id="AGN02506">
        <property type="protein sequence ID" value="AGN02506"/>
        <property type="gene ID" value="L593_12835"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2633"/>
    <dbReference type="eggNOG" id="arCOG01072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="21272" checksum="7B0C967310FA9857" modified="2013-07-24" version="1">MRLDLSAVVGCDPTVIRDQPRDAAVLAPVIERDDGHSLLFIKRSEDLGEHPGQMSFPGGGAEPEDVDLQATAIREADEEIGLDPEEARILGRLDAIRTVTDYAVSPFVGMVPDREYAPDGVEAIEVAILSVADLTDPANYEFETRDHPTYGEVVVHYFHVDGYTVWGATGRILVDLLELTTDWRAPVRSRSDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1N8</accession>
    <name>R4W1N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13035"/>
    <dbReference type="EnsemblBacteria" id="AGN02546">
        <property type="protein sequence ID" value="AGN02546"/>
        <property type="gene ID" value="L593_13035"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2672"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="23731" checksum="26B5924257C7CDD7" modified="2013-07-24" version="1">MRELFVRARSEPLISGASGLADMSDDELAWETLSSEVAYECPGFEIVHDDVRLPDGTETDYDYLTEPPAVVVLPFVADDATSAEIDADDREVVVIEEWRQAVGRLNRGIPVGSVEPEDDDLTLGAHRELREETGYEADSVEHVLTTEPVNGIANSVLHYFVAEGCTPTAEQDLDANETIRVDTASLADLRSAALADDLRDGRAVTALQHHALRERGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1Q3</accession>
    <name>R4W1Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific recombinase xerd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_13135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13135"/>
    <dbReference type="EnsemblBacteria" id="AGN02566">
        <property type="protein sequence ID" value="AGN02566"/>
        <property type="gene ID" value="L593_13135"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13135"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053274_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="42804" checksum="6596ABA53AF8663F" modified="2013-07-24" version="1">MLPDDVPLVTGPAEERLSDRQLVDYRNHREDFLTWLYAFGKDPESAVGYSADTVLRTAYRVDQFYRWVWDQRGYTSSPSSEDADAYVRDLAMGEESNTHKSNTLSALKRLFKWREYERGGDSWEPEFTFSRNSPASQPRDYLTREERNQLREAALEYGSIPAYNDLSPDARTRWKRYLAQRFEKPMEEVVPADWSRANGWKIPSLVWVSLDCGLRPIEVERATTSWVDTENGVLRIPKEESSKNRDNWTVGLTDRTSDSLRRWLSERQNYSEYHGREALWLTREGNPYRSQSLRYVLQRICEEGDIATSDRSLSWYSLRHSVGTYMTREEGLAAAQVQLRHKSETTTMKYDQAPVEDRKDALERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W248</accession>
    <name>R4W248_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447605.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13860"/>
    <dbReference type="EnsemblBacteria" id="AGN02711">
        <property type="protein sequence ID" value="AGN02711"/>
        <property type="gene ID" value="L593_13860"/>
    </dbReference>
    <dbReference type="GeneID" id="16180891"/>
    <dbReference type="KEGG" id="sali:L593_13860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2836"/>
    <dbReference type="eggNOG" id="arCOG02827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800808_0_0_2"/>
    <dbReference type="OrthoDB" id="48454at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="32717" checksum="2A56BBA254B40B71" modified="2013-07-24" version="1">MTGLADAYTDDVGGLQTDTRLKAGVALLAVGTLLGLLAVVVAIANPTEWGARRVAGALGLLAAPALAGGVVVILPANPRLRAAAAIGASLTLLGVASFWHAYPQHWLGHGDQLTPYVTAIYFLGMLTIALCLFAGIATFKRRNDPGGTVSLRVGEGKTKYVEVEADNEESALGGGVGLLGGTPDGSVETQTNRPEKRDAESSHSRSANDDATVTRSSGSGRSGGTSSTGRTSTTRSNPATGLGTASDGGSGTETLASPQPKPDAGSDRSADVADKYCGNCEHFSYARTEQGMTPYCAHRSEYMDDVEACEDWSPNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W261</accession>
    <name>R4W261_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdgB/HAM1 family non-canonical purine NTP pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447620.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13935"/>
    <dbReference type="EnsemblBacteria" id="AGN02726">
        <property type="protein sequence ID" value="AGN02726"/>
        <property type="gene ID" value="L593_13935"/>
    </dbReference>
    <dbReference type="GeneID" id="16180962"/>
    <dbReference type="KEGG" id="sali:L593_13935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2851"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OrthoDB" id="94889at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22200" checksum="6C5C662432044DCD" modified="2013-07-24" version="1">MLRFVTGNEGKVEEAREYLPMAVEQTDYDYVEVQSDDLAPIAARGARESFRELGGTEPVAVEDSGLFVDALGGFPGPYSAYAEYTLGIERVYRLVEPEDDHRASFRSVVAYAADADSLDEDVTDDDPDWHDGVTVEDGVAVATFEGTVRGEIVTPRGDGGFGYDPIFEHEGRTMAERSTAEKNAISHRGRALAKLADWLAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2B8</accession>
    <name>R4W2B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02811">
        <property type="protein sequence ID" value="AGN02811"/>
        <property type="gene ID" value="L593_14360"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2941"/>
    <dbReference type="eggNOG" id="arCOG06319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="520" mass="59970" checksum="D9EDD82419C28E8C" modified="2013-07-24" version="1">MNQLADLHADRSDPIAERGTLYDRALTYWREHVGDHEREPHVAVEEFEADWLPEGEYALVLTSSRWKAGTGRGDNYSAYYEQHLKLRRWAQNADGEEVLRKPPVALHVEIMPQFRDMVYKSGDPLECPHGEGTRLIGWSTYAESAFEIERRMYDALRAVYGRDAIDLDDRVHDSRRIAKAEAHIRFDIEKKAAAVETIDQTRQLIDWGGEAEIEAHQRRQQEGWLESKLESDRWHMLGFEPQEYSTELKVYQASQWSKRPRSDPLHHPKMEASYAGVDRGELPHVEEWDEVLGHLRTVVATHGRWAGIERGDLVADDFFDGDTAPPFDYERPTGRRSMLQRRYEDLATEIYREALKESTTAVYDILRVVAEETGATYDTLEDRTGLARSTVRYHVARLAEAGVVKRLGNPVLVAFVSRVVLEQAREIVREVRPDDLAEDMNERAEERRERREELREQDATEGDDEPDRGPVGGEEADRIGFEYLASLSATLSDVVLEYDRDELGDQDVRVRVDELPSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J8</accession>
    <name>R4W2J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HalX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447815.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14935"/>
    <dbReference type="EnsemblBacteria" id="AGN02921">
        <property type="protein sequence ID" value="AGN02921"/>
        <property type="gene ID" value="L593_14935"/>
    </dbReference>
    <dbReference type="GeneID" id="16181587"/>
    <dbReference type="KEGG" id="sali:L593_14935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3051"/>
    <dbReference type="eggNOG" id="arCOG02599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114810_0_0_2"/>
    <dbReference type="OrthoDB" id="63240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="21890" checksum="9382D435A28AB53C" modified="2013-07-24" version="1">MSEDAPEILVVDDEARLADLFAAWLQADWSVDTAYDGEEALEKMGDSVEIVLLDRRMPGLSGDEVLQRIREDGYDSRVVMVTAVDPDFDIIEMGFDDYLVKPVSKDDLVDIVERIQTRSTYEADIQEYYSLVSKKSLLESEKSERELEDNAEYQELVERVEQLEDKVDHSVGQLSDHDDFVGAFQDLPGSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2P2</accession>
    <name>R4W2P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444956.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00535"/>
    <dbReference type="EnsemblBacteria" id="AGN00062">
        <property type="protein sequence ID" value="AGN00062"/>
        <property type="gene ID" value="L593_00535"/>
    </dbReference>
    <dbReference type="GeneID" id="16181721"/>
    <dbReference type="KEGG" id="sali:L593_00535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.109"/>
    <dbReference type="eggNOG" id="arCOG08131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061327_0_0_2"/>
    <dbReference type="OrthoDB" id="81200at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="36697" checksum="252BDDB466F7569B" modified="2013-07-24" version="1">MADLTTADRMRERTDVNRVWFWLLLGANRWVVTAVLGALVFGTFMGWGITKSTSLQATMQASDMVETVFAGLVGAVITVSTLVVSINQLVLSQEIGSLGSQRSRMDVTMDFRESTDDLLGETTPADPAAFIDALIAESEERAQRLREAIDESEHPELGESVDTYVADLLENADHARKLLVDSDFGTFDVVQPALDFNYGQKMHDVRRLGREHEDELTEKQLAAFREVLVSLTMYGPVREYVKALYIQWALVKLSRAILYATVVALTVAGGMVVFVDATTFTGRLFGVETILWVVSAAFTISTLPFLVFTSYILRLATLAKQTLTVEPLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Q6</accession>
    <name>R4W2Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444981.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00660"/>
    <dbReference type="EnsemblBacteria" id="AGN00087">
        <property type="protein sequence ID" value="AGN00087"/>
        <property type="gene ID" value="L593_00660"/>
    </dbReference>
    <dbReference type="GeneID" id="16181950"/>
    <dbReference type="KEGG" id="sali:L593_00660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.134"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_6_0_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="134"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="369" mass="38986" checksum="69FBD2C00E6CACE1" modified="2013-07-24" version="1">MDPVSVGLLGCGTISDAYLSSDDRFDSFEFVACADVDPNVAAETAAEYDLEARTPAELREDPAIEAVVNLTPPAAHAETVERLLEAGNHVYVEKPIAATVDDADRIVDAAESSDLLVGSAPDTFLGAGLQTCRSVIDSGRIGEPIGATAIWTSGGHESWHPNPDFYYHEGGGPLFDMGPYYVTALVSLLGPVERVTGSVSRAFDERTITSEPRASETIDVEVPTHESGVLEFADGTIANLTTSFDVPGGSTLPSPAFEIYGTDGTLALPDPNHFEGPVRVSDHDTDGFEEVELTHEYTDGRGAGVADLAMAIRGDWEHRTGAGLANHVLSVLSGVRAASERAEHVAISDADVGRPEPLPASFPDGNRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2S0</accession>
    <name>R4W2S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00785"/>
    <dbReference type="EnsemblBacteria" id="AGN00112">
        <property type="protein sequence ID" value="AGN00112"/>
        <property type="gene ID" value="L593_00785"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00785"/>
    <dbReference type="eggNOG" id="arCOG09024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159740_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="10313" checksum="13F0E32A0E51CCC8" modified="2013-07-24" version="1">MGGVDHTHPDRNTTFGSIFGRGPSVAADGGEPASGRRSSSDRRSDGGKPATAPDPEEDEIMEDVDHEAPSETGANATFERGAEHAGTTESDAVADEATDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V7</accession>
    <name>R4W2V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445076.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01145"/>
    <dbReference type="EnsemblBacteria" id="AGN00182">
        <property type="protein sequence ID" value="AGN00182"/>
        <property type="gene ID" value="L593_01145"/>
    </dbReference>
    <dbReference type="GeneID" id="16180593"/>
    <dbReference type="KEGG" id="sali:L593_01145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.233"/>
    <dbReference type="eggNOG" id="arCOG03656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="429"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="579" mass="61353" checksum="FBAC4D68F2531014" modified="2013-07-24" version="1">MSGTRTGGELFVDALERYGVTHVFGNPGTTELPVVDAIERSDLEYVLAAHEDIATGMAAGYASTRRYHADAAGSRGGQAGDRAEPAENREVLPLGVANLHLAPGLAHGLGNIYGASVAGAPLLVTAGNHARHFEHEEPLLTGDQEALVDQWTKWSATVQDVAALPTMLRRAVRTALSPPTGPVFLSLPVDVAMAETDAAVDRLGPIPTAGRGDVAQVERTADLLADAEDVVLVVGDGVARAGTDAVDAAVDLAEAAGARVHAEILACEIDFPTDHEQFVSYVPPDEDLARSLLSADVLCLVGCSTNTTLTHREGPLVPEDTTCIHVGDDAWELGKNQPADAAVIGDPGEVAAQLADRLSERLDDATREQRLADVAAQKEFVGAKMDQMGEDEPPDDPRASKATLVDALEDVAGDAFVVDEGVTSKYAMLTRWEFEPEQYVSNKGGGLGYGLPAAVGAAIAERQRDEPRDVLGFVADGSYLYYPHSIYSAVRQDLDLTVVVPDNRNYRILADNAAHLLGGEGDDYEWDSIRFDPPVDIQKNAESHGATGHLVETPEELDETLAAAFGSEGVDVVDVLVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W300</accession>
    <name>R4W300_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445121.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01370"/>
    <dbReference type="EnsemblBacteria" id="AGN00227">
        <property type="protein sequence ID" value="AGN00227"/>
        <property type="gene ID" value="L593_01370"/>
    </dbReference>
    <dbReference type="GeneID" id="16182683"/>
    <dbReference type="KEGG" id="sali:L593_01370"/>
    <dbReference type="eggNOG" id="arCOG11494">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091393_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="11896" checksum="FFE7D05C50347131" modified="2013-07-24" version="1">MSVVAEFTTELDRIRAERRARWTATAIALGIGILAAFLDPLGIVLGAMLVALPAIDPYRGLLRGLGFGVLVVGLLAIQLFVAGTLGPAIGLGLPFYLAIGIGVGFGLLGGLVRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W310</accession>
    <name>R4W310_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445136.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01445"/>
    <dbReference type="EnsemblBacteria" id="AGN00242">
        <property type="protein sequence ID" value="AGN00242"/>
        <property type="gene ID" value="L593_01445"/>
    </dbReference>
    <dbReference type="GeneID" id="16182595"/>
    <dbReference type="KEGG" id="sali:L593_01445"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187753_0_0_2"/>
    <dbReference type="OrthoDB" id="96858at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="214" mass="23158" checksum="029E362C08142B66" modified="2013-07-24" version="1">MRSEQAGGTQDGSAFSEALATLKRNGSNVVVVGAEDRTAHERVCQRLLGTDAPRTRLVVRTTPGGTCGWLPPTDADGETHLITYGDPGEERDATIVDSDLLGPLGQAVADKIDAVTAGEGPEPAEFRVCLDALGPLFAEHDPETVFRLVHVVTARVRDVNGMGHFHLRLAPDDDHIKLLEPLFDAVVEVRTTGAGAQHRWRLLDKNVDSQWIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W315</accession>
    <name>R4W315_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative C2H2 zinc finger DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01495"/>
    <dbReference type="EnsemblBacteria" id="AGN00252">
        <property type="protein sequence ID" value="AGN00252"/>
        <property type="gene ID" value="L593_01495"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01495"/>
    <dbReference type="eggNOG" id="arCOG06236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3210688_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="44" mass="5189" checksum="8800B7F93795078E" modified="2013-07-24" version="1">MVVQTERDDMTWYECEKCGLLFDDRSDAKQHEGNCDSEDPSYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3J7</accession>
    <name>R4W3J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445466.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03105"/>
    <dbReference type="EnsemblBacteria" id="AGN00572">
        <property type="protein sequence ID" value="AGN00572"/>
        <property type="gene ID" value="L593_03105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180435"/>
    <dbReference type="KEGG" id="sali:L593_03105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.628"/>
    <dbReference type="eggNOG" id="arCOG00553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_1_2"/>
    <dbReference type="OrthoDB" id="9752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="234"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="778" mass="84562" checksum="4CFC5A15A304C339" modified="2013-07-24" version="1">MEVAEVLPSFADAFAFDEFNAMQRAAIPGILESDENVVASAPTASGKTAIAELAICKTLDRSGTALFVAPMRALTNEKEAEWDRFEELGYSVYVVTGERDLNPRRARRADILVMTPEKLDSATRKHDTHRYDFVTDVDTVVVDEVHLLDSERRGSALEVTISRLRRLCDPRIVALSATMPNVEEVAAWLDAPDATTFDFDDDHRPVELNADVKTYSHGENSFADKYRRLYRALDLAQPHLEEDGQALVFVASRQDTQRAAAKTRDELAERDIRIGARGDYDFHTETERLENDELRQGVLDGVAFHHAGLSKNDRDLIEEWFKQGKIELLFSTSTLAWGVNLPARCVIIRDTKYHDPLEGEVEMSPLDVLQMLGRAGRPGYDDVGYGWVITDRADADRYRRLLREGTEIDSNLADDLPEHCLAECCVGTIESRDDAIAWLQTTFYAVRAAGDDDEQLEARVDDTLASLAGDGFLDLDGPGGTDGVAPTALGRLASRFYLRLDTARGFHDLATREQIDDAGILRAVATAVEFDDVAARSDEADAVDAVLGERATDLPDGQRKVLAILQAAVAGTTPNSLRSDAWIIRQNALRMLAALGAVLGEFAGPAAANECRRLEARIEHGVGPDAAALTAIEGVGEGRARSLAQAGFESPAEIAAATPATVAAAGVGDGVAERIVDAAADLPRIEIEWGDLPDSIPAGDRDFSEATIHNRGDGAQAGVRVTVNGVEMTADETYLSDATTVPLALFGADADELELAVEVVFPELPLQPIEDRRTVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3K2</accession>
    <name>R4W3K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445476.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03155"/>
    <dbReference type="EnsemblBacteria" id="AGN00582">
        <property type="protein sequence ID" value="AGN00582"/>
        <property type="gene ID" value="L593_03155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180439"/>
    <dbReference type="KEGG" id="sali:L593_03155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.638"/>
    <dbReference type="eggNOG" id="arCOG04668">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088211_0_0_2"/>
    <dbReference type="OrthoDB" id="49516at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="28128" checksum="92778C5C0AEA1B24" modified="2013-07-24" version="1">MVDRVSLYAAPTTVAEVEPIAEWLDSRIDADVAVRDRFLDVHRTEDLPERFAEARVADPHDPATGNTMLGIVRYEERALEDPEREGGVLYDGTQVQSALNAAVPAAESGLEHAHVALLDRAIGTWGDHDGRWHKRVAVLGQPAIVSVPGLYEAPAKPEAYYKEKQRHALLSGDSPPREVLENQVEGDFLIEDDPRTTEALCGYVLAAFHLLDTGEAFCDAEGCRLFDAHYQADLVDAQLREPEFCDAHAERYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3M2</accession>
    <name>R4W3M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="233"/>
        </location>
    </feature>
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        <location>
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            <end position="265"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="207"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="39701" checksum="9D9405C18DCA7BDE" modified="2013-07-24" version="1">MTVRRDRTLLAVVVAAVLFAQVLLYPGIGDLVTALGATTELDAGMWFLAAEFGAFVVCVPVWGAVSDATGKRVPWIVLGAAGAAIGYATLAVLPAAIDLTFTGVLLLRVVQGAATIGAFSLAITMLMDLEGGHGKNMGAAGIAIGVGTALGAPVGGQLSELDPIAPLGFAALLLAAVALLVTLVEDRAPASDRSPREALAVVRRTPPLVVPYAFGLIDRFTAGFFALVGTLYFQDAFGLGPGDTGLVLMAFFAPFALLQYPMGALSDRIGRTIPVVAGSLCYGVGVIAVGVAPSIALAAAGMVLVGVLGALVAPATMALVTDLADPTDRGGAMAGFNLFGSVGFLGGFLLGGTVADASGYEAAFLVAGSLEIAIALIAAPAFLRLSLGRPTAASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3P8</accession>
    <name>R4W3P8_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="sali:L593_03555"/>
    <dbReference type="eggNOG" id="arCOG02795">
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    <dbReference type="OrthoDB" id="90861at2157"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="224" mass="24873" checksum="395638D2FF807520" modified="2013-07-24" version="1">MSEDDALAEPGPACEGGEDVDEAVANARNDVIAAMEQAATMYGLPRSAGRIYGLLYFAEEPLSLDVLAERSGYAKSTVSDVTNSLEEIYFARRVSGAGGGRKSYFEAERDIWYAMRQAMQDAGRREVELMRRTLSESERELEAALDAAERAADPERAATIADNLERVRDLQSLYRQFAVSLELFEQFPVERMLGILARFADDVDHEAFPESDDPSGDDHEETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W491</accession>
    <name>R4W491_9EURY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25485" checksum="F555A4D3DE669EBB" modified="2013-07-24" version="1">MSTAADARTAALRDRLATLSWYQRSVLLGGAVTIAWMNVPLQGIDARLLRDGLLFLAIPMAFALAHGNRLGWRVDRRAVKDALLLSAFVLPFYVVGSTLPGVREFYPMWGLDSAAPVPFLTHAIKQLFLVIAGETFFRGLLCVGLREKGPWVAFVSPVIYALLHASKPPVELLLSGPTDVLFGLTDYHANSLLPSVVAHGFGLILLDWLVLHDPLLDPETTAGWFEWLPFVV</sequence>
</entry>
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    <accession>R4W4A0</accession>
    <name>R4W4A0_9EURY</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">L593_05265</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445896.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05265"/>
    <dbReference type="EnsemblBacteria" id="AGN01002">
        <property type="protein sequence ID" value="AGN01002"/>
        <property type="gene ID" value="L593_05265"/>
    </dbReference>
    <dbReference type="GeneID" id="16181658"/>
    <dbReference type="KEGG" id="sali:L593_05265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1075"/>
    <dbReference type="eggNOG" id="arCOG00840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387553_0_0_2"/>
    <dbReference type="OrthoDB" id="76377at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="23493" checksum="4B3E8EAA861D8ECA" modified="2013-07-24" version="1">MYVRDAKNREEVWLLDHIEEFGLDDAAFRSRDYVVAIDESGGGKAGFGRIRIHKTEGGERSGGSRSSSDRRSDGGEFCELTSVGVLPEWRGQGVGAHVMERLIEHARDEGFETVFLFTPAAEYATQFGFEPVESSSLPDPMADRMDTVVAEEGEDTVALVVDVDEFVVPDRLRRRFKDAAPRGDDGDGDSEPEETAEDFGIDPDEATYKYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Q3</accession>
    <name>R4W4Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446161.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06600"/>
    <dbReference type="EnsemblBacteria" id="AGN01267">
        <property type="protein sequence ID" value="AGN01267"/>
        <property type="gene ID" value="L593_06600"/>
    </dbReference>
    <dbReference type="GeneID" id="16182349"/>
    <dbReference type="KEGG" id="sali:L593_06600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1347"/>
    <dbReference type="eggNOG" id="arCOG02702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_16_1_2"/>
    <dbReference type="OrthoDB" id="67424at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="20185" checksum="F9382DA742FA4664" modified="2013-07-24" version="1">MGYHTFDASRADKLERAERRFRFCSAEELRWALGADADATVADLGSGTGFFTDVVAPHVETCHAVDVQAAMHEYYREKGVPENVELVTSGVADLPFEDDALDGAFSTMTYHEFASDEALTELGRVLTESGRLAILDWSARGSGEAGPPVEERFSAAETTAALEDHGFAVEHAAERPETFLLVAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5I6</accession>
    <name>R4W5I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446636.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08985"/>
    <dbReference type="EnsemblBacteria" id="AGN01742">
        <property type="protein sequence ID" value="AGN01742"/>
        <property type="gene ID" value="L593_08985"/>
    </dbReference>
    <dbReference type="GeneID" id="16182592"/>
    <dbReference type="KEGG" id="sali:L593_08985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1843"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="25929" checksum="C5451008EF6CE360" modified="2013-07-24" version="1">MAGITVQADLELDAPTLVEGLPGVGLVGKIATDHLVETLGMTRYASITCEGLPKLGVYAAGERDVRPPVRLYADEASNLVALQSDVPVSPQAAPTFADCVTGWLETDDVTPIYCSGYASEDRSTPPGLFGVATGGAGDRLDDLEIGTPDEHGAISGPTGALVAAASERDVPGYGLVVESNPQFPDPEAARVLIREGIAPLTDVEVDTEALVEQAEDVQERREELAKKLQEAQQEASSEAKPLRMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U4</accession>
    <name>R4W5U4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="16" type="ORF">L593_00215</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444892.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00215"/>
    <dbReference type="EnsemblBacteria" id="AGM99997">
        <property type="protein sequence ID" value="AGM99997"/>
        <property type="gene ID" value="L593_00215"/>
    </dbReference>
    <dbReference type="GeneID" id="16180094"/>
    <dbReference type="KEGG" id="sali:L593_00215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.43"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OrthoDB" id="41214at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="15">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="14">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AGM99997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="35942" checksum="C339337560C349F8" modified="2013-07-24" version="1">MGNAALRELAAIEDVPIDSLAGEVVAIDAHNWLYRYLTTVVRFTRDDAYTTPNGEEVANLIGICQGVPRFLENDVTPVFVFDGAVTDLKADEVEQRREARAVREEQLERAREEGDAMEVARLESQTQRLTDTIQSTSRELLERLDLPVVEAPAEGEAQCAHMAADGTVDAAGTEDYDALLFGSPVTYRDLTSSGDVERMELQATLDRHGITYEQLVDAGILCGTDFNDGVHGVGPKTAIDAIQEHGDLFGVLDARGEELPHADRIRNLFFDPPVTDDYDIDLTVTPDLDAAREFVVDGWGVASDEVDRGFERIRDATQQTGLDRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H1</accession>
    <name>R4W6H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447206.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11845"/>
    <dbReference type="EnsemblBacteria" id="AGN02312">
        <property type="protein sequence ID" value="AGN02312"/>
        <property type="gene ID" value="L593_11845"/>
    </dbReference>
    <dbReference type="GeneID" id="16181567"/>
    <dbReference type="KEGG" id="sali:L593_11845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2438"/>
    <dbReference type="eggNOG" id="arCOG04561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161196_1_1_2"/>
    <dbReference type="OrthoDB" id="129602at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7272" checksum="065D5E6D796DF36E" modified="2013-07-24" version="1">MVFKKITLIGTSPESFDAAADDALDRAEDTLDNIHWAEVDELGVEVASVADREYQAEVTVAFELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L1</accession>
    <name>R4W6L1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447286.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12255"/>
    <dbReference type="EnsemblBacteria" id="AGN02392">
        <property type="protein sequence ID" value="AGN02392"/>
        <property type="gene ID" value="L593_12255"/>
    </dbReference>
    <dbReference type="GeneID" id="16179822"/>
    <dbReference type="KEGG" id="sali:L593_12255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2520"/>
    <dbReference type="eggNOG" id="arCOG02900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024783_0_0_2"/>
    <dbReference type="OrthoDB" id="37318at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="294"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="697" mass="76419" checksum="FA068D00D7918FEA" modified="2013-07-24" version="1">MDTTHADIESGERHDIEVELVSRRSIETEHGTVNRLLVTDRTATQFSVLVAEDSEPLLDLKTGATHRIAGLLGADPLPALPESEQDCPDCGAVLRPGRPFDAVGPAVTRAASELGLEEAFGVVDANAIVRRVRANEDRIDDWQPMHTEERLDPPVYVCRGCHRQLTRADVRQAPGLESHPDDGQFGDSNHCEANHSHAAPETVGLATGGAKDVTNFRENIANGYTPKPGAITDEGLFYDYHFETGERSSTDALFAPRYAAARSDHPITGETETFLSVGLDSTLSVDEFERPRLDLIAVLDVSGSMNSPFDEYYYDQQGRQRETQADDVTKLDAATQSLCALTTQLRPSDRLGIVLFNQQAHVAKPLRDVDSTDMPAIRRHIRNVSAGGGTNLADGFEAARSMFGSRNGPNVEQRVVFMTDMMPNTGTTDEKTLQRRFADAAVEGIHTTFVGMGLDENADLVKTLSGIRGANHYFVHSAAEFERRLGEEFDYMVTPLVYDLSLELDGDGCEVAAVHRSPSAEATTGQLIDVGTLFPSAKTDGEARGGIVLVRLDQMDPDADVELVATWSERDGGTHTERRSVELPSDSVSFGHDGVRKAVALTRYASALRSWARDVHEGEPPEAGVDDWQLEKFLGRHEEMSVPLVVPGEHADRFQQLREYLEQEMVAVGDEDLQREIDLLETLATHPVRINGEVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W712</accession>
    <name>R4W712_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447526.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13465"/>
    <dbReference type="EnsemblBacteria" id="AGN02632">
        <property type="protein sequence ID" value="AGN02632"/>
        <property type="gene ID" value="L593_13465"/>
    </dbReference>
    <dbReference type="GeneID" id="16180662"/>
    <dbReference type="KEGG" id="sali:L593_13465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2754"/>
    <dbReference type="eggNOG" id="arCOG04617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126924_0_0_2"/>
    <dbReference type="OrthoDB" id="92104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="183" mass="19877" checksum="5511DAA0F9B56422" modified="2013-07-24" version="1">MRIRDWDDLVKDVVESDVDPEGWRAVAGDRSSGLGEDMYLGHPGAGVYQLKTFAKNPFEVRGVGAQVARRIDEDLDPLFPGEDGGARFAVNDGPADEDEAETMASRVEEVVKTHADAPTTADALFEDVMDAMDAPAYGPMEYDQYGRPDALDDLAGTFDEAEELLDAELDDLVDDASVGRGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W723</accession>
    <name>R4W723_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447546.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13565"/>
    <dbReference type="EnsemblBacteria" id="AGN02652">
        <property type="protein sequence ID" value="AGN02652"/>
        <property type="gene ID" value="L593_13565"/>
    </dbReference>
    <dbReference type="GeneID" id="16180618"/>
    <dbReference type="KEGG" id="sali:L593_13565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2777"/>
    <dbReference type="eggNOG" id="arCOG00614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099718_0_0_2"/>
    <dbReference type="OrthoDB" id="118207at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="211" mass="22563" checksum="5F48538805287C04" modified="2013-07-24" version="1">MSSRYDRRQDATIRFSRRELRDLAAAWLALSIAFTIFIGRPPVLAAHPTWAARLFVVCIFSVGVAFMLHELAHKVTAIRFGQLAEFRADYSMLGVAIVGALAGFIFAAPGAVHHVGRITDRENGIIALAGPASNVALVGAFAPLLLFDGIVYSVGAFGVFVNAFLGAFNLIPFGPLDGRTVYRWHPGVFALAFGGSIALVAGVFLTIGFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W765</accession>
    <name>R4W765_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aspC</name>
        <name evidence="7" type="synonym">aspS</name>
        <name evidence="9" type="ORF">L593_04135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445672.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04135"/>
    <dbReference type="EnsemblBacteria" id="AGN00778">
        <property type="protein sequence ID" value="AGN00778"/>
        <property type="gene ID" value="L593_04135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180837"/>
    <dbReference type="KEGG" id="sali:L593_04135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.841"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OrthoDB" id="24288at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="134"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="434" mass="48627" checksum="41E07531073A9398" modified="2013-07-24" version="1">MDDRTYAAEAEPGQTATIAGWVHEVRDLGGIAFVIVRDATGRIQVKVEKGEIDEDLEELATEVTRESVVEVTGPVEEEERAPTGVEMTIDSFEVVAEAEPELPLDPSGKVDAELPTRLDNRTLDTRKPEVKAIFEIRSTVLEAVREEFRNLRCTEITTPKIVATGTEGGTELFPITYFGQEAFMNQSPQLFKQLAAGGGFERVFEIGPIFRAEEHNTPRHLNEATSIDFEGAFCDAGDAMDVAEAIVTAAYEAVSEQNQRELELLDLEEEFAPPEGDFPRLTYEEAIERVNATGALDEQLVWGDDLSTEAEKALGEDVGRHYFITNWPSEVKPFYIKDTDEDPQESTGFDLMHPVMELVSGGQREHRHEQLVEGFEQQGLDPAQFEYYTKMFKYGMPPHAGFGLGAERLVMTMLDLDNIRETVLFPRDRQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E7</accession>
    <name>R4W7E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14655"/>
    <dbReference type="EnsemblBacteria" id="AGN02867">
        <property type="protein sequence ID" value="AGN02867"/>
        <property type="gene ID" value="L593_14655"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2992"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="490" mass="54469" checksum="B3F16C18927244A2" modified="2013-07-24" version="1">MATAETERAPPKFAQTRWEPMTEPLLEVRDLEKYFFERDTYVDRIMGSDPVSIKAVDGISFDVHEGETLGLVGESGCGKSTTGETLLGLQEPTGGTVRFDGDDVFSLSRSGMRTFRRNAQVVFQDPFSSLDPRMTVGAIVRQPLEVHGVGTLAEQRERVHDLLERVGLSADQYDRYPHEFSGGQRQRIGIARALALEPEFLVLDEPTSALDVSVQAQILNLLSDLQDEFDLTYLLISHDLSVIRHICDRVAVMYLGELVEVGPVGEIFESPRHPYTQALLESVPRASTDERDRDVETLSGDVPSPRNPPSGCRFRTRCPDVIPPDALDVEQAEYRQIMDVRERIESEDVDLDSVWDYVADGPPSSFGSIRSYLDRSGDGTDDYRDQHVDAFVDRLETRLVDVDLSAPHDRTVREAFRELCYGDWDEAAAVLADDYESICETVTPVLQDGADHPVACHLYDQPPVEDGRSTGARPDVGSADSVDAENASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7N8</accession>
    <name>R4W7N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445972.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05645"/>
    <dbReference type="EnsemblBacteria" id="AGN01078">
        <property type="protein sequence ID" value="AGN01078"/>
        <property type="gene ID" value="L593_05645"/>
    </dbReference>
    <dbReference type="GeneID" id="16182083"/>
    <dbReference type="KEGG" id="sali:L593_05645"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1156"/>
    <dbReference type="eggNOG" id="arCOG04782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056466_1_0_2"/>
    <dbReference type="OrthoDB" id="68275at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="27181" checksum="0DE0BD3A8863D00A" modified="2013-07-24" version="1">MGILSRASYVVRSKVNAAIGRAEDPAQTLDYSYEQLQDELQSVKRGIADLTTQKKRLETQRRRLEENVEKHEDQARRAVEQDRDDLARRALEKKRTKSAQIDQLDDRIEELGMTQDDLVEKKEALQERVDQFRTRKETLKARHQAAEASTRVSEAVTGAGDELADVNRAIERAEDQTREMEARSAALDELEEEGVLEDQLREESSLERELSELTETDEIDEELAEIKSSVEGEPVDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q7</accession>
    <name>R4W7Q7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="3 9">4.3.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">FO synthase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">cofG</name>
        <name evidence="11" type="ORF">L593_00095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The FO synthase complex consists of two subunits, CofG and CofH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="3 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444868.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00095"/>
    <dbReference type="EnsemblBacteria" id="AGM99973">
        <property type="protein sequence ID" value="AGM99973"/>
        <property type="gene ID" value="L593_00095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182798"/>
    <dbReference type="KEGG" id="sali:L593_00095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.19"/>
    <dbReference type="eggNOG" id="arCOG00657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054174_0_0_2"/>
    <dbReference type="OrthoDB" id="52096at2157"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGM99973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="390" mass="42290" checksum="F7BA447FD0A7E663" modified="2013-07-24" version="1">MIPGAAEYDVDVEISDAAVERLLAVEPDDVESAEALSFARNVFLPLTTACRYTCTYCTYFDPPGEATLMTPEDIRDVCERGADAGCTEALFTFGDDPDDRYDGIYEQLDELGHDSIHEYLREACEIALDAGLLPHANPGDQTREQMETVADVNASMGVMLETTADVAAHAGPRTKSPGQRLDTIRTAGELGVPFTTGILLGIGEDWEDRAESLLAIRDLHERYGHVQEIIVQPVRENERWSGDSPGLDMLRRATAMARAAMPPAVSIQVPPNLAPAGEVVDCGIDDLGGVSPVTDDHVNPDYAWPALDHLQTIADEAGVPLRERLPVYERFVPPQLRGGAAEDGSGATGVRAEDPWLSERIQRAIASDDDAGRRYRRVLANGPIADPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q8</accession>
    <name>R4W7Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446017.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05870"/>
    <dbReference type="EnsemblBacteria" id="AGN01123">
        <property type="protein sequence ID" value="AGN01123"/>
        <property type="gene ID" value="L593_05870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180553"/>
    <dbReference type="KEGG" id="sali:L593_05870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1202"/>
    <dbReference type="eggNOG" id="arCOG04512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641945_0_0_2"/>
    <dbReference type="OrthoDB" id="53108at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="436" mass="47910" checksum="BF897249E46BA740" modified="2013-07-24" version="1">MSPDPSRAIPRREFVRSAVAIGGASALAACLEAESNSDDPGEPQFPQGPEDLSMLPERQHAWNAYLRRSPSGNTNLPEQQLVLFYRYTGSVPPAEDERTAVEETLRSIERAYQRGTGGDTSATFSRGLLFMLGYSPSYFDRFDESLPEDVGLQRPEDVIDQLDEDATPEEADVAILLNSDFGSIPLAVEEALAGEVDRINGIDVGGDFSSVFEQIGRRPAVVGRGNPAEELDHPEIEEESPLSMGYKSGFDDSNPPEDAVTIEDGPFDQGTTQLVSRMGIDLDGWYDMSEEERVTQMFGTSYDTEDVGDTGENLGGHSRITPDDTENLEEKAAEHGRLGHSQKTARARDDSFQTKILRRSEGNVSDPEFDAGMNFTSVQRDLANFVEVREAMNDLGSDDIDAHHSGIVDFLTVVRRGTYLVPPRSKRALPSPRPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T6</accession>
    <name>R4W7T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01188">
        <property type="protein sequence ID" value="AGN01188"/>
        <property type="gene ID" value="L593_06195"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06195"/>
    <dbReference type="eggNOG" id="arCOG05278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3039219_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="6266" checksum="ED88296BF153A6DE" modified="2013-07-24" version="1">MATEFDCHQDAGFECDFHIVDENEDELVDFVQIHGRSAHDTTVEESDIREMLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W805</accession>
    <name>R4W805_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Acetyltransferase (Gnat) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445088.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01205"/>
    <dbReference type="EnsemblBacteria" id="AGN00194">
        <property type="protein sequence ID" value="AGN00194"/>
        <property type="gene ID" value="L593_01205"/>
    </dbReference>
    <dbReference type="GeneID" id="16182819"/>
    <dbReference type="KEGG" id="sali:L593_01205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.245"/>
    <dbReference type="eggNOG" id="arCOG00834">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102818_0_0_2"/>
    <dbReference type="OrthoDB" id="74004at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="19534" checksum="B5C649A63B1F27A9" modified="2013-07-24" version="1">MTGRIYPDEVAGPFPTPPREFEDAEGRLIELQAAGGMDPEPVVEMYTAFDPADRAQGIPPSQEDRIRSWLDTLLTEGLNVLAWDGPDVVGHAVLMPDTDGWELAIFVYQPYQGAGIGTQLIETLLGYGAAEGVERVWLTVERWNRPAIALYKSVGFEPCEAESFEMEMSLVITDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W836</accession>
    <name>R4W836_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445168.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01605"/>
    <dbReference type="EnsemblBacteria" id="AGN00274">
        <property type="protein sequence ID" value="AGN00274"/>
        <property type="gene ID" value="L593_01605"/>
    </dbReference>
    <dbReference type="GeneID" id="16179873"/>
    <dbReference type="KEGG" id="sali:L593_01605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.326"/>
    <dbReference type="eggNOG" id="arCOG02959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_0_0_2"/>
    <dbReference type="OrthoDB" id="14580at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="208"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="433" mass="47043" checksum="8EEE8F3B05A1A8E1" modified="2013-07-24" version="1">MTNWIGEAFTSDAGWNHLETLVDVGDRMAGSEGEREAAAATRDALAEVGARDAHLESFDVQGWTRGTSELRAGDTSQECIALPRSPSGEATGELIDVGYGLPSDFEQDLEGAVVMAASNVPGWYDRFLHRREKYYHAVEAGAAAFVFRNHVEGCLAPTGSVGTEDDPIGDVPAIGVSKEVGDRLLRRWEGDSVTVDVEAEISDATSRNVHATLGPDTDEEVLLTSHVDAHDIAEGAGDNGAGTAVVVEAAKALAAREDELDTKVHLLVYGAEEVGLCGSAYDSDQRDHDDIKAIVNSDGVVRGRTLRCYTHDFDELEAAAETVADRFDHPIETTPKLNPHSDHWPYVQWGVPGFHLMSETDYEGRGWGHTRADTLDKLEQRTLREQSILIADLVDHLADSDTTIEHRTPESIAAQLEDDDLAEGMKVIGDWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A6</accession>
    <name>R4W8A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02615"/>
    <dbReference type="EnsemblBacteria" id="AGN00474">
        <property type="protein sequence ID" value="AGN00474"/>
        <property type="gene ID" value="L593_02615"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02615"/>
    <dbReference type="eggNOG" id="arCOG02917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="14646" checksum="DEBE9702204968BA" modified="2013-07-24" version="1">MRTRRNVLGKFGTTGAVALGAGLAGCSGDDGGGGGGNTVEMTDSLTFEPGNLTVSTGTTVTWENGGTVAHTVTAYEDRIPSGATYFASGGYESETAARDGFRGGDAPIEADGSFEHTVDIAGSYEYFCIPHEGSGMTGTITVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G0</accession>
    <name>R4W8G0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="6 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L593_08940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 14"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446627.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08940"/>
    <dbReference type="EnsemblBacteria" id="AGN01733">
        <property type="protein sequence ID" value="AGN01733"/>
        <property type="gene ID" value="L593_08940"/>
    </dbReference>
    <dbReference type="GeneID" id="16182609"/>
    <dbReference type="KEGG" id="sali:L593_08940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1834"/>
    <dbReference type="eggNOG" id="arCOG01112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_2"/>
    <dbReference type="OrthoDB" id="40634at2157"/>
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        </location>
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        <location>
            <begin position="500"/>
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        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="594" mass="61862" checksum="682BE69A5B9EF4E5" modified="2013-07-24" version="1">MRNAKIVCTLGPASGSRETIRELAQAGMSVARLNASHGDRADRRAMIERVRSVDRELDRPVAVMLDLQGPEIRTAPLEEPIELETGSMVQFVEGETATPETVGLSIPIDGVEADDRMLLDDGRIEAVVSEVDEDGVLARIVSGGELGGRKGVNLPGVDLDLDVVTAKDRADLELAADPGVDFVAASFVRDRDDVLAVNEAAEDAGADVPIVAKIERAGAVDNLGGIVDAAYGVMVARGDLGVELPMEDVPIIQKRIIREARNAGVPVITATEMLDSMIHERRPTRAEASDVANAVLDGTDAVMLSGETAVGEHPVQVVEAMDRIVSQAERSGEYAELREQRVPSAGESRTGAIARSARFLARDLGASAVVAASESGYTALKTAKFRPPVPVVAATPNEAVRRQLALSAGVIPMSRSFVDGGADKVVETAVGAALDASVAESGDTVVVLSGMMTELEGAQTTNMLKVHVAAETVATGRSVVDGRVSGPVATAPDGDLGAVAEGSVLVLDSEFEAEFSGDPARLAGIVDARKGMTGYPAMVARELEIPMISGAPMAESVAPGDEVTLDAERGVVYAGAIDPGADREGRSLDSAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H4</accession>
    <name>R4W8H4_9EURY</name>
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        <name evidence="2" type="ORF">L593_09165</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="arCOG08189">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9504" checksum="75630A536B8B9281" modified="2013-07-24" version="1">MHTGDRSGATTPVGPRGSNWGRQYRLVSELRRPGERLSIPDRAENVSVDVLSTQMVRVTYLSPLYEVSFEDDAEEDSGADPRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I4</accession>
    <name>R4W8I4_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Ba3-type terminal oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_03590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00669.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00669">
        <property type="protein sequence ID" value="AGN00669"/>
        <property type="gene ID" value="L593_03590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180610"/>
    <dbReference type="KEGG" id="sali:L593_03590"/>
    <dbReference type="eggNOG" id="arCOG01236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120355_0_0_2"/>
    <dbReference type="OrthoDB" id="77144at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ba3_CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034214">
        <property type="entry name" value="Ba3_CcO_II_C"/>
    </dbReference>
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        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
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        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0186">Copper</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="4">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="172" mass="18471" checksum="A385765FB36311E2" modified="2013-07-24" version="1">MEIHRFEKLWLVAALLLIVAFIGTIVYGALGAGVAMVDDSGGTVDPDDPTASDNFREPGVYTTEDGDVEVYVIARQFLFSPGSTEPIQVPADTEVTFYVTSGDVTHGFYLPGTNVNTMIIPGQVAEITVEFDETGDHHIVCHEYCGASHHTMRGTVEVVSQSNFDGNGVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K8</accession>
    <name>R4W8K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_09765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446792.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09765"/>
    <dbReference type="EnsemblBacteria" id="AGN01898">
        <property type="protein sequence ID" value="AGN01898"/>
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    <dbReference type="KEGG" id="sali:L593_09765"/>
    <dbReference type="eggNOG" id="arCOG01768">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
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        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF144091"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="43"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21085" checksum="9474915D410980D7" modified="2013-07-24" version="1">MVRATPQIIAICLVVYVAQLGVALAVGAEQMAELFALALPLDAQPWTVVTSVYAHSGPWHLLSNLALFALLGLAVERKASATGVHLYVLATGAIANVSQVVFSNVVVSVDAHVLGLSGAIFALIGYVVTGNRLSGFMLDRFEVPHGVQLVVYLALAVAVTLATAEPGVAIVGHFTGLFLGLVLGAGTVLSADRLAVEEPPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S8</accession>
    <name>R4W8S8_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445788.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00894">
        <property type="protein sequence ID" value="AGN00894"/>
        <property type="gene ID" value="L593_04725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181051"/>
    <dbReference type="KEGG" id="sali:L593_04725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.966"/>
    <dbReference type="eggNOG" id="arCOG12322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077613_0_0_2"/>
    <dbReference type="OrthoDB" id="41772at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="312" mass="35082" checksum="E5B5A4038552C941" modified="2013-07-24" version="1">MAAPEQIEWLLAGDPAIRWQVLRDLLDAPAEEVAAERARVVDIGWGSRLLSLQGEDGRWAADRGPKGYRGIYSPKWTSTTYTLLLLRRLGVPPGNDGALAGCDALVRHADWTDAAGVRLWNADTSDTCVSALVCSVLEYFDAEATRERERLLEYLLAEQTDDGSWSADKGPMHATIAALEALAIRRERVPSGYVDAAIERGREYLLERQFFRSPETGEVLDPAFRRLSFPPRWHYDVLRGLDHFQATDAPADDRAAAAIALLERKVDEDGRWPLEDHHSGEEHFVVEEPGEPSRWNTLRALRVLEWWREASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T4</accession>
    <name>R4W8T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04800"/>
    <dbReference type="EnsemblBacteria" id="AGN00909">
        <property type="protein sequence ID" value="AGN00909"/>
        <property type="gene ID" value="L593_04800"/>
    </dbReference>
    <dbReference type="GeneID" id="16181095"/>
    <dbReference type="KEGG" id="sali:L593_04800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.981"/>
    <dbReference type="eggNOG" id="arCOG02244">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127125_1_0_2"/>
    <dbReference type="OrthoDB" id="100903at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="14512" checksum="DD4EE95118AB4AFA" modified="2013-07-24" version="1">MSQSYDRGLIEDFGRWREFSAGMWAWILHKFTGWILIGYLFTHIAVLSTAIQAAGGDPAAYTDTLQGLESVLVIRILEIGLLATAVFHILNGVRLLMVDLGIGLEAQDKSFYAALVVTGAVVVASVPTFLGGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U8</accession>
    <name>R4W8U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10790"/>
    <dbReference type="EnsemblBacteria" id="AGN02103">
        <property type="protein sequence ID" value="AGN02103"/>
        <property type="gene ID" value="L593_10790"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10790"/>
    <dbReference type="eggNOG" id="arCOG02331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06315">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="657" mass="71738" checksum="6F98A5F2A8ECF164" modified="2013-07-24" version="1">MAADGAAARSIQAVLEASLSGYRIANADSIAAATDGLDEAVSCVVTPGTLPDGSGVDLAARIADRERSPPVVLVPREIDETVALATTDGVAAIVPAEHEDRLAAAVDDVASSYLERFGKELQLEAVETMFGAIEDVFQIKDADGRYLRLLSNREWPSESDALGRTDRVLHDDQFGVNETYYAEDQQVLDSGDPILGEVTAYGDGPLFWLETTKVPLRDDDGTVRGLVGHVRDVSDRMQDRSELERKNQRLDRFAGYVTHDLQNPLSIATGYLELAKEGDEEALAAVEDAIERMQQLIDDIEILARGEQRMLQTGDDGTLVAAQQHVVEIVRNVWSVLAPETATLEIDLPEGTVLYAGEQEFRSMLENLLKNALQHGGEDVTVRIGRVYGGMYVEDDGPGVPVDERDEIFEQGYSTAKGGTGTGLAIVDEVATAHEWDLEVETGTDGGARFVIGNCLLITDRDHIAAPSESIELTERADVGEPGTPGRSHFDPDDETWTIESAGEDIWGWENDFHFVHATCSGDVRIEARLRDALDRNEFSKTGIMVRDDLAEDSALGYVGLTRDTLEVLWCSEAGERTRSQQIGDTEGRYDWLRLDREGDLLTAFVSADGAEWFPIDQRRVALGETVHAGLAVCSAVHRDSCTATFSDVTVHRLTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W8</accession>
    <name>R4W8W8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps13p</name>
        <name evidence="4" type="synonym">rps13</name>
        <name evidence="7" type="ORF">L593_05250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445893.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05250"/>
    <dbReference type="EnsemblBacteria" id="AGN00999">
        <property type="protein sequence ID" value="AGN00999"/>
        <property type="gene ID" value="L593_05250"/>
    </dbReference>
    <dbReference type="GeneID" id="16179826"/>
    <dbReference type="KEGG" id="sali:L593_05250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1072"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OrthoDB" id="84219at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="19922" checksum="2130480E2324367C" modified="2013-07-24" version="1">MSAEDTPDDEDEDLRYFVRIGQTDLDGTKSVERSLTEMNGIGRRTARIIAEEAGVDRRATFGALDDDVIESVVELVESIEDEIPEWMVNRPSDYYTGEATHETGNDLSMTRQHDINRMKKIDSYKGVRHRGGHKVRGQRTKSTGRTEGTIGVNVEEIKEDMAAEAAEEAEEEDDEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X7</accession>
    <name>R4W8X7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_05375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445918.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05375"/>
    <dbReference type="EnsemblBacteria" id="AGN01024">
        <property type="protein sequence ID" value="AGN01024"/>
        <property type="gene ID" value="L593_05375"/>
    </dbReference>
    <dbReference type="GeneID" id="16180679"/>
    <dbReference type="KEGG" id="sali:L593_05375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1098"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_3_1_2"/>
    <dbReference type="OrthoDB" id="22814at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="10">
        <location>
            <begin position="386"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="458" mass="49901" checksum="B3AAEA2EC55B781E" modified="2013-07-24" version="1">MTSERFGYLTPQTLGLFTDRYELTMMRGYGENDHTPEATFSLYYRSLPTNRGYVIAAGLEQVLAYLDSIEFGERALPHLRAEGFPEGFLDVLADFEFTGDVRAVPEGTAVFPNEPLLEVTAPIEQAQLFETLVLNQVGFQSLIATKAARMRDTVDRHDEDVTLVDFGSRRAHGTDAGVKAARAAFVGGFDGTSNEAAAEAFDLPAYGTMAHSWVQSFETERAAFEAFVDVYGEDAVLLIDTYDTVAGAETALDVARERDVDVRGVRLDSGDLPALSVAVREILPAEMDVFVSSGVDEFFLREFYERDGVADGFGPGTSLTTSKDAPTLNPVYKLVAVEQDGEMTPSTKLSAGKVSYPCAKSVHRFEDEDGLARDVVARRDEDVGGRELLVDVVQDGEVVYDSPDLAAIRDRTARTLAKVPAGVRAIEDPEEYPVAISDGLAATTDRLEADLRKEAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W901</accession>
    <name>R4W901_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTP synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445988.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05725"/>
    <dbReference type="EnsemblBacteria" id="AGN01094">
        <property type="protein sequence ID" value="AGN01094"/>
        <property type="gene ID" value="L593_05725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181479"/>
    <dbReference type="KEGG" id="sali:L593_05725"/>
    <dbReference type="eggNOG" id="arCOG04783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170794_0_0_2"/>
    <dbReference type="OrthoDB" id="106416at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="11140" checksum="E3A204EA7891DE1E" modified="2013-07-24" version="1">MTTAVLVGPDADGLGDALEDVGVTVTRVGDVATRPDLEEAGILDADLLVVTDVEEATTIPIATDLNPDVRAVVYDRAALPEFVSAQTDLAVDPELLGPADVAEALVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W909</accession>
    <name>R4W909_9EURY</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_05800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05800"/>
    <dbReference type="EnsemblBacteria" id="AGN01109">
        <property type="protein sequence ID" value="AGN01109"/>
        <property type="gene ID" value="L593_05800"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1187"/>
    <dbReference type="eggNOG" id="arCOG06273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011657_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0701">S-layer</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="668"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="751" mass="77076" checksum="0EC0DD9B632C17C1" modified="2013-07-24" version="1">MVLSVVAASAALTGGVAASHAGSSYDVEVQENQNPRVWDGQTIRFNFTTDDTYTVTGPDGSDLGDFDTDASGNHTLDSSTLPATGEYTVEDSSGSTVTNFTLTTQTLSASFGDSSINSGQNTTVTLDTNRAENFTVVASSDGADVSTVFGDQNITEVKGGLGTSTTVNATTAGLAAGTYNFTFEAHDSDASATATITVEEGTDEDATFDSQSYSTVVGDTTSFDLETMGQPDEVWLNISDDEGYYTATVLLNNTNYDDDNTLSLTWNTHNASQNGSTLGLTETNGDATVNVVNAEGAAIMADNLLNRSSTYTFESFVDDPMGSGEFRDVSSVRVNERSNGPVTVWTAPSSTNYGTLNASELVGASTQDNTIANDDLLVLQVETNGVYGYMADDLANFNTTGGLNLTLTETNTGPYSDGATVNIQDISGNSTLIKQPGEGQFLVAIDTAQVGSISAGSSWDAAFSIHESNPYVDSTISSTASLSVEERSLEITGDFSDGTLQLPNSDSAEVTAESNVAPGTAVNVRMNFPFQFVTTSGEIADDGTFSSAVNLSQFEAGTQFDTRVSLGTGLSKTVGSVITESGDGPTNATASFSVSANAPSEVEQGAQAQLGYSFTNDGDADGTVEYTVTVNGEEVDSGTANLSAGSSTSPMVYEFDTSSAGDVEWSVSTQHDSASGTLTVAESGGDDTGGDDTGGDDTGGDDTGGDTGGDDTGGDGDGDSDGDGGGQPGFGLVVALFALIGAALLALRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W923</accession>
    <name>R4W923_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447182.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11725"/>
    <dbReference type="EnsemblBacteria" id="AGN02288">
        <property type="protein sequence ID" value="AGN02288"/>
        <property type="gene ID" value="L593_11725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181078"/>
    <dbReference type="KEGG" id="sali:L593_11725"/>
    <dbReference type="eggNOG" id="arCOG04561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161196_3_0_2"/>
    <dbReference type="OrthoDB" id="126140at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7711" checksum="C13508B8820255C2" modified="2013-07-24" version="1">MTTVKIIKLLGTSEESWDDAAREAVATASETIEDVHGVEVEDRTATVEDGEITEFKTTLEVAFPVHHQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W937</accession>
    <name>R4W937_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447227.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11950"/>
    <dbReference type="EnsemblBacteria" id="AGN02333">
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        <property type="gene ID" value="L593_11950"/>
    </dbReference>
    <dbReference type="GeneID" id="16180669"/>
    <dbReference type="KEGG" id="sali:L593_11950"/>
    <dbReference type="eggNOG" id="arCOG03067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_5_0_2"/>
    <dbReference type="OrthoDB" id="105261at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="111" mass="12771" checksum="E166442FD6778E7B" modified="2013-07-24" version="1">MDPVELLSTLGNKYNPEILQTTYEPKSAQELSEELDIPIATSYRRVEQLQELGLLEQEGKEFSDEGRQRKVYRRNVDEIVVELGNDDLDVDTTERTEAKNALNDVWSDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W955</accession>
    <name>R4W955_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447287.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12260"/>
    <dbReference type="EnsemblBacteria" id="AGN02393">
        <property type="protein sequence ID" value="AGN02393"/>
        <property type="gene ID" value="L593_12260"/>
    </dbReference>
    <dbReference type="GeneID" id="16180524"/>
    <dbReference type="KEGG" id="sali:L593_12260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2522"/>
    <dbReference type="eggNOG" id="arCOG03167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524415_0_0_2"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="520" mass="58491" checksum="3D02FF02B0751C6F" modified="2013-07-24" version="1">MAVDPADSLVRALDEHNPWWERGADAFSLPARQRSDFYHLARPDDEGSQFEDQPILGLTGRRGAGKTTLLKQFVQHRIQQGDAPEQFCYLPFDADPLFQLQSDEQLRRAVRYYENRVLSAVDEERPHFLLLDDVHLIEHPNKTTIEGWGTPVAKLIEDAPRRHVAVTASAGVQVDRELDRVGIDESEYGVQPILPEKFRDYVFSLYPDLEEGDTRVSPTSLREGEHSLPEVLRTGDVEPFVAELRRKYEQVEGEERRIQSQLVDYLAMGGIVSYAQDGVVESASDLESADYAMLRENVRDALYQEVPGFESIQTIGDLERLCALAARNRGGESLKYQDLVDLFDVDRRTIVDSYLPALETLYLLTGVNEYDNARPRSVRLFLRDPGLVVALTGGSAGSVLADFDLETDLARVTAFDHTMRFAYGIEAIQGRDEAPSVQYWEGREGEVDFVFEVDGTPVPVGLAYRSGDREVTRSAIGEFRSEYEAPIGILLTGDTAGRASIEDVQQGIVTLPYWFYLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D8</accession>
    <name>R4W9D8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein component 4</fullName>
            <shortName evidence="3">RNase P component 4</shortName>
            <ecNumber evidence="3">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rnp4</name>
        <name evidence="4" type="ORF">L593_13220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447477.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13220"/>
    <dbReference type="EnsemblBacteria" id="AGN02583">
        <property type="protein sequence ID" value="AGN02583"/>
        <property type="gene ID" value="L593_13220"/>
    </dbReference>
    <dbReference type="GeneID" id="16182665"/>
    <dbReference type="KEGG" id="sali:L593_13220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2705"/>
    <dbReference type="eggNOG" id="arCOG04345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079140_3_0_2"/>
    <dbReference type="OrthoDB" id="128960at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10484" checksum="7D874218200AA45D" modified="2013-07-24" version="1">MSNAIAVERIQRLAALAADATADGDVERGRSYVRTARQLAQRQRLTLPKEFRRRTCDRCDAYLIPGTNARVRTQDGHVVVTCDCGEIARYPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E1</accession>
    <name>R4W9E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446318.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07395"/>
    <dbReference type="EnsemblBacteria" id="AGN01424">
        <property type="protein sequence ID" value="AGN01424"/>
        <property type="gene ID" value="L593_07395"/>
    </dbReference>
    <dbReference type="GeneID" id="16182113"/>
    <dbReference type="KEGG" id="sali:L593_07395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1511"/>
    <dbReference type="eggNOG" id="arCOG06322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_2"/>
    <dbReference type="OrthoDB" id="56193at2157"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="31010" checksum="7093A497F872DCC1" modified="2013-07-24" version="1">MIPPIASRFVGGETPAEAVDTAWDLQDRQVGAILNLLGEHYTDPEDAAGDRDAYRDLLADIEDPELRACVSVKPSQLGLDVGADTFRENARLVVEAAAEHDGFVWFDMEDHETTDVTLDAVEAFATDGHDVGVCMQANLRRTEADVERFADVPAKVRLVKGAYDEPEAIAYTDRAAVNDAYRDLLTQAFETYDGGVAVGSHDEQMIEHAIECHEATGTDFEFQFLAGVREDRLFDLAETYECWQYVPYGGKWFSYFSRRVLERKENALFALRAILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F6</accession>
    <name>R4W9F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447517.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13420"/>
    <dbReference type="EnsemblBacteria" id="AGN02623">
        <property type="protein sequence ID" value="AGN02623"/>
        <property type="gene ID" value="L593_13420"/>
    </dbReference>
    <dbReference type="GeneID" id="16180604"/>
    <dbReference type="KEGG" id="sali:L593_13420"/>
    <dbReference type="eggNOG" id="arCOG06330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170810_0_0_2"/>
    <dbReference type="OrthoDB" id="125511at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="11980" checksum="5AA9E268C8563C1A" modified="2013-07-24" version="1">MSLDGRHRAVVDEIDDWSAVLLIENERGDEVIDEVRVDNDDLPTGVEEGAVLTASFEAGDLLHLVFEPAETERRRSEMADRFDRLAERPPGSEGNGDGGDTDEPSDTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I1</accession>
    <name>R4W9I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447572.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13695"/>
    <dbReference type="EnsemblBacteria" id="AGN02678">
        <property type="protein sequence ID" value="AGN02678"/>
        <property type="gene ID" value="L593_13695"/>
    </dbReference>
    <dbReference type="GeneID" id="16180816"/>
    <dbReference type="KEGG" id="sali:L593_13695"/>
    <dbReference type="HOGENOM" id="CLU_1060148_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="262" mass="28690" checksum="C9FE858DC37EC81B" modified="2013-07-24" version="1">MNVWKFAIVFVTVLGVLLGLPLVWWLGGLPGLRWIVVVALISTAAFLVAAPFAALGAAKQALEEFQSRPLLVELNPLWGSLDFAIHRLDRETIADTEMTWGDFEEPSGTKVPVFISLSWEKETNRAVGPWWASASPRELVGLKYKVHETYDRLEREAANAMHTEATMRSGMRRGVQRHQAGVMDAYDSETLPEGEEFGDVFANIEEQYRKDPDADPTDAAGGHARPDTPDPDQDAAEDDAGALPPGETPEEPPAAPDGGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P0</accession>
    <name>R4W9P0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="11" type="ORF">L593_08620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446563.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08620"/>
    <dbReference type="EnsemblBacteria" id="AGN01669">
        <property type="protein sequence ID" value="AGN01669"/>
        <property type="gene ID" value="L593_08620"/>
    </dbReference>
    <dbReference type="GeneID" id="16182480"/>
    <dbReference type="KEGG" id="sali:L593_08620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1766"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_3_1_2"/>
    <dbReference type="OrthoDB" id="33997at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="446"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="568" mass="63073" checksum="401AFF9E789B0B80" modified="2013-07-24" version="1">MHRESPDSDAQRDDRSDAAAPAWWRGTADAEGDESPRVLTDGGTAEGADETTLDPWGSATVSDYRKLFEQFGIEEFDEILDEVPNPHYLMRRGVIFGHRDYRAVADAMRNDEPFAALSGFMPTGEPHIGHKLVFDEIIWHQEQGGDAYGLIADLEAHSAREIPWDEIDEHATDYVLSLLALGFDPEEGTLYRQSENRAVQDLAFELGVEANYSELQAIYDFHGGTDVSHMQSVVTQMADILYPQLVDGPKPTVIPVGPDQDPHMRLARDLAARVRYFGVTEAYASFEATPAERELLDRAWEARDSFADEPDRPRCVEAAEWLEAADEAGDLDVAALAFQGGDGDGDSGEHEVLESIAGKLRNAGKEPLRPRVRILDRNATEEAFDALIEGVEGEKRVYDEHVDAFDLSREEAEKLSRDVELDNGGYGFQLPSSIYHRFMTGLTGGKMSSSVPASHISLLDDPEEGYDKVKSATTGGRETAEEQRELGGRADECPVYELYAYLLAGDDDELATEVYEECVGGERLCGGCKEQAAELMEAFLEDHQEKRAEWADKLDELEIELDSPRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q2</accession>
    <name>R4W9Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447772.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02878">
        <property type="protein sequence ID" value="AGN02878"/>
        <property type="gene ID" value="L593_14720"/>
    </dbReference>
    <dbReference type="GeneID" id="16181244"/>
    <dbReference type="KEGG" id="sali:L593_14720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3005"/>
    <dbReference type="eggNOG" id="arCOG07569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135997_0_0_2"/>
    <dbReference type="OrthoDB" id="98919at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15274" checksum="36F40BAEC9511BC1" modified="2013-07-24" version="1">MTLQTALTEEMSESIVSAVRTSLGDTLRSVVYFTPSNFDVLYTRQGLYESTHTVREAKSQLVEFERTGFAEGPVRTMLAQREDGTDIGAYEFTVRFHEDGFVVRILRGDAGVLFTTDSMDVNAFEDAASALTGLLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T7</accession>
    <name>R4W9T7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446668.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09145"/>
    <dbReference type="EnsemblBacteria" id="AGN01774">
        <property type="protein sequence ID" value="AGN01774"/>
        <property type="gene ID" value="L593_09145"/>
    </dbReference>
    <dbReference type="GeneID" id="16182631"/>
    <dbReference type="KEGG" id="sali:L593_09145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1876"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OrthoDB" id="37632at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="343" mass="38116" checksum="A7E7887FBB9F6ABE" modified="2013-07-24" version="1">METRKVQRLGPSTLAMTLPAEWAGEHNVEKGDEVSLRTSGKGTLTVLPESASGEESEAIIHADDLGADAVERAIVAQYVLGRRVIRVEQTEGALDSETINAVYRAETQLMGLGVIEETPESIAIRCSVDPEDFTLDNLLERLESTGSTMRGEAVKALARGNPDLAERALNRERQANKIFVLLLRLIFTAYQNPNLARAVDLDSGFPLIGYRSIAKNLELTADNAEDIAEIVLDAEDNQLAIDDAAMRRIREFTDQVDEITEIAVQAAVERDYNRTIEVRERFQELRDRESEILDDLPEMDNEDLLQVREVLVSLGQTAEYAMRNAEIAANLALNEESDHTTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W4</accession>
    <name>R4W9W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446803.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09820"/>
    <dbReference type="EnsemblBacteria" id="AGN01909">
        <property type="protein sequence ID" value="AGN01909"/>
        <property type="gene ID" value="L593_09820"/>
    </dbReference>
    <dbReference type="GeneID" id="16182820"/>
    <dbReference type="KEGG" id="sali:L593_09820"/>
    <dbReference type="HOGENOM" id="CLU_207582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="5765" checksum="4585C2A3C57394F6" modified="2013-07-24" version="1">METTQTDKGVGLGILFVLLALAGAGGMLASETSTEIAAAGFAAAVAAGSVAIVVIHAYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y7</accession>
    <name>R4W9Y7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps17E</name>
        <name evidence="4" type="synonym">rps17e</name>
        <name evidence="5" type="ORF">L593_10395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446918.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10395"/>
    <dbReference type="EnsemblBacteria" id="AGN02024">
        <property type="protein sequence ID" value="AGN02024"/>
        <property type="gene ID" value="L593_10395"/>
    </dbReference>
    <dbReference type="GeneID" id="16182225"/>
    <dbReference type="KEGG" id="sali:L593_10395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2143"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176720_1_0_2"/>
    <dbReference type="OrthoDB" id="128227at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6949" checksum="376E44E9CC820005" modified="2013-07-24" version="1">MAIKPAYVKKTGEILMERYPEALSTDFEHNKEAVTELTNIESKGVRNRIAGYIARKQAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA71</accession>
    <name>R4WA71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447338.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12525"/>
    <dbReference type="EnsemblBacteria" id="AGN02444">
        <property type="protein sequence ID" value="AGN02444"/>
        <property type="gene ID" value="L593_12525"/>
    </dbReference>
    <dbReference type="GeneID" id="16180003"/>
    <dbReference type="KEGG" id="sali:L593_12525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2571"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_2_2"/>
    <dbReference type="OrthoDB" id="57446at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="26855" checksum="EDAA5D973F67A462" modified="2013-07-24" version="1">MPDLVSIGVDGLDSILNGGITEHSTVLVSGNPGTGKSILGLQYLYTGVQNADEDGIYVTFEEDAEDLRLAAESIGFDRWGEYVDDGSITVLDKKEMLRDQEFSRAVELLLEIVQEGGYDRLVLDSLTMFELFFEDEHERRVYLLKFSDILKANDLTSLLISEQEAVFPETDLDLENFLTDGNVYLIQTPTDSGVSRYVWVSKMRKQDIDTDIFPMEIGDGGITVHEQAGGFSLVDRQGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA82</accession>
    <name>R4WA82_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SpoU_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447393.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12800"/>
    <dbReference type="EnsemblBacteria" id="AGN02499">
        <property type="protein sequence ID" value="AGN02499"/>
        <property type="gene ID" value="L593_12800"/>
    </dbReference>
    <dbReference type="GeneID" id="16180227"/>
    <dbReference type="KEGG" id="sali:L593_12800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2626"/>
    <dbReference type="eggNOG" id="arCOG01018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_2"/>
    <dbReference type="OrthoDB" id="93855at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="259" mass="28361" checksum="B2600846A69E514A" modified="2013-07-24" version="1">MSDRQAASSGEGGAGAPAVAVVDPQTPGNVGTIARAMKNFGFSELLLIDAPELDPEGEAYGFAGQAREDILPDHERPSFEDLIEHYYTVGFTATTNENATSHVRYPFATPAELAEELTDVDAPVCFVFGREDNGLTNEELSRIDRICAIPASADYPVLNLGQAATISLYELRGLAMDETQLPDPDHDRAAEGEIERLYDHFEDFLASNGHPKEKRPKAGRMFRRLIGRAHPTNREASTLTGIFRRGAQFADPPEEAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA99</accession>
    <name>R4WA99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447478.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13225"/>
    <dbReference type="EnsemblBacteria" id="AGN02584">
        <property type="protein sequence ID" value="AGN02584"/>
        <property type="gene ID" value="L593_13225"/>
    </dbReference>
    <dbReference type="GeneID" id="16180879"/>
    <dbReference type="KEGG" id="sali:L593_13225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2706"/>
    <dbReference type="eggNOG" id="arCOG06238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135433_0_0_2"/>
    <dbReference type="OrthoDB" id="131219at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="13865" checksum="BAB3903D01DD552C" modified="2013-07-24" version="1">MADDSEEHDEEGVENESEDSSEETSFRERVEEIREQRAEEGDDERRERMEEMMGGGGGPGGMGGGGNPFAQMMGGMMGGGGGPGGMGGGPGGPGGESAGNEELTREVRQLRDEVRDATRQLQRIADALEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB3</accession>
    <name>R4WAB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twin-arginine translocation protein, TatA/E family subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_13575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447548.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13575"/>
    <dbReference type="EnsemblBacteria" id="AGN02654">
        <property type="protein sequence ID" value="AGN02654"/>
        <property type="gene ID" value="L593_13575"/>
    </dbReference>
    <dbReference type="GeneID" id="16179868"/>
    <dbReference type="KEGG" id="sali:L593_13575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2779"/>
    <dbReference type="eggNOG" id="arCOG02694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_3_3_2"/>
    <dbReference type="OrthoDB" id="131103at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9855" checksum="8119365CF54F5AC0" modified="2013-07-24" version="1">MVVTPLFGIPMGPELVVILLIAILLFGANKIPKLARSTGQAIGEFEKGKTKAEQELEDIRNGETDLTEIDAEGESTTETESSGTSTEESGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC6</accession>
    <name>R4WAC6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ORF">L593_13900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447613.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13900"/>
    <dbReference type="EnsemblBacteria" id="AGN02719">
        <property type="protein sequence ID" value="AGN02719"/>
        <property type="gene ID" value="L593_13900"/>
    </dbReference>
    <dbReference type="GeneID" id="16180940"/>
    <dbReference type="KEGG" id="sali:L593_13900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2844"/>
    <dbReference type="eggNOG" id="arCOG04077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OrthoDB" id="119723at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="6968" checksum="8C5F87A8385DBB6F" modified="2013-07-24" version="1">MADDRLVCRECHSVVDPDVDACPTCGSSSLTEDWAGYVIIAHPEESEIAEAMGVTEPGAYALKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG6</accession>
    <name>R4WAG6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="7">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="7">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">menA</name>
        <name evidence="8" type="ORF">L593_14925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14925"/>
    <dbReference type="EnsemblBacteria" id="AGN02919">
        <property type="protein sequence ID" value="AGN02919"/>
        <property type="gene ID" value="L593_14925"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3049"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_1_2_2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="29099" checksum="641AFC5978AF4521" modified="2013-07-24" version="1">MIVGTAVAIQAELFAPLPALAALVGALLIQIGTNFANDYYDAVSGVDSEDREGFTRATNAGLIPPRQVKLAAFGTFSLAIVLGVYLVYVGGLPIVIVGLASVASGYAYAGGPALGSKGLGDLFVFVFFGLVAVTGTTYVQAAAELAEPPIVAPPSGAIVPAAVVASLAMAGLSTAILVVNNVRDLETDRAAGKRTLAVLIGYRWSRVEFAGLLALAYFVPIALFVGFDYSVGVLLPLLTLPLGIAVTRTVWTHTDGEALNPALERTGQLLFAYAVAFAIGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAH5</accession>
    <name>R4WAH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447858.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02964">
        <property type="protein sequence ID" value="AGN02964"/>
        <property type="gene ID" value="L593_15150"/>
    </dbReference>
    <dbReference type="GeneID" id="16179843"/>
    <dbReference type="KEGG" id="sali:L593_15150"/>
    <dbReference type="eggNOG" id="arCOG05724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646566_0_0_2"/>
    <dbReference type="OrthoDB" id="58563at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40670" checksum="BFECD7EE0F26B90E" modified="2013-07-24" version="1">MSDPLASLSALADRVDRARGDGSLESERAVQLRAVEPLLETLGWDVRGREVVPDASVDAVSVDYLLAIDSTPALVVETVPPGTDVRESTTALARVIDDDTVDRGIVTDGESIVLLVDGDDGVHRRSLPFDALQEHADALGQYHRSVVERSISAAQSGEREAARRLAAERDAVVTSVTQSILDVTGDAVEPTVAAAAESFVDSLAESLESPGSADGTTDGPSRESDATSSVTTPPPEHSTPDTRTEHPDANTERDEVTAVESGASPESEPEIDSQDAGGDGEYVVRFFGGTSSVGAVGTETPRGTTVGTVRYLLENHGLLGSTTLPWRTDDGTVVLAESPGGPNWIALDNDAGNAVYVRPIREPAMARSCIEELATAAGLRVMFQGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS06</accession>
    <name>R4VS06_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lig</name>
        <name evidence="15" type="ORF">L593_00175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00175"/>
    <dbReference type="EnsemblBacteria" id="AGM99989">
        <property type="protein sequence ID" value="AGM99989"/>
        <property type="gene ID" value="L593_00175"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.35"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="14">
        <location>
            <begin position="468"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGM99989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="668" mass="71266" checksum="1A7B3241B60CE431" modified="2013-07-24" version="1">MEFEAFATRAAEIEQTDADLDVIALTADLLEAAEEDLPIVARFVQGRIFPAWQSRTHDIGPSRCYAALARAAEPGVSAETIEDRLADLGDVGDVAASLELGGQAGLDAFAVSGDDGEKGRLVSDVFEEFDAIASASGSGSEDRKEDLLFSLFSDSTPEEARYLSRLVLGEMRIGVGEGTVRDAIAAAFEVTESTVARALQVTNDYGLVAEEARAGGEAALDELGLEVGRPVQAMLAQAGTVTDALEDWKSALVETKLDGARVQVHYEAAEDPPDDLVATTDTDANDGKAREDRVHLYSRNMEEVTEALPEIVDFVAEHVEPPAILDGEVVAVDEDGEPLPFQEILRRFRRKHDVAAAREAVATELHVFDCLHAPRSVHDELGNDGIPTVDAGGSVPEADSGNGSDPDGAVAERSREQAGLGAWAETGGGKREDGTDPGSDGGGAVRGDDGQHESPQSSGVREPGDGPGVDLLDVPLAGRREYLEAVADDGVVEATVTADADEIASLEAEALEAGHEGIMLKNPEAAYTPGRRGKDWRKRKPDVETLDLVVTGAEWGEGRRAELLGTYTLAARTEDDFVEVGNVATGITDEELADLHDLLEPHVRSSEGQAVDIEPAVVFEVGYEEIQRSPTYESGYALRFPRFVTVREDLDSDGADSLERVERIADQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS18</accession>
    <name>R4VS18_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="9" type="ORF">L593_00250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444899.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00250"/>
    <dbReference type="EnsemblBacteria" id="AGN00005">
        <property type="protein sequence ID" value="AGN00005"/>
        <property type="gene ID" value="L593_00250"/>
    </dbReference>
    <dbReference type="GeneID" id="16181068"/>
    <dbReference type="KEGG" id="sali:L593_00250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.50"/>
    <dbReference type="eggNOG" id="arCOG02382">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_2"/>
    <dbReference type="OrthoDB" id="35919at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="198"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="42139" checksum="1D6CFADCF3F7C2DD" modified="2013-07-24" version="1">MSEVLVVDDSQFMRTVLSTVLGEHGYDVVTASDGETAIDAVAEHEPDVITMDVEMPGMGGIEAVEHIMADHPTPIVMLSAYTKEGADSTLDALSRGAIDFLPKPSGEISADIGEVEDELIETIDAVEDADVDSVATSRAAAAARTAADAEAAVLEASATVEQALSSGESSSTTFGAQAGTATSEPSIETSEDSLVPDGFTGSPTIVIGASTGGPRVIERLLSELPVALNARVLIVQHMPASFTDRLSRRLDGFSEYDVREAADGARVAAGEALIARGDYHMEVAYSGPEHCKVRLTESERLHGVRPAIDVTMLSAAREVDEQLVGVALSGMGRDGAQGISTIKGVGGATIAQDEETSPVYGIPKQAISTGDVDRVLPDDEIVEGIVELAIERDDSDPPEVDLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS93</accession>
    <name>R4VS93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444984.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00090">
        <property type="protein sequence ID" value="AGN00090"/>
        <property type="gene ID" value="L593_00675"/>
    </dbReference>
    <dbReference type="GeneID" id="16181972"/>
    <dbReference type="KEGG" id="sali:L593_00675"/>
    <dbReference type="eggNOG" id="arCOG15176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2930354_0_0_2"/>
    <dbReference type="OrthoDB" id="126873at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="6168" checksum="19649B639E79B8E1" modified="2013-07-24" version="1">MNDRRRQYVLLGLALALIVTGTLATGLLPSTAPYQILAGALIVAGFAVGYVGVGAIKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS98</accession>
    <name>R4VS98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Monovalent cation/H+ antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_00700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444989.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00700"/>
    <dbReference type="EnsemblBacteria" id="AGN00095">
        <property type="protein sequence ID" value="AGN00095"/>
        <property type="gene ID" value="L593_00700"/>
    </dbReference>
    <dbReference type="GeneID" id="16179886"/>
    <dbReference type="KEGG" id="sali:L593_00700"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101659_3_0_2"/>
    <dbReference type="OrthoDB" id="119875at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="9">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="19676" checksum="E8637731465036FD" modified="2013-07-24" version="1">MGADDTYVESQVIMTTVRVVAPFAFTYGLFLTFHGGGSPGGGFQGGAVIGTTVLMIAFAFGIEPTRDWLSNRVVVGLASGGVLAFALIGLVPLLVDGRFLEHAVFDEEFGLYHGKKYALEGVEIVGIAPIVAAIVIGLFFAIAAGFTGDVDAWHPAGPEGPPGTETTPGAGGGEAGATAAGDGSDRDAATGGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSK9</accession>
    <name>R4VSK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445084.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01185"/>
    <dbReference type="EnsemblBacteria" id="AGN00190">
        <property type="protein sequence ID" value="AGN00190"/>
        <property type="gene ID" value="L593_01185"/>
    </dbReference>
    <dbReference type="GeneID" id="16180747"/>
    <dbReference type="KEGG" id="sali:L593_01185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.241"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="37378" checksum="F61599A3E7F2C6CF" modified="2013-07-24" version="1">MHQRRLGSTDQYVSEVGLGTWNIGGSWGDVSDETGREVVRAAIDAGIDFVDTADVYGDGRSESHIGTVLEERDAYDDVFVATKTGRRLDPHEPERYNYETLRPQVERSLENLGVETIDLLQLHCPPTEAYYQPDTFEMLERFEEEGIIEQAGVSVEKVEEAEKAIEYDVVESVQIIFNPFRQRPKERFFRAANRYDVGIIVRVPYASGLLTGALDRDQEFAEDDHRNFNREGEAFDVGETFAGVPYETGHDALEAMEPHLPDDRSTAQATLRWILDHDQVTTVIPGTTSPAHVESNAAVSEQPRLSHEVHGAIRDVYEEYVYEHVHHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT75</accession>
    <name>R4VT75_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Adenylate kinase</fullName>
            <shortName evidence="5">AK</shortName>
            <ecNumber evidence="5 7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adk</name>
        <name evidence="9" type="ORF">L593_02295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5 7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445304.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02295"/>
    <dbReference type="EnsemblBacteria" id="AGN00410">
        <property type="protein sequence ID" value="AGN00410"/>
        <property type="gene ID" value="L593_02295"/>
    </dbReference>
    <dbReference type="GeneID" id="16180161"/>
    <dbReference type="KEGG" id="sali:L593_02295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.465"/>
    <dbReference type="eggNOG" id="arCOG01046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_2"/>
    <dbReference type="OrthoDB" id="55175at2157"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="8">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="23095" checksum="10602A05A87E798C" modified="2013-07-24" version="1">MSQPKILLLGAPGAGKGTQSSNLVEEYGVEHVTTGDALRANKDMETEHGTPRSFMEAGELVPDPVVNEIVQAALDDADGFVLDGYPRNLDQAEYLAEITDLDVAAYFEVADEELIDRLTGRRVCEDCGANFHVKYAPPEEEGVCDECGGDLIQRDDDTEETARERLRVFEENTLPVVEFYDEEGDLARIDGEQAPDEVWADLEAAIEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT96</accession>
    <name>R4VT96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445329.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02420"/>
    <dbReference type="EnsemblBacteria" id="AGN00435">
        <property type="protein sequence ID" value="AGN00435"/>
        <property type="gene ID" value="L593_02420"/>
    </dbReference>
    <dbReference type="GeneID" id="16180194"/>
    <dbReference type="KEGG" id="sali:L593_02420"/>
    <dbReference type="eggNOG" id="arCOG02909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069298_0_0_2"/>
    <dbReference type="OrthoDB" id="64764at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016954">
        <property type="entry name" value="Uncharacterised_Vng0742h"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030471">
        <property type="entry name" value="STR_Vng0742h_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DICT" evidence="1">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="26504" checksum="E4B58CCAB8CD715C" modified="2013-07-24" version="1">MTTLDSLLERVRDRHHHFTVYRGDEETDLPDRFATHAVNVDVERLPSGGPGPFVVIEADGEFVGAIGERELDWLLEPPIARPGESPGVSEGYRVLFDVLDETVFRALSRRQLLAVSREIEDRAYRVGIGTLAVGFQTLSNFESQADLYRELATATALDVHVFGAPDWAPPDIPGITYHRNSGQAQERHWVLGFEGGLDQLQACGLVAQEQTDYYEGFWTDDEGLVDEILTALGVHGTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTE7</accession>
    <name>R4VTE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445384.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02695"/>
    <dbReference type="EnsemblBacteria" id="AGN00490">
        <property type="protein sequence ID" value="AGN00490"/>
        <property type="gene ID" value="L593_02695"/>
    </dbReference>
    <dbReference type="GeneID" id="16180306"/>
    <dbReference type="KEGG" id="sali:L593_02695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.546"/>
    <dbReference type="eggNOG" id="arCOG04232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OrthoDB" id="8357at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="42"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="560" mass="61900" checksum="605C36DA157123D5" modified="2013-07-24" version="1">MFDEEDLAAIRESREEWKAEHVEPTVDRFGERKDEFRTDTGGQSVDRLYTPNDVADLDYEADLGFPGEEPYTRGVYSTGYRGRLWTMRQYAGMGTAEETNERFHYLLDEGQTGLSLAFDLPTQMGYDSDDAMAAGEVGRSGVAIDSLRDFETVFDGIPLDDVSTSMTINAPASVLLAMYVALGDQQGVDREELRGTIQNDVLKEYVARNTYIHPPEPSMRIVTDVFEFAAEEIPNFNTISISGYHIREAGSTAAQEIAFTLGNGLEYVEAAIDAGLDVDEFAPQLSFFFASYNNILEEVAKFRAARRLWHSLMEERFGAEQPASKQLKFHTQTAGSTLTAQQVENNVVRVAYQALAAVLGGTQSLHTNGKDEALALPTEESVRTALRTQQILAHESGAADTIDPLAGSYYVESLTDDLEAEARDILDSVDQRGGMLDAIDDGYVQREIQDVAYDRQQEIEAGDRIVVGVNEFTVEEGGQEMDLEEVTEEDERRQIERLESVRADRDEEAADAALATVRDAARGDRNLMPPLIEAVKAEATVGEICGVLREEFGEYGAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTI4</accession>
    <name>R4VTI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445434.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00540">
        <property type="protein sequence ID" value="AGN00540"/>
        <property type="gene ID" value="L593_02945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180450"/>
    <dbReference type="KEGG" id="sali:L593_02945"/>
    <dbReference type="eggNOG" id="arCOG04682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896066_0_0_2"/>
    <dbReference type="OrthoDB" id="57234at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="318" mass="34637" checksum="D82F7FBDC535EC65" modified="2013-07-24" version="1">MTRSVHDALASHPVETTVHRRLHDVRPHEVFEVTYDGQRVVCKVAQHPLGDPELEARILQFVAAETPVPVPPIMAVGSDHFVAGWCRDLPADPTVDETRSRAMGAGLARLHESASERFDAPGHLEAENGSLALDADDRWSDTLVAFLDERRRFLEPRGYGDVATEVLGLVEAFPEAFDDVGDPTLLHGNALPDHVGIDRSADPARVTRVIDFEHALVGPPAFDLLRSIGPTYGPPGATHDPDGRAAFLEGYATVRPLPADLEETFRPLGVVNGVAYLRALHLQRGDRDAPQSVARRARGLAEHVLEAASEVRSALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUA8</accession>
    <name>R4VUA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445679.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04170"/>
    <dbReference type="EnsemblBacteria" id="AGN00785">
        <property type="protein sequence ID" value="AGN00785"/>
        <property type="gene ID" value="L593_04170"/>
    </dbReference>
    <dbReference type="GeneID" id="16181699"/>
    <dbReference type="KEGG" id="sali:L593_04170"/>
    <dbReference type="eggNOG" id="arCOG03067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_1_0_2"/>
    <dbReference type="OrthoDB" id="103666at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="14107" checksum="7BDAF4BC04242919" modified="2013-07-24" version="1">MVRDPFEEADATDLAALLDALSDPDCRELLSAIDSPMTAAELSEETGIPQSTTYRKLDQLSEASLLEELTEIRSDGRHTTRYALAFENVEVGLDEDREFTVEITRPTRSADERLARMWSEVQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM6</accession>
    <name>R4VUM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04880"/>
    <dbReference type="EnsemblBacteria" id="AGN00925">
        <property type="protein sequence ID" value="AGN00925"/>
        <property type="gene ID" value="L593_04880"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.997"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050480_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="439" mass="49434" checksum="9D355D68F01A30A4" modified="2013-07-24" version="1">MPGEEMSNGGSEDPPAERPNVLFVCVDCLRSDFVGTDHADTPFIDSLVERGASYPSTFATATTTTPAVASFMTGRYSEGNGIHSLDEGRLREDVDTLAERFSEAGYETTAMVTGPLVEDTGLDRGFDEYHYRDRTEKLTEEWEAEAADAIESLAESDADDPFFCYLHLWAIHKPIEVPPDFDDPQYGETPYARTLSALDRSLERVCDRLPDDTVIALHGDHGEAITWIHNPVHKLGKYARTGLRYYLGLDTRPIERRIDRFVAERWPRSVPDRFLDDRHGENVADPVANVPFVLSGPGIPEAEVDAQVRQVDVFPTLLDLLDGDDRSATEEGTESIDGESLLSPERVTDRDAYMRACGASLLKRESWARGLRADGKKLVVYPDRDWSPEFYDLEEDPLELYPIDDEDAIEQYRARFPDRELTEGERLEIDGLLEDLGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUX2</accession>
    <name>R4VUX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00555"/>
    <dbReference type="EnsemblBacteria" id="AGN00066">
        <property type="protein sequence ID" value="AGN00066"/>
        <property type="gene ID" value="L593_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.113"/>
    <dbReference type="eggNOG" id="arCOG02264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050976_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="466" mass="49141" checksum="8CBB12EF5A7F2143" modified="2013-07-24" version="1">MRLVQVLIPEGNRASVLDALDEYGIDYAVFDEVGRGDFEAMVQFPVPPSGVEPVLEDLRSAGIEEDAYTIVVPTETVISRRLSALVERFPGLRISREELHARAQDLAPANSTFFSFLLLSTIIATTGLLLDSAATIIGAMVVAPLMGPAISASVGTILDDEQMAARGVKLQVTGLVAAIATAAILGFVLEQTVLLPPALDIRTVPEIAERTSPNVLSLFLALGSGLAGAISVMRGAGSALVGVAIAVALVPPAATAGLGIAFGLPGVAIAAAVLVVVNLLAINLSALTLFYLSGFRPLDAGQYVGVRSSVFSRIVVVGIGIAVLSIVLVGVTLATFYTESVEQEATSEIEREFEEAQFESVELEEVSVDYTTTELLLGEEPQVNVLVGIPRDEPAPPGLAQRLDDRITEATGQDVVVRVGYIETQWSEDEPRTEGRPVLSREVASDARWNIPVRPRGPPISESSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUY3</accession>
    <name>R4VUY3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05480"/>
    <dbReference type="EnsemblBacteria" id="AGN01045">
        <property type="protein sequence ID" value="AGN01045"/>
        <property type="gene ID" value="L593_05480"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1119"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="33638" checksum="DA6BAF31E62F46B6" modified="2013-07-24" version="1">MTRRKVLALGGILVLAAAMTLPMLGAGTDLGTIALQSLSIPAGFPVDRFLAHWWVFPASIVFSLVAIGSGVSGALFFSPFFMLFVGLAPAQAIGAGLLTEVFGMGNGLANYVRQGVVDYATAKWLLLGAVPAVVLGALAAHVVPTALLTLAFGGGLLLLGAFLVYYDPPEECVPGECEGAFLRRKNTGRGTTTIETADGETYTYDTCWRPPGLGLATAGGFITGLISAGLPEITTTQLIVRCRLPPRVAIATSVFVLGIAAIAGAAVHALAATPVWFVVAWSIPGVLVGSTIGTRVGKYVPSDVMEPVLGVVFGIVGAIVLASELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV92</accession>
    <name>R4VV92_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445080.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01165"/>
    <dbReference type="EnsemblBacteria" id="AGN00186">
        <property type="protein sequence ID" value="AGN00186"/>
        <property type="gene ID" value="L593_01165"/>
    </dbReference>
    <dbReference type="GeneID" id="16180818"/>
    <dbReference type="KEGG" id="sali:L593_01165"/>
    <dbReference type="eggNOG" id="arCOG07589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143273_0_0_2"/>
    <dbReference type="OrthoDB" id="103027at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="122" mass="13842" checksum="183F727BA584AE10" modified="2013-07-24" version="1">MYADLSVWLALLTEDESRIDRAASLLAEHEDDLQVSLVTFVELFLIEESYHFDRERAITAMLDLADFDDDPAILYRASRYRDGGIDTFDAFHAAIADERGVPGEVDGEERTWLRLDGEEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVJ2</accession>
    <name>R4VVJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445160.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00266">
        <property type="protein sequence ID" value="AGN00266"/>
        <property type="gene ID" value="L593_01565"/>
    </dbReference>
    <dbReference type="GeneID" id="16179863"/>
    <dbReference type="KEGG" id="sali:L593_01565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.318"/>
    <dbReference type="eggNOG" id="arCOG04693">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102054_0_0_2"/>
    <dbReference type="OrthoDB" id="75119at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="21660" checksum="974A283A97438946" modified="2013-07-24" version="1">MSAVTDDIDEISGVDLDDDEYEIVQSLVRNKYEAYDSNGDLVFKGKQKMFKMKEEFPFVDANGDELFTVTAGGILDVAGDYTLTDAETGEPIVVLDNNWSFLNDVWKIRHPQNEALVATIELQSVVSELVRRFVPYGTFLPHKYEITDVDDDHVGDIEGQLSLKDTYEVSIDDATDVPRDAVVAAACVIDAIEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVU6</accession>
    <name>R4VVU6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_02150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445275.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02150"/>
    <dbReference type="EnsemblBacteria" id="AGN00381">
        <property type="protein sequence ID" value="AGN00381"/>
        <property type="gene ID" value="L593_02150"/>
    </dbReference>
    <dbReference type="GeneID" id="16180511"/>
    <dbReference type="KEGG" id="sali:L593_02150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.436"/>
    <dbReference type="eggNOG" id="arCOG00494">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_2"/>
    <dbReference type="OrthoDB" id="57885at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="13">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="9">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="36684" checksum="2841869848D7A67F" modified="2013-07-24" version="1">MSTSSDTVRVGLNGFGRIGRNVFRAALDSDTVDIVGINDVMDVDDMAYLLEYDTVHGTTEGVELDGEDIVVDGTAFPTFSEKDPAQLPWDELDVDVAFEATGLFRTHEDAIKHVEAGADKTIISAPPKGEKEVLTVVYGVNHDEYDGQDVVSNASCTTNSISPVAKVLDEEFGIESGVLTTTHAYTGSQNLIDGPKAKRRRGRAAAENIVPTSTGAAQATTEVLPQLEGKLDGMAMRVPVPDGSITDFVVSLEADVTESEVNAALERAAGGELEGVLGYTEDEVVSSDIVGEPYSSIVDAESTMVMGNQVKVLAWYDNEFGFANRMLDLAEYVVAESETEAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW35</accession>
    <name>R4VW35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446324.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07425"/>
    <dbReference type="EnsemblBacteria" id="AGN01430">
        <property type="protein sequence ID" value="AGN01430"/>
        <property type="gene ID" value="L593_07425"/>
    </dbReference>
    <dbReference type="GeneID" id="16182123"/>
    <dbReference type="KEGG" id="sali:L593_07425"/>
    <dbReference type="eggNOG" id="arCOG03825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951936_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="29747" checksum="02443DCEEF41E5BE" modified="2013-07-24" version="1">MVPSTTRRRALAGACSAALAAVAGCSLVDRDEQATVSQSVDASDVDSVAVDSDTGDLAVRGHDGDEIRIHGEKVAASEDGIDALSVTQRRDGDRLVIGTELGDAPELTGWLRTPTLDLRIEVPAGVALDRATTETGDLDVEDVTGSVLASADVGDVYVANVDGAVDARNGTGDVTVRDVTGPIAARTDTGDVSADGEIERLATETGAVRATVRGLAGEPEIRGTAGDVSLAIARSLDVTISASVDAGEVTVHGDGLDTVREAADSTRIVLGDGSRRLEVDVDTGDCSITTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW71</accession>
    <name>R4VW71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446364.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01470">
        <property type="protein sequence ID" value="AGN01470"/>
        <property type="gene ID" value="L593_07625"/>
    </dbReference>
    <dbReference type="GeneID" id="16182170"/>
    <dbReference type="KEGG" id="sali:L593_07625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1563"/>
    <dbReference type="eggNOG" id="arCOG06229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024174_0_0_2"/>
    <dbReference type="OrthoDB" id="6449at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="742" mass="78867" checksum="88449080D6ACE931" modified="2013-07-24" version="1">MALPEHQHEAGFTAVFESLDSTPGVEIIDPIERRRRSLHTPSQVSPEPLDPGAFPIPVETAVAVETASVTTPTAEQVIVRDADGQMLAEVDHGETASFSADAYVLEPTGILRTYLRVEGPVSIAPDGHGTAIDFGSPARVGIGCRSAHERPAATVTTTSDPEDVLAAISTFGSALKTTSPERAFGSFRGHPPAVEVGSELSIPEGLEPPADDLRIEVPPEYRYAFPVAPLAYYLGAPVEPGPEPRLLGDGLDHRLEHAGSFEDGVERTLERIFLLECVTRTEGLYRVDLHERDLLEERLDARGIELPFADLYDAPQAERIAAFLDVPHDLIADLLPDWRNAAQLAPSADGVETLPYLVDDLAVLSVGEPERVSAAVVESGGVQGLLRGGDGGEPTAPALETAGAALADAAVAHDERVRDEGAHDGEARDEGAFVRGSAAADTTFVNPTGLDALERTWVGGGTPIGATKAVPEAYENRIGRTPTTGDVDIAVVCNADEMAAEGDLVDEVYGSRANLPFDVTVHRDLTTDELADVLAEEREFLHYVGHIRADGFECADGLLDVATLDSVGTDAFFLNACQSYDQGMGLVEQGAIGGIVTIRDVVNHGAVRIGRAVAKLLNYGFPLRPALELAREESVVGALYIALGDGSLSIVQTAGGTPMLIDVERRGDEYAVTLDMYGAETGIGGLTIPHVEGIDEYYLASGRSKEIRLDGESLKAFLALDDGPVRFDGQLTWRDEIDLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWA6</accession>
    <name>R4VWA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446404.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07825"/>
    <dbReference type="EnsemblBacteria" id="AGN01510">
        <property type="protein sequence ID" value="AGN01510"/>
        <property type="gene ID" value="L593_07825"/>
    </dbReference>
    <dbReference type="GeneID" id="16182232"/>
    <dbReference type="KEGG" id="sali:L593_07825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1603"/>
    <dbReference type="eggNOG" id="arCOG04628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648272_0_0_2"/>
    <dbReference type="OrthoDB" id="91306at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="162" mass="18439" checksum="C95061EAB97BD956" modified="2013-07-24" version="1">MDDHTRDPDVSPPRSGDPTGWNATAQQWEHATLRRALVHGVRLFNAGEFHESHDCFEDEWYNYGNGTDESRFLHGMVQVAAGAYKHHDFRDDAGMRSLFETALDYLAGLPRDYYGVDLLDVRTKLTQALEDPTAIEGWQLRLDGAVVVAEERDYAYVEALEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWB8</accession>
    <name>R4VWB8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ORF">L593_03100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445465.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03100"/>
    <dbReference type="EnsemblBacteria" id="AGN00571">
        <property type="protein sequence ID" value="AGN00571"/>
        <property type="gene ID" value="L593_03100"/>
    </dbReference>
    <dbReference type="GeneID" id="16180333"/>
    <dbReference type="KEGG" id="sali:L593_03100"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OrthoDB" id="92409at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_S19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16564" checksum="2BC51DC8B7528CA4" modified="2013-07-24" version="1">MTTLYDVPAEDLNEAVAEELADRLEAPEWAQFAKTGADNELPPEQEEFWSHRAASVLRKVATDGPVGVERLSTAYGGTKRGSNRYVVSPPSREDGSKNVIRTILQDLEEEGLVEQAGSEGRIVSDEGSALLDETADAVMEELDRPDLERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWH9</accession>
    <name>R4VWH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446494.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08275"/>
    <dbReference type="EnsemblBacteria" id="AGN01600">
        <property type="protein sequence ID" value="AGN01600"/>
        <property type="gene ID" value="L593_08275"/>
    </dbReference>
    <dbReference type="GeneID" id="16182352"/>
    <dbReference type="KEGG" id="sali:L593_08275"/>
    <dbReference type="HOGENOM" id="CLU_2679094_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="7835" checksum="8B94720A7FE870F0" modified="2013-07-24" version="1">MATDHWGAPVRTPTAVATRDAPLRRLPVDPGRCAIRGPGDQRRLRANRSPSDASQSHATGDRPDAPSQPDGDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWV7</accession>
    <name>R4VWV7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445630.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03925"/>
    <dbReference type="EnsemblBacteria" id="AGN00736">
        <property type="protein sequence ID" value="AGN00736"/>
        <property type="gene ID" value="L593_03925"/>
    </dbReference>
    <dbReference type="GeneID" id="16180725"/>
    <dbReference type="KEGG" id="sali:L593_03925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.798"/>
    <dbReference type="eggNOG" id="arCOG03031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470618_0_0_2"/>
    <dbReference type="OrthoDB" id="3322at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="5">
        <location>
            <begin position="512"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="602" mass="65762" checksum="8612B4300CD7D8DD" modified="2013-07-24" version="1">MPRPPETDEGWYVLHDLRTVDWDAWREAPERERDRAIAEGREYLEDAVAVADADGGDSAVFAVLGHEADLMVVHLRPTLDDLDYLERQFAQTALAGYTERTASYVSVTEASGYTGAEDYFDPDAEADPGIRNYIESRLYPEIPDSEFVSFYPMDKRREPEQNWYDLSFEERAEYMDAHGDIGRSYAGKVSQIISGSVGLDDFEWGITLFADDPTDVKDLLYEMRFDPSSSRFAEFGPFYSGRQFLPADLEPFLAGERVPTTDPSAEDGDAGRSALDEALADLEVEPPADGHAVLVTSEADAEAVQEEVDGLRGNFEHYDTHRGTEVHPTDDGAAVVSVWETSSAADTASGFLAEIAGAVETQVGPVGDAVADGEEESDAASDAAAGDADAQGDGGTAASTDPGIRADLEEQGIYAGTPHGEDVFALVCYSEADVDELAAEVEDLADGFDRYDTHRGTEVYEATDEGRDDAGRDAQPAVVSLWDTEDAAGTASDYLSDLPGIVREAGEGEGFGTMGMFYTVKPEHREDFTEQFDVVGDLLGDMDGHRETTLYANREDPNDMFIASQWASKDDAMEFFRSDAFADTVEWGRDVLADRPRHVFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX70</accession>
    <name>R4VX70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446719.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01825">
        <property type="protein sequence ID" value="AGN01825"/>
        <property type="gene ID" value="L593_09400"/>
    </dbReference>
    <dbReference type="GeneID" id="16182695"/>
    <dbReference type="KEGG" id="sali:L593_09400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1933"/>
    <dbReference type="eggNOG" id="arCOG06211">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139545_0_0_2"/>
    <dbReference type="OrthoDB" id="91380at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="168" mass="17975" checksum="B1784BA06BA35FB9" modified="2013-07-24" version="1">MTAPPAPDLELTPERVAAECEWLLDRGDVIVPLANEVRADLAAAFDTTVDPIDRSDYERVVVETAADGDRAVNVAALVAFLRGMDVEDDYPGFVVDELLGRELAATIAGEQPLRLLAEATFHYADIVHHAGDSAGMDDLDAGLAAGVQTRLPGWDWTEGESPFSVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXJ5</accession>
    <name>R4VXJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446869.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01975">
        <property type="protein sequence ID" value="AGN01975"/>
        <property type="gene ID" value="L593_10150"/>
    </dbReference>
    <dbReference type="GeneID" id="16181105"/>
    <dbReference type="KEGG" id="sali:L593_10150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2092"/>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_1_0_2"/>
    <dbReference type="OrthoDB" id="3249at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="PTHR31983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro81C" evidence="2">
        <location>
            <begin position="522"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1094" mass="117710" checksum="CA30FB315351757E" modified="2013-07-24" version="1">MTSRDFNDRHDDADESSDERGRLPVSRRSVLQAAGAAGAIGGASGITSALSDSNTVSVGSGSYTTEYPGDSTGDMPPTTDELRITDNVDQPIPTNGVWSGMHFAYDPYDETWHEHCNGATVTYPYYADARSEGFRLQIPSTWQGWRDPWDDMENQPAAIEEADFVRMDYQETPRLVIGNTDVSSYADTRTHDHGDWFNTARWGDGTTAPMDVTQVRGCPFVFVEYGGGGADLSLLDETDAALSNANVSVFADQGNVLGLTVEPTQSGHSVQHFGLYAPDGASWSGVGTSSLTSQLAGSGYLTVAVLPDGTESTLDAFEQYAYNFVRDTTVDWNYDEANAAVSTTYAYTLEEKAESTTSGTLSALFPTQWKHTSASFTGDEYWSPRGRMKVVAGSSFSTTLRYPGILPVQPDVGTYDGAQLDQYLQDLRSDYGPYTDQGVPACAYWSGKDFMRNTQVAPIADVRGLTAEQDYFLQALRGRLSTYLDVANNAWTVDGDSFSTADSDEVFYFHDDLGVLQSYPDCEFGGAFAVNDHHFHYGYLVNAAAEVARQDPKWADNYGPMVELLIRDYANWERPDTSNPLDPSTYPKDSFPFLRTFEPYAGMSYAGGINGNDYGNNQESSSEAIAAYAAMVKWGEITGNTELRDAGIWMYTHEVNASREYWFDEVDDSLPANFGSNLGPDELDTEGSGPFKYCSQTWDVGSWRQVYWDTSDPIELYGINNLPIGGHSFYLGYDQTYNENNWDRLLTARDQLVGGPDPYSRWPDGWAAAAWCYRAMSNPSRAIDPNMAGEMPISPTGTSSPYVYYFLHHLNEIGIPDPTVSADTPFYQVFQDSSTGTKTYVAYNASSSTTTVNFSDGTSLDVAANSVGYTTGSGGSSSAPTVDSLSASEVETSDSDAEFDVSWSVGDSDGDLSSVDLTLTDDGDGTTEDSASISVSGSSASGTTRLVAAGDDGTGNSYTLELVATDGTGNTASSTTSVTESEDTSSGNAPTVDSFSISEDNSGGSPHAEFQIDYAVSDADGDLSSVDLTLTDTEDGQVEGSTTVSVSGSSGSGTETLSARKAENDGHTYEAECVVTDANGNTDTATATEVEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXK3</accession>
    <name>R4VXK3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_10200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446879.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10200"/>
    <dbReference type="EnsemblBacteria" id="AGN01985">
        <property type="protein sequence ID" value="AGN01985"/>
        <property type="gene ID" value="L593_10200"/>
    </dbReference>
    <dbReference type="GeneID" id="16180087"/>
    <dbReference type="KEGG" id="sali:L593_10200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2102"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OrthoDB" id="121393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11999" checksum="C9E9F289FBA2F0FD" modified="2013-07-24" version="1">MQFCEECGSMMKADGDVMVCTSCGAEQPRDADEEAAFVSTEEQSTDDVIETEEGADFEGKPTANDVHCDECGHTEAWYTIKQTGAADEPPTRFFKCKECGYRWREYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXQ8</accession>
    <name>R4VXQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-beta-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445940.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05485"/>
    <dbReference type="EnsemblBacteria" id="AGN01046">
        <property type="protein sequence ID" value="AGN01046"/>
        <property type="gene ID" value="L593_05485"/>
    </dbReference>
    <dbReference type="GeneID" id="16180638"/>
    <dbReference type="KEGG" id="sali:L593_05485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1120"/>
    <dbReference type="eggNOG" id="arCOG01267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OrthoDB" id="55074at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="30164" checksum="C877B42072BA100A" modified="2013-07-24" version="1">MSPTSADLTVPELTAADLLVLDDPRFDPDTVAVVTGAASGIGRATSVALAANGLAVVGADVDEDGLETTADLADELDAPGTIHPVPTDLTDDGDVEAMIDAAADYGNLRYVANVAGMQHIASITEFPMERYDLLLDVMLRAPFLIAKRAMPHIRATDDGVGAIGNMSSVHGHVATQDKPAYVTAKHGLHGLTRSIAAEGEGTLRGFSVSVGYVLTPLMVNQIEDTAEERGISERAVVEDVMLGQARTKEMMTPAEVANLFVFGFSQHGTHLNGGDLLWDGGYTTTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXR8</accession>
    <name>R4VXR8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">L593_05535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445950.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01056">
        <property type="protein sequence ID" value="AGN01056"/>
        <property type="gene ID" value="L593_05535"/>
    </dbReference>
    <dbReference type="GeneID" id="16181410"/>
    <dbReference type="KEGG" id="sali:L593_05535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1131"/>
    <dbReference type="eggNOG" id="arCOG07873">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_8_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="529" mass="56028" checksum="41C804AA7CD23F0A" modified="2013-07-24" version="1">MPDEPDEDGDSGSDAEGASSTSGPKDDATDSAPSADPEETPTWDGESWSRPGEEESDSDGGDAEETTADGADALADAEDAPVNGEDSPADAEDSPADAEDSSIDGNGDDGEADSDAADPSAESAGDEAEPPADRRGSGRARMGSRPPPGDRPAKRPSDVADDDANSDEDRVSHHDPDDFGSTTSQPDYATDKLDDDATDARDEDAEHPDAPGTPDDQPTRNPTERAPRGTAHSRAGAGTTDQTDAARTQSDAASTPSTSVTDDGGSGGSSILSGGIGGSAPPDDEEMPLTEHIEEMLTRLAIVVVVAAFATLAAFPFANDIIIEMWYDVHTGTVEACKTAPQSGDCVAPHVYGPLELVLTRIRVAGLAGLLAALPLGVYQTYRFMRPGLYPHERRYYLAAVPFSLVLAIIGMLFAYFVLLPLLFAYFIGYTQGSADLAFQLAETMNLILLMMGMLAIIFQIPLLIMLAIMMGITTRRWLERRRLYFWGLFLGVAVIFGPDPTGMAPFLLMATMVALFEGTLLLLRWTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY35</accession>
    <name>R4VY35_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17p</name>
        <name evidence="2" type="synonym">rps17</name>
        <name evidence="4" type="ORF">L593_11150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11150"/>
    <dbReference type="EnsemblBacteria" id="AGN02175">
        <property type="protein sequence ID" value="AGN02175"/>
        <property type="gene ID" value="L593_11150"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2300"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12693" checksum="FD54376D35F3D8A6" modified="2013-07-24" version="1">MAIGLDVSAPPEPENPEDYDYETCPFHGELSVRGQVLEGEVVSTDMDRTVVVQREYDVPVEKYDRLMKRRSRIPAHVPGVLEGIEEGDTVKIAECRPLSKTKSHVVVDVVSGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYK7</accession>
    <name>R4VYK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446210.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06845"/>
    <dbReference type="EnsemblBacteria" id="AGN01316">
        <property type="protein sequence ID" value="AGN01316"/>
        <property type="gene ID" value="L593_06845"/>
    </dbReference>
    <dbReference type="GeneID" id="16180861"/>
    <dbReference type="KEGG" id="sali:L593_06845"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="176"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="37203" checksum="6DDA9EF493BC807D" modified="2013-07-24" version="1">MSEPPASDSFHVGVIGCGALGRHIAEQFRAEPTASIAAIADVSDAARSEAGEALDVQPADRYEDYAAMLESADLDGVVIATPHALHHEQVAAALDAGLHVLCEKPLVLTVEDAVDLRDRAAAADRTLMVGYQRHLDQAFVRARERYQGGAADDGAAVDSPEIGHVTAEITQPWFDIAPGTWRADPDLSGGGFTVDTGRHVIDALLWVTGLDPVAVDAEMAFRSPGIDERAEIRIEFEGGATAHVSFYGDAQTVREAHHVVDSEGAVEIDGLGWGSRDMRTIDDEETVHEPLLDRGAEPTKAEAFLDAVRSGDAPPATVEDAIRATAVVEAAYESAESGEAVAVSLPASPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYU2</accession>
    <name>R4VYU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446305.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07330"/>
    <dbReference type="EnsemblBacteria" id="AGN01411">
        <property type="protein sequence ID" value="AGN01411"/>
        <property type="gene ID" value="L593_07330"/>
    </dbReference>
    <dbReference type="GeneID" id="16182097"/>
    <dbReference type="KEGG" id="sali:L593_07330"/>
    <dbReference type="eggNOG" id="arCOG00117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072626_3_0_2"/>
    <dbReference type="OrthoDB" id="121016at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="29222" checksum="39F563CB9A36B21E" modified="2013-07-24" version="1">MDPDYSFDLDGEPRELDVSDLERIERFREAGYGGSVADALYDVGLRRTVFDQEFFGINRGQTLVGRALPVKLHTYPKTDDVEDYLEAKWEHEHDGVHPQKRLMRRVEADEDGSVLVFDTGGDMQPAHFGEMSCTLAKAHGARGMLCAGNVRDTRYVQQLEEFPVYTLGTTPNWHGGWEIVEVAQPIHVPGHLSHYVTVRPGDWVFGDLDGVQLIPREVVDEVLLRVEDIYEEETEERRKIEEGMPIDEVYEEYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYX9</accession>
    <name>R4VYX9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="9" type="ORF">L593_07530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446345.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07530"/>
    <dbReference type="EnsemblBacteria" id="AGN01451">
        <property type="protein sequence ID" value="AGN01451"/>
        <property type="gene ID" value="L593_07530"/>
    </dbReference>
    <dbReference type="GeneID" id="16182144"/>
    <dbReference type="KEGG" id="sali:L593_07530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1542"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052778_0_0_2"/>
    <dbReference type="OrthoDB" id="29893at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="40639" checksum="5F0DD7D07AAF3330" modified="2013-07-24" version="1">MNRRHARYPFFESAREAVEAAGVDLGELVGAGDVEETDEEGATADDGGAAVDEGDAMVVARARERVETALSEGHIGTNGETGMHRSTRIELLSYPIARILVSLLDEPMAIEAYARAEASTARQRLAADLPESAPADGFTGGGLGEELGSRGGTAGADDRLSVHDLLGEFGLGDAIEGRDPFLVDVSVYLELARDLEGQDWALVERSLSAGRVPVDRSELYALLERAVADRVADGLPLSVPEPIADGLAEPRDDIEGMLADEEIPLAFDRVEPAQFPPCVDALLERARDGESLPPHSLYALVGFLGATGMDAAAIADLAGGGLDRETVEYQLAHVRDDRGLEYAPPSCATMDAYGDCVNTDERCDTVNHPLSYYEAALEDVGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ14</accession>
    <name>R4VZ14_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative archaetidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="3">4.1.1.-</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="3">Archaetidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="3">Archaetidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="3" type="primary">asd</name>
        <name evidence="6" type="ORF">L593_12830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>archaetidylserine + H(+) = archaetidylethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:51488"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:71517"/>
            <dbReference type="ChEBI" id="CHEBI:134176"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="3">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447399.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12830"/>
    <dbReference type="EnsemblBacteria" id="AGN02505">
        <property type="protein sequence ID" value="AGN02505"/>
        <property type="gene ID" value="L593_12830"/>
    </dbReference>
    <dbReference type="GeneID" id="16180207"/>
    <dbReference type="KEGG" id="sali:L593_12830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2632"/>
    <dbReference type="eggNOG" id="arCOG04470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072492_1_0_2"/>
    <dbReference type="OrthoDB" id="105037at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023470416" description="Archaetidylserine decarboxylase beta chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023470415" description="Archaetidylserine decarboxylase alpha chain" evidence="3">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="3">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21617" checksum="B9EC85CA66AEE1A0" modified="2013-07-24" version="1">MNVAPGGFRYGLTLVAAGAVALLIHPVVTAVLGAAGVAAVWFHRDPNRSIPEDGVLAPADGKISVIRNEEGRLLVGTFMNVHDVHVNRSPLSGTVTSSEHQPGGHRPAFSKESDRNERQILAVETDHGPMTVTLIAGAFARRIHPYVEAGEDLERGERIGHISFGSRVDVLFPPGIEEADLAVEHGESVRAGETVLVESDSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ19</accession>
    <name>R4VZ19_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pilin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447404.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12855"/>
    <dbReference type="EnsemblBacteria" id="AGN02510">
        <property type="protein sequence ID" value="AGN02510"/>
        <property type="gene ID" value="L593_12855"/>
    </dbReference>
    <dbReference type="GeneID" id="16182506"/>
    <dbReference type="KEGG" id="sali:L593_12855"/>
    <dbReference type="eggNOG" id="arCOG02416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1881161_0_0_2"/>
    <dbReference type="OrthoDB" id="110213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="14808" checksum="DC62FAA54E665857" modified="2013-07-24" version="1">MYGDQHLEEGLSGNIQTLIALALVVLVVVVGILLAAGYGGPIWNHFFDDSQPQASFEFSYDQRAETLTVEHAGGNAIPGRQLLVRSGNRTLADFSAYERVDAGDAVTVANVSRSDSIRVVWRKQHRTLVLATWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ30</accession>
    <name>R4VZ30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446400.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07805"/>
    <dbReference type="EnsemblBacteria" id="AGN01506">
        <property type="protein sequence ID" value="AGN01506"/>
        <property type="gene ID" value="L593_07805"/>
    </dbReference>
    <dbReference type="GeneID" id="16182269"/>
    <dbReference type="KEGG" id="sali:L593_07805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1599"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_2"/>
    <dbReference type="OrthoDB" id="80065at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="161" mass="17172" checksum="25AB1D0A17199D0A" modified="2013-07-24" version="1">MPRIAILSDTHIPSRRAALPGFVREELAAADFAIHAGDFDSREALETIRDLAGDLTAVSGNMDRGMDLPRVATRTAGGVTFVVTHGTGSRHDYEERVAGIVREHDPNAVGISGHSHEVLDTEVAGVRLLNPGSATGASTDRTTMYRAEVLDGEIDLELLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZT4</accession>
    <name>R4VZT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447659.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14130"/>
    <dbReference type="EnsemblBacteria" id="AGN02765">
        <property type="protein sequence ID" value="AGN02765"/>
        <property type="gene ID" value="L593_14130"/>
    </dbReference>
    <dbReference type="GeneID" id="16181066"/>
    <dbReference type="KEGG" id="sali:L593_14130"/>
    <dbReference type="eggNOG" id="arCOG02206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144574_1_0_2"/>
    <dbReference type="OrthoDB" id="119103at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043941">
        <property type="entry name" value="EMC6-arch"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19094">
        <property type="entry name" value="EMC6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11122" checksum="0D6FB88ACD34B276" modified="2013-07-24" version="1">MSEEVEERQTHVRAIAITSTAALAGVIAAIVSQALTSGMSPGAAAGSRDAQFALLAIVAVQLPVYHFVFEDWGGFKDVLYVAFMTFILWFVTWGVILTSDASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W025</accession>
    <name>R4W025_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">L593_14620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14620"/>
    <dbReference type="EnsemblBacteria" id="AGN02860">
        <property type="protein sequence ID" value="AGN02860"/>
        <property type="gene ID" value="L593_14620"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2985"/>
    <dbReference type="eggNOG" id="arCOG00455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_4_1_2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="136"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="25662" checksum="7C62D84F8C4B8072" modified="2013-07-24" version="1">MGSALVRGLAQSGDHTVIAYDVDEEALASVSEYSTETTTDLDVATASDIVFVVVKPDIAPGVVEELDLDADQTLVSFAAGVSTDVIEPLTDATVLRVMPNLAAATGNMAAAVTGGELTPEIEALLEEAGVFVEVDEEYMDIATAVNGSGPAFVFYLIQAMQQAGEDAGLDTEDAQVLAAQTFKGAAETVLRSDEPIEDLIDAVCSPNGTTIEGMDVLWNSDVDEELAAAVAAAERRSRELAAESSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0H6</accession>
    <name>R4W0H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446915.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02021">
        <property type="protein sequence ID" value="AGN02021"/>
        <property type="gene ID" value="L593_10380"/>
    </dbReference>
    <dbReference type="GeneID" id="16181047"/>
    <dbReference type="KEGG" id="sali:L593_10380"/>
    <dbReference type="eggNOG" id="arCOG06371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2821022_0_0_2"/>
    <dbReference type="OrthoDB" id="129402at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7428" checksum="419CA972A43B9C0E" modified="2013-07-24" version="1">MATTDNSLNGMTEPCDACGTDTLHEVSVQIMTEAEDSDNAHYSREPYRVRECQRCGERTSQRMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W111</accession>
    <name>R4W111_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447125.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11430"/>
    <dbReference type="EnsemblBacteria" id="AGN02231">
        <property type="protein sequence ID" value="AGN02231"/>
        <property type="gene ID" value="L593_11430"/>
    </dbReference>
    <dbReference type="GeneID" id="16182495"/>
    <dbReference type="KEGG" id="sali:L593_11430"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2358"/>
    <dbReference type="eggNOG" id="arCOG00541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OrthoDB" id="39954at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="223"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="44713" checksum="4A8B3346731C5EC8" modified="2013-07-24" version="1">MELRFLGGAGEVGRSAILVNESLLLDYGMQPATQPQFPVGSIEPEAIVVSHGHLDHVGTIPALLSGDRRPPIHWTPPTRALALTLARDTLKLHGGTYGCPFTETEIARVTQVSQTHGYRESFEAAGHEVTFFDAGHIPGSAHVLIDDGETRLLYTGDFHTDDQRIVAGSTARPDADVLLCESTYSDVEHEARSVVEERFVESVRTTLWEGGTVVVPAFAIGRTQEMLMICEAYDLPCYVDGMGTHVIDIFQDHPAFVRNADALGRAVSHARFVDGRDGQRERIADKNTVIVTTSGMLSGGPAMTYVPAIRDRPVNKIAMTGYQVDGTPGRDLIETGSAEIDGRVMPVAAQVEQYDFSAHADRDGLLSLLEQYRDAEVLINHGDRCSVFAAELADDGFDATAPENGDRIEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1L2</accession>
    <name>R4W1L2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HGPRTase-like protein</fullName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May catalyze a purine salvage reaction, the substrate is unknown.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447405.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12860"/>
    <dbReference type="EnsemblBacteria" id="AGN02511">
        <property type="protein sequence ID" value="AGN02511"/>
        <property type="gene ID" value="L593_12860"/>
    </dbReference>
    <dbReference type="GeneID" id="16182825"/>
    <dbReference type="KEGG" id="sali:L593_12860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2637"/>
    <dbReference type="eggNOG" id="arCOG00030">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126376_0_0_2"/>
    <dbReference type="OrthoDB" id="88302at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01467">
        <property type="entry name" value="Hypx_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026597">
        <property type="entry name" value="HGPRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="52"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="188" mass="20038" checksum="0A2F1F3B6681B6B8" modified="2013-07-24" version="1">MDRLQASLRDAPIVEKDGYHYFVHPVSDGVPTLDPSLLREITVKIVRKAELADVDKIVTPAAMGIHISTALSLTTDVPLVVIRKRQYGLDGETPLHQQTGYGESQMYVNDVHPGDRVVVIDDVLSTGGTLSAVLGALDDIGAEVVDTVAVIKKVGGVTELADDQTVKTLVNVDVVDGEVVIVDEDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1P9</accession>
    <name>R4W1P9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="5">SDH</shortName>
            <ecNumber evidence="2 5">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">aroE</name>
        <name evidence="9" type="ORF">L593_13110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2 5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447455.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13110"/>
    <dbReference type="EnsemblBacteria" id="AGN02561">
        <property type="protein sequence ID" value="AGN02561"/>
        <property type="gene ID" value="L593_13110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180397"/>
    <dbReference type="KEGG" id="sali:L593_13110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2687"/>
    <dbReference type="eggNOG" id="arCOG01033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_2"/>
    <dbReference type="OrthoDB" id="98644at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="6">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="8">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="27984" checksum="FC459A0760AE20A3" modified="2013-07-24" version="1">MDVYGLIGNPVGHSLSPPMHEAGYEELEIDARYVTYEPEDAGAAIEAAADLGIAGLNVTIPFKQDVLDHVEPDETAERIGAVNTVDFSSVGSTNGGRPTGHNTDVAGVRRSFAHHDVDLDGTTAVQIGAGGAGRAIAFALADAGASVHVANRTASKAHDLASDVPRAEGHGLEAVPDLLADADVLANATSVGMDDDVSPVDADALHEDLVVFDAVYSPIETRLLADAAAAGADTIDGAWMLLFQGVAAFERWTGEAAPVEAMNAALRSHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H8</accession>
    <name>R4W2H8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="8" type="ORF">L593_00110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444871.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00110"/>
    <dbReference type="EnsemblBacteria" id="AGM99976">
        <property type="protein sequence ID" value="AGM99976"/>
        <property type="gene ID" value="L593_00110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180904"/>
    <dbReference type="KEGG" id="sali:L593_00110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.22"/>
    <dbReference type="eggNOG" id="arCOG02202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058152_0_0_2"/>
    <dbReference type="OrthoDB" id="23481at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
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        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
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        <location>
            <begin position="354"/>
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        <location>
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            <begin position="110"/>
            <end position="112"/>
        </location>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00006877"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGM99976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="41868" checksum="1A131720694DC2BC" modified="2013-07-24" version="1">MKLAMIGFGQAGGKIVDKFLEYDQATGSGIVRSAIAVNTAKADLMGLEHVPQQNRVLIGQSRVKGHGVGADNELGAEIAEEDIDEIQGAVDQVPVHEIDAFLIIAGMGGGTGSGGAPVVAKHLKRIYTEPVYGLGVLPGSDEGGIYTLNAARSFQTFVREVDNLLVFDNDAWRQSGESVEGGYAEINDEIVTRFGILFGAGEVEAGDEVAESVVDSSEIINTLDGGGVSTVGYAAEDVEPQGGDGGLLSRFTGDDSGADNLDTAHTTNRITSLVRKAALGRLTLPCEIEGAERALLVMSGPPMHLNRKGIERGRKWLEEQTGSMEVRGGDYPVPRSGKVAGVVLLSGVNNVPRIKELQQVAIEAQDNIEEIKQESEQNLEELVEDDEDELEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2N1</accession>
    <name>R4W2N1_9EURY</name>
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        <submittedName>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AGN02966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="475" mass="50925" checksum="78DF914C4EF10B62" modified="2013-07-24" version="1">MNSRGLTPIIGLVLLLGITAIASMGLFVVGVSLADTTQSSAEHEQAEQSMAQLAESGNGIAAGESRRSSFSIEGSTEGQLRADSSLGTINITVTNRSTNTQLLSMERSFGAVIYEASDGTEIAYQGGGVWRQDPDGGSSLVRSPEFHYREDPDPTITFPVVLVRDDFSTSGSTVGEMVAHTSERHYPDRPSHYNPLQDGSVLITIDSEYCQGWEQYFEERTDGSAAEDCDDGEEGELVIQFSVPFDLGSLENGVMIGGGNGRTNDFDGIDNSSDFGNSDEAPSATPLVEAYLEDARNNGEILPADTEIDAGLYYDDGNLSNGNLDFNTTGGDIIIATEQSPSFDEGADYDIIGNNNVTVYSTGDLVGNGGGGGQLGEPGKEDQLRIFFHSDVDQIGHKGQNTDVHALIYAPNAEVLLGRGNDHSLSGALVAEDYDFGTKFDVVPQLMNISIYEQLGDAPFYYLHISETEIHVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2P8</accession>
    <name>R4W2P8_9EURY</name>
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        <submittedName>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN00072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00072">
        <property type="protein sequence ID" value="AGN00072"/>
        <property type="gene ID" value="L593_00585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181622"/>
    <dbReference type="KEGG" id="sali:L593_00585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.119"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="37411" checksum="6CF156860A26C532" modified="2013-07-24" version="1">MTDTPHSTDEPIDATAGEARSAGDAGTDGTTRTDGGTRVRYDVPDTAPTDDRTMQERLLASIPSKGRAARYVIAITIALLWLVPLIGLFMASVRPLSEIIQGWWHLEGMTITFENYEQAWNYQSGPMKQVLFNTAIVTIPSVLVVTLLGTMVAYPFARFDFPLKTFLFFLLIIVMAAPPELVAMGNYNTLRETGLFDTYMGLILVHIGWGLGWVVMFLRNYLLGLPEELEEAARVDGASRYQIFKSIVLPYSAPALVSVAVIQFTWVWNSFFFPLVFMRSQEKKLAPQVLPLMKGRLQIDWGLVAAGSVLTMIVPILLFIALQRYYKQGMVAAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2U0</accession>
    <name>R4W2U0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445041.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00960"/>
    <dbReference type="EnsemblBacteria" id="AGN00147">
        <property type="protein sequence ID" value="AGN00147"/>
        <property type="gene ID" value="L593_00960"/>
    </dbReference>
    <dbReference type="GeneID" id="16179999"/>
    <dbReference type="KEGG" id="sali:L593_00960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.197"/>
    <dbReference type="eggNOG" id="arCOG06343">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485849_0_0_2"/>
    <dbReference type="OrthoDB" id="83890at2157"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010123">
        <property type="entry name" value="PHA_synth_III_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09712">
        <property type="entry name" value="PHA_synth_III_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="20317" checksum="C05A5CA2398F23AD" modified="2013-07-24" version="1">MSEQTTTPPAQESWTAFVENMNEQMVDAFEANVEAQSQFVETWAETLSEGTDDERFGEGVQGYARAYKVWMEAAEDMAEQVAAEGTDVSPDDLRDVWLSSANEAFKEVMSTSAFAAMTGETVEDALELRQAADENAQSTLHALGMATERDIREVGDRLVELERRQHGIEQKLDRVLDALEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2U9</accession>
    <name>R4W2U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_01045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445056.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01045"/>
    <dbReference type="EnsemblBacteria" id="AGN00162">
        <property type="protein sequence ID" value="AGN00162"/>
        <property type="gene ID" value="L593_01045"/>
    </dbReference>
    <dbReference type="GeneID" id="16180821"/>
    <dbReference type="KEGG" id="sali:L593_01045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.214"/>
    <dbReference type="eggNOG" id="arCOG01708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_0_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="405" mass="44392" checksum="B2A205D1A44C593C" modified="2013-07-24" version="1">MFTFDDSDAAAELADRARRLMEEVVLPKERELPGGMGVSDSTVRELREAAREYGVYAPQIAEEHGGMGYEFRDVLPTFEQAGRSILGPLAMRVDAPDEGNMHLLEMQGTEIQKEQYLEPLVAGDIASGFSMTEPLQGAGSDPKMIQTTAEKDGDEWIIDGHKWWTTQGIEADVLLVLARTNPDVHPYEGCSVFVVPAEANGVEVVRDIPHLGGHSLGTGHAEIKFDHVRVPEEHLLGEEGEGFTHVQERLGPARLTHCMRFSGMAERALSIARAYSAEREAFGTTLAEKQHARFEIAERETQVQAARAMVRAAADAITAGQQARTEVSASKVFAARATGAAIDTAVQYCGANGIGRDLPLADFYESVRTFRIVDGADEVHLRTIARELFEDVDEAELEPVLRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3A9</accession>
    <name>R4W3A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CheA histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445311.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02330"/>
    <dbReference type="EnsemblBacteria" id="AGN00417">
        <property type="protein sequence ID" value="AGN00417"/>
        <property type="gene ID" value="L593_02330"/>
    </dbReference>
    <dbReference type="GeneID" id="16180172"/>
    <dbReference type="KEGG" id="sali:L593_02330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.472"/>
    <dbReference type="eggNOG" id="arCOG02381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654911_0_0_2"/>
    <dbReference type="OrthoDB" id="56884at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheC" evidence="3">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="3">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="427" mass="45667" checksum="A1C7F42DE8C88662" modified="2013-07-24" version="1">MRVDVKTLGTFNELANRGASSAASSLAQLSDTETSVEVTSADLVPAGDIADRFDDDATFVGVEIGFEGGMEGSIVLVFDRESAGRLLERIVPEHWDDVDATLDRSTVSEVANIMTGGFVDAWANHFDTRLQLGPPTYISGAAGDVIPGSVPTWDDRRTALTFTSQLQAPRDASGDDPASPDAGIDFHIYMFPERSSFAAVVGEAVPEQEFPISIEKLSAFTEMTKRGAGRAADKLSGMTGIQIDVEVGRTTFVPIPEVSRHAPSAQRIGSVAELQAAPGGFIVILFDEHSAINVGDALLPIETSEPGLTDQHRSAIEEIGNIMTSGFIDGWANTLDRKIQHNPPEIVEDTASATLGSLVDRLGPSQEYAFLLDATVRAAGREINCDLYAIPEEHSFRQVLGEMSMPEARTAASDPDALEPAAYDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3X3</accession>
    <name>R4W3X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445671.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04130"/>
    <dbReference type="EnsemblBacteria" id="AGN00777">
        <property type="protein sequence ID" value="AGN00777"/>
        <property type="gene ID" value="L593_04130"/>
    </dbReference>
    <dbReference type="GeneID" id="16180845"/>
    <dbReference type="KEGG" id="sali:L593_04130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.839"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="OrthoDB" id="25689at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="485" mass="54692" checksum="13E2DF89B8C0D292" modified="2013-07-24" version="1">MNVFVIDVDSLRPDHLGIYGYDKPTSPNIDDFAEDAIRFDRAYVANSPCMPSRAALLSGRHGVSNGIETHGPRSQVLSSPDSWTDYDGDIFDAAPQYRTLPEVFFDAGEAAVAVSSFPRHPSPWFYQLWTDFHHPREPTTGGPGETTDPSRLENFQTPRGSTVTDLAIDALDDLDRRGGDGLCYLQYWDPHAPYLRSDEAVEPFRDGELPPYPTQEQIETHREWDRWRSAADPAFEHSLRHSVYDEVENREALGELIAHYDAEISYVDEQVGRFLDELRSRDLYADSLIVLTADHGEEFGEHGLYREHWSTHDGTQRVPLLVKPPADSAGASDADAAAASAAGESRDALVTNVDYAATIADYADLDASGAWQGASLRPVLEDPETDWRDRIVVDHGLYTAQRAVRTDRWKFVRTYDDGEWDLPERALFDMREDPWEQENLIDEHPEVAAELEREMAVWVEHHVGEEGDELRHVARSGPAGLELYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W440</accession>
    <name>R4W440_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445791.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00897">
        <property type="protein sequence ID" value="AGN00897"/>
        <property type="gene ID" value="L593_04740"/>
    </dbReference>
    <dbReference type="GeneID" id="16181789"/>
    <dbReference type="KEGG" id="sali:L593_04740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.969"/>
    <dbReference type="eggNOG" id="arCOG06352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197624_0_0_2"/>
    <dbReference type="OrthoDB" id="73240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23689" checksum="B29972E9700A853A" modified="2013-07-24" version="1">MTGERGADDIPADRESPVGEPVIRGDEEIAGQRAAEAVQFDPDDPESLASAAEVVLAFATDTVGAEDNIYMLRGAAACAALVRGEGSYKAAAERAGDPVTVAFIRKWARVHDLPRAVRRHVAMGEIAPTAAKHIARVSGPARYDLAWATLDHDLTVRDVRAIASEINDGATPAAALLAHGVEPGALRLQLPMDTYRDLRREAATSGRSPGEVVDDALSEWEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4F8</accession>
    <name>R4W4F8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamine synthetase</fullName>
            <ecNumber evidence="2 6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445996.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05765"/>
    <dbReference type="EnsemblBacteria" id="AGN01102">
        <property type="protein sequence ID" value="AGN01102"/>
        <property type="gene ID" value="L593_05765"/>
    </dbReference>
    <dbReference type="GeneID" id="16181493"/>
    <dbReference type="KEGG" id="sali:L593_05765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1180"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_2"/>
    <dbReference type="OrthoDB" id="47310at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="111"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="49832" checksum="1744CC516ABF24CA" modified="2013-07-24" version="1">MTTGNLTPEEEAVLEEIEEEGIDFLRLQFTDILGTVKNVSIPASQAEKAFEEGIYFDGSSIEGFVRIQESDMRLEPDPATFAVLPWRDSETGAAGRLICDVINTTTGEPFVGDPRTVLKSVLAEAKEMGYSLNAGPEPEFFAFEEDEDGRATTITHDAGGYFDLAPKDLASDLRREIIYNLESMDFEVEASHHEVAEGQHEIDFKYDDGLTTADNIATFRSVVRATAAQNDVHATFMPKPIAHINGSGMHTHLSLFEDGENAFHDADDEFDLSDEAYSFLAGILEHAPAITAICNPTVNSYKRLVPGYEAPIYVAWSDVNRSALVRKPAARVPAASRIELRSPDPSCNPYLALAVMLQAGLDGIERDLEAPDPVRENIYEFDEAKREEYGIETLPANLGQAVEALEEDEVVQSALGPHVSEKFIEAKTAEYNEYIAEVSEWETDRYLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P9</accession>
    <name>R4W4P9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="12" type="ORF">L593_06550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446151.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06550"/>
    <dbReference type="EnsemblBacteria" id="AGN01257">
        <property type="protein sequence ID" value="AGN01257"/>
        <property type="gene ID" value="L593_06550"/>
    </dbReference>
    <dbReference type="GeneID" id="16181798"/>
    <dbReference type="KEGG" id="sali:L593_06550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1336"/>
    <dbReference type="eggNOG" id="arCOG01089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_2"/>
    <dbReference type="OrthoDB" id="97378at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="21939" checksum="6B9E7AD5AB07FA99" modified="2013-07-24" version="1">MTDFPTDGVVYLVTQADASAGRSTVEIVEAAIEGGVDVVQLREKDSPASDRYELGRELRELTADAGVPLIVNDRIDLASAIDADGVHLGDEDLPIAVAREQLGPDVIVGRSVATPEAAVAAEEAGADYLGVGAIYPTDSKEKPPEESDLGAEGIAAVREAVSIPIVGIGGVTSDNAADVTAAGAAGVAVITAITQADDPAAATRDLGDAVAQGVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W546</accession>
    <name>R4W546_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446406.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07835"/>
    <dbReference type="EnsemblBacteria" id="AGN01512">
        <property type="protein sequence ID" value="AGN01512"/>
        <property type="gene ID" value="L593_07835"/>
    </dbReference>
    <dbReference type="GeneID" id="16182235"/>
    <dbReference type="KEGG" id="sali:L593_07835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1605"/>
    <dbReference type="eggNOG" id="arCOG02888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064042_0_0_2"/>
    <dbReference type="OrthoDB" id="75519at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="27847" checksum="09B3300AB97A47BC" modified="2013-07-24" version="1">MRIETLGDGEPEIAVIGGIHGDEPSGQRAVEGLMEDPPDVERPVKLIVVNEEALEAGERYLDEDLNRAFPGDPDADTHEGRLAAKLTDALEGTVALSLHSTQSYPKPFAITREVDDLAREFVPALPVDSLVTAGTFTDGRLLDVADVIEVEAGHQGSERAAENAALIVDAFLKAAGVLPGEVERREHLPVYRLSRSVPKAAATDYDLLAANFERVSPGEPFAAAGGEEVVADEPFYPVLMSAEGYESIFGYAAEHVGSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W558</accession>
    <name>R4W558_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ORF">L593_07935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446426.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07935"/>
    <dbReference type="EnsemblBacteria" id="AGN01532">
        <property type="protein sequence ID" value="AGN01532"/>
        <property type="gene ID" value="L593_07935"/>
    </dbReference>
    <dbReference type="GeneID" id="16182260"/>
    <dbReference type="KEGG" id="sali:L593_07935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1625"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_1_2"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="26739" checksum="B4F782D81863E596" modified="2013-07-24" version="1">MFKAIVDAETLGDALDSVSVLVEECKIHLEEEGLSIRAVDPANVGMVDLELDASAFESYEADGGLIGVDLSRLQDIAGMADKGQLVELELDEETRKLHTQIDGLEYTLALIDPDSIRQEPDIPDLDLSAEIVLEGADIGRAVTAADMVSDHIALGVDPDNALFYVDAEGDTDDVHFELDTGDLIGLQPGDAHSLFSLDYLGDIQKAIPKDAEVTMELGEEFPVKLHFEIAEGQGRVTYMLAPRIQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W579</accession>
    <name>R4W579_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08110"/>
    <dbReference type="EnsemblBacteria" id="AGN01567">
        <property type="protein sequence ID" value="AGN01567"/>
        <property type="gene ID" value="L593_08110"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08110"/>
    <dbReference type="eggNOG" id="arCOG02696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656955_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="159" mass="16507" checksum="4E826E2D22FAACFF" modified="2013-07-24" version="1">MQATRRNVLVILGVLTIAGGALFGTGAFTQVEAQRSVDVSTQGDASAQLGLNITDDSLAGGGQTIEFNEQDLNQNATTRYDASFVVTNNDASTTINSLTIEDGSGNSLVGNTSRVMYFETTGSTPLNSGGGSITYDVVFDTTNGDISEAPNEITIVAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5R7</accession>
    <name>R4W5R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444852.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00015"/>
    <dbReference type="EnsemblBacteria" id="AGM99957">
        <property type="protein sequence ID" value="AGM99957"/>
        <property type="gene ID" value="L593_00015"/>
    </dbReference>
    <dbReference type="GeneID" id="16180648"/>
    <dbReference type="KEGG" id="sali:L593_00015"/>
    <dbReference type="eggNOG" id="arCOG02470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040882_2_0_2"/>
    <dbReference type="OrthoDB" id="28147at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="40796" checksum="5FB3DBF0C9F7460F" modified="2013-07-24" version="1">MSTARRIVLALVLLGVLGLAGCALQFSEDSYPDESEVRDTLDSLETIEADVVTEQRSGGNATAISMHVVQNFDTGEFRVTVQSGPNRGTTMVSNGSRMWYYQPEQNVVRVIAVPDASGNVNRTVEMVAGMYDQLEDGDADGSVGISAAPTVPAAGTSAGSAQDLSIPLGENLSVESSGTEAVDGREARVIHLDAPADSGLVQNATYWIDREWHFPIRSRIGVQVGNDTTVATSTYRNVSYNPSFDGEQFTFDPPATARVVEGVNGTVGQYERYSALASATDRDVPEPSVPDDYEFETGQIQPAGDGQSITLIYSDGSDSFTVTKLAGVDSDLENGERIDVGSKPGRRVSVGANEAVVWTCGGNTYSVVGAGDTVSLHDVATSIGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Z3</accession>
    <name>R4W5Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446916.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10385"/>
    <dbReference type="EnsemblBacteria" id="AGN02022">
        <property type="protein sequence ID" value="AGN02022"/>
        <property type="gene ID" value="L593_10385"/>
    </dbReference>
    <dbReference type="GeneID" id="16180222"/>
    <dbReference type="KEGG" id="sali:L593_10385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2141"/>
    <dbReference type="eggNOG" id="arCOG03065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_4_0_2"/>
    <dbReference type="OrthoDB" id="115195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="13213" checksum="E13B9E9A460211E5" modified="2013-07-24" version="1">MGDERPIEDILDTIGDDHARDVLAAISEEPRPASEVADACDLSLPTVYRRIEMLKEHKLVSSETAVADDGNHYDVFKSNFDGTVIRLRDDEYDVRIYRKENIPDRFSSLWDELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Z7</accession>
    <name>R4W5Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444972.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00615"/>
    <dbReference type="EnsemblBacteria" id="AGN00078">
        <property type="protein sequence ID" value="AGN00078"/>
        <property type="gene ID" value="L593_00615"/>
    </dbReference>
    <dbReference type="GeneID" id="16181515"/>
    <dbReference type="KEGG" id="sali:L593_00615"/>
    <dbReference type="HOGENOM" id="CLU_064244_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="28359" checksum="07E85D870E46A5A5" modified="2013-07-24" version="1">MSTDDGAEHVRLLTRADDGGTAESANDAIRESYEEGILQNVSVMAPTPALEHAADRLAGVEGLCVGVHVTLSSEWVDPTWGPVLGAEEVPSLVTDGGRFYRSPEALFETDPDREEVLAEVSAQVDRIRDVGFDPDYADTHMLIEPASEWFADAFDDLCEREDLINWWGVSPLPGSEGIGSGPEWLLDHLDGVDPGTYLVVGHPAYDDDEMAEFWLPDGEPGRIATERDAQRRMFTDDRVLEYVEEHGVEPIRYDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W624</accession>
    <name>R4W624_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase/DEAD/H associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445017.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00840"/>
    <dbReference type="EnsemblBacteria" id="AGN00123">
        <property type="protein sequence ID" value="AGN00123"/>
        <property type="gene ID" value="L593_00840"/>
    </dbReference>
    <dbReference type="GeneID" id="16182182"/>
    <dbReference type="KEGG" id="sali:L593_00840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.172"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="953" mass="103993" checksum="7CBC65E5BE97D0B2" modified="2013-07-24" version="1">MSRESGADAFSQLGPAVRSALSARGFATPTEPQRLAIPPLADGRHTLVVAPTGTGKTETAMLPVFDAVAEAEHSFGISALYVTPLRALNRDMRDRLDWWGEELDLDIDVRHGDTSDYQRSKQADDPPDVLVTTPETLQAMFTGKKLRRALEDVEHVVIDEIHELAASKRGAQLAIALERLRDLAGPFQRVGLSATVGDPETVGAFLTGGRGCAIREVDVGSRLELDVVVPEVTAEDEALASELMIEEEFASHVRAIRDVVAENESTLIFVNTRQTAEAMGSRFTQLAADEDSGSGGEGVVDVGVHHGSLAKSARIEIEDSFKAGELDGLLCTSSMELGIDVGHVDHVVQYQSPRQVTRLLQRVGRAGHRSDKVSAGTVVATRSDDALEAMAIARRSLDGEVEPAPIHEGSLDVVANQVGGLVEGQGGVHARRAYEIVTAAYPFRDLDKSTFKDVVRELSKNRIVYLDEDADRIESSGTWRYVYENLSMIPDEETYAVEDVASGSQIGTLDERFVATFAEPGAAFIQGGQMWRVTNVDDDDGSLTVSPIEDPSGEIPSWIGEEIPVPRPVAEEVGELRGVAGRQFEHGADRAAVARDLARRYPIEAEHVARALDPIERHAGEAPLPTDEGILIEREGGKIVLNAPYGHDANETLGRMLSALLGQRTGSSVGLDVDPYRIDLEVPGIVDGRDVIAVLEETDPDHVEPLLELSLDRSEALAFRLSQVAEHFGAIKPWQGDSSPPASRLRQYLANTPAYEEAKREVFHEDLDVEAAADLLRSIQRDEIAIELVGGRTPIGTAGRSSNMELLVPQNADAGVVEQVKDRIYGDDVRLFCVHCTEYDRVKPVKRVREEPSCPHCESTMIAALHPWADDAVTAIKADDKDDEQEKLTERAYRSASLVQHHGKPAVIAMAARGVGPDTAARIINKHREAEADFYRDILEQERQYARTKSFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W625</accession>
    <name>R4W625_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02072">
        <property type="protein sequence ID" value="AGN02072"/>
        <property type="gene ID" value="L593_10635"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10635"/>
    <dbReference type="eggNOG" id="arCOG13946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275377_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="216" mass="22665" checksum="907FF2C8CB47A99C" modified="2013-07-24" version="1">MRSKLVALALVAAVALATSGAAAAVGANPAIQDADESTAEHQLPDDYTVEVTDRHGVLSDAEVEAAIQAAWADEEVRSYFENADDVHFDLWAPDADEDRVMVSVAPADEPGQTRVYGNYLVGADTFTDVREPLTANESTTMDVQRTADGNFEVEDGGSLDPAGDEPTNLTADESVDIDVELGSAADGTLTVQYDDANATIVSDDGAVAFSLPDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W660</accession>
    <name>R4W660_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">L593_10935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447026.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10935"/>
    <dbReference type="EnsemblBacteria" id="AGN02132">
        <property type="protein sequence ID" value="AGN02132"/>
        <property type="gene ID" value="L593_10935"/>
    </dbReference>
    <dbReference type="GeneID" id="16182444"/>
    <dbReference type="KEGG" id="sali:L593_10935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2256"/>
    <dbReference type="eggNOG" id="arCOG02201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_2"/>
    <dbReference type="OrthoDB" id="41117at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="9">
        <location>
            <begin position="224"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="391" mass="41447" checksum="1250360496724D86" modified="2013-07-24" version="1">MQDIVQDALENAEQEQREMEVDTDGDEFGDPRIVIVGAGGAGNNTINRLYNIGVDGAETIAINTDKQHLKMIEADTKILVGKSLTNGLGAGGDPSMGERATEMAQGTIKEVLGEADLVFVTAGMGGGTGTGAAPVVSKIAKEQGAIVVGMVSTPFNVERARTVKAEEGLEKLRDEADSIIVLDNNRLLDYVPNLPIGKAFSVMDQIIAETVKGISETITQPSLINLDYADMTTIMNQGGVAVMLVGETQDKNKTDEVVKDAMNHPLLDVDYRGASGGLVHITGGPDLTLKEAEGIADNITERLDASANVIWGARIQESYKGKVRVMAIMTGVQSAQVLGPSTQRQADRSRAELEEVDFDAANNVETVPAGGAQSDGGRDVRDRENGVDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A0</accession>
    <name>R4W6A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445127.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01400"/>
    <dbReference type="EnsemblBacteria" id="AGN00233">
        <property type="protein sequence ID" value="AGN00233"/>
        <property type="gene ID" value="L593_01400"/>
    </dbReference>
    <dbReference type="GeneID" id="16180201"/>
    <dbReference type="KEGG" id="sali:L593_01400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.285"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076814_1_0_2"/>
    <dbReference type="OrthoDB" id="112466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="22247" checksum="C0DFB936BB05CAF3" modified="2013-07-24" version="1">MSDSKSDETVRRAVVLDYLPHGRSDDDRPQYRRSAVGYGVDTEDFHLYEFALADDGETSIGDEIDVAPADAWDDVDHVREIEYDDLPSGANSELDYVIDELLEDESDRFVNVYNEAGPITLRLHQLNLLPGIGDKLRDSILEERKRRGPFESFDDVADRVDGLHDPKGVIRERIFEEIRGDDLKYRLFAVRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D5</accession>
    <name>R4W6D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02237">
        <property type="protein sequence ID" value="AGN02237"/>
        <property type="gene ID" value="L593_11460"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11460"/>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989081_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_peptide_camelysin"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="281" mass="27809" checksum="8C5CD9860852A233" modified="2013-07-24" version="1">MAVVVACLVVGAAGVLAGGGAVALFSDEETVSGSFSVATDYDSGTPATNVTTPGNASTHENGTSAKNESTTAPGNGTRNGTHDRGTNDTALEVAAVSLSGDGELTTGEAATVTVRAVNRANESRELAATLSVDGTATATNTTTVSPNETASLTLSRTLESPGNYTLAAAGRVAGTVTVSAPVADIDVTDASVAQGEVQVNETVPVSATVANDGGANGSVDLVLRANGTAIDSRAVRLGPGERDTVEFDPAFEAAGSYDLTVDGVDAGTVLVENDTDLNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q4</accession>
    <name>R4W6Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447356.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12615"/>
    <dbReference type="EnsemblBacteria" id="AGN02462">
        <property type="protein sequence ID" value="AGN02462"/>
        <property type="gene ID" value="L593_12615"/>
    </dbReference>
    <dbReference type="GeneID" id="16180080"/>
    <dbReference type="KEGG" id="sali:L593_12615"/>
    <dbReference type="eggNOG" id="arCOG13480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101658_0_0_2"/>
    <dbReference type="OrthoDB" id="109950at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="21518" checksum="E96CC8728C3F4693" modified="2013-07-24" version="1">MNFDSIEVSNRVDEGSARLVAKLLLAAGAGAFLGYLLTLLPGLDRIVPQTAVRFAAVLGAIATAVVVVLLFYAAPRIALLAKLSLDGPREVVEEIAAVAQWTVVLVAVLVAHSGFAGVAVPLLDSTVWIYDFAFLLLAFPIVVFVAVHLYRGLDPSAALLATRFAEEETSSESPDDASGDRYTAAESGSDEPKGAAASDSSGGTNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W715</accession>
    <name>R4W715_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13490"/>
    <dbReference type="EnsemblBacteria" id="AGN02637">
        <property type="protein sequence ID" value="AGN02637"/>
        <property type="gene ID" value="L593_13490"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2759"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_659899_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="432" mass="45061" checksum="84DFB213E0C5C520" modified="2013-07-24" version="1">MTDDAPSGSDVDAPAPAPEPGSEAAGATVETDSTGEETTGFDASTWGIALIPLVLLGLVVGGFVLADPTDQFQRGEPTPDVTISHHTVPDDETIVLHVTNNGPEPVRVEQVLVDDAYWDHDVVQDGETKRTIQPRETASVEIPYHWQAGWDYHVVLVLDNGATFGHTIVAIQESPSPDGGMLWTLALIGLFVGVIPVALGMCWFPFIRAMDAKWFHAVLAFSGGVLAFLAVDAGFEALELAERVPGAYEGTLLVALGAVGAALSVQAISAWRESRTDGASGGLYVAYLVAIGIGLHNLAEGLAIGSSFALGRVSLGAFLVVGFMLHNVTEGPAVVAPVARGERERPALWHFVALGAIAGAPVILGGWIGGLSLSPTVSAFFLALGVGAIAQVLWELAGLVRTDGGEIGSTWNVLGFLVGFAVMYATDLLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W763</accession>
    <name>R4W763_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445667.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04110"/>
    <dbReference type="EnsemblBacteria" id="AGN00773">
        <property type="protein sequence ID" value="AGN00773"/>
        <property type="gene ID" value="L593_04110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180826"/>
    <dbReference type="KEGG" id="sali:L593_04110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.835"/>
    <dbReference type="eggNOG" id="arCOG02546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_4_2"/>
    <dbReference type="OrthoDB" id="44682at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="324"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="739" mass="78208" checksum="6715E707A8D59C26" modified="2013-07-24" version="1">MNETRRSILRKASALGALALGASATASAADCSGVSEWDPDTAYNGGDQVTYDGDLFTAEWWTKGSTPDGSKSVWTNEGPCDGGGGGGGGGGGDQADCSGVPAYDSSAAYTGGDQVTHETSLWTAEWWTQGTEPAESENVWTLEGACNEGPTPSFAVSPSNPAPGESATFDASDSSDPDGSISSYEWTIDGTSASGQTVTETFQSAGFYTVELTVTDDSGTSATTSQEITVGDPNLLPSASIDAPDFVNPGEVASFDGSGSSDPDGSISSYEWDFGDGSTGSGATVDHTYSSEGQYTVTLTVTDADGATATAETTVGVGVATGDQRVVAYYRQWSQYEREYLPADIPFDEITHAQYAFGRPEKDGSLNLVGDSYGQQVFYAEEDWQGPDRGKTFSGYARERDDVTFLLSIGGWGDSEYFSPVAQDPAKREKFAQECADLVTKTGIDGVDIDWEYPGGGGCTADSPVCDIDNISQPGDQEKYTLLLEEIRAALDEAQANNPDRNEPYVLTAAQSADPGKLDGLEHGKLSDVLDFVSVMTFDYRGIWSDYTGHQSPLDADPDSPLPKADTWNASSALQYYVDQGWDPQQLNMAVPFYGRSWTDVQQPESGVGSSVDDGLHQPFQGEDEDASGEGSYPGPGQQGTSLGGVWDAFDLVGDGRTGSNPVNLDGANWETYFDEDAASSWSFNAESRLMITHPTTQSMEAKGSWLSNSPYGGTMLWAIGADTKEGTLITALWNALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A2</accession>
    <name>R4W7A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447661.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14140"/>
    <dbReference type="EnsemblBacteria" id="AGN02767">
        <property type="protein sequence ID" value="AGN02767"/>
        <property type="gene ID" value="L593_14140"/>
    </dbReference>
    <dbReference type="GeneID" id="16181099"/>
    <dbReference type="KEGG" id="sali:L593_14140"/>
    <dbReference type="eggNOG" id="arCOG04280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_2"/>
    <dbReference type="OrthoDB" id="61440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="337" mass="35685" checksum="D2473800A7BAD191" modified="2013-07-24" version="1">MTRVAVFGIGSTNFRYAVATPTGEFVTEPVVEPTRPESLAEQVVDAVDDVQTSGPGRIDAVAVSAPGLIDRDAGTIRKLDAPDGRTVPEIHVRRAVRDAHDLPVYVENDCNASVLAEWHFGSAPAIDSVAHLTIGTGIGGGVVERGRLIAGEDAQAGEFGLFSVAPAGDLESTGVTGAWEAYCSGREIPRFVSHILEHEDVTGGSYTADSKLAASLESGEEITAQTVFTHAKDGDAFAESCLERIHRYNAVGVAGICNAFNPGLLTIGGGVALNNDDAIIDGIERYIDEYLFVDRPEIRITVLGDDIGLYGSLATYVARSEEPTGVPERQAIRSEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A4</accession>
    <name>R4W7A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447666.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14165"/>
    <dbReference type="EnsemblBacteria" id="AGN02772">
        <property type="protein sequence ID" value="AGN02772"/>
        <property type="gene ID" value="L593_14165"/>
    </dbReference>
    <dbReference type="GeneID" id="16182558"/>
    <dbReference type="KEGG" id="sali:L593_14165"/>
    <dbReference type="eggNOG" id="arCOG04605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081182_0_0_2"/>
    <dbReference type="OrthoDB" id="75483at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="23700" checksum="FEBE9F344D9AFA8E" modified="2013-07-24" version="1">MVPTLVAAAVAALLAAALLGPAFDRRSLGIVVFAGVVPDLDAAVSLLVFGATNAAFHTLLLPGLLGIALYWDTTRRDRSWLRERYGWRGVRIAWVALAAYVVAGIGLDLFSPEGANLFYPIHDRFYAVTGKLLYSTEDGLVQTYVQIGDEGLLSVGSPGTTANHHVESWLNPTPDTGWDRGAERRLTLVESGWQTIVVVASVAVLAIRGWELSDRLEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E9</accession>
    <name>R4W7E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447766.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02872">
        <property type="protein sequence ID" value="AGN02872"/>
        <property type="gene ID" value="L593_14680"/>
    </dbReference>
    <dbReference type="GeneID" id="16181411"/>
    <dbReference type="KEGG" id="sali:L593_14680"/>
    <dbReference type="eggNOG" id="arCOG01868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141432_0_0_2"/>
    <dbReference type="OrthoDB" id="88437at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="14640" checksum="29D15274AE94B75D" modified="2013-07-24" version="1">MSIDDPDDSAQVYLTEADVAILTGIVGHPYRMPTLPELCWAAGEHGRDLVKRRLNRLVEQGLVEEVTFEDGAPSPKLPDRFFATTDFGSHVLDRRLTPERQRALQESYAKLEKPDRILRYERAPRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7N3</accession>
    <name>R4W7N3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445962.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05595"/>
    <dbReference type="EnsemblBacteria" id="AGN01068">
        <property type="protein sequence ID" value="AGN01068"/>
        <property type="gene ID" value="L593_05595"/>
    </dbReference>
    <dbReference type="GeneID" id="16182156"/>
    <dbReference type="KEGG" id="sali:L593_05595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1144"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695609_0_0_2"/>
    <dbReference type="OrthoDB" id="40216at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
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        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="39928" checksum="4512A73D22FB8B6E" modified="2013-07-24" version="1">MAVTFWALVGLATIAGLSMAWALGANSNSPPFAPAIGANAVSTMRAAFLIGILAALGALTQGGSISETVGSGLILGVDITPLAATAGLLTAAAFMGFGVYSGYPVPAAFATTGAMIGVGLSLGGDPATDTYREIVTFWLLVPPMSGGLAFGTATMLRRDEVPETVGVPLLAAVVGGIVSRIRLGVIPSAPGESQGSLAGFAARAVGGPVVGDVDVVGLLATVVLAAVAFAFVRKRIQDSVEGGIRTFLVLLGSLVAFSSGGSQVGLATGPLEYLYGVELGLPAIVLLGLGALGILAGAWMGAPRLLQATSREYAQLGVRRSIAALVPGFIIAQLAIALGIPISFNNIVISGVIGGGLAAGSAGVSRRKIGVTIAFWLITLAGSIGVGFGLYKLLTTVLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W8</accession>
    <name>R4W7W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_06605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446162.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06605"/>
    <dbReference type="EnsemblBacteria" id="AGN01268">
        <property type="protein sequence ID" value="AGN01268"/>
        <property type="gene ID" value="L593_06605"/>
    </dbReference>
    <dbReference type="GeneID" id="16181652"/>
    <dbReference type="KEGG" id="sali:L593_06605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1348"/>
    <dbReference type="eggNOG" id="arCOG02840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_0_2"/>
    <dbReference type="OrthoDB" id="21461at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
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        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
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        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="494" mass="55552" checksum="EB93E211FD68297C" modified="2013-07-24" version="1">MPLHWHRRDLRPADNVGLAAAADAATDDAGTDAPDERADGDLLALFVLDDALLAHAGPPRVAFMLEALAELRGWYRDHGSDLLLAHGDPREVVPEVAVASDVDLVTWNRDYSKIARERDSAVRRELADREIDRASYDDAVCHAPGSILTSEGEHYSVFSYYWRKWAERDPGEPPAAPDADRLASPDRLAAVEAAKLRNLDDPIPGLDDLGVPEPTADVQPGTRADGLDRLHQFCDGPIYEYDDRRDDPAAAATSRLSPHLSFGTLGPREVHAAVEAAKADAPDDDARENSEEYRRQLCWREFYAQVLADNPDMPTTPLKDFQNPIEWRDDPEALQAWKDGKTGFPIVDAGMRQLREEAFMHNRLRMIVASFLTKDLLLDWREGLAWFRERLVDHDPANDAGGWQWAASVGVDAQPYFRVFNPVTQGERHDPDAEYIRRYVPELRDVEPDVIHDWSELSPTQRQRTAPAYPAPIVDHAERREEAIATFERARGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W830</accession>
    <name>R4W830_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446347.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07540"/>
    <dbReference type="EnsemblBacteria" id="AGN01453">
        <property type="protein sequence ID" value="AGN01453"/>
        <property type="gene ID" value="L593_07540"/>
    </dbReference>
    <dbReference type="GeneID" id="16182150"/>
    <dbReference type="KEGG" id="sali:L593_07540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1544"/>
    <dbReference type="eggNOG" id="arCOG04416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145183_0_0_2"/>
    <dbReference type="OrthoDB" id="100319at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012017">
        <property type="entry name" value="UCP004977"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09846">
        <property type="entry name" value="DUF2073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004977">
        <property type="entry name" value="UCP004977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="14115" checksum="D592012DEB5C842F" modified="2013-07-24" version="1">MPEATAPTDDGNGVQIDLISGERMDGLASMEKIRIILDGVHDGNIVILEEGLSPEEESRLIEVTMAEIDPDGFNGIEIETYPQNDARDTSLLGRIMGQEDTAKLTVIGPANQIETLHKDETLISALVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W835</accession>
    <name>R4W835_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07590"/>
    <dbReference type="EnsemblBacteria" id="AGN01463">
        <property type="protein sequence ID" value="AGN01463"/>
        <property type="gene ID" value="L593_07590"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07590"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="330" mass="34736" checksum="4AB241C2C32E52D4" modified="2013-07-24" version="1">MLVATALLAALVLRQVLTTIFLALTVVVVARPLYRRLLNLGIQRHVASAITTLAVFVAVVVVAAPIGFILYARRGDIEDAIETLPDDLTLAYGGASYTVETADVQTYLTDIVSDVAIEVLGNAPQLVLLLTLFTVVVFGVLLGQRQVGKAVDAIVPAGYERVYAALKQRTVHTLQAIYVLQLATGIATFVVAVPVFYVLGYEYYVTLAVICGLLQFFPIIGPSVVLAVLAGYHLAHGDVADAIAIIGLGGVLIAILPDAVVRPYLARAAADMPATLYFVGFIGGLLSLGPVGVIAGPLVVALLAEAVELLAEELRNGQQSELPDSADPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W849</accession>
    <name>R4W849_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpE</name>
        <name evidence="7" type="ORF">L593_01815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445208.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01815"/>
    <dbReference type="EnsemblBacteria" id="AGN00314">
        <property type="protein sequence ID" value="AGN00314"/>
        <property type="gene ID" value="L593_01815"/>
    </dbReference>
    <dbReference type="GeneID" id="16179958"/>
    <dbReference type="KEGG" id="sali:L593_01815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.368"/>
    <dbReference type="eggNOG" id="arCOG00869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120786_0_0_2"/>
    <dbReference type="OrthoDB" id="93762at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="21990" checksum="AF83CB839D4184BD" modified="2013-07-24" version="1">MSLDTVVEDIKGQAHARAEEIEEEAEERAEELLEAAREDADRIREEAEASVEREIEQEREQRISAAQLEAKQERLEARRELLERVHDRVEAELAELEGERREELTAALLESAANELDVDDDVEVYARADDEALVSELCTEYDGFAYAGEYDCLGGVVVESDASRVRINNTFDSILEAVWEDNLQTVSERLFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W866</accession>
    <name>R4W866_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445258.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02065"/>
    <dbReference type="EnsemblBacteria" id="AGN00364">
        <property type="protein sequence ID" value="AGN00364"/>
        <property type="gene ID" value="L593_02065"/>
    </dbReference>
    <dbReference type="GeneID" id="16182062"/>
    <dbReference type="KEGG" id="sali:L593_02065"/>
    <dbReference type="eggNOG" id="arCOG07583">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154327_0_0_2"/>
    <dbReference type="OrthoDB" id="125050at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="13197" checksum="808026FE79E1C79D" modified="2013-07-24" version="1">MTDEAFVARAPLYVESDLTLTFGDNEVPVRSTGDRLFLEFPSISSALGATRGFPTTQRGEFHDVLTAADLALEIRARDRTIATLGAGTRAGPLSRQLGVAPAAIRLGGILSAGWATLNAVADLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W875</accession>
    <name>R4W875_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_02190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02190"/>
    <dbReference type="REBASE" id="65273">
        <property type="entry name" value="M.SspHBORF2190P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00389">
        <property type="protein sequence ID" value="AGN00389"/>
        <property type="gene ID" value="L593_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02190"/>
    <dbReference type="eggNOG" id="arCOG00890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027633_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="51275" checksum="AF34BFB8F977E6C1" modified="2013-07-24" version="1">MATKVGCAQSTAWRRLSQLADIGAVDRHGEELPLTWEARLYVPWTNVSDLPVSWRNAPRGWGNPLHTIAPYIGGFPPALAHYFIKRFSDPSDVVCDPFAGGGTVPLEAILNDRDGWGSDAFEYASTLTQAKCNPMSTPEFEDYIDHVLKKAETIDSPLELLNDDRPPVFFSDYTLKQLLAVREVLRDEETGEANYLNAIISGVLHGPSEMFLSLSTRDTFSGSVDYVRDYAEKHDLERPNREIRTSAMTKQELVSEELDALPDDVSTWIEKSDCRDLPFPDGSVDLLLTSPPYMRVLDYSWNNWLRLWWLDADRESEREELTITESERKYKEFVRGTLMEIERVLTDDGYAVIVVGDVRKVLANRTEYFNTAQLFAEEAVEHTDLIPRRVLNDEYDLDTRNYAMTNQLRYEYSKDAKEEKAMSKLDRCLILSAHQQPLPASDSINVPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W894</accession>
    <name>R4W894_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446482.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08215"/>
    <dbReference type="EnsemblBacteria" id="AGN01588">
        <property type="protein sequence ID" value="AGN01588"/>
        <property type="gene ID" value="L593_08215"/>
    </dbReference>
    <dbReference type="GeneID" id="16182324"/>
    <dbReference type="KEGG" id="sali:L593_08215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1686"/>
    <dbReference type="eggNOG" id="arCOG02012">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_0_0_2"/>
    <dbReference type="OrthoDB" id="35427at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="108"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="38598" checksum="C0E0FBE5F37DBD86" modified="2013-07-24" version="1">MAEATQEFGEWPLKRLMTAVVGSGPKSADDMDRAQAREAFQRILAGEPDDTTLGAFWLANRWKRNTPEELGAYVDVMHEECVDTVAPECDPVDCGANYDGKGRSAILGVAAGIVAAGAGTPVVAHSGDRVPTQKQDAYKHVLDELGVRTELEPQESADMVDETGFGFYYQPAFNPGIDALEDRRDQMGVRSFVNTIETLANPADASVHLGSFYHLAFAKKIVETAQESQEWTPDRVVMFQGMEGYDDIRPGYTKVADWQEGADLDDYEIETAEYGMDFEEADLEVDDVAEDSAAITEAVVTGEREDHFADAVALNAAFRIFAGGDVDSLEDGLDAARDAIADGSAEAVLEDLRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E5</accession>
    <name>R4W8E5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08740"/>
    <dbReference type="EnsemblBacteria" id="AGN01693">
        <property type="protein sequence ID" value="AGN01693"/>
        <property type="gene ID" value="L593_08740"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1791"/>
    <dbReference type="eggNOG" id="arCOG02701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="491" mass="51565" checksum="551F219BA9ABDC17" modified="2013-07-24" version="1">MLFGTACVGFDMTTLAFDGRTGASGDLLLGALLAAGADRAVLAPVEDALPIEYDVETVEEVGISATRVRVLLDDSDGSDGGDGTDSSHGHHDDGEHEHAHHHDRSDEHSHDHGEHDHGHGHDHEHSHHHDSGHDHDHGHDRSHDEAADDGDATPAEGHGPHRTYAEVREIVADLPIPEAAREDALAIFELLGEAEAAVHGTDLDATHFHEVGADDAIADVVGAALLLDDLDVDSVVTTPVAAGGGEDESSHGTYPVPAPAVVELAERADWELEHGPVDRELLTPTGAAILAHVAEGRTRVPPLRVAGSGYGAGGYDLGDRPNVLRAIVGEERGEFECQPISVLETNVDDVAPEVLGDLQDSLAAVGAKDVTIVPTTMKKSRPGHLVKVIVDPADSAAVARTLAEETGSLGVREAGAAHRWVAERRIESVTVEVDGESFPIEVKVGTDADGSIFDVSAEYDDAAAVARETGLAFREVARRAEAAARAGREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R9</accession>
    <name>R4W8R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445763.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04600"/>
    <dbReference type="EnsemblBacteria" id="AGN00869">
        <property type="protein sequence ID" value="AGN00869"/>
        <property type="gene ID" value="L593_04600"/>
    </dbReference>
    <dbReference type="GeneID" id="16181008"/>
    <dbReference type="KEGG" id="sali:L593_04600"/>
    <dbReference type="eggNOG" id="arCOG10802">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198697_0_0_2"/>
    <dbReference type="OrthoDB" id="127447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6858" checksum="C73D16D873CF3FF2" modified="2013-07-24" version="1">MTTEEPSVTSKDALNEELKALLRTAYENGVDVEGGFECRNGVEHPDWDVIVTEVEKNEHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T3</accession>
    <name>R4W8T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446962.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10615"/>
    <dbReference type="EnsemblBacteria" id="AGN02068">
        <property type="protein sequence ID" value="AGN02068"/>
        <property type="gene ID" value="L593_10615"/>
    </dbReference>
    <dbReference type="GeneID" id="16181395"/>
    <dbReference type="KEGG" id="sali:L593_10615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2189"/>
    <dbReference type="eggNOG" id="arCOG04230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068640_1_0_2"/>
    <dbReference type="OrthoDB" id="51434at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039967">
        <property type="entry name" value="MJ1020-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40517">
        <property type="entry name" value="PTHR40517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="272" mass="30153" checksum="1FCE3789E583132B" modified="2013-07-24" version="1">MSEQVEHGDGGHRYDPDAEHAFPDGRVNDVLEMLESDEEVQAYLEAQNVNPVKRKRYNDHGTKHVQIVRHRALCLYDLLKDAGVEFNGAADQGLDEADEAVIVALAATLHDIGHVVHRDEHPYYSIPLAADLLDQFLPQFYDVGDAVRVKGETLHAILTHHTEEEPLTLEAGVIRVADALDMERGRSRIPYETGGRGINTISSRAIKQVSLMPGEEAAVLVEIQMTSAAGVYQVDNLLKAKLQNSGLEEHVRIVAISAQSEEDDQLVERIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V4</accession>
    <name>R4W8V4_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445858.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00964">
        <property type="protein sequence ID" value="AGN00964"/>
        <property type="gene ID" value="L593_05075"/>
    </dbReference>
    <dbReference type="GeneID" id="16181709"/>
    <dbReference type="KEGG" id="sali:L593_05075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1036"/>
    <dbReference type="eggNOG" id="arCOG10187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328370_0_0_2"/>
    <dbReference type="OrthoDB" id="71131at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="903" mass="90425" checksum="41EF531F9FD943F6" modified="2013-07-24" version="1">MAHTPDPDGGDTHEPTADSGGADEEKAEDTRRIDLVTDGTTDPNDGTADPAERGTSDVANDDPSADPAAGSTLVDRRDYMRVLGGAAAAAAGLGALTGSGAAAEYETITVDAGGSYTANLGSGDTLENVLIDVTADGADVHIGADGDGWVIRNVGIRGAIDIGDDSPGGDDPSYEGGYNSVFTVDASSGGSGLIENVYLGDGIEPGVDKSALITATNHDGHIDVRNFNCGGFSTTAFYVSGFGRERTGGTMTIEDSYFANSAGTAHIRPAGNVTIRNCTITNTNEAVYIPRTFGGLDQAMTARGIWTSYSGSTTRVENCDIDVREENTCDAPWDYDGPCQATSVWAGEAPIDLVDSEVRGTVGGNVNQSNVGSAPDLSLPSGVPDSAEVAASGGTASGSDDSTSGDSGNGSGGSAGNVIEIAGGSPTNAVTYTFEVTETVELGSQANDEDSVSGTTAAGVLAGGTDSFTYTGEIADFSASGTVSVLIDGSTVDPATLASDGDYLDDDSTDGSGDETTDSQTLSRSITVSGGMPSDVVEYSFSVSEAVALGDLANSEDEVSGTDASGVLAGGSDSYSFAGEITSFQADGVVGVLVDGETVDPETLGDSTDGSTSEPTSEPTETIALSGGSPSDPDSYAFAVDEVVEKGEDANSEDTVSGTTADGVLAGGTDDYVFASTVTSFEATGDVAVTINGEAVDPAQLGDDGSSGTDDGTDDTTEEPPEPTRSLAVSGGSPSNKIDYSLTVTEVVEEGSNANSEDSASGTSASGVVAGGTDDYAFAGELVSFDATGDVTLTVDGETVDPANYSDSTEQTSTDEPPELTETLVVSGGTFANVVDYSFTVTEAVETGEQANSEDSASGTTASGALAGGSDSYEFAGDLVSFEADGDVTLTVNGETVDPATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X5</accession>
    <name>R4W8X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445913.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05350"/>
    <dbReference type="EnsemblBacteria" id="AGN01019">
        <property type="protein sequence ID" value="AGN01019"/>
        <property type="gene ID" value="L593_05350"/>
    </dbReference>
    <dbReference type="GeneID" id="16181335"/>
    <dbReference type="KEGG" id="sali:L593_05350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1093"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="30846" checksum="1B85236FAA720CF1" modified="2013-07-24" version="1">MGADSDAAFDGDVWFVTGTSRGMGREFAAAALDAGHAVVATGRDTGAVTEAVGEHEALLVAELDVTNPADAEAAAAAAVDRFGRIDVLVNNAGISYKGFFEEMTMAEIEHQLEANLLGQMHVTRAVLPVMRDQRSGHVVSISSGAGLSGFAFSSAYAASKFAVEGWMDALAEEVAPFGIDTTIVNPGFFRTTLTSRESMPFTDPSIDDYAERRAEQMEWWTEQRGEQPNDPARLADALVEIAGEDDPPRRFIAGEDAIELAEERVAELSEQIEAYPELSRSMAYDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z0</accession>
    <name>R4W8Z0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-C4_Topoisom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447087.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11240"/>
    <dbReference type="EnsemblBacteria" id="AGN02193">
        <property type="protein sequence ID" value="AGN02193"/>
        <property type="gene ID" value="L593_11240"/>
    </dbReference>
    <dbReference type="GeneID" id="16181390"/>
    <dbReference type="KEGG" id="sali:L593_11240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2318"/>
    <dbReference type="eggNOG" id="arCOG01304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131576_0_0_2"/>
    <dbReference type="OrthoDB" id="50280at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-C4_Topoisom" evidence="2">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="32072" checksum="20B3F0968B7629F8" modified="2013-07-24" version="1">MPTTTDILGDGGDAIRVLSGDCTVVADGDRREERRGNVCVVIKPDNTVLVHDADGYQPVAWLTRAEAVSCSRASEGGRPTAPRTITGRPTRDVSGGNPAGGRETNDAHAAAPGTGGGTPVGDSIEAGAAFTVDARDGDERLRVVAHTEDGYASYPTTRAGHPVGECPDCEGTLVRSGRSVSCIGCGDRFGLPDGATVRRERCSCGLPRLRVERGAPLDVCLDRDCDPLLDAVEERFDREWDCPECGADLRVIQRGGLLLGCDAYPDCETSFGIPTGTVVDDCACGLPVFELASGRRCLDSACEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W908</accession>
    <name>R4W908_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside deaminase 2 (Cytosine deaminase, guanine deaminase )</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447137.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11500"/>
    <dbReference type="EnsemblBacteria" id="AGN02243">
        <property type="protein sequence ID" value="AGN02243"/>
        <property type="gene ID" value="L593_11500"/>
    </dbReference>
    <dbReference type="GeneID" id="16181799"/>
    <dbReference type="KEGG" id="sali:L593_11500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2371"/>
    <dbReference type="eggNOG" id="arCOG00692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_1_0_2"/>
    <dbReference type="OrthoDB" id="75040at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="44"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="343" mass="36358" checksum="970190EA7539A798" modified="2013-07-24" version="1">MELSGTILRGRDFEPVEGTIYVEDGEISAIEEAPSSDGVDSDRIVLPAFVNAHTHLGDSIAKGAGEGLSLEELVAPPDGLKHRLLRQADPEELIAAMERSLRYMQAGGTGACIEFREGGVAGVEQLRAAADAEGVDLEPVIMGREEIEVLDTADGYGASGANDANFEAERAAAREAGKPFGIHAGEVDASDVDPAMDLDPDFLVHMVHATDDHLDRLDDRQTPVVVCPRSNLVTDVGLPPIADLAERTTVALGTDNVFLNSPSMFREMAFTAKWTGLPSAEVLAMATYRGAEIAGLDWGVLEAGRPAKLCVLDGDTDNLAGAKDPVRAVVRRAGHADVERVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W936</accession>
    <name>R4W936_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Light-and oxygen-sensing transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11925"/>
    <dbReference type="EnsemblBacteria" id="AGN02328">
        <property type="protein sequence ID" value="AGN02328"/>
        <property type="gene ID" value="L593_11925"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2454"/>
    <dbReference type="eggNOG" id="arCOG02388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010703_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="477"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="732"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="946" mass="101892" checksum="88FDFC49F0D606F7" modified="2013-07-24" version="1">MVFNCGPILAIERMPAILLVGSISETATATLADGGYTVEGVDEQLLVDPANGGSDLRGAVTERVEEVDCALVSVCDWDLDAIEILSDTVPNLPILYAVDAEAAGAAGAALAAGADDRVLLNGDRDGDRISRRLTGLVESPERSNGSLPTGQRRSATGRDTPGQYDGIHDHRIGALLEGAQDFMAASSADAVAETAVETAERALGYGIVGVFLQDEDGETTRLAAKSARADELLEGVETKPLEESLLRATLENERTVELDAEALAEQTIESLGGAVLFPLGSHGVLGFGSTDEDAFGEGDRRAGELLAANARSALDRIERVERIETIHGVMREMLDARSPDEVADYAVDAARSILGYRFVTCFMHDEETERLQPVAWTAETDALTDGDIPSPSPGDGAMEAFQSGVVVRRDSAGSSGGIDGGADLPFTSRLHVPIESHGTILVATPGDEPFDESDVQVARLLATNTARALDRVERTHELERLETVFDTVNDMVYVHDEDGYLLHCTPVLADRLGYDRDELIGENVGTLIDKEAEAEGVNLIQELIGEPPGATKTQRLDLSTSDGEEVPVELDISLLPGEEYRGVVGSVRDISDLLAVRERLDSQQDRFEYLFENIPDPVVEGYLDDEATVGSVNTAFEETFGYEESEIAGETLNDVIVPEENLDQARELDERSAAGKVNQAEVERETQYGLREFLFRGVPYEAPDGRMHGFGIYTDITEQKERERHLEVLQRLLRHNVRNEVNVLLAGIDQLEAARQDDSGEIDDEQEAELLATLDETAQDLLTMSQKAKRISRVIDAETDRLGELDAAAITRSVVEQFRHLNTDATIEADLPPECPILGSGAIERAIEELLGNALQHGGTAPTIRLTLTCDDDGAELTVADDGPGIPEAERNVLEDGEITPLQHGSGLGLWLVAHATAASGGTVTFDEAADGARVTLSFRRPNDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W984</accession>
    <name>R4W984_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06560"/>
    <dbReference type="EnsemblBacteria" id="AGN01259">
        <property type="protein sequence ID" value="AGN01259"/>
        <property type="gene ID" value="L593_06560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1338"/>
    <dbReference type="eggNOG" id="arCOG08960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046651_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="418" mass="47681" checksum="F70B527E2F9CCBA1" modified="2013-07-24" version="1">MDALGAEYAPKVAANLEDSILDFWYPRCIDEEHGGYITSYDADGEFAGTSEKQIVTQARFVWFFARLDREGHGDYREAAEQGLEFLIEEMWDDEHGGFYWQVERDGTVTKPNKHMYGQSFGLYALSEFDRAFDSGLSTGGNQAREYAERLVALFDEEAHDDENGGYVEYFEPDWTPILEGRTYLDGIEPDWSTKESDDEELDASFKLMNTHIHLLESVTEYHRATGAGRDQLEELLHICTNTVLRKDVGACTDKYAPDWTPQLGDLALASYGHDLESVWLVMDAVEALGLSQELFEDFYETLWDYSLEYGYDDEHGGFYFFGPIGEPATNRVKAWWVQAEVLTSALRMFDLTGEERYAEVFEETWDFLESYQFDDEVGEWHSGVTDDLEPVGRKGALYKGAYHNGRAMIECLDALGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G0</accession>
    <name>R4W9G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07670"/>
    <dbReference type="EnsemblBacteria" id="AGN01479">
        <property type="protein sequence ID" value="AGN01479"/>
        <property type="gene ID" value="L593_07670"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07670"/>
    <dbReference type="eggNOG" id="arCOG09016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529292_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="18370" checksum="003135C30BF02100" modified="2013-07-24" version="1">MTDDGGGSTGADGRRAAAANGVADAATDAADAASSADAPPPPPGVPDATEIGADVLRGDADGLEERVDDLHDVAQDAREAFEPPEDAAERALAYCRHGLWPVLAVYVDRRGAGAALGQPHHDRLEVALNTWLELYARSYGGDHSFDFSVREAAELFVSTHNVLDVAQLLTDVPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G3</accession>
    <name>R4W9G3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_13495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447532.1">
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    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
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    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
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        <property type="match status" value="1"/>
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    <feature type="domain" description="Plastocyanin-like" evidence="9">
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            <begin position="121"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="312"/>
            <end position="419"/>
        </location>
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            <end position="82"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001960"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="47431" checksum="36FF7C04BB748B34" modified="2013-07-24" version="1">MGGVDRDRAGAITQALEERLSERVDVEPQVDRRAVLGGLSIAGAAGGLMGLAGADEGHDGGSHGSSHGNFGARGEFDGDTLDPHEFLRTFNTGTEGQDDLSQEVYQEDGRTIRHYTIVAQDVEIEIAPGVTFPAWTFQGQVPAPTLRAVEGDLVRIDFVNGSQHAHTMHPHLENHQPEMDGVPQNGTGLVDVGESFRYEWIAQPAGVHFYHCHALPLKEHMHRGMYGALIVDPDPERVREHPREYVNYHGPIDETYTDELVQRARSRNHTYDENDDVQELVMVMNSFDTNFDGENEVYAANTRAFAYAPASTDADDGDYTPGETKHPIEIDRDRPVRIHLLNTTEFDPINSLHTHSQFFDYYDHGTTLFPTHKRIDTIMQCQAQRGILELDYSEHEEGLYMFHAHQSEFSELGWMSFFEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H8</accession>
    <name>R4W9H8_9EURY</name>
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        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfdA</name>
        <name evidence="8" type="ORF">L593_07920</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN01529.1"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="128"/>
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        </location>
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            <begin position="7"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17239" checksum="F99AB8C011BDDE21" modified="2013-07-24" version="1">MSGRGEMQEIQEQIQEVEQQIELVGEEIEGLEDEQDEIDEAVEAVEAIETGETVHVPLGGDAYVRAEVEDADEIIVGLGGGYAAERDQEDAVETLRSKQDTIDDRIDEFEADIDDLEDTLEEMEQQMQQMQQQQMQQQMQQMQGMGGEGEGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J5</accession>
    <name>R4W9J5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447597.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13820"/>
    <dbReference type="EnsemblBacteria" id="AGN02703">
        <property type="protein sequence ID" value="AGN02703"/>
        <property type="gene ID" value="L593_13820"/>
    </dbReference>
    <dbReference type="GeneID" id="16180860"/>
    <dbReference type="KEGG" id="sali:L593_13820"/>
    <dbReference type="eggNOG" id="arCOG06369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2662243_0_0_2"/>
    <dbReference type="OrthoDB" id="125578at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="955DE8E2ED0CB9FB" modified="2013-07-24" version="1">MAARHSEYEVIRRILEEADEPLTAKEILEHLDEDDIDSAHRVATVLGRRADSGDVDVIRDRPYRYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q8</accession>
    <name>R4W9Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447802.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14870"/>
    <dbReference type="EnsemblBacteria" id="AGN02908">
        <property type="protein sequence ID" value="AGN02908"/>
        <property type="gene ID" value="L593_14870"/>
    </dbReference>
    <dbReference type="GeneID" id="16181305"/>
    <dbReference type="KEGG" id="sali:L593_14870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3037"/>
    <dbReference type="eggNOG" id="arCOG01771">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037598_0_0_2"/>
    <dbReference type="OrthoDB" id="33387at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="577" mass="61013" checksum="300746451D0D1CE1" modified="2013-07-24" version="1">MEPSPTQIVVALALLVVTAGIWFYEGRGRWRARLEDRFVLGVPWGTVLVVGSVVAFYLFAQSGLTHWSDPVVYAFVSWSYFYPLGLVTAGFSHGSPAHLIGNMTGTLALAPIAEYAWSHYPRSTYDSDGDPQSGGADAETDGGDDEPWDTDDELLPDQPTGSAARSFVERPLVRALVLFPGALFAIALLTSVYSLGPGLGFSGAVYGIIGFAVVYYPLRTVVGVVAASALGVVWNALANPIVRGTVSSGPPSPPSWAGIGFQAHALGFLLGAFAALALLTKRNRIPSTQRVFFGLVGIGLAMSLWLVVWPGGDDVFYLYRGAGVVALLVVTGLVTVAATSTRSSSWLTKRKGAIGALVLLTVLLALPTVLFGIVAVDDAGIEQSQAIEIQDYTVAYANNTTSGHVPGVDLGEGTEEIFANEVSGVVLISEDREIWTRVVRPDALAHSGNETVVVGGPGWRETVRAQRTGWNVAGNETAFVVDLHHDDETVRSFTSDPLTAGARIDGHAVTVVPTRDAFELRVSNADGTAETVAIPDGNGSTTLGGITITSETEDGVQHVYMETDDSRALVATEETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y9</accession>
    <name>R4W9Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus biogenesis complex ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446928.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10445"/>
    <dbReference type="EnsemblBacteria" id="AGN02034">
        <property type="protein sequence ID" value="AGN02034"/>
        <property type="gene ID" value="L593_10445"/>
    </dbReference>
    <dbReference type="GeneID" id="16180668"/>
    <dbReference type="KEGG" id="sali:L593_10445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2153"/>
    <dbReference type="eggNOG" id="arCOG01818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017428_1_0_2"/>
    <dbReference type="OrthoDB" id="20239at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="305"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="681" mass="70558" checksum="B032F7C8AE4E594B" modified="2013-07-24" version="1">MQDLLDRLFGAGLDSGCACSVSTDGATLAVDATDCDGRLASAPACRAAIADELCTHDVERIRVRSSGVDRYYDEDAVGLLNAAGRFAALAREADPDLAERARTEPLAAAADAGARAPPISAIAAEVGLLDAVRDDDADPFQPAIAPSVADARVRTALPPDAQLRTARELPTGATVRIYDAPGEGAATYHLDPAESDLDESALATLADAYELLAERSDEPAPVAAVRSALEHGTAASRSSPTGDGHDRGYALVDGRPADDGSADPARTDAAPADPARTDDADVRTLAAVLRKHTRGFGVLEDCFADPAVSDVYASGPAAGTPLWVVADGEQLRTNILLGEDGVGAIASTLRRRSGRSFSRASPTLDATAEIAEQTVRVAGVLDPATEGHAFAFRSGGEEAFTLPALVANGTLPPAAAGLLSVAVRRSAAGLLAGTRGAGKTTALGALLWELPATTRSIVIEDTPELPVATYQDRGRDVQPLHTTLEEGPGVTPTEALRTALRLGESAIVLGEVRGEEAAVLYEAMRVGASGETVLGTIHGDGGEDVRERVVGDVGVPESSFGATDLVVTCESYRRPDGERARRVAAIEEVIRGEDGVRFASLFELETAASATDGRARLVPTGRIDRGNSRLLQALTRPGESYAVLREQIDARAEFVGSLADRGTTAPAAVTTAYARRGDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA04</accession>
    <name>R4WA04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447003.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10820"/>
    <dbReference type="EnsemblBacteria" id="AGN02109">
        <property type="protein sequence ID" value="AGN02109"/>
        <property type="gene ID" value="L593_10820"/>
    </dbReference>
    <dbReference type="GeneID" id="16181553"/>
    <dbReference type="KEGG" id="sali:L593_10820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2233"/>
    <dbReference type="eggNOG" id="arCOG08113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058803_1_0_2"/>
    <dbReference type="OrthoDB" id="37909at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="340" mass="36711" checksum="4408E7BBF62EBC2C" modified="2013-07-24" version="1">MRAYLAHRDRLLTISEADGAAAIDSEHLEGRTVECVASHPSAPGRAYVGTFDAGLFRTTDGGATIDRIGTAIEPDAVMAIAIAPRDPDEIWVGTEPSRLYRSRDGGATFEQIEGMDAVPSAEEWAFPPRPHTHHVRWIEPDPADPHRVYVGIEAGTLLVTTDGGETWTDRPPGSRRDNHQLATHPDAPGRVYSAAGDGYAESTDGGQSWTLYQTGLEHRYVWSVLPDPGDPDRVLVTAASGPRSAHSMPGESYCYRRTGHGSYQSSADDGTWERLDGPLSGEGVLRGVLASDGEAGHAYAATNRGCYRSEDFGSSWTRLDVEWPDACREQTARGLAVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA17</accession>
    <name>R4WA17_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="8" type="ORF">L593_11145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447068.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11145"/>
    <dbReference type="EnsemblBacteria" id="AGN02174">
        <property type="protein sequence ID" value="AGN02174"/>
        <property type="gene ID" value="L593_11145"/>
    </dbReference>
    <dbReference type="GeneID" id="16181400"/>
    <dbReference type="KEGG" id="sali:L593_11145"/>
    <dbReference type="eggNOG" id="arCOG00784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107020_0_0_2"/>
    <dbReference type="OrthoDB" id="124913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="14020" checksum="2B01B35408C3ACC8" modified="2013-07-24" version="1">MSLTPASLPRHELVGLPVRVADASDSGMTGIAGRVVAETTSTLSIRGHREGAAGGETRVRQVPKRGTTFEFVLTDEAADGASSPNEGARKGSGTAFKLAADSAAAGESAAHVTVDGARLHAHPAERTETRSDSTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA18</accession>
    <name>R4WA18_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl5p</name>
        <name evidence="4" type="synonym">rpl5</name>
        <name evidence="8" type="ORF">L593_11170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447073.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11170"/>
    <dbReference type="EnsemblBacteria" id="AGN02179">
        <property type="protein sequence ID" value="AGN02179"/>
        <property type="gene ID" value="L593_11170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182338"/>
    <dbReference type="KEGG" id="sali:L593_11170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2304"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OrthoDB" id="97230at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="172" mass="18766" checksum="CD94E8634D870131" modified="2013-07-24" version="1">MSQSEFHEMREPTVEKVVVHMGVGEGGEPLALAEDILGEITSQQPVRTVAKTAEPEFGIRDGDPIGAKVTLRGEDAHEFLETALPIADVSKQQFDDTGNVSFGIAEHTEFPSQEYDPSIGIFGLDVTVNLVRPGYRVAKRDAETRSIPANHRLDPEDAIAFVESTYDVEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA73</accession>
    <name>R4WA73_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447348.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12575"/>
    <dbReference type="EnsemblBacteria" id="AGN02454">
        <property type="protein sequence ID" value="AGN02454"/>
        <property type="gene ID" value="L593_12575"/>
    </dbReference>
    <dbReference type="GeneID" id="16179837"/>
    <dbReference type="KEGG" id="sali:L593_12575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2581"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OrthoDB" id="118816at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01158">
        <property type="entry name" value="SUI1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="97" mass="10684" checksum="F8F5365A5E11BE81" modified="2013-07-24" version="1">MSEVCSTCGLPEELCVCEDVAKDSQEIQIRIDERRYGKEVTIVDGFDPSDVDLDSLSSDLKSKFACGGTVEDGHIELQGNHTGRIEDFLRDKGFNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA83</accession>
    <name>R4WA83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12825"/>
    <dbReference type="EnsemblBacteria" id="AGN02504">
        <property type="protein sequence ID" value="AGN02504"/>
        <property type="gene ID" value="L593_12825"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12825"/>
    <dbReference type="HOGENOM" id="CLU_2748366_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7138" checksum="46E791F060CB6ABB" modified="2013-07-24" version="1">MDSSEQVQVGSSGERRYPLSDGPGSADAGAWTTDRDDDQSTCSIYGNVIRSSTGSTTARPPIGTGTVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF6</accession>
    <name>R4WAF6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">L593_14665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447763.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14665"/>
    <dbReference type="EnsemblBacteria" id="AGN02869">
        <property type="protein sequence ID" value="AGN02869"/>
        <property type="gene ID" value="L593_14665"/>
    </dbReference>
    <dbReference type="GeneID" id="16181386"/>
    <dbReference type="KEGG" id="sali:L593_14665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2994"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_0_2"/>
    <dbReference type="OrthoDB" id="35979at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="234"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="36139" checksum="32100944E6D6EE10" modified="2013-07-24" version="1">MSDGRRTRERERDETESETESVDETVQCPECGGKLVNDEEHGETVCQDCGLVVETDEIDRGPEWRAFDSREKDEKSRVGAPTTKMMHDEGLSTNIGWQDKDAYGRQLSSRQREKMQRLRTWNERFRTRDSKERNLKQALGEIDRMASALGLPENVRETASVIYRRALAEDLLPGRSIEGVATASLYAAARQAGTPRSLDEITAVSRVEKDEIARTYRYVVRELGLEIKPADPEQYVPRFVSELGLSEEVERRARKLLKTAKSEGIHSGKSPVGLAAAAVYAASLLTNEKVTQNEVSRVANISEVTIRNRYHELLEAEGAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG2</accession>
    <name>R4WAG2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Biotin synthase</fullName>
            <ecNumber evidence="3 12">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">bioB</name>
        <name evidence="16" type="ORF">L593_14825</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447793.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14825"/>
    <dbReference type="EnsemblBacteria" id="AGN02899">
        <property type="protein sequence ID" value="AGN02899"/>
        <property type="gene ID" value="L593_14825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181514"/>
    <dbReference type="KEGG" id="sali:L593_14825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3028"/>
    <dbReference type="eggNOG" id="arCOG00658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_2"/>
    <dbReference type="OrthoDB" id="55121at2157"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="50"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AGN02899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="42502" checksum="CB6E1E29F0311A60" modified="2013-07-24" version="1">MVYSTGNTTVDEATERVLAGEQLSRRDGLALIAQPVEDLAPAADYVRSEFGDDTVDACSIVNAKAGNCAEDCGFCAQSVHFDTGIDTYGLLDPEEILAAAKRAERDGAQRFGIVVAEKGIDREARPEEWDRVLEAIRLVRDETDVEVDGSLGILTEEEAEILVEEGLNHYNHNIETSPNFFPEIVDTHSFEDRVRTLEIAKEAGMDLCAGVILGMGESPTDRVDAAIALHDVGVSSVPVNVLNPVAGTELGEKLGDTADISTEEIVKTIAVYRFLHPDARVRLTGGREVNLDVDEQHLPFEAGADGILTGDYLTTHGNDAADDLDVIERAGMEPNMDANEFDPDEVRTRARSDERSDETDGDDEALEPDTAVGTATSKAGDPRNDRGEATNASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAH3</accession>
    <name>R4WAH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease containing a uri domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_15100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447848.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15100"/>
    <dbReference type="EnsemblBacteria" id="AGN02954">
        <property type="protein sequence ID" value="AGN02954"/>
        <property type="gene ID" value="L593_15100"/>
    </dbReference>
    <dbReference type="GeneID" id="16181740"/>
    <dbReference type="KEGG" id="sali:L593_15100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3084"/>
    <dbReference type="eggNOG" id="arCOG04722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_0_3_2"/>
    <dbReference type="OrthoDB" id="120876at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="82" mass="9317" checksum="1F05CECEB770EE9F" modified="2013-07-24" version="1">MADHYVYVLRCSDDSLYTGYTTDPERRVAEHDAGDGAKYTQSRTPVELVYVEEHASRSAALSREHEIKSLSKREKERLVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VRZ3</accession>
    <name>R4VRZ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
            <shortName evidence="1">LP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cofC</name>
        <name evidence="2" type="ORF">L593_00100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59906"/>
            <dbReference type="EC" id="2.7.7.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444869.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00100"/>
    <dbReference type="EnsemblBacteria" id="AGM99974">
        <property type="protein sequence ID" value="AGM99974"/>
        <property type="gene ID" value="L593_00100"/>
    </dbReference>
    <dbReference type="GeneID" id="16180926"/>
    <dbReference type="KEGG" id="sali:L593_00100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.20"/>
    <dbReference type="eggNOG" id="arCOG04472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076569_2_0_2"/>
    <dbReference type="OrthoDB" id="67356at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="21478" checksum="F24737D911E1B2A0" modified="2013-07-24" version="1">MDVAVPFDALAPKTRLGDLFDEAERSAFARTLLDDVVDAVRATGHEPTVYATAPVDVDAAVVVDERGLDPLCADLFGEPPIAVVMADLGLASGEALERLFSADGDVVAAPGLGGGTNALVVRDDAFRTDFHGVSIRDHREIAADEGLAWTAVDSLRLGVDVDERDDLVEVLLHGDGQAAEWLREHGVRVAVRDGRATVVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS43</accession>
    <name>R4VS43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444934.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00425"/>
    <dbReference type="EnsemblBacteria" id="AGN00040">
        <property type="protein sequence ID" value="AGN00040"/>
        <property type="gene ID" value="L593_00425"/>
    </dbReference>
    <dbReference type="GeneID" id="16182808"/>
    <dbReference type="KEGG" id="sali:L593_00425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.87"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066829_0_0_2"/>
    <dbReference type="OrthoDB" id="66448at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="35652" checksum="5596ACF8F541BB37" modified="2013-07-24" version="1">MRSTEPEVRPRDSPSTDVSVLSLVTSDHATFYRQQVEALGRLGVRTEVVPVSGTRAATGDGSERSLVDYLGLVADVRKRDLSAYDLVHANYGLTVPAAFAQRTCPVVLSLWGSDVSGRFGWIGRLGARRASETIVMSSGMAETLRSDCTVIPHGVDLELFEPMDREQALSSVGWAQAAKHVLFPYPSDRAVKNYPLARRLVDVADARLPDDVVLHTLDERVAHERMPVLMNAADAMVLVSASEGSPNTVKEAMACNLPVVARDVGDVRERLRGVEPSVVAEEEQALVDGLVAVLDDRERSNGREHVQELSVDRVAERTLGVYLSAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSG3</accession>
    <name>R4VSG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type antimicrobial peptide transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_00975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445044.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00975"/>
    <dbReference type="EnsemblBacteria" id="AGN00150">
        <property type="protein sequence ID" value="AGN00150"/>
        <property type="gene ID" value="L593_00975"/>
    </dbReference>
    <dbReference type="GeneID" id="16181750"/>
    <dbReference type="KEGG" id="sali:L593_00975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.200"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OrthoDB" id="45576at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="410" mass="43516" checksum="BE682EE8E64BC010" modified="2013-07-24" version="1">MKFFESIRIGWRSITGHKLRSTLTTLGVIIGIASVIVFMMLGGAFQEDVLGDVDVNDEPVMQVSTQTSPDAGTGIINLDAPIYTERDVEQLRAIDGVEYVAPTGDLDASQVTFSGDSITGAVGVTATSPERFQYDGFDSLEEGETFAGPGEAVISDGLTEEFEENVTVGDEIQIALDDGRRINLTVAGIVESNVGAGGGGNNVWTSLEHYQTSVDGPDGNQVTAFGGLEIRASSQDELDSVQAEVTQYLKQDSDAQELKQSDHRIVVQTIDDMIDQFTGILDQITIFIGGIAAISLVVGSIGIANIMIVSVTERTSEIGVMKAVGARSRDVLQLFLLESIILGAIGAVFGVLTGVGLGYLIVNFIGWPVVYPLNWIGIAVAVGIGVGVVSGLYPAWRAARVDPIEALRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT35</accession>
    <name>R4VT35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00360">
        <property type="protein sequence ID" value="AGN00360"/>
        <property type="gene ID" value="L593_02045"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02045"/>
    <dbReference type="eggNOG" id="arCOG04084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680808_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="43755" checksum="6989F4DBD65497E5" modified="2013-07-24" version="1">MVPGRTGGPDTGCEIPILVRMLVGSNDLPLAPEALGMVPEQNDYRGTERAAGLTTGIETASLNDAVEMVHHPVIHAEGRSTHIMAVQFDPLESESLGIMRCIESREGSVNVPGYVDRSVLRLVEPTSPFTAETGDTIEILGSEEVVWGLPEYRTHDFLGFEDPVCCRIPADGPLHLYCTIPFYDAARGTVMYLGHAIGEDLRSLEMTDPVLGPVEDVHAGAKEPAIAPESSAGHRKNLVESVDVEDGTNYSVVRIAIAEEPGSPWEYGPIAFHPADDGDDWCGGHASPGPLLPPSFVDAGDRKRVGILNGREENVMDDERTRYGTFSIGLMIYDYEDGTVEWTSPEPLIRDPTARTITFASAFRQIDPTTGIVYAHVDDSFIRAYIVDAESLTSYLPSSVAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTY5</accession>
    <name>R4VTY5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445579.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03670"/>
    <dbReference type="EnsemblBacteria" id="AGN00685">
        <property type="protein sequence ID" value="AGN00685"/>
        <property type="gene ID" value="L593_03670"/>
    </dbReference>
    <dbReference type="GeneID" id="16180633"/>
    <dbReference type="KEGG" id="sali:L593_03670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.745"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_1_1_2"/>
    <dbReference type="OrthoDB" id="64826at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="104"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="29910" checksum="EFF012CEE476B475" modified="2013-07-24" version="1">MSEEVAPTDRDPDEQRRIVRERYAGIAEDSDSGCCADDGCGDGSGDADTCGDDATGAPDGSDDVGGTDSEQLGYDDEDVASVADGADLGLGCGNPKALADLSVGETVLDLGSGAGFDCFLAADEVGDAGHVIGVDMTPEMVAKARENVAKNDASNVEFRLGEIEHLPVADGTADVIISNCVINLSPAKEQVFAEAFRALRPGGRLAVSDVVQTAPFPEDVRLDPDSLSGCVSGAATVDDLESMLAAAGFESIAIAPKDDSEAFISEWDDERNLEEFLVSATIEAEKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU65</accession>
    <name>R4VU65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00735">
        <property type="protein sequence ID" value="AGN00735"/>
        <property type="gene ID" value="L593_03920"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03920"/>
    <dbReference type="eggNOG" id="arCOG06242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212427_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="52" mass="5510" checksum="689DA29265D468E5" modified="2013-07-24" version="1">MASADANESAAEAEDQDAEICIAQSRPGRTVFSESGNPDGWIGTDLVVEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM2</accession>
    <name>R4VUM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar nucleotidyltransferase ( glucose-1-phosphate thymidylyltransferase ) 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445814.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04855"/>
    <dbReference type="EnsemblBacteria" id="AGN00920">
        <property type="protein sequence ID" value="AGN00920"/>
        <property type="gene ID" value="L593_04855"/>
    </dbReference>
    <dbReference type="GeneID" id="16181121"/>
    <dbReference type="KEGG" id="sali:L593_04855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.992"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="43232" checksum="E7C965DB96E84687" modified="2013-07-24" version="1">MDAVIVAAGKGTRMRPLTDTRPKPLLPVGTTTLLERAMAQCAPHVERYVLVVGYRGEQIRETVGDEFDGKPVAYVEQRERKGTAHAVGQAADVVDDRFLVLNGDLVLDDALFEALAATDGHALTVTTVPNPSQYGVVDVDASASGDGAHADLEVTGIVEKPEDPPSDLGNVGVYAFEPSVFDAIDRTSLSPRGEYEITDSIDLLLEDDEAIAAVEYDGTWLDVGRPWELLDANESVLGQLDSADAALDGTVEEGATLHGPVVVEDGARVRSGAYVEGPVVIRSGADVGPNAYVRGASVIGPDVRIGNGVEVKNSVLLEDAHAAHLSYVGDSVLGAHSNFGAGTVVANLRHDDANVRMRVKGEAVDTGRRKLGVVLGDEVKTGIDTSLNAGVVLGTGAATEPGETVTRDRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUR5</accession>
    <name>R4VUR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445864.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05105"/>
    <dbReference type="EnsemblBacteria" id="AGN00970">
        <property type="protein sequence ID" value="AGN00970"/>
        <property type="gene ID" value="L593_05105"/>
    </dbReference>
    <dbReference type="GeneID" id="16181225"/>
    <dbReference type="KEGG" id="sali:L593_05105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1042"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="224"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="497"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="755" mass="83075" checksum="702D5DFD5C06C63E" modified="2013-07-24" version="1">MRLTVKPLKQKDAGRGLAAIDRLAMDELDLENGDYVLLEGPGDGKAVARVWPGYPEDRGKDVVRVDGRIRKQAGVSVDDRVDLEPADVQPADSVTVALPQNLRIRGNIGPLVRDKLSGRAVAEGQTVPFPLSFGPLSDSSQAVPVKVAETQPTGTVVITDSTEVVVSETPAEQLTETGADAGDGVPDVTYEDIGGLDDELEQVREMIELPMRHPELFRQLGIDPPKGVLLHGPPGTGKTLMARAVASEIDAHFETISGPEIMSKYYGESEEQLRDIFEEAEENEPAIVFIDELDSIAPKRGEAQGDVERRVVAQLLSLMDGLEERGQVTVIAATNRVDDIDPALRRGGRFDREIEVGVPDREGRREILQVHTRGMPLADGIDLDEYAESTHGFVGADLESLTKEAAMNALRRIRPEIDLEEEEIDAEVLDSLQVTERDLREAQKGIEPSALREVFVEVPDITWNDVGGLEDTKERLRETIQWPLEYPEVFEELDMQAAKGVLMYGPPGTGKTLLAKAVANEAQSNFISVKGPELLNKFVGESEKGVREVFSKARENAPTVVFFDEIDSIAGERGQSAGDSQVGERVVSQLLTELDGVEAMEDVVVIATTNRPDLIDNALLRPGRLDRHVHVPVPDEEARRKIFEVHTRNKPIADDVDLNWLARETEGYVGADVEAVAREAAMAASREFVNSVDKSEVAESVGNVRISKEHFEHALEEVNPSVTDDVRERYEEIEQQFDRDEPTEPAGRDAGRTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV03</accession>
    <name>R4VV03_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445000.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00755"/>
    <dbReference type="EnsemblBacteria" id="AGN00106">
        <property type="protein sequence ID" value="AGN00106"/>
        <property type="gene ID" value="L593_00755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181610"/>
    <dbReference type="KEGG" id="sali:L593_00755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.154"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_2_2"/>
    <dbReference type="OrthoDB" id="36379at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="28991" checksum="405E7DF6B8899148" modified="2013-07-24" version="1">MRPGMASSLTRDGRTIVLAHDHGLEHGPTGFSEVPERLDPEQIFELATHDAVGCLAVQKGLAETYLPSYPEVDVLLKCNGTSNLWSGEPYSPQTCSVDYAADLGAAAIGYTVYPGSNHEPRMTTEFSEVQEAAREHDLPVALWSYARGQPIKRTRTEDTVAYAARIGLELGADFTKVKYPSSEESLSHAVDAAADVNVLMSGGSKTNDVEFLETVEGAIDAGVCGLAVGRNVWQREEPEAMLDALERVVYEDESASVAAESLAPAAASGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV86</accession>
    <name>R4VV86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445075.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01140"/>
    <dbReference type="EnsemblBacteria" id="AGN00181">
        <property type="protein sequence ID" value="AGN00181"/>
        <property type="gene ID" value="L593_01140"/>
    </dbReference>
    <dbReference type="GeneID" id="16182382"/>
    <dbReference type="KEGG" id="sali:L593_01140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.232"/>
    <dbReference type="eggNOG" id="arCOG00337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_2"/>
    <dbReference type="OrthoDB" id="77247at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="476" mass="50908" checksum="93340062C5E917FF" modified="2013-07-24" version="1">MNEDHTDESLAFLADVLPEDRVSRSEDVRDSHATDWGTDEGTTPDAVVWPETTEEVSAILSGATEHGIPVTPYAAGTSLEGNPVPAHAGISMDLTRMDVVLEVRPEDHQIDVEPGVMGPAIEDAAGEHGLFFPPLPSSGDISTIGGMIANAASGMQTVKYGEIADWVLELEAVLADGSVITAGSKAVKTSSGYNLRDLLIGSEGTLAVVTRATLELAGRPQQIRGGRALFSTLDDATAAVTDAVQSGVDVAKIELIDAESARMSNAYTGADLPDEPMVFVEFHADHGIEEEIAFCESIFEAHGVERFEIADEARMDDLWRARKDLAFAVRSFDPDLEPLHPGDVTVPISEYGPLIEFAKERAAEENLLVPCFGHAGDGNVHYSVLADPDDPDEVERGEALYAEIVQRAIEVGGTATGEHGVALGKREYLVGEHGEATVEAMRAIKRALDPTDTMNPGKIFPETADGERVLEDELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVS6</accession>
    <name>R4VVS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06790"/>
    <dbReference type="EnsemblBacteria" id="AGN01305">
        <property type="protein sequence ID" value="AGN01305"/>
        <property type="gene ID" value="L593_06790"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1387"/>
    <dbReference type="eggNOG" id="arCOG00230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_3_0_2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="200"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="644" mass="65780" checksum="841FF014D1622ABF" modified="2013-07-24" version="1">MAPVSDRKTFRDLADPDAAAAAIADLPIAPEPPVEAVPLDDAAGRILAERIDAGIDVPGFDRASLDGYALRAGDTAGADEADPVRLEVVGTLHAGEAPGAAEVDDGEAVEVSTGAVMPPGADAMVPIERIDEIASESGAVSDVDVRTAVAPRENVMPAGADLAAGQRALGPGTRLTPREVGLLAALGEESVPVRARPTVGVLSTGAELVPPGEPLDHDSGQIHDVNAASIAAAAREAGADVQRYSTADDDPEALAESLRSAAPACDLLLTSGSTSAGAVDALHSVLEAEGELLLHGVALKPGKPTLVGRLGDCGYVGLPGYPVSAMMVFRTLVAPAIREAAGRPEPERASVEAELLEEARFEPGRRRLLPVGLVEAWSDATTAAGDPDGDRTPLTYPVDRGSGATTSLSRADGLVTVPAETSYVAPGERVTVELFSPAVRPPSLLAIGEDDPGAAAVMDALDRPRYLPDGTAAGVRRLRAGVPDVAVVAGEPRRDAEGPEIAAWEREWGLAVPAGTPEDVATIEDLAGSDLPFANLASGSGLRAALDDRLDAAGIDPATIEGYGVGLRGHESPARRVLTGDAAAGLGLRATAERLDLGFVPFGTQRVRLIGNPDRSDAAGRSALQGVTDRLPELLASISGYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVT4</accession>
    <name>R4VVT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446209.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06840"/>
    <dbReference type="EnsemblBacteria" id="AGN01315">
        <property type="protein sequence ID" value="AGN01315"/>
        <property type="gene ID" value="L593_06840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181577"/>
    <dbReference type="KEGG" id="sali:L593_06840"/>
    <dbReference type="eggNOG" id="arCOG09341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575009_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="17811" checksum="70D5C8B9814E8316" modified="2013-07-24" version="1">MPSSSDREADSPRRADGPEPTPAGRTPSRRTVLHSIGAVGAAGISAGCAALGDGNDGSESTDGGRNHAGASQIHLHNDSDERKRISIEVTRETDSPTTVADRSLSLAPGEVVRLPEGRNVRLGDDLAVLVDVERGPRERYVWTDPTAEQAPLHVFVDGTDNVLFALQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW38</accession>
    <name>R4VW38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445375.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02650"/>
    <dbReference type="EnsemblBacteria" id="AGN00481">
        <property type="protein sequence ID" value="AGN00481"/>
        <property type="gene ID" value="L593_02650"/>
    </dbReference>
    <dbReference type="GeneID" id="16180382"/>
    <dbReference type="KEGG" id="sali:L593_02650"/>
    <dbReference type="eggNOG" id="arCOG02395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_2_2"/>
    <dbReference type="OrthoDB" id="88109at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15666" checksum="32F31791196B25B0" modified="2013-07-24" version="1">MTGTVQEDATQVVQFRLGTERYCVEIDRVSELVHMDELTSIPNADAHVEGVMDLRGQTTTIVDPRVVLDVDEDGPRKRVIVFAGEDGDQGDVGWVVDEVEEVRTIPDDDVDTSVTRDREAVRGIVKDEEFKVLLDPAEING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW45</accession>
    <name>R4VW45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446334.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07475"/>
    <dbReference type="EnsemblBacteria" id="AGN01440">
        <property type="protein sequence ID" value="AGN01440"/>
        <property type="gene ID" value="L593_07475"/>
    </dbReference>
    <dbReference type="GeneID" id="16182139"/>
    <dbReference type="KEGG" id="sali:L593_07475"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_2"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="31537" checksum="D4D9D1FBE7753252" modified="2013-07-24" version="1">MRPAVEHDDVTGSGVYVGGNELRYIRTGEGNGDPVLLLHGGIVDAAHLSWGSAIGPLAADHDVYALDLLGYGLSDAPDVPYTMDRHVETVAGFMDVVGLDSAHLVGTSLGGGIGIQLALEQPEKVEKLVPVSAFGLGTELPNGRRTWLLSQLGFLNRIGLWLASKNRSIATSSLDSVVSDPDALPEELVDAFFRELQRPKAGKAYRSWRKQEVGYGGWNTYYYTRLDDLTCPALFVHGGQDDVFPARWAERAAGIAPQGEVEVFEDAAHWLPRDRPDRLEKLLVAYLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW84</accession>
    <name>R4VW84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation-associated GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446379.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07700"/>
    <dbReference type="EnsemblBacteria" id="AGN01485">
        <property type="protein sequence ID" value="AGN01485"/>
        <property type="gene ID" value="L593_07700"/>
    </dbReference>
    <dbReference type="GeneID" id="16182189"/>
    <dbReference type="KEGG" id="sali:L593_07700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1578"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OrthoDB" id="51913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="2"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="392" mass="42771" checksum="5B5D7D56533D57B9" modified="2013-07-24" version="1">MLTVALAGKPNAGKSTFFEAATRDPVEAANYPFTTIDPNHGVAHVRTRCPCLDREERCGNDTCRDGKRYVPIELLDVAGLVPGAHEGRGLGNQFLDELTNADAVIAVVDAAGATNAEGEPVEVGSYDPVEEVDFVESELVEWLADILDRNWETIERRSRSPDFDVDDALADVLTGFGASEADVAACLRAIEYPDDPKHWDDEDRHALAEHLRRETKPILVAANKMDVAPAEHLERLLDLDRPVVPTTAEGELALRRAAEADLVDYDPGDDDFEIVGDVSDEQRGALEDLQDTVRTYDGTGVQEALNEAIYGMLDRITAYPVEDQSKWTDATGTVLPDAHLLRRGATPRDLAFAVHSDIGEGYLHAVDARSSRDVGDDKELEEGDVVKIVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWH1</accession>
    <name>R4VWH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="3">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445525.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03400"/>
    <dbReference type="EnsemblBacteria" id="AGN00631">
        <property type="protein sequence ID" value="AGN00631"/>
        <property type="gene ID" value="L593_03400"/>
    </dbReference>
    <dbReference type="GeneID" id="16180532"/>
    <dbReference type="KEGG" id="sali:L593_03400"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.688"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OrthoDB" id="35308at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="37484" checksum="861A10F9CBCF455B" modified="2013-07-24" version="1">MTEDGHDEGDHADGDDGGHAHDPEREEFHHDPVGHAEVRAGMTVGELADEYGDAGVGAATLHEAVDIYADMLGDEVTNFVGLAGAMVPTGMRRIVADLIRDGHVDALVTTGANLTHDAIEAIGGKHHHGRSEHPDMTEREHDETLRAEGVDRIYNVYLPQEHFALFESHLRDRVFPPLAQQESVSIADLCAELGRANAEVNDEEDIAEGPGIAAAAWENDVPIYCPAVQDSVLGIQAWIYSQTSGLTLDALGDMTGLNDLAHEADSSGALVVGGGVPKNFVLQTMLVAPDAYDYAVQLTMDPPHTGGLSGATLDEARSWGKLEPAARNVSVYADATITLPLLVAAARERIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWI7</accession>
    <name>R4VWI7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_03475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03475"/>
    <dbReference type="REBASE" id="65272">
        <property type="entry name" value="M.SspHBORF3475P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00646">
        <property type="protein sequence ID" value="AGN00646"/>
        <property type="gene ID" value="L593_03475"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.705"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="42726" checksum="4565B6BAC2FA1B2F" modified="2013-07-24" version="1">MSGGAFGGDGFAASGADGESFSTTHVPLVGDARDLPLPDDSVELVVTSPPYPMIEQWDDLFASLDPAIAEALGLEIGDGEDSFDGDDRADDLDGEAAFDAMHDILYAAWEEVQRVLVPGGIACVNVGDATRTLDRFRVYQNHARIVDAFADLGFDPLPEILWRKPANSAAKFMGSGMVPPNAYATLEHEYVLVFRNGERRSLEPGADRRYEAAYFWEERNEWFSDVWTDVRGERQALGDGPVADDTVRERSAAYPIEIPHRLVNMFSVYGDTVLDPFWGTGTTTTAAMASGRHSVGIERDPVLLRAFEDGVETVPQRSRAIAADRLAAHREFVANRRAAGDELGYDAEFYDVPVRTKQERRLRLYAVESVDRTAAGYRCRHVPAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWQ7</accession>
    <name>R4VWQ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_08650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446569.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08650"/>
    <dbReference type="EnsemblBacteria" id="AGN01675">
        <property type="protein sequence ID" value="AGN01675"/>
        <property type="gene ID" value="L593_08650"/>
    </dbReference>
    <dbReference type="GeneID" id="16182497"/>
    <dbReference type="KEGG" id="sali:L593_08650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1773"/>
    <dbReference type="eggNOG" id="arCOG00861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_5_2"/>
    <dbReference type="OrthoDB" id="20371at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="392" mass="41807" checksum="31C2C991F614E2AA" modified="2013-07-24" version="1">MRVVAKFGGTSLGTGERIERAADTVASAIEEGHEVAVVASAMGSTTDELLDEITFETDEADRAQIVSMGERTSVRMLKAALASRGVDAMFLEPGSELWPVITDAHGELDVEKTEEAAQALAAVMDGVVPVITGFLAETVDGDVTTLGRGGSDTTAVMLGKYMNADEVVIVTDVEGVMTGDPTVVEGARNVGEITVDELRNLSFRGAEVVAPSALAYKDDRMDVRVTHYQHGDLLRGGTRIEGEFRNLVDMREEALACMTVAGRAIRNSPGILQRLSTALGENDINVDAVASGMDSITYYVDQSQAEAAEAVLHDEVVSQEPLSSVTVSDDVAVIRVTGGQLPNRPGVLTDIVNPLGDAHINIRDLITSATSVAIFVDWDDREETLEIVQQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWV2</accession>
    <name>R4VWV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_08750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446589.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08750"/>
    <dbReference type="EnsemblBacteria" id="AGN01695">
        <property type="protein sequence ID" value="AGN01695"/>
        <property type="gene ID" value="L593_08750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181833"/>
    <dbReference type="KEGG" id="sali:L593_08750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1793"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="222"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="495"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="741" mass="82029" checksum="5B1601EFD7D29B2E" modified="2013-07-24" version="1">MNEVQLEVAKAYPNDSGRGIARLDPDTLLHLKLSPGDIIEIEGANSTAAKVWRADRQDWNTDTVRIDGFTRQNADVGIGERVEIRKAEATKADSLVLAPPEEASVQFGSDAAGMVKRQILKRPVVERDIVPVMSSTNHPFMRSPGQAIPLIAVETEPEGVVLVTEDTDVELREEPISGFEKTGGGITYEDIGGLSGEIQRVREMVELPMKHPQIFKKLGIEPPQGVLLHGPPGTGKTLLAKAVANETSASFFSIAGPEIISKYYGESEQQLREIFEDATEESPSIIFIDELDSIAPKREDVTGEVERRVVAQLLTMMDGLESRGQVIVIAATNRVDSVDPALRRPGRFDREIEIGVPDETGREEILQIHTRGMPLSDDVDLGHLADETHGFVGADIESLTKEAAMKALRRYLPEIDLDEEDIPPSLIDRMIVKRDDFRGALAEVEPSAMREVLVELPKVSWDDVGGLEEAKRDIKESVEWPMRDPERFTRMGIEPPKGILLYGPPGTGKTLMAKAVANETNANFISVRGPQLLSKWVGESEKAIRQTFRKARQVAPTVIFFDELDSLAPNRSQEMGSNVSERVVNQLLTELDGLEEMEHVMVIGATNRPDMIDPALIRSGRFDRLVMVGQPDQEGREQILRIHTDDTPLAADVSLREIAERSDGYVGSDLETIAREAAIEALRDDDDAEEVQMKHFRAGMESVRPTITEDLLEYYDSVEEEFRGGSAEPGRGRRGSRIGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWX2</accession>
    <name>R4VWX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445650.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04025"/>
    <dbReference type="EnsemblBacteria" id="AGN00756">
        <property type="protein sequence ID" value="AGN00756"/>
        <property type="gene ID" value="L593_04025"/>
    </dbReference>
    <dbReference type="GeneID" id="16180789"/>
    <dbReference type="KEGG" id="sali:L593_04025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.818"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176006_0_0_2"/>
    <dbReference type="OrthoDB" id="129932at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="10510" checksum="CF91A13629E6F243" modified="2013-07-24" version="1">MSTTTAEERADEAETLSETEYRDRLRELPPSAKLVAKVLESDTPLSQGQLAEESLLPDRTVRYALNRLEDAGLIGSRYSFRDARKQVYYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWX5</accession>
    <name>R4VWX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445655.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04050"/>
    <dbReference type="EnsemblBacteria" id="AGN00761">
        <property type="protein sequence ID" value="AGN00761"/>
        <property type="gene ID" value="L593_04050"/>
    </dbReference>
    <dbReference type="GeneID" id="16180811"/>
    <dbReference type="KEGG" id="sali:L593_04050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.823"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="325" mass="36948" checksum="150DBBC437465170" modified="2013-07-24" version="1">MEYTTLGSTGMEVSRICLGCMSFGTSDWREWVLDEEESREIIERAIDLGINFFDTANMYSLGESERVLGNVLADYDRDEQVVATKGFFQMDEDNPNSGGLSRKAIEQELSNSLERLGMDTIDLYQIHRYDYDTPMEQTLRALDDAVRRGQIRHAGASSMWAHQFADALHTSDRLGLDRFATMQNHYNLVYREEEREMLPLCEREGVGVIPWSPMARGYLTRPHEDIDATTRGETEEHMYEHPYREGGGQEINERVAELAAEKGVTMAQIALSWLLHQDAVDAPIVGTTSVEHLEQAVEALEIDLSESDQAYLEEPYEPVRVSGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX42</accession>
    <name>R4VX42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446684.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09225"/>
    <dbReference type="EnsemblBacteria" id="AGN01790">
        <property type="protein sequence ID" value="AGN01790"/>
        <property type="gene ID" value="L593_09225"/>
    </dbReference>
    <dbReference type="GeneID" id="16182660"/>
    <dbReference type="KEGG" id="sali:L593_09225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1894"/>
    <dbReference type="eggNOG" id="arCOG01623">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054485_0_0_2"/>
    <dbReference type="OrthoDB" id="27323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="3">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="3">
        <location>
            <begin position="124"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="403" mass="42810" checksum="8D12439B773A51D9" modified="2013-07-24" version="1">MATAQGTWAYRDRHGGDFGLTFFRRHGEGVVSSIGLGTYLGDPTDEVDDAYREAIVAALQRGCNVLDTAINYRCQRSERVIGEALAEAADAGAPERDAAGGEADVPETADAAESAPDADVAGSDSGVERESVLVATKGGFLPFDGERPDDPGRYVRETFVEPGIVDPADLAHGAHAIAPAFLDDQLDRSLANLGLDTIDLYYVHNPETQLDVRSREAVYDQLEAAFERLEERRAEGDIRAYGVASWDAFRVPPEHDSHLSLPEVIQRARRAAETAGAQTTGFRAIQLPFNAEMADAFTVAAHEGPEGMQSALHFAQDAGLSVFTSASIGQGELAEGVPEHVAVRVEGDTPAQRAINFARSAPGVTSSLVGASSREHAIENVRAGEFDPLGAEAFDAVFASDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXC7</accession>
    <name>R4VXC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445810.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04835"/>
    <dbReference type="EnsemblBacteria" id="AGN00916">
        <property type="protein sequence ID" value="AGN00916"/>
        <property type="gene ID" value="L593_04835"/>
    </dbReference>
    <dbReference type="GeneID" id="16181050"/>
    <dbReference type="KEGG" id="sali:L593_04835"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="150"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="30412" checksum="711D07164CD84263" modified="2013-07-24" version="1">MYDRILVPVDGSPVGETAAATAIALARRFDAQVHALHVLEVGELPPGVEDDEAGPFETQGQQALDEVSEQAVEAGVEVTTSMITGDADVHRAILGYVDEHDVDCIVMGTHGRQGLGRLILGSVAEQTIRESPVPVMTVHEDTGVPTEFASILVPTDGSDSSNRALEQAVGFAAATGASITGAYVVDDTVVRNGAGMQVAMDALEDAGEETLASLAERAADAGAESIDTTILHGVPYRAIVNYADEEDVDCIVLGTHGRTGVDRYLLGSVTERVIRLSDVPVLTVGGPEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXT3</accession>
    <name>R4VXT3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="L593_05610"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1147"/>
    <dbReference type="eggNOG" id="arCOG08156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109221_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="21217" checksum="C59AD23695232B3D" modified="2013-07-24" version="1">MIRRWTRRRLLASGTAAIGGFAGCLGDDSDAGDGDGSGGENGDGSDGDDRSTTADGGESDESNSDDDVEDSGTDGGSDDLDLREANVTAVAVETEGDGAYRFDVTLLHDDDGEDGYANWWQVETPDGERLGRRELLHAHGTEEFTRSETVTVPAEESCVVVRGHDQTHGYGGQAMLVTIESGATDPRRQGSEPSGFGDAKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU3</accession>
    <name>R4VXU3_9EURY</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02090">
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    </dbReference>
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    <dbReference type="OrthoDB" id="74434at2157"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="255" mass="26598" checksum="9FC273D970D65737" modified="2013-07-24" version="1">MVRVVVPVEVLEGETVSAGLVGLLASADITVLGYHVVPEQTTPEQMQAQFGERARDALADLTDEFQTAGGQADFRLVFTHDREQTVDRVVDEVDAEAVAITGTTGEVTRLLVSLSGDVAADRIVAFVTAVAADRPIEVTLLSATEEETADPGRIEAVADALAEAGVDVVAVTAADDPPLDALVDAVPGHDAVVVGERAPSLSSILLGDFEERVAAATVGPVLVVQRPAAEPGDEDEQEESPHSGERATDREDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY07</accession>
    <name>R4VY07_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">L593_11025</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GeneID" id="16181556"/>
    <dbReference type="KEGG" id="sali:L593_11025"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="308" mass="32989" checksum="6350CE7C02EE8546" modified="2013-07-24" version="1">MRFHLILRKTVADLARPLVLLGYFLVFGGVLFFLAIGFASNDLENVASAPLAQQEAEFYRTFLGISVLWAGSIPLMLLGAIASATSLAKEAEQGTLQILLSKPVRRWEVLLGTFGAIVGFVLFVGIASLLLTGLAIFEFSGTSAAALEEGLFGALPGLLAFVLLIAVFVAALGLTLAVRTGNRLQTGLGSLVVPALYFAFFPVRALAGATYEDYYLYLLDVNYHFGNAFVVLIETVNGGFDAETQAFITTFTGVYDAKQAEAEPENLPESLDLAGHVEPVVSLLAIVLISVGLLAYATYRFQRMDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY22</accession>
    <name>R4VY22_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_06035</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01156">
        <property type="protein sequence ID" value="AGN01156"/>
        <property type="gene ID" value="L593_06035"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06035"/>
    <dbReference type="eggNOG" id="arCOG03937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2784274_0_0_2"/>
    <dbReference type="OrthoDB" id="115405at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="68" mass="7717" checksum="678C6FF8C3C4D84C" modified="2013-07-24" version="1">MDMKQILFLARGLFHTRISLTVIMKITKRLVGRGKITIPAAIREEYGLEDGDFVEVDVAPVDEREENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY86</accession>
    <name>R4VY86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446090.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06235"/>
    <dbReference type="EnsemblBacteria" id="AGN01196">
        <property type="protein sequence ID" value="AGN01196"/>
        <property type="gene ID" value="L593_06235"/>
    </dbReference>
    <dbReference type="GeneID" id="16181653"/>
    <dbReference type="KEGG" id="sali:L593_06235"/>
    <dbReference type="eggNOG" id="arCOG10630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954755_0_0_2"/>
    <dbReference type="OrthoDB" id="97479at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="14783" checksum="A770DC3D4485E22B" modified="2013-07-24" version="1">MVEKGKLPGKYNIVLEDAIDLFDHRVPVEEFEERLEENDLPDELCVVGLSDVFGEDEAVSDLRSSMDRRANSLENRSSLPTIQFAVEGSFQRRQRDYELQVGDELYRLSRIFGPQIDRESSDWLTAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYC1</accession>
    <name>R4VYC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01216">
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    </dbReference>
    <dbReference type="GeneID" id="16181664"/>
    <dbReference type="KEGG" id="sali:L593_06345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1294"/>
    <dbReference type="eggNOG" id="arCOG05219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263218_0_0_2"/>
    <dbReference type="OrthoDB" id="12416at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142006" checksum="DF52D8212F19B8C8" modified="2013-07-24" version="1">MTIADLFERDPTRQLEEVQKINASEQAETDVAEFHQTESAEQVLSELGDTIETHPGEAARFLYIHATFGSGKTHLLKLVGLLTDDQSDYAYLGDRLADQWGGFHALQQSIGASHVDRLVPVFLNLLDRDASKEPPLPFLIFEAIGRELGYPTDPNWLLEWAWTVDMEYDGVWEALQAGEHDRQTFEDVLEERASLRKWLYEAVPALAETDGTDLDSVAGVKDSIERAVAEVDPESFDPDELVSRVQTATEALNDDGSRTELLLGLDEVALFVGDSSHRYREFEETMEALQRGPNPVVVSTGQYSLPITRESLIGEPPTDHWTYKQVELEGADTEIIVRKRWLRKSEDGGDSVETLLSDLSDLSLDTYSSVASMDPDPIESYPFREYDLTLLRAVMQELITQGRSTDREYIQGRALLVLVRSLFTTFDWASREPGALVTWDVLFDLLVEETTYLPLWVQEMIDNTLVPTFDGDEDAWEVRLAKALYLLNQTPAVPATPENLGRLLVDDVTADVEAVVERAESGLQTLVDKQKVLTETNDEGDEVYTLVSEEQESVLSRAQDKAAQISPHQLSAWLETRLRENDSFLRREGTRHETDVGDERLVPLRYEYSILEPVDRAPSPEYDAIQVRVLADEGETVSDQVSTWRDVNDGRDGGEHVLVTMDVASTMLERIQNVIGMGQVLDEETESHEELEREHRTDKRRLEADVTEVLEEATVHTIEGERGQRDSVLETVVAEQVEEVFGSSRRTLSRPLAEVDDAKAMASFFRGSGEWPLSNADAATLGVDTANGAVAETGWCAEFIENYEGQQAVDVETLLQQTRTANGAYRGSPRESIAALLITLATSNEDVVLKQDTDQLSDPAAIGRQVRTKGGLTSLTVRFEPIIPPKKVREFVTTVQGSGPDGDGPDEWLHELAGWADANSASIKRTLKDVSREFDASMDTFESLIEPALTGGELSMSAFGSESLLDDAIEEAETFATARELFESDEGETPLWEQFTEELEVMTSLYPDSSTTDSMQATAASETVPSVSTVESRLDEARSHRVEAVAAQFRRITGTTTDAATPAGACNELMEWLGSNEERVRSILEAAADEFEAATLADLETLFEAVWEGKAVTEATIVDATAVQQVETYERLRQLLDDADGQSLWSQLQDAGDHLRSDHPDSPTTDAVETALDSSRPPTERRVRQLLERAEDPRPPRPDDDDWAALLRITEELRQNHPAAEITDEVTAAVDGNERPDAERVTELLEGARPVLERINRVTERLDELEDGSIVLIEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYQ2</accession>
    <name>R4VYQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447284.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12235"/>
    <dbReference type="EnsemblBacteria" id="AGN02390">
        <property type="protein sequence ID" value="AGN02390"/>
        <property type="gene ID" value="L593_12235"/>
    </dbReference>
    <dbReference type="GeneID" id="16180585"/>
    <dbReference type="KEGG" id="sali:L593_12235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2516"/>
    <dbReference type="eggNOG" id="arCOG06948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820440_0_0_2"/>
    <dbReference type="OrthoDB" id="35297at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="37788" checksum="A0380E1B958AD5FC" modified="2013-07-24" version="1">MELERGPLTILLNALFDAGEDEIAVRHPADEVGELLRIELGDPGSSTVHFPADHDDYANARHAVEREYGSGVSDELPDPRSYCNGLMAGGLVDPANSDDIEAFLDRYGSPDLTAGHKPVVAGFDTNLLPWRIADVLELYPGPEATVNGFALATGVRDELDWDHKRSDTGRIESAFGSEFSALWNQPAGSRREGRLGENYYRLLRDHRYADEVTTDRGDEDIVQGYDAYQDDNRKEVLLFSNDRDFIERARSHRVLAQRVEVPRSLPEMAEASWDDICNALYVLTVLFGVLELPKVTLYGVWQGKGGQAWQREQLRVDCRSPKVEAPVERDLEILSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYQ9</accession>
    <name>R4VYQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dmt(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446270.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07145"/>
    <dbReference type="EnsemblBacteria" id="AGN01376">
        <property type="protein sequence ID" value="AGN01376"/>
        <property type="gene ID" value="L593_07145"/>
    </dbReference>
    <dbReference type="GeneID" id="16182016"/>
    <dbReference type="KEGG" id="sali:L593_07145"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_2"/>
    <dbReference type="OrthoDB" id="47457at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="304" mass="31559" checksum="E2912733469BB468" modified="2013-07-24" version="1">MSRVRTLLLFALVTLIFGTAFPAVKAGLAYFPPLLFASIRNYVAGLLLLAYVGATATYRVPVSRADWTAVIAGGAFLIGGVGFGFVGQQYITSGVAAVIFSLSPIVIAVLAWVLLPAERLTGRDYVGVVLGFLGVAIVVRPDPAALLDPELVGKLLVFTGVVVIALGTVLVRRSEPALPVPALTGWAMLLGATLQFCAALAVGESIAAIDVTPAALLTIGYLGLFVGAIGFVSYLTLMGTVGALNANLTTYLTPVVALVVGWAALGEDVAVLTLLGFGVIAAGFAVLQRRELYAELASYRGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ45</accession>
    <name>R4VZ45_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5658 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447434.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13005"/>
    <dbReference type="EnsemblBacteria" id="AGN02540">
        <property type="protein sequence ID" value="AGN02540"/>
        <property type="gene ID" value="L593_13005"/>
    </dbReference>
    <dbReference type="GeneID" id="16180321"/>
    <dbReference type="KEGG" id="sali:L593_13005"/>
    <dbReference type="eggNOG" id="arCOG08153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1965660_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043717">
        <property type="entry name" value="DUF5658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18902">
        <property type="entry name" value="DUF5658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5658" evidence="2">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="12673" checksum="70CA12457352A125" modified="2013-07-24" version="1">MALLEPLPAPAGRSSTQKGESLTAHFGAILARNERWLWAVAVLALLADVVTTLVGLQTGLAEGNPVVAGALADAGLLGFFGVKVGVLALAVGGRIAAPGFRVAIPLGIAVPWLAAAGTNALLLFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZA7</accession>
    <name>R4VZA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08230"/>
    <dbReference type="EnsemblBacteria" id="AGN01591">
        <property type="protein sequence ID" value="AGN01591"/>
        <property type="gene ID" value="L593_08230"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08230"/>
    <dbReference type="HOGENOM" id="CLU_1912426_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="132" mass="13826" checksum="94EF336C0F4A6BDE" modified="2013-07-24" version="1">MAGGIRRRRLLGGVATAVGVAVAGCSSGGSDDDSSADDTVASGGAETSNADGGTDSDGDGEGPSEEPPAAYIVDLKDASGQNIGTRNTEQTWDDHRFDRAALYENCVSEWHQAAVYDQVIQELENNNQEKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZJ7</accession>
    <name>R4VZJ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447584.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13755"/>
    <dbReference type="EnsemblBacteria" id="AGN02690">
        <property type="protein sequence ID" value="AGN02690"/>
        <property type="gene ID" value="L593_13755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181566"/>
    <dbReference type="KEGG" id="sali:L593_13755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2813"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OrthoDB" id="58398at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="24669" checksum="0E28E9E14E54E1AF" modified="2013-07-24" version="1">MTPPLALDIDGTLTDPEHDRIDPRLFDPRLFDPLLEWPEPIVLATGKAFPYPVALCHYLDIPIRVVAENGGVAFADGVTEILGDGEASRAVAQAYQDAGHSLGWGGVEPLNRWRETEVAVQIDQPEAPLRELAAEHGLEVVDSGYAYHVKSPDVDKGKGLEIVAAAIGVEPEDFVAIGDSENDVETFELVDRSFAVANADDAARSAADELLDDAHADGTLAVLERLREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW6</accession>
    <name>R4VZW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09080"/>
    <dbReference type="EnsemblBacteria" id="AGN01761">
        <property type="protein sequence ID" value="AGN01761"/>
        <property type="gene ID" value="L593_09080"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1862"/>
    <dbReference type="eggNOG" id="arCOG02981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745500_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="172" mass="17993" checksum="774B0CCAEAEB3CB2" modified="2013-07-24" version="1">MSTPDDDAGARTRDSGIEIRSPTAILEDERAIEGLPIRLVIALLVGVAALSVMMTMIDDVNGIGKTELDAEPAPDTFDLSSDAKRDVTITVVDDDGDAVSGATVVLQGESAQLEGGARHAESGNGGDVTFDDVEPTLSDNQDQGTLSIDVQPPTDGNFQDERPNTEILVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W058</accession>
    <name>R4W058_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_09605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09605"/>
    <dbReference type="EnsemblBacteria" id="AGN01866">
        <property type="protein sequence ID" value="AGN01866"/>
        <property type="gene ID" value="L593_09605"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1977"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="130"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="7">
        <location>
            <begin position="432"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="524" mass="57430" checksum="AE85A3AD84C6FEA7" modified="2013-07-24" version="1">MNENDASAMDESEDAEHADGSGSEGEADDPLGGAGDGDGRAGSDAVGDGSDADREESGLAAATADLPADGAAPGLDDEGGGLFDELLAGERIFEDKEVLRPSYTPNRLPHRGSQINEIATVLVSALRGDTPSNILVYGKTGTGKTASAKYVSQELERSASEYDVDCEVEYINCEVTDTQYRVLAQLGNEFIEDNLERAEDDISELTAIVDAVNVERANELGFEDLAAVRDRIEELRAYTETAEEIPMTGWPTDRVYQAFFEAIDLYERVLVFMFDEIDKLVEKSGDDTLYNLSRINSGLDRSKVSIIGISNDLKFTDFLDPRVKSSLGEEEIVFPPYDAEQISDILDQRAEIAYRQDALEQDVIPLCSAFAAQEHGDARRALDLLRCAGEFAERDGEDCVGAEHVRRAQDKIELDRIVEAVRTLPTQSKLVLLSIIELDEDGESRVTTGEVYNVYRTLAEEAGLDPLTQRRATDLISELDMLGIVNAVVVSKGRYGRTKEISVSVPTDRTREVIEQDARLGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W061</accession>
    <name>R4W061_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongator protein 3/MiaB/NifB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447794.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14830"/>
    <dbReference type="EnsemblBacteria" id="AGN02900">
        <property type="protein sequence ID" value="AGN02900"/>
        <property type="gene ID" value="L593_14830"/>
    </dbReference>
    <dbReference type="GeneID" id="16181491"/>
    <dbReference type="KEGG" id="sali:L593_14830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3029"/>
    <dbReference type="eggNOG" id="arCOG01360">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060488_0_0_2"/>
    <dbReference type="OrthoDB" id="29724at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005909">
        <property type="entry name" value="RaSEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004954">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01210">
        <property type="entry name" value="TIGR01210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="8">
        <location>
            <begin position="55"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="369" mass="41015" checksum="DDA57FE69050FE80" modified="2013-07-24" version="1">MSEPSPEVYEEGRGMDAHNQVMRSIRAEKEAEYDPREPTRVWIDEDNTPNGVRESLTIVLNTGGCRWARAGGCTMCGYVAESVEGGEVSHDALMAQVDSVLEHEEANADGLCDLVKIYTSGSFLDEREVSAESRRAIADTFADRERIVVESLPDFVDRETLADFTDRGLDTDVAIGLETTSDRIRRDCVNKYFAFSDFEEACAEARAADEAAGTDDSDPDVGVKAYLLMKPPFLSEQEAIDDMISSVYDCAETEGCHTVSMNPCNVQRYTMVDELYFQGGYRPPWLWSVADVLESTADADAIVISDPVGHGSDRGPHNCKECDDRVQRAIKDFDLRQDPSVFDQIECECEATWEAVCEREAGYNLPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0D0</accession>
    <name>R4W0D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446845.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10030"/>
    <dbReference type="EnsemblBacteria" id="AGN01951">
        <property type="protein sequence ID" value="AGN01951"/>
        <property type="gene ID" value="L593_10030"/>
    </dbReference>
    <dbReference type="GeneID" id="16182833"/>
    <dbReference type="KEGG" id="sali:L593_10030"/>
    <dbReference type="eggNOG" id="arCOG02416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1976629_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13495" checksum="60F6471C8BAB9D78" modified="2013-07-24" version="1">MSLSPDRKLDALGAVLVVLVIFGVGLAVFGAIEVSEDDGEATPETNFSVERINDSHVRLVHAGGDVVRGDELVLTIDGRDRVPVQPFPPSVSEGDGTIVRVSEGHTLRVYWTGGRGTQERLDSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0K5</accession>
    <name>R4W0K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446955.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02061">
        <property type="protein sequence ID" value="AGN02061"/>
        <property type="gene ID" value="L593_10580"/>
    </dbReference>
    <dbReference type="GeneID" id="16182538"/>
    <dbReference type="KEGG" id="sali:L593_10580"/>
    <dbReference type="eggNOG" id="arCOG04576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196451_0_0_2"/>
    <dbReference type="OrthoDB" id="123891at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="7349" checksum="B4996261953D4D45" modified="2013-07-24" version="1">MGTRLRTPEDRTCERCGREETWDEDDGVWRIVREDGERRVGDPYCIHEWDITGEFSPIEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1R4</accession>
    <name>R4W1R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_13210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447475.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13210"/>
    <dbReference type="EnsemblBacteria" id="AGN02581">
        <property type="protein sequence ID" value="AGN02581"/>
        <property type="gene ID" value="L593_13210"/>
    </dbReference>
    <dbReference type="GeneID" id="16180467"/>
    <dbReference type="KEGG" id="sali:L593_13210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2703"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OrthoDB" id="58511at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="31790" checksum="E0EFB8720C7E0F5C" modified="2013-07-24" version="1">MIPLQGLGPVERFLEDNTDLALGTIDTLSSLLIFVGVLVGLYVIGRATVLPIARRLFARRGLDEHASKPLLKVVWFVVLFAAIAIAFGAAGYGNFLSSLAVIAAAATLAVGFAMQDVIKNFVSGIFIFSEKPFRIGDWIEWGDHSGVVEDISLRVTRVRTFDNELLTVANSELTNGVLKNPVAKDKLRLQFTFGIGYGDDVDAATEIVVEEAEAHDGIMDDPAPSVRLTELGDSYVGLTSRIWIENPSRADFVGIRGEYVQSVKERFDEEGIDIPYPTRTLDGVVEVGEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1S2</accession>
    <name>R4W1S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447485.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13260"/>
    <dbReference type="EnsemblBacteria" id="AGN02591">
        <property type="protein sequence ID" value="AGN02591"/>
        <property type="gene ID" value="L593_13260"/>
    </dbReference>
    <dbReference type="GeneID" id="16180307"/>
    <dbReference type="KEGG" id="sali:L593_13260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2713"/>
    <dbReference type="eggNOG" id="arCOG04688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327337_0_0_2"/>
    <dbReference type="OrthoDB" id="117149at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045490">
        <property type="entry name" value="DUF6432"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20024">
        <property type="entry name" value="DUF6432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11062" checksum="D638637E5B311E1F" modified="2013-07-24" version="1">MPVAQGYRDRGDVELAVLEALVDRHEEGMTVFELRTHVATDIDSIEDALASLKEDDLIVVENGPEAPGSATIKPADRVVPSGEEVDDESFVEWLRDRLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2A2</accession>
    <name>R4W2A2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447680.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14235"/>
    <dbReference type="EnsemblBacteria" id="AGN02786">
        <property type="protein sequence ID" value="AGN02786"/>
        <property type="gene ID" value="L593_14235"/>
    </dbReference>
    <dbReference type="GeneID" id="16181156"/>
    <dbReference type="KEGG" id="sali:L593_14235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2914"/>
    <dbReference type="eggNOG" id="arCOG04767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_2"/>
    <dbReference type="OrthoDB" id="81003at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="18735" checksum="6FFFDC5EBA61BC97" modified="2013-07-24" version="1">MGDTTAILHTNRGDIEVELYEDKVPNTVENFVGLATGQKEWEDPETGETIDGEPYYEDVPFHRVIADFMIQTGDRTGTGRGGPGYTFDDEFHDDLSHDGPGVLSMANSGPNTNGSQFFITLAAQPHLDGKHAVFGEVIDGMDVVEEIGNLPTDRSDEPQEEATLESVTVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2N4</accession>
    <name>R4W2N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00460"/>
    <dbReference type="EnsemblBacteria" id="AGN00047">
        <property type="protein sequence ID" value="AGN00047"/>
        <property type="gene ID" value="L593_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00460"/>
    <dbReference type="HOGENOM" id="CLU_1029032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="270" mass="27044" checksum="927A92027A95E940" modified="2013-07-24" version="1">MESRRECMSGNGDAVGGDAGQHRVPEPLRERVDELFVAERGYEPASFQEALSVVVDLASAATAPSDDASAASAGPTSGPSNGTTDPASSTDADGTDSPVTGAGGSGGEASSAESSSEAGTTDLSEATIESSEFESVSFDDYVDGLDESRRDPSPGVESMLDTAHADGVVRELAAEVLDEMTSEAFDELEHGVDQGVGAGVTDGMGATQTTDSAGTAPSGSQGDGVPDSLTADPESDCAICGRAHPVSVLQTTIRESEGGSVALVCPSCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2U6</accession>
    <name>R4W2U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445051.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01010"/>
    <dbReference type="EnsemblBacteria" id="AGN00157">
        <property type="protein sequence ID" value="AGN00157"/>
        <property type="gene ID" value="L593_01010"/>
    </dbReference>
    <dbReference type="GeneID" id="16181691"/>
    <dbReference type="KEGG" id="sali:L593_01010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.207"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="37481" checksum="A61A903328ADD89A" modified="2013-07-24" version="1">MRAAVLEAHGEPLSVQEVDYPEPGPEQVVVETEACGICRSDWHAWRGDWEWMGISPSPGQILGHEPAGVVSEVGDEIESLSEGDRVTVPFHLGDGTCPYCRNGHSNVCETSVPLGFIGAAQGAYAEAFPVRKADFNVTKLPDSVDFTEMAALGCRFMTAYHGLTDRAGLRPGDTVAIHGCGGVGLSAVHIADALGAVPIAVDVQESKLDRARELGAAATINGAEVDDVPGEVFRANDGNGADVSVDALGIEETCGNAVRSLGKTGTHVQIGLSEGDTGGQLSVPVDQMTLQEIDFHGSYGMPLVRYDELFTLIERCTLQPEKIVGETLSLEDAPETLASMDDYETIGIPVITEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W326</accession>
    <name>R4W326_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_01595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445166.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01595"/>
    <dbReference type="EnsemblBacteria" id="AGN00272">
        <property type="protein sequence ID" value="AGN00272"/>
        <property type="gene ID" value="L593_01595"/>
    </dbReference>
    <dbReference type="GeneID" id="16181355"/>
    <dbReference type="KEGG" id="sali:L593_01595"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="325" mass="34784" checksum="54BE3D6346988576" modified="2013-07-24" version="1">MPAIETNGLSKTYGESVTALQDLDLTVEYGDVYGFLGPNGAGKSTTINLLLDFIHPTDGSAEVLGYDTRTDSLQIRENIGILPEGAEPYDRLTGREHVEFAMESKDVDGDVDAVLDRVGLSGEDADRRAGGYSKGMAQRLGLGMALVGDPDLLILDEPSTGLDPAGMAEMRDLIREEAADGTAVFFSSHILDEVEEVCDRVAILNEGRLVADDDLDELREEFTGECDVTLDVAEPPAGGVDLAPVDGVVETAVEDDAIIVTCEHPRVKADVVRYVDDHHDVTDVISEETSLESMFERYTNGSVEESDSAADGATSEAAEPAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3B1</accession>
    <name>R4W3B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445316.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02355"/>
    <dbReference type="EnsemblBacteria" id="AGN00422">
        <property type="protein sequence ID" value="AGN00422"/>
        <property type="gene ID" value="L593_02355"/>
    </dbReference>
    <dbReference type="GeneID" id="16180179"/>
    <dbReference type="KEGG" id="sali:L593_02355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.478"/>
    <dbReference type="eggNOG" id="arCOG04781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943817_0_0_2"/>
    <dbReference type="OrthoDB" id="112454at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043825">
        <property type="entry name" value="DUF5802"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19118">
        <property type="entry name" value="DUF5802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="13405" checksum="C32195EE112B1A7B" modified="2013-07-24" version="1">MFEEFSSGYYLGRLYVQPTDGDAAVIDRDQHEHVNRELYATGEGLERLDAPLVMKVHERHVPVHGEDGVPRDTLFLPESVVDATRIQNPPTLTEVLLAKADRAKQLLRITGRGQDRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3F7</accession>
    <name>R4W3F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445396.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02755"/>
    <dbReference type="EnsemblBacteria" id="AGN00502">
        <property type="protein sequence ID" value="AGN00502"/>
        <property type="gene ID" value="L593_02755"/>
    </dbReference>
    <dbReference type="GeneID" id="16180324"/>
    <dbReference type="KEGG" id="sali:L593_02755"/>
    <dbReference type="eggNOG" id="arCOG03860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060475_0_0_2"/>
    <dbReference type="OrthoDB" id="56787at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="306" mass="34017" checksum="CC08B4462329C315" modified="2013-07-24" version="1">MAPDPPAHAVFGLLSDATRVEILSTIARTPGERGPPGGTATLSFSEIYDRVDVEGTSKLSYHLGELEGVYLRNSPEGYSLTHGGEQIVRLLLSENYANTPDFDPIEIESPCAFCGAEPLRASKHNQFLGIDCPTCDRMAIAYEATPAQVRSRSSEELLESFRDRFVSHYRQVRDGLCPSCAGPLEGSVHPTAEMEDADTGDRDLLIVMDRCEECLRAYNAPLQLALGYHPASVSFHWERGVDVTSIPPWELFRRVYAGEWTADVAESGYEVVLRHDRDALRLDLDEDLAVSRTERVRGRTVDEERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3G0</accession>
    <name>R4W3G0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="8">ATP-PRT</shortName>
            <shortName evidence="8">ATP-PRTase</shortName>
            <ecNumber evidence="3 8">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisG</name>
        <name evidence="11" type="ORF">L593_02780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3 8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445401.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02780"/>
    <dbReference type="EnsemblBacteria" id="AGN00507">
        <property type="protein sequence ID" value="AGN00507"/>
        <property type="gene ID" value="L593_02780"/>
    </dbReference>
    <dbReference type="GeneID" id="16180314"/>
    <dbReference type="KEGG" id="sali:L593_02780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.563"/>
    <dbReference type="eggNOG" id="arCOG02208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_0_2"/>
    <dbReference type="OrthoDB" id="56745at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="9">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="10">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="290" mass="31265" checksum="2D965DA53DD7B70B" modified="2013-07-24" version="1">MRIAVPNKGRLHEPTIELLERAGLHLRDGADRKLYADTVDPDVTVLFARAADIPEYVADGAAEVGITGRDQIAEADPGNVTDLLDLEFGECRLVLAAPEDGEITEPGDVAGGKVATEFPTITRNYLEEAGIDAKVVEVTGATELTPHAGMADAIVDITSTGTTLQVNRLAVIDEVLQSSVRLFAREDVIDQNKVEQIRTAMESVLDAEGKRYLMMNVPRGQLEAVREQIPGLGGPTVMDVADREEPASDEEDMLAVHVVVDERDVFETITNLKAAGASGILVTEIERLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3M8</accession>
    <name>R4W3M8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_03380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445521.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03380"/>
    <dbReference type="EnsemblBacteria" id="AGN00627">
        <property type="protein sequence ID" value="AGN00627"/>
        <property type="gene ID" value="L593_03380"/>
    </dbReference>
    <dbReference type="GeneID" id="16182432"/>
    <dbReference type="KEGG" id="sali:L593_03380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.684"/>
    <dbReference type="eggNOG" id="arCOG01431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OrthoDB" id="82750at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="328"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="403" mass="43557" checksum="51A4E376DF397DF5" modified="2013-07-24" version="1">MLSLSDVEAARERVAETARDTPLKQSHTFSAMTGADVNLKLENFQRTGAFKIRGATNRIKTLTPEQQAAGVVTASAGNHAQGVALAASRLGVDAKIVMPEYAPISKLQATRSYGATVELHGLDYAEAAERAHEIEQEEDRTYVEAFDDEQIMAGQGTIGLEILEQCPDVETVVVSVGGGGLISGVATAIKERRPEVRVIGVQAEGASSLAQSLDKGEIYERDSVDTMADGIATRRVGDLTFDVIEERVDEVVTVSDPEIAMAVLYLLERSKTLVEGAGAAPLAAILQESFRFAEDETIVPLLSGGNLDLNTLTTVIVRGLVETGRYVKLQTVLKDRPGALDDLISILSAQKANIYRIQHDRSSRDIDMNAAEVELDLETRGHEHVAELLDAMEDRGYEVELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3P5</accession>
    <name>R4W3P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445551.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03530"/>
    <dbReference type="EnsemblBacteria" id="AGN00657">
        <property type="protein sequence ID" value="AGN00657"/>
        <property type="gene ID" value="L593_03530"/>
    </dbReference>
    <dbReference type="GeneID" id="16182747"/>
    <dbReference type="KEGG" id="sali:L593_03530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.716"/>
    <dbReference type="eggNOG" id="arCOG01907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_2"/>
    <dbReference type="OrthoDB" id="90481at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="24648" checksum="1E3CA9B363674348" modified="2013-07-24" version="1">MNIELTHQPSYTHVVADLEMGETILAEPGAMVSHTSTVAVDTTTSRDGLLSSAKSMLGGESAFANEFTAEDGPGTVTLAPPTPGDVKHFQLAEETLYAVDGSYLASDPAIDIDSELGGLKTMLGGAGLTPLALKGTGDVLIEAFGGIESVELSADETYTIDNEHLVAWEGSVDFDVRRVGGLKSTILSGEGLVLDFSGPGRVWYQTRGLDSFIAAIGENVTAEGQDGQGSPDMDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3V8</accession>
    <name>R4W3V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal-transducing histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03980</name>
    </gene>
    <organism evidence="3 4">
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
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        <location>
            <begin position="13"/>
            <end position="70"/>
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    <feature type="domain" description="Histidine kinase" evidence="1">
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            <begin position="140"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="37118" checksum="14BDB3B6E3E1A629" modified="2013-07-24" version="1">MTAQRETAANALDAERFRHLFEHVQDAIVDFEFVDDEPIIREVNDAFVDLFGYESPAIIGESLNDLIVPSWLAGESDEFDERTASGEHNHAVVDRQTKNGVKTVLYRGVPYADGDRGLAIYTDLTDEIRQERQLAVLNRVLRHNLRNEVNVLAGNAEELLETADSPAIEAAAETIRDSALTLSRLGDEARDIERVLDADPDLEPTELGPVVAAARDAVPLTERATVAVDVADAPPALTGGHLDRAIAALLDNAVRHSEAPTPCVAISASASADRVGLTVADDGPGLPERERRLLTGDLELTPLDHGNGLGLWLVRWIVTAYGGSVEYTDRPNGGSAITLWVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4S5</accession>
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    </gene>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="18"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="51"/>
            <end position="76"/>
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            <end position="115"/>
        </location>
    </feature>
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        <location>
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            <end position="155"/>
        </location>
    </feature>
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        <location>
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            <end position="190"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="237"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="39051" checksum="3A19A64FF183C636" modified="2013-07-24" version="1">MEASDVRRTLSRLRVEQVLGAILGLLLVFLVVDLFRQLLTGALDVSTLRRYVWQGIVVGLIYGLAGIGLSMTYSILRFANFSHGDLLTTGAFSGWASAYVIAGFGAYGLGDLLLVRPNNDPAPGQIGMAIDQEPIAILGGIAFAAVVTVLIALAADRLVYRRLRNESAIALLIASVGVAFVLRYLIAFVFTTSNRSVPASAPEETIDLGFVSTTVDLHELTLVTSAVVLMVAVHLMLQYTKLGKSMRAMADNRDLAKITGIPTERVVLATWVIGAALAGVAGYLIVLNTGTITYTRGWTLLLPIFAGVILGGIGSIYGAILGGLVIGIVDQVAIIWVPNRLTTAAAFLLMILILIFRPQGLLGGVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5R2</accession>
    <name>R4W5R2_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_09735</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01892">
        <property type="protein sequence ID" value="AGN01892"/>
        <property type="gene ID" value="L593_09735"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="118473at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="10136" checksum="1073CC0F0656B87A" modified="2013-07-24" version="1">MPGRVDIEIENRHDRWRYVCPMGHRSWEPTNHHFWCKLCANHEDDDGTFDALLDRKTDELLQREEVRLLTEAGPYDGDVDRRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T7</accession>
    <name>R4W5T7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">L593_09935</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09935"/>
    <dbReference type="EnsemblBacteria" id="AGN01932">
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        <property type="gene ID" value="L593_09935"/>
    </dbReference>
    <dbReference type="GeneID" id="16180359"/>
    <dbReference type="KEGG" id="sali:L593_09935"/>
    <dbReference type="eggNOG" id="arCOG02170">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="27428" checksum="486EE29AB3C96ED9" modified="2013-07-24" version="1">MDRRALRSAAVAITAVLAFVLAAAAFGPTVPDAKPADGGSLPDDPEDPNAGASGGGVESADGGPSVDCPGCSVLDLRSHVATLLPTGDPRLLLGVLGIAVLGLTAVGLRSGERDRSEDVVATGDDVPGIRHTARSAGRADRSLDAPPVNDVYRAWRELADGVDLHDVDSTSPRQVARRAIGAGYPADAVASLTELFECVRYGDASATPERERRARAAADRIDAAEPDEQGQAESTEQVPPESKDQTPAGSTSDATATTRSRSNGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y4</accession>
    <name>R4W5Y4_9EURY</name>
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            <fullName evidence="2">Macrolide-efflux protein</fullName>
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        <name evidence="2" type="ORF">L593_00515</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00515"/>
    <dbReference type="EnsemblBacteria" id="AGN00058">
        <property type="protein sequence ID" value="AGN00058"/>
        <property type="gene ID" value="L593_00515"/>
    </dbReference>
    <dbReference type="GeneID" id="16181775"/>
    <dbReference type="KEGG" id="sali:L593_00515"/>
    <dbReference type="eggNOG" id="arCOG00135">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_1_2"/>
    <dbReference type="OrthoDB" id="79672at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="437" mass="44288" checksum="1A7826B6BE2973C9" modified="2013-07-24" version="1">MHSDVDGESGLRARLLADETEALLGNAGFQRLYAGRMVSRIGDKLYVVAAMWLVFELTGSTLYTGFAGFLSKAPQALGFLAGPLVDRARLGRLLAVTEATQAVIVGSVPLAWWMGYLSVGHVLVVVTLLTVLRRVTAPAEQAALPRLVPEALLARANSIDSTTKHALGATAEALSGAIIAILGAVSLFAVNAATFVCSAVTFGRLDVPDASSTGEAPSAREYLDDVRSGFALVRHSVVGHMVVAAALTGVFTGMATAVLPAFAGTIGSDAETFGLLVGATTAGTLVGSLLAGRLHEVDFGQITVVGFLFAAAGRAAAAVVGWQPAVLLFYGAAAIPVGVYNVLVSAAIQTGVPNELLGRVSSTTGSLVAVVGPLGLLAGGVLGGVLDSATVVALSAVGYLCISAYWLVVPSLREFPAVVDVEAGGFGRGRTGGSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W605</accession>
    <name>R4W605_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monovalent cation/H+ antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444987.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00690"/>
    <dbReference type="EnsemblBacteria" id="AGN00093">
        <property type="protein sequence ID" value="AGN00093"/>
        <property type="gene ID" value="L593_00690"/>
    </dbReference>
    <dbReference type="GeneID" id="16180108"/>
    <dbReference type="KEGG" id="sali:L593_00690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.140"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="135"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="541" mass="54773" checksum="35CB76C74BF88475" modified="2013-07-24" version="1">MSDVTLAPVLLIALPIVAAALTLVVGLRWPTAGWSMALLAMLGEAGLAAWLANAVYGEQGRIVHELGAYGRPGPENFAVGIELVADALTGVMVGLIAVVALAVLAVTRRAGPRGTPFYAAYLLLIAGLMGVVLTGDVFNLFVFLEITGIATYTLVASDRSAPAAVASLKYLIVGTTGASLYLLGVGYLLMATGTLNMADLSATLAGEPSFVDGPLYTDTLVLASYAFIATGLFVKSAIFPLHTWQPGAYAEAPDGVTVLISALASTIGAYAFLRITLTVFTPAFFAATPIVATTIVTLASISVVAGSALAVMQSRVKRVFAYSSVSQFGLIVTAVGIAVHPDAGASASEAALVGAVIHLVGHAIVKGGLFAAAMGLARDAGARRVRDLAGLGRESPVLSASLAVLGFTLVGVPPAVGFLGKWYIAVGAIDAGIWPVAAVILLSTVFTLAYVARIVEQLYFTPSPSAGDVGVDVDADAPSDESGGRAVAADGGAVEDGTLDGVPFGIVAVAVAAAIMAVLLGFAGPELSDAIDPFVTEVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W611</accession>
    <name>R4W611_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444997.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00740"/>
    <dbReference type="EnsemblBacteria" id="AGN00103">
        <property type="protein sequence ID" value="AGN00103"/>
        <property type="gene ID" value="L593_00740"/>
    </dbReference>
    <dbReference type="GeneID" id="16180523"/>
    <dbReference type="KEGG" id="sali:L593_00740"/>
    <dbReference type="eggNOG" id="arCOG03687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1912282_0_0_2"/>
    <dbReference type="OrthoDB" id="92473at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13645" checksum="B64C4FAEAA9E9CB6" modified="2013-07-24" version="1">MAKTAHTVSTEGFSSENHVRDFELTIDATGESGPDTLEVLIADYASCYVPALRVASEQRGADDLGEVAIDVTGELNDDDKLESIHFDVEVDADLDDDTATAIVERANELCKVHDALKESLYAEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W627</accession>
    <name>R4W627_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_00865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445022.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_00865"/>
    <dbReference type="EnsemblBacteria" id="AGN00128">
        <property type="protein sequence ID" value="AGN00128"/>
        <property type="gene ID" value="L593_00865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182102"/>
    <dbReference type="KEGG" id="sali:L593_00865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.178"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OrthoDB" id="18705at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="120"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="418" mass="46220" checksum="1B597BBDAB930347" modified="2013-07-24" version="1">MARYHIETYGCTANRGESRQIERALRDGGHHEATGPDDADVAILNTCTVVEKTERNMLARARELDEETPGDLVVTGCMALAQGEQFREAGVDAEVLHWDEVPSHVRNGECPTTTPDAEPILDGVVGILPIARGCMSDCSYCITKQATGKIDSPPISENVDRARALVHAGAKELRITGQDTGVYGWDDGERTLHTLLDRICTEIDGDFRVRVGMANPKGVHGIREELAEVFAEHDELYNFLHVPVQSGSDDVLGDMRRQHQVSEFLDVVEAFDGALGEWTLSTDFICGFPTETDADHEQSMALLREVRPEKVNVTRFSKRPGTDAAEMKGLGGTLKKERSKEMSEVKRDIVGEAYDDLVGQERSVLVVEQGTEHSVKCRDDAYRQIIVRNAEERGIEPGDRLTVEVTSHQTMYAFGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D2</accession>
    <name>R4W6D2_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447126.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11435"/>
    <dbReference type="EnsemblBacteria" id="AGN02232">
        <property type="protein sequence ID" value="AGN02232"/>
        <property type="gene ID" value="L593_11435"/>
    </dbReference>
    <dbReference type="GeneID" id="16181464"/>
    <dbReference type="KEGG" id="sali:L593_11435"/>
    <dbReference type="eggNOG" id="arCOG06313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165238_0_0_2"/>
    <dbReference type="OrthoDB" id="117135at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9613" checksum="538DD181D894C70D" modified="2013-07-24" version="1">MHRPELASDLQSAFDADPDVARVVARAAGDLSDSGAYRDDVGSAIDGTLIVAELQDAPADSDLVERWNWWIGSLELAYGDYEQFLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H0</accession>
    <name>R4W6H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445272.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02135"/>
    <dbReference type="EnsemblBacteria" id="AGN00378">
        <property type="protein sequence ID" value="AGN00378"/>
        <property type="gene ID" value="L593_02135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180084"/>
    <dbReference type="KEGG" id="sali:L593_02135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.433"/>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_8_2"/>
    <dbReference type="OrthoDB" id="100431at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="14059" checksum="9D368930507D2549" modified="2013-07-24" version="1">MRRDDRDDPFDDIFREIERLMDDVMHGDAPTIDETGFGGDAHVDVHETDELVRVVADLPGVERDDLALRCDGEVLTLDVESEHRHLQERITLPATVDEHSADASFNNGVLEVTFDRTDDSASINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H3</accession>
    <name>R4W6H3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447211.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11870"/>
    <dbReference type="EnsemblBacteria" id="AGN02317">
        <property type="protein sequence ID" value="AGN02317"/>
        <property type="gene ID" value="L593_11870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180809"/>
    <dbReference type="KEGG" id="sali:L593_11870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2443"/>
    <dbReference type="eggNOG" id="arCOG01674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_2"/>
    <dbReference type="OrthoDB" id="111329at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="5">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10769" checksum="999AE8B85BB3D0CB" modified="2013-07-24" version="1">MSEQTEDRRRAHVFVTGRVQGVFFRATTRDRAEAVGVDGWVRNLEDGRVEAVFEGTDEQVTEMVEFCHEGSPAASVEAVEVEREPPEGLSGFDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6V7</accession>
    <name>R4W6V7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">thrS</name>
        <name evidence="13" type="ORF">L593_13040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447441.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13040"/>
    <dbReference type="EnsemblBacteria" id="AGN02547">
        <property type="protein sequence ID" value="AGN02547"/>
        <property type="gene ID" value="L593_13040"/>
    </dbReference>
    <dbReference type="GeneID" id="16180351"/>
    <dbReference type="KEGG" id="sali:L593_13040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2673"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_2"/>
    <dbReference type="OrthoDB" id="11656at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="272"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="9">
        <location>
            <begin position="248"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN02547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="648" mass="74188" checksum="8C6B028FA02CE292" modified="2013-07-24" version="1">MSQQESDVIAVVLPDGSELEVPRGSTIEEIAYEIGPGLGDATAGGRIDGELVGKELAVTEDGAEIEIVTEDSDEYLRVMRHTAAHALAQAVQRHYDDVDLAIGPPTDDGFYYDFDDLDVDEDDLPAIREEMEAIVEEDLDVEYERVSIEEARDRLADQPYKLELLEEFAEEDDTVHFYSQGEWEDLCKGPHVESTGEIGAVDLLEIAGAYWRGDEENEMQTRIYGTAFRSEDDLEAFLERRREAEERDHRKIGNEMDLFSIQDRTGPGLPLYHPNGKTILRELEGFVEDLNLDADYEYVETPHVFKTDLWKESGHYDNYADDMFLFEVGDDEFGLKPMNCPGHAAIFDDSAWSYRDLPIRYAENGKVYRKEQRGELSGLSRVWAFTIDDGHLFVKPDQIQAEVERIMDMIKEVLDTFGLDYQMSLATRPEKSVGSDEIWEKAESALESVLEDRKLDYGVEEGDGAFYGPKIDYEFEDAIGRSWDGPTVQLDFTMPEQFDLSYVGEDNEEHRPVMIHRALYGSYERFFMMLIEHFEGKFPLWLAPEQVRVLPITDDNAEYAESVAAELDDAGVRVEVDESDNRLQRKIRAAHDDRVPYQIIVGDDEQEDGTLSVRDRKERQEHGVDPDDFYAHLEAERAEKRTEPDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W7</accession>
    <name>R4W6W7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447456.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13115"/>
    <dbReference type="EnsemblBacteria" id="AGN02562">
        <property type="protein sequence ID" value="AGN02562"/>
        <property type="gene ID" value="L593_13115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180399"/>
    <dbReference type="KEGG" id="sali:L593_13115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2688"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_4_1_2"/>
    <dbReference type="OrthoDB" id="78782at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="167" mass="17850" checksum="806E772EA93A1D7C" modified="2013-07-24" version="1">MLVGIISDTHDNVAAVERAVDVFEARDVETVVHCGDVIAPPVVPFFEGLEVHAVLGNNDGELDGLESAFRDLGNGSELHGRFAVVSFDGFEVAMLHGEDLDEVDDLAAGGEYDLVCHGHHHEAEQREVDGTTVLNPGGHFPTIPAEHRSVAILDTDDGSVEFVNVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W700</accession>
    <name>R4W700_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03560"/>
    <dbReference type="EnsemblBacteria" id="AGN00663">
        <property type="protein sequence ID" value="AGN00663"/>
        <property type="gene ID" value="L593_03560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.723"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="28544" checksum="2C488A8D452664DE" modified="2013-07-24" version="1">MADGGSASDGGAASDNDDLAIRASGIDKAYDSWFPWEPTVEVLDDAAIEIERGELVGIVGENGSGKSTLMQILVGALAPDAGTVERGGTVGWCPQDPLLYDRLTVRETMRLFGEAYGLDEDRRRERVDWLTDRLDFAKYLDTRIDRLSGGNRQKVNLSVALLHDPDVLLLDEPYTGFDWETYLAFWELTDELAAAGTAIAIISHFVEDRDRFDAIYELRDGGLREDGRKDGREEAAEHADSAVPGSAGDAAQVDRSSEVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B6</accession>
    <name>R4W7B6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GATase1_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445767.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00873">
        <property type="protein sequence ID" value="AGN00873"/>
        <property type="gene ID" value="L593_04620"/>
    </dbReference>
    <dbReference type="GeneID" id="16181027"/>
    <dbReference type="KEGG" id="sali:L593_04620"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.944"/>
    <dbReference type="eggNOG" id="arCOG02907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074816_0_0_2"/>
    <dbReference type="OrthoDB" id="54699at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010768">
        <property type="entry name" value="GATase1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07090">
        <property type="entry name" value="GATase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase1_like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="26797" checksum="57602D78E6010FA3" modified="2013-07-24" version="1">MTDVLLAGESWSSTSLLVKGRDVATATEYTEAADHLIEALESVGASVTHMPGDVVVRDFPRSKEALDEYDLVLLSDIGAQSLLLTPQVSAGQTDVNRCRLLGEWVAEGGALGMLGGYTSFAGEGGAAGYARTELADVLPVEIAHHDDRVETPEGAVPQNVGLSELPEEWPHVLGYNKLTADPDAEVLARVRDDPLVVIGEHGEGTTLAYATDCAPHWAPMEFLEWEHLPDMWDALLDRLVRAEAESARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I4</accession>
    <name>R4W7I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05170"/>
    <dbReference type="EnsemblBacteria" id="AGN00983">
        <property type="protein sequence ID" value="AGN00983"/>
        <property type="gene ID" value="L593_05170"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05170"/>
    <dbReference type="eggNOG" id="arCOG01834">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_15_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="13638" checksum="059FD7E20BE24683" modified="2013-07-24" version="1">MRPSTSWTRGIDLPNQLFETGSDDYELYEADDEFVLTVELPGFDLEDIAVSWDDGVLNVSAEHEDEQRGRQKTYHRRFRFPKRIVEEEIDAEYTNGVLEITLPVESGATARGTEIEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7M0</accession>
    <name>R4W7M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="426" mass="44029" checksum="36CB4BA4C9D1B24A" modified="2013-07-24" version="1">MGVTGQDADPVLYPNRGKASTSTSGVSRRDVLAGGAAAGAVATAGCTGDGGESAPTDRPTVFVFNTGDGTVSLLDSESDELVETRAIDLSSSFPSNQYTPDLTDAPEDSLWLNVGRGVRGLEVGSLSETAAVETGSGANWLERTPDGAHVVVSAREPSHAQFRIDADRTTEAFGEVTAEIDRTPEGGLGDRDGPGPCDVTIHPDGEYAYVPDLFGDTLTVLSVDPFEIVTQIDVDPVGDGPARPWMGTVAPDGETLLVEHDEGEAGTESIWSLADPAEPRLTARLTTADGLGRRPLTSEIGPDSATGYVFTPGSNDVTLVDLAAGTVTERLDVGGAAFAGTWEPDRSKLYVSVQTADEVAVVDHERGAVVERIGVGPSPYGATAARVRPGSDAGASMQLAVARLGIGSDRAETTYCIGNCACGHRL</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN01088">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="139"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="41967" checksum="C233AD54B9EBDA9E" modified="2013-07-24" version="1">MARESAANSDLVSRRKIILTTGAAGAAALAGCSSGDGDDSDDGGSDSGSDSGSDSGSDSGSDNENTDGNESGSMDTSVLTADGSSTVYPITNTGGSYWNSNPEAGDEDYWPNSWAQEEYDTQMRLADFFAQDYGYEATEERSNPPFRASIALSHSGTGVEGVMEERIDIGDSSAPAEAELAGTDPSEETLNNFVDHVVGVDGQPIVVSREIADAGVEQITIEELRGIYRQEITNWSEVGGPDRDILALGRSAGSGTDTAFRANVYGDPEASISPDQRFGQNQQLQQAVTQADNAIAYIALAFVEPDGGTPPIGLEIDGTLYEYGTNLGAQDYPLSRDLHAYTWEDTSRKEACFINFLLSDFGQEIFVAGNNYFKLPQDRLETQREMVAASNYE</sequence>
</entry>
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    <accession>R4W7R6</accession>
    <name>R4W7R6_9EURY</name>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446037.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01143">
        <property type="protein sequence ID" value="AGN01143"/>
        <property type="gene ID" value="L593_05970"/>
    </dbReference>
    <dbReference type="GeneID" id="16180518"/>
    <dbReference type="KEGG" id="sali:L593_05970"/>
    <dbReference type="HOGENOM" id="CLU_2748362_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7951" checksum="D1F7AB098968239A" modified="2013-07-24" version="1">MNDVEHLSENTVQLAKHVARRHPELSEGASLEEIIRTLAEEHLSSESVDSLETEEAIAQKQEELMEIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S5</accession>
    <name>R4W7S5_9EURY</name>
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        <submittedName>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01242">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9887" checksum="61AF40F5BBF1131A" modified="2013-07-24" version="1">MEGWVVDKGIVTDIIDEWDHRFLLEKSDPLAKAFEEAGEGESLLLLDHPPTAEVMSLELERELEEELPENVSNASVTVRETGELCATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S9</accession>
    <name>R4W7S9_9EURY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="16181639"/>
    <dbReference type="KEGG" id="sali:L593_06120"/>
    <dbReference type="eggNOG" id="arCOG00394">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985598_0_0_2"/>
    <dbReference type="OrthoDB" id="59810at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="32263" checksum="D5A0B10A95C05698" modified="2013-07-24" version="1">MTDPDQGYLLNTIQNPRSLKPVYESVNRGNTTEDEIVDDTGLSADAVDEGAKGLLRLGLLDSKDEEYTVRDYTWSTGDEILDFQLTALENLASSLTPPDWGKQAVLHLNYAYLIKEDYQRINDKDEAVRKQMDRWERDTLEYYPTYRGDRLDLNPNKMENWGRLATYLGLLHQYETHEFTVYPDPSLIYHSIKRAHNAAGRTVDGNPVIEVPTYLDWLSNNLLYLPEDTGGVPAILSRSLYQLMNEERIRLAEIGDQGAVAFDRMPTHDRREQSANSIVITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V6</accession>
    <name>R4W7V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_06430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446127.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06430"/>
    <dbReference type="EnsemblBacteria" id="AGN01233">
        <property type="protein sequence ID" value="AGN01233"/>
        <property type="gene ID" value="L593_06430"/>
    </dbReference>
    <dbReference type="GeneID" id="16179908"/>
    <dbReference type="KEGG" id="sali:L593_06430"/>
    <dbReference type="eggNOG" id="arCOG02798">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="28946" checksum="8008045C87D50B03" modified="2013-07-24" version="1">MHGRETDRVKAIGTALEILEILRDANGARVTEVADELGVSKSTVHDHLATLRERGFVERDGDRYVVGLRWLRFGGHARDDLELFQHGQIPATNLARETEELSVLSAFYGTNSVPVYQARGSKAVTTDSYPGLELPIHATATGKAMLANLSTETFEAVLDEIDLDRHAKNTIVDEDELREDVQRTRERGFSLDDEERIDGMRGIGAPITHEGSGEVLGALAMTGPTHRVRGERFREEYPQLVSNVAREIEINVTHQRAQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X0</accession>
    <name>R4W7X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-binding protein MutS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutS2</name>
        <name evidence="6" type="ORF">L593_06630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has ATPase and non-specific DNA-binding activities.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446167.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06630"/>
    <dbReference type="EnsemblBacteria" id="AGN01273">
        <property type="protein sequence ID" value="AGN01273"/>
        <property type="gene ID" value="L593_06630"/>
    </dbReference>
    <dbReference type="GeneID" id="16181824"/>
    <dbReference type="KEGG" id="sali:L593_06630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1353"/>
    <dbReference type="eggNOG" id="arCOG02895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026764_0_0_2"/>
    <dbReference type="OrthoDB" id="9037at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00971">
        <property type="entry name" value="MutS2_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012401">
        <property type="entry name" value="DNA-bd_MutS2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029254">
        <property type="entry name" value="MutS_C_archaeal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="5">
        <location>
            <begin position="508"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="515"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="692" mass="73434" checksum="6BD9B663F8A9AC3E" modified="2013-07-24" version="1">MDLEAIPGVGAKTAESLETLDDPERALREGDVARIAEAPDVTPGRAARIARGAIRAEHDDPGGFLGTSRAREIHSELLGLLQERTVTDYAAHRLETFYPSPAASRIAEARSIATAAMERDPEEAVLEALEGVEPLSAPSDVRVRDRCLATTDAERYAEAQEAIPEVAIEVVDDARGLAELARGYATVVALDESFAGVDVDGDVRVEPDALDRPQDVVPERTLAFFAANREALAAAIDVHRAAALDAPLDLDELEDALDRLGEDGEPVGDEELQRLQTALDDLDATVSTAESVATDHLRDSLRERDVTVEGADLLSLVEQGAGVDSILDRELADEHAEAVEAAREHLVDALELGPAEAERAHRIIPDDPTFPVERNEDAMSRLRESLRADAERRAAKRKRELADDLAGMREDARALVRAALELDVELAIARFARDFECTMPRFADPELAAAADSAGEPAAAPDGIGVDPEADAATAERTGPGWIAIEGGRSPLLDEPPDAIEPVDYAVGGVALLSGVNSGGKTSTLDLVAATVVLAQMGLPVPADEVALTRFDALHYHAKTQGTLDAGAFEATVREFGDLAAGGEGALVLVDELESITEPGASAKIVAGVLEALDDQGATGIFVSHLAGEIAETASFDVAVDGIQAEGLEDGELVVDRSPRKDHLARSTPELIVEKLAEEQGEDFYEDLLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y3</accession>
    <name>R4W7Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446207.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06830"/>
    <dbReference type="EnsemblBacteria" id="AGN01313">
        <property type="protein sequence ID" value="AGN01313"/>
        <property type="gene ID" value="L593_06830"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1395"/>
    <dbReference type="HOGENOM" id="CLU_2766271_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="69" mass="6635" checksum="3068BE05B4629D0F" modified="2013-07-24" version="1">MPVPGARIVGGTADSGTTVGGTADSGTTVGGTADSGTTVGGTADSGTSKAARSTGGRRRPSGRQRDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W800</accession>
    <name>R4W800_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07105"/>
    <dbReference type="EnsemblBacteria" id="AGN01368">
        <property type="protein sequence ID" value="AGN01368"/>
        <property type="gene ID" value="L593_07105"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1452"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="389" mass="40793" checksum="E72D2C6F9397370B" modified="2013-07-24" version="1">MQSQHAPSESTGQAAATAASAADSDDGPAAIRAEDVHVTYADGTEAISGVDLAVEPGECFGFLGPNGAGKSTTIQTLVSLLHPTRGSVTVHGHDVVEDAQAVREYVGYMPQETSVDPELTARENVRFAARIHGVPAAEREERVEELLDVVDLTTVADDLAETFSGGMAKRLDAANALVHRPPVVFLDEPTTGLDPEARMELWDYFEAINDAGTTVFLTTQYLEEVDRLCDRIALLQDGEVVATDTPAALKAAVGGDVLELTLAGVDDTLAEDRTGESGAAGSIDESGGVGGTELRDHAASVVRSANAFDDPTVERTDEGLAITADDVRTGVMELFVAFHDAGLTVTGVDVRSPTLDDVFLSLTGEQIDEAETATGSEPRSGADVEEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W818</accession>
    <name>R4W818_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Ribosomal protein L24E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01355"/>
    <dbReference type="EnsemblBacteria" id="AGN00224">
        <property type="protein sequence ID" value="AGN00224"/>
        <property type="gene ID" value="L593_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01355"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152994_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11265" checksum="8809A971497C2FDB" modified="2013-07-24" version="1">MFVRTDGTTIHYCSSKCEKNAELGREPRDLEWIQDEEAERLARAEEGAEESVEESVEEPDVTEEDSEDDSADADEAETSDEADADETEADDEDVEEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W820</accession>
    <name>R4W820_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin-independent synthase MetE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445123.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01380"/>
    <dbReference type="EnsemblBacteria" id="AGN00229">
        <property type="protein sequence ID" value="AGN00229"/>
        <property type="gene ID" value="L593_01380"/>
    </dbReference>
    <dbReference type="GeneID" id="16182776"/>
    <dbReference type="KEGG" id="sali:L593_01380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.281"/>
    <dbReference type="eggNOG" id="arCOG01877">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OrthoDB" id="88155at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="337" mass="36498" checksum="99ABC306166BFF83" modified="2013-07-24" version="1">MTELVSTTPGLYPLPDWAKRDLEELKGHQKHDLIDGTEGAEITGVYEEAREEVVTQQLDAGLDLVVEGQLRWDDMLAHPLAVADAVDTRGIVRYYNNNNFYREPVVTDDLEASGDVAAELEAAAEITAEHESDADLAAVLPGPYTLADLATDEHYGDEAEFVDAVAAFLADEAEQFPDVAHLTLLEPSLVEAAPGEGLDERASQAIDTVATAIDAEVAVQPVYGALDERVYAHLLDADIDAVGFDLVSDHDANVYNAQEYGATDDVLLGLVDGRNTLVESADTIRERVEWFQEQTPAADYGRIYATANTDLFFLPTNRFGEKLEALGAAAATTEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W826</accession>
    <name>R4W826_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446337.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07490"/>
    <dbReference type="EnsemblBacteria" id="AGN01443">
        <property type="protein sequence ID" value="AGN01443"/>
        <property type="gene ID" value="L593_07490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182135"/>
    <dbReference type="KEGG" id="sali:L593_07490"/>
    <dbReference type="eggNOG" id="arCOG06339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052186_0_0_2"/>
    <dbReference type="OrthoDB" id="84997at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="26089" checksum="1A8CBAB0841757B5" modified="2013-07-24" version="1">MTRTSTLLLVTAMAILGLAVAPGAVAADGELELEVEQADDGSATVTVTHDDAAAANASVAVGTVDENASYDGTGEYTTDANGAVSLVAPNESVGIVLNATAANHSTSTTATLELPEDEDANETEEDEDVNETDEDEDANETDEDEAANGTESGFGQLVSDFVNSLDANESEGGIGYAVAAFVLDNNPAADHIPDFAGPPANASERGGPGENGPDHAGPPANASDSAGNQTAGGPPEGAGETGDGGPPTNAGPGDDDGGTETESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W881</accession>
    <name>R4W881_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446452.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01558">
        <property type="protein sequence ID" value="AGN01558"/>
        <property type="gene ID" value="L593_08065"/>
    </dbReference>
    <dbReference type="GeneID" id="16180196"/>
    <dbReference type="KEGG" id="sali:L593_08065"/>
    <dbReference type="HOGENOM" id="CLU_2230489_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11916" checksum="F8F44683DE0D900D" modified="2013-07-24" version="1">MGIEQFRVQIEEAKRRAAEAEDEQVADRYRQHADLLESVESMLSAQQRLIDRKNESLEALTGLLLTFHGQYGEELDGEAADQLDLIAEAARDVKQSIENEQKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W891</accession>
    <name>R4W891_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AGN00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="40" mass="4240" checksum="32FA5C498CD46E88" modified="2013-07-24" version="1">MAHLRHANQSDCPQCGATTLNVQGLADCPQCSWLDPADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G1</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
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            <end position="84"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="727" mass="81223" checksum="14248881964EF530" modified="2013-07-24" version="1">MFDPSAPEDASEVLDRFVDNLPGIAYRCEPEAPWKMTFLRGQVESLTGYDSAEFEANDVSYGSLVLAADHDDLERTVQRAVEERRQFTANYRIETRTGETKHVFERGVPVVENGGTTALEGIIVDVSQRKAYQERLHRQNDLFAHTQQLANVGGWELDSTSETLRWTDQAKRIHGLPLQASPSVDEAIEFYHPEDRPVIRNAVDRALAEGEPFDHELRIRTTHGEQRWVKTRGVPQVEDGEVVRLRGAIQDVTERLEREQSLRSEQAFTESILEAIPDPLYAFDETGSFTRWNDRFEEVTGYIDAEIAGMSPLDFVAEADRDRVREHVQRVLERGEATTVRAALRTKSGEEIPYELTGAPRETDADAHAELVGIGRDVSDRLQRERRFEAVFNNTYQFTGLVDTDGNIVEVNQAGLAFAGASRDDAIGTPLWDALEFTGEADEEAVKRGFQRAIDGEIFRDELRVVGHDRVAVIDFSIRPITDRDGEVTLLVPEGRDISEIKERERLLHVLHRLLRHNIRNDLNTVRGYADLVAEEIDDEATLDHLDRLTDAATNLLTTSEKAKVMMDSILDPHRGSEPAELRSSIESVAKRQRSQFPAATIEVRVDASGPLPVDPRVEVAVEQLVENGVEHNASEAPAVTVTATREGADAVVEIVDDGNGIADDEWAMVDAEVRDEQTQLRHGSGMGLLLTRWIVDDVGGQLAYDDRDTEGSVVSLRLPLAGGTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K4</accession>
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            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="185"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="29795" checksum="B99B4B6DC80B12F9" modified="2013-07-24" version="1">MQTRRLRAGLVLLLAVVALGAAGAAVDSGRSGGGSTGLGEGSGSGAGSGADGLPSISPEFNPFFDGGILAAAIGVLAVVGLVAALVGGTLLLLEKDWDELKEYLFSAGIKVGVFALVGIGFYLLMQLFDGLPDGGGSTGLGGGSEDVEAAGEAASSTGLQLPTVVGIVVVAAILLFIVVTTLGGGSEEDGEAVAATPDPEESPGGIGTATPTSTTVGRPPADNEIYRAWLALAEEANADARRETPAEVADRAVAAGVDEAATREITSLFERVRYGGVEPDEATEQRAERALARMAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
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    <name>R4W8P0_9EURY</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <begin position="440"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="767" mass="80620" checksum="FEAB64354E85A928" modified="2013-07-24" version="1">MIAAGIFSLSGTAVAEIGASAVIAFVLAAVIAGITAASYSEFASIYSENGGGYLFTSRTFDGRDLLTYGIGMSLFLGYTGTTAFYLATMDEWFVRFIIPEQLSFLPHGTSGVTAAVLLGVLNARGTEESGTFQVIVTGAKVAVLIAFIAGAFSYAGPADATTTFSSQFSTDVGGIVSIAALAFITFFGFSAIAASAGEIIEPRKTVPKAIAASIVTVTILYAFVIVAMTNSPVPAEVVAQEGETAMGRVAEGFLGPIGQSLIVAGAVFSMISASNASILAASGIGSLMGRQGQAPRSMTRIHPDFGTPFWSVTTATATIVAMIVGFIVVFPAHGGPTPLDLGLEALTGFATFNLLLPLAVVNTALILHRRKFPDIERGFRVPGVPVVPILGILANLALITNLPVKGVGTGVALTLSLVLVYLAWGGRPDVEELFQRVREPTATPASTSTGGDSHVEASAGRAGAEEQSDLEAPESAASGTADEDRFRILVPIARPEDASKYVALAEHLAQGRDRTPIVQVLTVTKIPDQTPHEMVSDTARLRADRIEDILAEDEHSIEYTVEGHTCRDVAFDIIQTARNDEVNLILMGYPEESGGVTETVAYQAPCDVVFASGFVGDETFETVAIGAGGGPHHGGAMPMVRALGEQGAAVDVVSVDPMGPGTPEDPEGTVEQLPDLQELEVHTVDAPTVEEGLVDVARREGAVLVIGASRDRRLSQWVFGSTPDRVVRRADEVDVPVLVYAQPSGVPERIEDSLFPVYRYVRYQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q8</accession>
    <name>R4W8Q8_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="91" mass="10110" checksum="8758B4B76818A564" modified="2013-07-24" version="1">MTGGWEIVLVIVRVLLLGLGVATTAISYRAYRRRRTRYLRNATVGFGLITLGVLIEGFLYQLTQLTLTQVHVVESVALSCGLAVLLWSFLQ</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Put_antitoxin"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02018.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="72" mass="8316" checksum="9C5F672DE6183898" modified="2013-07-24" version="1">MYALCIHMSTSIRVSEETKAKLDLLKRDDETFDELLRRLAGETEPIEIGAWDDETADRAREAVDRSRESFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S6</accession>
    <name>R4W8S6_9EURY</name>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="15142" checksum="CCA6A6CF572C2740" modified="2013-07-24" version="1">MPVHLLVPMAGSPLSKRALEHACSMHPGARITVLYVVEDVEESYAARALVGADELEERGRERAEAVFEDARAIAEDHHVPIDTEIVVGKPAREIVAFAVDHDVDQIVVGSHGRSPMSRVLLGSVAQSVVRRAPVPVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U9</accession>
    <name>R4W8U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="9" type="ORF">L593_05000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05000"/>
    <dbReference type="EnsemblBacteria" id="AGN00949">
        <property type="protein sequence ID" value="AGN00949"/>
        <property type="gene ID" value="L593_05000"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1019"/>
    <dbReference type="eggNOG" id="arCOG00906">
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    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="58"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6568" checksum="7712F5F3B6A63A9D" modified="2013-07-24" version="1">MKSDIHVCSAWKDEHERPVYTLGDACPECGAEAVNSAPAPFSPEDPHGEYRRRARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V9</accession>
    <name>R4W8V9_9EURY</name>
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        </submittedName>
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        <name evidence="2" type="ORF">L593_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02128">
        <property type="protein sequence ID" value="AGN02128"/>
        <property type="gene ID" value="L593_10915"/>
    </dbReference>
    <dbReference type="GeneID" id="16181375"/>
    <dbReference type="KEGG" id="sali:L593_10915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2252"/>
    <dbReference type="eggNOG" id="arCOG00449">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="214" mass="22452" checksum="CDD30D49F27778D1" modified="2013-07-24" version="1">MYDQFLLPTDGSDGTDRAIDHSLELAGTYDATLHVLSVLDDASLTSVSEEAATEVLADREAAVEAVANAAREAGVDVVTSVREGSPHREILAYADEAAVDVIVMGTHGRSGVGRVLLGSVTERVVRDAPVPVVTVRMDGGRGAGGETEHVTTPAAAERRARAALEDEGHDEVTIPEDPYRTTTAWVVPATADGGTYNVHVDADTGATRIGRLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W949</accession>
    <name>R4W949_9EURY</name>
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        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12125"/>
    <dbReference type="EnsemblBacteria" id="AGN02368">
        <property type="protein sequence ID" value="AGN02368"/>
        <property type="gene ID" value="L593_12125"/>
    </dbReference>
    <dbReference type="GeneID" id="16179839"/>
    <dbReference type="KEGG" id="sali:L593_12125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2495"/>
    <dbReference type="eggNOG" id="arCOG00624">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111003_1_0_2"/>
    <dbReference type="OrthoDB" id="85082at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="52"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="19900" checksum="E52FFFC5797CE183" modified="2013-07-24" version="1">MDARGSVWTIYRESLPVLLASLAGGIFAGFVLGTPAMVEGFESYPGLLLALPAFLATRGNVYGALGARIASGLHQGIVEPRLLWQRRLVNAVAAAVINGLTMSAFIALASWTILSVQPGRSPAPLFELVGVLVLAALATATVLIVGLLALVFAGYRRGVDPDNLIGPIVTTLGDVFGVVFLLVSMTAVGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W956</accession>
    <name>R4W956_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447292.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12285"/>
    <dbReference type="EnsemblBacteria" id="AGN02398">
        <property type="protein sequence ID" value="AGN02398"/>
        <property type="gene ID" value="L593_12285"/>
    </dbReference>
    <dbReference type="GeneID" id="16179841"/>
    <dbReference type="KEGG" id="sali:L593_12285"/>
    <dbReference type="HOGENOM" id="CLU_1881160_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="14624" checksum="E3C70820A3DEA396" modified="2013-07-24" version="1">MSLFEKIGLGGGDSEAESDAESSREVEDTGPNFMPEKQRELYVKAYENKLDLSDSGTCSECGTTLKPVKADELLASCKNEDCENHLNETEINGAKRFYDRNGHPDDLDGGKAAATDGGDGERNALDGLRNAMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B6</accession>
    <name>R4W9B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446248.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07035"/>
    <dbReference type="EnsemblBacteria" id="AGN01354">
        <property type="protein sequence ID" value="AGN01354"/>
        <property type="gene ID" value="L593_07035"/>
    </dbReference>
    <dbReference type="GeneID" id="16181985"/>
    <dbReference type="KEGG" id="sali:L593_07035"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="OrthoDB" id="25689at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="448" mass="49680" checksum="CE0E46C9230F8AA9" modified="2013-07-24" version="1">MNEIRNVLLVSVDCLREDVFKAGLEEGLFPNCAALYDGALEFTETYTVANTTDPSLTAFMTAKYPFEHGVVENGWGLDETHDTAGENFQAAGMDTFGVVSVDHLAADHSKLDRGFDRYEDGQAYGKLYPILSRIYDTKTFNTVFGAVKNLGIGRYTVKNLLRDLGLISLHCRSARSVTDDAIACLDDVAPKFAANGDGADANGEDASGTDDEESGFFGWVHYFDVHEPRNAPRNLLEDHDEYTAAMMRVDDHVGELQDELEARGIADETLVVFTGDHGEALGEHGYEGHGRTLYDEELNVPLAFDHDALPDEQIDTQVRTIDILPTLLSLVDADPLDAAGEPIVTAPDDDPAEESRQLFTMAYPTFGDAVATRTPDWKLIRDREDDVEELYDLESDPDERDDLVDEHGQRREALAGDLDSWLATFGEIERQEVDEDTEEMLADLGYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K0</accession>
    <name>R4W9K0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit Rpo7</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpo7</name>
        <name evidence="5" type="synonym">rpoE</name>
        <name evidence="8" type="ORF">L593_13895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447612.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13895"/>
    <dbReference type="EnsemblBacteria" id="AGN02718">
        <property type="protein sequence ID" value="AGN02718"/>
        <property type="gene ID" value="L593_13895"/>
    </dbReference>
    <dbReference type="GeneID" id="16180939"/>
    <dbReference type="KEGG" id="sali:L593_13895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2843"/>
    <dbReference type="eggNOG" id="arCOG00675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117966_0_0_2"/>
    <dbReference type="OrthoDB" id="117241at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00865">
        <property type="entry name" value="RNApol_arch_Rpo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046399">
        <property type="entry name" value="RNApol_Rpo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="PTHR12709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="SSF88798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="190" mass="20842" checksum="60E39E8B52A82C94" modified="2013-07-24" version="1">MYKRVRVTDTVEVPPEELANVTPELVKRLLQDKLEGLVDEDLGSVVSVTEVHDVGQGRVLPNRPGVYYTAEFDAVTFDPQMQEVVDGVVVEVVEFGAFVGIGPVDGLLHVSQISDEYLAFDGENRQLASNESNRVLAEGDSVRSRIVTKSIDERNPRDSKIGLTAKQPGLGKHGWLEEARQTEDVAAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M0</accession>
    <name>R4W9M0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ORF">L593_08420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 8 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446523.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08420"/>
    <dbReference type="EnsemblBacteria" id="AGN01629">
        <property type="protein sequence ID" value="AGN01629"/>
        <property type="gene ID" value="L593_08420"/>
    </dbReference>
    <dbReference type="GeneID" id="16182399"/>
    <dbReference type="KEGG" id="sali:L593_08420"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1725"/>
    <dbReference type="eggNOG" id="arCOG00618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_2"/>
    <dbReference type="OrthoDB" id="89881at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="25605" checksum="C7214A2EC3287DB3" modified="2013-07-24" version="1">MTTDAFTVVPAVDLRDGEVVQLVQGERGTDRRYGDPVEAAERWLDQGATTLHLVDLDGAFEGERINADAVERIVETVPETVTVQLGGGIRTVDDAVELLDLGIDRVILGTAAVEDPDIVAAISERRPDSVVVSLDAKDGEVVVEGWTEGTGLAPAEAAQRYADLGATGILFTNVDVEGKLEGVRTEPVADLVDAVSIPVIASGGVATIDDVLALREAGAASVVVGSALYEGEFTLEAALAALDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M9</accession>
    <name>R4W9M9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447702.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14345"/>
    <dbReference type="EnsemblBacteria" id="AGN02808">
        <property type="protein sequence ID" value="AGN02808"/>
        <property type="gene ID" value="L593_14345"/>
    </dbReference>
    <dbReference type="GeneID" id="16181867"/>
    <dbReference type="KEGG" id="sali:L593_14345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2937"/>
    <dbReference type="eggNOG" id="arCOG10156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162433_0_0_2"/>
    <dbReference type="OrthoDB" id="129443at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11279" checksum="3961BBB84959DE7A" modified="2013-07-24" version="1">MTPDPPPADDDTADLDESLEAIHEHLAATQELPVERTPSRWIGEAEAVAADLATADLDAPVVRERLGHVRSLLSEVETTGDDAADDHLSRARSVTETAIDRLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R6</accession>
    <name>R4W9R6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447827.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14995"/>
    <dbReference type="EnsemblBacteria" id="AGN02933">
        <property type="protein sequence ID" value="AGN02933"/>
        <property type="gene ID" value="L593_14995"/>
    </dbReference>
    <dbReference type="GeneID" id="16181761"/>
    <dbReference type="KEGG" id="sali:L593_14995"/>
    <dbReference type="eggNOG" id="arCOG08921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168712_0_0_2"/>
    <dbReference type="OrthoDB" id="122629at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9321" checksum="B3B86A705E2B6302" modified="2013-07-24" version="1">MTSVRFYAGIYVLLVALVSMKIVFFETLSYDVALALTMLSAVAEALVIAGYYQHLRFEPRSLSYLMTMGVAGVLLVTFAAAFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y5</accession>
    <name>R4W9Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446908.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10345"/>
    <dbReference type="EnsemblBacteria" id="AGN02014">
        <property type="protein sequence ID" value="AGN02014"/>
        <property type="gene ID" value="L593_10345"/>
    </dbReference>
    <dbReference type="GeneID" id="16180854"/>
    <dbReference type="KEGG" id="sali:L593_10345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2133"/>
    <dbReference type="eggNOG" id="arCOG04689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057816_0_0_2"/>
    <dbReference type="OrthoDB" id="81748at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="30519" checksum="AAF3FB16254B1E9F" modified="2013-07-24" version="1">MGVRCTLLGHAYGEAEIEREREERGDEAVVTIREVKTCSRCGDRSVVSENKEVTAVESAGSEVATPSDADAAPTSEPRPTEPGVDDTVAEESVEEAAVDAGPEGGEAGAADASEAGPEQDPETDDGVILDDEPDEEPAEREYGEWPDAEEDHASAEADPAAADEDANGGPAPWPDSDDEADEGFDAATPDDEPAADVEYPGSADAEPPGDGSGDAEASADAAEILDDEPATERPPADEGVDFERARETSSPSAPSTGGTELYCPACGYRDPSRDGSLREGDICPECKKGYLAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y6</accession>
    <name>R4W9Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446913.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10370"/>
    <dbReference type="EnsemblBacteria" id="AGN02019">
        <property type="protein sequence ID" value="AGN02019"/>
        <property type="gene ID" value="L593_10370"/>
    </dbReference>
    <dbReference type="GeneID" id="16180914"/>
    <dbReference type="KEGG" id="sali:L593_10370"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2138"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_4_2"/>
    <dbReference type="OrthoDB" id="104470at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="13875" checksum="85E63DA5A8B87F5B" modified="2013-07-24" version="1">MTFLDSSAIIDMLDGVERTVECVEAHGTPYLTSSICVFEVLEGVLGSGTTDVMAARQQFGGVRALEFNEDIAIEAARLQDALLADGEPMAPRDLLIAATARSTGDHLVVNDADFQTDVLEETISVTNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA52</accession>
    <name>R4WA52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRK potassium uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447243.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12030"/>
    <dbReference type="EnsemblBacteria" id="AGN02349">
        <property type="protein sequence ID" value="AGN02349"/>
        <property type="gene ID" value="L593_12030"/>
    </dbReference>
    <dbReference type="GeneID" id="16179983"/>
    <dbReference type="KEGG" id="sali:L593_12030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2475"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_2_2"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="23634" checksum="46261D6E488E3959" modified="2013-07-24" version="1">MKFVIVGYGRVGARTARILRSEGHEVLLVENDQEKVKRAQTEGFEVHEGDGTTEDAFEGIDLETVDALGGLTGDLNSNFAACMIGKHHGCRTVLRIDEDYREEIYEKYADDVDEVIYPERLGAAGAKTALLGGTFNVIADLTENLQLSVFEIGRDAPAVGKRVSEVDLPPSARIYAHGRSHDSLTIPLPGTQIDSGDRVAVIVETESVPGVREALLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA78</accession>
    <name>R4WA78_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Potassium transporter peripheral membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ORF">L593_12700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447373.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12700"/>
    <dbReference type="EnsemblBacteria" id="AGN02479">
        <property type="protein sequence ID" value="AGN02479"/>
        <property type="gene ID" value="L593_12700"/>
    </dbReference>
    <dbReference type="GeneID" id="16180193"/>
    <dbReference type="KEGG" id="sali:L593_12700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2606"/>
    <dbReference type="eggNOG" id="arCOG01959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_0_0_2"/>
    <dbReference type="OrthoDB" id="13082at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="228"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="444" mass="47765" checksum="76701E21E1456957" modified="2013-07-24" version="1">MRVIVVGAGEVGRTIATNLADSHEVVVVELDPELVDELTYAHDVLAIEGDGTDVETLREAGIEDADMLIASTDDDEANIVTCGAAKTISDAFTVARVKRHRLLETWRGAPGAFGVDFMVCTDLLAAQAIFRIAGLPGAQDVDAFAGGLIRMAEFEIREDSPVANQTVSEADRWESLTFAAIFRDGDVVVPSGVSRIQSGDRIVVIGSPENIRDFAEELAAEEDAEHGDIVIVGGSKVGHQTARVFEEHGKRPRLIEQNPDRARELAEILPDTMVLNNDATDREFLERESVGDADLVVACLDSDEKNLLVSLLAKRMGAERAVTVVSEGSYTDLFETVGVDVAVSPREETAEEIVRFTRAGRTEKVAMLEGDLAEVIEFEVDESSNLAGRTIVESTSELPDGIVVGAISRGGSLVTPRGDTVIQNGDHVVVFVDNEVLDTVLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSH5</accession>
    <name>R4VSH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445054.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01035"/>
    <dbReference type="EnsemblBacteria" id="AGN00160">
        <property type="protein sequence ID" value="AGN00160"/>
        <property type="gene ID" value="L593_01035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180775"/>
    <dbReference type="KEGG" id="sali:L593_01035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.212"/>
    <dbReference type="eggNOG" id="arCOG00776">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_1_0_2"/>
    <dbReference type="OrthoDB" id="88641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="16563" checksum="725F8517771F2CA5" modified="2013-07-24" version="1">MKFEDVEVGDVNEFGSYEMTEDEIVSFAEQYDPQPFHVDPAAAKEYPYGGLIASGWHTCSATMRMLVENQFRDGDNLGSPGVDELRWHQPVRPGDVLSVRVEVTEKRPLESDPERGLVKSRVETSTDDGTLVLSWKSNVFVRRDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTG7</accession>
    <name>R4VTG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445409.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00515">
        <property type="protein sequence ID" value="AGN00515"/>
        <property type="gene ID" value="L593_02820"/>
    </dbReference>
    <dbReference type="GeneID" id="16180344"/>
    <dbReference type="KEGG" id="sali:L593_02820"/>
    <dbReference type="eggNOG" id="arCOG03295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559551_0_0_2"/>
    <dbReference type="OrthoDB" id="104376at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="17605" checksum="B59EF0E72B9BB4E7" modified="2013-07-24" version="1">MAENGPVCPECGGPVAQTSTFCMHCSADLEDADRVDAEPTGADAADAADVAWDDSPDVADWRDGTPERESEWEGGTGGGAPEEPGDGDDVAAQGDLPSEYRSSGGTTSRRLLPDRFVTKAVTFVLSIVGGLTVGAVSAIVLGPLIPTGWAFLLVVVLWLGSTTVFLRIAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTH8</accession>
    <name>R4VTH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445424.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00530">
        <property type="protein sequence ID" value="AGN00530"/>
        <property type="gene ID" value="L593_02895"/>
    </dbReference>
    <dbReference type="GeneID" id="16180370"/>
    <dbReference type="KEGG" id="sali:L593_02895"/>
    <dbReference type="eggNOG" id="arCOG02274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092678_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25343" checksum="64ED509D2B17A341" modified="2013-07-24" version="1">MRSIRLAVAMPPDDRHPMHQYAMDHGGYTAYWQLHWQGRPDDGMTLLFYIEGPQEPYLEALEERVPDATHSVTDAEGNGFYLYVHADLDGLDRGLADAIDRPGVLLVPPLEYRMDGTLVASLVGPAEALSVTVDEIPDALDPEVLQVRPYGERSFRTAGALTDRQREIVDAALEEGYYEEPREASVEDVATATGCAPSTAAEHLRKAEAVVMERAATGPVTEPAVGRPAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTW9</accession>
    <name>R4VTW9_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Halocyanin hcpB</fullName>
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        <name evidence="7" type="ORF">L593_03595</name>
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    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00670.1"/>
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    <dbReference type="RefSeq" id="WP_020445564.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00670">
        <property type="protein sequence ID" value="AGN00670"/>
        <property type="gene ID" value="L593_03595"/>
    </dbReference>
    <dbReference type="GeneID" id="16180616"/>
    <dbReference type="KEGG" id="sali:L593_03595"/>
    <dbReference type="eggNOG" id="arCOG02921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052458_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
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        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017533">
        <property type="entry name" value="Halocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
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        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="halo_cynanin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="365"/>
        </location>
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        <location>
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            <end position="434"/>
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        <location>
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        </location>
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        <location>
            <begin position="234"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="445" mass="46151" checksum="C54948B0490C7F3A" modified="2013-07-24" version="1">MSEDDRLDRSGRVVSVTDRAGQLSRRRVLQTAAGTAAAAAAGAAATGTAAAQDEDGGEGVPAEFGNWFTGDARGGEVQNYDGTTVDRTGESEITVTVGADGNGGTFAFDPPALRISPGTTVTFEWVSDTHNVIVESQPEGAGWEGHDPIEDTGFSFTHTFETEGTYTYFCEPHLSLGMKGGIVVGPAPAGSGGGEGVPAEYGNWFTSDARGGEVQNYDGTTADQTGQSEVSVTVGADGNGGTFAFDPPALRISPGTTVTFEWVSDTHNVIVESQPEGAGWEGHEPIEDTGFSFTHTFETEGTYTYFCEPHLSLGMKGAIVVGAAPAGNGGQPGATAGGGGPPFWVTGLAGGIVAALLAPILVSYYRYWDRDERGRGTEAGRAAGIPAGEPIPEAAEPEPVEEIGHDEYDPMGTAALIVVYALILLGMWVFMYFVEFLGKGPTVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU42</accession>
    <name>R4VU42_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445604.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03795"/>
    <dbReference type="EnsemblBacteria" id="AGN00710">
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        <property type="gene ID" value="L593_03795"/>
    </dbReference>
    <dbReference type="GeneID" id="16180688"/>
    <dbReference type="KEGG" id="sali:L593_03795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.770"/>
    <dbReference type="eggNOG" id="arCOG03011">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209486_0_0_2"/>
    <dbReference type="OrthoDB" id="130128at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043902">
        <property type="entry name" value="DUF5786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19099">
        <property type="entry name" value="DUF5786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5786" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="60" mass="6654" checksum="B6835F230D3E48C3" modified="2013-07-24" version="1">MGFGSYDESEQSNQEIDTDLDEENVASGETDHDGDVEFEIGASNDELLDRLSDIKDQQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUC5</accession>
    <name>R4VUC5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445699.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04270"/>
    <dbReference type="EnsemblBacteria" id="AGN00805">
        <property type="protein sequence ID" value="AGN00805"/>
        <property type="gene ID" value="L593_04270"/>
    </dbReference>
    <dbReference type="GeneID" id="16180888"/>
    <dbReference type="KEGG" id="sali:L593_04270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.869"/>
    <dbReference type="eggNOG" id="arCOG02007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_2"/>
    <dbReference type="OrthoDB" id="12642at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="3">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="803" mass="86829" checksum="81353928E03C1D7A" modified="2013-07-24" version="1">MAEPTDRNRLDAEASPYLQQHADNPVNWQPWDDAALAAARERDVPIFLSVGYAACHWCHVMEEESFEDETVAETLNEKFVPIKVDREERPDLDSVYQTACQLVSGRGGWPLSAWLTPDGEPFYVGTYFPRESRQGMPGFLDLLEDVADSWADPEERKEFEQRASRITSHIREELEDTGEATRATSAAGTASSTDTDAASGLDDAGETEPSPLERAASAALRSADRDHDGWGQGPKFPQPARIEALFDAGWSADSVGGDAQEDSEFHAVANAALAAMVDGGLYDHVGGGFHRYCTDRDWTVPHFEKMLYDNAEIPRILLGAHQLMGHDRYATVARETFDFLDRELAHPDGAFAATLDARSAVPHNRTEDGQQGEQEEGEFYVWTPEEVAAVLDDSELTALVCDRFGITERGNFEGATVLTIDASIEDLAAEHDLDAATVRERLDAAREQLREAREDRPRPRRDDKVIAAWNGLAIRALAEGSLVLDDEGLAERALAALAAVREQLWDGERLARRYVPTVDEAAATGSETGAIVDVDVQGRGYLEDYAFLGRGALACYEATGDPEPLAFALDLGDAIVDAFYDDAAGTLYSTPAGGEDLIARPQEPRDQSTPSSLAVGTDLLLALDAFRSDHRFEEAARRVLRTHEDRLAERPLEHPSLALATERARAGSTEVTIAAGQGSGGEAPAGEAPAGKAPAAAASAGEVPPAGIPVSWRSWLAGRYLPRRLLAPRPPDAGGLHGWLDRLGLDDAPPIWAGRDAADGPTAYVCRAFTCSRPLTDPDAADSWLGSSGDTRPAGDSDPSHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUD8</accession>
    <name>R4VUD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04345"/>
    <dbReference type="EnsemblBacteria" id="AGN00820">
        <property type="protein sequence ID" value="AGN00820"/>
        <property type="gene ID" value="L593_04345"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04345"/>
    <dbReference type="eggNOG" id="arCOG00723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149106_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="16628" checksum="A61D12118CB8AB09" modified="2013-07-24" version="1">MGPVVTGTVHDTYVAAIRHDLVDLPEDARRIGVVRRPTSWFHGAVDENVPALGPPEDLLEDAKQREEDLKLQGICDDDAQNVAWDEVDFAERYRDYLETEEGSVAEDRLAELLREGTDVVLVCFENTEKKRCHRTILREVLEERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUE1</accession>
    <name>R4VUE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LemA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04370"/>
    <dbReference type="EnsemblBacteria" id="AGN00825">
        <property type="protein sequence ID" value="AGN00825"/>
        <property type="gene ID" value="L593_04370"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04370"/>
    <dbReference type="eggNOG" id="arCOG06218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870498_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="35044" checksum="A6CD74DEA1B5F4DF" modified="2013-07-24" version="1">MTIAPSTLLVDATAASTWVLQSGSEGSDDGELFLFLLIGFLGGLYLIYDGFDTWQLSRLVQDTPTSKVRSMSVGRVELEGTAHKRDASVTPPIADEECLYVDWKAEKRERRVDDDGNVHYEWVTIASGERTLAFDLEDDTGSVLIRADHDDPEFDINRDGHRREHTYHSGESAPDEVRRFVRAKGDPAAVATTPAASEEADGFLDDVADFASDLATDSLDDTGNRRRYSENVLPVGSHVYVFGSAEPREGATMETSEADLLAVSRDPGSDEFLVSDSTEEKLQDSYGTWGPIEVGGGLLLSAGCLFVLLWKYRLHELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUN4</accession>
    <name>R4VUN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445829.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04930"/>
    <dbReference type="EnsemblBacteria" id="AGN00935">
        <property type="protein sequence ID" value="AGN00935"/>
        <property type="gene ID" value="L593_04930"/>
    </dbReference>
    <dbReference type="GeneID" id="16181151"/>
    <dbReference type="KEGG" id="sali:L593_04930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1007"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062567_0_0_2"/>
    <dbReference type="OrthoDB" id="65802at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="41545" checksum="022D623E64D47164" modified="2013-07-24" version="1">MNLLVAATVGMLAVAAVPYVLYLGFYALIRPSGSPANKEAQEPTLSIVLPTFNEERIVEGKLERICSLDYPMDKVEVVVVDASDDETPDRIRDFFANRESPELTLIEEETRRGLALALNDAYAAASNEVVVKTDCDSEVADGALREAVANLADPHVAAVTGRNAEVLGGSDVESGYRGVQSYIQTLESHLDSTLIFHGPFSAFENDAIVPIDEDSIADDTELALKIRRGGQRVLFDPAIRYREAAHSAFRKRRKQKDRRAMGLLRLLVRNRDALGRYGRYGRVVLPFNWWFMIVSPWLLAATLLTGTVAGVSVFGPAGLVLPLAVGGFVFAGSRDMLGPLQALYAVFDTQVSLLRAAIKLLAGKGSAVWEIDSELREAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUX9</accession>
    <name>R4VUX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UpsA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445934.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01040">
        <property type="protein sequence ID" value="AGN01040"/>
        <property type="gene ID" value="L593_05455"/>
    </dbReference>
    <dbReference type="GeneID" id="16181361"/>
    <dbReference type="KEGG" id="sali:L593_05455"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_4_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15605" checksum="315BB76D8081480D" modified="2013-07-24" version="1">MQEHLLVPYDGSPLSQRALERALTKHPDDRITVLYVLDPVLAVYEAEAKGAPAASTLHDRMTERADEICADAAERASEHGREITKATENGRPARTIVSYADDHDVDHIVMGSHGREGVSRLVLGSVAERVMRQAPMPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ3</accession>
    <name>R4VUZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445954.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01060">
        <property type="protein sequence ID" value="AGN01060"/>
        <property type="gene ID" value="L593_05555"/>
    </dbReference>
    <dbReference type="GeneID" id="16181426"/>
    <dbReference type="KEGG" id="sali:L593_05555"/>
    <dbReference type="eggNOG" id="arCOG03860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060475_0_0_2"/>
    <dbReference type="OrthoDB" id="56787at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="32329" checksum="5C059EF7DAFE1F37" modified="2013-07-24" version="1">MDGSGGLDERYVSAFDVVRSPARVDILLALAEQASADPDAPALTFSTLHDRVDIDDSGQFNYHLDKLRGHLVRSTEDGYRLSPRGHEVAGAILSGAFAEGEDRGPEPLDGDCPHCGAPLEAAYEHGQIVVSCGDGHEIFTSSVPHDLATEESLADVLESVRARARYKLQIVLEGTCTYCYGDVEWSVDRDADGPAPVLYTGRCTRCGVGYSTPPTYAVFFHPAVVSFFWERGVDVREVVAWEIDDWTGEQRIVSESPFRVAVTFETEDARLTVTLDETATVVDAVEESLVVDEAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVQ8</accession>
    <name>R4VVQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid ABC transporter amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446179.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06690"/>
    <dbReference type="EnsemblBacteria" id="AGN01285">
        <property type="protein sequence ID" value="AGN01285"/>
        <property type="gene ID" value="L593_06690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181842"/>
    <dbReference type="KEGG" id="sali:L593_06690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1366"/>
    <dbReference type="eggNOG" id="arCOG01023">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604973_0_0_2"/>
    <dbReference type="OrthoDB" id="23746at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="71"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="483" mass="49986" checksum="1970E95B78F180AC" modified="2013-07-24" version="1">MADHYKRRDVLKATGGAATAASFGLAGCIAGDSDDDDDGGDGDDGGDTSGGGDDGGGSGDGGGGDETVSGTVKVGVIQPTSGDLQYYGLQSLWGFLSGLSYKADSAPPNVTSAGTTSIDVGDLTYELHIEDSQFAPDQAQSVATTLVEDEEVDVLFGTASSGSARRVIQNVAVPSSTPIVVGPAAAADITSNSDYCNEMVFRASENTAMDARSGGRYVAQETDVESVYIMAADYSFGRAVANNYTEVLEANGIEIAGTDFVPRGYSEFEGHFQNAVDAGADAVIGGFTVVTLPAFLSTGLAGGYGLRMFGGFATRITANAVGQVAANAIGEPLTAEKIQDAKLGPFTTRYHWNQYDNEINDWFVENYANVYGTLPDLFTSGTFTAASSIHQGVQASGSTSGADIAEAMRGMTVTDTPKGTDGYTYQEYNNQARSAMTVAYPVPTTDEWASNWDASIMPGEPIATVGADEVTLPADSDSMGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVW8</accession>
    <name>R4VVW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hflX</name>
        <name evidence="10" type="ORF">L593_02275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445300.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02275"/>
    <dbReference type="EnsemblBacteria" id="AGN00406">
        <property type="protein sequence ID" value="AGN00406"/>
        <property type="gene ID" value="L593_02275"/>
    </dbReference>
    <dbReference type="GeneID" id="16182861"/>
    <dbReference type="KEGG" id="sali:L593_02275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.461"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OrthoDB" id="33372at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="188"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="469" mass="51337" checksum="9BC2A5B11BF8688F" modified="2013-07-24" version="1">MQAIAVRRRRDEPIDATELRGLAETAGYEVIETVGQRRAEDSTYHVGRGKAEELADLAAETAADAILVDDRVTPQQAYHLEELCPPETRVLGRYRLVLEIFADRATDRAAQLQVELAELRYERKRVRAALKLEEDAANERRTLGEFEASEQGEIKHVDERIEALESALESTQVVVEQRRERRSEQGFDHVAVAGYTNAGKSTLLRRLADDEAMTHGSRGANDDPSAPSGDPIVASEDQSAANDDPTAANDANSKHDDLAERVTVEDRLFETLETTTRRATIEGRRVLLTDTVGVVSDLPHWLVRSFRSTLRAVGTADAVLLVLDASAPVDRFETRLATAIETLTGRTDAPVLPVLNKVDATDEGTVAERREQVRERLPETEPIAISALAGSGIDTLGRRLDDALPAERVELTLPNCSATMGLVSKAYDELSVADVSYEGDTVELLANGHPAAVERLRGQAEELPESPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW93</accession>
    <name>R4VW93_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Citrate synthase</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445435.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02950"/>
    <dbReference type="EnsemblBacteria" id="AGN00541">
        <property type="protein sequence ID" value="AGN00541"/>
        <property type="gene ID" value="L593_02950"/>
    </dbReference>
    <dbReference type="GeneID" id="16180480"/>
    <dbReference type="KEGG" id="sali:L593_02950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.597"/>
    <dbReference type="eggNOG" id="arCOG04237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_2"/>
    <dbReference type="OrthoDB" id="39666at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="377" mass="41283" checksum="82273EC70EE9FBD9" modified="2013-07-24" version="1">MADSDVARGLEGITVAETRLSDIDGEQGELVIGGFPLGELAGNATYEETLFLLFEDRLPDAEELEDFRADLAGRREISDEVRAVLRQAAEQDKPAMDALRMGAAAANLDQGEEDPEADAKRVIAIFPTIVATYWRYRQGEEPVEPREDLRHAANYLYMLDGEVPDEAEARGLETYLNTVVDHGLNASTFSARVVVSTESDVVSAATAAVGTLKGPLHGGAPGPVLEDLQAVYESGDPEGYVQQKLENGERIMGFGHRVYRVRDPRAAVLSSAAEQFYQDGGDAAFFEAAEEYEEVAVAALEEHKPDRRLETNVEFYTAALLHGVGIPRQLFTATFGISRSGGWMAHCLEQLEDNRLIRPSSNYVGDSGRTWTPVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWD1</accession>
    <name>R4VWD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445480.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03175"/>
    <dbReference type="EnsemblBacteria" id="AGN00586">
        <property type="protein sequence ID" value="AGN00586"/>
        <property type="gene ID" value="L593_03175"/>
    </dbReference>
    <dbReference type="GeneID" id="16180373"/>
    <dbReference type="KEGG" id="sali:L593_03175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.642"/>
    <dbReference type="eggNOG" id="arCOG10779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020557_2_0_2"/>
    <dbReference type="OrthoDB" id="24988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="499" mass="55757" checksum="0510B94D1C963419" modified="2013-07-24" version="1">MFAGPEDYWLVRFLLQRGLALLYLLAFLVAATQFRPLAGEDGILPLDRYVEHAEFAERPSLFYYVPSDRAIGIAAWSGVALSAVALLAGPYWLAVWLPGWTAIPASMALWLLLWGLYLSFVNAGQLFYGYGWESMLLETGFLAVFLGAGPAGPPVVVVWLVKWVCFRNMFGAGLIKLRGDECWRDLTAMDYHYETQPIPNPVSWFAHHLPDRFHRVEVLGNHVVELAVPFLLFAPQPYASLGGAAIVGFQAWLMLTGNFSWLNALTIVQAVAAFTDSVLAAAFVPVGTITAALPAGPSAVGAAPSPLIPLQIAAVALALVVAFLSVRPVQNMLSERQVMNTAYDPLSLVNTYGAFGSITRDRHELVIQGTTDERITEDTEWQTYEFQGKPTDVSQRPRQVAPYHLRLDWQLWFAAMRRTPRRVPWFTRFLGKLLAADEATLALLETDPFDGDAPTYVRVERYRYRYTTPEERAETGDWWVRNQVNTYVPPVAVEELQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX18</accession>
    <name>R4VX18_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_09075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446654.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09075"/>
    <dbReference type="EnsemblBacteria" id="AGN01760">
        <property type="protein sequence ID" value="AGN01760"/>
        <property type="gene ID" value="L593_09075"/>
    </dbReference>
    <dbReference type="GeneID" id="16182613"/>
    <dbReference type="KEGG" id="sali:L593_09075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1861"/>
    <dbReference type="eggNOG" id="arCOG00976">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_2"/>
    <dbReference type="OrthoDB" id="54045at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="26338" checksum="AEA579BEC0E680A6" modified="2013-07-24" version="1">MEPAVLRDDMVDSLEHESKGVVRSDRVGLAMREVPRHEFVDDEQGAYADAAQRSHGTRVLAPSTVARLIEALAPEPGDEVLVVGAGVGYTAAVLAEVVGARHVHAIDITRQLVFEARSNLATAGYSEVLVDCRDGAEGLAEYAPFDRILVEAAAVEPPRALVRQLADDGQLVMPLGAGQQSLTIVHADGEREPLGGVAFAPLLVEGEQAGAVERNRTAREERERADRQAQRRAGWEHDWIDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX30</accession>
    <name>R4VX30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446669.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09150"/>
    <dbReference type="EnsemblBacteria" id="AGN01775">
        <property type="protein sequence ID" value="AGN01775"/>
        <property type="gene ID" value="L593_09150"/>
    </dbReference>
    <dbReference type="GeneID" id="16182632"/>
    <dbReference type="KEGG" id="sali:L593_09150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1877"/>
    <dbReference type="eggNOG" id="arCOG04633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135995_0_0_2"/>
    <dbReference type="OrthoDB" id="109158at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14127" checksum="D3BBE941E1C1F9D5" modified="2013-07-24" version="1">MSLDTMQPTPTWDPDSHEATVETFEAIADEITVKVWGGDWCKDCRAALPDFAAALDAAGVPEASIEQYPVEKAEDGSKVGPGVEDYGIEYIPTIVVERDGEELVRFVESEDVPAAIWLADRLRESEQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX62</accession>
    <name>R4VX62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446709.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09350"/>
    <dbReference type="EnsemblBacteria" id="AGN01815">
        <property type="protein sequence ID" value="AGN01815"/>
        <property type="gene ID" value="L593_09350"/>
    </dbReference>
    <dbReference type="GeneID" id="16182726"/>
    <dbReference type="KEGG" id="sali:L593_09350"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307868_0_0_2"/>
    <dbReference type="OrthoDB" id="62109at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="22584" checksum="29DD1E84E448D382" modified="2013-07-24" version="1">MAQQAEPVIERSLRTLTETATECVATLPTVVHCYAEEDPARSDVVERVGTLESRCDEQVQSLRREIATVGPEFSDAYLFAPDLLGLAYEIDRIAGASEQFATELAAIQPRLPAAAEQSMIEHARRSTAAGDRLRRGVDAALDDEPCGEDVDAIRAAESACDRLKYEMLADANGSPGEVLVVRQFAVTLDAIPNAVEDAADRLGQLRAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX76</accession>
    <name>R4VX76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445760.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04585"/>
    <dbReference type="EnsemblBacteria" id="AGN00866">
        <property type="protein sequence ID" value="AGN00866"/>
        <property type="gene ID" value="L593_04585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181224"/>
    <dbReference type="KEGG" id="sali:L593_04585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.936"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_3_1_2"/>
    <dbReference type="OrthoDB" id="85871at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="26847" checksum="FC02056394AFD435" modified="2013-07-24" version="1">MYAVDLHTHTRFFHGFEARSTAFDPVGARLLTALAKRRGLDALAVTNHDYSWLPTGHPHARRAGAHQGSDVRLDGGTAARGPDQPDEFLTLPGIEISTTRGHLLVVGPDPPAFTEPGTLAPDEAIDLAHERGCAAIIPHPFRASTVRETDATADAVEVNGKHTHHKERVALLAEERDCPIVGGSDAHYPVEVGRSYTRVDAEELTPESVVDAIRDGRVEPAVREYRLDRVLTPVYSAIHRLKGDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXG5</accession>
    <name>R4VXG5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="5" type="ORF">L593_05010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445845.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05010"/>
    <dbReference type="EnsemblBacteria" id="AGN00951">
        <property type="protein sequence ID" value="AGN00951"/>
        <property type="gene ID" value="L593_05010"/>
    </dbReference>
    <dbReference type="GeneID" id="16181187"/>
    <dbReference type="KEGG" id="sali:L593_05010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1021"/>
    <dbReference type="eggNOG" id="arCOG04108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OrthoDB" id="129447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6439" checksum="6BEDD5E6BCE24971" modified="2013-07-24" version="1">MAGDFIRVECPDCENEQVIFGKAASDVVCAVCGHTLATPTGGLATLESDVVEVVESRQADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXV7</accession>
    <name>R4VXV7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamine synthetase</fullName>
            <ecNumber evidence="2 6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445995.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05760"/>
    <dbReference type="EnsemblBacteria" id="AGN01101">
        <property type="protein sequence ID" value="AGN01101"/>
        <property type="gene ID" value="L593_05760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181420"/>
    <dbReference type="KEGG" id="sali:L593_05760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1179"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_2"/>
    <dbReference type="OrthoDB" id="47310at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="111"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="49696" checksum="BA17112B7C59849E" modified="2013-07-24" version="1">MTTDTLTAEEEAVLEEIEEEGIDFLRLQFTDILGTVKNVSIPASQAEKAFEEGIYFDGSSIEGFVRIQESDMRLDPDPSTFAILPWRESEDGAAGRLICDIVDTSTGEPFVGDPRTVLKSALDDAAELGYSLNVGPEPEFFVFEQDEDGRATTTTHDAGGYFDLAPKDLASDLRREMIYNLEEMDFDVEASHHEVAEGQHEIAFKYDDGLSTADNIATFRAVVRATAQKHGVHATFMPKPIAHINGSGMHSHLSLFEDGENAFHDADDEFNLSETAKQFVAGILEHAPAITAICNPTVNSYKRLVPGYEAPVYVAWSDVNRSALIRKPAARTPAASRIELRSPDPSCNPYLALAVMLQAGLDGIERDLEAPDPVRENIYEFDEAKREDYGIETLPANLGQAVDALEADDVITDALGPHVSEKFVQAKRAEYAEYVAEVTEWETDRYLETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXX5</accession>
    <name>R4VXX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_05835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446010.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05835"/>
    <dbReference type="EnsemblBacteria" id="AGN01116">
        <property type="protein sequence ID" value="AGN01116"/>
        <property type="gene ID" value="L593_05835"/>
    </dbReference>
    <dbReference type="GeneID" id="16181507"/>
    <dbReference type="KEGG" id="sali:L593_05835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1195"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="25719at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="374" mass="41636" checksum="A20B1C1C5A45E862" modified="2013-07-24" version="1">MSVENTRQTGDEALISLEDVEVHFEESQGIFDFSDPDVVRAVDGVSLDIFEEDVVALVGESGCGKTTLGKTCIGLQRPTGGSVKYRGQDIWDAKDGKGDVEIPYKDIRRSLQIIHQDPGSSLNPNRRVMKILEAPLKRWQSQMSAGDRRGQVLAMLEEVGMTPPDDYAGRYPHQLSGGEKQRVALVRALLMDPDLILADEAVSALDVSLRVEMMDLMLDLQDKFDTSFVFVSHDLSNARYFAAHSGGRIGVMYLGELVEIGPAEKIINNPQHPYTKVLRWATPDLAPGSQGSEKPPVRKIDIPDPQNPPPGCRFHTRCPEARQVCMEQTPPEYSTEELHETKCFREDDSHEYWSSPQITDDSDETSGLYSEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY28</accession>
    <name>R4VY28_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase I</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_06060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446055.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06060"/>
    <dbReference type="EnsemblBacteria" id="AGN01161">
        <property type="protein sequence ID" value="AGN01161"/>
        <property type="gene ID" value="L593_06060"/>
    </dbReference>
    <dbReference type="GeneID" id="16181623"/>
    <dbReference type="KEGG" id="sali:L593_06060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1241"/>
    <dbReference type="eggNOG" id="arCOG04542">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_2"/>
    <dbReference type="OrthoDB" id="84114at2157"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="4">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="22662" checksum="38DFA400495C5E80" modified="2013-07-24" version="1">MTDNQLQYEETTADPVEDSEIDLEKARRGTRLLLEAIGEEPEKAPLAETWDRRVPAMMETLTEGTRETAKPDLRTFGADTDELVVKTEIPIYSLCEHHMLPFFGVAHIGYRPGEEIVGLSKLPRYVRWQSRRLATQEGLTADIAEGLQDELDPESVIVEVSATHLCEAMRGVETRTETTSRATAGDPNDCDRTQFDNVLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYB1</accession>
    <name>R4VYB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447134.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11485"/>
    <dbReference type="EnsemblBacteria" id="AGN02240">
        <property type="protein sequence ID" value="AGN02240"/>
        <property type="gene ID" value="L593_11485"/>
    </dbReference>
    <dbReference type="GeneID" id="16181996"/>
    <dbReference type="KEGG" id="sali:L593_11485"/>
    <dbReference type="eggNOG" id="arCOG05861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392152_0_0_2"/>
    <dbReference type="OrthoDB" id="102661at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="703" mass="75406" checksum="C0080710EFA0CA9C" modified="2013-07-24" version="1">MTDDDTTIELSRRTVLGGLGGIGVAATGAALGTSAYFTDDEAFEGNSLAAGSLDLKVDWQEWYNGTKIEAYPDPDNDGVQDAFASEPGQTTAKGVGYVCEDGADTPADLDPEHSLRTTVSGETFGSGPPLPLVHLTDLKPGDCGGLTLSFHLCDNPGFVWMNGTLTENAENDVTEPESAVDDSDGQGELADAIRTRLWYDADCDGERDDGEVPITPELSLAELLGVLGSDHGIPLDGALGDDGATIAQAPSLGPGTCPETPYDEVTTGTEEFPNGTTRQRMNPKCSDFGLVEAVRIGSDEPGGPLPAPGACATYETDYGDVRVCRDADGTITSWETDDSPDGSFDASGDGFCVSKVVVKGGNQGANIYHYDRDADPVERSSGDEGSFVTPTGQDYSHVSVCVDLVAEDGNGDDGRDCFENSTTHCVGLEWWLPVDRGNELQTDSVGFDVGFYAEQCRHNDDPPQTQRIELGKDAARNTGFEAVSDGGYFGSGYWKDDPTQTNQDGGTYEQLYLTFDQSFGPYYVSALAPFTIGDIQSIRYRTNTPSGVSQNYFLEIYTSPDGSNDDASWYGRLLQALPGDALNRTVSPDTWVTWRTESGTNQLTFYDHNHDYDTTDSTPGDAPNAYLGQDTGVTLADLQSTDAFDWSNYVSDADSTPKNYRDEEVRALRFATGSAWEDDHEGCLDAIEITLEDGRSAVVDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYD2</accession>
    <name>R4VYD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447159.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11610"/>
    <dbReference type="EnsemblBacteria" id="AGN02265">
        <property type="protein sequence ID" value="AGN02265"/>
        <property type="gene ID" value="L593_11610"/>
    </dbReference>
    <dbReference type="GeneID" id="16180413"/>
    <dbReference type="KEGG" id="sali:L593_11610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2393"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="248"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="386" mass="39690" checksum="98029E830665C3DD" modified="2013-07-24" version="1">MVRIVGVGLTPFGTTPERTGRAMFAEASEEAFADAGVPRGDVEALYYGNFMGELAEHQGHQGPLMAEAAGIQAPATRYETACASSGAAVRSAVQTLRNGEADLLLVGGAERMTNLGTGGATEALAIAADDLYEVRAGVTFPGAYALMANAYFEAFGGSREDLAEIAVKNHENALENEYAQYQKRIDVDTVLEAPMVSAPLGLYDACPITDGASALLLASDEYAERNDLDAPVTITGSGQGGDNLALQDREHLARSPAADEAAAEAYEDAGIGPDDVGVAEVHDCFTIAEVLALESLGFYEPGEGIGAARRGETTATGDRPINLSGGLKAKGHPVGATGAAQIAELAQLLRGDHVNSDAVADVDVGVAHNAGGTVASAFVHVVEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYF6</accession>
    <name>R4VYF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01256">
        <property type="protein sequence ID" value="AGN01256"/>
        <property type="gene ID" value="L593_06545"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1335"/>
    <dbReference type="eggNOG" id="arCOG04907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101661_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040493">
        <property type="entry name" value="DUF5518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17647">
        <property type="entry name" value="DUF5518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="24245" checksum="2281E1C968E50C87" modified="2013-07-24" version="1">MDRTSVRPVPAVVDWLVGALLIIVGFAFTLGGGALFTVIDRSEIREALVDAETDPDPLTLQELVDVSATTGTWSSVGLIVFGVLVVLVGLGYVFRRGRARRRAKAGEAVSSYGANALLGAIVAVVLSFVPFSQVLGGIVAGYLERATSPRDVSAGALSGFLTVVPLLFVSIFVLVGGVIGLLDIGEAGLALAASAGLLLSLAIVATLSAALGAIGGWLGGKLRGTGTRREVSEPGTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYL6</accession>
    <name>R4VYL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagella assembly protein j</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_06895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06895"/>
    <dbReference type="EnsemblBacteria" id="AGN01326">
        <property type="protein sequence ID" value="AGN01326"/>
        <property type="gene ID" value="L593_06895"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1409"/>
    <dbReference type="eggNOG" id="arCOG01810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428035_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="208"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="473"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="686" mass="72175" checksum="0A53913D0C607ADF" modified="2013-07-24" version="1">MTQPHDGQSAPAAEGGAAPAHADGATPLRDGGSAPSREADATAGPALTDGGVGEPSDAVNAAHAAAATEAEDATTDDVGLSVLDRALYALFSRHADSGRHDADRSTYRGTDVTTSFGVYVARLYGLSWIAFLAVVGLATVVVAALLPGQITTTQQALPTGGRGVAAVVLALPAGALAKRGSLRLGGRYLTMRAAARTSNIERTLPGAVRYLRVLSTGSDDLRGMLRKVARNDEAYGHTAVAFRTALNKATLTGSLGEGLRIVARDTPSRDTLAPFLLKFREHASQGQEELTSYLRMEARMLSHRQSRARERRQDFLELLAELFIVMLVLPALLVIVVSVLSVLSSGLSGTVSTPLGSITLRALVIYSSAVLVLLVGLGASMAVQSLRPPGQTRRYRRPDTMAETLATATTNPACTVVFAIPLAIWVGALLLFAGLSPLNAGLLAYAAGTIPVGVVSVRRSRIDDAKDREIKDFVHAVSGHVALGRPFSQAVAVVAKEVDLGPLDPDVADLAFNSRLTTHDGDLRTEALDRFVERVGTPLAEQTIGLVTGALDSGGDVEDVFDALQTEIGRLHHEKQALRSSMQVYVAVGWTTALLIVGITIAVNAYVIDGFTQLSAVSAADGSIGFSANAVDLDAMRFRFYVVTQCTLVSCGWFAGVANRGRYEGMLHSGLLVLLGYLIFRGVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYL8</accession>
    <name>R4VYL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12060"/>
    <dbReference type="EnsemblBacteria" id="AGN02355">
        <property type="protein sequence ID" value="AGN02355"/>
        <property type="gene ID" value="L593_12060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180006"/>
    <dbReference type="KEGG" id="sali:L593_12060"/>
    <dbReference type="eggNOG" id="arCOG04658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159741_0_0_2"/>
    <dbReference type="OrthoDB" id="120406at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16227" checksum="48A56C3CA8E608D8" modified="2013-07-24" version="1">MVQERLTDGYRIGELLASEIDGRRSGLLAPLAVANADRTVEGTPDGERAYDVRLLEGDRDPRREPTPGDAGELFARVFVHETGATLVLDATRPDARDAAVAADLEVDPEWRTGGLAVRLAYGAQVKRAVDVLEAAVAERVTSGDAADADTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYN0</accession>
    <name>R4VYN0_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_06970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06970"/>
    <dbReference type="EnsemblBacteria" id="AGN01341">
        <property type="protein sequence ID" value="AGN01341"/>
        <property type="gene ID" value="L593_06970"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_06970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1424"/>
    <dbReference type="eggNOG" id="arCOG03499">
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="PKD/Chitinase_dom"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="28067" checksum="FD26C6A3C8917DF2" modified="2013-07-24" version="1">MNVTVDRTPPTVATVRGNRTVDEDTAVAFDGTNSTDGVGVANYSWVFGDGATATGETVSHAFADPGTYTVTLTATDVAGNANATNLTVTVEDVPENTGGGGFRPLPDTTDPTADAGRDRTVTTGTAFSFDGTNSTDDVEITAYLWDVDGDGATELTGPEPTYRFQNSGTYDVTLTVSDRNGNTDSDDVAVVVEPADGTGSDGGSDGESDDDGSGPGDGDGSDESDTDGGTEVDADDGASEDGTDDSETGGGADDGSPGFGVAVALVGVVLGTAVVRRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYX1</accession>
    <name>R4VYX1_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_12605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447354.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12605"/>
    <dbReference type="EnsemblBacteria" id="AGN02460">
        <property type="protein sequence ID" value="AGN02460"/>
        <property type="gene ID" value="L593_12605"/>
    </dbReference>
    <dbReference type="GeneID" id="16180078"/>
    <dbReference type="KEGG" id="sali:L593_12605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2587"/>
    <dbReference type="eggNOG" id="arCOG04588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104913_0_0_2"/>
    <dbReference type="OrthoDB" id="93321at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043815">
        <property type="entry name" value="DUF5797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19110">
        <property type="entry name" value="DUF5797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="166" mass="18412" checksum="DC76A93ADB0E0B25" modified="2013-07-24" version="1">MTLSEEAHSRLADVVELQPTKNSELQDRWGMDSGSDVHSYLTGQLADYTFRDDNSLIRATSEAADLVDVEPGVEPGEDGDGVGTVRVTALQADVIEVLPGPDERSKSVVAVLQALREHTDRDPEVDEVRSALQRLRRQEAVEVEYRSVPTFRLAVPREDLTVEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ49</accession>
    <name>R4VZ49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/Ca2+-antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_13030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447439.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13030"/>
    <dbReference type="EnsemblBacteria" id="AGN02545">
        <property type="protein sequence ID" value="AGN02545"/>
        <property type="gene ID" value="L593_13030"/>
    </dbReference>
    <dbReference type="GeneID" id="16180349"/>
    <dbReference type="KEGG" id="sali:L593_13030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2671"/>
    <dbReference type="eggNOG" id="arCOG02881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_0_2"/>
    <dbReference type="OrthoDB" id="43312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="195"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="35860" checksum="6433093E725FD272" modified="2013-07-24" version="1">MVISGIVPDVTPVHLVVIAIASVAVWIGSAWLETSAEDLSAYYGLPPVVQGSVVVAVGSSFPEFASVVIAAFAGAFDLGVGAIVGSALFNVLVIPALSGLSTEGEELDANRAIVYKEAQFYMIAVSALIITFALAVIYEPVESADALSGEITRPLAVIPLLLYGLYLFIQWQDVGDHTPGDEGEGVDVLPAWGKLAAGLLVILVAVEFLVGSVEFLGAALGVPEFLAGVTILAAATSLPDTLVSVRSASGGNGTTSLGNVLGSNTFDLLVAIPVGVVLVGSLTINFAVALPLFGVLTLATVLLFTFLRTDLTLYRWESYLLLLAYAVFVAWMVTESIGATDLLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ73</accession>
    <name>R4VZ73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447464.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13155"/>
    <dbReference type="EnsemblBacteria" id="AGN02570">
        <property type="protein sequence ID" value="AGN02570"/>
        <property type="gene ID" value="L593_13155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180378"/>
    <dbReference type="KEGG" id="sali:L593_13155"/>
    <dbReference type="eggNOG" id="arCOG03162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_7_0_2"/>
    <dbReference type="OrthoDB" id="74526at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="4">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="216" mass="24349" checksum="67AD98DEFB36EB58" modified="2013-07-24" version="1">MPTALYVRVSTEEQNLERQLDSTHDYAENDLGQPLSNLDVYRDKSTGTDTARSGYKELMQAVEAGEVDHVVVHEISRLARSLQDLERTVSRVTDNGAAVHFVRDGLSFGDGKERPMHRLQMQMLGAFAEWQARVKQMNTKEGIAARQQEDGYHHGRPPLGFEKDEGQLIEGSNYDRVCAVLDMVQKGELSKRKAAGELNTSRKTITRALDRSELYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZA6</accession>
    <name>R4VZA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13355"/>
    <dbReference type="EnsemblBacteria" id="AGN02610">
        <property type="protein sequence ID" value="AGN02610"/>
        <property type="gene ID" value="L593_13355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2732"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="219"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="596" mass="67425" checksum="6F0A298064DA8710" modified="2013-07-24" version="1">MAGTPDHPESAPDEARAEQRDAASDRGAQRGAAADHGGSDTTVTTAEEPPQSNDTSSLTGEFEASFAYVRRQLLRAGQLLQGSTIPTDEYSPSEHGPLVSFDGLDGYEEVDRYWVNAPFAFVSINYDDAANEYRYEIVEPELTDDEFALLETAIEDVRDPLIYRTDIDVDDAETVLRDELREQLEQYGADLSVGSFHKLLYYVYRAFRGYGKIDPILHDPHIEDISCDGYDLPIFVYHDDYTDVESSVSFAKEELDNFVVRLAQQSGRHISIGDPMVQTTLPDGSRVEMALGEEVTPRGSAFTIRKYAEDPFTPIDLLNYGTFNVEQMAYLWLAIEHNKSLIFAGGTASGKTTSMNAISMFIPPRSKVLTIEDTRELTLYHDNWLSNVTRERLHEGTDIEMYDLLRSALRHRPEYIIVGEVRGDEAITLFQAMNTGHTTYSTMHADSVQTVINRLENEPINVPRSMVQSLDVLCVQTLTRFEDERVRRNKTVAEIEGIDQRTGELDYSTAYRWDADDDSFSGSGSAVMGEIREERGWTQSEYLSERRDRQQFLEYLRDNDVTDYRQFTALVNEYYADKDAVMERVSGTGDHPVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZK2</accession>
    <name>R4VZK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RecA-superfamily ATPase implicated in signal transduction-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446570.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08655"/>
    <dbReference type="EnsemblBacteria" id="AGN01676">
        <property type="protein sequence ID" value="AGN01676"/>
        <property type="gene ID" value="L593_08655"/>
    </dbReference>
    <dbReference type="GeneID" id="16182498"/>
    <dbReference type="KEGG" id="sali:L593_08655"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637160_0_0_2"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="430" mass="45736" checksum="26417F241C79388F" modified="2013-07-24" version="1">MSDESAPSYCDFCRLPRPAGTIEAEIGGERYVFCSTHCRDAMASADRVFTRYHGHRRFSPGVEAIDAVLPQGCPRNAFLLCSAQAGTRVGALQAELVWRALQRDEPAVLVTFQEPPSSVVERFVTLDWNVLPYLESGQLRFVDCFSYRMADHGEPHGAVSPWNTHLATAVAPATERVRDPTDADEIANKLETVLDGDGGAAAKLQRGASAADPGREPMVETGIVVIDSLTEFGSLVQPVQAYDFVKDLRADVCKARFVPVFAGATYGGDAGAFPHDLAYVADGLIDCKLDGEIVADGLVKRMRVRKLDGVLSYQRWIAYEFTAGRGLVPFDPEAQIERAGADAEASDAESEETGTDEGDANDETEESDAADGGGNGDDGSGADGEGGDDDGESGEDVPDGTDDRANAEAGGPASEQSTVSGEDRDDQSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZQ3</accession>
    <name>R4VZQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447624.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13955"/>
    <dbReference type="EnsemblBacteria" id="AGN02730">
        <property type="protein sequence ID" value="AGN02730"/>
        <property type="gene ID" value="L593_13955"/>
    </dbReference>
    <dbReference type="GeneID" id="16180974"/>
    <dbReference type="KEGG" id="sali:L593_13955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2855"/>
    <dbReference type="eggNOG" id="arCOG04692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082635_0_0_2"/>
    <dbReference type="OrthoDB" id="46460at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006438">
        <property type="entry name" value="HAD-SF_TIGR01548"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01548">
        <property type="entry name" value="HAD-SF-IA-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="31798" checksum="26B03E80E81800D2" modified="2013-07-24" version="1">MQVDAIVLDVDGVLVDVADSYRRAVVETVTHLEGTRFERDVIQPFKDAGGFNNDWELTDALLLYAIAQDAGYDVEVEAFTDAIAEAGGGLDGARAVLRDALGEESATDVESQWDPDAVRDAFQLRYLGAELYREIEGEEPERELRGYIHDEPVLIEPETIEWLEERFPIGVLTGRPAAEADIALDRVGLDVPDDHRFTMDDWEAGKPDPHALRTLAERFDATEVAFVGDTLDDVRTATNAAAADPSRTYHGIGVLTGGLTGEAGRQKYEEAGSSTVVDDVNGLRTLLAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZX8</accession>
    <name>R4VZX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02810">
        <property type="protein sequence ID" value="AGN02810"/>
        <property type="gene ID" value="L593_14355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14355"/>
    <dbReference type="eggNOG" id="ENOG502N5EW">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115579_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="12047" checksum="49B07406FE7A2988" modified="2013-07-24" version="1">MVGVSTGLSRYGVEAPTVVRAPTTDADGLKICPECGAPIGGTLGTQRIAHPTIRDDLEADELVTHGYRCNRHPSWVVLPSHPNELPDGWASVEIDLADGRSRPVPVPQAEVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0U1</accession>
    <name>R4W0U1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ORF">L593_11155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447070.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11155"/>
    <dbReference type="EnsemblBacteria" id="AGN02176">
        <property type="protein sequence ID" value="AGN02176"/>
        <property type="gene ID" value="L593_11155"/>
    </dbReference>
    <dbReference type="GeneID" id="16180061"/>
    <dbReference type="KEGG" id="sali:L593_11155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2301"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OrthoDB" id="91632at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_L14P_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="132" mass="14298" checksum="7C62DFA0E80FF48F" modified="2013-07-24" version="1">MEALNADVTQGLEKGSIVTCADNTGARELKVISTHGYSGTKNRHPKAGLGDKITVSVTKGTPEMRRQVLEAVVVRQRKSIRRPDGQRVKFEDNAAVIIDENEEPRGTEIKGPVAREVAERFGTIASAATMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W191</accession>
    <name>R4W191_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella biogenesis protein FlaI (Probable flagellin secretion system protein FlaI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447235.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11990"/>
    <dbReference type="EnsemblBacteria" id="AGN02341">
        <property type="protein sequence ID" value="AGN02341"/>
        <property type="gene ID" value="L593_11990"/>
    </dbReference>
    <dbReference type="GeneID" id="16182249"/>
    <dbReference type="KEGG" id="sali:L593_11990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2467"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="173"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="555" mass="62690" checksum="E0D51648750A9413" modified="2013-07-24" version="1">MADHGTKQITPELRKVAGRRPHLAQHLKEFKRITGEFPELIEEPTGEYETHRPNVLYPVGGPIYCHVYGDLGRDTKYYAIEPTLDDTELGLYNDVRRRLLERSATKPAPETEEEYDQRIDQLLSETVAIEGREVGTIDQLVDRISGGPKTVDRKTYENIRYQLTRDIVGFGPLEPVMRDPANEDIHVIGPQQCFVDHDTFGMLETTVEWGSNEEFDNWLRNMGERIGDPLSDSDPIVDSTLPDGSRINIIYSDDVSIQGSSLTIRQGEEVPLSVLQITKWGTLSPELAAYLWLCLENEQTVFVVGETASGKTTTLNSIMSFIPADSKIYTAEDTAEVLPPHDTWQQLLTREGGDGNSDVDMFDLVAAALRSRPDYIIVGEVRGEEGRMAFQAAQTGHPVMLTFHASDIVSMIQRFTGDPINVPETFMDNADVALFQNRVKQGDDVLRRVTSVQEIEGYSKEMDGVVTRQSFYWDPASDEIVFQGMNNSFVLEEQIATLLGYEDTREIYDELQFRADLIRRMIEENVLGYHEVNEAIADFQRDGIEGLPFDMARTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1B4</accession>
    <name>R4W1B4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12165"/>
    <dbReference type="EnsemblBacteria" id="AGN02376">
        <property type="protein sequence ID" value="AGN02376"/>
        <property type="gene ID" value="L593_12165"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2503"/>
    <dbReference type="eggNOG" id="arCOG04373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9399" checksum="1029D9908BE8BF62" modified="2013-07-24" version="1">MAADVADAVDALEAFDVEYETTPMGTVVETDDVGELMDAVEAAHRAVDADRVSTFLKIDDKRTATSSAADKVERVEAHLGREARSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1K1</accession>
    <name>R4W1K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12785"/>
    <dbReference type="EnsemblBacteria" id="AGN02496">
        <property type="protein sequence ID" value="AGN02496"/>
        <property type="gene ID" value="L593_12785"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12785"/>
    <dbReference type="eggNOG" id="arCOG04664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357894_0_0_2"/>
    <dbReference type="OrthoDB" id="115001at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="21692" checksum="3454413422160880" modified="2013-07-24" version="1">MMLPTHVLAGLAIALPIATIAPELAPAAFAGAAAGSVLPDLDMYAGHRRTLHFPVYYLPLTSVAAILALAVPMGATVGLAYLFAGAALHCRMDEFGGSLELRPWAERSERGVYDHYNDEWRAPRRLIQYDGSPGDLAMTGLLALPLLVLTGEPVNWLVIAAMLVGITYAVLRKWLADVVEQVIALTPRSIVAYLPGRYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1K4</accession>
    <name>R4W1K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12810"/>
    <dbReference type="EnsemblBacteria" id="AGN02501">
        <property type="protein sequence ID" value="AGN02501"/>
        <property type="gene ID" value="L593_12810"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2628"/>
    <dbReference type="eggNOG" id="arCOG02817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41572" checksum="4F005757C83B2F50" modified="2013-07-24" version="1">MGVLNVSEESPYDPSVYDDPGEAATYVDEELIGEGADIVDVGLESANKRYDVLSTEEELDRLDVAVEAMESTSGDAVFSIETRYAEVAEAAIDRGFDVVNDICGFADPRMPDVCAEYDVAVAKMASPPDLERPGAVDDTDWAERRSQEWFEQSDYVDRVYEALKQNGLTDKTIVDPAFGGWSERKTLRDDRETFRRLREFRALGRPILVSINRKNFLRTIADRSTEDALPVSLAATAMAIERGADVIRTHDVAETSDAAKIADAFDDDPATAAAGDVTVARLDVRTEREARRYLDEADGDLALGPAAVCTVLAIEGLDSSARTLLETEARSADVLMTGDRQTLVGGSYQEISALSARIADSDGLERLSKAIQALPTLRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1T5</accession>
    <name>R4W1T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13410"/>
    <dbReference type="EnsemblBacteria" id="AGN02621">
        <property type="protein sequence ID" value="AGN02621"/>
        <property type="gene ID" value="L593_13410"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13410"/>
    <dbReference type="eggNOG" id="arCOG07588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1109538_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="27480" checksum="57F78CD3E1E16831" modified="2013-07-24" version="1">MPTPSIDVYRVVLTDSATDNDVAAARGGPGALLQYEDREAAAAAAERYSDDGDVPVRLQAPAPQDPRDVDAYLVANPERRVRRPTGSIDDGLAFETSASQYGALGEALLTSHEQDPPVLLAYARRTLDGDQDRDPAVQLETDPDPVTFRSQETGDTATWLPDCAATVTVGGAIERRLLCEVKTGNGSTERDQRRVMQWAASERDREVLLVRLDVEALPDEYTARIQEIEPQEPDREWIDDDADLTLGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2B5</accession>
    <name>R4W2B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14335"/>
    <dbReference type="EnsemblBacteria" id="AGN02806">
        <property type="protein sequence ID" value="AGN02806"/>
        <property type="gene ID" value="L593_14335"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2935"/>
    <dbReference type="eggNOG" id="arCOG04599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067490_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043812">
        <property type="entry name" value="DUF5794"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19107">
        <property type="entry name" value="DUF5794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="32087" checksum="6190EDA67CD227C9" modified="2013-07-24" version="1">MSVSRHPIALRIEALVGRRAALLATVMCLPLVDGIFPALIVAGALDTVAGIVQVGLLIFGGSATVAVILADFDGSAREGAKTVALVAVPLLALAAIEAAFAPAIAGALDMIVFHRFAALVVIAVAASTASARIAEYVPRPAIVIVLGLVASVDPSNANLAATAEPALVVRAMAAALVGVGFAFLLAVTSPTLRRVVDLDRFRFGSAVALGLLGVGLLPGAQEIGFISDLAPLVVLALSALFAFDPDGDLGRWTRIPDERSRVRDTVIGDGGESELSVDAEQSANAASTDDAASTDRRAGIREEESTSERPPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J0</accession>
    <name>R4W2J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447805.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02911">
        <property type="protein sequence ID" value="AGN02911"/>
        <property type="gene ID" value="L593_14885"/>
    </dbReference>
    <dbReference type="GeneID" id="16181563"/>
    <dbReference type="KEGG" id="sali:L593_14885"/>
    <dbReference type="eggNOG" id="arCOG08159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327364_0_0_2"/>
    <dbReference type="OrthoDB" id="128739at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="98" mass="9936" checksum="C331C124D9DAA04B" modified="2013-07-24" version="1">MSDDEKESDSVGPDIDLEKIAADGDGSHGDAAAGDADTGHHGSDEEHSHGPDTHDHDDATTGRSTAPQSEFTTRQAMIGALVTAVGIVVAYAVPGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2L1</accession>
    <name>R4W2L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative divalent heavy-metal cations transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_00310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444911.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00310"/>
    <dbReference type="EnsemblBacteria" id="AGN00017">
        <property type="protein sequence ID" value="AGN00017"/>
        <property type="gene ID" value="L593_00310"/>
    </dbReference>
    <dbReference type="GeneID" id="16180673"/>
    <dbReference type="KEGG" id="sali:L593_00310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.62"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_0_2"/>
    <dbReference type="OrthoDB" id="62488at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="265" mass="28015" checksum="3D3F9580B4262743" modified="2013-07-24" version="1">MAVVENLVVVFVAGLITALATGLGALPFFFFDDISTRMNVALWGVASGIMLSASMFGLVGEGLAEGTILEVGIGALAGVLLVVVAHDLLMNSELDARDYEEADFAKLVLILGVLTVHSFPEGVAIGVSFADLNLGTGIWVLGLTIPPLAVFMTVAISIHNVPEGTAIAIPLRSMEVSEWRMVWWAVFSSLPQPIGAVLAFWFVRIAREFLPVGFGFAAGAMIYLVLSEFIPEALDLGSDMRRGGVPELVGGLLAGILAMIPLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Q1</accession>
    <name>R4W2Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444971.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00610"/>
    <dbReference type="EnsemblBacteria" id="AGN00077">
        <property type="protein sequence ID" value="AGN00077"/>
        <property type="gene ID" value="L593_00610"/>
    </dbReference>
    <dbReference type="GeneID" id="16181511"/>
    <dbReference type="KEGG" id="sali:L593_00610"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_2"/>
    <dbReference type="OrthoDB" id="66018at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41384" checksum="680C3263CDCA7A99" modified="2013-07-24" version="1">MTIDIGIVGAGNRGETHAGEYADVDGAEVVAVADIDEQAAEALAGAVGGTAYGDYRDMLDDADLDAIDVCVHNNLHRPVTVDAADAGCHVFCEKPMAATYTDAKAMMEATEEAGVHLGVQNHELFSDETRAAKTLRDEGKLGDPYFARGVFSRRRGRPYVDGYGTPSFVRKESAGGGPVIDIGTYVVGRLLHLLGNEPVERVSGATFEHTEDTYDTDLVGDNRDQYIERLAESGYDVEDSGMGFARLADGSLLSLRAAWHMFLPDDSDVLAGTKGGVQFDPFEFYTTSGDYQATISLDLEEYERRQALFEGDTGYDFERSIGQYHHWIDTITGAAEEVVPTGEIALNSMLVMEGIYLSQEAGRELTREEIAERSESTAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3A7</accession>
    <name>R4W3A7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diadenylate cyclase</fullName>
            <shortName evidence="6">DAC</shortName>
            <ecNumber evidence="6">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="6">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dacZ</name>
        <name evidence="8" type="ORF">L593_02305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate cyclase family. DacZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445306.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02305"/>
    <dbReference type="EnsemblBacteria" id="AGN00412">
        <property type="protein sequence ID" value="AGN00412"/>
        <property type="gene ID" value="L593_02305"/>
    </dbReference>
    <dbReference type="GeneID" id="16182326"/>
    <dbReference type="KEGG" id="sali:L593_02305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.467"/>
    <dbReference type="eggNOG" id="arCOG04453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063222_0_0_2"/>
    <dbReference type="OrthoDB" id="80301at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00840">
        <property type="entry name" value="DacZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014499">
        <property type="entry name" value="DAC_DacZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045586">
        <property type="entry name" value="DacZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19294">
        <property type="entry name" value="DUF5912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019073">
        <property type="entry name" value="UCP019073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="109"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="269" mass="29221" checksum="75A26BE5567C9354" modified="2013-07-24" version="1">MVEPNELLEEVVREVDGVLLFAPTASYYERFVDAEIDVVVVASENDIDADEFVELPVAFKDVYDRVRFGIEGALEQDLLADGDVVACVSSVFDEELDTVSRVRVDADSTSGVYDLFANTRAEPDVLRSVLELVIELGKKGQKGQPVGALFVVGDAGKVMNKSRPLSYNPFEKSHVHVGDPIVKVMLKEFSRLDGAFVISDAGKIVSAYRYLEPSAEGVDIPKGLGTRHMAAGAITRDTNATAIVLSESDGMVRAFKGGSLVLELDPEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W401</accession>
    <name>R4W401_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-type ATPase, translocating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445721.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04380"/>
    <dbReference type="EnsemblBacteria" id="AGN00827">
        <property type="protein sequence ID" value="AGN00827"/>
        <property type="gene ID" value="L593_04380"/>
    </dbReference>
    <dbReference type="GeneID" id="16180921"/>
    <dbReference type="KEGG" id="sali:L593_04380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.891"/>
    <dbReference type="eggNOG" id="arCOG01578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862267_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="35114" checksum="56BD54D2D9B4837C" modified="2013-07-24" version="1">MDEHPIRTPWAKSSAETLAHYDVSAEEGLSEDDVETRRERVGPNALREAERRDWWNVLADQFKSFIVLLLAVAGVAAFALDETIEGVSILVVLLINGLIGFVTELRAIKSMESLQEMTEIEARVRRDGEVEKVPAEDLVPGDVVLLDAGNVVPADLRVIDPSKLQADESALTGESVPVGKTSEVLEEDAPLAERENMLYKGTSVTRGTAEAVVTMSFLTLAFAQLWHVFNMRELASGIVRNEVTRNPYVWGALVLSASLVIGTLYLPGVSLALSTTPIGPESWLVVLGMSLLPLGAGQVVLEFRRRVGTPNLGTRLGRLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W437</accession>
    <name>R4W437_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445786.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04715"/>
    <dbReference type="EnsemblBacteria" id="AGN00892">
        <property type="protein sequence ID" value="AGN00892"/>
        <property type="gene ID" value="L593_04715"/>
    </dbReference>
    <dbReference type="GeneID" id="16180991"/>
    <dbReference type="KEGG" id="sali:L593_04715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.964"/>
    <dbReference type="eggNOG" id="arCOG04490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134253_0_0_2"/>
    <dbReference type="OrthoDB" id="100439at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="16218" checksum="7E4A7AFEFDDC2B1E" modified="2013-07-24" version="1">MQPIRIVWGTGRGPTALAAYDAALAEASVHDYNLVRLSSVIPDGPAIEEVGEAPDLGPAGEGLHVVEASARGDSGPQSAVLAWARSPEGPGVFYEAGASEPADVVQAEAKAGIESGLDLRDREYGEPQFRTVSIDADSAEGYAAAVAIAAYGESEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4E9</accession>
    <name>R4W4E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_05690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05690"/>
    <dbReference type="EnsemblBacteria" id="AGN01087">
        <property type="protein sequence ID" value="AGN01087"/>
        <property type="gene ID" value="L593_05690"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1165"/>
    <dbReference type="eggNOG" id="arCOG00167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="166"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="42414" checksum="A7A85E8F3B56CEB7" modified="2013-07-24" version="1">MDNTPDDPDDTDMSGTIQRRMQAVRDWIDAKIAAIVTWFRKLPDRIRDFLDRTPADAQAILLLGVVSFAAAAYFFWRSPGQAATPLTLFAGATAVGWIRHRGRTAKALTMLASVVTVAILLLIISFLVLHSRDAFEHMGTELLWRLEPPFWEAPSPDGTYSLTPLMVGTALTTVIATMIAAPLGIAGAVFISEMAPRRVREVVKPGIELLAGIPSITYGFVGLTIVNQYFYTEFQTPTIASYFAAGVMIGLMALPTVVSVAEDALASVPESMKSGSLAMGSTEWQTTKSVTIPAAFSGVSAAVLLGVGRAMGETMAATVMLSHTKGVPDPFFDVFSRYGETLTTVIASEAPNAIGGMHESALFAAGVVLFVSVMLLSITAQYVEWRMHRKLGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4W9</accession>
    <name>R4W4W9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446271.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07150"/>
    <dbReference type="EnsemblBacteria" id="AGN01377">
        <property type="protein sequence ID" value="AGN01377"/>
        <property type="gene ID" value="L593_07150"/>
    </dbReference>
    <dbReference type="GeneID" id="16182018"/>
    <dbReference type="KEGG" id="sali:L593_07150"/>
    <dbReference type="eggNOG" id="arCOG04616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2839256_0_0_2"/>
    <dbReference type="OrthoDB" id="122409at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043823">
        <property type="entry name" value="DUF5800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19115">
        <property type="entry name" value="DUF5800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="67" mass="7659" checksum="DDF3FA48A88545EC" modified="2013-07-24" version="1">MTSLAFDEQGVDVVYQGTEFRLEKELIEEATQKNYWEVTDHEVLKLVEKGPDLGGEPRRVGDILQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W503</accession>
    <name>R4W503_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glyA</name>
        <name evidence="12" type="ORF">L593_07460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07460"/>
    <dbReference type="EnsemblBacteria" id="AGN01437">
        <property type="protein sequence ID" value="AGN01437"/>
        <property type="gene ID" value="L593_07460"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1524"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="11">
        <location>
            <begin position="50"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="487" mass="51561" checksum="1B0662F4866E4562" modified="2013-07-24" version="1">MRFYRHSVDRVVSDVIGLMTGDPDGSSMRDPSPESDRASECAADRTASALADADPDVASIVGEERRRQESTLSLIASENCASRAVMAAQGSCLTNKYAEGEPGDRYYAGCEHVDDLERLATRRAEELFDVAHANVQPHAGTQANVAAYEALLEPGDRICSLGIGDGGHLSHGHPATLVGSHYDVATYDVDPETGYLDYDAVEATVRDTDPDLVVAGYSAYPRTVDWERFREIADAVDAWLLADIAHLTGLIAADEYPSPVGVADVVTGSTHKTIRAGRGGIVMTDDDSLADDLDAAVFPGVQGGPLVHNMAGKAVGFGEALRGEFEGYAERVLDTADALAERLQKRGYALVSEGTDCHFALVDLRPTDPDLPGTAAEDALERAGLVVSRSAVPGDERPTHVGSGIRLGTPALVSRGLGVPEVRQVADWIADVLDAPENEAVIAGTRAKVRECCLEHPIYDDGWTPATSAASVEGPSDGLDDAPEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W517</accession>
    <name>R4W517_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446356.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07585"/>
    <dbReference type="EnsemblBacteria" id="AGN01462">
        <property type="protein sequence ID" value="AGN01462"/>
        <property type="gene ID" value="L593_07585"/>
    </dbReference>
    <dbReference type="GeneID" id="16182158"/>
    <dbReference type="KEGG" id="sali:L593_07585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1554"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313456_0_0_2"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="826" mass="90311" checksum="7B1AD641F37DF68D" modified="2013-07-24" version="1">MTEPSDWRAIFGHEEPYEPQVDGVETALATAREGGYLALEGACGTGKTMLALTAGLHLVRDPESDFSRVLVLTSVKQQLRQFEDDLRLINEELPEEFRPYSGLTLVGKADVCPYSREHAGGIDEENVYDRCEGLRDRTRGLTGEDGETSASQLVSAARRQQIGLDDGATRGAAAATYLETAGEPAPYPRELPEHDDEVEYCPFYAQFLDELPDGADSDPAEAIPFEFRERGLMDTEDLVGLSVEHGTCPHSMMGALLGEVEVVLGNYYHAFDPTTSTAFTAPILDSETFVICDEAHMLEPRVRDLVSDGVADATLRDAEAELTRVIEPLREGRTEGGADEQLVKNELASVDLTRSDLESVRSFVRDLRESLDRRVVDHLNREHPGWRDSLEGLPDEEIPLRPPESPQTDEITEWASRNGHEEAWYRAEAVGAFVGRLLDEHEDEERERAAPAAGRTLAAWARCDHEHYFRSLALERTWDATHPPESWRRAYNGRLNLHNCVPGDAIGDRLADFGGGVLMSATLAPLDVFAEVSGLAHLQAEYDRPVETRQYGLDFPVENRESYAVAAPKFTYDNRGPPPARGGLGGPPDGAAGDAAADGSRAATGSGATSSDGFDGVGDEGTRAVRRAYLDAISTVADAPGNVLVGMPSYAEAEWAAAAIDGDTRVDKPVLLDESSAESETQALKDEFFAGPSKVLVTSLRGTLTEGVDYRGDRLAAAVVCGVPIVDTSSPRTRAIRAAYDRAFGGGERSVGFEYSLTIPAVRKARQAIGRVIRGPEEVGVRVLVDERYAREDWDSVRQYLPVEFDAVSPDMLDLGLDRFWDRHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5C6</accession>
    <name>R4W5C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446541.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08510"/>
    <dbReference type="EnsemblBacteria" id="AGN01647">
        <property type="protein sequence ID" value="AGN01647"/>
        <property type="gene ID" value="L593_08510"/>
    </dbReference>
    <dbReference type="GeneID" id="16182469"/>
    <dbReference type="KEGG" id="sali:L593_08510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1742"/>
    <dbReference type="eggNOG" id="arCOG01706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_2_3_2"/>
    <dbReference type="OrthoDB" id="64253at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="175"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="28986" checksum="3C2B4A5E0D70203E" modified="2013-07-24" version="1">MNGGDDRIEPLSPRRRGTVDYMRMAGRRSNVHGLVEVDVTDARAAIDDAEAETGEPLSFTAFVVSCLARAIEDHPDVNAYRDWRGRVHVFEDVDVNVLVETTIDGEQVGVPHVLRRANERSVRSIHDEIRSAQASSDPTNLSWAGRIALRLPGPIRRLVWRLPQVFPRRWKRLAGTVAVTSVGMFGAGGGWAISPTNYTVQLTVGGIDEKPRFVDGELRNREILDLTVTVDHDVVDGAAAARFGGRLRELLEDAHGLDPPEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5D6</accession>
    <name>R4W5D6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="10" type="ORF">L593_08635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446566.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08635"/>
    <dbReference type="EnsemblBacteria" id="AGN01672">
        <property type="protein sequence ID" value="AGN01672"/>
        <property type="gene ID" value="L593_08635"/>
    </dbReference>
    <dbReference type="GeneID" id="16182491"/>
    <dbReference type="KEGG" id="sali:L593_08635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1770"/>
    <dbReference type="eggNOG" id="arCOG02676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_0_2"/>
    <dbReference type="OrthoDB" id="101275at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="9">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="14581" checksum="7F2C6A443F02F70D" modified="2013-07-24" version="1">MHDDALRTDGGEPPELDFGESGRIPAIAQDAASGEVLMLAYVTREAVETTRETGRAHYYSRSREELWEKGATSGHTQEVREIRVDCDGDAILYLVDQEGGACHTGYESCFYRTVDGEIVGERVFDPDDVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5P6</accession>
    <name>R4W5P6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446761.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09610"/>
    <dbReference type="EnsemblBacteria" id="AGN01867">
        <property type="protein sequence ID" value="AGN01867"/>
        <property type="gene ID" value="L593_09610"/>
    </dbReference>
    <dbReference type="GeneID" id="16182614"/>
    <dbReference type="KEGG" id="sali:L593_09610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1979"/>
    <dbReference type="eggNOG" id="arCOG06224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016294_2_0_2"/>
    <dbReference type="OrthoDB" id="44541at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="507" mass="55339" checksum="8C499CB3AE94BB5E" modified="2013-07-24" version="1">MAQGSNAEWIVPTTDARSLPVVELLTGRGFVSGKSGSGKSNTVGVIAEELLENGYNFLIVDTEGEYYGLQEQYQLLHVGGDEFADVQVGPNHAEKLAEIGLERNVPIILDVSGFDDVDESRELITRTIEELFRREKKIRKPFLLVVEEMQEYLPQQGSAGELGEILERVAKRGRKRGLGMCGVSQRPSSVDKDFITQCDWMAWHRLTWEADVKVVSKIIGSDRKQALTDLDPGEAFLLTDWDDTIERVQFRRKHTHDAGATPGLESYDRPDLKTVGTELINEIESSEQTKAEAEANARQDDLQPETGSLEDLTIPEDTSDPAPADAAEDGSASASDSAEPPGPPMETQPIEVDEDDPDEAVQRLQQRNRILEREVEELRTLLQSIEPDHERAADHADQPEFATAADGDGGLDADSSPGGTDTKRAPPAPAPAGGSPSPSGSASASPSSKASSPTPTAPSRPMPPERPSNRSGLAGVILEFGEMIIYLLKSTSYRFRLAWFKLRQKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S7</accession>
    <name>R4W5S7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="10">IGPS</shortName>
            <ecNumber evidence="4 10">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="12" type="ORF">L593_00090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444867.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00090"/>
    <dbReference type="EnsemblBacteria" id="AGM99972">
        <property type="protein sequence ID" value="AGM99972"/>
        <property type="gene ID" value="L593_00090"/>
    </dbReference>
    <dbReference type="GeneID" id="16180908"/>
    <dbReference type="KEGG" id="sali:L593_00090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.18"/>
    <dbReference type="eggNOG" id="arCOG01088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_1_2"/>
    <dbReference type="OrthoDB" id="98284at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="11">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGM99972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="275" mass="28916" checksum="3FBD21CCF110387C" modified="2013-07-24" version="1">MDTEEPIAPAVRSILDAARDRGAPDRRLTVDPRSLVGAFEEAESDGRMPVIAEVKPTSPTAEGTRTDDPVALAEAMVAGGASALSVLTEPEHFGGSPETLERVREVVDVPVLRKDFLLEEGQLDVVEADVVLLIVRFVDDLSGMLDAARERGFQVLVEVHTPAEFEAAVDAGADVIGINNRDLAALEVDLGTTEDVLDAVDVPDDVTVIAESGIQTAADARRLREAGADALLIGSAIMDHAAAESDGASVTTDSGVDTVRSNTETFTTAETEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U9</accession>
    <name>R4W5U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisS</name>
        <name evidence="11" type="ORF">L593_10035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446846.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10035"/>
    <dbReference type="EnsemblBacteria" id="AGN01952">
        <property type="protein sequence ID" value="AGN01952"/>
        <property type="gene ID" value="L593_10035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180287"/>
    <dbReference type="KEGG" id="sali:L593_10035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2069"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_1_2"/>
    <dbReference type="OrthoDB" id="47919at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="438" mass="48510" checksum="B24A3DDE1388AC1E" modified="2013-07-24" version="1">MYDRIKGFRDTYPEAMQARRWLFDSIESTARGYGFREIDTPALERTEMYVDKSGEEIVEELYSFEDQGDRSVALTPELTPTVARMVAERGQELTKPIKWFSTRKFWRYEQVQQGRFREFYQTNVDIFGSAEPDADAEVLAVAAEMLTGLGLAPEDFEFRVSHRDVLGGLLEAFDAEDGTEIDTEDAIRAVDKRAKLDRVEYIDELVAAGLSESQAGTFDDLLDTPEEDLDDLVAFAENERIADAVENLQAVLDAAADFGVREYCTLSLSTARGLDYYTGTVFECFDATGEVSRAVFGGGRYDDLIGDLGGPDTPAVGFAPGDATLSLLCKRAGVWPEESLTTDYYVLTAGDTRSQAAELARELRDRGHVVESDVADRGFGAQLDYADSIEAETVVIVGEQDLANDEYTIKDMASGDQTTVPVDAFPGDLERPTYEDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V2</accession>
    <name>R4W5V2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="9" type="ORF">L593_10060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5 7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446851.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10060"/>
    <dbReference type="EnsemblBacteria" id="AGN01957">
        <property type="protein sequence ID" value="AGN01957"/>
        <property type="gene ID" value="L593_10060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180579"/>
    <dbReference type="KEGG" id="sali:L593_10060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2074"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OrthoDB" id="80498at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="8">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="190" mass="21038" checksum="1CD7782F9E9FC4DF" modified="2013-07-24" version="1">MSETASQPLLFGEWEIEGIEFSDPSTERYISITPVAHSMGRHADKQFAKSEISIVERLINRLMQTEENTGKKQQATKIVREAFREINERADENPIQVLVEAVENSAPREETVRLKYGGISVPKAVDIAPQRRVDTALEFLAQGTHNAAFKSPTDVEEALADQLLGAANADVSTYAVNQKEETERVAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W5</accession>
    <name>R4W5W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase active site domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01977">
        <property type="protein sequence ID" value="AGN01977"/>
        <property type="gene ID" value="L593_10160"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2094"/>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="407"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="621" mass="68987" checksum="D0BB98F6E904CBF8" modified="2013-07-24" version="1">MPRDDVDETLEALASLPTLAQATVSPDGDRIAFYHDGTGRNELHVLDVATGEVEQWSDGDVPRDSKSTLEWDADGDRMFFHHDQAGNEQFDVYAIDAAGTVESVYESAGQSGLHDVGADGDVVLVGSNHEGQMNLYSHDLDADETTTVTEYERATLVGLLSPDGEQVAFATNESDEFSNVDSYVADADGGNPRNLQIGDTGAECVPADWHPDGDRLLVADNTTDVGRCGIYDLDADEVTWYGEGADEEMAECFLPGGDRFLALRMRDATVTPVIYDVETGESRAFEVPSGVSEFGHGESPVLADGRVVLTHESPTTRPRIIAYDLETDEYDVLREAEYGSFDREDFVDAEYVTFESDGVPETPARAVEHEPYDELEIGALLYDSGERPSPLIVHPHGGPRLHETKNFDVFTQFLASRGYSVLQVNYRGSTGRGREFVERLYDDWGGAEQGDVATAAEHVLETRDWIDEDRVIAYGRSFGGFSAYWQSVQYPDLYDAVISWVGVSDLRDMYENTMPHFRSELMEKYMGDPDENADLYEERSPITHVENVQGPLLMLHGANDTRVPVSQARRFDEALQEAGFEEGPDGDYEYVELDAEGHSSSDVRRKIRVFSLVDDFLDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y0</accession>
    <name>R4W5Y0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446896.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10285"/>
    <dbReference type="EnsemblBacteria" id="AGN02002">
        <property type="protein sequence ID" value="AGN02002"/>
        <property type="gene ID" value="L593_10285"/>
    </dbReference>
    <dbReference type="GeneID" id="16181710"/>
    <dbReference type="KEGG" id="sali:L593_10285"/>
    <dbReference type="eggNOG" id="arCOG08175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157001_1_1_2"/>
    <dbReference type="OrthoDB" id="117611at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10478" checksum="31EA4040305F30E8" modified="2013-07-24" version="1">MVDALHVATAVSALNIAILIALTAVWIRNYREFRTPLVLALVVFGLVLLAENGVAIYFFFSMKMLYAADATVQSAVAVLRGMQFVALAFLAWATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W684</accession>
    <name>R4W684_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01225"/>
    <dbReference type="EnsemblBacteria" id="AGN00198">
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        <property type="gene ID" value="L593_01225"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01225"/>
    <dbReference type="eggNOG" id="arCOG06349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2985595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="6230" checksum="56BEF38608415F6A" modified="2013-07-24" version="1">MQCHYCEKPAAYAAESEGVKVGLCEEHFQTRIEELAESDTLESIRERVDVDRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B9</accession>
    <name>R4W6B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11310"/>
    <dbReference type="EnsemblBacteria" id="AGN02207">
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    </dbReference>
    <dbReference type="GeneID" id="16180214"/>
    <dbReference type="KEGG" id="sali:L593_11310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2333"/>
    <dbReference type="eggNOG" id="arCOG01395">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064233_0_0_2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="37608" checksum="747B43EC12CE4BAA" modified="2013-07-24" version="1">MRVHFDVTHPAHVHLFRHAIESLAAEGHAVGVTAREKEVTTALLDAYGIEHEVLSRKREAAWALGPEWGVRTLRTLDYVRRFDPDVVVSQLNPSAVGAATLTRTPSVVFHDSETAGRLADVLAPLTDVVCSPTGVQQRLGDNHRFYDGFHELAYLHPDRFEADPDLLAEYGVDSEASYAVVRFVSMGAYHDVGEAGLAREQKRRLVETLAEHGPVYVSSEGEPPADLPGDSVPVPPDAIHHLLANASVFVGDSDTMAIEAAVLGTPTVRVDSFGDGDVLGCFNELERFDLVHSTTDGDEAVERAAELADDPAATDRWRRRRDRLLDETVDVSAYMVDTIREVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D7</accession>
    <name>R4W6D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447136.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02242">
        <property type="protein sequence ID" value="AGN02242"/>
        <property type="gene ID" value="L593_11495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180984"/>
    <dbReference type="KEGG" id="sali:L593_11495"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093378_2_0_2"/>
    <dbReference type="OrthoDB" id="97382at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="19540" checksum="A74292F2C63C794D" modified="2013-07-24" version="1">MFRTSTIPEAEIYEVLANDRRRATLRALARSSEDRGIPLSDLATAVAERETGASPPPAAARESVYNSLHQTHLPMLDELEIVRYDHDARTVYRRDRVRDVERYMEVVSALGISWSELYRTLGVCSLGLVTTALAGVDPVAGVDPLLWAIASLVTFAVAIAAQLWSNRRYVRRGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F3</accession>
    <name>R4W6F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_01985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445242.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01985"/>
    <dbReference type="EnsemblBacteria" id="AGN00348">
        <property type="protein sequence ID" value="AGN00348"/>
        <property type="gene ID" value="L593_01985"/>
    </dbReference>
    <dbReference type="GeneID" id="16180016"/>
    <dbReference type="KEGG" id="sali:L593_01985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.403"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="31"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="31462" checksum="2A3E60F9D5EF6427" modified="2013-07-24" version="1">MSDTDDAASADEQIATGAGVDRTANTFLGDVWVNFKRWNLKAVRNPFVLVVSLVQPIIFLVLFTEVFGNVAGSAVNRGIPGISYETFLVPAIAIQVALAAAVTSGIGLVNDIENGMFEKVLVSPMNRTAVFLGKTAAEVFRITVQIGIILVLGVLLGAEIATGVVGALGIIGVGILFSLWFVAVSNSLALLTRDQESTIIGANLLQFPLLFLSTAFLPLDVMPEWIQTFAKLNPVTYGVDAARSLMLDRDTMTVIQVSWFDGTLDGVVPGVLVLVGLDLALGAIAVVLLSRASSSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G0</accession>
    <name>R4W6G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="80" mass="8504" checksum="469FAA650B9F8974" modified="2013-07-24" version="1">MPLKPEILSDEQFLHELAGITGLGWTASTLGFIGSLIWYGDAPGGSHPLESRVLLYLGICCFVATIGLDALRTVLDDAGE</sequence>
</entry>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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    </evidence>
    <sequence length="95" mass="10535" checksum="D666DF1292B82300" modified="2013-07-24" version="1">MADTYTLTIESDSEHEDETVEVPQGAIDALAQDDDSPTVMAGDLVMLGLAQQLHANVFHSEQAPSEQIQQANEDLDELFEDRFGMTFEEMAGHEH</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <sequence length="150" mass="16346" checksum="B0EC6132BA538D9F" modified="2013-07-24" version="1">MFGHDELAGMVDAFGALDRAELERACSETAFRRGEEFDEAAVQAAIDDAVDAYALVEHDGRLVPGPAAFPTLPDGAEDLPHILDLERRDVDRDAVAAAVAERFEREVDAAIDAGDDEACADLLDRSYEVESWGPVDLDDARERLDAAREE</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
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        <location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="335" mass="35341" checksum="EC14AE2904FF1BC8" modified="2013-07-24" version="1">MFLVALSLLFLAAVPSGAGAAQPPCADAGNDTIVVATPPADDPIGPDGTVAVYHGSELVVHLCQSENSTRTLDDGALQWGTVLESTDERLRIRVEGPTNDSLGTLVTPGTASGPSLAIVDRTVETSLVTGSIPVASADQRASLRRAESTYVQRERLLERQLQRLENATGTVEDGGEPTGDPIGETMATREAYRNASEQFRAELYAVADSSVGGPGSAAALRALGARSTGLENRTRHRLQAHDAVLRDRQRSLTWSLRLRIFGVGAIGILIGGVAGALLPIRRGRAARRRLAQGEWTTYSRRAILLPAAVGLVLLCLGIGWLAVTFGDVIVEVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X5</accession>
    <name>R4W6X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445517.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03360"/>
    <dbReference type="EnsemblBacteria" id="AGN00623">
        <property type="protein sequence ID" value="AGN00623"/>
        <property type="gene ID" value="L593_03360"/>
    </dbReference>
    <dbReference type="GeneID" id="16180513"/>
    <dbReference type="KEGG" id="sali:L593_03360"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094015_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="19453" checksum="CB0BA87EEFD3D913" modified="2013-07-24" version="1">MTVIVGPTLPDPYSDRVETVWDDLVAAFGIDRYVNPYPHVTLYALDDVSDLQTVEDVVRDVAANHEPVPVHTDGIGVFPQNAVWLPVARSPELAALHRDVVAAVGDLGDAPVPFYDPARWFPHVGFALGLEDELTGEIVTYLLNYDFAWSFEFETIAITRPPEEGDEHELVAAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W744</accession>
    <name>R4W744_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, chain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445612.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03835"/>
    <dbReference type="EnsemblBacteria" id="AGN00718">
        <property type="protein sequence ID" value="AGN00718"/>
        <property type="gene ID" value="L593_03835"/>
    </dbReference>
    <dbReference type="GeneID" id="16180693"/>
    <dbReference type="KEGG" id="sali:L593_03835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.778"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_3_2"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="17638" checksum="8302EEFB80E37868" modified="2013-07-24" version="1">MIGVLKAMATTMKRAVGDNTFTVQYPEETPDVSARFRGVHKFSQERCIWCRQCENVCPNDTIQIVTDEQRNGEQYNLHIGQCIYCRLCEEVCPVDAILLTQNFEFTGDTKDDLVYNKEQLMSVPWYKDIDPLESREPDRGAWIGEGEGEVDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F6</accession>
    <name>R4W7F6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">DGGGP synthase</shortName>
            <shortName evidence="9">DGGGPS</shortName>
            <ecNumber evidence="9">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ubiA</name>
        <name evidence="10" type="ORF">L593_14740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447776.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14740"/>
    <dbReference type="EnsemblBacteria" id="AGN02882">
        <property type="protein sequence ID" value="AGN02882"/>
        <property type="gene ID" value="L593_14740"/>
    </dbReference>
    <dbReference type="GeneID" id="16181439"/>
    <dbReference type="KEGG" id="sali:L593_14740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3010"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_1_1_2"/>
    <dbReference type="OrthoDB" id="104789at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="281" mass="28859" checksum="64D2768EDABE7AC3" modified="2013-07-24" version="1">MDVGTALRGYFDLTRAGNAITSGVLTFVGAYVTGGAFEEPLAATAAVVATIFGVAAGNSINDYFDRDIDAINAPDRPLPRGAVSPRGALLFSGGLFAGAVVLALTLPPLAIAIALVNLVALVAYTKLFKGLPGAGNVVVAYLGGSTFLFGAAAVATPDAAALVLFVLAALSTLAREVVKDVEDVEGDRSEGLNTLPIAIGERRSLQFAVLLVLVAVLVSPAPYLVDALGVSYLIVVVPALAILVYASYRSFEDPTRGQSFLKYGMLVATLAFVVGRAVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7M5</accession>
    <name>R4W7M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-histone chromosomal MC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA against thermal denaturation and modulates transcription.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01053">
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        <property type="gene ID" value="L593_05520"/>
    </dbReference>
    <dbReference type="GeneID" id="16181882"/>
    <dbReference type="KEGG" id="sali:L593_05520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1128"/>
    <dbReference type="eggNOG" id="arCOG04743">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MC1"/>
    </dbReference>
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        <property type="entry name" value="MC1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05854">
        <property type="entry name" value="MC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF102875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MC1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="101" mass="11300" checksum="8B9306447AADFA93" modified="2013-07-24" version="1">MVREDGKRNFALREDGDESSVFSGNTPRQAALKAARRLEPASSESAANETELRLREKGTDKVHIYDGWAWEENAPDDSPDWMPGDITEANVSKKGIEHLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q6</accession>
    <name>R4W7Q6_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGM99968">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="530" mass="57176" checksum="0C48662F9084A847" modified="2013-07-24" version="1">MNTSSAPTIVAISPNPYQDGDAGESVTIDFSRPTNTSGWTIVDDEGTVARLPNETITGRVVFAVEPDAVRSVEPDAVASANPDAVDREDARTVRSLGGALELANGGEELRLRRPGGAVVATVQYDDAPEGERYRRVGDGWQWRPVGGTSIEPIETSPDAARAFVLPDAPGVVEDELRSADERIYLAGYTLTSERVVGALLDANRSGIDVRVLLEGSPVGGVSRRQVDALDRLREAGVSITVRTGERDPFSFHHAKYAVIDDRALVLTENFKPAGTGGHSSRGWGVVLDDTAMARGLADLFRTDSTGPGTTSWSARRSSVDPVADYASRTTFPTRFEPATVQVERVRLLVAPDNARPDLAELLRSANDSIRIEQMAIEGVDDPLLQASIDAARNGTEVEILLSSASYVRGENRRLVRAIDRLAAREDLPISADLVDPRGRFDKVHAKVAIVDGEHVVLGSLNWNPTAYGENREVVVVLTGEEVAEYYGAVYAADARDRTLWRIPVGVVGVLAGIWIALGILAVVRIRWSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R4</accession>
    <name>R4W7R4_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05945"/>
    <dbReference type="EnsemblBacteria" id="AGN01138">
        <property type="protein sequence ID" value="AGN01138"/>
        <property type="gene ID" value="L593_05945"/>
    </dbReference>
    <dbReference type="GeneID" id="16181558"/>
    <dbReference type="KEGG" id="sali:L593_05945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1218"/>
    <dbReference type="eggNOG" id="arCOG04572">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932567_0_0_2"/>
    <dbReference type="OrthoDB" id="35238at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="36305" checksum="FBB8A96904B47B03" modified="2013-07-24" version="1">MTEPVDVAVPRKGRPLEAVLGRLADRAGDASAAPTGHHRDVASTGEDGTPSAGGTPSDAPTVAEVADDVISTLRYEKAVTKDAAEDDPDATVYDRLAEYSDLEAPYRPEYTLLRDDRAGRPRRIVFDALTLWIDGTPIRLVGREEPFRAVRTHEVPLAFDSADLVLEEVVELRPEPLTSIDDVNARIDPQDTDVRVATGLGDTVHHTLLGTPELRTAGDGPPDELDRSFVADYEGPLCVSPRYERLVAAVLGTDAIEGVEFVHPENGRDEEAAIADAGLGVYLTVTGSTAREHGLELGSKLFPSETVLMENVVETGSPEDRVRSLIAGEDIETALSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U5</accession>
    <name>R4W7U5_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06245"/>
    <dbReference type="EnsemblBacteria" id="AGN01198">
        <property type="protein sequence ID" value="AGN01198"/>
        <property type="gene ID" value="L593_06245"/>
    </dbReference>
    <dbReference type="GeneID" id="16181670"/>
    <dbReference type="KEGG" id="sali:L593_06245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1276"/>
    <dbReference type="eggNOG" id="arCOG05223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011736_1_2_2"/>
    <dbReference type="OrthoDB" id="106124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="453"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="705" mass="81983" checksum="E3C773F8EFC0FE46" modified="2013-07-24" version="1">MESGKKSLEELTTAGVFHVPQYQRYYSWTEPEWDDLWTDLSTLPEGKQHYFGTVIIQETQRTVTAHRDGYGSDTEKDVNLLIDGQQRLTSLTLLVKSMTEALREIAPETEHEDQILEEVADMRQQFIEEDNVYFLKLLDEDDSEFLERIVDGRYQRDPERPSQRKLVDAKSFFDEKIAELRNRPDLEPLDVANQLNRIWETILDLELMVYVVEAGNPEKATLIFDSVNDRGRALSTFDKTKSFLMRMAYLAADDESEGQATIDSIRQAFGEMYDDHQKILDSPYVDDISDDAIQRYHFITFFDWTERQDHQTPTFLDLLKARIRSLREEDPEACLAYIREYTEGLEAGFDNLADVLSQTGDGDIANLVHRIHKLRHATKFYPILLKAWPDLDQAEQEDLLDVIETYIFRVYAIGNHPTYTGRSSLQTLARDTEQGSDAEAWINGIVDVMNNYQDDDQFTRTLSRSDLYTSVSSQDLRYLFYFYNEYRAREEKEEGSITLDEAMGEEYTVEHIWPQTVDEIPFEDTGSYPNLEQRYNAYKHRLGNLTLASKSWNSEWGNDDFETKRTEGYEESTLWVQKDIRDYEDWSIDNIQDREEILIQFVMEFWDAPSTRFGDIDEPENAISELSSRENTVLHALCDASSGGARRYIHRKACERADSSFENPDSNDERNEVGSILSRLARVGLADREKRTWYATDEARAAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z3</accession>
    <name>R4W7Z3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="2">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="509" mass="55855" checksum="51750D4FE1126B83" modified="2013-07-24" version="1">MSPPQDTFGHYVGGEWIDGSGAETFTSEDPATGDTLAEFHRGTPEDVEAAVGAAEDAFEEWRSLSYIDRAEYLWEIYHELRDRHEELGEIVTQECGKEISEGKADVTEAWHMVEWAAGNARHPHGDVVPSEIAAKDSYMRRQPRGVVGCITPWNFPVAIPFWHMAVSLVEGNTVVWKPAEQTPWCGQIIAEMFEDTGIPDGVFNMVQGFGDAGAAIVDDERVPTVLFTGSAEVGHSIADEIGGQPGRDVALEMGGKNAIVVTEEADLDIAVHSAVMSSFKTTGQRCVSSERLIVHTDVYDEFKRRFVDLAESVAVGDPLDEDTFMGPAIDERQVEKFHEYNDLARKEGANVLVDRADLDADEIPGGNTEGHWIGPFVYEIEYDPTLRCLKEEVFGPHVALVEYEGTIEDAVEIHNDVPYGLAGAVISEDYRQLNYYRDRGEVGLAYANLPCIGAEVHLPFGGVKKSGKGAPSAREVIESVTDRTAWTLNNDEDIAMAQGLSADITTEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W819</accession>
    <name>R4W819_9EURY</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN01428">
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    </dbReference>
    <dbReference type="GeneID" id="16182117"/>
    <dbReference type="KEGG" id="sali:L593_07415"/>
    <dbReference type="eggNOG" id="arCOG00826">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16876" checksum="B3443815E2C77224" modified="2013-07-24" version="1">MAELRELTTDAEWERAVPILRQLWSYVDEAFVRSWRDEDDYRLLGWFAKATGGDADARGASAESLVAVAGVYVQTVVHHERSLWIHDLVVDEAHRGEGHGEALLDALETWGETRDCDHVALVCAADNDEAAAFYEHVGMEPFGTVYEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I3</accession>
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        <lineage>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01808.1"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01808">
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        <property type="gene ID" value="L593_09315"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG13459">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="149" mass="15567" checksum="D720195DDAAFB600" modified="2013-07-24" version="1">MADSLAPSFDVERGPILVGAVVFVIGGVIGLFGFQRPGYLLAASLFAGVAAGLRGGYYSQSSTEGLVSVVAGLVLLFPALVVFRAFWLSAFPKAGDSVYEFAFLGVVGAIADVAVFGPFFLLFGYLGGSLVGRFQSGPERSIRRSENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I8</accession>
    <name>R4W8I8_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_09390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446717.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09390"/>
    <dbReference type="EnsemblBacteria" id="AGN01823">
        <property type="protein sequence ID" value="AGN01823"/>
        <property type="gene ID" value="L593_09390"/>
    </dbReference>
    <dbReference type="GeneID" id="16182691"/>
    <dbReference type="KEGG" id="sali:L593_09390"/>
    <dbReference type="eggNOG" id="arCOG02868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_2"/>
    <dbReference type="OrthoDB" id="105143at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="4">
        <location>
            <begin position="51"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="225" mass="24140" checksum="684CA96E9C463EFC" modified="2013-07-24" version="1">MRRRSVLAGIAGAASLGTATSLAGCLDTGSGGSGGQPLSEHPASRNLDGQPSLGDVPTAAEKVIVAFEDPTCSNCERFHTGSFQAVKREILEPESAAYVYRPYRYTGRGWATPAIHATLEVTAREPPVAWDLLDFYYENTYSISGGTFADETRSFLSENTDLDADTILAAAENRAHQSVLETAEADGDEAGVNSTPTFFLYKNERFKNKLVGVQDVTAFQAGFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K3</accession>
    <name>R4W8K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445588.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03715"/>
    <dbReference type="EnsemblBacteria" id="AGN00694">
        <property type="protein sequence ID" value="AGN00694"/>
        <property type="gene ID" value="L593_03715"/>
    </dbReference>
    <dbReference type="GeneID" id="16180685"/>
    <dbReference type="KEGG" id="sali:L593_03715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.754"/>
    <dbReference type="eggNOG" id="arCOG02921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394638_0_0_2"/>
    <dbReference type="OrthoDB" id="115753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017533">
        <property type="entry name" value="Halocyanin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03102">
        <property type="entry name" value="halo_cynanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="698" mass="73958" checksum="8F330459C2013ABC" modified="2013-07-24" version="1">MNHERRRFLQIGGAAAVAAIAGCTGDSNDGDDSGNGTNSVDGSAGGGTTDGDSGFGSGDGAEFDFGGWLADTDNYDGTTVDERGASSVTIQVGAEANGGAFGFAPPAVWVDPGTDVVWEWTGDGGSHNVVAESGAEFRSGDPTGDAGTTFSQRFDDTGIVTYYCNPHRDMGMKGAVVVGEPEEGAGENGASAYGFQAASMDAYWYSLYNMSTNIAMSGNGVPFPLNDQMEELQDQRMPAMLEAADVDRPPIANPNLSLAAFTEGDPHFTQEPVLEDDTGRPDASTLGWDKSQSSGVVSPSSVAWTHLKGVTWAKNFQAHFDVLPTEMAPKFRAQLLSTLAQVGINAAILVGGSRENGALTHGDSWEFLSQYRPSAGEIVDDSRRPHHHAAMVWFLSDMTSLAQNGWFGYENPRPLLPKAEGADAVFDPPVGIQEITDGVAATTMDLFTPAEIVEQESTRSVGLMLAAIGYYGPQAGGEAQRNAAAQYANDLASVIEDTLTDDGRVENGAANQAATQGIVAQGLLWASQLDGVDHADTADRVVDFLIEELWDENAGTFASGTDDATYTITARDAGDLTGGLNAADVLLERSDVQETFARFFDQTFNRGELQRAERPPSRDESAEHTLPLPPAAGGEFGQAAVYNGAVEYDPAADEWTVTDDRFYTEEALYLANQDIWVGNWAGDFYQGRGVPGESDSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P2</accession>
    <name>R4W8P2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445688.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04215"/>
    <dbReference type="EnsemblBacteria" id="AGN00794">
        <property type="protein sequence ID" value="AGN00794"/>
        <property type="gene ID" value="L593_04215"/>
    </dbReference>
    <dbReference type="GeneID" id="16181787"/>
    <dbReference type="KEGG" id="sali:L593_04215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.857"/>
    <dbReference type="eggNOG" id="arCOG04629">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175991_0_0_2"/>
    <dbReference type="OrthoDB" id="118704at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10791" checksum="BF1CBF6F88105700" modified="2013-07-24" version="1">MGTISARVPDDLEEQLEAYLEAEQFDRSTAVRKLLADGLDSWRKEHALDLLESGDVSFNRAAEIADLSVWDFARLAEERDVTWVGGDHLADDLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y7</accession>
    <name>R4W8Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445948.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05525"/>
    <dbReference type="EnsemblBacteria" id="AGN01054">
        <property type="protein sequence ID" value="AGN01054"/>
        <property type="gene ID" value="L593_05525"/>
    </dbReference>
    <dbReference type="GeneID" id="16181871"/>
    <dbReference type="KEGG" id="sali:L593_05525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1129"/>
    <dbReference type="eggNOG" id="arCOG04742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2802087_0_0_2"/>
    <dbReference type="OrthoDB" id="122578at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="7474" checksum="4B031E8FC7930B77" modified="2013-07-24" version="1">MVRKKKLSPSGAKDEDGEYHNVHINLHEDELAVAGMEIGDEVFVRVREDKIIIQKADQDDVEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W924</accession>
    <name>R4W924_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447187.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11750"/>
    <dbReference type="EnsemblBacteria" id="AGN02293">
        <property type="protein sequence ID" value="AGN02293"/>
        <property type="gene ID" value="L593_11750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181217"/>
    <dbReference type="KEGG" id="sali:L593_11750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2418"/>
    <dbReference type="eggNOG" id="arCOG04720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654898_0_0_2"/>
    <dbReference type="OrthoDB" id="24364at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="439" mass="47856" checksum="3D06F1D6D55281DB" modified="2013-07-24" version="1">MEQYDRLYRLYSEFDTERLRDHQAFVDLFPPLDSRVALQHWQEVSDALAEQRAEIVEAFTTDAPRSLATRPDVAAITEEAGQVYADIAAKASRDQAFTALDLLRTYERPVNVLVLDVDETLRSAGSTDNEIPREVLHLLTEFHEAGVPIVICTGQTLENVKGFLIQGLGSELVHSGTCSIVYESGNGVFTPGHGADSKQLLYEDLDDTVIAIFEGVRSRVFSDAAPETRRGCHLQGNEFNVTIKPNAATGSERARALIDDALVHQLDVLGAVAADQLDGDLDLDPVVAGEWARATYAAADPEIRGVLESRDAVPDRDLGNAPPALASLFERIDVAYYEADAAELTSRELTKPDGVDAAYDVLGIDDPFALVMGDSKTDLRVMQWAATEDAGIAAAPEHASPDVLEHVRSTDELVFDRGHAADTLRVAYALNRLAELEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W939</accession>
    <name>R4W939_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447232.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11975"/>
    <dbReference type="EnsemblBacteria" id="AGN02338">
        <property type="protein sequence ID" value="AGN02338"/>
        <property type="gene ID" value="L593_11975"/>
    </dbReference>
    <dbReference type="GeneID" id="16182258"/>
    <dbReference type="KEGG" id="sali:L593_11975"/>
    <dbReference type="eggNOG" id="arCOG01824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145174_0_0_2"/>
    <dbReference type="OrthoDB" id="106000at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="15157" checksum="C64E0F134DAA87C6" modified="2013-07-24" version="1">MGFSVSGATAVILIGGLIAFSFAFSAVNNGYERVSEAQEDREDRQLMQANSDVGIANATYDSGTSTLTVNATNTGSSELVVGRVSLLVDGAYRSNVTTAIDGDATTDVFLPGEVLTMTVNQSVRPDRVKVITGTGVAAISTEVNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W942</accession>
    <name>R4W942_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447242.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12025"/>
    <dbReference type="EnsemblBacteria" id="AGN02348">
        <property type="protein sequence ID" value="AGN02348"/>
        <property type="gene ID" value="L593_12025"/>
    </dbReference>
    <dbReference type="GeneID" id="16182371"/>
    <dbReference type="KEGG" id="sali:L593_12025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2474"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OrthoDB" id="42527at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="49087" checksum="11A4323F313B97DA" modified="2013-07-24" version="1">MEVVNPATGDRIDTYDEHSREEVETALQRADDAFEDWRGQPLREREQLLANAGEVLRENEDRYAELMTREMGKPISQARSEVQKCAWVCDHYAEHAGEYLADEHHPSPPGTTVKTSYEPLGPVLAVMPWNFPFWQVFRFAAPYLTAGDVGLLKHASNVPGCAMAIQEVFAEAGYPDGVFQSLLVSSDLVEDVLEDDRVKAATLTGSGPAGRAVAETAGAECKKTVLELGGSDPFVVLDDAALDDAAETGAWARNLNGGQSCIAAKRFVVHDAVYDEFLDRFVAEIESYAVGDPMDEATDVGPQSSEGQLETLHEQVQASVDAGATVVTGGEPLDREGAYYPPTVLTDVPEGCPADSEEVFGPVAAVYRVESDGAAIEKANDTEFGLGASVWTEDRERGERIAERIDAGCTYVNQLVKSDPRVPFGGVGVSGYGRELSEAGIQEFTNRKTVWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W954</accession>
    <name>R4W954_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447282.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12225"/>
    <dbReference type="EnsemblBacteria" id="AGN02388">
        <property type="protein sequence ID" value="AGN02388"/>
        <property type="gene ID" value="L593_12225"/>
    </dbReference>
    <dbReference type="GeneID" id="16179814"/>
    <dbReference type="KEGG" id="sali:L593_12225"/>
    <dbReference type="eggNOG" id="arCOG10323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079483_0_0_2"/>
    <dbReference type="OrthoDB" id="97312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="121" mass="13873" checksum="AD8526D7D6DFD664" modified="2013-07-24" version="1">MNDREGPTESYDGSVTVRILDDDTGKRVERCSSYVEAIDIAKEHRFTDAVTKIVDKDGDTVFSSTAMDIDTWESIWKQEKLRQGVDVEDYDCPYDNVSCFAEDLCVECKMDKVQDDVRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J2</accession>
    <name>R4W9J2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="2">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truB</name>
        <name evidence="5" type="ORF">L593_13770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447587.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13770"/>
    <dbReference type="EnsemblBacteria" id="AGN02693">
        <property type="protein sequence ID" value="AGN02693"/>
        <property type="gene ID" value="L593_13770"/>
    </dbReference>
    <dbReference type="GeneID" id="16180812"/>
    <dbReference type="KEGG" id="sali:L593_13770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2817"/>
    <dbReference type="eggNOG" id="arCOG00987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_0_2"/>
    <dbReference type="OrthoDB" id="36028at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DKCLD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="35134" checksum="1DF134BF867991DC" modified="2013-07-24" version="1">MRGPPEERSDAELLSFGVVNLDKQPGPSAHEVAGWVRDAVNDALGSGELTGSRPDDPDPITGIDGAAHGGTLDPKVTGCLPTLLGDATRLAQVLHRGAKEYVAVLELHADPPTDLEAVVSEFEGPIYQKPPRKSAVKRQIRVREIYELDVLEVRDRQALLRIRCEGGTYVRKLCHDLGLALGTGAHMGHLRRTGTTPFDDSDLVSMAELVDALAYARETADASDGSEDRDPAPIELRDVVDPAERALENLPSVTIAPSAAEQVAEGAPVYAPGVLGGPNGGNQGAELEAGDAKTEAPLVGCYTPDDAVVCLGRLVGDPDADEGLAVELERVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K6</accession>
    <name>R4W9K6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ORF">L593_13995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447632.1">
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</entry>
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    <accession>R4W9K9</accession>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="247" mass="27078" checksum="370BCDC32B1E623C" modified="2013-07-24" version="1">MRSSEAATGSRLRTLTSSDGLPERASLPWYLAPVPERLENLGLRLAWAVVVTNLLGTAFGFWYYRAQFGETPTPMWPFLPDSPMATLLFAAAVASWKLGRNRQWLIALAFVGNIVLGAWTPFVLLTFRAEFPVSPPMWQFLFWSHLAMVVQAFVLHRIGDFPPRAIAVAVLWYGTNLVVDYFVPVLGDHPHHTALPVEPEYPVALGASAHDAAGAAALVLVLFAVSVAMATGSAKRRGHETAAKRLD</sequence>
</entry>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15167" checksum="934B3591CFF357DF" modified="2013-07-24" version="1">MARSRPVAAAIGAVGLVLGWAFLQAMTPRTMPDTQPYVETMSFALSTPAGLVFLTYLTAVFDFETYYGERGWPGLFGDFFLTVLTAAAVGIPATAIVVEVTTARQVLFVVSSFATFVGGFGFFYLRTRRYFVWETDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L6</accession>
    <name>R4W9L6_9EURY</name>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ORF">L593_14145</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02768.1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33905" checksum="FD75C15039FC481A" modified="2013-07-24" version="1">MQGKRVLVTGGAGFIGSNLANHLAADNEVIAVDDCYLGTPDNLSDAVDFREQSVLDEDLPTDGLDVVFHIAALSSYKMHEENPTQGARVNVEGFVNTVEQARDDGCDTIVYASTSSIYGDRTEPSPEDMPVEVNTGYEASKLARERYAEYFHNHYDLSMAGMRFFSVYQGMAEGAEGHKGEYANLIAQFADDIANGRRPEIWGDGTQTRDFTHVDDIVNGLVLAAEHELNGIYNLGTGEQYSFNHLVDALNEELGTDVEPVYEENPIPEEIYVHDTMADPTKMHEATGWEPAIDFEEGVARVCDQYT</sequence>
</entry>
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    <accession>R4W9S6</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="AGN02953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="49" mass="5364" checksum="426C96858969B229" modified="2013-07-24" version="1">MPSCDHCNGHVSERFARVFETDDGSIEACPNCSANAGIAEQSRRRHATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z6</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="158"/>
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            <position position="47"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="17020" checksum="800004B19BBD7CC9" modified="2013-07-24" version="1">MPADGDVAPEFTAPLATGDIESFSLSDALEHGPVVLAFFPGAFTSVCSHEISAFDDRLGEFEDAGAQVVGVSRDTPFSLNEFRQELGVAVDLASDLNRDAIEEYGIEMDFDELGVYGVAKRSVFVVDTDGEIAYEWVSDDPGVEPDYDEVLAAVEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA02</accession>
    <name>R4WA02_9EURY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">L593_10770</name>
    </gene>
    <organism evidence="4 5">
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02099">
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        <property type="gene ID" value="L593_10770"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="26848" checksum="D68040D38D45DACD" modified="2013-07-24" version="1">MLLVRDDREYLLAPGERLETDLGILEVPSDPTSGETVETHIGEAFTIREPRLPDFFDHFERTGAPMMPRDAGLVLGETGAGSGDRVLDAGTGTGVLAAYLANAGADVLTYERDEGFAENARENFERADLADAVEVRAGDLTDEIDSLLEEGTADDGDASVPFDVLTLDTQDAPAVVERSPELLVEGGALAVYSPFVEATREVVEAARAAGLREIRARETIQRDLDVDERGTRPSTRGVGHTGYLVFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA27</accession>
    <name>R4WA27_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02224">
        <property type="protein sequence ID" value="AGN02224"/>
        <property type="gene ID" value="L593_11395"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11395"/>
    <dbReference type="eggNOG" id="arCOG03185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463552_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="582" mass="63260" checksum="CE9095D9E2A510C7" modified="2013-07-24" version="1">MGFFAFAFAIVTAYRSPATGYEQSIYRATPTAYWAGIAVASLLGIVVAVIATHRRRDAAHLLVALAVLSVIALPAIRGYYFYGAGDSMTHLGWAKDMQAGTWEPLQSLYPGVHVGGLMVEHLTGVTLRRALLLLPLVVFPLAFVVFMSLDVSFVSDRPWAATIGLLSGLLFLPINGITVHPMAHPSSQTIMLVPLAVFLLFRHLTAPRDPVSLFSPSSVAFGIAGLAVVFYHPQETMDLVAMLIAIAFVQYAYRRWYPDHPIASHRSIRAHTVVLGIAFLVWTFRHPRARARTEYVIEQMLGEGPQTVQQAGTWSSSLQAIGGSVEVLFLKLFAVTVVFGLLAGLLGLRTLFGGSTATTRDALITYLVAGLIPPTLLMGFVFVADQGDHYFRFLGFLAVPITILGAVAIAEGVESVGVRTSGRTIAIVLCGLFAVMLIAQAAAFHQSPYMYKTNQQVTEGAVEGYETTFEYREAEMTVMGIRGGPKRYVDAIYGTEVADSTPALSSATGGVSGPVFNENLTTAYDEDVYLAMDEGDYQREVELYRGLRYSASGFERLRTDPQIDHVMANGDVDVYRIDGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA77</accession>
    <name>R4WA77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12675"/>
    <dbReference type="EnsemblBacteria" id="AGN02474">
        <property type="protein sequence ID" value="AGN02474"/>
        <property type="gene ID" value="L593_12675"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2601"/>
    <dbReference type="eggNOG" id="arCOG08972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083232_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="29350" checksum="DF4FEF22E31C9BFC" modified="2013-07-24" version="1">MLDGERGRSFDLRDREITAEDVSAAIRTESAPIDLRCAERGPIHERVGVVEPDRTYPLQAALAAVARERGLEASQGSELAEVRARLAALELPTVSLAEQRRRIADTDDAASLEEQVSTLRGQLEAARERGEDHEALAEARERAVAELAERRTERIAAEQSLDRARRSAREARDRREDRLELEDRERNLERAARRELAGELQAAFDRALDALPGDATAGESPGSVEGPAAIGALAVCRVARIRAPVVVAGDWFDAATAAAAALDAPVVLVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB6</accession>
    <name>R4WAB6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps15p</name>
        <name evidence="3" type="synonym">rps15</name>
        <name evidence="7" type="ORF">L593_13650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447563.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13650"/>
    <dbReference type="EnsemblBacteria" id="AGN02669">
        <property type="protein sequence ID" value="AGN02669"/>
        <property type="gene ID" value="L593_13650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181341"/>
    <dbReference type="KEGG" id="sali:L593_13650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2793"/>
    <dbReference type="eggNOG" id="arCOG04185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="OrthoDB" id="98179at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17603" checksum="28EBC211CCFBC7AB" modified="2013-07-24" version="1">MARMHSRRRGSSGSDRPADDEPPEWSDVDADAIEDRVVELAEQGYDPSQIGLKLRDEGVQGTPIPDVKAATGSKVTEIMENNHVENDVPEDLRHLLEQAIRLNEHMEENGQDHQNRRALQNTESKVRRLVDYYRGDEIAEDFTYTYENAVELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC9</accession>
    <name>R4WAC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447628.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13975"/>
    <dbReference type="EnsemblBacteria" id="AGN02734">
        <property type="protein sequence ID" value="AGN02734"/>
        <property type="gene ID" value="L593_13975"/>
    </dbReference>
    <dbReference type="GeneID" id="16182503"/>
    <dbReference type="KEGG" id="sali:L593_13975"/>
    <dbReference type="eggNOG" id="arCOG01958">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="237" mass="24842" checksum="98CFAC4C08EBE093" modified="2013-07-24" version="1">MSEQESSKSVFESSDDSEPIDSATGEARTDEPGPAGSLDDSEVDDPPSDSLDENAAADPFDETVAADPPADPLDDTVVGDPLDETVEPGSHVVVVGYDGWTPAVLTELEVLDVSVSVITRRESASEGLAERPVSVVPTDDVNEACFREAGIDRADAVLVATLDDQLNVLAVLTVMNVDESMHVVTFAGEEEDVPKLRAAGADRVVSLGQAVGELLVEVALSERQVDDVVAQLLGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSD4</accession>
    <name>R4VSD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445019.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00850"/>
    <dbReference type="EnsemblBacteria" id="AGN00125">
        <property type="protein sequence ID" value="AGN00125"/>
        <property type="gene ID" value="L593_00850"/>
    </dbReference>
    <dbReference type="GeneID" id="16182194"/>
    <dbReference type="KEGG" id="sali:L593_00850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.174"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_0_0_2"/>
    <dbReference type="OrthoDB" id="53692at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="29500" checksum="6CFA71276AAC8A31" modified="2013-07-24" version="1">MASLRDLGLSEYEARAYRALLNTGPATAKELSRASDVPMGRIYDVLNSLEQYNLVRSQTASRPKKYVAVEPATALDRLLEDKKRELDAQAEQYEEIVDDLSVELDAAEPVEEQFWTAAVGAENAVDLLIERLAAAEDRIVVVGSDRSPLFDVSELGILAVDELESALDRGVTIEVLLTPGLVDSLPPEVGNRHRRTLSEHPRYEVRTAPNVAGTFNLIDATEVTIHVPHPLEPDEPFGVIDLKDPEFAADVQELYGPRWEAAEPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT05</accession>
    <name>R4VT05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445219.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01870"/>
    <dbReference type="EnsemblBacteria" id="AGN00325">
        <property type="protein sequence ID" value="AGN00325"/>
        <property type="gene ID" value="L593_01870"/>
    </dbReference>
    <dbReference type="GeneID" id="16179935"/>
    <dbReference type="KEGG" id="sali:L593_01870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.379"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="518" mass="53783" checksum="C9DDBBC8BDD4879E" modified="2013-07-24" version="1">MGGQPLFILNEDSSRTSGRDARQANISAGKAIAEAVRTTLGPRGMDKMLVSDGDVVITNDGATILEEMDIEHPAADMIVEVAQTQQEEVGDGTTTSAILTGRLLAQAEDLFDDDVHPTTIVEGYHAAAEIAAEAIDDVAIDAAIDEDVLRTVAESSMTGKGTGGVTAESLAKVVVDAVTQVRDGDDVSRENITVHTQAGASSAATELVEGIVLDEEAAHGQMPKTVEDASVAVLDVELGVRTGDVDAEYTVESVDQLTKAMEAEEGELRKHVEALSDAGVDVVFTTEDIDDRVAAQLGRAGILAFESLSGSDATAVANATGASRVGDLDDLEEPDLGHVETVRAETYEDDELAFVEGGAAAKAVTIFCRGGTEHVVDEVERAIEDALDVVTAAAESGEVVPGAGAAEIAIADRVREESASVEGRKQLAVDAFADAIDAIPRTLAENAGADPIDTLVDLRALHDSEGRAGLIAEDREAEVGDPVEHGVLDPAAVKQEAVESATEAATMIVRIDDVISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT14</accession>
    <name>R4VT14_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylallyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445229.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01920"/>
    <dbReference type="EnsemblBacteria" id="AGN00335">
        <property type="protein sequence ID" value="AGN00335"/>
        <property type="gene ID" value="L593_01920"/>
    </dbReference>
    <dbReference type="GeneID" id="16179986"/>
    <dbReference type="KEGG" id="sali:L593_01920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.391"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="38493" checksum="9216D61C3876687D" modified="2013-07-24" version="1">MSDPEAREAAVLATIRERREIVNEAIPEEIPIQTPERLYEASRYLLDAGGKRLRPTISLLVAEALADVEPGSTDYRTFPTLSAEVPEIDVLSSAVSVEVIQSFTLIHDDIMDDDDLRRGVPAVHREFDLETAILAGDTLYSKAFEIMLGTGAADERSVRALDVLARTCTEICEGQALDVEFEDRGDVAVEEYLHMIEQKTAVLYGAAASLPALLMGADDETVDALYQYGLDVGRGFQIQDDVLDLTVPSEKLGKQRGSDLVENKRTLITLHAREQGVDIGTLVETDSVEAVTEAEIDDAVATLQEAGSIEFARERAEGLVESGKAHLEVLPDNEARELLEQTADYLIERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT19</accession>
    <name>R4VT19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445234.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01945"/>
    <dbReference type="EnsemblBacteria" id="AGN00340">
        <property type="protein sequence ID" value="AGN00340"/>
        <property type="gene ID" value="L593_01945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180956"/>
    <dbReference type="KEGG" id="sali:L593_01945"/>
    <dbReference type="eggNOG" id="arCOG06259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084122_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="288" mass="30476" checksum="C972C634B0331598" modified="2013-07-24" version="1">MIAIAGGKGGCGKTTTTLGIARSLEASGIGGRAIDLDAGMPNLHRMADVDREPPLAALVDEEGGAEIQRDSHGVEIVPAPRALAALDLSSALDAVQPRDGVALFDCPAGAGPAATAPLREAEAVILVSTSREESVEDAAKTGRMARSLGVPVLGAVVTRTQRVSRGVASELAAEQTVAIPTRGEPLTDDRVRECYDAVAGWIETWLQRRGREKYSEAERSDTTVTVRKPAIRGDRSESRTCPCCGGIRPARSSDERATDRRDRRSRRSRAARGTRSSWRGGGALSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTA1</accession>
    <name>R4VTA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445334.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02445"/>
    <dbReference type="EnsemblBacteria" id="AGN00440">
        <property type="protein sequence ID" value="AGN00440"/>
        <property type="gene ID" value="L593_02445"/>
    </dbReference>
    <dbReference type="GeneID" id="16180215"/>
    <dbReference type="KEGG" id="sali:L593_02445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.496"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="263"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="390" mass="40174" checksum="73F2180EEA07E51A" modified="2013-07-24" version="1">MRDAYLVGAGQTAFGSMPSESYRSLFATAFDRAIDSVPGGLDPRSIDEAVIGALGVGGRQLGLAGPAITEHLGLHGVPCSRIENACAASGYAVRQAVQAVQSGMADVVLAGGVEVMTDLSDDVTNYWLGVSGETEWERLTGTTFAGVYAQMASAYLDRYDATAEHLSMVAVKNHANGAKNPHAHLGFECSLEDATGAPTVAEPLTLYHCCPTSDGAAAVLVASEDVVEEYTADPVRIAGVGAASDRVGLFQRDTYTGIPASELAANRAYEAAGIEPDDLDVAEVHDCFSIAELLAYEDLGLCDRGEAHTLLEEGTTDPDGAIPVNTSGGLKSKGHPIGATGAGQLGECYHQLTGEAGDRQVEDAEIGLAHNVGGSGGAAVVHVLEREGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTD4</accession>
    <name>R4VTD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445369.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02620"/>
    <dbReference type="EnsemblBacteria" id="AGN00475">
        <property type="protein sequence ID" value="AGN00475"/>
        <property type="gene ID" value="L593_02620"/>
    </dbReference>
    <dbReference type="GeneID" id="16180282"/>
    <dbReference type="KEGG" id="sali:L593_02620"/>
    <dbReference type="eggNOG" id="arCOG09354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206907_0_0_2"/>
    <dbReference type="OrthoDB" id="125594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7033" checksum="CBD2A56AD9E51213" modified="2013-07-24" version="1">MSEPTSEEGFFSFGIANWITIGFVVLGVASWLLARSITDSAVVLYGALIGVGVIAPTLVNEWRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTI9</accession>
    <name>R4VTI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02970"/>
    <dbReference type="EnsemblBacteria" id="AGN00545">
        <property type="protein sequence ID" value="AGN00545"/>
        <property type="gene ID" value="L593_02970"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02970"/>
    <dbReference type="eggNOG" id="arCOG06293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478957_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="191" mass="19866" checksum="5EE725FA39F931DE" modified="2013-07-24" version="1">MTRVDRRRIHGVAVALRDALVYPLTSDARLLGAGVVTIGTYVLLVLSTYPQFTRQFLERDLTDVTYGVSVLTREVYLTSGWLGLSLVVLYALLTGVAVTNAAALLRRRRRSGATGVAGILPGVLAAGCASCGAGVLGALGFVGAMAALPYDGTLLRVGGIVLLVGFLTRSGDPRTCSVGAIERTEPDGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUD1</accession>
    <name>R4VUD1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_04295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445704.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04295"/>
    <dbReference type="EnsemblBacteria" id="AGN00810">
        <property type="protein sequence ID" value="AGN00810"/>
        <property type="gene ID" value="L593_04295"/>
    </dbReference>
    <dbReference type="GeneID" id="16180897"/>
    <dbReference type="KEGG" id="sali:L593_04295"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.874"/>
    <dbReference type="eggNOG" id="arCOG04733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_4_1_2"/>
    <dbReference type="OrthoDB" id="113131at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RLI" evidence="9">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Ribo_biogen_C" evidence="8">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="18942" checksum="05D3135349F214D7" modified="2013-07-24" version="1">MADSLALHARYEGDDDPKKCTARRLEREGALELHRSDRETPYGIVLNPHSEQALSPADRGLAERLVALDCSWETAEAAQFSIAGEHRALPFLVAANPVNFGKPFQLTTAEALAGGLAILGERQAAEELLEIFSWGEAFIEMNDEPLRRYAACADSSEVVAVQEEYLADPDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUF9</accession>
    <name>R4VUF9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445739.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04470"/>
    <dbReference type="EnsemblBacteria" id="AGN00845">
        <property type="protein sequence ID" value="AGN00845"/>
        <property type="gene ID" value="L593_04470"/>
    </dbReference>
    <dbReference type="GeneID" id="16180959"/>
    <dbReference type="KEGG" id="sali:L593_04470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.911"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_2_2"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="57"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="33135" checksum="6273192E09B9B664" modified="2013-07-24" version="1">MGTVVSLGSANVDKIQHASDVEITDCSDRYRWFPDRGQTVQIRDLPTEFAPDPDGVRHGGKGANQAVAAAKAGAEAELLGKVGPDSEDFGVRSHLAEAGVGVSRVETASAPTGTAHVFVGPAGDNRIVVRPGANDAIDSAYVREQYDAIRSADCLLLQNEIPVEPVAELLSELAADRDRPTVILDPAPADGVEALLDCDAIDYLVPNETEYRALRSTLEAFDGVLVRKRGADGVVVEAKRRFTVPPPTVEAVDTTGAGDVLNGFLAAQLAIGASLQDAVEIGTIAGALATRETGARRGIPTLEDVRTYRTDDGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUQ2</accession>
    <name>R4VUQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_05030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05030"/>
    <dbReference type="EnsemblBacteria" id="AGN00955">
        <property type="protein sequence ID" value="AGN00955"/>
        <property type="gene ID" value="L593_05030"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1025"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_10_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="9">
        <location>
            <begin position="417"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="10">
        <location>
            <begin position="550"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="634" mass="67281" checksum="873B5390AAEADA55" modified="2013-07-24" version="1">MLSAIAATPLAASGGNTLILVAIILALGVTAQLLGDAFQVPSVLFLIIAGILVGPEVIGLVTFADLEPALRTIVGVSVAIIVFEGAFHLKLEKVREAPSAALLMVTLGAAISFVGTTVAVQFLLEPGWGIAATVGALLIATGPTVITPILSVVPVRDRVAAVLETEGIVNDVTAAILAVVIFELLASQETYPTDFLYEFLERLSVGLVVGIATALVIWYLLEHVDVGTGWTPQSARLMTLAGAVLAFAAADQISTEAGVAAVAAAGVLLGNLDLPFEEEIEEFKGDITLIVLSFVFIALAALIEFDVLVDIGIAGLLVVLVVTLVLRPLLVFLSTIGDRFTFQERLFISFVGPRGIIPASVATLFAIQLQDPTVAPTDVYGGEVLAGTVFLAILLTVVFQAGLARQIAEKLNVVPMRVLIIGGGRVGLALAERLEERGENIVLLEEDEEKIDQLRADGYTVRQGDGTDIEFLEASGAGNAKILVAATGDDDTNLLVAQLASSKFDVETVITRVNQPENVDAFRELEVETVDASMATAWAIDNSIERPALSNWMNELGRAGDVQEIEVTDRSLEGRTIRELDEELPNGCILALVSRGDENEIPDPDFEIECGDHLTVLGRTEDVRQALKILHPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUT5</accession>
    <name>R4VUT5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444920.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00026">
        <property type="protein sequence ID" value="AGN00026"/>
        <property type="gene ID" value="L593_00355"/>
    </dbReference>
    <dbReference type="GeneID" id="16180625"/>
    <dbReference type="KEGG" id="sali:L593_00355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.71"/>
    <dbReference type="eggNOG" id="arCOG03118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_5_1_2"/>
    <dbReference type="OrthoDB" id="89753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="237" mass="25775" checksum="556ABC2229BDD24C" modified="2013-07-24" version="1">MAPSRPPQVFRSGTARRRFLFHAVIATVAALSAFVVIVDRYQFLLDPIQARGFVSDFGVFAPLALVLLQALQVVAAPIPGQVLAVVAGYLFGPWWGTLYNMTGIMIGSTVAFWLSRRFGRSYVEAMVHPDLIETFDDIEEDNVMAALFVLFLVPGMPDDVLCFVGGLTDVRLRKLVLVALVGRTPAFFVVNVLGDQLGAGEIGIATGLAIAMLVVSGLGYIYRGRVLSWLEQKDLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVD5</accession>
    <name>R4VVD5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_06205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06205"/>
    <dbReference type="EnsemblBacteria" id="AGN01190">
        <property type="protein sequence ID" value="AGN01190"/>
        <property type="gene ID" value="L593_06205"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1267"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_8_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="3"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="7">
        <location>
            <begin position="499"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="7">
        <location>
            <begin position="637"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="786" mass="84494" checksum="7B3000BBD003E202" modified="2013-07-24" version="1">MFDITMIGIGAMIGAGIFVLTGLAAGQAGPGLVMAFAFNGFITIFTGMVYAELGSAIPEAGGGYLWVREALGRSQAFLAGWMSWFAHAVAGSLYVLGFGAFVHLLLTDYFGIQLFQPIDLLFITFGPEKLFAVFAGALFAYINYRGAKETGLAGNIVTMVKVTVIVVLIAFGFGYILGNPGQSTERFRPFLPRDFGGVFIAMGLTFIAFEGYEIIVQSGEEVVNPKKAVPKAVFYSMSVVVTIYMLVAIVLIGAVSVTPELFSLAQEGAASGGHGATNLPPVPDDIADAAVWEILGHLGELGLARAAGQIMPYGTLVILVAGIFSTLSALNATTYSSTRVSFAMGRDHVLPDAFSAVHPEKKTPHIATALSGALIVFMAVALPIEAVAAATDVMFLLLFLQVNYAAIVIRREWGDQIDYGYVMPFFPYVPIIGILTKLALAVYLFNYSPLAWYGAIAWILVGVGIFFLYSRSRVRETEAKEETRLIAEERSPEERGYQVLVPIANPDHAEQLIRAGSAIARRQDGEVLLTSVATVPDQTPLSEGSRYADEQRELLDEAMQYAPEDVPVHQTVTIGHDIAKSINNVAYQRDSDLVLLGWRGQRKRMSDYALGSNIDTVVENAECDVAVLKTDGTTDSRRVLVPTAGGSNSDLAEMVAAAYVEAGSEVTLFHVATDRDVESAQSFLEQRQAALAESDIDVDITVEAGEDISEGILEYARNGDFDSIIVGAAGEGILRRVLFGEVPETVGAEFEGEVVMVRKHRPVQSAVKRLVGKWVGKGAKATNLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVE6</accession>
    <name>R4VVE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445100.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01265"/>
    <dbReference type="EnsemblBacteria" id="AGN00206">
        <property type="protein sequence ID" value="AGN00206"/>
        <property type="gene ID" value="L593_01265"/>
    </dbReference>
    <dbReference type="GeneID" id="16182617"/>
    <dbReference type="KEGG" id="sali:L593_01265"/>
    <dbReference type="eggNOG" id="arCOG04764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128026_0_0_2"/>
    <dbReference type="OrthoDB" id="105234at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043851">
        <property type="entry name" value="DUF5813"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19130">
        <property type="entry name" value="DUF5813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="18881" checksum="2C19478EA3AB881B" modified="2013-07-24" version="1">MNDESNDAAGRAFDANPAFERSADGYAVTTTPFEATVRAESIDHEGRDARFHVEVTMPSLDAAVADERVGDVVQDGWFETLALRLEDAYDVAEVDAASDPEIALRDSTVEARFSFLAWNADTGVADAKAIVDFAEGTYVQGVVPGYQYDDPVAGLIDRATQQAGSEDSGAKRGGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVI7</accession>
    <name>R4VVI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445155.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01540"/>
    <dbReference type="EnsemblBacteria" id="AGN00261">
        <property type="protein sequence ID" value="AGN00261"/>
        <property type="gene ID" value="L593_01540"/>
    </dbReference>
    <dbReference type="GeneID" id="16181981"/>
    <dbReference type="KEGG" id="sali:L593_01540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.313"/>
    <dbReference type="eggNOG" id="arCOG02331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="38153" checksum="3F972A17A572E5E7" modified="2013-07-24" version="1">MSADDTSHPDLRGYIESSPDAIVIADPEAASIVEASEAAETFFGYSQAELRTMSVLDLHPPDERDRYRQLFEDHLENQPAVVSQFDDGDQVFVQTADDRRVPVEINAWTIDHDGRDSSLFQGIFRDVSGRLRRRRALQRQNERLEEFATVIAHDLRNPLNVARGRAVLLAEEGDGEHLEPLQSALDRIETIVDDTLTLARNGKRVGDLEPVNAVDAIGECWRSIETDDASLEIDDEFTIAADPDRLRHVFENLLRNAVQHGGDGVTVSVGRADERTMYVEDDGVGVPDGERDDVFAFGHSSRPDGTGMGLTIVRRLADAHGWTVSVTESDEGGARFEFGDVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVN9</accession>
    <name>R4VVN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446159.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06590"/>
    <dbReference type="EnsemblBacteria" id="AGN01265">
        <property type="protein sequence ID" value="AGN01265"/>
        <property type="gene ID" value="L593_06590"/>
    </dbReference>
    <dbReference type="GeneID" id="16181832"/>
    <dbReference type="KEGG" id="sali:L593_06590"/>
    <dbReference type="eggNOG" id="arCOG03658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072736_0_0_2"/>
    <dbReference type="OrthoDB" id="36566at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="33293" checksum="826CC42409C54ABB" modified="2013-07-24" version="1">MSNVASPPTGIDRDHRSYQYYRTEVERHWDPADVALEDDVEALVDAPAAVLDGLRDALAKFGAGEQSVTADLAPLGVVLDGIEDQSFLATQCYEEAKHADFFDRYWREVIRQVERERDVAVSSPTDERWFDPDYETLFDRQETYLHALLDEDTPETRARAYSVYHLVVEGIFARTGYYGLRTVYGDESDETPTLPGLVEGVRLIQGDEGRHVGFGIAKLRELVHERGVDPSLIEETVGELATLVQGSLAATMEQTEGAIPEAVDVDLVEYALEKHGERMTQITATDRSTADQPPGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVS7</accession>
    <name>R4VVS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation-associated GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445255.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02050"/>
    <dbReference type="EnsemblBacteria" id="AGN00361">
        <property type="protein sequence ID" value="AGN00361"/>
        <property type="gene ID" value="L593_02050"/>
    </dbReference>
    <dbReference type="GeneID" id="16180573"/>
    <dbReference type="KEGG" id="sali:L593_02050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.417"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OrthoDB" id="51913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="42970" checksum="71FF5A845608E027" modified="2013-07-24" version="1">MSYRIGLVGKPSVGKSTLFNAATMNDVPEGAYPFTTIDPSIGEAYVRTPCAAPEFEESCQPSVGACEDGTRFVPVKLVDVAGLVPGAHEGKGLGNQFLTDLNETDVLVHVVDFSGTTDLEGEPTEGHDPRDDVDFLEAELDAWYLDILEKGIERYESKHMADPDPEAVLAEQLSAFGIVAAEVKQVILALGLEVAPLSWDDEEKEELAREIRKRTKPMVVAANKMDTAAAQENWEAITTDPDYDHLEFVPVSAHAEKALKSAKEQGAVDYTPGEDHFEITADLPADQEAGLEQIREFVESFDGTGVQQALETAAFDVLDLKAVFPGTDSGNWTKGPFRDCFLLPADATAEEFAYHLHSDIGDGFLHAIDCRDSRQVSADAVLDHRDVVEVVSTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWM6</accession>
    <name>R4VWM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemD</name>
        <name evidence="2" type="ORF">L593_03650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445575.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03650"/>
    <dbReference type="EnsemblBacteria" id="AGN00681">
        <property type="protein sequence ID" value="AGN00681"/>
        <property type="gene ID" value="L593_03650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181336"/>
    <dbReference type="KEGG" id="sali:L593_03650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.741"/>
    <dbReference type="eggNOG" id="arCOG02048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_2"/>
    <dbReference type="OrthoDB" id="106625at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="25856" checksum="8A07A6110600C502" modified="2013-07-24" version="1">MTSTPTVAVFRPDDERIDEAVTALTEAGLDPVADPMLAIEPTGAIPRVEAADVVIFTSKTGVELVAEAGWSPPTDATIAAIGDATETALRDAGYEVDLVPEEYSSRGLVDALTSAIERGEVESIEVARSDHGSDVLLDGLAAAGATVQETVLYELRRPADAGESTELAAEGSLDGACFTSSLTVEHFLAAAADRGLEAAARGGLETAVVGAIGEPTAETLRERGIAVDVIPATADVDVLVDDVAAAIEARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWT4</accession>
    <name>R4VWT4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_03775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445600.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03775"/>
    <dbReference type="EnsemblBacteria" id="AGN00706">
        <property type="protein sequence ID" value="AGN00706"/>
        <property type="gene ID" value="L593_03775"/>
    </dbReference>
    <dbReference type="GeneID" id="16181930"/>
    <dbReference type="KEGG" id="sali:L593_03775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.766"/>
    <dbReference type="eggNOG" id="arCOG00607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_1_2"/>
    <dbReference type="OrthoDB" id="51079at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="255"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="318"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="391" mass="41882" checksum="16A6641CEB6CC7F4" modified="2013-07-24" version="1">MRSLTIGRVLDIPIRINVSLLLFLPILVWLIAGQIELYADVVNAVSPTTVDAEVLTEGETPWIIGVVAAVGLFVGVLLHELGHSVTAMRYGIGIASITLWIFGGLARMEDLPEDWSIEFWVALAGPVTSVALAGICYLALFAIPSSAPAVLIFVVAWLAVINLTLAIFNMLPAFPMDGGRIFRALLARNRPYVEATAIAAKTGRFFGVAMVLVGVLNFAPLLALVGFFVYVAAGAESRVVTLRDLLRDVRADDLLQTDSSTVGTDTTVQDLLQRMFEDRRTGYPVLDANGRLAGLVSLGALRSVPPADRSTVTVADVMSRDPPTVSIETPAFDVLERLAETGSDRVVVLEDDRLVGTLDNEAIVAYIDLVQGIGPLPETETPDATPPDGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWU0</accession>
    <name>R4VWU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445605.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03800"/>
    <dbReference type="EnsemblBacteria" id="AGN00711">
        <property type="protein sequence ID" value="AGN00711"/>
        <property type="gene ID" value="L593_03800"/>
    </dbReference>
    <dbReference type="GeneID" id="16180116"/>
    <dbReference type="KEGG" id="sali:L593_03800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.771"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_2"/>
    <dbReference type="OrthoDB" id="36944at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="317" mass="34321" checksum="1EB49CBA376DC50E" modified="2013-07-24" version="1">MSDLVTFGETMLRLSAPQGERLERTEELDVYVGGAESNTAIAAERLGAVSTWLSALPDSPLGRRVAAELHSHGIDTEIVWSDDGRQGLYFVEHGGEPRGTNVIYDRADAPIASVGADQFDPAVFDDARLFYTSGITPALSEQARDTTYHLLQGAREAGLRTAMDLNYRSKLWTPEEAKATLTKLFPALDVLFVANRDARTVLGYDGNATEFANHLIAEYDLQTVVVTRGEHGALAIHDGVVHEHDVYEADTYDPIGTGDAFVGAFLARRLSGDDVGRALEYAAATASYKRTIAGDVAAVTKEEVEELIESGAEDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX03</accession>
    <name>R4VX03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445685.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00791">
        <property type="protein sequence ID" value="AGN00791"/>
        <property type="gene ID" value="L593_04200"/>
    </dbReference>
    <dbReference type="GeneID" id="16180865"/>
    <dbReference type="KEGG" id="sali:L593_04200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.854"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_2"/>
    <dbReference type="OrthoDB" id="62488at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="28261" checksum="194EAF8CCF90D47B" modified="2013-07-24" version="1">MTVTETFVDLVGTDPVVQGLVGGLVIAGMNLVGASLVMVWRDPSDRALDAALGFAAGVMLAAAFTSLIIPGIEDYAGGDPIPVLVGIALGAAFLDQADGLVPHAHYLLTGSRRTDAANPSETLPLDEERLAPVVLFILAITLHNMPEGLAVGVGFGSGDVDTGISLMIAIGIQNIPEGLAVSVAAINAGLDRNFYAAFAGVRAGVVEIPLAVLGAVAVSQVEPLLPYAMGFAAGAMLFVISDEIIPETHIRGHERLATLGLMAGTIVMLFLDVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU5</accession>
    <name>R4VXU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10750"/>
    <dbReference type="EnsemblBacteria" id="AGN02095">
        <property type="protein sequence ID" value="AGN02095"/>
        <property type="gene ID" value="L593_10750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10750"/>
    <dbReference type="HOGENOM" id="CLU_2893416_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6741" checksum="3C7F6785FE7C8EB1" modified="2013-07-24" version="1">MPRDWLLARMGLAAYVGASSDEDRLASLGSPARARADADHRDFVMPGFSSGWDWKGPTGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY04</accession>
    <name>R4VY04_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446035.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05960"/>
    <dbReference type="EnsemblBacteria" id="AGN01141">
        <property type="protein sequence ID" value="AGN01141"/>
        <property type="gene ID" value="L593_05960"/>
    </dbReference>
    <dbReference type="GeneID" id="16181562"/>
    <dbReference type="KEGG" id="sali:L593_05960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1221"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_0_0_2"/>
    <dbReference type="OrthoDB" id="116879at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="36239" checksum="D6E76FA0770960E0" modified="2013-07-24" version="1">MTEDDAEAAEDAAEEAAEAEAEDNGDEESGLQEGDFVRLSYTARETQDGGLVDTTSQEVAEEEGVADEDQTFEPRIIVLGEGHLFEPVEEAIKGQEEGDSGTVTVPAEEAFGEKDPEQVRTVAADKVPEDERYPGAHVQIDGEHGHVEAIIGGRARVDFNHALAGRDIEYEYEILDVVDDRLERAQGLVNAFLDIDLEMWFETDEVEEETYVSPSEEEGEDEDTEGDEDEDVEGHFETELVEKESLYIEATPQLTMNQQWMMGKQQIAQQLIDRLGIDRVVVQETIDGMGAGPMGGMMGGMGGGGEGDIEDALEDADVDADELVEELEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYC2</accession>
    <name>R4VYC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11560"/>
    <dbReference type="EnsemblBacteria" id="AGN02255">
        <property type="protein sequence ID" value="AGN02255"/>
        <property type="gene ID" value="L593_11560"/>
    </dbReference>
    <dbReference type="GeneID" id="16182314"/>
    <dbReference type="KEGG" id="sali:L593_11560"/>
    <dbReference type="eggNOG" id="arCOG01075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_16_2_2"/>
    <dbReference type="OrthoDB" id="116493at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19924" checksum="1D80CBFCA4198142" modified="2013-07-24" version="1">MSNFPPEYCPYCGSELDEVEPPTSHYCGRCEDYVFYNPTPGGSVAVVDGDRLLLVEDFRYENEWKLPSGVLESGESPAEGAIRELAEETGLSVAPSDLAYVTNNAVEPVEGKHHANVTFAARRAATTGTVEAGSDATDARFWSPVEFADAEARFTDVHRRRFGSDSLAWLHETVESALVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYG0</accession>
    <name>R4VYG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06570"/>
    <dbReference type="EnsemblBacteria" id="AGN01261">
        <property type="protein sequence ID" value="AGN01261"/>
        <property type="gene ID" value="L593_06570"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1340"/>
    <dbReference type="eggNOG" id="arCOG02936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="356" mass="39015" checksum="833B7DC7BA133C0B" modified="2013-07-24" version="1">MGAERVTARLPSSDLEWCHDAVQDVSRTFALTVDVLEEPMSSQICLGYLLCRVADTIEDASHLPPAEQVALLDRYDAALSSDTDVTMAQFRSEVDEWLPSPAERNADWSVVANVPTVWATFEERPEAVRCAVVPPVREMVTGMGQFIERYEDAGGLRIADRAELESYCHYAAGTVGTLITNLLTRGDVGQDRSRQLYDTAGAFGLLLQLVNVSKDVYADFHEENNVYLPAEWLDAAGVEQDAVLDPDNRDAVATVVDRTAAFAQTFLDDAQSYLETAPMAFGNTIAAWSIPYLLSVGTLRELRDRPKDALTDGGVKVSRQEVLAVVHAANGTSPAGLSDLRETIAREPFHLASTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYJ0</accession>
    <name>R4VYJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase, subunit M/transcription elongation factor TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446190.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06745"/>
    <dbReference type="EnsemblBacteria" id="AGN01296">
        <property type="protein sequence ID" value="AGN01296"/>
        <property type="gene ID" value="L593_06745"/>
    </dbReference>
    <dbReference type="GeneID" id="16181855"/>
    <dbReference type="KEGG" id="sali:L593_06745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1378"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OrthoDB" id="121393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOL9" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11640" checksum="A542519E852BA0AD" modified="2013-07-24" version="1">MQFCDACGSLMHTEGDTWVCRSCEHEEPRDSQAEAAMATQDRQRDDGAPDVADATQDAPETMQEPCPATDCNSDRASYEMMPKPGGSYEVRLFTCVACGHKWRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYS1</accession>
    <name>R4VYS1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein Crp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447304.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12355"/>
    <dbReference type="EnsemblBacteria" id="AGN02410">
        <property type="protein sequence ID" value="AGN02410"/>
        <property type="gene ID" value="L593_12355"/>
    </dbReference>
    <dbReference type="GeneID" id="16181944"/>
    <dbReference type="KEGG" id="sali:L593_12355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2541"/>
    <dbReference type="eggNOG" id="arCOG04399">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090237_0_0_2"/>
    <dbReference type="OrthoDB" id="41689at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012015">
        <property type="entry name" value="UCP_HTH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004955">
        <property type="entry name" value="HTH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="27080" checksum="B265D6E417E6F27A" modified="2013-07-24" version="1">MADVLDNKRAATRFRILVEIAERQPAVSQGEIAEAVGVTSQAVSEYIRELVDDGLVEMEGRSRYRVTKEGVDLLLRDATEVRRFVDHVTEDVLGSVQEDAAIATDDLEEGETVTLSMRDGLFHASPGESGEATGITTTAAEAGQDVGVTGFEGVVDLEPGSVTVLQIPPIRSGGSRVVDDEAVAAAVDEAELVVAAGVEAVVALRDADAEPAVSFAGGEVAAEAAGRGLDVLVAATTDAVGRVTDALRDADVTYEVSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ35</accession>
    <name>R4VZ35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446405.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07830"/>
    <dbReference type="EnsemblBacteria" id="AGN01511">
        <property type="protein sequence ID" value="AGN01511"/>
        <property type="gene ID" value="L593_07830"/>
    </dbReference>
    <dbReference type="GeneID" id="16182243"/>
    <dbReference type="KEGG" id="sali:L593_07830"/>
    <dbReference type="eggNOG" id="arCOG01782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_1_1_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="22827" checksum="48C37EB2CA4671BD" modified="2013-07-24" version="1">MSDPDTIATYESVAVEYRERHADRSVVAEIVDAFLDALTAGTAAGPASDTNGGGEPDEPRVLDVGCGPGWESATFADAGHDVLGIDLTSEFLDAAANETAPTADFARMDMRRLGFVDATFHGLWACASFLHVPRENAPATLAGFERVLTDGGVLALSVKRGDGTRPGDGYDDDQREFVLYQPGEFRELVEDAGFTVETVDAREYWIFLLARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ97</accession>
    <name>R4VZ97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447494.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13305"/>
    <dbReference type="EnsemblBacteria" id="AGN02600">
        <property type="protein sequence ID" value="AGN02600"/>
        <property type="gene ID" value="L593_13305"/>
    </dbReference>
    <dbReference type="GeneID" id="16180520"/>
    <dbReference type="KEGG" id="sali:L593_13305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2722"/>
    <dbReference type="eggNOG" id="arCOG02749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142662_0_0_2"/>
    <dbReference type="OrthoDB" id="107911at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13588" checksum="364C8E9043EB49B2" modified="2013-07-24" version="1">MPVRIEEFEAGELPQGPSVPVQVITFLYTNRDQAFTRSEIATGIDEDPNTVGTALSRLKQRELVRHKGEYWAVIDDLERVSQAYDLHAISQRLDDEDGGIDPEKWNATAPDEPHPSERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZL3</accession>
    <name>R4VZL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446580.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08705"/>
    <dbReference type="EnsemblBacteria" id="AGN01686">
        <property type="protein sequence ID" value="AGN01686"/>
        <property type="gene ID" value="L593_08705"/>
    </dbReference>
    <dbReference type="GeneID" id="16181523"/>
    <dbReference type="KEGG" id="sali:L593_08705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1784"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OrthoDB" id="53827at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="3">
        <location>
            <begin position="26"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="2">
        <location>
            <begin position="376"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="489" mass="48443" checksum="E1E6B49C7C0CB41D" modified="2013-07-24" version="1">MDGSSPIAVRDRERFEASPAAALAVDCLLAGIEAAQPSAVIDERVSLDGATLAIDGTTYDLDAADRVLVVGGGNAAGRVASALEGVLGERIDDGIVVTDDPVPLDRVASITGAHPVPDDAAMDGANQVLDLVDGATERDLVLGVITGGGSALLPAPAGDVSLADLQDLTDALVRSGATIDEINAVRKHVSALKGGRLARAAAPATVATLVFSDVVGDDPATVASGPFSPDPTSYAEARSVLERHGIDAPGSIRRRLDRGAAAGTTGAAAETTDAAVGATDATAGDSDATAGNSDAAEAPTETPGPDEPAFDAVDVHVLASNDAAIDAAAEAARDAGFDSLVLSTRIEGEAREVGTVHAAIADEVRASGRPIEPPAVLLSGGETTVTLGDASGAGGPNQEVALAAALDLADPSTVIASVDTDGIDGATDAAGALVTGDTVGEEVSAATARAALDAHDAYPVLDDAGALLRTGPTGTNVNDLRVIVVLNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZS5</accession>
    <name>R4VZS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447649.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14080"/>
    <dbReference type="EnsemblBacteria" id="AGN02755">
        <property type="protein sequence ID" value="AGN02755"/>
        <property type="gene ID" value="L593_14080"/>
    </dbReference>
    <dbReference type="GeneID" id="16181064"/>
    <dbReference type="KEGG" id="sali:L593_14080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2881"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="47965" checksum="B703262D540D2A06" modified="2013-07-24" version="1">MAEVTLDSVTKVFQDGDDQVVAVDDVSLSIDDGEFLVLVGPSGCGKSTTLRMIAGLETVTSGTITIGDDVVNHVPAQHRDIAMVFQSYALYPHMTVRENMAFGLEESTTLERDVIDRRVEESAHMMGIDELLNRKPADLSGGQQQRVALGRAIVRDPEVFLMDEPLSNLDAKLRAQMRTELQRLQDELGTTTIYVTHDQTEAMTMGDRIAILDGGVLQQIGTPLECYHRPNNQFVAGFIGEPPMNFLNVDHEDGTLVNENVEYSLPADVEESLEPGAEYVLGIRPEDIELQIGGDGGDHLLEATVDVVEPTGDENVVYLALDEAAMGEDSDRQIAVGVGDEEPSAGGSPTGSSQSGLLGRLGSLVRGLGSRGRSSAAATSPDSEGDTADAIEAGDSSRLTATVGGMEQYESGQAVTAYLPPEAIHVFDAASSAAVHNRRLDEVDRAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W006</accession>
    <name>R4W006_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14505"/>
    <dbReference type="EnsemblBacteria" id="AGN02840">
        <property type="protein sequence ID" value="AGN02840"/>
        <property type="gene ID" value="L593_14505"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2966"/>
    <dbReference type="eggNOG" id="arCOG00196">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
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            <begin position="37"/>
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        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="308" mass="33957" checksum="FCF89E0BC2608155" modified="2013-07-24" version="1">MPPAIETERLVKQYGDLRALDEVSLRVEDGEFFGLLGPNGAGKTTFISILVGLVRLSGGSARVFGHDVVDDYREARDAIGIAPQEFNVDRFFPIKEVLMHKAGYHGIPHDAAERRAEEVLRTVGIYEKRDQRFDWLSGGMKRRLLLARALVTDPDLLILDEPTAGVDVELRHDLWEIVSDLNDAGTTVLLTTHYIEEAERLCDRVAILDHGSVVTVETPEQLMDRGTDTIYVTLDAEPDAPPALDGYVIDSWIDAGRLAVQVRDGGGTAPRLLRDLHAAGHDVVDLEIARTSLEDVFVDLTERTGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W031</accession>
    <name>R4W031_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_09455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446730.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="SMR" id="R4W031"/>
    <dbReference type="STRING" id="1333523.L593_09455"/>
    <dbReference type="EnsemblBacteria" id="AGN01836">
        <property type="protein sequence ID" value="AGN01836"/>
        <property type="gene ID" value="L593_09455"/>
    </dbReference>
    <dbReference type="GeneID" id="16182605"/>
    <dbReference type="KEGG" id="sali:L593_09455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1946"/>
    <dbReference type="eggNOG" id="arCOG04147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_2"/>
    <dbReference type="OrthoDB" id="74803at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="94"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22513" checksum="06E2130F59FE3DC6" modified="2013-07-24" version="1">MSERSNPELPPLPYDYDALEPSISEQVLHWHHDTHHQGYVNGLDAAEETLADARESGDYSATAGALGDVTHNGSGHYLHTLFWENMDPNGGGEPDGDLRERIEADFGSYEGWKGEFEAAASAAGGWALLVYDPVAKQLRTVAVDKHDQGALWGAHPILALDVWEHSYYYDYGPDRGSFVDAFFEVVDWNAVADEYATVVEHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W091</accession>
    <name>R4W091_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Bacterio-opsin activator HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14980"/>
    <dbReference type="EnsemblBacteria" id="AGN02930">
        <property type="protein sequence ID" value="AGN02930"/>
        <property type="gene ID" value="L593_14980"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14980"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_101251_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="23888" checksum="521009A62A2B9957" modified="2013-07-24" version="1">MVTAQIRVEIPPGTWMEELSTRYPNVRFRLLAGVEVDGGEAVELGEVNGELAVEAAAAVGDHVAIGEYETLYASDERVLSRYRTGDLTLYDFLRSISVPPEFPLVVEDGWLECSITASRDRIDELDRTLTAAPVSYELRSLVAEPDSERLLTDRQRELLRAAFENGYYDVPREQTLTDLAATLDVDPSTASGVLRRAERQVVAWFLSSEVHTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0R0</accession>
    <name>R4W0R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447035.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10980"/>
    <dbReference type="EnsemblBacteria" id="AGN02141">
        <property type="protein sequence ID" value="AGN02141"/>
        <property type="gene ID" value="L593_10980"/>
    </dbReference>
    <dbReference type="GeneID" id="16182005"/>
    <dbReference type="KEGG" id="sali:L593_10980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2264"/>
    <dbReference type="eggNOG" id="arCOG02984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_2_2"/>
    <dbReference type="OrthoDB" id="122478at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
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        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="7073" checksum="871317C4376FE8C7" modified="2013-07-24" version="1">MASGTVDFFNDTGGYGFIETEDADEDVFFHMEDVGGPDLEEGQEIEFEIEQAPKGPRATNVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W104</accession>
    <name>R4W104_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="9" type="ORF">L593_11380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447115.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11380"/>
    <dbReference type="EnsemblBacteria" id="AGN02221">
        <property type="protein sequence ID" value="AGN02221"/>
        <property type="gene ID" value="L593_11380"/>
    </dbReference>
    <dbReference type="GeneID" id="16181060"/>
    <dbReference type="KEGG" id="sali:L593_11380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2347"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_1_2"/>
    <dbReference type="OrthoDB" id="7487at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="455"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="605" mass="64460" checksum="84E07DA6C970F14D" modified="2013-07-24" version="1">MCGITARTGRDDAVDDLLDGLQNLEYRGYDSAGIALQNGHGIEVFKQAGETSDLDADVRRRTPSGKIGIGHTRWSTHGPPTDENAHPHTCCTGDVAVVHNGIIENHEELRTELVAAGHTFSSDTDTEVVPHLIEERLAAGDGPEAAFRAAIDRLRGSYAIVAMVAGRDAVYATRSGSPLVLGIADDGYFLASDVPAFLEHTDRVVYLEDGDVATVTASTHTVTDVDGSMVVRPPESVDWNAEDAEKRGYDHYMLKEIDEQPGAIERAIEGRIDAECGAVELEAFPPGSFSDVERVQLVACGTSYHAAAYAQRLLAHRGIPATAHRAGEYAETAATLEPGTLVIGVSQSGETADTLQSLRRIADADVRTLAVTNVVGSTIARETDDALFIRAGPEIGVAATKTFSSQVATLLLLAERLAADVEGAGSDDTEAVLAALQALPDQLRTVVDSSDARQIARRADGRTSHFFIGRDVAHPVALEGALKFKEITYEHAEGFAAAQLKHGPLALVTPDTAVVAVFTGRHDEKTLANVREVQARDAPVVAIASEETHSVVETADELLPIPDTEPELAGLLANVQLQLLSYHVAALLDRPIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W108</accession>
    <name>R4W108_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447120.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02226">
        <property type="protein sequence ID" value="AGN02226"/>
        <property type="gene ID" value="L593_11405"/>
    </dbReference>
    <dbReference type="GeneID" id="16182464"/>
    <dbReference type="KEGG" id="sali:L593_11405"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_3_0_2"/>
    <dbReference type="OrthoDB" id="122935at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="117" mass="13321" checksum="B45A413D58530430" modified="2013-07-24" version="1">MNRTDSEASTDALLRAIADSQRRYVLRELADASASEVTVDALAEVLLDGPTSRSSDRRSRREIAIQLRHVHLPRLEDVGLCRYHEDRDVVEYCPDEFVESLLDLLERRASPEPVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W118</accession>
    <name>R4W118_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447135.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11490"/>
    <dbReference type="EnsemblBacteria" id="AGN02241">
        <property type="protein sequence ID" value="AGN02241"/>
        <property type="gene ID" value="L593_11490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182296"/>
    <dbReference type="KEGG" id="sali:L593_11490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2369"/>
    <dbReference type="eggNOG" id="arCOG05861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602201_0_0_2"/>
    <dbReference type="OrthoDB" id="102661at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_peptide_camelysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="454" mass="47847" checksum="AAB6B09AA97F24E3" modified="2013-07-24" version="1">MTDKETVNLTRRRVLGGLGAIGVASAGAAVGTSAYFTDEESFEDNVITAGSLDLLVDYYSYWNQGRAGTGLVSGTADGNAVTAELDDVKPGDSGLLAFCPRIETNPAYLWLCGQMTANFENGYTEPEPRDNNGQGELAESIQLTVKYCEIEENNDGGFGPDSVSDCNAVWSGTLAEFLARIRTGVPLDGHGRVQDGENGGFFEPGNQECFSGTGSEWESPCVCIDWEIPTSVGNEIQTDTLEFDLEFYAQQCRHNDGTNNPCLPQGTVGTGDFSEISYNKAFSMQALSRAGSGRGEIQIHGDSGGVENTTLWGSNPGDTFPANTDVDFIATVDPVAETASLTVNGETVTDNDVTDGTANGASTGEPEWPGGVPNEVNVALTASSGDANVTTVVKEVDLNGASVNPDNIDATDGLTFLAIENVPATNTVTVEGTLRFEGSTSDFDGQDFVGIDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1M0</accession>
    <name>R4W1M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447415.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12910"/>
    <dbReference type="EnsemblBacteria" id="AGN02521">
        <property type="protein sequence ID" value="AGN02521"/>
        <property type="gene ID" value="L593_12910"/>
    </dbReference>
    <dbReference type="GeneID" id="16180243"/>
    <dbReference type="KEGG" id="sali:L593_12910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2647"/>
    <dbReference type="eggNOG" id="arCOG02865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104065_1_0_2"/>
    <dbReference type="OrthoDB" id="82461at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21656" checksum="A210D99F94646083" modified="2013-07-24" version="1">MADTASPSLDDGPSWLKDNVAAVTAVLTVVGYALVIATFEGMIPFYPNIGKSGVNLLGHAIAVVNLAATVCLIAGWRYVKQGKIEAHAKSMTAAFALILLFLVLYLPKVGGGGEKRLVESVPDPIALGYFVMLAIHIILSAIAMPVVLYAFLLGISHTPAELRDSLHPRIGRIAAASWILSLVLGVVTYLILNHVYSYEFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1R0</accession>
    <name>R4W1R0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">L593_13185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447470.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51463">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="64"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="431" mass="45121" checksum="617318DB8730D3AE" modified="2013-07-24" version="1">MDVDIAGALSEHASPGVARASIDRLDDRVAAAHERIEAGRADGEHGYAALNLPERTDPAEITTAVDRIARPIDTVLVAGIGGSALGAATLANAVETDAEVVTLDNVDPAPTHRLLDAKTLDRTALVAVSRSGTTVETLANVQVVRGAFEDAGVDWTDRTLVVTGDTGPLRRLADEAALPALAVPEGVPGRFGALSAVGLAPIALAGGDVESILAGGAAGDAALAGSLYECPPYAYGAVSYALAQRGATVSAMMPYAEALESFGEWYAQLWAESLGKDGVGQVPQRALGATDQHSQLQCYRDGPRSTVVTTVRPRERPDCPVPEPDDPDLAHLQGTTLGEIVDLECAATTASLTATDRPVVRVEIDRVDAHGIGELLYCFEAACVLAGELFEVDAFDQPAVEWGKDATRALLRGEETESTRAIEDRESLWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2D8</accession>
    <name>R4W2D8_9EURY</name>
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        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_14510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AGN02841"/>
        <property type="gene ID" value="L593_14510"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_14510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2967"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="253" mass="27627" checksum="5766F514E6228541" modified="2013-07-24" version="1">MWSVGGRTLFKREVQRFVRRPKNTFMPPAITNVLYFAVFGVVLGGRIDEIAGFPYIQFILPGLIVLGAISNAFENASFSIFHGRWNEYIDEPLTSPLSYTEIVAAYVGASALRGLLVGIIIAGVGRLFAPISVRHGAVLVVTMVVICVLFAGLGMIGGLFARDFDDLTVMNQFILRPLVFFGAVFYSLDVLPDLWRTVSLLNPMVYMVDTIRYGLLGYSDLTPAVSVVVLVGVTSAVLTIDVLLVRRGVGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2K3</accession>
    <name>R4W2K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00260"/>
    <dbReference type="EnsemblBacteria" id="AGN00007">
        <property type="protein sequence ID" value="AGN00007"/>
        <property type="gene ID" value="L593_00260"/>
    </dbReference>
    <dbReference type="GeneID" id="16181256"/>
    <dbReference type="KEGG" id="sali:L593_00260"/>
    <dbReference type="eggNOG" id="arCOG02395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357962_0_0_2"/>
    <dbReference type="OrthoDB" id="71032at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="22069" checksum="DFCB89F572B7B21B" modified="2013-07-24" version="1">MELPEELIGIEEELDIDETAEPDVALGETEAEGQRQEEEEEREQFVRFSLGDQSYALHVNAVRRLVDVGERTRVPRTSEAIDGITDLRGEITAVIDPRVLFGLPESERSVDVQELIVFATGSNQGNAGIRVDVVDGVEAIPVSHVVLEPEDVSTDAEMVSQRLEEPLVAGLIREDDGEGGFEYTPVVDVDAMLDVARKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W346</accession>
    <name>R4W346_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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    </dbReference>
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            <end position="230"/>
        </location>
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        <location>
            <begin position="298"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="47115" checksum="0D7C0D8FF1FB4B6A" modified="2013-07-24" version="1">MRNSTTVLLALVALVALAPIVGVVGAADVGVGTQDSSANDGAATTNASTGAQLATVIQVTDEEVRHDVEVGSLEAELDAENDSERAAAIANLSATLQDRAGQIAADYEAATMAYDEGELSAAEYGQRLAVLHARADAIQNGFDRVSVAAAQTSPDALEAAGYNAAEVAEARQQLRSVSGSGTAALLAQFTGQSDGEFSVETENGLEVEVESEDGEYSRGFEGEEPEHGTFEVNRSEAQATAEAALSSPDDNGTWTLDEAETEDDGYYEFEFEYQGPSSSGEAEVSVDARENAVFSLEEEIEREAEDDGDDEEDDESEGELTITVVDGDPATDDTVTIRVTDAEGNPVAGADVEVDDGAGGTTDENGTVTVQVGEDGFDVEVEHGDSEGELEMEFEGDDSDDSSDDSGSDEDDGDDSDDSSDDSDSDEDDGDDSDDSSDDSDSDEDDGDDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R4W381</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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        <property type="protein sequence ID" value="AGN00367"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2550430_0_0_2"/>
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            <dbReference type="EMBL" id="AGN00367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="82" mass="8817" checksum="BECAB38927D89B98" modified="2013-07-24" version="1">MRVEFVPASSASRTASLGVPIDSVEECSVPTSSRRTTTFLCNAGSVSGSFARSGDWADRRPARYESLAVRALYRLGRGFVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3E8</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
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    </feature>
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        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="14849" checksum="C8AF82C2651DEEB4" modified="2013-07-24" version="1">MNVDAYRIDWLTRRRYLAYVLVTSLVGGGIVGYLLGGEHTAAALAAAGVVAIAIVVPKLLARRTLFDERDRRMDERAAWYTMVIVLALALPSLVAPIVLEQLGVVPLQGWLLGIGIVLMGIVYLYLAIVLALNYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3G2</accession>
    <name>R4W3G2_9EURY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AGN00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="43352" checksum="78E7DF3A1A17F671" modified="2013-07-24" version="1">MVGVNASIWAHPWDLVDEGPEAVAERLDDLGIDTVNLATTMHSVQTLNPHNPERKTFFADASAYFQPDESRYGELTPDVNETMGEADWVGEITDAFAGSPVALRSWTVPFHSSKQGRNHPDATMRSPFGDSLVWGLCPSNPDVQEYGRALAADVADARDFEAVEMELADYQYGTGYGWHHQEFFTELGPLGEFLFGLCFCEHCRANATDAGVDVDAARESAQDALDARFDGDLAADTDVGGWLAEHPAVRDYAHVRRETLSELLEDFADEIAPADFTYYLKMGGLGDDRMGIEHSWKHGLDLDALSGIVDGVTVLAYHEDPTVVRDDVRATRTMLDVPVTAGILAGHPILDSKARLRSQIETAVDAGADRLSFYGYGVLPERNLEWIGDVLDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Y7</accession>
    <name>R4W3Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">L593_04255</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00802">
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        <property type="gene ID" value="L593_04255"/>
    </dbReference>
    <dbReference type="GeneID" id="16180886"/>
    <dbReference type="KEGG" id="sali:L593_04255"/>
    <dbReference type="eggNOG" id="arCOG02646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="81806at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="BetI_C"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="24650" checksum="BB3F1979570D6834" modified="2013-07-24" version="1">MIGRMSDPVALFADPETSEEEIYRATWEALQAHGLTDLSIQRIADQTDLGKSTIYHHFEGKDDLLTSFVSEFMREHVDALVLQLPEDDMLTLFDRSLDLFILGEGPDGTTLDSLVGDKINDVYLQLRAHAATDPAYQSAIAEADAVGRERMVAMIESGQAEGLIRDTVDPERAAATIYAFVETALLVQSTSDDTDWLRHVRASADDYMADIVADGVSWPPDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4D4</accession>
    <name>R4W4D4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ORF">L593_05565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445956.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05565"/>
    <dbReference type="EnsemblBacteria" id="AGN01062">
        <property type="protein sequence ID" value="AGN01062"/>
        <property type="gene ID" value="L593_05565"/>
    </dbReference>
    <dbReference type="GeneID" id="16181427"/>
    <dbReference type="KEGG" id="sali:L593_05565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1137"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OrthoDB" id="70525at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="22812" checksum="17B97A4A74FAF8EB" modified="2013-07-24" version="1">MLRASFSGSSYVGVFARAAAGHLLVRPDVDVSLQQSIADELGLEPLPTTVGGSGTVGSLAVGNDNGILVSSRALDRELDRIRDAVSVPVAELPGRINAAGNVVLANDTGAYVHRELGDEAVEVIEETLGVPVDRGDVASVRTVGTAAVANDRGVLCHPKATDEQLDHLAEHLDVHADIGTINYGAPLVGSGLIASEDGYVVGEDTTGPELGRIEDALGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W537</accession>
    <name>R4W537_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446391.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07760"/>
    <dbReference type="EnsemblBacteria" id="AGN01497">
        <property type="protein sequence ID" value="AGN01497"/>
        <property type="gene ID" value="L593_07760"/>
    </dbReference>
    <dbReference type="GeneID" id="16182822"/>
    <dbReference type="KEGG" id="sali:L593_07760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1590"/>
    <dbReference type="eggNOG" id="arCOG02609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_8_2_2"/>
    <dbReference type="OrthoDB" id="124641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11341" checksum="B1B57C43FE81C071" modified="2013-07-24" version="1">MPAESAEEQPAITLYRLQACPYCERVVRRLHELDLDFQSRFVEPMHGDRDVVKRVSGVRTVPVIVDRTTGVTMAESANIVDYLDGTYGAEADDADAAPATGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W580</accession>
    <name>R4W580_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leuS</name>
        <name evidence="15" type="ORF">L593_08135</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446466.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08135"/>
    <dbReference type="EnsemblBacteria" id="AGN01572">
        <property type="protein sequence ID" value="AGN01572"/>
        <property type="gene ID" value="L593_08135"/>
    </dbReference>
    <dbReference type="GeneID" id="16180159"/>
    <dbReference type="KEGG" id="sali:L593_08135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1667"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_2"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="243"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="440"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="679"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN01572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="912" mass="102491" checksum="768B4625D67F4BED" modified="2013-07-24" version="1">MTTGEPEPQERRFDHREIEPAWQAAWDDADVFRIEDDETDPEYVLAMFPYTSGNLHMGHVRNYTITDAYARFERMRGESVLHPMGWDSFGLPAENAAEERDTNPRDWTLSCIDSMKEQLNRMGFGYDWEREVTTCDPDYYRWNQWFFQRFREEGLVDRRAEEINWCPSCETVLADEQVETPDGDAGSGEGGVTGEGICWRCDSVVETRELDQWVFTITDYADELLEALDDLDGWPNNVREMQRNWIGRQEGDSVEFELTTGDSVEIFTTRLDTIHGATFFAMSPGHEVAQRMAENPEEYPEVAEYVERAEALGDDEELPETSGAFTGEFATNPATGEEIPVYVADYVLEDVGTGALYAVPAHDDRDHAFAEEHEIPIQQVVEPAADADADPESIDVQEAAYTPDGILINSGEYDGLESAAAREEFVDVFDGEHRVEFRLRDWLISRQRYWGTPIPMIDCEDCGYVPVPEDDLPVELPEFVHTTGNPLDAAEDWKHVDCPECGGDAVRETDTMDTFVDSSWYFLRYCSPDLDDAPFDHDRASDWMPVDQYVGGIEHAVMHLLYARFFTKMLDDMDLLSGTREPFTNLTNQGMVLGEDGNKMSKSRGNGVSPQRMIDEYGADTARLFTMEAAQPQKEFAWSPEGVESAHQYLQGVYDLATRVEEGAFEDSADGDGEGVAAYVERETDATVATATEEYEAFRFNHALQSTRELVSLLRRYADRDDATQEPIERGIDTVARILGPVAPHVTEEIWSLLDRDGLLAEASWPDAEPPADYEIEARLVENTREDVRDIVDVADIEDPQRIEVAVAPQWKHDAIEIATNADGDVVGAVMSDEDLQRHGNEAADFAKDLAGNAEAIDEQLSPEGELAALERAAWLLRDEFGADVEILSAADADDDLASKAEPGRPAIHIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W589</accession>
    <name>R4W589_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446481.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08210"/>
    <dbReference type="EnsemblBacteria" id="AGN01587">
        <property type="protein sequence ID" value="AGN01587"/>
        <property type="gene ID" value="L593_08210"/>
    </dbReference>
    <dbReference type="GeneID" id="16181294"/>
    <dbReference type="KEGG" id="sali:L593_08210"/>
    <dbReference type="eggNOG" id="arCOG01264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_2"/>
    <dbReference type="OrthoDB" id="36699at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="321" mass="34214" checksum="8775E54063EB54E1" modified="2013-07-24" version="1">MTVQPTVVSSTSTTDLDDRTVVLTGGTSGIGRRAALDLADRGAMVAAVGRDEERGREVETAAADAAGDVAFHRADLAEQAAVRELAEELFASYEEIHALANNAGLARGDRIESPDGVELTFAVNHLAPYLLTHELLPRLRESAQSIDGPARVVTTSSGLQYRGELDFDDLQFESGYDGLDAYSRSKLANAVFTVELAERLDAAGMGPDDGGAGSAADGVVANCFSPGFIRGTRIWLGSAWRSRLLTWLVAWVPGVGTDLQTGADRMVDLLAAPEYGERNGVYVDQGEEQSPDYDAQDPAVREQLWDVSADLVGVDPDWPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5C1</accession>
    <name>R4W5C1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446531.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08460"/>
    <dbReference type="EnsemblBacteria" id="AGN01637">
        <property type="protein sequence ID" value="AGN01637"/>
        <property type="gene ID" value="L593_08460"/>
    </dbReference>
    <dbReference type="GeneID" id="16182375"/>
    <dbReference type="KEGG" id="sali:L593_08460"/>
    <dbReference type="eggNOG" id="arCOG01402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095289_0_0_2"/>
    <dbReference type="OrthoDB" id="118913at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22906" checksum="92F76B7F9ABD1CDA" modified="2013-07-24" version="1">MIDATEEATVRTRVLNGVAVPSTDLEEGVDTYPTHEETVVAALRRHVRRGDRVVVVGGGWGTSTVVAARMTHFEGEVTTFEPASEMLEIVRRTVEVNRVADVVTLEHAAIGSVSDSSERIFGRADGDVRPPSAIPDCDVLDVDCEGAELDVLRGLECRPRLLTVEAHPHLGGSHDEIEAEFDRLGYEIAHREPIASDDDIVNYVARRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5G5</accession>
    <name>R4W5G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arsenite transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446591.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08760"/>
    <dbReference type="EnsemblBacteria" id="AGN01697">
        <property type="protein sequence ID" value="AGN01697"/>
        <property type="gene ID" value="L593_08760"/>
    </dbReference>
    <dbReference type="GeneID" id="16180567"/>
    <dbReference type="KEGG" id="sali:L593_08760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1795"/>
    <dbReference type="eggNOG" id="arCOG00237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_1_2"/>
    <dbReference type="OrthoDB" id="65032at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="234"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="660" mass="69649" checksum="6FBBB4F012D74DEE" modified="2013-07-24" version="1">MHVGAWPAFAIVLQAAAEPPALTTGMLVVFGIVLAALVLFVWEPVPIDVTAIAVLVALVALGDWTELTIEEGLSGFSSPATIAVLAMFILSEGIRRTGLVSVIGREIADRYGNSPIKQLGAVLGLAGGTAGFINNTPVVAVMIPMVDELADRTGTSPSKLLMPVSFAAMMGGTLTLIGTSTNLLASDVYAQLGPQYDAFSMFEFTALGVLVLAVGSVYLFLVAPRLIPERVPAREPLTEEFEMTEYLTEVVVRGDSTFVGDTVEGCLAELDVDADIVQLVRTDAAFSEPLARKTIQADDVLVLRTDRESLVTIIEHEGLELAPDARKGDAAPPTVGADAASVDDDALEELVEEALEVEDVTDELLTADDEAVEAVDDQRLVEVVIAPDSRLVGETLESLHFRQRYDASVLAIRRGGEIIHARMDERSLRAGDTLLVQATEETVSRLAIDREFIVAGEFDLPQYREEKLPIALGIVAAVVAIAGLGIASIALSALAGVVAMVVTRCLRPGEVYDAVDWNVVVLLAGLLPLGLAMEQTGAAAFLAGHVVQSAGGLTPILLLGVFYLLTAVLTNVVSNNASVVLLIPVAVDVAVATGADPFAFAIAVTFAASTAFMTPMGYQTNLMVYGPGGYRFMDFVRVGAPLQLLLAVVTVLGIWGIWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5N2</accession>
    <name>R4W5N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446736.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09485"/>
    <dbReference type="EnsemblBacteria" id="AGN01842">
        <property type="protein sequence ID" value="AGN01842"/>
        <property type="gene ID" value="L593_09485"/>
    </dbReference>
    <dbReference type="GeneID" id="16182727"/>
    <dbReference type="KEGG" id="sali:L593_09485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1953"/>
    <dbReference type="eggNOG" id="arCOG01265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_2"/>
    <dbReference type="OrthoDB" id="60440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="25980" checksum="4E427313AA5C811B" modified="2013-07-24" version="1">MPRTAIVTGASSGIGEATAHELADEGIDIALAARRADRLESIAADLESEYGVDAVAVPTDVREETAVEALVEATVERFGGLDVLVNNAGLARGHLVTELDTDDYRTMTETNEDGVFFATRAALPHLTESEGHLVFVGSFAGQYPRPFNPVYAATKWWVRGFAHSVGAQVGDEGVAVSVVNPSEVRTEFGGDDGDSFAETFEPGEVTEPIEIAEAIRFAATRERSGVSEIDLYRRDKFADTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V9</accession>
    <name>R4W5V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01967">
        <property type="protein sequence ID" value="AGN01967"/>
        <property type="gene ID" value="L593_10110"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10110"/>
    <dbReference type="HOGENOM" id="CLU_1943944_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14061" checksum="258FB5BF966D3204" modified="2013-07-24" version="1">MGFDADGAVDHLLEAAGDDVLVVAEYTPGDYRLLYVSDDLEAMYGSGEAVAEAADSIHEYIDLDFRERELFLDLYPTIDDVDGLITVATDRSVVRVVTPRDEGLYFSVPNDLDVTALLEAVVGIVEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W614</accession>
    <name>R4W614_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445002.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00765"/>
    <dbReference type="EnsemblBacteria" id="AGN00108">
        <property type="protein sequence ID" value="AGN00108"/>
        <property type="gene ID" value="L593_00765"/>
    </dbReference>
    <dbReference type="GeneID" id="16182090"/>
    <dbReference type="KEGG" id="sali:L593_00765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.157"/>
    <dbReference type="eggNOG" id="ENOG502N5QJ">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023504_3_0_2"/>
    <dbReference type="OrthoDB" id="132449at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="DUF4038"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032260">
        <property type="entry name" value="DUF5060"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="DUF4038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16586">
        <property type="entry name" value="DUF5060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5060" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4038" evidence="1">
        <location>
            <begin position="100"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="507" mass="55412" checksum="1AD849D24FF78A60" modified="2013-07-24" version="1">MASTWHPVELDFEATDPPANPYGEELLDLRLEHESGATHTVPGFWDGGDVFRARFAPPELGTWTWETITDDPGLEATGSFDATPGDVGAPIHDHGYLRAGERALRHADGTPFFWLADTAWTASTRATTDEWEKYLDHRVEQGYNVVQVNALRQHDGSRPHDRIPFEDWDLSRPNHDYFQHLDDLVAMAHGRGVVPALVALWFDYAGANPDWGIPEERRNEHSPEQARTLGRYLGARYGAYGAAWLVSGDSHVDESSLPIYRAAGEVLGEACQHPLRTAHMPGGQNTPTTLNDEAWLDFHMYQSGHTHDLTVPKRQARVNRGLHPARPVLNGEPAYADMRAYADETVLERETVRAAGWLSVLAGANAGVTYGAHGVWPWHRASDTFESAELWGEPKPWDEALSLASGDDYARIADVLSARAAESLSPRPDLLADADETEAAAVTPDAVLVYLGEGRAIELQDAPPLDAVSWYDPATGETADAATTNAAGDLEVATPPFGGDAVLLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W620</accession>
    <name>R4W620_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445012.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00815"/>
    <dbReference type="EnsemblBacteria" id="AGN00118">
        <property type="protein sequence ID" value="AGN00118"/>
        <property type="gene ID" value="L593_00815"/>
    </dbReference>
    <dbReference type="GeneID" id="16182140"/>
    <dbReference type="KEGG" id="sali:L593_00815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.167"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="197"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="31058" checksum="2A78BDE69D1F98A0" modified="2013-07-24" version="1">MEYVQAGDAEIPELGLGTWQNTGQSCAETVETALELGYRHVDTAQMYGNEAQVGEGIERSSVDRDDVFLTTKLDRGNLEADDARESFEESLEKLGTDYVDLLLIHWPHPRVPFEETLGVMDELHDEGTVRHIGVSNFTPAQLEEAMGITRAPIVTDQVLYNPYKDQSDLHAFSLESDVALTAYSPLGRGDAISDSMLAAIGERYDKSAAQVALRWLVQQENVVAIPKATSREHLEANLAIYDFELTRDEMERIATLDGGIKRRIWNRFPGLMRRIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W676</accession>
    <name>R4W676_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447056.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11085"/>
    <dbReference type="EnsemblBacteria" id="AGN02162">
        <property type="protein sequence ID" value="AGN02162"/>
        <property type="gene ID" value="L593_11085"/>
    </dbReference>
    <dbReference type="GeneID" id="16182335"/>
    <dbReference type="KEGG" id="sali:L593_11085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2287"/>
    <dbReference type="eggNOG" id="arCOG01900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_1_2_2"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="27481" checksum="3EEDABB0B0F0515E" modified="2013-07-24" version="1">MNLSVVPWGFFPEASTAEQIERVAAAGADAIEILDLGELSPEEARDHAADHGIDVAVLQASGETVGIDNVAPAIVDPGSVEQSIAELESSIEAAAAADARNCLAVVGQRQPTVPRHEQRSAIVETFRSVAPAAEDAGVTVVPEVLNAVDDHPGYFLTDPGEAYSIAEAVDSPNVGFLLDVYHQQREHGNVVPTFESTIDHVEHVHFADAPGRNEPGTGELAMERILTALDELGYDGYVGAEFSATGDPDETLRDVVELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A8</accession>
    <name>R4W6A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445152.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00258">
        <property type="protein sequence ID" value="AGN00258"/>
        <property type="gene ID" value="L593_01525"/>
    </dbReference>
    <dbReference type="GeneID" id="16179850"/>
    <dbReference type="KEGG" id="sali:L593_01525"/>
    <dbReference type="HOGENOM" id="CLU_2748361_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7663" checksum="62B5D64A4358232A" modified="2013-07-24" version="1">MVFLRAGVVIAIFGVLMVAFPEQMLAFQRWRYPEEVLETNPTRIGYVRYGGVAFVAIGAAFVAGAQLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B2</accession>
    <name>R4W6B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tfx</name>
        <name evidence="3" type="ORF">L593_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01575"/>
    <dbReference type="EnsemblBacteria" id="AGN00268">
        <property type="protein sequence ID" value="AGN00268"/>
        <property type="gene ID" value="L593_01575"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.320"/>
    <dbReference type="eggNOG" id="arCOG04554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125807_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004645">
        <property type="entry name" value="Tfx_DNA-bd_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00721">
        <property type="entry name" value="tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="17554" checksum="1FB297EC3A30A5BF" modified="2013-07-24" version="1">MTDSDRGDGSTVASVGAVADSEAADILADAGFDAEASVLTPRQAEVLALRERGLAQNEIAERLGTSRANVSSVESSARRNVEKARATVAVAEALQAPVRLQFEPGTDVYEIPDRVYAACDDAGVKVDAATPELISIVTEAAGGAFEGRRLVDPVTIAVTAEGEIRVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E3</accession>
    <name>R4W6E3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447146.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11545"/>
    <dbReference type="EnsemblBacteria" id="AGN02252">
        <property type="protein sequence ID" value="AGN02252"/>
        <property type="gene ID" value="L593_11545"/>
    </dbReference>
    <dbReference type="GeneID" id="16182752"/>
    <dbReference type="KEGG" id="sali:L593_11545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2380"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_2"/>
    <dbReference type="OrthoDB" id="12911at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="294"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="398" mass="41866" checksum="3FE105D1C1733C49" modified="2013-07-24" version="1">MGGAPDDEYSKPPAEETLRADDPAAVELAVRQGDPLSGANGFAGLVDLGSPGSDGDRALVRDVLGREPLYIEADAPTDGIPADDAWAFDPTALDDPVLFPAGAIQDEAGRRDRLRLPTNSGVGDVGGSAAAVPGSAVDELRDAIDAALGALDDATPVAFSGGVDSGLVATGTDGPLFVAGFPESHDLEAARDAAAAMDRELREVRLTHDAIERAVHAVAEATGRTNPMDVSIAIPLYLVAERVAADGHETLAVGQGADELFGGYAKVAKAPEDDRVEADSVAGARDELLGTLPEQLPRDVLAIRAAGVEPIAPLLDDRVVRAALALPEALLVRDEERKVALRRVATDRLPESVAIRDKKALQYGSLVSRELDRLARQHGFKRRMDDHVGQYVRDLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N9</accession>
    <name>R4W6N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447331.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02437">
        <property type="protein sequence ID" value="AGN02437"/>
        <property type="gene ID" value="L593_12490"/>
    </dbReference>
    <dbReference type="GeneID" id="16179993"/>
    <dbReference type="KEGG" id="sali:L593_12490"/>
    <dbReference type="HOGENOM" id="CLU_171538_0_0_2"/>
    <dbReference type="OrthoDB" id="116231at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="B0C91B84FEC57415" modified="2013-07-24" version="1">MRIAIELHIVSKASDYVMNVSGLTQVTSGEEGSREYQAALLGEIRKRDRAIVQMLRDLGVLNDSESKKAEFLDEWRSWVEDGDRGIPQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S2</accession>
    <name>R4W6S2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ORF">L593_02960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445437.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02960"/>
    <dbReference type="EnsemblBacteria" id="AGN00543">
        <property type="protein sequence ID" value="AGN00543"/>
        <property type="gene ID" value="L593_02960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180393"/>
    <dbReference type="KEGG" id="sali:L593_02960"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.599"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OrthoDB" id="115947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="11760" checksum="5541C42914939BEB" modified="2013-07-24" version="1">MKQAIVARADLNMGEGKLAAQVAHASLSAVEDADGTAKREWQGSGQKKIVLQANGEDQLFELADRAERAGLPHAIVRDAGHTQLEPGTVTALAIGPASERAVDEITGDLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6V4</accession>
    <name>R4W6V4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="4">FBPase class 1</shortName>
            <ecNumber evidence="4">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fbp</name>
        <name evidence="7" type="ORF">L593_13015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13015"/>
    <dbReference type="EnsemblBacteria" id="AGN02542">
        <property type="protein sequence ID" value="AGN02542"/>
        <property type="gene ID" value="L593_13015"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13015"/>
    <dbReference type="eggNOG" id="arCOG04603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="6">
        <location>
            <begin position="174"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="31009" checksum="06D1B341EC5E5399" modified="2013-07-24" version="1">MDDGDPTVSTVHADATVDEILEELLATAPELRSLQAARRGGETDEENPTGDELIAADAAADEHLVDALAAIDGVGTVASEERAELVDAGDGLSVTVDPLDGSSNLAANAPTGTILGVYDADLPAPGRSILASAMVVYGPVTTAYVAIEGEGVTEYELPPGDDAEPTVAEADVTIPNDPTIYGVGGGDDDWPEPVADVVDALREQHKLRYSGALVADVSQVLTSGGLFAYPQLESSPTGKLRHQFEVGPIAFLVESAGGASTDGNGSLLDRPAQELHGRSPIYVGSEAAIERVEAILGDRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W750</accession>
    <name>R4W750_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445627.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03910"/>
    <dbReference type="EnsemblBacteria" id="AGN00733">
        <property type="protein sequence ID" value="AGN00733"/>
        <property type="gene ID" value="L593_03910"/>
    </dbReference>
    <dbReference type="GeneID" id="16180600"/>
    <dbReference type="KEGG" id="sali:L593_03910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.795"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_2_2"/>
    <dbReference type="OrthoDB" id="40930at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="325" mass="34091" checksum="152F95E38CAD2409" modified="2013-07-24" version="1">MTETPPLVAGETLIDFVPETAEPLAAVERFDRRAGGAPANVAVGLARLGRTPQFWTRVGADPFGDFLADRLAEEGIPERFVERDDEAATTLAFVSGADEGPRFSFYRDGTADTRLQDGTVPDEALDSSPLVHAGGVALADEPARSATLDLLDRATAADCTVSFDPNVRPELWANDAELATICGWAIEETDVLIATPDELETLGYEGDDPETLASAAAEDGPHTVVLTMGEVGALALATGDAPWGPATERHEGYAIDAVDDTGAGDAFSAGLIDALDRVTRRDDPSTASLGDALAFANAVAAMSTTERGAMEALPTKRNVEVFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W768</accession>
    <name>R4W768_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447596.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13815"/>
    <dbReference type="EnsemblBacteria" id="AGN02702">
        <property type="protein sequence ID" value="AGN02702"/>
        <property type="gene ID" value="L593_13815"/>
    </dbReference>
    <dbReference type="GeneID" id="16180856"/>
    <dbReference type="KEGG" id="sali:L593_13815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2827"/>
    <dbReference type="eggNOG" id="arCOG04775">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514566_0_0_2"/>
    <dbReference type="OrthoDB" id="74033at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043853">
        <property type="entry name" value="DUF5815"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19132">
        <property type="entry name" value="DUF5815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="19903" checksum="BB7A1F2E84635EB9" modified="2013-07-24" version="1">MTEPRVPGTDPGGAIELPCGETIGPQDLDLGLREFHCACGEDHAVVMDVHPPARFVPEFLVEVLQSVVDVEDDFETFGTPHVMGAVIEEFPEQVATHDASSDGEVGYAMVWITEFDDRRLHEIVVELLIELMDHAISHAEDQDHAAVFDQHLEDFDVEAFVDQYRAERDFESERDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W778</accession>
    <name>R4W778_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KaiA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445702.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04285"/>
    <dbReference type="EnsemblBacteria" id="AGN00808">
        <property type="protein sequence ID" value="AGN00808"/>
        <property type="gene ID" value="L593_04285"/>
    </dbReference>
    <dbReference type="GeneID" id="16180890"/>
    <dbReference type="KEGG" id="sali:L593_04285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.872"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_2_2"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="26151" checksum="A3D204E7F7BAF72E" modified="2013-07-24" version="1">MRVATGVPGFDTLVEGGLLTNRLYIVSGPPGSGKSTFASQFVTKGAIDGQTSLFLSLHETSEELVQDMSRYEFGFDKAVSSGRVKFLNVFDSEAKRLLAPSSRSGGDFPDNVENMTNQIVSFVDSKDIDRLVIDSAMLLEYYFSDDLDDFIKFLTALKRADATTIVISEMTDPTSYSDEHYLAHGVFFMHNYLEEGGMQRGVQIIKMRGTDIDSNIHAARFSDRGLRVDPDQILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W780</accession>
    <name>R4W780_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rps24e</name>
        <name evidence="5" type="ORF">L593_13915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447616.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13915"/>
    <dbReference type="EnsemblBacteria" id="AGN02722">
        <property type="protein sequence ID" value="AGN02722"/>
        <property type="gene ID" value="L593_13915"/>
    </dbReference>
    <dbReference type="GeneID" id="16180948"/>
    <dbReference type="KEGG" id="sali:L593_13915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2847"/>
    <dbReference type="eggNOG" id="arCOG04182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_3_1_2"/>
    <dbReference type="OrthoDB" id="124805at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11980" checksum="77147B463374764C" modified="2013-07-24" version="1">MDVDIIEEDENPMLHRTDVRFRVVHEETTPERLSVRDSLAAMLNKDAEEVVIRKLDTKFGMRETIGTAKVYDDAEYATDIEQDHMLERNKIGVEAEADEEAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W781</accession>
    <name>R4W781_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445707.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04310"/>
    <dbReference type="EnsemblBacteria" id="AGN00813">
        <property type="protein sequence ID" value="AGN00813"/>
        <property type="gene ID" value="L593_04310"/>
    </dbReference>
    <dbReference type="GeneID" id="16181685"/>
    <dbReference type="KEGG" id="sali:L593_04310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.877"/>
    <dbReference type="eggNOG" id="arCOG02021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_2_2"/>
    <dbReference type="OrthoDB" id="25677at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41175" checksum="620B65E575AAC5B4" modified="2013-07-24" version="1">MVDKITPATLAERIDADEQFALIDTRPEDSYEAWHVPDAANVPFDPDEGLSEDQLNQVNALVDGRPVVAICGKGLTSTPFAFALEEHGYDDTSVVTGGMEAWSTVYETVPIETRNDDLVVRQLQRRAKGCLGYVVGSKQAEEAVVVDVTRQTDEFAVAAQDAGLAITRVLDTHVHADHLSGGPALADEIGVPYHLGEAARERGVEYEYDPLSDGEVVELGDVEIEALHTPGHTTEMTNYLVDDELLLTGDTLFLDSVGRTELQFGEADAARGAELLYDSLHETVLDHPGDAKVLPGHLSVANDGRYETGSPGEPHVARLGDLRATLDLLGLDRERFVEQLAENAPEKPPNYERVIAINTGKATLDEGEATELELGPNNCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A3</accession>
    <name>R4W7A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445747.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04510"/>
    <dbReference type="EnsemblBacteria" id="AGN00853">
        <property type="protein sequence ID" value="AGN00853"/>
        <property type="gene ID" value="L593_04510"/>
    </dbReference>
    <dbReference type="GeneID" id="16181150"/>
    <dbReference type="KEGG" id="sali:L593_04510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.919"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OrthoDB" id="56644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="36574" checksum="0B835EC4970A1E91" modified="2013-07-24" version="1">MKAVQFTGTGGTDVIEYAEVERPEPGPGEVLVDVKAGALNHVDVWARRGLPGNDLSYPHTPGCDGAGVVEAVGEAIERFAPGDRVAVWPGVSCGTCEFCRRGEPSMCVEYALLGEHLPGVHAEYAAVPEENLVPVPDGVDWATAGAAPLVFGTAWRMLIERGDVSAGETVLVLGASGGVGHAAVQIADHAGATVFATGSSEAKLDAARDLGAEHAIDYEREDFADRVRELTDRRGVDVVVDHVGAATWQDSLRSLAKGGRVLTCGATTGPNPETSIGRIFWNQLQVIGSTMASPGELDRALELVWNGEFEVEVRETLPMSETARGHELLESREGFGKVVLVPDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A8</accession>
    <name>R4W7A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tryptophanase/L-cysteine desulfhydrase, PLP-dependent</fullName>
            <ecNumber evidence="5">4.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tnaA</name>
        <name evidence="5" type="ORF">L593_14215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.1" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14215"/>
    <dbReference type="EnsemblBacteria" id="AGN02782">
        <property type="protein sequence ID" value="AGN02782"/>
        <property type="gene ID" value="L593_14215"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2909"/>
    <dbReference type="eggNOG" id="arCOG04196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047223_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009034">
        <property type="term" value="F:tryptophanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018176">
        <property type="entry name" value="Tryptophanase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00853">
        <property type="entry name" value="BETA_ELIM_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="455" mass="48172" checksum="0785B9F01846A24F" modified="2013-07-24" version="1">MVDRRSVPDQGERERILAEAGYNLFAVPADAVAVDLLTDSGTGTMSSEQWGALLQGDEAYAGSSSFADLESAVSAVMGFDRIVPAHQGRGAEHVLYGAIVDDGDVVPNNTHFDTTRAHVEAAGGDPVDCPVEGARDPDAEGDFLGNLDVDAARAVAAEHGEDQVPAIVVTVTNNAAAGQPVSIENVRRARTLADEIDARLVIDACRFAENSFFVKEREPGWGDASIQEIARELLGYADALVMSGKKDGLANVGGFVAVADDGTEAADALFDELKQRAILYEGFPTYGGMAGRDMAAMAVGLREAVELPYLEDRIGQVRELADLLEAAGVPIYRPVGGHAVYLDAASALPDVPAHQFPGQTLVCAGYLEGAVRTVELGSFAFPDTDRPELVRLALPRRTYHREHLELVADTFGQVVDRAASLGGLEIVDEPGRASLRHFSARLAPVDGELVAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A9</accession>
    <name>R4W7A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445757.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00863">
        <property type="protein sequence ID" value="AGN00863"/>
        <property type="gene ID" value="L593_04560"/>
    </dbReference>
    <dbReference type="GeneID" id="16181001"/>
    <dbReference type="KEGG" id="sali:L593_04560"/>
    <dbReference type="eggNOG" id="arCOG09242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176744_0_0_2"/>
    <dbReference type="OrthoDB" id="113875at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13252" checksum="791288D7B8DE068B" modified="2013-07-24" version="1">MSTTATPPAPDGLDLSRAEQWVLHHVMVEHVDRAYEANDAPPWWAVSIAGKLETGGDAGPSPGTGVELGDRVTTFEAWRIRQALVEYADRTDVPEDDADLAWRIVERLETDFEAAPRAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D1</accession>
    <name>R4W7D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-forming long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447731.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14490"/>
    <dbReference type="EnsemblBacteria" id="AGN02837">
        <property type="protein sequence ID" value="AGN02837"/>
        <property type="gene ID" value="L593_14490"/>
    </dbReference>
    <dbReference type="GeneID" id="16181609"/>
    <dbReference type="KEGG" id="sali:L593_14490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2963"/>
    <dbReference type="eggNOG" id="arCOG04199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_2"/>
    <dbReference type="OrthoDB" id="6295at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="659" mass="73711" checksum="53A60BD5FEF7968C" modified="2013-07-24" version="1">MDRLETERSVSDRITTMTTLPVMLENTADEYSDRQAQGYKGGIYDRSLAPTAISAPPPDDYETLTYDEMRQVVRRLAAGFRSLGLAPDDRVGIFADTRLEWAQSDFAILAAGGVVTTVYESSSPDQVRYLLDDPGASGVVVENQQLLERVLEVEDDLALEWIVSMDELDDRYDERDDVYELVDVFERCREAFDEATYQSWLDERDPDDLASLVYTSGTTGQPKGVRLSHRNFRANVNQVHRRQGKRSDKHYSVPVIDRTTRTVSYLPLAHVFERLAGHFEIFAVGGTVCYAESPDTLRDDFGLFEPTTATSVPRVYEKMYDAIREQASESAAKKRIFDWATGVAREYHEADRPGLTTRGRYWLADKLVFSDVRDALGGNVEMLVSGGGTLSEELCTLYHGMGLPILEGYGLTEAAPVVTSNPAEEVKIGTIGPPLVDVDVKIDTSVVLDAEVTDVFGETGELLIKGPNVTDGYWNMPDATERAFTDDGYLRTGDIVTKRPDDYLTFHERSKQLLVLRTGKNVAPAPIEDAFVDSQIVEQAMVVGDDRKYVGALLVPNLDAIRSWAESNGEDLPADDQALCQHDVARERVQEEVDRINEGFEPHEQIGDFRLVPTEFTEENGLMTPTLKKRRSTIQERFESLIEDIYASDTTEANAPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V9</accession>
    <name>R4W7V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445008.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00795"/>
    <dbReference type="EnsemblBacteria" id="AGN00114">
        <property type="protein sequence ID" value="AGN00114"/>
        <property type="gene ID" value="L593_00795"/>
    </dbReference>
    <dbReference type="GeneID" id="16182114"/>
    <dbReference type="KEGG" id="sali:L593_00795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.163"/>
    <dbReference type="eggNOG" id="arCOG04445">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_0_2"/>
    <dbReference type="OrthoDB" id="85263at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="23751" checksum="D31F7E05FC7BEABC" modified="2013-07-24" version="1">MSDSPQQPDVDSKALDGPHPEERPEPTGKRNAQGIRIDPEAEAEPEPEVATLSVLVLHEPGVLAQISSLFSRRQFNIESLTVGPTENPDRARITLVIEETRPGIEQAKKQLAKLVPVASVRELERDATLRELALIKVSSDHPDKVQSMAEMYGGQAVDAGAETITVEITGQRPQIENAVEAFERFGVREVTRTGTAALARGTTETAAHDHPANAPMNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W9</accession>
    <name>R4W7W9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445028.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00895"/>
    <dbReference type="EnsemblBacteria" id="AGN00134">
        <property type="protein sequence ID" value="AGN00134"/>
        <property type="gene ID" value="L593_00895"/>
    </dbReference>
    <dbReference type="GeneID" id="16182253"/>
    <dbReference type="KEGG" id="sali:L593_00895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.184"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_2_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="32070" checksum="1535E5F4BCB3E298" modified="2013-07-24" version="1">MESVLITGALGLVGRWAVDRFAEEYDVIAVDRTRPDDPRADVEYRAADLTEQGPAWELVLTEEPDAVVHLAAIPAIGMRAGAETFTTNVTAGYNVLTAAGEAGIPIAWASSECAYGENFADPPRPPEYLPIDTDHRTDPEDPYGTSKVALEAVAASVARKYDTKVTTIRPSWVQEPGAYHTKEGRAEFDPDDPGRHGNYWSYVDVRDVVELFVSALEVGHDGHEIYNAVADENFIDYPTVDAIESGYGTVPQPCNIEGDECAYSNAKAEAELGWSPQHSWRTAEDEDVPRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W807</accession>
    <name>R4W807_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport ATPase 8 ( substrate arsenite)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446292.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07255"/>
    <dbReference type="EnsemblBacteria" id="AGN01398">
        <property type="protein sequence ID" value="AGN01398"/>
        <property type="gene ID" value="L593_07255"/>
    </dbReference>
    <dbReference type="GeneID" id="16179940"/>
    <dbReference type="KEGG" id="sali:L593_07255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1481"/>
    <dbReference type="eggNOG" id="arCOG02849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_4_0_2"/>
    <dbReference type="OrthoDB" id="84406at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="324" mass="36347" checksum="509B896915BBBE98" modified="2013-07-24" version="1">MARFRFFGGKGGVGKTTVSSAYGLKCANAGLETLVVSTDPAHSTSDVFDQQFTDEPEPVEAYDDLHAMEIDPEEEVQNHLQGLRRQLGEQLSPAMVNEVSLQLEMAHQTPGAYEAALFDRFIEVMQQSDPYDRVVFDTSPTGGTLRLLALPEYLEQWIDRLLHKREKSIDYYEKAAVGKQQARRMKEGDPILQRLHERKERFAYAGETLREQATFTFVLNPDELSMRETTRAIGGLEDTELTVDGLVVNKLTPEPDPDEQGRGGTFLRDRVETERERLADIRSDFTVPVVAEIETRVREVKGSLLADVAEEIDIDPTAEIAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W816</accession>
    <name>R4W816_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tmcA</name>
        <name evidence="12" type="ORF">L593_01330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01330"/>
    <dbReference type="EnsemblBacteria" id="AGN00219">
        <property type="protein sequence ID" value="AGN00219"/>
        <property type="gene ID" value="L593_01330"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.271"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="430"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="9">
        <location>
            <begin position="541"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="787"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="824" mass="88564" checksum="D69276EF638FDC44" modified="2013-07-24" version="1">MDLAALARSLRSEAERSEERRGIVLAGEREAGLEAARLVLGAAEIEFGDVTVVGPPNQLPADTVSTNRADKLLGTTKDAVVLDAHEELRPNAVGQVVGAVDGGGLFVVLAPPLSQWAERRDGFDERLAVPPFERRDVGGRFKRRFLERLQVHRGIAIVDVDGEWVEDDGLTDPAPRLEDGRSRRGPPKESTFPPSVYDRCLTGDQAAAVGAFEVLNPTDTRATDPRAIVLEADRGRGKSSTAGLAAGALAVDGADVLVTAPQYDAAAAIFERAAEVLADLDVAVDSDGEPPKELRVGRDPDDTDDERESASGHVRFRTPSDAVEVAGDADLVIVDEAAALPVARLEAFLAADRVAFATTIHGYEGAGRGFSVRFRDRLAESRHDVDEVRLDEPIRYAAGDPIEAWAFDALLLDARPAVDQVVEDATPGSVEYRRLPPEDLLADEHLLREAFGLLVLAHYRTEPDDLARLLDAPNVAVRALVQDGHVAAVALLAREGGLGPDRRAAMYDGERIRGHMLPDVFTSQLRDERAAIPVGARVLRIATHPAARRRGLGSRLLARLRTEATDGLPEWNGAPRPAEASDRDGLDWLGVGYGATPDLLRFWASCGYRTVHLATTRNDRSGEYSALMVDPISEAGQELHDRTARRFGGRIGDVLGDALDDAEPDVVRAALSATDATAAPPLNLTDWEWRVVASAAYGPGLADVAPGPFRSLAARHLIDPLDPEALDDTGERLLVRKALQSWDWDAVASDVGYHSTGMAMRDYGDAFEPLVSLYGTDVALEERARYVEADETPALEGETLPGSGANADEPGTAEQHLDEPDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W821</accession>
    <name>R4W821_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07440"/>
    <dbReference type="EnsemblBacteria" id="AGN01433">
        <property type="protein sequence ID" value="AGN01433"/>
        <property type="gene ID" value="L593_07440"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1520"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="27368" checksum="BC16734A6E76E9B8" modified="2013-07-24" version="1">MPAVTVEDVVKRYGGGRFPRLGGSSRGDASGDRTAGDDASDRDGAGAVVALDGVSLTLERGEFRGLLGPNGSGKTTLFRLIAGLERPTAGTISRPDATVGYSFQRPCFFADLTVSENLRVFHSLQDDPPGWDWVEDLIDGLRLDPAVHRVAADLSGGFSTKLDLALGLLSRPDVLLLDEPFTDVDDYSRRRIRAFLEDYQRDDRTILVSTHNVEDFAPVLDRVTVILDGTVRFDGEPAEDVLDQYRDILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W853</accession>
    <name>R4W853_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445218.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01865"/>
    <dbReference type="EnsemblBacteria" id="AGN00324">
        <property type="protein sequence ID" value="AGN00324"/>
        <property type="gene ID" value="L593_01865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182377"/>
    <dbReference type="KEGG" id="sali:L593_01865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.377"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_1_0_2"/>
    <dbReference type="OrthoDB" id="116265at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
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            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="38338" checksum="5867DAD947BFBA40" modified="2013-07-24" version="1">MLLVLCVDLDDDIGRKTGIETPVVGRECVEEAAVALATADPEDSDVNVLFKGVNVDTEVTDESVVVAAVAGENGDDVRANRRVGEEVDEILAGLETGEEVRALVVTDGAQDESVMPVIRSRVQVDGVRRVVVRQAQDLESMYYTIKQVLDDPETRGTLLVPLGILLMIYPLAVVASYFDMPGVVLGLTSGLIGLYLLGRGLGLGSTLDRTVDRLRTGLYDGRVTIVTTMVALVIMLVGGINGLEQLDATRADSDTALGAIEIGAAIAYGAITWFAAAGLTTSFGQITDEYLAGTMEWRYLNAPFYVGSIAIVLYAASGYVIDQVSLSFLAVALAGGFFLGVASTLTFAIAESRFPRDADPAS</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="143" mass="15828" checksum="B9794FED38A9E0AC" modified="2013-07-24" version="1">MAILVAYDGSDPAQEAVEEAITVYDDEIVLLRVLELSSGSIAAGVDLLQERIKEERDEQARELSEAMKELIDDADVEFTIETVVGQPSRAIVDYAEDHPEIDRIVIGSHGREGVSRVLLGNVAEKVVRRSPVTVTVVREEQRE</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10073" checksum="AAF7D0A3B20F2F57" modified="2013-07-24" version="1">MACPVCDSTETSTINVRVSKESDVSKLVGSTWGGRNVARCDGCGVLYDHQVAANGADADESQATDRSINCPDCGSPNPSNRANCTYCDSALEPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y8</accession>
    <name>R4W8Y8_9EURY</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="39"/>
        </location>
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            <begin position="45"/>
            <end position="62"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN01059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="7448" checksum="58753166BA8A0CB4" modified="2013-07-24" version="1">MEQTIPTSGYKSSVTDHRSIGGTIVFVAVLAALLLAAAYPALATATALGAISAHVLGTAIAARRRHKRRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W952</accession>
    <name>R4W952_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="73"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10965" checksum="B751D56912A0629F" modified="2013-07-24" version="1">MPEPKSAFDGLYPCDFYEPAELLEPDQCYTVYEIARLLQDLDPDAGLEPETEDVLLDWAIPWIMTNAEDLVVADPRSDDEPGYYGLRRPEDLPESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W953</accession>
    <name>R4W953_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12200"/>
    <dbReference type="EnsemblBacteria" id="AGN02383">
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        <property type="gene ID" value="L593_12200"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12200"/>
    <dbReference type="HOGENOM" id="CLU_242957_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1555" mass="174959" checksum="8F5D6A64E678B15C" modified="2013-07-24" version="1">MSDSEGTRKVRFELDGETLLVANTGRQIDEDDVKALCTMSYTTKEASSDAEQEAPIGHKGRGFSSVLDLTNRPQVFSTGVSFEFDRGDARDAILDAVEEHDEWSEPDIDGIPLMRLPFPPDETPPRVQELLEQEYNTVFRFELKSSSIREDTITAISELDEHTAVFLQNLEELELSLDGSTEEWRIQRDVKRTESVQSDLEFVTVEHEAETQESASTTFALFSRLRIPIGNNTGGIDANTWGEVDHTRIGVALRVTRESDGIHLKRLRERPFLHVFLPTEERCPIPVLANGAFYTKISRTSVDVTAGAENYNGFLVEQIADLLATDVVGYAKETATSAGEILGWLDFTHLTEESRNDDDSLEGRFINAVKTAFADVAFLPAFSDADGDASLRSIREAVIPYYAETRPDIAGYVARIHGATRLEVSEVDSQGYFLQTKLLTPSHARVLDSLGADTLSARDIPLVLGAVSDSRSPLNKYPEPVDELAVDPILQVLIWVFETISDQDDVLSEFKAACQGASVFPVGRPTEAGIVRHVARDSGGVRELFFPPQNDIPDVDLPGIEFLSPPLYRPKANVDSRTQSNLVTELKPALESIWGVNEFEFEEVARAALFPVLPSPQQLDADDTPLRKRSILELVWRLAGESVDAAAPLPHIERTQTLHRLCLLPVPTRDGDWEPACRVYFGSDWQPDASAATQVEPLFDAAGIEDAHYLAPPDTFPGIEHPADVVDEPDIGEESEFDEWRNFFQWLGVSPHLRLKPFFDPQTRRRLRSTIGIERPDARSELDALDEDLWTEYQHHLTECLDQAGGQRGEYDSIYQMQSIEFLSQFLEAAGNVENTVEGESVSSSVGEQLLKHIGAWWRESFQKYRNPVLATHDVQSFGRRNQNCPAESEKRRVGLNLWLWQLKNARWCPTEHGVRRPDEAWLPTESVHSRFQLSGNSLLPVIPSNVAEQTRDAAGFFDAVGVRRELSQSTFRPRDARTIVGTIANTFTDADGNLTATAAVGDSLRQIKSAYRYTSELLPALPDQQRDIKDEDWQTSQTGLEDVGVLCRYPDGEFEIIRAQDAYFVSAPDVLEQIPIPSLPVFVLQETEAVGFGVHFGMRDLERAADSTPRFLDERPAVREQLIQELKRAAPYILCRLEAERQSQELITRDLNGLRAFCTDLEIVDSIEVDYEFPGENVAPVTSNPPYYLDRRDRARSEPAIPIVRAAENDDEQYRYLARALCGALNVTQFEGVVTMLTATDDSDRRDYLRLAGAPSSIDEIESKRQALREDTAEPLEAPIVNPSDYTDEDVEYKPDNSPDPAREPIKDRTPQRQERPIYEPGELAIAGDRETIIVEPAEENGDEDDYSDTRESQGGGSNPDMKYRTVVDKLGMQITMEYERARLREEFDFESRDTSPEEYVFKVHTEQAIQDARRSDSNAAPVIKKLVEEVGLPLPYPGFDILTVNPDTGKADRLIELKSSGHDTRTPGISWNEWKTARTKDVSDRFYLYIVGNLRKDIRSDPYVRAIRNPFELLRPETEEHSETKREVKVDITNFRKRGEIQETPLADVTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W972</accession>
    <name>R4W972_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Htr-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_06385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06385"/>
    <dbReference type="EnsemblBacteria" id="AGN01224">
        <property type="protein sequence ID" value="AGN01224"/>
        <property type="gene ID" value="L593_06385"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1301"/>
    <dbReference type="eggNOG" id="arCOG02387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="263"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="388"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="673"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="869" mass="97383" checksum="C93958BB785380D9" modified="2013-07-24" version="1">MARSISILHVEDDSSFASLAAEFLEREDDRFEVEPAASASEGLELLDAGDYDCVVSDYDMPGRNGIELLEAVREDYPSLPFVLFTGKGSEEVASEAISAGVSDYLQKGTGTERYELLANRIATHVERTRTQRDLERRESQLRTAQEMADLGRWHYDLVEDDLVWSDAVADIFDLPDDVSMTFESFLEYVHPDDRDHVLESWDRALKGDTYDIEHRILTGSGETRWVRERAEVDFDDDGEPVHALGVVQDVTDRKQREQRLREERDRREALFENPTDPVIEIEFDDRTPIIQDVNDTFETLFGHDREAVIGEPVSEAIVPPDSESQRHHDEITAQVLQGEPVVSEVRRQTHDGPRQFLLRVFPFEVSDTSTGTYAIYADLADRKQEQERLRRYQRAVEASGHSIYWTEPNGTITYVNPAFEEKTGYTAEEAIGQTPSILKSGEHDSEYYRDLWQTILSGDVWQSEIVNTTKSGERYVAHQTIAPVTNDGEIEHFVAVNADVTERKQYEQEIADLHRTATELVGADSRQAIYDRTIEAAEVLLDFGSAAIATEADGKLHVRSMSENVPLEERPSLPVEEGLAGKTYRTGESYLVDDAAVDETAAPQSEAIRAALSVPVGDYGVFQVTDDRPGAFDERDLELAQLLVLHTRTALRTLDRERELERRNDRLDQFARAVSHDVTNPLALATGRVELLQERYDDADLDDVQYALDRIRQLLDDLFVLSKTGEAVIDTEPVALSTVAETCFRTIRDTDATLDFDGSCEILADRTRLRQLLENLFHNAVEHGDGSARITVGVLDDRQGLYVADDGPGVPETDRDRIFEEGHSGSDGGTGLGLAIVREIAAAHGWEVTVCESADGGACFELTGVEFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W974</accession>
    <name>R4W974_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446123.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06410"/>
    <dbReference type="EnsemblBacteria" id="AGN01229">
        <property type="protein sequence ID" value="AGN01229"/>
        <property type="gene ID" value="L593_06410"/>
    </dbReference>
    <dbReference type="GeneID" id="16181688"/>
    <dbReference type="KEGG" id="sali:L593_06410"/>
    <dbReference type="eggNOG" id="arCOG10302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199464_0_0_2"/>
    <dbReference type="OrthoDB" id="127741at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="59" mass="6581" checksum="56C7E5BBF13F96E2" modified="2013-07-24" version="1">MAHVPENVKQFVCSSCNVVHAGTPIHQADGTHSWEEPPACGACEGEEFVPMEQWIRHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A0</accession>
    <name>R4W9A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MccF-like protein (Microcin C7 resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_12820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447397.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12820"/>
    <dbReference type="EnsemblBacteria" id="AGN02503">
        <property type="protein sequence ID" value="AGN02503"/>
        <property type="gene ID" value="L593_12820"/>
    </dbReference>
    <dbReference type="GeneID" id="16180203"/>
    <dbReference type="KEGG" id="sali:L593_12820"/>
    <dbReference type="eggNOG" id="arCOG04676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_0_2"/>
    <dbReference type="OrthoDB" id="37380at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="3">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="4">
        <location>
            <begin position="210"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="350" mass="38632" checksum="FF69980BCA34E770" modified="2013-07-24" version="1">MPEFVTPPPLERGDRVAIVAPSSGIAAAYPHVYELGLERLRTVFDLEPVEYPTATKDDEYLAAHPAERAGDVVDAFRDPEIGGVVTTIGGSDQLRILEHLDPAVLREHPTRFYGISDNANLTSYLWNEGVVSYYGGSVMTTLAMQGSMSEYSVEYLERAFFEESIGEIEPADRFTDQDLDWADPDTLDQRREFEDNPGWRWAGGDEPADGRVWGGCLDVLVPFLAADRYAPEASDLEGCVLLLEPSEELPSAEEVRMALLAMGERGILDAIDGVLVGRAKARSPWERPGPEERAAYRERQRETIETIVGEYNPEAPIVFDVEVGHTAPTVPVPIGGRAVVDPVDERITFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A6</accession>
    <name>R4W9A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446218.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06885"/>
    <dbReference type="EnsemblBacteria" id="AGN01324">
        <property type="protein sequence ID" value="AGN01324"/>
        <property type="gene ID" value="L593_06885"/>
    </dbReference>
    <dbReference type="GeneID" id="16181967"/>
    <dbReference type="KEGG" id="sali:L593_06885"/>
    <dbReference type="eggNOG" id="arCOG06296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136582_0_0_2"/>
    <dbReference type="OrthoDB" id="112220at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="165" mass="17247" checksum="B4910CAE33C7B90E" modified="2013-07-24" version="1">MRGSARSRGDGTHLRRGGTDRALSAVVGKTLEAGIVVLYISMLIGVLYGGVVPEYQQTTGAELGERVLAESVLEVQSAVPADPDATATVRGDLPRSIDNDPYRIVASNASIELVHEDPAIGGEVPLAMPSDVIRVEGEWESTASAVVRVETTPAGRVVRLEAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E8</accession>
    <name>R4W9E8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="3" type="ORF">L593_07495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446338.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07495"/>
    <dbReference type="EnsemblBacteria" id="AGN01444">
        <property type="protein sequence ID" value="AGN01444"/>
        <property type="gene ID" value="L593_07495"/>
    </dbReference>
    <dbReference type="GeneID" id="16182136"/>
    <dbReference type="KEGG" id="sali:L593_07495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1534"/>
    <dbReference type="eggNOG" id="arCOG00695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_2"/>
    <dbReference type="OrthoDB" id="40873at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="59"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="439" mass="45497" checksum="8BF030CF99F5EC56" modified="2013-07-24" version="1">MTTLRITGGQVLRPDMTIEEADVLVDEDEGTILAVDDPAAIDDVEGADVAAELDAEGDLVIPGLINAHTHVAMTLLRGLADDKPLDAWLQEDIWPVEAELTPGDVRVGAELGILEMIRSGTTTFSDMYFEVDRIAEAVEAAGVRAVLGHTAITVGKDDDAAAADVEESVAVAKALDGAADGRISTTIQPHSLTTVSEDALGELAEAAAQADLPLHFHANETADEVHPFVREHDERPLSVADDLGLLGENSALAHCVHVDTTEIELLAETGSGVVHCPASNMKLASGMAPIQLLLDHDVPVAIGTDGAASNNDLDVFDELRDAAMIGKLAANDASAVAAEAAVAMATTGGADVLGIDAGRIEPGAAADLAVIDLDAAHLTPAHDLVSHLAYAARGSDVRHTVCDGQVLMEDREVTTLDAAGVRERAAEHAAALVDRAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G5</accession>
    <name>R4W9G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pas domain s-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_13520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447537.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13520"/>
    <dbReference type="EnsemblBacteria" id="AGN02643">
        <property type="protein sequence ID" value="AGN02643"/>
        <property type="gene ID" value="L593_13520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180603"/>
    <dbReference type="KEGG" id="sali:L593_13520"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2767"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="429"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="649" mass="70807" checksum="EC7B7902CC05A995" modified="2013-07-24" version="1">MDAAGHRRALYEAFSGTGGAFDAKIEQALDVGIAYLEVPLGFLTRIQNGTQEIVAVVGDHDRIRPGERCPLDEAYCRRTVEKESALAVQDAAAATEIADVAYDTFELGTYLGVQVIVDGETYGTVCFADSDVRTVQFAAAEEAFVELLATLVGQELEAREYRRELQERNANLERERERFRGIAETSADILFRLDDTGTFTYVSSVVESILGYEPTTLEGSSFTEFVAEPSVEAALTEFEELLEGETVEQLEVLFSSSSGEAIPIEVNATPLRGDDGTIEGVQGVGRDVSERRERQAELRLKNRAIDEANLGISIADPQQPEVPFVYVNDGFERITGYDESFAIGRNWGLLTGEATDLDTIAAISDDVAANVSSAYEVVNYRADGTPFWNDVRISPIRDETGAVTHYLGFQDDVTGRKRTEQLVRLLNRVLRHNLRNDMTSVMGYAELLAGREDGSDYADRILDTASSLVALSEQASTLKRVAGRDRNPVRLDPDELLDAVLSSIRETEGAATIDTTIATDRGVCAGPELEDALRELVANAIAHNPSADPSVAIEVTGDDAWVDISVTDDGPGIDELERAMIERGEETPLEHGSGLGLWLVNWIVTRYGGSFRIEARDDGDGSIATVRVPGIGDEETVEEAARQPTVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K4</accession>
    <name>R4W9K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protein kinase, PrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446493.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08270"/>
    <dbReference type="EnsemblBacteria" id="AGN01599">
        <property type="protein sequence ID" value="AGN01599"/>
        <property type="gene ID" value="L593_08270"/>
    </dbReference>
    <dbReference type="GeneID" id="16180515"/>
    <dbReference type="KEGG" id="sali:L593_08270"/>
    <dbReference type="eggNOG" id="arCOG02891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028588_2_0_2"/>
    <dbReference type="OrthoDB" id="2180at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="691" mass="79644" checksum="6152A12F9F5C1317" modified="2013-07-24" version="1">MSDGTETLAELSAEYQASIPEDLREPRSFEWYLETLETDPAVARAAHQRVADMFDYYGAEYDEDRGVVEYELASEDPLHDGEHTFYGRVVHEAIHEFVNKVKSGARGLGPERRILLLLGPVGSGKSAFDAQLRRYFEDYTMRDAGRMYTFRWTNLRDVIEDQDPADDTVRSPMQQDPLVLLPQAQRDTILEQVNEALDAPYTIRNEQNLDPESEFYMDELLAHYDDDLQSVLDNHVEVVRLVADENKRRALETFEPKDKKNQDETELTGDVNYSKIAVYGESDPRAFDYSGAFCNANRGIFSGEELLKLQREFLYDFLHATQEQTIKPRNNPRIDIDQVIVGRTNMPEYKDKKGDEKMEAFNDRTKRIDVPYVMAYEDEAEIYRKLLGNADVPDVHVEPHTLEMAGLFGVLTRIEEPDADTVDVLQKAKAYNGEGDALEDVDVKKLREEAQAAAAVGEGMEGVSPRFIGDEIAEAIMDSTHRGRDYLSPLTVFSFFEENLEHHGSIAEERFAEYYRYLERVREEYRERAIEDVRNALAYDVEEIQRQGEKYMDHVMAYIDDDTVEDDITGAESEPDETFLRAVEEKLDIPEDRKDDFRQEVSNWVSRRAREGEAFDPTDNERLRRALERKLWEDKKHNINFSALVSANDLDEDERTKWVDSLMDLGYSEEGAREVLEFAGAEVAKAELEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L0</accession>
    <name>R4W9L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ArsR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446503.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08320"/>
    <dbReference type="EnsemblBacteria" id="AGN01609">
        <property type="protein sequence ID" value="AGN01609"/>
        <property type="gene ID" value="L593_08320"/>
    </dbReference>
    <dbReference type="GeneID" id="16181822"/>
    <dbReference type="KEGG" id="sali:L593_08320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1705"/>
    <dbReference type="eggNOG" id="arCOG01685">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068197_0_0_2"/>
    <dbReference type="OrthoDB" id="66988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="27150" checksum="405C3977541538FB" modified="2013-07-24" version="1">MADLLPSIPDASASDDAEPRVVGLDDEDADDVLGALSSETARELFAALTDDPGHPSALADRVDTSLQNVQYHLAKLEDAGMVEVVDTAYSAKGREMDVYAPADRPLVLFAGDEEDQTLLDRALGRLLGGVGVLTGASLAVRGLAGAEQSAQRESTVDLTGDSGDAAAPATDGGSSGAAEGDDAARDTATESADAVGDGAADYALTTDGSAGDQTVEPFAQEFAWLAEPLDATPLPPELFVFVVGATLLALAVGAWYLRERQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U4</accession>
    <name>R4W9U4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L593_09320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09320"/>
    <dbReference type="EnsemblBacteria" id="AGN01809">
        <property type="protein sequence ID" value="AGN01809"/>
        <property type="gene ID" value="L593_09320"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1915"/>
    <dbReference type="eggNOG" id="arCOG04553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1497"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGN01809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1523" mass="164555" checksum="038ADCEE84C507FE" modified="2013-07-24" version="1">MDLDGGTSHDVLADGLTLLENLEHRGTTGAEENTGDGAGVLIQRPDAFFTDVVDVDLPDIYAVGSFFLPQSEAARDDLTDLVEAELAAHDLDVLAWRTVPTDNADLGATALDSEPVVAQAFVAPAGDLETNGEIDLDGFDRALYVGRRDLETTVEDEQPAGHERFYVVSLDRKTVVYKGLLKGDQVADYYPDLTDERMRSTFAMVHARFSTNTLGAWHLAHPYRGIIHNGEFNTIQGNINWMRARETDLESDVLDEDGLEAIEPVINDPEQSDTASVDNALELLMEGGRDLPHALRMLIPEAWRGDEAMDEARREWYDFHASLVEPWDGPALVAATDGDRVGAVLDRNGLRPCRYDVTGDNTLIMASEAGALEPDFGDIVERGRLQPGQCFLADPEAGRIVPDEEVFEDLTDDRYGEWVADQQVDLETVASDDLEPANASADDGGPTDLRERQATFGYSHDELENLIEPMMKAGKDPIGSMGDDTPLSVLSDYNRPLFTYFKQLFAQVTNPPLDYIREELVTSMETRLGFQRNLLDESPKHANQLVADSPVLTDAETAAIRDLDENGLTSRVVDVTYEPPHDGAVDEAAVENADDAPDPEPDVLTFDGEYGAALEEAVERVREEATAAARDGVDVVVLSDRNTGEDRVPIPSLLATGAVHHHLVRNGLRNHVGLVVESGDPRQVHHVATLVGYGADAVNPYLAFETIADLVAGEDGADLDEAIAAYVGAIEDGLLKTMAKMGISTVESYQGAQIFEAVGLDSDFVAEYFEGTENRTGGIGLPEIEMDLLDRHAAAWTDADIDRYGEFEHRSDGIHHQWNPETVGTLQRAVRTGDYETYTEFAELINDQGDTLQTLRGLLEFDDEDRESIPIEEVEPVHEIVQRFSTAAMSLGSISPEAHECNSMGMNRLGAKSNTGEGGEPPERFGTEKECNVKQVASGRFGVTSHYLTSADELQIKMAQGSKPGEGGHLPGKKVNEMIAHVRYATEGVGLISPPPLHDIYSIEDLKQLIHDLKAANPEADINVKLVAEAGIGTIAAGVAKANADVVHISGHSGGTGASPKTSIKNAGLPWELGLAEANQMLVETELRDRIRVSADGGMKTGRDVAVAAMLGAEEYVFGTAALVTGGCVMARQCHKNTCPVGVATQREQLRERFPGQPEHVVNYMTFIAQELREIMAELGIETVDELVGRVDLLDQRDDVEHPKAKNVDLSEVLAEPAGDQRRKVREQTHEVDEQLDWDLIDDAEPAIEDGQAVTLDAEISNADRAVGATLSNAVVKEHGGDDLPDDLISVDLDGTAGQSFGAFLTSGVSMHLTGTANDYVGKGLSGGKITVSTPADAGYDPTENVAIGNVALYGATQGEAYVNGVAGERFAVRNSGVRAVVEGVGDHGCEYMTGGVVAVLGDTGRNFAAGMSGGIAYVFDGDGDFDDRLNTGMVELDRDLSERDEAMLRRLVENHAAYTGSDRADELLADWETVVDQFVKVMPEAYSRVLVENDAEDVRDHLPEPAAEPTPTGDSGLAASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9W1</accession>
    <name>R4W9W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase-like FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446788.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09745"/>
    <dbReference type="EnsemblBacteria" id="AGN01894">
        <property type="protein sequence ID" value="AGN01894"/>
        <property type="gene ID" value="L593_09745"/>
    </dbReference>
    <dbReference type="GeneID" id="16182651"/>
    <dbReference type="KEGG" id="sali:L593_09745"/>
    <dbReference type="eggNOG" id="arCOG00512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137731_0_0_2"/>
    <dbReference type="OrthoDB" id="110669at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="153" mass="16806" checksum="A13AEB20206ED763" modified="2013-07-24" version="1">MSLSELQQIGVESMDDAAIDQFLATHGVGVLALPDTPAPYLLPMSFGYDGEGSLYFTYVLGEDSEKARLSERADAARFLVYTADSPFHWQSVVMTGTIAAVPREQWDDLTLENAWRPAILEAADLSGGVAVYRFEIDEREGYRHTGLPPGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X7</accession>
    <name>R4W9X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Circadian clock protein KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10145"/>
    <dbReference type="EnsemblBacteria" id="AGN01974">
        <property type="protein sequence ID" value="AGN01974"/>
        <property type="gene ID" value="L593_10145"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2091"/>
    <dbReference type="eggNOG" id="arCOG01173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022420">
        <property type="entry name" value="Circ_KaiC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03880">
        <property type="entry name" value="KaiC_arch_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="172"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="43550" checksum="5C3E2A8E9ABED3E0" modified="2013-07-24" version="1">MSDEDWFESAVGSDDDGDADDNGDARDGDADAERVDESDGAASGDEATGVTENGADEEEPDALETPGFAPSSDEDDLDDRIPDLGDDLGDSLGEEPLSAEDIDPDLADEEDGGGLFEDDFTAALQEAEDEGFGMGGNAEPTDPAFSMGTDAGGGFGDVGVTDLDDDPDSDIPRIDLGIEGLDEMIQGGVPERSLMVAIGSAGTGKTTFGHQFLYGGLQNGERAVFIALEESRERVIRSASEKGFQFDEYVDDGQLAVVDIDPVEMANSLQTIRSELPRLIDEFGADRLVLDSVSLLEMMYEERATRRNEIYDFTRSLKEAGITTMLTSEASEETPYASRHGIVEYLTDAVFVLQYVRPSDFRETRMAVEIQKIRDANHSREMKPYEITNEGIEVFRQANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA69</accession>
    <name>R4WA69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02434">
        <property type="protein sequence ID" value="AGN02434"/>
        <property type="gene ID" value="L593_12475"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12475"/>
    <dbReference type="eggNOG" id="arCOG06222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135431_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="143" mass="16155" checksum="6005C602BF4BB812" modified="2013-07-24" version="1">MNYDLGLVRTDRGRRIELGREVPVSAAAAWTVLSEVAYWNAWGPPVTDVEYPDERVSPQTSGHVRVFGLFWVPFRIETVDGMEWTWSVRGMTPPADGHGVEDLGDGHSRVFLQLPLWAPWYLLVCAVALRRLGKVARQEGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA85</accession>
    <name>R4WA85_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447408.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12875"/>
    <dbReference type="EnsemblBacteria" id="AGN02514">
        <property type="protein sequence ID" value="AGN02514"/>
        <property type="gene ID" value="L593_12875"/>
    </dbReference>
    <dbReference type="GeneID" id="16180146"/>
    <dbReference type="KEGG" id="sali:L593_12875"/>
    <dbReference type="eggNOG" id="arCOG05411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846271_0_0_2"/>
    <dbReference type="OrthoDB" id="28854at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="37069" checksum="8902B84A54434256" modified="2013-07-24" version="1">MVTTLDNTEYADVRGFNYQPSHASHGMEIWGTDFQPSLMRKELWIGNQHFPGMNTVRLWLSHDAYLRFPERMPERVGEVLDMGADYDVEFIVTLFNGWSSYPQLGGLHPQSLREWHDGTLYREAFEPYVDAILGEHADHDSVLAWDLCNEPLLSVQNRDGLADIEVDRSLVIYRFLERVYEQILTHDPEAPTTVGTMSTPVGVELFEPISEVLSTHPYYSWNRGDTPEGLAETLDEIVAIANDAGKPLLATETGWGALDDEKRAEVLDVEFSALDERDVGFTAHLLHHTPVADGHREGHGPIYDAENMSFVDPDGSLRAHHGLFNDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC1</accession>
    <name>R4WAC1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ORF">L593_13775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447588.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13775"/>
    <dbReference type="EnsemblBacteria" id="AGN02694">
        <property type="protein sequence ID" value="AGN02694"/>
        <property type="gene ID" value="L593_13775"/>
    </dbReference>
    <dbReference type="GeneID" id="16179918"/>
    <dbReference type="KEGG" id="sali:L593_13775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2818"/>
    <dbReference type="eggNOG" id="arCOG01037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OrthoDB" id="110333at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="189" mass="20895" checksum="74E413DBFCB796FF" modified="2013-07-24" version="1">MFITVSGPPGSGKSTTAAALAEQFGLEHTSGGDIFRGLAEEKGISLAELNERAETDPAIDRDLDRRLHEIATDAEDLVLESRLAGWLSGDHADFRIWLDAPVAVRAERIAEREDKSVEQAREETVEREASEAQRYLEYYDIDIEDLSIYDVALNTARWGEDDVPELLASAIERHDPAVDEGKAPVGFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF4</accession>
    <name>R4WAF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447753.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14615"/>
    <dbReference type="EnsemblBacteria" id="AGN02859">
        <property type="protein sequence ID" value="AGN02859"/>
        <property type="gene ID" value="L593_14615"/>
    </dbReference>
    <dbReference type="GeneID" id="16181983"/>
    <dbReference type="KEGG" id="sali:L593_14615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2984"/>
    <dbReference type="eggNOG" id="arCOG08124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084426_0_0_2"/>
    <dbReference type="OrthoDB" id="51041at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="28312" checksum="3AC92F38ADC2E9D1" modified="2013-07-24" version="1">MASQQVTVWNEFVHERENDAVAEVYPDGIHDAIATGLEDRGYETRTATLQEPEHGLTEAVLEETDVLTWWGHTAHDEVEEEVVERITERVRDGMGLIVLHSGHYSKPFKRLMGTSCSLKWREADDRERIWVIEPGHPIAQGVDDCIEIDAAETYGERFDVPAPDELVFTSWFQGGEVFRSGCCYRRGNGRIFYFRPGHETYPIYHREDVRDVLANAVEWAAPVANPGTSLQGNQEPREDVDIESDSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG7</accession>
    <name>R4WAG7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_14950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447818.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14950"/>
    <dbReference type="EnsemblBacteria" id="AGN02924">
        <property type="protein sequence ID" value="AGN02924"/>
        <property type="gene ID" value="L593_14950"/>
    </dbReference>
    <dbReference type="GeneID" id="16181598"/>
    <dbReference type="KEGG" id="sali:L593_14950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3053"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_2_1_2"/>
    <dbReference type="OrthoDB" id="24701at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="656" mass="71390" checksum="D08F06A33792E189" modified="2013-07-24" version="1">MEFEEINSIAVLGAGNMGHGIAEVAAMAGYEVTMRDIEEDLVQDGYDSIEWSLNKLAEKDQLTQEEADAALDRVTPVVDLGEAVGDVDVVIEAVPEVMDIKKEVYDEVEAHAPADAIFATNTSSLSITELSEVTDRPEQFCGMHFFNPPVRMQLVEVISGAHTSGETLDTIEELAEDFGKTPVRVRKDSPGFIVNRIAVPQMNEAAWLVHEGEATIAEVDSTTKHDVGLPMGAFELSDMVGLDVSFDVLEYVNGELGKAYEPCPILEEKVEAGELGQKTGKGFYDYEDGDGVQIPRDEGREDLEAILLAVAANEAAKLVGEDVADPAEIDEAVMLGLGWPNGPAKLADEYGVDELVDALDEWHDRYDHPRYEAADPLREIAEDGGFYGGDDSNDDAMEYETIAVSVEDAVGHIEIDRPHRMNTITVDMLDEIDAAMSELETHEDVRAVLITGAGDRAFSAGFDASTAAAGSGIQAQEMSRKGQQAFGRFEESPMPVLAAIDGYCLGGGMELATGADLRIASEGAQFGQPEHNLGLLPGWGGTQRLREIVGEGRAKEIIFTARDDYSPDTMYDYDFVNEVVAPDEFEDRAWELARDLASGPPIAQKFTKFAMHAGRDDTDAGLEVENFAFGHLFTTDDMWEGLAAFQEDREPEFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSA4</accession>
    <name>R4VSA4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ORF">L593_00725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444994.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00725"/>
    <dbReference type="EnsemblBacteria" id="AGN00100">
        <property type="protein sequence ID" value="AGN00100"/>
        <property type="gene ID" value="L593_00725"/>
    </dbReference>
    <dbReference type="GeneID" id="16182228"/>
    <dbReference type="KEGG" id="sali:L593_00725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.147"/>
    <dbReference type="eggNOG" id="arCOG01704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OrthoDB" id="56027at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="183"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="188"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="411" mass="42461" checksum="01F5B0DC966383C2" modified="2013-07-24" version="1">MLEGVNVALGVTGSIAAVRTVELAHELRRRGAEVRAVCTHASTGIVNPWALEFATGRDPVTEITGAVEHVELCGRDGWADVLLIAPATANTIGKMAATIDDSPVTTCATTALGADVPVVVAPAMHEPMYDHPGVPQAIGTLESWGVAFVDPRIEEGKAKIATEDAIALATARAAFTDADEDTLRGESIVVTAGATAERVDPVRVLTNRSSGKMGRAVARACYVRGANVTVVHGPVGPRPFSNSGANPKADDTGVPYARLVEVDDSEAMLEALEDAIADADALVAAAAVGDYTTPKHADKLRSGESRSLDLEPTPKLIDGAREAEPSLPIVGFKTETSGDDDAMVAAARAIMERADLDLVVANDASVMGADETRALFVDSVEDVDGSPVSSVSGSKAAVGERIADRVAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSV8</accession>
    <name>R4VSV8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-peptide hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acylaminoacyl-peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_01585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445164.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01585"/>
    <dbReference type="EnsemblBacteria" id="AGN00270">
        <property type="protein sequence ID" value="AGN00270"/>
        <property type="gene ID" value="L593_01585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181351"/>
    <dbReference type="KEGG" id="sali:L593_01585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.322"/>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_2"/>
    <dbReference type="OrthoDB" id="15633at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="9">
        <location>
            <begin position="43"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="8">
        <location>
            <begin position="421"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="68678" checksum="A0678BC7F45CE093" modified="2013-07-24" version="1">MSFSLERYLNVRSAYGASWSPAGDRLAFLLDTTGVPQVWTVDDPGAWPAQHTTFEERVTFVDYSPTREELVFGMDEGGNERAQLHLLDVDGGEIENLTQHPDAKHRWGGWASDGERFAFASNRRDEAVFDLYVQDRDARGEDAELIAEGDGWLSLAGWSPEDDRLLVHEARSSFDHELHLCDVESGDLRQVTDHDDDIRYSSPEWAPDGEGIYLATDEDVDTRSLCYLDLASGEIETFWDGGDWEVDGVVVDEDSDLVVASRNVDGETDLAVGRLAGRTEIDPLPVPDLPGPIAGGVDVAPDGDRFSITATGRSHNANVWVVDVGDGSAAAAADASAAGFGESEAGDAPVERWTAAPTAGIPRETFRDPDLIHYETFDGREIPALFTLPDGAADATADPTDGDGLPVIVDVHGGPESQRRPSFSAVQQYFLARGYALFEPNVRGSTGYGREYTHLDDVENRMDSVADLAAAHDWLAERPAIDPDRIVVKGGSYGGFMVLAAMTEYPDLWAAGVDVVGIANFVTFLENTGDWRRELREAEYGSLEDDRELLERISPINSIDEIEAPLFVAHGANDPRVPLGEAEQVADAAREQGVPVELLVFDDEGHGFSKLENRIESTERIAAFLDEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSX9</accession>
    <name>R4VSX9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM_MT_TRM5_TYW2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445189.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01710"/>
    <dbReference type="EnsemblBacteria" id="AGN00295">
        <property type="protein sequence ID" value="AGN00295"/>
        <property type="gene ID" value="L593_01710"/>
    </dbReference>
    <dbReference type="GeneID" id="16181818"/>
    <dbReference type="KEGG" id="sali:L593_01710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.347"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_1_2"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="79"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="36322" checksum="6EF8D3D466593A21" modified="2013-07-24" version="1">MQSPCVTVPRTEGEAVRQRLEAADLLDHDRQIAVEGDAIFVPVMDPGAIPDDLDVVDHATGERDTQTVPNDLVEFEASYERIGDVVVVDEDDPERARALADAIVDSDIPVETVLNRASKIEGELRVREWEVLHGDTTETVHREYGSEYLVDLAEVFFSPRLATERHRVTEQVEADEHVFDMFAGVGPFVIPAAKRGATAVGVDKNPVAIEYLRENAERNSVAESVTALAADVRETTDGYGDWADRLVMNLPHSADEFLETAMLLAGDECVLHFYDIQHEDDPFGPGTEAIEAAADAAGYEVDVETERVVRSYAPHEVNVCLDVRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTM6</accession>
    <name>R4VTM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445484.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00590">
        <property type="protein sequence ID" value="AGN00590"/>
        <property type="gene ID" value="L593_03195"/>
    </dbReference>
    <dbReference type="GeneID" id="16180472"/>
    <dbReference type="KEGG" id="sali:L593_03195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.646"/>
    <dbReference type="eggNOG" id="arCOG04204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068244_1_0_2"/>
    <dbReference type="OrthoDB" id="92470at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010430">
        <property type="entry name" value="DUF1028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06267">
        <property type="entry name" value="DUF1028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="27474" checksum="0F3865F9EC947CD2" modified="2013-07-24" version="1">MTFSICVREPYTDPDGEEQYRFGVAVTTRLAAVGTLCPFANEYGAVATQSLVNVELGERGIEYLADGLHVEDALDALLAADEGSAQRQLHGVDRDGTFTFSGEECKPWYGHREEDDFTVAGNLLVGEDTIDATAEAYAESRHDEPAGPARPGTDGTDPAPLAERLIDALEAGHEAGGDKREELTVQSAALIVTRTEDREFSPSYADLRVDATETPIDDLRETYELAHDSYVQTLERYGDAYEEDDIDASGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTT4</accession>
    <name>R4VTT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03445"/>
    <dbReference type="EnsemblBacteria" id="AGN00640">
        <property type="protein sequence ID" value="AGN00640"/>
        <property type="gene ID" value="L593_03445"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03445"/>
    <dbReference type="eggNOG" id="arCOG04544">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164493_1_0_2"/>
    <dbReference type="OrthoDB" id="130562at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12068" checksum="0809FB05920418C2" modified="2013-07-24" version="1">MADPTPVDPADAYDDVEPTARDADGEVPDLPRDLSIQIPPSATTEEAAAIVAAVGAHIRDREAAAAAAAAGGEPSWEGERFTFAGRIEQLQGRSVRVPADAPRDAWTASGRTDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU91</accession>
    <name>R4VU91_9EURY</name>
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            <fullName evidence="9">Na+ antiporter</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">L593_04070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445659.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04070"/>
    <dbReference type="EnsemblBacteria" id="AGN00765">
        <property type="protein sequence ID" value="AGN00765"/>
        <property type="gene ID" value="L593_04070"/>
    </dbReference>
    <dbReference type="GeneID" id="16180815"/>
    <dbReference type="KEGG" id="sali:L593_04070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.827"/>
    <dbReference type="eggNOG" id="arCOG01961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_1_2"/>
    <dbReference type="OrthoDB" id="74665at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="8">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="578" mass="61288" checksum="D8CA84C1FE5FDC3E" modified="2013-07-24" version="1">MAPGAVDVAILVDLIDVFIIAAAVGIFVAKVGDFPYTIALLLAGIAASVIGIEVAIELSHDLILLVLLPPLLFEGAATTDFERLRRNLLPILSLAVVGLVGSIVLLGAAGQYVFGFDLLLALLFAAMILPTDPVSVLALFEDLGAPDRLAVLVEGESLINDGVGVVLFSALLARVSAEAAGDATGPALTTLDGLGDVGLNVLVVSGGGLLVGLAAGFATYSVMRGLDDHMTEIVLTIVLAYGAFVLAEHYFHVSGVIATVVAGLFIGNRGAEYAMSPQTKIAIFTTWETGAFIVNTFIFLMIGVTVPISSVVEHGWAILLAIPLVLLARAVMVYPIIATTNRATRPSVPLAYQHVWVWGGLHGSIPIALVLGLPPGTPEREMLRAMVFGVAAFSLVVQGLTMGPLLDSLGVVTRSDAEELFELLIGRARAVDAALEAAEDLNERGDIPQQAYEEFTAEYEREKAALAGAIRELLAETPELRHEQILAGERRLLQREKSALIDAARSGVVADDVGERLLEEVDLKLDYVHDGQSTVASDEEAFEEFWRQRADEYGLDVDRQHLDDAGTEDTPGSESAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM5</accession>
    <name>R4VUM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444855.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00030"/>
    <dbReference type="EnsemblBacteria" id="AGM99960">
        <property type="protein sequence ID" value="AGM99960"/>
        <property type="gene ID" value="L593_00030"/>
    </dbReference>
    <dbReference type="GeneID" id="16180609"/>
    <dbReference type="KEGG" id="sali:L593_00030"/>
    <dbReference type="eggNOG" id="arCOG03366">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092684_1_0_2"/>
    <dbReference type="OrthoDB" id="82670at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGM99960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23112" checksum="B93C6B6025F90456" modified="2013-07-24" version="1">MTDALAVHLNRSKHHAIEPASDSFETDGPFVVRIQNHGEGSHVHCSLSGDLATTATITDGNPFLEPDDVVDVPIDVRTDLRPARGTLELSTGYGRESVAVDVLVRESGALATSPIEHEQEDDGAEASRSTGAPVAAEDSTGPPETEYDTSTAVEAVRSSLQSFAPRADVWNVLLFVLAAIAIVIAAFAWGYFDSLAVKLGVVLVFATVQAAFLSLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUW1</accession>
    <name>R4VUW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445914.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05355"/>
    <dbReference type="EnsemblBacteria" id="AGN01020">
        <property type="protein sequence ID" value="AGN01020"/>
        <property type="gene ID" value="L593_05355"/>
    </dbReference>
    <dbReference type="GeneID" id="16181337"/>
    <dbReference type="KEGG" id="sali:L593_05355"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1094"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="27788" checksum="2E97F33777016522" modified="2013-07-24" version="1">MPDNVQPTPQREYFDFENEVAFVSGAAGGIGRATALAFAQEGAAVVVADIDEAGNRETAERIDALGSDALAVTCDLREPAEVQAAIERTIDEFGRLDYACNNAGVEQRSVKTADLDVEEWDRLLDTDLRGVFLSMKYQIPPIREHGGAIVNISSGAGIRGFPESGYVAAKHGVVGLTKSAALEYADTDLRINAVCPGIIDTSMMDRVTDDREGGRQSVVEQEPIGRMGEPAEIANAVLWLCSDAASFVLGHAMVVDGGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUW9</accession>
    <name>R4VUW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk potassium uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05405"/>
    <dbReference type="EnsemblBacteria" id="AGN01030">
        <property type="protein sequence ID" value="AGN01030"/>
        <property type="gene ID" value="L593_05405"/>
    </dbReference>
    <dbReference type="GeneID" id="16181949"/>
    <dbReference type="KEGG" id="sali:L593_05405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1104"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_3_2"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="24613" checksum="5529FFD61D3B069C" modified="2013-07-24" version="1">MYIIIVGAGDIGTPLIDIATRSGNEVVVIEKDEARANRAADDFDCLVLNDNATTKDTLEDAGADRADALISTTDQDATNIMVCLLAQEFEVPSILSVVHNPEHMGLFKQIGVNTMENPQELIAEYLYRAVARPAIVDYMRIGEDAEVFEITVTENAPIVGKTIEEAAADGILTDDMLVVAIERSGVDQPITPRGGITFESGDLLTVYSAVGADPEITDIFGHYEDHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV51</accession>
    <name>R4VV51_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00955"/>
    <dbReference type="EnsemblBacteria" id="AGN00146">
        <property type="protein sequence ID" value="AGN00146"/>
        <property type="gene ID" value="L593_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00955"/>
    <dbReference type="eggNOG" id="arCOG06342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111886_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="16399" checksum="8D706C92D3249780" modified="2013-07-24" version="1">MTTAFDFQRSMIEQTHQMTHETIEAQKTAVNAMADSVATLEQVADQNVELSHEAVHAYLDAIEQVVPEAEFGDVRELVDDGYESAAEFQDETWTAVHEAVEEGVQNFETAADNYGEMVDSSFDTYLQAHEQVEASAEEFEEIDVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV73</accession>
    <name>R4VV73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446029.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05930"/>
    <dbReference type="EnsemblBacteria" id="AGN01135">
        <property type="protein sequence ID" value="AGN01135"/>
        <property type="gene ID" value="L593_05930"/>
    </dbReference>
    <dbReference type="GeneID" id="16180028"/>
    <dbReference type="KEGG" id="sali:L593_05930"/>
    <dbReference type="eggNOG" id="arCOG00773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_2"/>
    <dbReference type="OrthoDB" id="102972at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="16268" checksum="2947F68317A09CAB" modified="2013-07-24" version="1">MPTLLDSYIENRHRVQPNHANTVGTAHGGDVMKWLDEVSAMSAMRFAGETCVTARMDPIEFHRPIGVGDIAVIESYVYDTGNTSVRVRLTADRENPRTGERERTTTSHAVFVAVDENMKPTKVPDLMVETERGENLRAAALESREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVR8</accession>
    <name>R4VVR8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445245.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02000"/>
    <dbReference type="EnsemblBacteria" id="AGN00351">
        <property type="protein sequence ID" value="AGN00351"/>
        <property type="gene ID" value="L593_02000"/>
    </dbReference>
    <dbReference type="GeneID" id="16180020"/>
    <dbReference type="KEGG" id="sali:L593_02000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.406"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042504_2_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="38947" checksum="6C3A33BBD6E9EBE6" modified="2013-07-24" version="1">MTKFLTGFPGFLGAALTERLLERDESVVCLVQPEYLAEAEERAAAIVDRTDAPSTAVTLVTGDVTEPELGLDDPDDHQEATDELYHLAAIYDLGVEREPAERVNVAGTEAVLDFAIDADVDRLHYVSTCYVSGRHDGVFGPEDLDLGQTFNNHYEATKFEAEVAVQRRMDEGLPTTIYRPAIVTGDSTTGETAKYDGLYYLLDLIDRQPTIAAAPVHPPADSYEFNVVPRNFVVDAIAHLSAREDTVDEVYQLCDPSPPTVGRLTSICGDALGQRVLGVPVHARLAGRALDAVPGLADRLGLEPASLDYLGHPTSYVCPNTRRALSKTAIECPPLESYVDELVAFKRANPSIRTTAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVX7</accession>
    <name>R4VVX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445310.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02325"/>
    <dbReference type="EnsemblBacteria" id="AGN00416">
        <property type="protein sequence ID" value="AGN00416"/>
        <property type="gene ID" value="L593_02325"/>
    </dbReference>
    <dbReference type="GeneID" id="16182693"/>
    <dbReference type="KEGG" id="sali:L593_02325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.471"/>
    <dbReference type="eggNOG" id="arCOG02999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134269_2_1_2"/>
    <dbReference type="OrthoDB" id="108947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="12229" checksum="D00717019ADF82AF" modified="2013-07-24" version="1">MEVEHFDEDDATEAVDGVHLSLLAGEERMNVQGFAIEPGAVVPEHSHDNEQTGVVYEGELTFLLDDEELVVGPGDTYAIPADEPHGAENRGETTVRGIDVFSPPRTNPSWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW01</accession>
    <name>R4VW01_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Acyl carrier protein synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00441">
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        <property type="gene ID" value="L593_02450"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF35_Znr_N"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="498" mass="51177" checksum="08D7D3BDD8ECFA7E" modified="2013-07-24" version="1">MSDGSGGRTDPADQPGRADALPSIAAVGAYAPPLRIDADEIESALGRFQAPGIDEKAVPEADEDALTMAYEAARRALDAADADGDDVVHLAFATTTPPMSEEDLTARLASFLGAPGEVSTRTFTGSTRAGGQALDAAVEAGPWSDGVGIVIASDCPNGAPDSAIEHAAGAGAVALVLDLDGAGDVVERASHVDPYPGTRFRGRGEDETEALGIGGYDRATFTDVLESAAARIDVDPSSFDVAAVQAPNGKLPYRATDALGVDAETIAAVETVSALGDTGAASAFLGLASAAEDGGDRVLLATWGSGAGANLLVLDGIGSVPVESALDASGELTYPEYLRRRGVLSSGEPDGGGAYVSVPSWQRTIPQRHRLVAGDCPNCSSLVFPPDGACAECGERAESYERVELPGTGRVEATTTIGQGGAPPEFLDQQHRSGPYVSAIVAIDGPDEDDDRSVSAPMQVLSPEDREVTVGSPVETTIRRIYEQEGVIRYGQKARLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW03</accession>
    <name>R4VW03_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">L593_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01395">
        <property type="protein sequence ID" value="AGN01395"/>
        <property type="gene ID" value="L593_07240"/>
    </dbReference>
    <dbReference type="GeneID" id="16182075"/>
    <dbReference type="KEGG" id="sali:L593_07240"/>
    <dbReference type="eggNOG" id="arCOG02998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021437_0_0_2"/>
    <dbReference type="OrthoDB" id="100745at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07883">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="13237" checksum="5C316FD6797697F2" modified="2013-07-24" version="1">MGYAVVDPEDLPVAGDEAREASRRSISGEVGLRNLGAHVYEAGPGETIPLAYHFHEEQEELFVVQSGTLTVETPEETLTVEAGEVLAVEPNSPQRAFNAPNATEPVQVLAIGAPNVDDAQPYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW92</accession>
    <name>R4VW92_9EURY</name>
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        <submittedName>
            <fullName evidence="2">DNA binding protein, translation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07750"/>
    <dbReference type="EnsemblBacteria" id="AGN01495">
        <property type="protein sequence ID" value="AGN01495"/>
        <property type="gene ID" value="L593_07750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1588"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="21767" checksum="2BF734B7590B5E37" modified="2013-07-24" version="1">MTGDGATDGAPVADGDLDAAAAAIERGECVVYPTETVYGLGANAIDPDAVECVFDVKDRDRSKPVSLGVPDVDAALEFTAPTARERRFMHEFLPGPVTVVVDRKEMVPDVLTAGSNRVGVRIPDHDVALDLLERTDAPITATSANVSGTGSVRTVSELSDEVRDAVAVVLDAGETPGSESTVVDVEVGEIVRRGAMADEIEYWLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWC7</accession>
    <name>R4VWC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446429.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07950"/>
    <dbReference type="EnsemblBacteria" id="AGN01535">
        <property type="protein sequence ID" value="AGN01535"/>
        <property type="gene ID" value="L593_07950"/>
    </dbReference>
    <dbReference type="GeneID" id="16181994"/>
    <dbReference type="KEGG" id="sali:L593_07950"/>
    <dbReference type="eggNOG" id="arCOG04756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_4_0_2"/>
    <dbReference type="OrthoDB" id="66562at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="32068" checksum="C107FB5DAF98EA8E" modified="2013-07-24" version="1">MSLLDALTQAVLPVLAIATAGYLLGRIRDVAVEPLATVTIYVLTPALVFHSLATTPIGGETAVRLAIGVTAFTIGMVAIASAVARAVGQPDGTRGAMVLASTFPNAGNYGIPMAAFAFGSVGRSTAILYIVFQAVLMYTLGVYLASRGAVASPREAAIEVLSLPLVYALAAAWLARAFAVVPDADTAAMEAIQLTGDAAIPVMLIMLGIQLANTSHGAALRSAVPASSLKLFVAPAVALLIALPLGLPTGVGRVFVLSCAMPAAVTPLMLVVEYGTDREGVTAPEFVSTAILLTTLASTVTLTVLIALLQDGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWV4</accession>
    <name>R4VWV4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_03900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445625.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03900"/>
    <dbReference type="EnsemblBacteria" id="AGN00731">
        <property type="protein sequence ID" value="AGN00731"/>
        <property type="gene ID" value="L593_03900"/>
    </dbReference>
    <dbReference type="GeneID" id="16180706"/>
    <dbReference type="KEGG" id="sali:L593_03900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.793"/>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031740_1_1_2"/>
    <dbReference type="OrthoDB" id="19189at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02376">
        <property type="entry name" value="Cu_nitrite_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="39185" checksum="7E83539F4C0E1EC6" modified="2013-07-24" version="1">MEFPDSSRRGIMTALGAGAALGLAGCISTPADGEVSANESDPVTQQEEESLDAAKETDLDRIAADPEDIPDPVDWSTPRRHEISMTTTERTAEIEPGVTFDYMTFDDRVPGPMVRVRRGDTVHLTLENAEENAMPHNVDFHAVYGPGGGADDTTISPGETAEIEFTAMYPGVHVYHCAVPNMDHHISAGMYGAILVEPEDGLPEVDRELYFGQNEIYTNGAPGEEGHHSFDYEAMKAEEPTYVTLNGEAYAFTGDGYGPVTVDKGERVRIFHASGGPNLTSSWHAIGNVWETYYPNGALASDPDHYVETGPVVPGSVGAAVIDTPVPGPIKLVDHALSRVVHRGMLGVIQVEGEPEPEIFNPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWY0</accession>
    <name>R4VWY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_08850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446609.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08850"/>
    <dbReference type="EnsemblBacteria" id="AGN01715">
        <property type="protein sequence ID" value="AGN01715"/>
        <property type="gene ID" value="L593_08850"/>
    </dbReference>
    <dbReference type="GeneID" id="16182559"/>
    <dbReference type="KEGG" id="sali:L593_08850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1814"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="255"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="374"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="450" mass="47038" checksum="684DF040476569D1" modified="2013-07-24" version="1">MDVFGSSGVRGVVNQGMTPAFATQVAQAAGTVWAADRVAIARDTRLSGQMLADAVAAGLASVGTEVERLGVVPTPAAQAHAEREGIPAVLVTASHNPPEFNGLKLVAADGGGLTVETLEAVERTLIEESFETAEWDGIGACRRRTDAAANYVDAVVEAVDAERIAAADLTVAIDPGNGAGCETSPAIFRRLGCDVHTVHAQPDGRFPGRAPEPVPAELGDLSRLVRAADADLGIAHDGDADRAVFVDERGDPIDGDASLAALASAELGQGDAMVSAVNVSQRVVDAVEAAGADLDLTPIGATYLSSRVRELQAAGQSVPIAGEGNGGVFFPPYRLARDGAYGAARFLELVAERPASEIVAPYDDYHFVQANLEYEEEADRDRMIAAATAWAKGQDGTLDTTDGYRVDYGDAWVLMRESGTEPLVRAYAEARDRDRAESLLGEAVEVLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWZ2</accession>
    <name>R4VWZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04150"/>
    <dbReference type="EnsemblBacteria" id="AGN00781">
        <property type="protein sequence ID" value="AGN00781"/>
        <property type="gene ID" value="L593_04150"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04150"/>
    <dbReference type="eggNOG" id="arCOG01836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_10_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="18110" checksum="1B6E74D9CC0FCBD8" modified="2013-07-24" version="1">MIREFGESVGEAVLKRTGRAAAGVQERRPLPADLLESDDAYLAVFDVPGAAASDVQVRYSDGRVLVRVDRFRSFHDGFTMQFPGRGLSLDGEVDLPDDAVVTADEASATLTDRGTLEVRLPKVATAEVDVGLEGEGEMVADEGEMDEEETETADADTDDGGQNDDADDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXB2</accession>
    <name>R4VXB2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="11" type="ORF">L593_09650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446769.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09650"/>
    <dbReference type="EnsemblBacteria" id="AGN01875">
        <property type="protein sequence ID" value="AGN01875"/>
        <property type="gene ID" value="L593_09650"/>
    </dbReference>
    <dbReference type="GeneID" id="16180331"/>
    <dbReference type="KEGG" id="sali:L593_09650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1987"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="OrthoDB" id="111803at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="312" mass="34376" checksum="6ED653CB41E003B4" modified="2013-07-24" version="1">MTLRVTFLGTGGAVPTTERNPSALLVNREGDRLLFDCGEGTQRQLMRFGAGFDVSHLFVTHLHGDHVYGIPGFLETLDFNDREDPLTIHVPPGTKGKVRSFLESLGGWPSFPLRLSETSPGAVPLRREDYEVRAFDVDHRTNAVGYVLEEDDRKGRFDRQRAEELGVPVGPKFSTLHEGESVELDDGTTIEPEQVVGEPRPGRTLVYTGDTRPQERTVEVARNADLLIHDATFADDRAERARKTAHSTAREAGEIAQRADVRRLALTHVSSRYAHDVSAHETEANEAFDGEAFVPHDGDVVEVPFPDGGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXE8</accession>
    <name>R4VXE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04935"/>
    <dbReference type="EnsemblBacteria" id="AGN00936">
        <property type="protein sequence ID" value="AGN00936"/>
        <property type="gene ID" value="L593_04935"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04935"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="140"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="34729" checksum="C88560D81E25E4EB" modified="2013-07-24" version="1">MTVVTADASDDVERRETRNGVIVRRHGSLTPEGAIHFAPGIRRAVQQRDANLVHAHNVHSLPLPIASFSANAPVIATAYYHGASSSRWRNALWVPYRPVARRALRHARTVTAVSEWERRTIRDDFGVDPEVIPIGLETAKFRNATPIDRDRPYLLTVSRLEEYKGVQHAIRALTELPEYDLLVAGDGPYRDDLKSIASEVGVADRVEFLGNLDHDVLPGYYAGAAAYCSFSEFESFGITVAEALASETPAVVLEATALADWTKRSDVVGVSNVDTEAVAGAIEDVIGRDAPSASIATWEDTADRYEDRYRATIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXF5</accession>
    <name>R4VXF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04960"/>
    <dbReference type="EnsemblBacteria" id="AGN00941">
        <property type="protein sequence ID" value="AGN00941"/>
        <property type="gene ID" value="L593_04960"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04960"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="457" mass="51592" checksum="99DFDF72CD8FCE83" modified="2013-07-24" version="1">MKCQNALLITIDSLRADAVGSTRYGESVTPRLDEVIESGVQFTNAAANGSSTPSSFPSILTSTYPLMYGGYQYLNESRPFLAEHLSNEGFVTVAYHSNPHLGPNMNYDRGFDSFNDIGGDTNDSDMGLINRAKNYIEERIDNNSLLYSWLRRGWHLFSMSTGTAAYANATTITDNAIDWLEERDRDRRFFLWLHYMDVHYPFMPPRRHLQDLVADLPKNRQIARINGQMHENPEGLSDRDLLLDLYHGEVKYTDYEIGRLLDKLSEQGVLNETHVTITADHGESFGEHGYYGHHPNPYDELVRVPLIMNNPNSSHMGTVSDQVELADIGPTIYDSLNVSTPDAVQGDTVNKLLSDAGGRDDDDRVAICTGSPTTLASRTNRWKLIWWMDSDELELFDLRNDPKESEDVSTGNPEVVDRMKSILDDHLEEVEASEADNPNVSVSRDTKDRLRDLGYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXJ8</accession>
    <name>R4VXJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrmB family transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446874.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10175"/>
    <dbReference type="EnsemblBacteria" id="AGN01980">
        <property type="protein sequence ID" value="AGN01980"/>
        <property type="gene ID" value="L593_10175"/>
    </dbReference>
    <dbReference type="GeneID" id="16180332"/>
    <dbReference type="KEGG" id="sali:L593_10175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2097"/>
    <dbReference type="eggNOG" id="arCOG02241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082928_0_0_2"/>
    <dbReference type="OrthoDB" id="74989at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23762" checksum="9328E3D420631C97" modified="2013-07-24" version="1">MSADDTTDERDDASDDAEAGAGATRADDATDDRSRRDELTDRLSEETDRAVEEFDQRLVDLLSWMLDTETRARIYVHLRQSPHSTSDEIAEGTGLYPSTVREALAELHDEGIVERRKRQSEGAGNNPYEYAAIAPSELVGTVAERVQTELNTVFNLDRHISAGSTEPDLDEEPVTITVEDGSSSAEAAAAASTEPAVEETDETDADSPDDELLGEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXM5</accession>
    <name>R4VXM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10325"/>
    <dbReference type="EnsemblBacteria" id="AGN02010">
        <property type="protein sequence ID" value="AGN02010"/>
        <property type="gene ID" value="L593_10325"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10325"/>
    <dbReference type="eggNOG" id="arCOG08101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077326_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21503" checksum="3C8114C45C8E7209" modified="2013-07-24" version="1">MTLLETDDAPTALYRIVGRHLADEPGAPAYWLDARNAASPATIREHAPGSAARSIRVARAFTGYQHYELVRGLLGRIDPDASLVVAPNLGALYAEDDVPEYEADAMIEVVCSLLERVAAALDVPVLVTAPGSTYADRARAAADRVLTATRTSAGLRVEGPDFQTDVYWSAGGFQTTIAYWVDLLGTATSARSAPAADTTLVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXS8</accession>
    <name>R4VXS8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_05585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445960.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05585"/>
    <dbReference type="EnsemblBacteria" id="AGN01066">
        <property type="protein sequence ID" value="AGN01066"/>
        <property type="gene ID" value="L593_05585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181441"/>
    <dbReference type="KEGG" id="sali:L593_05585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1142"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_2"/>
    <dbReference type="OrthoDB" id="32623at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="14"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="605" mass="66956" checksum="711D6BA5D941F623" modified="2013-07-24" version="1">MVAPANAPADLAEEVVELAKRRGYFFQSSEAYGGVAGFYTYGPQGAGLKQNVEDAWRERYAIAEGHQEVDAPTIMPEPVFEASGHLDTFDDMLVSCAECAESHRADHLIEDAPGSTVEDAEALPIPEVEELLREYEITCPNCGEPLAGEPVEDFNLMFGTNIGPGDASPGYLRPETAQGIFVEFPRLKQYARGQLPFGVTQIGRAYRNEISPRKSIVRTREFTQAELEHFIDPELDEPDVEAVADVEVTLYSADAQQAEDGEPIETTIGSAVEDEVVESDWIAYYLGVTKRWYDRVGVDMDRFRFRQHLPGELAHYSSDCWDAEGYAAGDWIEMAGFSYRSDYDLRKHAEYADDDFTVFKQYDEPRTTKRATVDPDMSELGPTFGGAAADIAEALEAIAATDPDRFDAAAAAPAGTVEVTVGEGDDADTYDVPFEHTGYAVEEVTEAGEHLRPHVVEPSFGVDRLVYTLIEHAYREDEVDGEERAYLTLDPEVAPTTVGVFPLMDRDGMGERARDLADDLREIGLSVEYDDSGAIGRRYRRQDEVGTPFCVTVDHDTLEDGTVTIRERDSTAQVRVPADDLPRICRDLRDGVREFSALAEGQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY55</accession>
    <name>R4VY55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446080.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06185"/>
    <dbReference type="EnsemblBacteria" id="AGN01186">
        <property type="protein sequence ID" value="AGN01186"/>
        <property type="gene ID" value="L593_06185"/>
    </dbReference>
    <dbReference type="GeneID" id="16181651"/>
    <dbReference type="KEGG" id="sali:L593_06185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1263"/>
    <dbReference type="eggNOG" id="arCOG11844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932626_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="30964" checksum="059C389C7478F959" modified="2013-07-24" version="1">MTSSTPFDDYLAAGESSELVGSGTLFQEPAWTPASICVTDRRILFVPTDGGFVDVPRGQVLSIRSRPRSRRTRAEIASLGLLATGVALAGLAGAAVLAGAGTLLVPVLALLGTIGTLATAALVTRGGGLSESDATGALDRIDEVLQRGDEALERFDVPPAFSLDGEQRERLTGFVDERPVLQWAAAGLGTIGAGGLAALGAWTALLLAAGVTIGVGAGAVGLDRHRDLQRGDRARRRERVVGLQLLDGRTVRFRIDAEATIDRELSRLTARPAASRLPSADVVHAEDRSAEQSASTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYF5</accession>
    <name>R4VYF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447184.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11735"/>
    <dbReference type="EnsemblBacteria" id="AGN02290">
        <property type="protein sequence ID" value="AGN02290"/>
        <property type="gene ID" value="L593_11735"/>
    </dbReference>
    <dbReference type="GeneID" id="16182740"/>
    <dbReference type="KEGG" id="sali:L593_11735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2415"/>
    <dbReference type="eggNOG" id="arCOG04655">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144584_0_0_2"/>
    <dbReference type="OrthoDB" id="109691at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12391" checksum="2E77340376892B84" modified="2013-07-24" version="1">MNQLYVAAGGAGLLVLLGFFLLVLKRHRSSGAAASKRAHEQAQEREPPVEIGETYEFAITEFTDHHSGKQVAVGKVEGFVLFAGDVPGSASEGTVVCARVDSFNRGRTSADATVVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYM8</accession>
    <name>R4VYM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease OppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447259.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12110"/>
    <dbReference type="EnsemblBacteria" id="AGN02365">
        <property type="protein sequence ID" value="AGN02365"/>
        <property type="gene ID" value="L593_12110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180128"/>
    <dbReference type="KEGG" id="sali:L593_12110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2492"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_2"/>
    <dbReference type="OrthoDB" id="63271at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="127"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="343" mass="37439" checksum="83AA57DEA4B22900" modified="2013-07-24" version="1">MERGRITISGFDPERVTEREALSDWTDESSSETKSRWWRAWRRFRRNRSAMLGLLIVALMAAIAFFSMPVKVFGVTVQPFHLAPHRPDKILYLTNPDVSIYQQPNFEYPMGTDQNGRDMLSRVMVGARYSISIGFIVVAITGTIGLIYGAIAGYYGGWVDELLMRFVDTIFAFPGLVLALVIVTMLGKGYWELVLAFSAFGWASYARLIRGEILKVKQEEYVTAAKALGARDASVIFRHIVPNAIAPLIVQASLSIGTVVIGVAALGFLGLGFPPGTPEWGTMLDSTRQTLIQGPGGSIPWWATVYPGGAIFLFVMAMNMIGDGINDALDAQEVSTVGQGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYY4</accession>
    <name>R4VYY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447369.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12680"/>
    <dbReference type="EnsemblBacteria" id="AGN02475">
        <property type="protein sequence ID" value="AGN02475"/>
        <property type="gene ID" value="L593_12680"/>
    </dbReference>
    <dbReference type="GeneID" id="16180389"/>
    <dbReference type="KEGG" id="sali:L593_12680"/>
    <dbReference type="eggNOG" id="arCOG04801">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140264_0_0_2"/>
    <dbReference type="OrthoDB" id="116638at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="13130" checksum="0B30F698579F8BD4" modified="2013-07-24" version="1">MLLVVTYSRAARQTLRNVCNAHEETVVRRFGRAALLEETAMGAFLGLRLRAKHGADVQLERTAPFNEFEAVDADVRDAAAAYEARDRPSTPYAKFAAGTDHPDPSELRDRDVADRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ02</accession>
    <name>R4VZ02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="5" type="ORF">L593_12780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447389.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12780"/>
    <dbReference type="EnsemblBacteria" id="AGN02495">
        <property type="protein sequence ID" value="AGN02495"/>
        <property type="gene ID" value="L593_12780"/>
    </dbReference>
    <dbReference type="GeneID" id="16180165"/>
    <dbReference type="KEGG" id="sali:L593_12780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2622"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109671_1_1_2"/>
    <dbReference type="OrthoDB" id="112720at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="13764" checksum="175C2153E172BD5E" modified="2013-07-24" version="1">MAPFQVVVSDPDSGRTFQREVDGQDANRFASRALGDEVDGDAVGLDGYTIELTGGSDDAGRPLRADVDGPDLKEVLLTGGVGFEPERDGERKRVTVRGREISDAVAQINAKIVESGDTDLDELLGEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ16</accession>
    <name>R4VZ16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446385.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01491">
        <property type="protein sequence ID" value="AGN01491"/>
        <property type="gene ID" value="L593_07730"/>
    </dbReference>
    <dbReference type="GeneID" id="16182202"/>
    <dbReference type="KEGG" id="sali:L593_07730"/>
    <dbReference type="HOGENOM" id="CLU_1529293_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="17968" checksum="C6D1A28F5101BA4B" modified="2013-07-24" version="1">MNRDRPKARDHAGASTDADDDDGTDRRATDVSRRRLLGAAGTVAVAGLAGCSGILGGGGGGGSSGSGPDNVQNEVDGIEVTDATAESSGGRYSIMVTLRNTGGEDTSVLDFGYDVTLYDSSGSEIETMGTAAANRDGFYDGNPGKVEIIPQMQSEASAVDSFELTIRCEEGPYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ74</accession>
    <name>R4VZ74_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446445.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08030"/>
    <dbReference type="EnsemblBacteria" id="AGN01551">
        <property type="protein sequence ID" value="AGN01551"/>
        <property type="gene ID" value="L593_08030"/>
    </dbReference>
    <dbReference type="GeneID" id="16179913"/>
    <dbReference type="KEGG" id="sali:L593_08030"/>
    <dbReference type="eggNOG" id="arCOG03320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071764_0_0_2"/>
    <dbReference type="OrthoDB" id="26292at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="167"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="37754" checksum="353F967C304CE055" modified="2013-07-24" version="1">MSVESTLLRDPAEWNALVDRSEETTPFHRYEALEVIADHSGTTLYPYAAYKGQEPVGLFPVFALRRGPLRTVFSPPPDLEISYLGPARLDGHGAKQRKAEKRHRRFVESVVDEIETEIGPHYAHVRAGTDYDDPRPLIWNDFEPTPRYTYHVDLTPDVDDLFMSFSSDVRRNVRNAEEFDYEIAEGGPAAVERIVRSVQKRHAEQGVSYNVTPAFARDLQRIMPEGVVRAYTCELRGEFVGGKLTLEDDETCYGWQTASDLDVDLPVSDLLDWTVMQRARERGLTRMDLIGANKQRLCGYKAKFNPAVQTHYSLEVSSPATDAIKAVYKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ82</accession>
    <name>R4VZ82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447474.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13205"/>
    <dbReference type="EnsemblBacteria" id="AGN02580">
        <property type="protein sequence ID" value="AGN02580"/>
        <property type="gene ID" value="L593_13205"/>
    </dbReference>
    <dbReference type="GeneID" id="16180466"/>
    <dbReference type="KEGG" id="sali:L593_13205"/>
    <dbReference type="eggNOG" id="arCOG02155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174517_1_0_2"/>
    <dbReference type="OrthoDB" id="112213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8686" checksum="8BC97DF49148E03A" modified="2013-07-24" version="1">MTDVLAESLSEKAVMGTDGAEIGSLYNVTVDLESGQLRDLVVSPLEDGPDFEFKIDEDGHYLVPVGRVQSVRDYIVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ98</accession>
    <name>R4VZ98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08180"/>
    <dbReference type="EnsemblBacteria" id="AGN01581">
        <property type="protein sequence ID" value="AGN01581"/>
        <property type="gene ID" value="L593_08180"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08180"/>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599388_0_0_2"/>
    <dbReference type="OrthoDB" id="6904at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="456" mass="47881" checksum="C2372E978797525C" modified="2013-07-24" version="1">MLLLVAGAVVAPVSAAIAPADATAGEPPRAEAGLDQEVQRNASVLLDGSQSFAPDGEIVEYVWYVTTPDGGTITPDCDSADCSLASFQAPELGEYEVLLAVEDDDGRRQTDTMYVTTVPRGGFGVELTGPNATAAEGNLTATVAPGDADVENITWYQGDRELSNRTLPENGGIFNRSTYVVPGTTYRAVVTNSWNQTVSDSWTAPGGGGTWTPSGPSGDYPRIEGPALVTGAPDSTDGGWRYSSTPYVVRTNDRGSVTESTWTVNGESAPGGYFDSDTRLRPPLSPGPNIVSANLEVTFSETVANADHDASNVSSQDYVQNVSEASVLQRRVLVDPAPNLNASVLSQGEEEIAIRYDVEDRYNPVESLEVSISGAQAGGTGPLDKDAEGILTVPVPDGSYGSESVTVSVVDGRGQRSRVSISAEFPEMTIGDVPEHIGDMPSDESAHFGNSPVFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZD3</accession>
    <name>R4VZD3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447529.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13480"/>
    <dbReference type="EnsemblBacteria" id="AGN02635">
        <property type="protein sequence ID" value="AGN02635"/>
        <property type="gene ID" value="L593_13480"/>
    </dbReference>
    <dbReference type="GeneID" id="16180680"/>
    <dbReference type="KEGG" id="sali:L593_13480"/>
    <dbReference type="eggNOG" id="ENOG502N5N8">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369578_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="20261" checksum="9111F506B90A9162" modified="2013-07-24" version="1">MSETEATMEDGDDGSAEASTEATTTSIQEGSSGGSSLEDFVSAAEQEIIKEWVGFVTGLFAAIGIGIGLNSIIQDQWGHALMKTSVMGQSAGTPFSPFSGLGLAMNIGILLVVLLGVVFAWNIDNEEYTAIKVAAATSLVAIPVFSLVTGFLVLVPADNTSLEVVNVIVSGLGSGIAATVGASIVIFLTDSQAPDGLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZR6</accession>
    <name>R4VZR6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446600.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08805"/>
    <dbReference type="EnsemblBacteria" id="AGN01706">
        <property type="protein sequence ID" value="AGN01706"/>
        <property type="gene ID" value="L593_08805"/>
    </dbReference>
    <dbReference type="GeneID" id="16181040"/>
    <dbReference type="KEGG" id="sali:L593_08805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1804"/>
    <dbReference type="eggNOG" id="arCOG00232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_1_2"/>
    <dbReference type="OrthoDB" id="76473at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="25696" checksum="912B357FFC5CBD5A" modified="2013-07-24" version="1">MARKDYQQKLDDLRDDVLYMSELVLERLRDGLDALDRKDEDLARDVIEGDHEINQLYLDLEQDCIDLLALQQPVAGDLRFIASSFKIITDLERIGDLATNLAGYAEDAEQDRYPDVDIQSIGDQVIQMIEDTMTAFAQEDVEACREISARDDDIDALCERASQTVVRDLIEREVGPDAPQSEIEGIMQDVSRLLLTIRDLERVGDHAVNIAARTLYMVESDDELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZV7</accession>
    <name>R4VZV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HtpX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_09030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09030"/>
    <dbReference type="EnsemblBacteria" id="AGN01751">
        <property type="protein sequence ID" value="AGN01751"/>
        <property type="gene ID" value="L593_09030"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1852"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="28490" checksum="64D6411E4CF399C6" modified="2013-07-24" version="1">MALVGTILFAFYLAIATVAYAAFNIPLAIVLIGSFGLVGIQYVLGKKMALWTTGAKDMPEDGQYAQVHRSVERFSEEMGIEKPRLMVASMGVPNAFATGRRGAGVVVVSEELMSILDHDELEGVLAHELAHIENRDVLTMTIGQSIAMMVGIAVHWIVLFTGERSLANYFLGYLAGIVAQMFVMVFVMAISRYREYIADADAAQVIGTGDPLARALEKISRGAQASGNEVDDSVAALCIFGGAERLLSTHPPTEERISRLRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W066</accession>
    <name>R4W066_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447799.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14855"/>
    <dbReference type="EnsemblBacteria" id="AGN02905">
        <property type="protein sequence ID" value="AGN02905"/>
        <property type="gene ID" value="L593_14855"/>
    </dbReference>
    <dbReference type="GeneID" id="16181533"/>
    <dbReference type="KEGG" id="sali:L593_14855"/>
    <dbReference type="eggNOG" id="arCOG10129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943789_0_0_2"/>
    <dbReference type="OrthoDB" id="106645at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="13796" checksum="63B4008A8E2A90DB" modified="2013-07-24" version="1">MSTTQRQAVDHEPVQDVTAVRLDAESLESTSPEYLRDCRAGLVGEGLAPVELAVEARFDADSSLDTEAEADRIRGLIRAATFLGANRVVVRIDAASVPDAADTALRACAERARREGVGFEIEGPVTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0G0</accession>
    <name>R4W0G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10255"/>
    <dbReference type="EnsemblBacteria" id="AGN01996">
        <property type="protein sequence ID" value="AGN01996"/>
        <property type="gene ID" value="L593_10255"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2114"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="29335" checksum="13367D7A8C19D7FC" modified="2013-07-24" version="1">MTAIQAEALRKSFGDLAAVDGLSLSVEAGELYGLLGPNGAGKTTAIELLTGQLEADGGSASVLDVDPAAEPIGVRERVGVLPEKEAPPSFLTPREFFDFVGRVRGIDDATLERGVEEWAGRLGMAEHLDTLAADLSRGNQQKVMIAAAFLHDPDAVFIDEPLANLDPIVQERVKEALVEYARDNAVMLSTHHVEVAAEVCTTVGIVHGGELVAERDPSDLAPDRTLLDEFLAAVEDGHAAADGIADDGAGASAAADGAGGVSAAAPQARGSPADDPDEEDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0P1</accession>
    <name>R4W0P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447010.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10855"/>
    <dbReference type="EnsemblBacteria" id="AGN02116">
        <property type="protein sequence ID" value="AGN02116"/>
        <property type="gene ID" value="L593_10855"/>
    </dbReference>
    <dbReference type="GeneID" id="16181376"/>
    <dbReference type="KEGG" id="sali:L593_10855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2240"/>
    <dbReference type="eggNOG" id="arCOG02985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820411_0_0_2"/>
    <dbReference type="OrthoDB" id="53231at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="35771" checksum="E2C86EB6E873E749" modified="2013-07-24" version="1">MGDRDPVERAAGREQIYEVTDWEPRSFLDRFAVQAYAGVVAGSKWLVVLVALAITFAIIGLSGLDLVLEPAVTTLVGMSVLPALALFVYLHYADVTSGEPFGLLAITFLLATVTAGFAAVINSVALAGLGGVADVFGQAVALGIFFYVVVGPVEETVKLLAVRLYAYPDERFDAVIDGAIYGAVAGLGFATIENAIYITDLIQAEGGLAASSSGELGGITASRAIAGPGHVLYSGIAGYYLGLAKFNRDRAGPIVVKGLIVAALFHATYNFTVGAGAGVLVTAFPVSEFGALVAYVLAFQSAVGYYLYLKIDRYRRAFDEFDAGRVETEHLPERTEFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0Z6</accession>
    <name>R4W0Z6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_11330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11330"/>
    <dbReference type="EnsemblBacteria" id="AGN02211">
        <property type="protein sequence ID" value="AGN02211"/>
        <property type="gene ID" value="L593_11330"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11330"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="9">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="473" mass="49590" checksum="A448EF2A4765DC41" modified="2013-07-24" version="1">MSDVFTVDRLYGTLAPAEHRSRSFQNGEIPVAVYGLGKLGLPVAATLAEASGNVIGADVDPAVVRELEQGRSHVDGEPGLDELVERLVEDGSLSAVQDPSKAAARASIHVIVVPTLLDDENEPDLAALIAAASSIAAGLDPGDLVLLESTVPPGTTAEMLEPSLAAASGLDPSEFGVAFCPERISSGRALKDIREAYPKIVGGTDEAATEAAALIYEHVTDNEVIETTDATTAEAVKVFGGVYRDVNIALANEFARYADEIGVDVEEVTEAANTVPVTSILEPGIGVGGHCIPVYPHFLTKPHTVDGPVIPAARALNDDMPAYAVDRLADELAAEDVDLGDATVVLFGLAYRGDVAETRYSPSVDVAELLAQFGAEVLAVDPVLDDATVADVPTELVSVAEAATARPDAAIYATDHGAFERIDWSTFEPMVVLDGRNALDLAGTEHRQCRLGDGKTPPPASHWLANDPRRTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W142</accession>
    <name>R4W142_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11665"/>
    <dbReference type="EnsemblBacteria" id="AGN02276">
        <property type="protein sequence ID" value="AGN02276"/>
        <property type="gene ID" value="L593_11665"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2404"/>
    <dbReference type="eggNOG" id="arCOG02293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="24488" checksum="B2FB8DB40F0F85AC" modified="2013-07-24" version="1">MPGGWESEIVTEFRAVLFDMDGVLIDTEPHWKDLWRNEVFPDVADGEPSLEDVTGRSYTDSIPDLHENYTLAKEPQHYVDLVERQADDLYAEAADGAPVVHDLFDVVRDRGLAVGIVSSAPPDWIETVVDRFGLGPLDLCQSAFDAPGPGKPEPDVYEYAAAALGLDPAETIVVEDSTNGVRAAAAAGATVIRFEIGVAADAMDEATAVVHDAAELEAVLIDLLDGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W180</accession>
    <name>R4W180_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl1P</name>
        <name evidence="6" type="synonym">rpl1</name>
        <name evidence="8" type="ORF">L593_11915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447220.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11915"/>
    <dbReference type="EnsemblBacteria" id="AGN02326">
        <property type="protein sequence ID" value="AGN02326"/>
        <property type="gene ID" value="L593_11915"/>
    </dbReference>
    <dbReference type="GeneID" id="16182028"/>
    <dbReference type="KEGG" id="sali:L593_11915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2452"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OrthoDB" id="70269at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="23016" checksum="A6A0401CFF19CA26" modified="2013-07-24" version="1">MADQEIELAVSRALEESPDRNFTESVDLAINLRDLDLNDPSNRVDESIVLPAGTGQETKIVVIAEGETGVRAEEVADDVLSGDDLADLGDDDDAAKDLAGDTDFFVAEEALMQDVGRYLGTILGPRGKMPTPLSPDDDVVEVVERMKNTVQLRSGDRRTFHALVGAEEMSAEEIADNIDVILRRLYADLEKGPQNVDTVFVKTTMGPAEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W198</accession>
    <name>R4W198_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447245.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12040"/>
    <dbReference type="EnsemblBacteria" id="AGN02351">
        <property type="protein sequence ID" value="AGN02351"/>
        <property type="gene ID" value="L593_12040"/>
    </dbReference>
    <dbReference type="GeneID" id="16181780"/>
    <dbReference type="KEGG" id="sali:L593_12040"/>
    <dbReference type="eggNOG" id="arCOG08961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144578_0_0_2"/>
    <dbReference type="OrthoDB" id="98724at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11333" checksum="879A7E63A33AA408" modified="2013-07-24" version="1">MTERDGTARAITVSYPADLSKWGRSIVEGTPFRAYLRRVYDTAAVGDEWSEFVGVGCCGDSLDVPLRVEAVEGGEAIDDETAVRFREREACGLAGGWSVQSETGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1C5</accession>
    <name>R4W1C5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447285.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12240"/>
    <dbReference type="EnsemblBacteria" id="AGN02391">
        <property type="protein sequence ID" value="AGN02391"/>
        <property type="gene ID" value="L593_12240"/>
    </dbReference>
    <dbReference type="GeneID" id="16180083"/>
    <dbReference type="KEGG" id="sali:L593_12240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2517"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_1_1_2"/>
    <dbReference type="OrthoDB" id="82715at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="24337" checksum="03A59274252B4CB0" modified="2013-07-24" version="1">MRIGLLSDVHANLPALEAVLDDMPDVDSIVCAGDVVGYNPWPADCVERIRDVAAVTVQGNHDRMVETPVRYAANQMAHAGLQYALDTLSEAQLEWLRELPASTTFGNGDYLLVHSHPEHRGNYVYPEDFAELRPYLEDYDGVVLGHTHVQGKAHVDGRLVVNPGSVGQPRDGNSNAAYAVLDTEENDAELHRVHYDVDRVHHEIAVEGLPAESGDRLFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1F8</accession>
    <name>R4W1F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12485"/>
    <dbReference type="EnsemblBacteria" id="AGN02436">
        <property type="protein sequence ID" value="AGN02436"/>
        <property type="gene ID" value="L593_12485"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12485"/>
    <dbReference type="eggNOG" id="arCOG01250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045500_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="342" mass="39929" checksum="070B2186461275AA" modified="2013-07-24" version="1">MMKDNLEPISPVEAKEMYLDARKREVSQSTLDGYHYRLKHFIRWCKEVEGIENMNSLSGRDLQRYKTWRRDDGDLKPISLEGQLDALRIFIRWCGSIDAVEQDLHENFEAIMPSLDKTDEQSESILGTEQAESLIEYQRKFEYASRSHVIMEILWHTGIRLGALHALDIDDYDENAERLAIYHRPKSGTPLKNGKEGERMVALNAEVCRTIEDWRDNHRHRVRDDYDRNPLLTSRNGRMNRSSIRDAVYMVTRPCYYAAECPEGRNPDDCEAAEYGGYSKCPVNVSPHDIRRGSITHFLTEDVPEKVVSDRMNVGQDVLDKHYDKRDEEVKVEQRRGYLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1H8</accession>
    <name>R4W1H8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="2">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="2">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">folD</name>
        <name evidence="5" type="ORF">L593_12635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="2"/>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447360.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12635"/>
    <dbReference type="EnsemblBacteria" id="AGN02466">
        <property type="protein sequence ID" value="AGN02466"/>
        <property type="gene ID" value="L593_12635"/>
    </dbReference>
    <dbReference type="GeneID" id="16180097"/>
    <dbReference type="KEGG" id="sali:L593_12635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2593"/>
    <dbReference type="eggNOG" id="arCOG04538">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_2"/>
    <dbReference type="OrthoDB" id="48572at2157"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="4">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="31729" checksum="4CE1B3803111E8B2" modified="2013-07-24" version="1">MAEIIDGNAVAQAIRDDLSEEIDRLADQDVQPCLATVLMSEDPASETYVSMKQSDCEEVGIETRDVTLDAEDPAEDLYDVIEELNADPDVNGILVQLPLPDHVDKSRVLRMIDPEKDVDGFHPENVGRLVAGEARFKPCTPHGVQKLLEDAGVDPEGKDAVVVGRSDIVGKPMANLLIQKQPGGNATTTVCHSRTQNLAEKTRGADILIAAAGVPEFIDGEMVSEGTTVIDVGINSVDADTEKGYELVGDVDFDSVEPKAKAITPVPGGVGPMTRAMLLYNTVKAAGLHHDVDVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1J3</accession>
    <name>R4W1J3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447380.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12735"/>
    <dbReference type="EnsemblBacteria" id="AGN02486">
        <property type="protein sequence ID" value="AGN02486"/>
        <property type="gene ID" value="L593_12735"/>
    </dbReference>
    <dbReference type="GeneID" id="16180148"/>
    <dbReference type="KEGG" id="sali:L593_12735"/>
    <dbReference type="eggNOG" id="arCOG01461">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_2"/>
    <dbReference type="OrthoDB" id="33975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="36266" checksum="CC5C0C800E34B532" modified="2013-07-24" version="1">MAATSRAWYFAARPEGEPDLDCFDLRDHEVPDPDPGQLLVEVRYLSVDPYMRGRMRDSESYAEPWEVGDVLQGIVVGEVVESEHDRFETGDLVTGEGAWAEHSLLDAHEVAPVDPRVADPPAYLGALGMPGRTAYFGLLEVGDPKPGDTVVVSGAAGAVGSVVGQIATLNGCHVVGFAGSDEKTDWLTEDLGFDAAINYEATDDYRAALEDAAPDGVDVYFDNVGGPITDAVFTKLNLDASVAVCGQIAHYNDEEVPMGPRKLPMLIAPRASVEGFLVGDFSGRFREASEQLAEWVASGQIEHRETVVEGLDRAPEAFLGLFAGENIGKQVVQVSGPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W285</accession>
    <name>R4W285_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_14110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14110"/>
    <dbReference type="EnsemblBacteria" id="AGN02761">
        <property type="protein sequence ID" value="AGN02761"/>
        <property type="gene ID" value="L593_14110"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14110"/>
    <dbReference type="eggNOG" id="arCOG09681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_21_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="263"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="546" mass="57352" checksum="0EA05C4C9DE5F37D" modified="2013-07-24" version="1">MVDSEASDMNGDPDGNGGEPPDPAALLDRAGLDVEGLARRKAAIGLDERDARRLSKLQPVLRERRAEIVERVSGSAEHGDEESDGAGASVTERIERTWRTELTGLGTGTYDESFARDRAAIALETTEADVPLSQYLAVHGRTYDRVFADLEARITHEIESAIESWAEDQSETDGGGGVLGGLKAAVGGNGDGTEDEAIEALESAITEAVADGLGDAGALARVGALDAGIAADVTTEHSERRAERARRRWASLLDALEDDVAVPLGNVHETASSVATSAATITELAGAQAEEVPAAAADLDDLTATIEEVAATAEEVRDASAETEERADAGLESAREAVEEMEAVRTATEGLVTVVEELEERAERIDAIAESIDDVASRSKVLASNAQAQANRDVDAKRSLQVLSEEVSAFADETRDELGDLPAEVTALQEVAEAVGREVERADDRVTDGADRVAAVEREIEAMATAAETTASHMDEVAAATDRQATAAESISGSVDRLARRSEQIAAETESVAAATEEHAAALGEVVDSLDRIRTEHAAARQSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W298</accession>
    <name>R4W298_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14210"/>
    <dbReference type="EnsemblBacteria" id="AGN02781">
        <property type="protein sequence ID" value="AGN02781"/>
        <property type="gene ID" value="L593_14210"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2907"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050975_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="26877" checksum="7C26A8F0B3BB3AE8" modified="2013-07-24" version="1">MFMLPPIAASWFGAVLGGLESVALGAVHSLAIFAAVYTAHVKDGYVDFHVRDEDDDHPLTVSGCRIALAGATAVFFSLLGVLWIGVNLVAALLTLPGWLIGYHHAPQLDTNPLTATTGYPAGIALAILGGSYVQAVSIGAVTAAFALVFLLVLSGVKVIDDAQDVAYDRSIDKRTVAVTVGPPAARRLAYGLMAVGLLVVVALVAVAVFPPTSVLAVAAFGAVVVATRRADAELATMLLVRGAYVFLAVLVAAVWFEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3S0</accession>
    <name>R4W3S0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="1">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrE</name>
        <name evidence="3" type="ORF">L593_03730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445591.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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        <property type="gene ID" value="L593_03730"/>
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    <dbReference type="GeneID" id="16180707"/>
    <dbReference type="KEGG" id="sali:L593_03730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.758"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_024853_0_0_2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:NADHX epimerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="YjeF_N_dom"/>
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        <property type="entry name" value="YjeF_N_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="yjeF_nterm"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="259" mass="26233" checksum="95BB6A3270518F1B" modified="2013-07-24" version="1">MIPDAFRTVDGRTVPAVTAAEMRDVDHVAVETIGVGVLQMMEHAGRGLALEALSLLDGDSVGGSGPRAPRHTAAPIPDEPVVVLAGAGGNGGGGLCAARHLANRGVPVRVVLDRDPGALDGPAATHLSILESMQIDVERGPDATATVAPSVILDALVGYGVDGALRGTSAALAGLANETSAPTLSLDVPSGLDATTGDRPGTVVDADAVLTLALPKTGLDADPAPVLADIGLPAAVYEALDIPYESPFDRRFRVRLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4W463</accession>
    <name>R4W463_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04940"/>
    <dbReference type="EnsemblBacteria" id="AGN00937">
        <property type="protein sequence ID" value="AGN00937"/>
        <property type="gene ID" value="L593_04940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04940"/>
    <dbReference type="HOGENOM" id="CLU_2893413_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6800" checksum="F71B92C9F4607AE2" modified="2013-07-24" version="1">MLKRPFRSVVPVDEMHLVTTLSQPLNDVSDVDCTSPHHRVAKGYGLFGEVEDAHASTPDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W469</accession>
    <name>R4W469_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L593_04990</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
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        <property type="protein sequence ID" value="AGN00947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445841.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00947">
        <property type="protein sequence ID" value="AGN00947"/>
        <property type="gene ID" value="L593_04990"/>
    </dbReference>
    <dbReference type="GeneID" id="16181166"/>
    <dbReference type="KEGG" id="sali:L593_04990"/>
    <dbReference type="eggNOG" id="arCOG02043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008803_0_0_2"/>
    <dbReference type="OrthoDB" id="5183at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041154">
        <property type="entry name" value="AglB_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026410">
        <property type="entry name" value="OlisacTrfase_arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18079">
        <property type="entry name" value="AglB_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04154">
        <property type="entry name" value="archaeo_STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="AglB_L1" evidence="18">
        <location>
            <begin position="804"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="885"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="916"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AGN00947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="989" mass="106776" checksum="E1926C6CDB14CBAD" modified="2013-07-24" version="1">MSTETEDDQLPESEAIVEPLQRWYHVPALAAILIYMLWTRTRAYDKFVRDGEVLFSGNDPYYHYRATMYSVKNWPSRVYGEPWTLFPEGQNVGNFGTLMDQVVATVALVAGLGDPSAQQVAKISLLAPAIFGALTTIPAYFLAKKLGGNRISGLTAAGLVALVPQASWITRTSVGYYDHHVAETLTMSIAMLAMVNALVVVGRERPVFEQVQDRDWDGLRPTLVASVLAGVALAAYLLTWAAGVVLVGIFGVFFVVAMSVAVIRGESPEHLAFAGVITHLVAFLVVLPFIQSFTIETTTLSLLQLLPIIGIVVGCTILAAIAREWENRELDPGLYPLIVAAIGLVAVGAIWVLLPEVAQAVWGNLQRILFLGQSDTTLTISEAQSMLADDRPPVTEQFWDGYGFAFFTAMIAGIWMVARGLLAKRTRSEYLLITVWTAFLLMMTLTQVRFHYYLVIPVAVLNGWLVAQVLRIAAFPSLEDFEDLQAYHVLTVFAILMLLFVPIASPIAAATAADLSSDTRPGSSVTTWDDSLDWMSENTPEPGTYGGEENEMNYYGPFDAVEGNYEYPAGAYGVMSWWDYGHWITVEGERIPNANPFQSGARGASAYFQATNETRANLMLEALSSSNVSGGQLDDMSNAELREAIEAQSEQEAGEDTRYVVIDDQMVGDKFYAITQWAGADFSDYYTGERYQLGGQNTTLTVPSETYRDTMLAELYFGDAAGLSHYRLVHEVDSYSVVGGYVSPNRAGPFTTLRYGFDWADAQQTAAQLRQASFFGQALQAGQNAYIYDASVESTVKTFERVEGATLTGQAEPNESVIVTVPVQTGTNRTFTYSQQTTADADGSFEITVPYPTNNELGPEDGYTNASAVANGTYTVRAGGFQNPRAQASDVSVPEPAIYDGSEIPVDLEPVEGGTGNDSTDGNASGSMSEASATSETSASGSAAEPETTSDVGSSAISTGAFGALAAPGNALTAPVRSLFESFAAEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4R2</accession>
    <name>R4W4R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446176.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06675"/>
    <dbReference type="EnsemblBacteria" id="AGN01282">
        <property type="protein sequence ID" value="AGN01282"/>
        <property type="gene ID" value="L593_06675"/>
    </dbReference>
    <dbReference type="GeneID" id="16181488"/>
    <dbReference type="KEGG" id="sali:L593_06675"/>
    <dbReference type="eggNOG" id="arCOG02272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099316_0_0_2"/>
    <dbReference type="OrthoDB" id="57581at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="26878" checksum="C7DDA8DB9F04C5E3" modified="2013-07-24" version="1">MIDLTMDMEQYDCPFIATTDDYEVSFAAVHWEFDEGARELETRLVVEGSSQPTLENGLDALQSHPGMNQCDLFRKRGDTAFIRTVIEETDAMGVIRANDGYITGPFRIAEGSETWEVGFDDKRIAGDALSELDRNNEFTVESRDVLALDDCFDLLENADAAAELLEGCRDLSDVERQTLSVAADSGYFEQPRDATLQTLADEFEVSDTAVSKNLRRGERKVLRRVVNALESLDSSPAGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W514</accession>
    <name>R4W514_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01457">
        <property type="protein sequence ID" value="AGN01457"/>
        <property type="gene ID" value="L593_07560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1549"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="555" mass="56753" checksum="A694FCD49DCF0856" modified="2013-07-24" version="1">MSDGDESSPAEPTGGTDGDDVIDAEETTNADEVTDAEPADRTGGDGATESEAADRTDADEQAERFTEGTLVWPLLTLAGPLVATQILQTLYNLADAFWVGQVSADAITAVSFAWPIVFLLISVGGGMTAAGTILVSQYTGARDDEAVGHVAGQTLGFVALLSLGISIVGIVSAPHLITLLGADPDGAVHAMATDYTRVTFLGLWAMFGFFVFQALLRGWGDTKTPMYLTIGSVGLNLVLDPFFILGFADNPLLLWVGLGGLGETLHAATGFSGWGVVGAAVATILSRGLAAAVGMWLLFGDHVGITVALSDLRPEFASVRKIVRVGAPISVEQSTQALAITIMTALLGLVSADAVGGFGIANRVTTLVWFPLVGMGMAVETVAGQNVGAGRPDRAKRVVLYASAILVAAFVVVGAVIAVYAAPITGLFVTGDDAAIVGHGADYLRWVAPTYAIMAIFHMINGGLHGAGATRLSMGLGLFALWGAQTVIAAVLIVWVGMGATGAWIGVAAANVIAALAGTAVFAWGGWLDSVVDADPEANADPEQAGTGATAEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W567</accession>
    <name>R4W567_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">L593_08010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446441.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08010"/>
    <dbReference type="EnsemblBacteria" id="AGN01547">
        <property type="protein sequence ID" value="AGN01547"/>
        <property type="gene ID" value="L593_08010"/>
    </dbReference>
    <dbReference type="GeneID" id="16181992"/>
    <dbReference type="KEGG" id="sali:L593_08010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1641"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OrthoDB" id="14061at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
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        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="313"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="517"/>
        </location>
    </feature>
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        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
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        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
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        </ligand>
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        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="AGN01547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="551" mass="60943" checksum="643FFE88C5776560" modified="2013-07-24" version="1">MPTESTTDYDPSLGNKFIFVTGGVMSGLGKGITAASTGRLLKNAGFDVTAVKVDPYLNVDAGTMNPFEHGEVYVLSDGGEVDLDLGNYERFLDEEMTSDHNVTTGKVYQHVVEAERAGDYLGKTVQIIPHVTDDIKRRIREAAEGTDVCIVEVGGTVGDIEGMQYLEALRQFAHEEDEEDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDVLVGRCEDRLEEETREKIALFCDVPTDAVFSNPDVEDIYEVPLMVEEEGLDEYVMERLGLAEAALPPGQRENEWRNLVTREKSGEIEVALVGKYGLEDAYISIHEALKHAGMEAGVEVNRTWIHSESLADGVTDELDDVDGIIVPGGFGSRGTQGKINAVRYARENDVPYLGLCLGFQMAVIEAARNLAGLKGAHSTEIDENTDHPVIDILPEQYEVEDMGGTMRLGAHDTDIEPGSLAHQIYGTTSCTERHRHRYEVNPEYIDRIEETGLKFSGRSANRMEIVELEDHPYFLGTQFHPEFRSRPGRASPPFVGLVEAIVEQADEEIGTKEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5B8</accession>
    <name>R4W5B8_9EURY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08435</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN01632">
        <property type="protein sequence ID" value="AGN01632"/>
        <property type="gene ID" value="L593_08435"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01369">
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="35715" checksum="AF712F984EB9CA2B" modified="2013-07-24" version="1">MEYFVTGGTGFLGGHVTQQLVADGHDVVALARSPADADDLRDLGVDVVQGDVTDRETLREPMSGVDGVFHVAAMYRLGVDDPATMRDVNVEGTRNVLDLVAALDLPKAVYTSTLAVNSDTNGELVDESYRFEGTHLSAYDRTKAEAHDVAMALAADGVPIVTVMPGAIYGPGDTSQLGGIWRDYLRGEFPAVPRRTAWCFSHVDDAARAHLLAMERGEPDEAYIVAGHPMTLVEVLSVAEELTGIPAPRSVSPAWFRLASRLAGLLERAVTLPPDYRAEPLRVLGGATYLGDDRKAREELGVEHRSFEAGFAEALDAMAREEEVDVTVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5G8</accession>
    <name>R4W5G8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_08785</name>
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_08785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1800"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="103678at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
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    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13170" checksum="CF949431B27CF464" modified="2013-07-24" version="1">MKQIIDTNAAPEAVGAYSQGASNGDLVFTAGQIPLTPDGRLLDDASIAEQTEQALDNLVAVLAEGGAEPADVLKVTVYLDDIEDFEEMNETYAGYFEQEPPARSAVGVESLPKGAGVEIEAIAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5J9</accession>
    <name>R4W5J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446661.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09110"/>
    <dbReference type="EnsemblBacteria" id="AGN01767">
        <property type="protein sequence ID" value="AGN01767"/>
        <property type="gene ID" value="L593_09110"/>
    </dbReference>
    <dbReference type="GeneID" id="16182623"/>
    <dbReference type="KEGG" id="sali:L593_09110"/>
    <dbReference type="eggNOG" id="arCOG01902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105248_0_0_2"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="76"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="27273" checksum="18A1A01DEC6AD437" modified="2013-07-24" version="1">MDSRTIGVQSVVFGDRKLSAVLDELDDADVDVLELWGDHLSPNDHGATVAASVAALKATMVDVRGYGVVDVEEPEDVEDHVAFADRLEADYVTVNYPPMRDDVTAELLEQAEAYDVDVAIHNYSSVHHDDTSQVFSSLAEVQDVLERNPHDRLGACVDTGHFLVEDVDPADVIESLGDRIVTVHLKDTSEAAIEDVPGAGELELETVLDLLDAHADPDVPLIVEYELDPEEAVADLREAVANVERALASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Z4</accession>
    <name>R4W5Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00590"/>
    <dbReference type="EnsemblBacteria" id="AGN00073">
        <property type="protein sequence ID" value="AGN00073"/>
        <property type="gene ID" value="L593_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00590"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.120"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="36396" checksum="FA14F8C1309D30C5" modified="2013-07-24" version="1">MATEHSTERSTERATEPSAEHSFEDRREQTVDWEKLKAIVVFMVPGLTLFAIFSVGPMVYSAFGSFYAWDAFDLQHFVGLETWVETFQNDAIINWDNLTSLEYPMGALPQNLIWMVVHVPLSTFLGLGLALLFADLRGRRILRSMVFLAFTTPTVVIGLVLLFVYDPQAGIFNAFLSSVGLEGQVRNWLQEPQIAIYALIAGGVWVQTGFSMLLYSSALAGIDPSLLESARIDGAGRYRRFRDVIWPLVKPVTAVVVIMGMIWVLRIFAIVYAAGGPSGGPNGVYSVLGLEVYQSAFSIPIRYGEAMVVALIELFIALPMAWYIASMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W640</accession>
    <name>R4W640_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PHB synthase subunit PhaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00965"/>
    <dbReference type="EnsemblBacteria" id="AGN00148">
        <property type="protein sequence ID" value="AGN00148"/>
        <property type="gene ID" value="L593_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.198"/>
    <dbReference type="eggNOG" id="arCOG06344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035017_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010125">
        <property type="entry name" value="PHA_synth_III_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01836">
        <property type="entry name" value="PHA_synth_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="74"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="484" mass="53373" checksum="83214A382BB5F20F" modified="2013-07-24" version="1">MTTMQNPYAGFLDMQRTAWEQATEAAEKLGAAPDANESIASVDVGETPSEVVYEENKLRLLHYEPLTEEQHDVPILIVYALINRPYILDLQPSRSVVRTLLENGFDVYLIDWGEPSILDTSLTLEDYVTRYIDNCVDEVRDRSGQDSINILGYCMGGTMSSMYATLEPEKVRNLGLMAAGLCFAGEGGILELWGDEEYFDPDAVTETFGNVPAEFLDTGFALMDPVENYVTKYVRFYENMEDEDFVENFARMEEWLGDGIDVAGAAFDEFIEDIYQENKLYENELYLGDRHVDVNEIDMPVLQIVAEYDHLIPPGASKPFNDVVGTDDVTTMEFATGHIGMSVSSRSHAQLWPDVCEWFEERSQLEDDEPATESAAEPEPDTESAAEADDEASASETSISEAEGADEAATEDAETGESEAETADAATLQDVDGIGPAYEERLEEAGISTVAALADADAAALAADTEVAPNRILSWIEQAEQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S3</accession>
    <name>R4W6S3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02492">
        <property type="protein sequence ID" value="AGN02492"/>
        <property type="gene ID" value="L593_12765"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12765"/>
    <dbReference type="eggNOG" id="arCOG04799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117487_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043870">
        <property type="entry name" value="DUF5830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19148">
        <property type="entry name" value="DUF5830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="160" mass="17146" checksum="BD40FAFEF4AEF3C4" modified="2013-07-24" version="1">MVGNRDGTDEPDGIGAPDRVGNSNRAGDPDRAGNPSRAGGPDDAADPVELGVALLKRLEHAELSVADAMDRIELVTTDPALQRQILREAEDRGAIERDDDVVRPAGDAFVRFESEVVVREGEFDCQRCGASITEGHFIKLEDSEIGAFGSSCVRKVTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X3</accession>
    <name>R4W6X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type ATPase, translocating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_13165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447466.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13165"/>
    <dbReference type="EnsemblBacteria" id="AGN02572">
        <property type="protein sequence ID" value="AGN02572"/>
        <property type="gene ID" value="L593_13165"/>
    </dbReference>
    <dbReference type="GeneID" id="16182407"/>
    <dbReference type="KEGG" id="sali:L593_13165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2694"/>
    <dbReference type="eggNOG" id="arCOG01578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_2"/>
    <dbReference type="OrthoDB" id="17967at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="901" mass="94807" checksum="31DAB01D81EB2D54" modified="2013-07-24" version="1">MDWHASPPEECTDELDSSPEGLSEADAAERRERVGPNELTSGEVRGPLRIFLSQFASALIWVLILAAVLSVAIGHVVDAVLIAIILLANGIFGFVQEYRAEQSLEALQDLASPTVTVRRGGAETRIAATEVVPGDVVVLGQGDVVPADCRILEAGSLEVDEAALTGESVPVEKSADPVDADAPLAERSSMCYKGTNVTRGSATAVVVATGMETQVGEIATSLEQAENRQTPLQQDLDRLGKRLGLAVVALSATIVPLLVLGGGRSLVQSALTAVSLAVAAVPEGLPAVVTLTLALGVRKMAGEEALVRTLPAVEALGAIDVVCTDKTGTLTEGEMRVQAAWVFDEAYETVDSGDESVATNGDGAAGTTAEAAGSLAHGGDERLDRLLEIGAVCNDATEEDGDPTERALVAAAERRFDVDELRAERPRRDELPFSSERKLMATIHDDAVFVKGAPTVVLDASTRVLGPDGPEPLDDERRERIRDQIDAFAEDALRVLGFAYRDPPDAAVDAATSDGAEAMADLESDLVFVGLQGLLDPPRPEVADAIADTQRAGIDVKVITGDNPTTARAIASQIGVDSDVVSGTEIESMDEAELRECVQTTDVFARAEPTHKVRILQALQAEGHRVAMTGDGVNDAPALKNADVGIAMGVRGTEVAKQASDVVLLDDNYATIRNAIRRGRTIFDNVWKFVAYLLSANVAEVAVVLIASLFGYLVLPAVQLLWINLLTDGLPALALGVDPGGDVMERQPRERIRGIIDGPMLELIGGAGAIATALMLGLLAVTLDGASSMTDYAMTMVFTGFVVLEFVKLYVVRWARDTPTLSNPYLGLAVGTSLVLQLAILYTPLSTYFGTVALDAGDWALLGVVLLVGTPAMLAVAWHSRRSATAEDADASDEPTPAIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W743</accession>
    <name>R4W743_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase/Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02687">
        <property type="protein sequence ID" value="AGN02687"/>
        <property type="gene ID" value="L593_13740"/>
    </dbReference>
    <dbReference type="GeneID" id="16182721"/>
    <dbReference type="KEGG" id="sali:L593_13740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2810"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="41173at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="28754" checksum="4781ADA1BC181201" modified="2013-07-24" version="1">MTGQLDHVMMRVEDLEAAEDFYKGHFGYEEVGRWDADTFTNVHLAPPDASDDAATLELTYNHDGRSYTMGDAWGHIAVRVEDVYEAYDELMEAGVEDYRDPDSCGGSYAFVKDPDGHEIEIVERDHGARWSLDHTMIRVEDANEAIGWYQRAMDYDLVRRAEMDSFALYFMAPSDAPAEAMTVELTYNYDGRSYELGDAWGHLAARVDDLEADWDTLMLRDAEDYRDPESCDFNYAFTKDSDGHEIELVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W787</accession>
    <name>R4W787_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13990"/>
    <dbReference type="EnsemblBacteria" id="AGN02737">
        <property type="protein sequence ID" value="AGN02737"/>
        <property type="gene ID" value="L593_13990"/>
    </dbReference>
    <dbReference type="GeneID" id="16180998"/>
    <dbReference type="KEGG" id="sali:L593_13990"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102056_1_0_2"/>
    <dbReference type="OrthoDB" id="76153at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="224" mass="23831" checksum="26F4DFD1EE1B1F5C" modified="2013-07-24" version="1">MEPSTSNGRGSLSAAVDAPSFLLVELPRFDERDTSACLDLLTASEPAGEKLLIVSVTETIGKTHRRWDDHVGEHPDEFAVVSASFAESAPGEDAPDEAGGTTPAAADGPEPTASSWLTTHQVDDPGDLTGLGITVSNQLAEWADAEEQVVVCFRSLTTTHQYVGTQELVRFLGELRKHVEASDAIAHFHLDPDAVDTQTRAAIRSVFDGVVVASDDDPGVELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W795</accession>
    <name>R4W795_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445732.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04435"/>
    <dbReference type="EnsemblBacteria" id="AGN00838">
        <property type="protein sequence ID" value="AGN00838"/>
        <property type="gene ID" value="L593_04435"/>
    </dbReference>
    <dbReference type="GeneID" id="16180918"/>
    <dbReference type="KEGG" id="sali:L593_04435"/>
    <dbReference type="eggNOG" id="arCOG03915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159082_3_0_2"/>
    <dbReference type="OrthoDB" id="115004at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="99" mass="10509" checksum="AD02329CF4FD1D74" modified="2013-07-24" version="1">MHIELVIAKLVTVGLGLLITFQAYKGYRAYGNEPMLYLAIGFLFISVGAVIEGVLFDVVGLSIFLAGTIQTTLVGFGMIVILYSLYGRMPTSASGGNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G0</accession>
    <name>R4W7G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445842.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04995"/>
    <dbReference type="EnsemblBacteria" id="AGN00948">
        <property type="protein sequence ID" value="AGN00948"/>
        <property type="gene ID" value="L593_04995"/>
    </dbReference>
    <dbReference type="GeneID" id="16181167"/>
    <dbReference type="KEGG" id="sali:L593_04995"/>
    <dbReference type="eggNOG" id="arCOG04565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="310" mass="31711" checksum="E32B193088A55A4E" modified="2013-07-24" version="1">MQLRAAIVTFLKGAAMGTADIVPGVSGGTIALIAGIYDRLVGAIAELHPSPLLHLLRPYDAAERAAFAEAWQEMDITFLLVLGSGMVTAVIVLSQLIPIALEEYRALTGAFFVGLIAASVVLIGRDVPWTRVRTALALGAVALVVLVATITVNLADPSIAFVFAAGAIAISAMLLPGLSGALLLLILGQYEYLLDQLDALLSALAGVATGSDSIADVVEPGAVVVAFLSGAVLGVLTLGRVVDRALERDRATTIAVLVGLMAGGLYPPGRMAVNSATGSLTQAAAAVVIAVVGAVVVTAFDYVTHDLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J4</accession>
    <name>R4W7J4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps4p</name>
        <name evidence="4" type="synonym">rps4</name>
        <name evidence="8" type="ORF">L593_05245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="4">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445892.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05245"/>
    <dbReference type="EnsemblBacteria" id="AGN00998">
        <property type="protein sequence ID" value="AGN00998"/>
        <property type="gene ID" value="L593_05245"/>
    </dbReference>
    <dbReference type="GeneID" id="16181175"/>
    <dbReference type="KEGG" id="sali:L593_05245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1071"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OrthoDB" id="93256at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="6">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="19692" checksum="D3D7EA0C84D77604" modified="2013-07-24" version="1">MPLGSSTKQYETPNHPWQGERIAGEHNLVERYGLANKEELWRAQSELRDLRREARELLGRAGGDADAATQEGAEFLARLKRYGVLDESEALDDVLSLEITDVLERRLQTVAYRKGLANTPQQARQFIVHGHVTIDGQRVQRPSYTVEVDEAADIEFDESSPLADELHPERAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q4</accession>
    <name>R4W7Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444858.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00045"/>
    <dbReference type="EnsemblBacteria" id="AGM99963">
        <property type="protein sequence ID" value="AGM99963"/>
        <property type="gene ID" value="L593_00045"/>
    </dbReference>
    <dbReference type="GeneID" id="16181792"/>
    <dbReference type="KEGG" id="sali:L593_00045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.9"/>
    <dbReference type="eggNOG" id="arCOG00610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514568_0_0_2"/>
    <dbReference type="OrthoDB" id="74833at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="19160" checksum="A4F450B780E3A9E1" modified="2013-07-24" version="1">MSSIELTPSQKTILTALVNLYGEESENAVKGEQIAEEVDRNPGTIRNQMQSLKALQLVEGVPGPKGGYKPTPTAYEALDVQQMDDAASVPLFHEGELLEGATVEEIDLNSIHHPDLCRAEIHLQGSIRSVEEGDQVTVGPTPLSKLQVTGTVDGKDDTANVLILQIEDMKAPAEEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z1</accession>
    <name>R4W7Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="188" mass="19276" checksum="C5BA837BCEC616E1" modified="2013-07-24" version="1">MAGGSALVASLAGCSGGGGDDDPSSRGPVSIDELAFAAGRPDGYAAYEPQPDSVYGPNDVVWVYLAVSDVSGEPVVESDAANQSEQTGDESSSAGGDDGGSAGEEETIVDVDLRQRLRVEAPDGSLVAESTDEFQPTLSVRQLDSFFVATDVLHAGTPTPGEHETTVTLTDRVSETEATESATFSIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z8</accession>
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            <fullName evidence="3">Putative sulfatase</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_07055</name>
    </gene>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN01358">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="41812" checksum="974544EA20CE2A7C" modified="2013-07-24" version="1">MRDVILVSADSVRHDFLDAMPYVSSTLTNHETITGAHYTRPSLASLLTSNYQGAVESRVVEPSVAEAFSDAGYTTIGLSSSPHTDARFGFDQGFDVYHHFSEAGNRGNPIRQFASQFDLIRKVYHRFKPPHAKLSNRLPDDELIDESIEAFNAEDGPRFMWLHLMGTHRPYGLGDDAVPKDVDRKALFKPEKLTDAERETIEEKYRATLQRADAEIERLVESVDAEDPIVVFTSDHGDEFGEEGVWFHQPQRGRVADALITVPAATNDLDLEAPLSSLDIAPSILADQAGPDAIPPEWHGKDVRPEANGGQGARNHTLTVAPWHGSATLAWQDFETKVVAQHADLELSRDGETIEAERSDVDEDLKQQMRDLGYVE</sequence>
</entry>
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    <accession>R4W863</accession>
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        <submittedName>
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    </gene>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CSD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="7075" checksum="778D80A89EC44969" modified="2013-07-24" version="1">MANGKVDFFNDTGGYGFIETDDADDDVFFHMEDVGGEDLTEGTELEFDIEQAPKGPRATNVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A7</accession>
    <name>R4W8A7_9EURY</name>
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    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01618">
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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    </dbReference>
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        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="34003" checksum="B45F676F3761EEF6" modified="2013-07-24" version="1">MASIPRRSLLVAIAIVPIAFLAILGGTNVVALDDDGAPAAAEVWGGSDPFVTDTDGDGLDDATEYDIGTDPRVADTDGDGVEDGRERQLGTDPTRADTDDDGLPDGSEVAIGTDPFLADTDGDGLPDGAEVDGATRDGVSLPDADPLRMTLYVRIDHAEGAAPVSAADAERLAAHFAAMPIENPDGSTGVDLQVQRGDRLKVGPYTGENFDALAAASERVRGDRSRVARGILVVPFESDLASVGYGRTPGRFLVVDAGASADDRESIAVHELLHNVLGELDASPGRCEADPAHYCDGGWLEPSLGDGFERTLPQPVAEQVEDDGFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D1</accession>
    <name>R4W8D1_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_08640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446567.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08640"/>
    <dbReference type="EnsemblBacteria" id="AGN01673">
        <property type="protein sequence ID" value="AGN01673"/>
        <property type="gene ID" value="L593_08640"/>
    </dbReference>
    <dbReference type="GeneID" id="16182494"/>
    <dbReference type="KEGG" id="sali:L593_08640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1771"/>
    <dbReference type="eggNOG" id="arCOG04719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710987_0_0_2"/>
    <dbReference type="OrthoDB" id="79206at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="43734" checksum="57F54337814FB0CB" modified="2013-07-24" version="1">MSERDHPGDAGTTGTVERPTVSDDALAELEAAAEDYRAAKAAIEDVGRDTLETLDDRYRTANDLLVEFQDKATDTGAKEFVQFATFKQRFTDHVEGLDDDLPRREAFEHALEAVDKTRLSEDDFQRALDALEPAAALAERLDDETAARDRLVAAITDARKAKQSHQDSIDRCERLLELGEADLDAPVEDLRDPIETWNDAVSEAIRIQRTDAPARELFDLLERTGRYPLVDLDAPPEPLAEYVQTNPPGEEPVARLLEYADFSRSKLDHYVEDPGAFRRAVATERTYLERLDADGLTVGWPPPPADEVPWLVRELQGAAAGLVDEEANAALRSVAEMAREGDEYERLRTAAVARHQLDEEARERLRSGAVEAELTEHEAAVEALQTALADAPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E2</accession>
    <name>R4W8E2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusG</name>
        <name evidence="3" type="synonym">spt5</name>
        <name evidence="6" type="ORF">L593_03140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445473.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03140"/>
    <dbReference type="EnsemblBacteria" id="AGN00579">
        <property type="protein sequence ID" value="AGN00579"/>
        <property type="gene ID" value="L593_03140"/>
    </dbReference>
    <dbReference type="GeneID" id="16180451"/>
    <dbReference type="KEGG" id="sali:L593_03140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.635"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OrthoDB" id="91936at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16383" checksum="11BDA8F172A8E4C5" modified="2013-07-24" version="1">MPIFHVKTTASQEQTVADMIVNREEETIHAVLAPDSVTSYVMVEADSAAVFERILDEIPHARGVVQRDGEAAGSGFSEVEHFLSPKPDVEGIAEGDIVELVAGPFKGEKAQVQRLDEGKDQVTVELYEATVPIPVTVRGDQIRVLDSEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E6</accession>
    <name>R4W8E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445488.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03215"/>
    <dbReference type="EnsemblBacteria" id="AGN00594">
        <property type="protein sequence ID" value="AGN00594"/>
        <property type="gene ID" value="L593_03215"/>
    </dbReference>
    <dbReference type="GeneID" id="16180158"/>
    <dbReference type="KEGG" id="sali:L593_03215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.650"/>
    <dbReference type="eggNOG" id="arCOG00352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_0_0_2"/>
    <dbReference type="OrthoDB" id="66209at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOG1_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="NOG1_N" evidence="3">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="NOG1" evidence="2">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="37075" checksum="D50F998008D2428C" modified="2013-07-24" version="1">MIFEGLPGTPTAEELEDQAFSRAARAGRAKSGVDAQLSMLQTAANVIGDNLENVVKGWPDFELMDPFYYELADAVLAGEGVVRRTRDGEGNVEETTGIDALRQALSQVSWASRKATELRDEYQPRVHGGGNTARKHRKQAFARLADVVEQVDDDLTLIRDAREHLRTLPELNPEEPAIVVAGYPNVGKSSFVNAVTRARNETAAYPFTTTGIGVGHFERDHVRYQLVDTPGLLDRPAEERNEIETQAVSALEHLADCVLVFLDASEAAGYPIEDQVALYEDVAEEFEVPVVSVCNKSDLSTDVEADHYVSVTGDEGLDELLDDAVERIGFEPELPYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G4</accession>
    <name>R4W8G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446642.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09015"/>
    <dbReference type="EnsemblBacteria" id="AGN01748">
        <property type="protein sequence ID" value="AGN01748"/>
        <property type="gene ID" value="L593_09015"/>
    </dbReference>
    <dbReference type="GeneID" id="16182710"/>
    <dbReference type="KEGG" id="sali:L593_09015"/>
    <dbReference type="eggNOG" id="arCOG07866">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122604_0_0_2"/>
    <dbReference type="OrthoDB" id="99334at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="25188" checksum="D3C17A439CCF97F5" modified="2013-07-24" version="1">MQPTTAAVVKATGGAGATRTSLELAATLGRAGHAVGVLDVDFATQGLAAHVPGRIEADLTNVLVEDGSLGDASVDLDLDPLRDAGGRVAVAPSRAPFERLARAKTPRAAQTFETVLDDAAAQFDYVLVDAPPVATNPAVSAVTTADRVAAVTPASQRGVDALQRLRERLEDVGAAPGLAIANRADGEHPVQAADAALPTHEVPEAAVPSAADPDPAYAPAVAEAAEALFDVELALEFPEEGLIAGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G6</accession>
    <name>R4W8G6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">L593_09040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446647.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09040"/>
    <dbReference type="EnsemblBacteria" id="AGN01753">
        <property type="protein sequence ID" value="AGN01753"/>
        <property type="gene ID" value="L593_09040"/>
    </dbReference>
    <dbReference type="GeneID" id="16182573"/>
    <dbReference type="KEGG" id="sali:L593_09040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1854"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_0_2"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="34864" checksum="0880C0AD4887955A" modified="2013-07-24" version="1">MTADTPNDGSNDPSTGEPFRGVYPAMLTPFDDTGSIDYEQLRAEARRLEAAGVDGLVPVGSTGESATLSHQEHVDVVEAVVDAVDEVPVVAGTGSNNTREALELSHAAKDVGADALLLISPYYNKPEQRGLEAHFREIADTVDLPQIVYNVPSRTGRNVEPDTVVALADHPNVAGYKAASGDLGQVTEVVERTREYDFSVLSGDDALTLPMLSVGATGTISVAANVEPERTVAMVHSALEGDYAAARTLHHELGPLFRELFVETNPIPVKEAAAMRGYCGPTIRPPLSRLAEEHREPLQDLLDELEATREEALAGVAAAPAISAGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I0</accession>
    <name>R4W8I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01798">
        <property type="protein sequence ID" value="AGN01798"/>
        <property type="gene ID" value="L593_09265"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09265"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="103" mass="12008" checksum="7A275F63A332F675" modified="2013-07-24" version="1">MIIASLLEEPKERRLPLPDAAESPNQPMDSETLRIKLRHHHLPLLARAGYVQWEEDPFVVQRGPRFEEPATIIRMVTESVDDLPRPLIDNCKIFQEWVENGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R1</accession>
    <name>R4W8R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPE repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445743.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00849">
        <property type="protein sequence ID" value="AGN00849"/>
        <property type="gene ID" value="L593_04490"/>
    </dbReference>
    <dbReference type="GeneID" id="16180967"/>
    <dbReference type="KEGG" id="sali:L593_04490"/>
    <dbReference type="eggNOG" id="arCOG14593">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152682_0_0_2"/>
    <dbReference type="OrthoDB" id="130765at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="10751" checksum="0E62A61557A4466E" modified="2013-07-24" version="1">MELELEDVTGTVVVGLLLVALGLTVAGVETVAGFDVLAAGESAVGYLAAGNFSVGVLSTGIFSVGVFAAGIFSVGIFAIGIFSIGIFSFGIYAAGFYAAQRHIQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S4</accession>
    <name>R4W8S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase subunit DhaL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10515"/>
    <dbReference type="EnsemblBacteria" id="AGN02048">
        <property type="protein sequence ID" value="AGN02048"/>
        <property type="gene ID" value="L593_10515"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2168"/>
    <dbReference type="eggNOG" id="arCOG08942">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066424_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="27177" checksum="87A803A1C172B656" modified="2013-07-24" version="1">MTDEIDQGAAVEAAVQAVADRLADEKRYLTDLDSAIGDADHGANMNRGMQAAVEAVADADEDDPATLVQLVGRTIVSEVGGAAGPLYGGSAMIASKELADGITAESTVAFGEAFLEKVQDRGGANVGDKTMVDALTPAVHTYKKSIEQDDLPPLAALAKAVDAAHRGVDYTVPIRASKGRASYLGWRSVGHQDPGATSTLYILEALLGVAEEHLEGPVEEDATSPRVPDEEPAGDGPAAGGENGPPEGGENGGPSSEADDSEADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V1</accession>
    <name>R4W8V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445848.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05025"/>
    <dbReference type="EnsemblBacteria" id="AGN00954">
        <property type="protein sequence ID" value="AGN00954"/>
        <property type="gene ID" value="L593_05025"/>
    </dbReference>
    <dbReference type="GeneID" id="16181170"/>
    <dbReference type="KEGG" id="sali:L593_05025"/>
    <dbReference type="eggNOG" id="arCOG04784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433758_0_0_2"/>
    <dbReference type="OrthoDB" id="110906at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="10096" checksum="8CCE36455696A4FE" modified="2013-07-24" version="1">MKRLIVNGDPGFRKDAEITVDGEELVAFQVTRNGDWHGPDRVQLWCVVGTEDERQTYVERDFVPHWLDVERVEDSAVEVRTKGGDLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y1</accession>
    <name>R4W8Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lrp-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445928.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05425"/>
    <dbReference type="EnsemblBacteria" id="AGN01034">
        <property type="protein sequence ID" value="AGN01034"/>
        <property type="gene ID" value="L593_05425"/>
    </dbReference>
    <dbReference type="GeneID" id="16181354"/>
    <dbReference type="KEGG" id="sali:L593_05425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1108"/>
    <dbReference type="eggNOG" id="arCOG01584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088218_0_0_2"/>
    <dbReference type="OrthoDB" id="61698at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="27740" checksum="EB9D9865B1F54813" modified="2013-07-24" version="1">MSLEIDSIDERILYYLAQEARHTSAPDIAENVDVSPPTVRNRIRRLEEEGVIRGYHANIDYQKVGGRLTNHYVCSTGNRDRQEMAQRVLDIPGVINVREIMSGKGDLRISVVGSDTQDLTRIAQDITALDIEIDDEDLVHREYLRPFAPFGPRDADLVSPVTGVAGLAGDADVVEVLVRESAPIAGRTLQEANERDIVPPDVLVVRINRDDDSITPTGETAIREGDFVTIHSRTGVTDATLEAFTGHSSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W903</accession>
    <name>R4W903_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02228">
        <property type="protein sequence ID" value="AGN02228"/>
        <property type="gene ID" value="L593_11415"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11415"/>
    <dbReference type="eggNOG" id="arCOG08980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159738_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8452" checksum="FC06454E6E135D07" modified="2013-07-24" version="1">MGDNGATPASVRVVRSLADAQGMDPSELTFRLGDVIDTDALDAMAAHDGNGWELSFEVEDHEVRVVPGEPIVVDGTEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W907</accession>
    <name>R4W907_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02238">
        <property type="protein sequence ID" value="AGN02238"/>
        <property type="gene ID" value="L593_11475"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2366"/>
    <dbReference type="eggNOG" id="arCOG05861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779919_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="37757" checksum="449DD1AB8F6153EE" modified="2013-07-24" version="1">MTQDGPELTRRKLLGGLTAVGALGGGAGAITAATQRDDATVGDVITAGAPGIEIECLEADCSVTDGTLSFSVDGLVPGSSGERTVRLRTVDNALRVWVWTACPAADDELADALLVRLSIDRGCDGTPRQLFPESLGESWGTLRALQTAFADGRRLDDPQDPCLSPGSDTCLRLDYRLPEGARPEPGADSTVDLECYAEQCRHVSESSVRNPYEDVACEPAPCPACVHLGRLEVEGDRLEPGTYEFDELAERFRDDGHAYELDVRDVTTKDGGEPVCVDLALRRDDAPDARLCEVQLKGGTDVWTYGIEPARARTAEPVCTGPIESGANDRERRPAISYVDASVCVDDAGDGGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W978</accession>
    <name>R4W978_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Initiation factor 2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447352.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12595"/>
    <dbReference type="EnsemblBacteria" id="AGN02458">
        <property type="protein sequence ID" value="AGN02458"/>
        <property type="gene ID" value="L593_12595"/>
    </dbReference>
    <dbReference type="GeneID" id="16181865"/>
    <dbReference type="KEGG" id="sali:L593_12595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2585"/>
    <dbReference type="eggNOG" id="arCOG01124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_2_2"/>
    <dbReference type="OrthoDB" id="54988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="29996" checksum="58E15887FE835A05" modified="2013-07-24" version="1">MIDETAAEIEAMRTHSSSEVAIKAARALTELADREYATVEEFERDLERNAGALRRANPSHASLATVLDEIESAVDDGAFETVDAAQDGLEAAVDATIGVVEVAKDEASATAAQLLSDGDVVLTHDYSSTVIGAIERATSAGAELDVYVTEARPRFLGRRTARRLAEIDGVDPTLVVDSAAGHVLQSVDRVLTGMTCVVGDTLYNRVGTYPLAATAQDVGVPVTVTGSSAKIVDSGFVFENDFRDPVEVLREPAEGFDIENPAYDATPLELIDQLATDRGVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W983</accession>
    <name>R4W983_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447362.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12645"/>
    <dbReference type="EnsemblBacteria" id="AGN02468">
        <property type="protein sequence ID" value="AGN02468"/>
        <property type="gene ID" value="L593_12645"/>
    </dbReference>
    <dbReference type="GeneID" id="16180102"/>
    <dbReference type="KEGG" id="sali:L593_12645"/>
    <dbReference type="eggNOG" id="arCOG01900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080433_0_0_2"/>
    <dbReference type="OrthoDB" id="134892at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="278" mass="30597" checksum="E7A93753230BC92A" modified="2013-07-24" version="1">MHLGGPVHDEFDTPAAWIDALDERGYTAATAPVDPDADPRTIEAFVDAADEAGVVIAEVGAWEHNPIADDPDEREAAIDACARHLQLADEIGANCCVNVAGSRGNGWAAPHPENFTEETFERVVASVQEIIDRVDPETAEYALEPMPWIFPHDVESHHRLLEAVDRDAYGVHFDPVNMLSSPERVARNADFVERFVDELGEEISTVHLKDVVLRDELTTHVDEVRPGAGTLDYHALLSALDALDDDLPLLLEHLDDPEEYERAANYVREVAADVGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B9</accession>
    <name>R4W9B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447437.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13020"/>
    <dbReference type="EnsemblBacteria" id="AGN02543">
        <property type="protein sequence ID" value="AGN02543"/>
        <property type="gene ID" value="L593_13020"/>
    </dbReference>
    <dbReference type="GeneID" id="16180339"/>
    <dbReference type="KEGG" id="sali:L593_13020"/>
    <dbReference type="eggNOG" id="arCOG09235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061324_1_0_2"/>
    <dbReference type="OrthoDB" id="89485at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="26253" checksum="56581AA2905A5F5E" modified="2013-07-24" version="1">MGPPETAQEDDPAVTGSGEESREATSLEDLSFVGASTAATLSAADISVEDVDEKTVSYRELVEAGVNPGVAGKIRREHSLHWTHDEEAFDLDRRSKNVRGLREGEREWVASTEGTELEVSTDRPASQNDDSDGSQDVDGWYDGNGDRIGTNEVTGTAMDGDAADDELAGDGEDPFSAEAAWRERASSPSVATVGPVPADAAEALETVGVETVRQLATANVDRLATELGLDRDDLDYWQALAAQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D7</accession>
    <name>R4W9D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446308.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07345"/>
    <dbReference type="EnsemblBacteria" id="AGN01414">
        <property type="protein sequence ID" value="AGN01414"/>
        <property type="gene ID" value="L593_07345"/>
    </dbReference>
    <dbReference type="GeneID" id="16182824"/>
    <dbReference type="KEGG" id="sali:L593_07345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1500"/>
    <dbReference type="eggNOG" id="arCOG04634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_2_2"/>
    <dbReference type="OrthoDB" id="7579at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="695"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="778" mass="82754" checksum="03AF96687DB30A4F" modified="2013-07-24" version="1">MADTASTADEFDGAARSERVAALLEELTVGEKRVLVKGGIDPEGIATGYVPPIERLGIPDCSLVDGPMGIRAVTSTAFPATVSLAASWDPDLAERFGETIGREARGADQDVLLAPGVNIARVPQCGRNFEYYSEDPELTSALSTPMIEGVQSAGVMACVKHYAANNQETDRHEVSAEIPERALRELYLPAFEAAVTDAEVASVMAAYNRVNGTHATEHPRLLTGILREEWGFSGFTVSDWWATTDGPAAVEAGLDLDMPGMPVYEWHEPDVKLLDVLDALPDGAWFPKQRIAELLTEPWQPENSNPHVLEESHFGSELTAAIEDGRVSEADLDQMVERILGQYERFGLLDAAAADQAGTGSSDANDADPRPPGVIDADEHRDLAIEIAERGIVLLENAGVLPLDAEDLDSVALIGPHADEAKVGGGGSSEVDAVGTVTPPRGLRECLGDGVDVTVERGVDRIEMDAFTESPFPDLPSFEATGPSLADAERAASEANVAVVMVQDAATEGADRAFGLPGEQDELIERVAAAAERTVVVLKTSGAVAMPWREHVDAIVEAWYPGQADGGAVANVLCGNVDPSGRLPVTFGAATEDYPANTEERYPGRDLTVEYSEGVFVGYRHFDDADVEPLYPFGHGESYAEFEYGDVTASLDGSTIAEADASADDASPNDASAADGSIATVSATVENVADRGGWEVVQCYLSPPGDAIDRPPRELVAFESVPLDAGESRTVELPVDRRAFAYYDEDAAEWAIEDGEHTLSVGRSSRDRRASATVTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E9</accession>
    <name>R4W9E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447502.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13345"/>
    <dbReference type="EnsemblBacteria" id="AGN02608">
        <property type="protein sequence ID" value="AGN02608"/>
        <property type="gene ID" value="L593_13345"/>
    </dbReference>
    <dbReference type="GeneID" id="16182435"/>
    <dbReference type="KEGG" id="sali:L593_13345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2730"/>
    <dbReference type="eggNOG" id="arCOG04560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_2"/>
    <dbReference type="OrthoDB" id="110353at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12722" checksum="A2C49E7ED13FFED0" modified="2013-07-24" version="1">MSTDAATGGRVDVTDDAVEQALSLLNSEEMDPDESGLRLFVQQGGCAGLSYGMRFEDEPDEDDHVTDHDGLRVFVDPASLDYLEGSVLDFESGLQAEGFHVENPNVVSECGCGESFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F2</accession>
    <name>R4W9F2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446348.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07545"/>
    <dbReference type="EnsemblBacteria" id="AGN01454">
        <property type="protein sequence ID" value="AGN01454"/>
        <property type="gene ID" value="L593_07545"/>
    </dbReference>
    <dbReference type="GeneID" id="16182061"/>
    <dbReference type="KEGG" id="sali:L593_07545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1545"/>
    <dbReference type="eggNOG" id="arCOG04417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063606_0_0_2"/>
    <dbReference type="OrthoDB" id="120782at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018645">
        <property type="entry name" value="DUF2072"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09845">
        <property type="entry name" value="DUF2072"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="26530" checksum="EE134A05DD649E3B" modified="2013-07-24" version="1">MPHQCTGCGHVFPDGSKEMLSGCPDCGGNKFQFQPSSATGGGDPAGGADAGAAPSEEPPEPPEPPSPGGSVAETVAGAAQSVKNMVGSGNSEPERASAGATGDGPSDHEWPAVGREDATPKQPSEDAAQAGARSATVSPDELPDHDVVDSKLADSEAPEPASTAEEGALSATASEAADAEEPGSAPFTGSGDREKETPDLSELRAELNDQFESIKIVERGQYELNLMELYDREEYIISLMEDGRYAIEVPETWRGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U1</accession>
    <name>R4W9U1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="17" type="ORF">L593_09245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446688.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09245"/>
    <dbReference type="EnsemblBacteria" id="AGN01794">
        <property type="protein sequence ID" value="AGN01794"/>
        <property type="gene ID" value="L593_09245"/>
    </dbReference>
    <dbReference type="GeneID" id="16182586"/>
    <dbReference type="KEGG" id="sali:L593_09245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1898"/>
    <dbReference type="eggNOG" id="arCOG04045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_2"/>
    <dbReference type="OrthoDB" id="7176at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGN01794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="580" mass="60869" checksum="A8729F9BEF13699C" modified="2013-07-24" version="1">MSQQPEQGSPETPEKRADLPSTEVTEGYEKAPHRAMFRAMGYDDADLSSPMIGVANPAADVTPCNVHLDDVTASAYDAVDAGEGMPIEFGTITISDAISMGTEGMKASLISREVIADSVELVAFGERMDGLVTVGGCDKNMPGMMMAMIRTDLPSAFLYGGSIMPGEHEGREITIQNMFEGVGAVATGDMSEDELVEMEHEACPGAGSCGGMFTANTMASLSEALGFSPLGSASPPAEDQGRYDVASETGELVVDAVERGWSPSDFLTRESFENAIALQVAIGGSTNAVLHLLALAAEAGIDLDIEDFDEVSRRTPKIADLQPGGSKVMNDLHEVGGVPVVLNALYEGGYLHDDALTVTGNSIAEELERIDPPAIEALDVDFLYPVDDPIHEEGAIKILTGSLAPDGAVLKVTAKDGTMHHEGPARVFEDEEGAMEYVQEGNVDTGDVIVVRNEGPRGGPGMREMLGVTSAVAGQGHSEDVALITDGRFSGATRGLSIGHVAPEAHDGGPIGLLEDGDHVTIDVPDRVLDVDVPEEELDARREDWTPPEPNYESGVLAKYGALFGSAANGAITNPGARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z3</accession>
    <name>R4W9Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic glycerol-3-phosphate dehydrogenase subunit B</fullName>
            <ecNumber evidence="5">1.1.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10545"/>
    <dbReference type="EnsemblBacteria" id="AGN02054">
        <property type="protein sequence ID" value="AGN02054"/>
        <property type="gene ID" value="L593_10545"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2174"/>
    <dbReference type="eggNOG" id="arCOG04585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047793_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="16"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="481" mass="49624" checksum="862A179C1508CB69" modified="2013-07-24" version="1">MAIATTGGGTMAIDSDVVVIGGGLAGISAALAAADAGAKTRLVTANQSTLRQASGLIDVMGYPPDAAGTDASQRGAPARTDGGPVADPFEHIPDLPEGHPYERVGVDAVRDALAAFDEVVEGYTGEHTDANALVPTNGGAIKPTARYPVHTADGLASDDRDALLVGFESLTDFDAPLAAEHLLAAGVPFAVEGVTVSFPGELRADAKTTRFADLLENDEIPAAKGGTSSGGTGGGAGGGRAGAVHRTRTGSCRAKLVERIDDAIDDATVDPERVGFPAVLGEDRPSAVRIDLSDRLGMPVFEVPTGPPSLPGIRLENQLHEALEARQVWVADGQAVVDFTATDGRDEDRRIEQLQVETPGGGTTPVSAEQYVLATGGLVGRGIDSERDLVREPIFDCHVPHPEDRYDWFADDAFGDHPFAAFGVHVDRSLRPLDADDGIEFENLRAAGSVLGGYDFAAEKSGAGVSIATGHAAGTAAAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA11</accession>
    <name>R4WA11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage T7 F exclusion suppressor FxsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fxsA</name>
        <name evidence="3" type="ORF">L593_10995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447038.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10995"/>
    <dbReference type="EnsemblBacteria" id="AGN02144">
        <property type="protein sequence ID" value="AGN02144"/>
        <property type="gene ID" value="L593_10995"/>
    </dbReference>
    <dbReference type="GeneID" id="16180756"/>
    <dbReference type="KEGG" id="sali:L593_10995"/>
    <dbReference type="eggNOG" id="arCOG03059">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085083_1_0_2"/>
    <dbReference type="OrthoDB" id="101136at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="199" mass="20892" checksum="076A8D33E6EBC110" modified="2013-07-24" version="1">MRKWLLGLLLAIPLVDAAVLAWLGTLLGWAEVVLLVVLTALIGGLLVRAEGRRTIRGIQRSLAEGEPPTDGLIDGGLLIAAGAFLLTPGVVTDAIGFLLVIPVTRAPIRWALKRWIIVPKLDEKTGGFASGNVYTFGFPQPGENEGVDPEDFDLGGPGPFGSTATEETDQNGEAGGSGPSGDDTVDLGSDEYDVEDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA39</accession>
    <name>R4WA39_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447178.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11705"/>
    <dbReference type="EnsemblBacteria" id="AGN02284">
        <property type="protein sequence ID" value="AGN02284"/>
        <property type="gene ID" value="L593_11705"/>
    </dbReference>
    <dbReference type="GeneID" id="16181174"/>
    <dbReference type="KEGG" id="sali:L593_11705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2409"/>
    <dbReference type="eggNOG" id="arCOG09140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036813_1_0_2"/>
    <dbReference type="OrthoDB" id="23405at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="2"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="410" mass="42895" checksum="D7F1E8992F1AF67D" modified="2013-07-24" version="1">MSVVIVGTLDTKGEEIAFARDVIEAEGLDVHLVDVGVLGDPEIDPDTPASDVAAAAGTTLEQLREDEDRGAAMEAMGEGATAICQQLYDDGVLEGVLGLGGSGNTSIATTAMRSLPVGVPKLMCSTMASGDTEPYVGARDVAMLYSVADIEGLNQLSRQVIANAALAMVGMVANEPDVEVEERPTIGITMFGVTTPCVQQARGLLEDRGYETIVFHATGTGGRAMESLIEEGVIDGVLDVTTTEWADELVGGVLNAGEERLEAAGEAGIPQVVSTGALDMVNFGPRDSVPEEFEERQFHVHNPQVTLMRTTVEENVELGEIIAGKLNDATGPTALVLPLQGVSAIDAVGEDFYDAEADGALFDTLRSEVAENGVELIEADAHVNDEAFAQLLVETLDGYMQEVGAAPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA54</accession>
    <name>R4WA54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein synthesis factor GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447253.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12080"/>
    <dbReference type="EnsemblBacteria" id="AGN02359">
        <property type="protein sequence ID" value="AGN02359"/>
        <property type="gene ID" value="L593_12080"/>
    </dbReference>
    <dbReference type="GeneID" id="16180390"/>
    <dbReference type="KEGG" id="sali:L593_12080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2486"/>
    <dbReference type="eggNOG" id="arCOG01562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_1_2_2"/>
    <dbReference type="OrthoDB" id="21155at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039263">
        <property type="entry name" value="GTPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="PTHR43721:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="156"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="568" mass="61544" checksum="2F4CA6591BD230C9" modified="2013-07-24" version="1">MSPPRAALEQALDRGEREGGSVEFKERLSKDTHLSEGRRESLAAQLRHRVLSGDGEATYVLGVTDDGGIAGVAPDVFSETMDVLSLLAEEAECHIDEVQTWGVPVEETSPELDGSMDAAEVPDPRRGHVSSGDVDADRGLVGLATVREGAILETDDEHIVVGTAGHVDHGKSTLVGTLLTGQADDGEGGTRSYLDVQPHEVERGLSADLSYGVYGFDDDGPVRMDNPDRKTDRARIVEEADRLVSFVDTVGHEPWLRTTIRGLVGQKLDYGLLTVAADDGPTRTTREHLGVLLATDLPTMVAITKTDLVSEERLEEAEREIERLLRDADRTPLLVRRHGVEAAIEEIDETVVPIVGTSAVTMEGITVLDELFEHLPKTGGGAAADPFRMYVDRTYSVTGVGAVASGTITSGTVESGDELLLGPMPDGSFREVEVRSIEMHYHRVDRARAGRIVGIALKGVEEREIDRGMALLPRDAEPTPTREFEAEVMVLNHPTRIDAGYEPVVHLETLSEAAAIYPEDGPLLPGDTGRARLRFKFQPYLVQEGQRFVFREGSSKGVGTVLDAAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA60</accession>
    <name>R4WA60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12230"/>
    <dbReference type="EnsemblBacteria" id="AGN02389">
        <property type="protein sequence ID" value="AGN02389"/>
        <property type="gene ID" value="L593_12230"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2515"/>
    <dbReference type="eggNOG" id="arCOG03847">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718286_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16517" checksum="B3080FE2158FA497" modified="2013-07-24" version="1">MTTASTNVEAVVNSLTAACDNGFVPDEIHALSLPAIEAEVEEALTFAERTVEAYGGDSPSVFRTEIDDEIAFGEIQEHVQSVVKAAGDDDAVAVDITPGRKFMSAIAFAAGMRYGADHVYYLYISSTENYFGRLYPEIPRTATQLYDLTEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA88</accession>
    <name>R4WA88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447423.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02529">
        <property type="protein sequence ID" value="AGN02529"/>
        <property type="gene ID" value="L593_12950"/>
    </dbReference>
    <dbReference type="GeneID" id="16180264"/>
    <dbReference type="KEGG" id="sali:L593_12950"/>
    <dbReference type="eggNOG" id="arCOG06221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629821_0_0_2"/>
    <dbReference type="OrthoDB" id="121758at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="80" mass="8969" checksum="40EE6BBDB08CE7F5" modified="2013-07-24" version="1">MHTCRDCKQTFSTELALELHRDTCASGDLRCRKCGERFTEAEATRDGWHYECPTEDCDGAGRGDAIVDVDREGVRTQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF9</accession>
    <name>R4WAF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447778.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14750"/>
    <dbReference type="EnsemblBacteria" id="AGN02884">
        <property type="protein sequence ID" value="AGN02884"/>
        <property type="gene ID" value="L593_14750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181449"/>
    <dbReference type="KEGG" id="sali:L593_14750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3012"/>
    <dbReference type="eggNOG" id="arCOG04227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_1_2"/>
    <dbReference type="OrthoDB" id="99870at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="14914" checksum="2D0D3BA50D9AB1D0" modified="2013-07-24" version="1">MPPTDAQLREVLSLDRIAVVGCSTSPGKAAHDIPKYLLEHGYDVVPVNPFAEEIFEREAYDSLADVPGPIDVVDVFRPSEEVGDIVDAAIERDDVDVIWTQLGISDHDAAGRARDAGMIVVQDRCMKVEHQELMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS24</accession>
    <name>R4VS24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444909.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00015">
        <property type="protein sequence ID" value="AGN00015"/>
        <property type="gene ID" value="L593_00300"/>
    </dbReference>
    <dbReference type="GeneID" id="16180498"/>
    <dbReference type="KEGG" id="sali:L593_00300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.60"/>
    <dbReference type="eggNOG" id="arCOG10301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092206_2_1_2"/>
    <dbReference type="OrthoDB" id="88489at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15805" checksum="A2B43F55C5636422" modified="2013-07-24" version="1">MTHDPDEEHLVILFDGVCNLCSGFVQFVAPRDPEGTFAFASLQSDVARELLADHDVDPDALESIVLLEGDDAYVKSGAVLRIGYHLGGIYRLGWPLRVFPRRLRNWAYDFVANRRYRWFGKKDQCMIPEGDLQSRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSP4</accession>
    <name>R4VSP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445094.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01235"/>
    <dbReference type="EnsemblBacteria" id="AGN00200">
        <property type="protein sequence ID" value="AGN00200"/>
        <property type="gene ID" value="L593_01235"/>
    </dbReference>
    <dbReference type="GeneID" id="16182837"/>
    <dbReference type="KEGG" id="sali:L593_01235"/>
    <dbReference type="eggNOG" id="arCOG01407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_0_0_2"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="38322" checksum="2C7862197E2265B1" modified="2013-07-24" version="1">MKISHYFEWEDAITGGFAESVNNQRTIMDRRGIEYTTSPDLSADLLHLNNMGPRSIYYAKRAHRADVPVVAHTHNTAADFRESFVFSNLLARPLRPYLAYGYSQADHLICPSAHNQSVIETDYTDTPSTVISNGFDAGRYEGWDDPDLREEYLDRYDLEPPVVFMFGHVIKRKGLRTFVETAEAMPDLDFVWFGYVNPAGGTLDKYLQPRETRKLVANSPSNCTFTGYIEDPRGAMAAGDVFFWPSKNENEGMALLEAMHCGKPPVIRSIPTYEWLEDGEDCIKADEAFVEPLRRLCSDERLREEIGSAAARTSEQFSLETVGDDLVALYERLLTERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTJ5</accession>
    <name>R4VTJ5_9EURY</name>
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            <fullName evidence="8">Putative transporter component</fullName>
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    </protein>
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        <name evidence="8" type="ORF">L593_03020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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    <dbReference type="EnsemblBacteria" id="AGN00555">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <begin position="41"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="181" mass="18131" checksum="28065A60E5865BF0" modified="2013-07-24" version="1">MLSDLITVALAADLVAATSAVDIAPASIASDPFPNGISRYAVGGLLVGLGTAVIYLGTGISAGASTFLESTLSYVSGQSRFQRYVASRDWRLLFTGSIVLGAAVYAVTIQGGAWTTDVHPWRLLVGGIFVGVGTRVGKGCTSGHGVCGVGSASKTSIAGVVTFLLVAIVTAQLVAAAGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUU1</accession>
    <name>R4VUU1_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01000">
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        <property type="gene ID" value="L593_05255"/>
    </dbReference>
    <dbReference type="GeneID" id="16182138"/>
    <dbReference type="KEGG" id="sali:L593_05255"/>
    <dbReference type="HOGENOM" id="CLU_1745623_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="149" mass="14473" checksum="13030EA72D5B944B" modified="2013-07-24" version="1">MHTPTSDARSAGGIQARLLGPTGGRALPLAVVFGAAVSMLAWTLLPEAFAAMALLGPLVAGYLHNAGPRAGATAGVATLALAAPLQFALASVSALPSPYPLSVPTDPAGAELALFLAITAGLVALLVALGGALGALGAELGVSGVDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUZ1</accession>
    <name>R4VUZ1_9EURY</name>
    <protein>
        <submittedName>
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            <ecNumber evidence="3">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444985.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00680"/>
    <dbReference type="EnsemblBacteria" id="AGN00091">
        <property type="protein sequence ID" value="AGN00091"/>
        <property type="gene ID" value="L593_00680"/>
    </dbReference>
    <dbReference type="GeneID" id="16181357"/>
    <dbReference type="KEGG" id="sali:L593_00680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.138"/>
    <dbReference type="eggNOG" id="arCOG01541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030481_0_0_2"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="279"/>
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        </location>
    </feature>
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            <begin position="335"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
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        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="592" mass="63262" checksum="F6ABD77DAF8BC368" modified="2013-07-24" version="1">MVLDVIHPAALVLLAAVLAWRLPRNVGHALGVVATASAAAISWFAPEGTHYAVDLFGTFPAVLYNVDQFSALMGLIFGFIGAMAVLYSWYSGADRVQTAFALGYVGTSFGTVFAGDWLTMIFFWELMAVTSTLLVWHYGGAAVRAGFRYALLHGIGGSLLLAAIVWQYAEVGSLLFSASTGMEGTTAQVLAAVGIGVNVGFVGLHAWLPDTYPRPHVAASVFLCVFTTKTGVYGMFRAFPEGHLWIAYMGGAMAVFGAFAALLQSDMRRLLSYHIQSQVGYMIAGVGIGTSLAVAGAFGHVFNHILYKSLLFMAVGVVIYRTGEESLDEIGGLGRTMPFTAITFTVAALSIAGFPGFNGFVSKGIVIAEAHHYEKYEALWYLLLLGGVGTFLSFIKLGYFAFVEGSYDGEVKDANVGQSVGMGLVAALCVLLGIYPAALFEILPNSHVLGWQTFESGHYEFEVFTASHLIEGVALAAAGLVGFAILRAPLHRIGTVPDVDWLYNRAGFVGTRWFVILVTELYAVVDRGAVWLADTSMTVASDPEAYVRRVPGSERALGEPGERYRPLRSGIGRSILLVTLVATVVLVAVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVK9</accession>
    <name>R4VVK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446124.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01230">
        <property type="protein sequence ID" value="AGN01230"/>
        <property type="gene ID" value="L593_06415"/>
    </dbReference>
    <dbReference type="GeneID" id="16181731"/>
    <dbReference type="KEGG" id="sali:L593_06415"/>
    <dbReference type="eggNOG" id="arCOG02804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099321_0_0_2"/>
    <dbReference type="OrthoDB" id="69155at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="22396" checksum="09189E3FECB5E7E2" modified="2013-07-24" version="1">MSDDLPPAERSKVGRLIAENDLSGAGETLERRWTGEAGERASLRDLADWFNQRVLEAVLAEHDRQPAAETTETTYRLLTDDEVGPTAQTQTRRDLERKGIDVDDLEADFVSHQAIHTYLTSYRDASLEDDVRSSSLEDVEEAIDRLQSKTATVTKSNVERQRAAGNVDVGEVDVIVTIDVVCTDCGDSFTFGELIEAGGCSCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVL2</accession>
    <name>R4VVL2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCA-adding enzyme</fullName>
            <ecNumber evidence="9">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cca</name>
        <name evidence="12" type="ORF">L593_01690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445185.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01690"/>
    <dbReference type="EnsemblBacteria" id="AGN00291">
        <property type="protein sequence ID" value="AGN00291"/>
        <property type="gene ID" value="L593_01690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181760"/>
    <dbReference type="KEGG" id="sali:L593_01690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.343"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_0_0_2"/>
    <dbReference type="OrthoDB" id="82755at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0692">RNA repair</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="10">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="11">
        <location>
            <begin position="160"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="461" mass="50628" checksum="A92AF6148BB0691E" modified="2013-07-24" version="1">MDDLDAVLDRARELVTPDEAERSALATATERLCERAERAIADREVEAEIALVGSTARSTWLPGERDVDVFLQFPADLGRESLEEHGLAVGHAVLGNGHEEYAEHPYVTGTVAEGSLDAIAVDVVPCYDLEDATEIRSAVDRTPFHTEYVQDRLDDDLATEVRLAKAFATTIGIYGSNLRTRGLSGYLTELLVLVYGGFRGLLEAAADWQPPVVLDPVDHGTATFDDPLVVIDPTDPERNVAAVCSAANVARLQHYAREFLDDPDPAYFETEKVPPSEVPAITAEGLCEHVERRDTTPVAIRFTAPDLVDDDLYPQLRASLGGVVGLLERKGFDVLRSTTAVAEGEAILLVELEVTHRPAVERHEGPPVQVREHADNFYDAYADDPDVYGPFVEEDRYVVERPREATNAIDLLDGDSLFDVRHGAGVERRLQSEYEVLVGDDLVDLLPAFADPLAEYFDPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVL9</accession>
    <name>R4VVL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446134.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06465"/>
    <dbReference type="EnsemblBacteria" id="AGN01240">
        <property type="protein sequence ID" value="AGN01240"/>
        <property type="gene ID" value="L593_06465"/>
    </dbReference>
    <dbReference type="GeneID" id="16181749"/>
    <dbReference type="KEGG" id="sali:L593_06465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1318"/>
    <dbReference type="eggNOG" id="arCOG06125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065536_1_0_2"/>
    <dbReference type="OrthoDB" id="38006at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="312" mass="34106" checksum="4DDE06C2215FC82B" modified="2013-07-24" version="1">MRSLDKMIVSCAVTGAIHTPTMSPHLPVTPAEIATAAIEASEAGASIVHVHVRDPETGQPVNDWDLFREVAERIAAETDVIVQPTTGGAPMDPPEERVGVVPELEPEMASCNMGSINFGLYQLLDKYDDWEYDWEPEYLAGTRDLIFQNTFADLETVLPIFNEHDTKPELECYDVGHLYNAKHFVDRGLIETPIHLQFVTGIHGGIASTAANLTHMVRIADELFGEDYSFSVIGAGRNEFSMATQAISMGGNPRVGLEDNLYLGPGELAESNAAMVEKIVRLGDELTGREPAEPDEVREFLGLKGLENTAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVT7</accession>
    <name>R4VVT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445265.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02100"/>
    <dbReference type="EnsemblBacteria" id="AGN00371">
        <property type="protein sequence ID" value="AGN00371"/>
        <property type="gene ID" value="L593_02100"/>
    </dbReference>
    <dbReference type="GeneID" id="16182795"/>
    <dbReference type="KEGG" id="sali:L593_02100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.427"/>
    <dbReference type="eggNOG" id="arCOG04562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843631_0_0_2"/>
    <dbReference type="OrthoDB" id="85383at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="347" mass="36174" checksum="E77B6A4BB5F63AAF" modified="2013-07-24" version="1">MFIGHALLAFALAVLVAEWRGWPTHRAFAIGIATGLFAAAPDVDMLWTVVAIEPSELVVGTRIQPGEFWGSAHGIHRSMTHSLVAAAVAGPAFGLWTLRRSRGADPLGWSTDDASGTDGFDRHTLVSVALALAGLSVLVTAAVLASGFVGGFVMTAFVLAGLAIATASRIYLGLSPVEIGIAAVAGIASHPWGDLVTGEPPALLYPFDVQLISERVLLSGDPTLHLLGAFAIELAAVTIAAIVLARAADLDPIRLVDRRAAAGVLYGAGAVVMVPPTINLSYHFVFSILTVGVVLGGLRRSPRSPYSLRNLYHRFVGDPEAALRTTFTALAGIAVALVSYAVVYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVZ6</accession>
    <name>R4VVZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446279.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07190"/>
    <dbReference type="EnsemblBacteria" id="AGN01385">
        <property type="protein sequence ID" value="AGN01385"/>
        <property type="gene ID" value="L593_07190"/>
    </dbReference>
    <dbReference type="GeneID" id="16182461"/>
    <dbReference type="KEGG" id="sali:L593_07190"/>
    <dbReference type="eggNOG" id="arCOG08136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175997_0_0_2"/>
    <dbReference type="OrthoDB" id="122889at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8769" checksum="1AF6D56672519140" modified="2013-07-24" version="1">MAGPLRVEAGEITADEILDALREGRRVVVSTEVLGADHEVTLRHDGSQYYCDTPTTLHTHESEDEMRQCIHNQGYASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW28</accession>
    <name>R4VW28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445365.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02600"/>
    <dbReference type="EnsemblBacteria" id="AGN00471">
        <property type="protein sequence ID" value="AGN00471"/>
        <property type="gene ID" value="L593_02600"/>
    </dbReference>
    <dbReference type="GeneID" id="16180217"/>
    <dbReference type="KEGG" id="sali:L593_02600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.527"/>
    <dbReference type="eggNOG" id="arCOG02820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017222_0_0_2"/>
    <dbReference type="OrthoDB" id="5870at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="5">
        <location>
            <begin position="580"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="841" mass="90272" checksum="F2AFAB858565A1D3" modified="2013-07-24" version="1">MDYPEASNFLFGLRRFGPKKGTESTADLLAELDDPHESVDFVQVAGSNGKGSTARMTERVLREAGLSVGLFTSPHLEDLRERIRVDGRKIPEGAVSRFVERTREYIVDRGVEGASPTFFEATTAMALWHFAQEDVDVAILEVGIGGKLDATSVVDPIASAVTTVSLEHTGLLGDTVEEIAHDKAHVAPTDRPLVTAAEGAALATLEADVGDLVTVGLASDQSAEDDPASSDDEQPSDQSTDWPDVLARYGGRANHTEATVELEGTVDGQEWSVETRLPVLGAHQAENAGVAAVLARQVCNEAGIALASEDLARGLRQAHWPGRFEVLSQDPLVVLDGAHNAGACERLAEVLAEFDYDELHLAAGIMHDKPQGEMAAALPHCDRVVTCRPDLDRAEDPAVLAGVFEDAGADRVEVGGSVQGAVENVIEGADLDDCVLVTGSLFTVAEARSRWTRLQTPKQVDTLGEAKTTLERAGVTDAGIWRMRGKAVHRVVETRLQRRQAEFVKQELLALGGECAVSAIDHDGELLRVVLLGTLSQFRRLGEALEDQPYGLPRIGDELRRQLGIEVPEHEPTYPWQEGTAVMGICNVTPDSFHDGGEYNRVEQAAERARQQVADGADIVDVGGESTRPGADPVPIEEEIARVVPVIEEIADLDAMISIDTRKADVARAALDAGADIVNDVSGLEDPAMRFVAADHDAPLVVMHSIDAPVDPDRDVEYDDVVRDVVESLHERVLLAQQAGLDREQIVVDPGLGFGKSADESFELLDRLPELRALQCPIMVGHSHKSLFAAAGYDHGERLEPTIAATALATDRGADIVRVHDVAENVAAVRTTEAARSAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW57</accession>
    <name>R4VW57_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446349.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07550"/>
    <dbReference type="EnsemblBacteria" id="AGN01455">
        <property type="protein sequence ID" value="AGN01455"/>
        <property type="gene ID" value="L593_07550"/>
    </dbReference>
    <dbReference type="GeneID" id="16182149"/>
    <dbReference type="KEGG" id="sali:L593_07550"/>
    <dbReference type="eggNOG" id="arCOG03630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335027_0_0_2"/>
    <dbReference type="OrthoDB" id="98806at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="20827" checksum="4C0363E4DEEFBAD6" modified="2013-07-24" version="1">MTQWVEDVEGGRQRGLRGLAKAWVEVLVRPRRFFAEGIAPGDQGPGLTFAIAVVLVAQGTRFAFGTDPYPVVDGRPILSGAFWLVAVAVLIAPVVLHVVGALQTVILAAGAEDRGGVSETVQILAYASAPCVLAGVPFPPLQVVVGLWAGALYFVGLAAVHDFAPSRALLLGAIPAVVAYGYAFRTIAAAETLAHDLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW68</accession>
    <name>R4VW68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein MoaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445410.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02825"/>
    <dbReference type="EnsemblBacteria" id="AGN00516">
        <property type="protein sequence ID" value="AGN00516"/>
        <property type="gene ID" value="L593_02825"/>
    </dbReference>
    <dbReference type="GeneID" id="16180345"/>
    <dbReference type="KEGG" id="sali:L593_02825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.571"/>
    <dbReference type="eggNOG" id="arCOG01530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_2_2"/>
    <dbReference type="OrthoDB" id="104538at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="4">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="20061" checksum="4AD0A062748517C2" modified="2013-07-24" version="1">MGEEGASGEDPDDLTHTDAEGAVDMVDVGDKPDTARRAVARGRLRLQPSTIEAITASEIEKGDVLATARVGAIQAVKHTWETIPLCHQIPITNVETTFDLHDGPVHADGDGDSESAVGDVDDVGSSPAVELTVAVETTGKTGCEMEALEGVTTGLNVVWDMVKSAEKDADGGYPTAQIEGVGVVEKTKRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWB1</accession>
    <name>R4VWB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase HXTX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446409.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07850"/>
    <dbReference type="EnsemblBacteria" id="AGN01515">
        <property type="protein sequence ID" value="AGN01515"/>
        <property type="gene ID" value="L593_07850"/>
    </dbReference>
    <dbReference type="GeneID" id="16182242"/>
    <dbReference type="KEGG" id="sali:L593_07850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1608"/>
    <dbReference type="eggNOG" id="arCOG01738">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135999_0_0_2"/>
    <dbReference type="OrthoDB" id="112029at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="166" mass="18135" checksum="6A178404A0C3E46B" modified="2013-07-24" version="1">MYSLNAAVPGRVRRIAGDLYPHLASFADVREDHSICVKRLGDDEPYKTLADRARTVLADAPAFEVAVTGIDYFETPTDGTDPVVYLTVESPGLLQVHKTLVEAFGALPGLEGDEYVPHVTLARDGEIADAERLAEREIEPVTWTVSELEFTDAHHDHAIGTIPLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWD4</accession>
    <name>R4VWD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">L593_08000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446439.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08000"/>
    <dbReference type="EnsemblBacteria" id="AGN01545">
        <property type="protein sequence ID" value="AGN01545"/>
        <property type="gene ID" value="L593_08000"/>
    </dbReference>
    <dbReference type="GeneID" id="16182285"/>
    <dbReference type="KEGG" id="sali:L593_08000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1639"/>
    <dbReference type="eggNOG" id="arCOG04462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164833_3_0_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="84" mass="9329" checksum="F661C623B59F50FD" modified="2013-07-24" version="1">MAAFTATVTVRLKSGVLDPEAATTQRALERLDFELDDLRFADRYEIDVDAADADAAAERAESMAERLLANPTIHDYDVEVEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX66</accession>
    <name>R4VX66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rhomboid family protein/GlpG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_09375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446714.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09375"/>
    <dbReference type="EnsemblBacteria" id="AGN01820">
        <property type="protein sequence ID" value="AGN01820"/>
        <property type="gene ID" value="L593_09375"/>
    </dbReference>
    <dbReference type="GeneID" id="16182692"/>
    <dbReference type="KEGG" id="sali:L593_09375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1928"/>
    <dbReference type="eggNOG" id="arCOG01769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_1_0_2"/>
    <dbReference type="OrthoDB" id="82519at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="32413" checksum="C98A048DD739EAD7" modified="2013-07-24" version="1">MAECDACGKSENMPYECKRCGGTFCTEHRLPEAHDCPGLNAWNGSEGGGALGGGPSAGGPNAGQGPSASGGIGSIGTSDDGLFDMPTGTGGWRGYFRNNMTFVFLLGMWLTYAAQLFLRLSGNGGVFGLEGDIFIAKTWAPEAVWTYFTSIFAHGGIAHIAFNSIALYFFGPIVEKKLGSKRFTLLFLGSGLLASVLSVGVPLAIGETSAGLGASGAILAVLGVLTVLNPDLRVLLFFAIPMPLWILTIGYGLFSVFALAAGGVGAGGIGHIAHLSGLLIGLAYGQYLKEQGMTAPRQLQFGGGGGGMGGGRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX85</accession>
    <name>R4VX85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445770.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00876">
        <property type="protein sequence ID" value="AGN00876"/>
        <property type="gene ID" value="L593_04635"/>
    </dbReference>
    <dbReference type="GeneID" id="16181033"/>
    <dbReference type="KEGG" id="sali:L593_04635"/>
    <dbReference type="eggNOG" id="arCOG06265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154324_0_0_2"/>
    <dbReference type="OrthoDB" id="93385at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14803" checksum="DCF6795B60223F3F" modified="2013-07-24" version="1">MDRLRLPALAGTVVSLLTAVAVLVPYVLADAGADTIATYYDFGLVTGLTVLMVALVTLVVFASGWRGRSDPATAAGAALGLGFVATLLAASWALAVPYDVVVQLTTESWFEYHRWAVVGSSVAMVVCGLWYAYVLRLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXL8</accession>
    <name>R4VXL8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="12" type="ORF">L593_05285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445900.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05285"/>
    <dbReference type="EnsemblBacteria" id="AGN01006">
        <property type="protein sequence ID" value="AGN01006"/>
        <property type="gene ID" value="L593_05285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182403"/>
    <dbReference type="KEGG" id="sali:L593_05285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1079"/>
    <dbReference type="eggNOG" id="arCOG02896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_2"/>
    <dbReference type="OrthoDB" id="1024at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="11">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="827"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="614"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="894" mass="96517" checksum="94F2D2FC6BD94CFB" modified="2013-07-24" version="1">MDAAEGIVGEFAALKRESGADVLAMQVGDFYEFFGEDAELVCRELDLKQTSKSSGGESYAMAGVPLSELSPYLQALVERGYRVAVADQRDEGGDHSRELTRVVSPGTLLSTTDADARYLATVVAETDRYGVALADVTTGRFYVTGVGGTLGDLLAELARFDPVEVLPGPDLREDDDAIATLRGDLDATLTLHEAEAFAPGAAAHRLREQFGEGAVESVGLEAAAPAVQAAGATLDYVETTGAGVLASFTRLQRYRDREHVALDATTQRNLELTETMQGDRDGSLLATIDETVTSPGRRRLGEWLARPRRDRETIATRLDSVDALGSSALARERLREELSEAADLARLASKATHGSADAGDLLRVRDALDVLPAAEAVIEDDATLAESPLPEILQRPDRRAAAELRAELDAALAEEPPASLSEGGLIARGYDDELDAIVERHEAALEWIEGLDDRVSSELGITHVSVDRNATDGYYVQVGNSEADQVPDHFRQIKSLKNHERFVTEELEEREREILRLEEERSEIERELFEEIRETVASQAALLQDAGRAIATVDALASLATHAAEQGWVRPELGPAGGPVEIERGRHPVVETTTTFVPNDARLGDDRRFVIVTGPNMSGKSTYMRQTALIVLLAQVGSFVPADAARIGLVDSIYTRVGALDELAQGRSTFMVEMQELANILHSATEESLVILDEVGRGTATYDGISIAWAATEYLHNEVGAKTLFATHYHELTTLADHLDRVANVHVAAEETDGEVTFLRTVREGPTDRSYGIHVADLAGVPEPVVDRSEGVLDRLRQEKAIEARGGSSGDGEPQQVVFDVGSGELRTASADGGVGAQRPRKSGPESSDDDASEQLDPETKAVLEELADLDVNETPPVELLAKVQEWQESLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXS4</accession>
    <name>R4VXS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10600"/>
    <dbReference type="EnsemblBacteria" id="AGN02065">
        <property type="protein sequence ID" value="AGN02065"/>
        <property type="gene ID" value="L593_10600"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10600"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_5_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="91" mass="10274" checksum="54D9ABD1493B431F" modified="2013-07-24" version="1">MLTALLERNPLDATDPSFVDGAFGQSTDGFVDPERARIAIHHTHLPKLEADGYVEWNPEDETIVKGPNWEEIAPLVELLSENEDEFPMQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU4</accession>
    <name>R4VXU4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445980.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05685"/>
    <dbReference type="EnsemblBacteria" id="AGN01086">
        <property type="protein sequence ID" value="AGN01086"/>
        <property type="gene ID" value="L593_05685"/>
    </dbReference>
    <dbReference type="GeneID" id="16181467"/>
    <dbReference type="KEGG" id="sali:L593_05685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1164"/>
    <dbReference type="eggNOG" id="arCOG00168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018277_0_0_2"/>
    <dbReference type="OrthoDB" id="86965at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="296"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="540" mass="56439" checksum="5443A20778A658BB" modified="2013-07-24" version="1">MSTIDRHDLVTGDGGLRNGIAVGLLTAALLTFLASWLVLFGQVGDGIDLLGVPLVDVLALSLVVQGAGLGLLGLGSYYGYFPSNPSPSSGLLTGFLVGFLWTGTLGGIGSVQLGLGTIGWVGVAILGGIAAFVAVVLPSEDVGSTVPLAALIAPLGLAILVGPLSPPWVWEPNWTDAIFPGSEVLPLLFIAVSVVSAWSVAKAQEGFGARGRQRGAYYLIGTSVAGMLGTLGLIIWFIVDNGHEVFLTGAEIGGLDGEFTIPFLGVTIPWLHVKLPFVTNVPGGLFVEIPGVWPAVLGTIWLVIGAVVVAVPLGIGSAIFLTEYVERGRITQVVEVVTNGLWSTPSIVFGLFGLAFLMPRLSGGGRSLIVGQIVLGFMLLPLVMITSREAILSVPDEYRDASAALGVTRWQTIRSVVLPAAMPGVITGVILGVGRIAGETAPLLLVFGGPPFPSDNPAVMKSFEFSLQPPFITNEALTQAGTALPYQLYTSITAGVWNKEIYTTTEFGWGTALVLLGVVLLFYGIGVGGRMYFERKLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXZ4</accession>
    <name>R4VXZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447034.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10975"/>
    <dbReference type="EnsemblBacteria" id="AGN02140">
        <property type="protein sequence ID" value="AGN02140"/>
        <property type="gene ID" value="L593_10975"/>
    </dbReference>
    <dbReference type="GeneID" id="16182373"/>
    <dbReference type="KEGG" id="sali:L593_10975"/>
    <dbReference type="eggNOG" id="arCOG11070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200168_0_0_2"/>
    <dbReference type="OrthoDB" id="125727at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="7881" checksum="7A86C30721F0CEAC" modified="2013-07-24" version="1">MQLLPESDTGFALVMGAFTLLLFVLAVGIVSATSPSGVGRLELAGFAVGFALFIGIYFFSMSADRFLRGDDKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZQ0</accession>
    <name>R4VZQ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447619.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13930"/>
    <dbReference type="EnsemblBacteria" id="AGN02725">
        <property type="protein sequence ID" value="AGN02725"/>
        <property type="gene ID" value="L593_13930"/>
    </dbReference>
    <dbReference type="GeneID" id="16181428"/>
    <dbReference type="KEGG" id="sali:L593_13930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2850"/>
    <dbReference type="eggNOG" id="arCOG04718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340042_0_0_2"/>
    <dbReference type="OrthoDB" id="122393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5808" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10367" checksum="2E14DA7A875DD294" modified="2013-07-24" version="1">MVDKPNSGELFGIPYNFEKPSMRRLLSSYWQPGDGMLVKKPFGVGYTLNLANWRSWVVIGIAGALLWQERSGSDEAMAEESSSDEPVEVLVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W000</accession>
    <name>R4W000_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA C-acyltransferase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09280"/>
    <dbReference type="EnsemblBacteria" id="AGN01801">
        <property type="protein sequence ID" value="AGN01801"/>
        <property type="gene ID" value="L593_09280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1906"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40254" checksum="E8B40E1F10AB072B" modified="2013-07-24" version="1">MGVGMTRFDAHDRPLAELFGEAAFAAMDDSEIERDAIDAFYLGNAMGGQIEHASHLAPQLASHVGLAGIPCQRFEDACATSSNAFKHAVEAVESGRHEAVLVGGVERCTPETGIDTAEMTTQFATAMHELYEQPVGLSFPGVFGLLTDRHMHEFGTTEEHLAEVAVKNHFHGSLNPDAQHGREITVEDVLDSPVVASPFRLYDCCPFSDGAAALVVTNEETAERAHADGGGEPIAVQGVGHATDIVPIADKIEPGVTQAARDAAEQAYDAAGVGPGDVDVVELHDCFTGAEILATEALGFFDRGEGGPAAAEGRTRIGGELPVNPSGGLKAKGHPIGATGAAQIVELVTQLRGDAGDRQVEDPEVGLAHNLGGDTATTIVSILEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0A7</accession>
    <name>R4W0A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446815.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09880"/>
    <dbReference type="EnsemblBacteria" id="AGN01921">
        <property type="protein sequence ID" value="AGN01921"/>
        <property type="gene ID" value="L593_09880"/>
    </dbReference>
    <dbReference type="GeneID" id="16182844"/>
    <dbReference type="KEGG" id="sali:L593_09880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2034"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033880_1_0_2"/>
    <dbReference type="OrthoDB" id="7855at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="HELICc2" evidence="3">
        <location>
            <begin position="392"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="68990" checksum="2B5CB7A18A1A5FD3" modified="2013-07-24" version="1">MHTERIHDEFPAPSYRGHQEDALDRIAAAFDDGNDVVLVRAPTGSGKSLLARAICGTAKTHDDTDHASEAVGSYYTTPQVSQLDDVSDDDLLEDFAIIRGKSNYDCILPEERDTPVDQAPCARKAGYDCSVKDRCPYFASRNLAANRQIAAMTLAYFMQTAGSEVFRKRDVCVIDEAHGLAEWAEMYATIDLGPYTVPVWDDLSVPNLDEQDAGPVEAAFHFAETAIAACEHRKDALLGQAELSASEVAERDRLQERIGDLQWFREDYRDTDSATEWLIDQAENRAITIKPLEPERYLHHTVWDRANRFALLSATILDKEAFCRQVGLDPANVAMVDLPHTFPLEHRRLYDVTCGRMTTEHRDATLPRMAETIARLMDEHDDEKGLVHCHSYAIQDRLAELLRDRGKDARLWTHDSEDRDGTLVAWKRSDGPGVLLSVKMEEALDLEGDLARWQVLCKAPFPNAGDARVAHRLEQDRWAWYYRTTLRTVIQGCGRVVRSPDDYGATYVADDALLDVFERAGSVMPDWFREQVDEMRAPDIPGLPVEASGSAAAVAAGGDATGTSDGRDAGTATANASTKSGSGSAAGSSTDGAADAATADTGQTDSSDDDGDDSRSAKGSPLGDVWGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0B1</accession>
    <name>R4W0B1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446820.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09905"/>
    <dbReference type="EnsemblBacteria" id="AGN01926">
        <property type="protein sequence ID" value="AGN01926"/>
        <property type="gene ID" value="L593_09905"/>
    </dbReference>
    <dbReference type="GeneID" id="16182852"/>
    <dbReference type="KEGG" id="sali:L593_09905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2039"/>
    <dbReference type="eggNOG" id="arCOG06507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340716_0_0_2"/>
    <dbReference type="OrthoDB" id="63856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="205" mass="23322" checksum="19FBD5D98EF22308" modified="2013-07-24" version="1">MDPEDVREGWAERTGKYSPAYYAEIGPNEVSETLVQVLGHYATDDARILEVGCGSGRHLEHLRNHGFANLTGIDINDESFEVMAEQYPRLAETGTFLTGEMETLLPEFDDDSFDVVYTVEALQHVPPEDAWVFDEFERLTTDLLVTAENEGNSPDRGRGEEDVSMVNDDFPLFHRDWKAVFSERGFAQLLREPTSRDTIRVFRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0E4</accession>
    <name>R4W0E4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component 2</fullName>
            <shortName evidence="5">RNase P component 2</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pop5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnp2</name>
        <name evidence="7" type="ORF">L593_10130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446865.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10130"/>
    <dbReference type="EnsemblBacteria" id="AGN01971">
        <property type="protein sequence ID" value="AGN01971"/>
        <property type="gene ID" value="L593_10130"/>
    </dbReference>
    <dbReference type="GeneID" id="16181951"/>
    <dbReference type="KEGG" id="sali:L593_10130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2088"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137733_0_0_2"/>
    <dbReference type="OrthoDB" id="89278at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="19655" checksum="8EB06243D31DEBCB" modified="2013-07-24" version="1">MKHLPKHLRPRYRYLAVGLESWPDASFDRRAFQREVWDATRALCGDPGSAAIDPTVLRFDRDGSMGRAILKVRRGTVDRARAALACIDAVGGDAVGLRVRGTSGTVRACEEKYLGGPPEPSEERTVVYQRQERTATVRSPRVDVRTDAGFLGATESDCDRTDRDDTEPNCDTESDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0P9</accession>
    <name>R4W0P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447020.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10905"/>
    <dbReference type="EnsemblBacteria" id="AGN02126">
        <property type="protein sequence ID" value="AGN02126"/>
        <property type="gene ID" value="L593_10905"/>
    </dbReference>
    <dbReference type="GeneID" id="16180983"/>
    <dbReference type="KEGG" id="sali:L593_10905"/>
    <dbReference type="eggNOG" id="arCOG13177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091233_0_0_2"/>
    <dbReference type="OrthoDB" id="129228at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="132" mass="14870" checksum="B9F686F5A819E678" modified="2013-07-24" version="1">MIADGVAYEVTVEFGDGDRDRFESWFPNVVLDWTTQPDIRSFRVHRGVDADGERLRFVFTFETEDDWERFVQRSAHRERMDHLESVAETVRTTLWTPGAIALGGDGPAIVPATGTTETTIDPSDRAEVEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0S8</accession>
    <name>R4W0S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447055.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11080"/>
    <dbReference type="EnsemblBacteria" id="AGN02161">
        <property type="protein sequence ID" value="AGN02161"/>
        <property type="gene ID" value="L593_11080"/>
    </dbReference>
    <dbReference type="GeneID" id="16182344"/>
    <dbReference type="KEGG" id="sali:L593_11080"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="35542" checksum="671A6B33F45C10C2" modified="2013-07-24" version="1">MTVTIGFVGAGGIAEWQHFDIVEARDDVEVAGICDVNQAAASEAAERFDATAYTDHEKLYDGEDLDAVFVCIPPFAHGPAEIAAAERGIDLFVEKPLALSVDRAREIHQAIDAADVLAGVGYDWRYSRGVERAQELLDGRTVATIEGRWWGGVPGDDGHWWREFEKSGGQIVEQATHVYDTVRLLAGDVEAVSGAGSHRLVDAVDFADSTSVTMEHESGAISHVSTTCAAEDHDAHLEVVADGATLRITEEEITGTVDGEDIEESFDVNPYAVEVDAFVEAVAAGDPSPIRSTYDDAFDTFALTMAANEALDADGRVQPAAIDDGTDAGEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W100</accession>
    <name>R4W100_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyl transferase, C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11355"/>
    <dbReference type="EnsemblBacteria" id="AGN02216">
        <property type="protein sequence ID" value="AGN02216"/>
        <property type="gene ID" value="L593_11355"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11355"/>
    <dbReference type="HOGENOM" id="CLU_033347_2_3_2"/>
    <dbReference type="OrthoDB" id="77238at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="2">
        <location>
            <begin position="85"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="3">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="39064" checksum="64D9B5AB5D0025AC" modified="2013-07-24" version="1">MLGEMYVPGDRTLDVPEDAEIVYASCTRPGHEVLETLLEYDAPITEIVSITPEMARRGSSSKYRSFAETADAHDLPIYYPQEYGMDDPADLDHFQSIDADVMIVNGWQRLVPGEILETFEYGALGNHGSAFGLPRGRGRSPLNWSLIEDLDRFLLSIIQLDPGPDSGEVVATKKFDLTTYDDIQTLYHKVTMAIEEMLFDSLGPVLREEIEYGEQRGEVTYYPKRNPEDGAIHWGNTTRDIYDLVRAVTDPYPGAFTLDDGTRVDIWEAIPFSDDFAFGVEPGTIVETFEAGDFVVATPDGTLLVREWDAEDWAPEPGVQFESRGEHDRVDRYEHRNHLTGSGAPDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W145</accession>
    <name>R4W145_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447175.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11690"/>
    <dbReference type="EnsemblBacteria" id="AGN02281">
        <property type="protein sequence ID" value="AGN02281"/>
        <property type="gene ID" value="L593_11690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181778"/>
    <dbReference type="KEGG" id="sali:L593_11690"/>
    <dbReference type="eggNOG" id="arCOG06885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064448_0_0_2"/>
    <dbReference type="OrthoDB" id="52400at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="172"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="317" mass="36618" checksum="FF4BA11FE4263487" modified="2013-07-24" version="1">MDEHIARIQEHQLRTVWENEERGFTRWLGDNIELLGAELGIEIEDARTEETVGDFSSDIVAREMNTGETVVIENQYGNTDHDHLGKLLTYSSGKDAGFSIWLAEHFRPEHRSVLEWLNESGPNDVKFFAIKPRVLSIADTDERGFEFEIVVEPNDWEREITDESLSETERSYREYFADLVEAYSERRPRWSELKPGPRNYLTFSAGIAGVSFGWVFHQGPEYCVELYIQTADAEQNLAIFEALKEQRAEIESNLDTDLVWQRLPEKRACRIKWSKSIDGKITELDGDQQGQLIEWGVDAMDSFQDEFEPRIASLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1D9</accession>
    <name>R4W1D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447305.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12360"/>
    <dbReference type="EnsemblBacteria" id="AGN02411">
        <property type="protein sequence ID" value="AGN02411"/>
        <property type="gene ID" value="L593_12360"/>
    </dbReference>
    <dbReference type="GeneID" id="16179889"/>
    <dbReference type="KEGG" id="sali:L593_12360"/>
    <dbReference type="eggNOG" id="arCOG08186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051459_0_0_2"/>
    <dbReference type="OrthoDB" id="78261at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="46081" checksum="54A7C9E496916667" modified="2013-07-24" version="1">MTVARDAFRRSTRALLVLGILAGINSGGGLALTQPEQLSLATDVYFHAATAMLEGGDLYATTPPGLPDYHYIYPPIVVVLFLPHALLGSEAAAYAFQTVLNLVAGLGIALVLLRAISRRGIALPRTDRLLVGGFALLSAWSASQLVMGQVNLWLALAIALGLDWLDRERFAVRTGSADGPPDRSTWAGVAFALAALVKLFPAVLGLWLLRTRRYRALVAAIATGLGGLLLGALVFGPDLTIEYLTEVLVGRFEGETFEGSPDPDRNHTTARRMLAATFGGSSPIVTPLAIALVLPPVAYCYRDVSTESRRLTAILATLVGTLLIMPLQPLYFSFLYFPVVVLVVTLDAGRPRKLLVAGTIFTFVLAGPESLELLATILPDSLGASVVDAGNAIFSVILPPTVGMWLLLAACVAVHAGVDNDAVEWRSSDGATAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1L6</accession>
    <name>R4W1L6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447410.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12885"/>
    <dbReference type="EnsemblBacteria" id="AGN02516">
        <property type="protein sequence ID" value="AGN02516"/>
        <property type="gene ID" value="L593_12885"/>
    </dbReference>
    <dbReference type="GeneID" id="16180325"/>
    <dbReference type="KEGG" id="sali:L593_12885"/>
    <dbReference type="eggNOG" id="arCOG05411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846271_0_0_2"/>
    <dbReference type="OrthoDB" id="28854at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="37256" checksum="127E2100CCAFCDAC" modified="2013-07-24" version="1">MVTTLDNTEYADVRGFNYQPSHASHGMEIWGTDFQPSLMRKELWIGKQHFPGMNTVRLWLSHDAYLRFPERMPERVGEVLDMGADYDVEFIVTLFNGWSSYPHLGGLHPQSLREWHDGELYEEGFEPYVDAILGEHADHDSVLAWDLCNEPLLSIQNRNALEDLEVDRSLVIYQFLERVHERIHSHDPAAPTTVGNLGTPAAVEIFEPLAEVLSTHPYLIWNRGRTPEELRDSIDEIVSFANEVGKGLIASETGWGAMEDEKRAEVLDVELSALDERDVGFTAHLLHHTLVADGHRADHGPIHDAKNMCFVDPDGSLRDHHGLFNDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1X9</accession>
    <name>R4W1X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02671">
        <property type="protein sequence ID" value="AGN02671"/>
        <property type="gene ID" value="L593_13660"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2795"/>
    <dbReference type="eggNOG" id="arCOG13593">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396213_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009870">
        <property type="entry name" value="DUF1424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07232">
        <property type="entry name" value="DUF1424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="695" mass="79266" checksum="D9E106B89EE965BC" modified="2013-07-24" version="1">MPEPGDVSERFWNEFPEMARMPLSHQHERGLRPELLDRDTSEEFVEPMVEDLPDGANLDSLDDKPEDWTSGFDVEQEDGRNPVMWGEAVVRLLQSHEDCRNTTLHLERGYPGDPGHATHDVEADNRWMPSYQKKKFAEMNGWFREVVGVGERPSGESPDGIMEHPNVVLLTRSASSRPGKYKLGPVDHADQLRDSWTAVYHKMRNHFRSLGVEWQYDKRVEPHPGDGENQCYPHEHIVLLIDSPDLQLSDLRPIVEEHVETCDAAGPVAHDLDVEDWDANREDVGTAEIRKPDEIDNLAAYVCDYASIEPADLLERELPYVAFAASMWAVNAQTISRSDAACRASTADACKQRFEHSQCDQDLDHGEEIRRKEIRQQRKLVCAECGSPHGIDQSQTLVEAKHGTDDGPTAVADGGRDWHEEREDSLRDRWPSADAAVAVGEQPTRTGREIRNPDDSDKGKAITDRDIRLLVRGLGEGVRRPEWMKDGWILEHDPRYRPDPDDPLVYSAWSRAPDLRDPLPRIVVFLQERYSLHPDRIAEFVHQERADYDPQEDMVSFRRPPAWRLDAITVHGERHSVDDGGGGVQLVETRLSGEALKDWIRRNTRILEMAADTCGQLLWKGSHTRVSDVVDRLAERAGASVDRCEHIIEAFVDVPHRPIPWWEPECWGCSDGEYEGDRETSTWECWNCGDQYPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2I6</accession>
    <name>R4W2I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447800.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14860"/>
    <dbReference type="EnsemblBacteria" id="AGN02906">
        <property type="protein sequence ID" value="AGN02906"/>
        <property type="gene ID" value="L593_14860"/>
    </dbReference>
    <dbReference type="GeneID" id="16181534"/>
    <dbReference type="KEGG" id="sali:L593_14860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3035"/>
    <dbReference type="eggNOG" id="arCOG00910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074702_1_0_2"/>
    <dbReference type="OrthoDB" id="119044at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22658" checksum="4B919E8EA710BA8C" modified="2013-07-24" version="1">MSTRRSLAQRLGVVAGFDDPRVDLEQYPTPPELAAYLVHVADLQGDLADRTVVDLGAGTGMLALAAALRGAGLVVGVELDRDPLETAVQNERKVATTTDIDWVQGDATRSPLATDRSRTTVLMNPPFGAQHGNRGADKAFLETARSIASVSYSVHNEGSQEFVEAFAADVGGEVTHAYEAEFELDNQFVFHEDEQRILDAEVFRIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Y6</accession>
    <name>R4W2Y6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name evidence="2" type="ORF">L593_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445096.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01245"/>
    <dbReference type="EnsemblBacteria" id="AGN00202">
        <property type="protein sequence ID" value="AGN00202"/>
        <property type="gene ID" value="L593_01245"/>
    </dbReference>
    <dbReference type="GeneID" id="16182800"/>
    <dbReference type="KEGG" id="sali:L593_01245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.253"/>
    <dbReference type="eggNOG" id="arCOG02097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064444_1_0_2"/>
    <dbReference type="OrthoDB" id="75928at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="229" mass="24512" checksum="82EE916F0E919663" modified="2013-07-24" version="1">MDFSEFVLTASTADLSDATHPAAREHADAVEFRMDLAADPLSLLDAYDGALPILATNRVEWEGGQAPDDESRLDDLVRAAEYDAVEAIDVELEAMRRGGATSVPDRVGDDVTIVASVHDFDRTPSMDDLRSLARQTTEYGDVGKVVPTAESVDDVPPLLTVTREFCAQGRPIATMAMGEPGRHSRAVAPLYGSRIGYAPVDPNDATAPGQYDVATLAELVARLEAKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3F1</accession>
    <name>R4W3F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/lipoate A/B protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445386.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02705"/>
    <dbReference type="EnsemblBacteria" id="AGN00492">
        <property type="protein sequence ID" value="AGN00492"/>
        <property type="gene ID" value="L593_02705"/>
    </dbReference>
    <dbReference type="GeneID" id="16180310"/>
    <dbReference type="KEGG" id="sali:L593_02705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.548"/>
    <dbReference type="eggNOG" id="arCOG01941">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085363_1_0_2"/>
    <dbReference type="OrthoDB" id="74194at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="227" mass="23912" checksum="0DB8EBD4E0D691B4" modified="2013-07-24" version="1">MRVVRGSGDTIEADRALTADLRAHAAETGEQGVRVWLPERQVAFGRRDVGAPGYDRARRLAQEKGYTPVGRTVGGRAVAYHGSTVAFARVEPVEDPRTGLQDRYERATDAVARALETVGIETASAGEPDDTFCPGSHSLSVGGGKVVGIAQRVTTESALVAGVAIPRDRWPLAEVLEAVYDALDVPFDPETVGSVRSAGGDGDPDALVAAIEDELVGDAEPEIVEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3J4</accession>
    <name>R4W3J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03080"/>
    <dbReference type="EnsemblBacteria" id="AGN00567">
        <property type="protein sequence ID" value="AGN00567"/>
        <property type="gene ID" value="L593_03080"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.623"/>
    <dbReference type="eggNOG" id="arCOG00609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="7">
        <location>
            <begin position="184"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="7">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="46362" checksum="6E1F0E6604192BBF" modified="2013-07-24" version="1">MPSEDPGRGVGPRDRDGRDGTERDREPSDRRDRSERQSRWGAASANGGTADLGPGSLDAEQPGGPGTDANRPPPPSAIDHAFHVTEVRTEGDRVYYFGHALVGDDLEAAITPAFRNAGYAISHVERAGEDVVVARPAASGVDGVPWTHLLLFVLTIGSTLIAGSMWFFVNPIQEPTQIWKGWPFSVGIMTVLGVHEMGHYVMTRRHDVDATLPYFIPVPTLIGTMGAVIRMKGSMPDRKALFDIGVAGPIAGLIATVAVTVVGLYLDPVTAPAELATSENAQEIAIGFPPLLHFLSWLTGQPLYYDDPLTTVHPVVVAGWVGMFVTFLNLIPVGQLDGGHVVRAIAPEYQATIAAVVPGVLYALAGYLLLVRDLAPRNVTLWIVWGTIALALAFVGPATPTDDSTDIGWKRTVVGIATFVVGMTCFAPVPIAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3V5</accession>
    <name>R4W3V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445636.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03955"/>
    <dbReference type="EnsemblBacteria" id="AGN00742">
        <property type="protein sequence ID" value="AGN00742"/>
        <property type="gene ID" value="L593_03955"/>
    </dbReference>
    <dbReference type="GeneID" id="16180739"/>
    <dbReference type="KEGG" id="sali:L593_03955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.804"/>
    <dbReference type="eggNOG" id="arCOG04738">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074280_0_0_2"/>
    <dbReference type="OrthoDB" id="25620at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043953">
        <property type="entry name" value="DUF5784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19096">
        <property type="entry name" value="DUF5784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="330" mass="37395" checksum="710802CD2926D7EE" modified="2013-07-24" version="1">MASPLRFRYDPAGWSDKRVRRELYASLDDYAGVTWVEPEHDLHGWEAARFELDNGDLALFVWRDGEAYWLGNTETPSALWRTNKHGWEEVPFELARWARKELLVDLYDRAPWLENYEYLTWFFLPVLMSKDGTETALKFFKEHAAGFPNASREAGLEFYDEFLKSGVFEDDRETMAGKLGTSGRLDLTRMRAAMGEFTVGKVLHDAGYVFEPEIELGSGYALDYRVDDTLVEVARPQPPAKRSNANTPIAAVKETARSKGRGQLDTHAGALLVVDCTSFPDDAWRSLRAEQPNLPYQPTLVIRARPEGRIEGFEVGKVPIDVADAVDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3X0</accession>
    <name>R4W3X0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445666.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04105"/>
    <dbReference type="EnsemblBacteria" id="AGN00772">
        <property type="protein sequence ID" value="AGN00772"/>
        <property type="gene ID" value="L593_04105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180063"/>
    <dbReference type="KEGG" id="sali:L593_04105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.834"/>
    <dbReference type="eggNOG" id="arCOG07840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_2_1_2"/>
    <dbReference type="OrthoDB" id="15793at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="154"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="248"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="525" mass="54775" checksum="3FF3AFDADA5CBBA3" modified="2013-07-24" version="1">MNETRRSILRKASALSALALGASATASAADCSGVPAWDPDTAYNGGDQVTYDGTLYTAEWWTRGSTPDDSKSVWTAEGSCDGDGGGGGGGGGGGGDGASCDGVSVWESDVAYTGGDQVVHDGKLWTAEWWTRGTEPAESENVWTLEGNCGNFSPTAVASATPTNPAVGATVEFDGSGSSDQDGTISSYSWAFGNGASATGQTASHSYGSKGDYTATLTVTDDAGATDTDSITISVGDDGGGGGGSKEDDVFAPYQGTWGDVPNATLNANTDRVVLSFVGDATDGDGVNPGWLTSGGQRPLSDFAGEIQTLQDNGVEVWVAIGGWDGRTVARDATDATVLKDAYAEILDTLGVTHLDIDDENANEAGRDGSVYRIRNEALAMLQDERPEVKISYTVPAGSGGIENRNYSPAKDMVADAVAQGVDLSYVNVMTMGYSGDYTSFISGAAQGTVDWLANPFPNKTEAERWEMLGVTPNVGESNFTESDGQWLVDYAEQHDMGLLSFWAMYKSSANAQADIFYQFEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W488</accession>
    <name>R4W488_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445876.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05165"/>
    <dbReference type="EnsemblBacteria" id="AGN00982">
        <property type="protein sequence ID" value="AGN00982"/>
        <property type="gene ID" value="L593_05165"/>
    </dbReference>
    <dbReference type="GeneID" id="16181245"/>
    <dbReference type="KEGG" id="sali:L593_05165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1054"/>
    <dbReference type="eggNOG" id="arCOG01078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_14_4_2"/>
    <dbReference type="OrthoDB" id="91733at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="Ap4A_hydrolase_human_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="16811" checksum="D974F2900AF46418" modified="2013-07-24" version="1">MPVEATSAGAILYRDTRGRREYLLLKSRPGDWEFPKGGVEGAEELQQTAIREVEEEAGIEDFRLLDGFRDEYDYVFEANGNTIHKTVHLFVAKSFEASAELSHEHRDHQWRDYEQAINTITQDGPREILEDAHEFIDELEAEAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4C5</accession>
    <name>R4W4C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445941.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05490"/>
    <dbReference type="EnsemblBacteria" id="AGN01047">
        <property type="protein sequence ID" value="AGN01047"/>
        <property type="gene ID" value="L593_05490"/>
    </dbReference>
    <dbReference type="GeneID" id="16180650"/>
    <dbReference type="KEGG" id="sali:L593_05490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1121"/>
    <dbReference type="eggNOG" id="arCOG09020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040292_1_0_2"/>
    <dbReference type="OrthoDB" id="37102at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="321" mass="35516" checksum="EC63B211A1034C57" modified="2013-07-24" version="1">MPEDAPTKVAIACQGGGSHTAFTAGVLKGVLREWEDEYELVGISGTSGGAFNALATWYGLVTDGEERAIELLDALWDDLAADDLTDRMANDWGVALSRIEASGLPLPRVSPYLTPGSRLGKSRIRRILERHIDFEAVPDHCTREAPELVVGTVDVNAGVFETFTNEDVTPEAVLASAAVPTLFEAVEIHGHYHWDGLFSQNPPIDDLMTGDAARKPEELWVIQINPQEREGEPTSLEEIADRRNELAGNISLNQELRVIERVNDWIDAGHLPESDFSKTRIRRIAMDRAYHCSTKVDRSPSFLQELQDLGETRAQTFLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4R9</accession>
    <name>R4W4R9_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06750"/>
    <dbReference type="EnsemblBacteria" id="AGN01297">
        <property type="protein sequence ID" value="AGN01297"/>
        <property type="gene ID" value="L593_06750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1379"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838388_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="371" mass="41728" checksum="1A506D2D08049123" modified="2013-07-24" version="1">MSNDSSAPTDTDERGSSSPRSTSSREDPDDDQPGERIGDVVERIRARREEAEERGKGQSDGVIADQLEVVEDRLLSFARELGGEIDEVADLPFTEEAAQDEMPSALYVRHDEILLNQVTSWLLQDQHIGLVSPYGTGKTAFREVVLRDLGDHDDFVVAHVENPRDTTPRQLYGEVLEAAYDAGFELDTAQFTQARDGIPWATDEARQAVRQMTEEIREEGKRPILLVDEIEVLPAELLSPLQTAGDAGVRLFLLGTPEGKERVANLRGTLDSRLRYYEGIEPFDADAVEEYVERSLAFMRGEGYDGQPQSLFTREAIEDIAERSEGNAREVRIECRELFTRAAFVWDKTGQSIDRIQITPQLRHRRFGMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Z9</accession>
    <name>R4W4Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446326.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07435"/>
    <dbReference type="EnsemblBacteria" id="AGN01432">
        <property type="protein sequence ID" value="AGN01432"/>
        <property type="gene ID" value="L593_07435"/>
    </dbReference>
    <dbReference type="GeneID" id="16182130"/>
    <dbReference type="KEGG" id="sali:L593_07435"/>
    <dbReference type="eggNOG" id="arCOG09394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961780_0_0_2"/>
    <dbReference type="OrthoDB" id="98363at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="29754" checksum="1C0EFEEE6B59BF06" modified="2013-07-24" version="1">MVRTISTPGSERSVRRPWWRRLATVAALAIVVVAVAVATTGSAAGAAQADANESTTNESIETTELVPLNLTAAAANDSTAVTISGEGQTVTDPFVLEGGLLLVGYDHAGESNFQLVLWNESADEEVAYLANRIGTVDGVGATGLPAGEYSMAVTADGPWNLTLLQPNATATASAAPANATDGGATTTDGRSNATPVYPNATEAPATASGEGQAVLGPVNFTESVILTANHTGESNFQVTIWSENATSFLDASYAFNEIGRVDGAETRLRHTGTAWIVVNADGAWELSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W573</accession>
    <name>R4W573_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08060"/>
    <dbReference type="EnsemblBacteria" id="AGN01557">
        <property type="protein sequence ID" value="AGN01557"/>
        <property type="gene ID" value="L593_08060"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1652"/>
    <dbReference type="eggNOG" id="ENOG502N5FM">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425552_0_0_2"/>
    <dbReference type="OrthoDB" id="85257at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="643" mass="66678" checksum="A0AE059467B4B000" modified="2013-07-24" version="1">MPAADPRRWQEVASMPSSPRRRALLKGIGSAGAAGLLAGCSGVLSGGGGGDGSPNNSSSGSGSGTGGQGGSGGTAHTADVQVPTCTDPETLTRDDLNGGATISAGCYRVDSNHEIDSGQLTLESGVVIEFAADAGLKFTGGTLLTTGTPADPVFLVGETAQRGFWQGLRFEGSTADTNLLESAVIAHAGSELWHGGDISRAGLFVRDSIIELNNSTIRNHRRSGLTVPDGAVDLSVSNTVFEANERPARLHPDLVGDFEPSNVVRDNDDDRVKAAGTGSGDTITTDQIWQSPGVPFYVTKNLTTEAYLTVDPGTTIEFKAGKGLDVNGGTLRAPGTAEDPITVRGEESGRGTWQGLRFVNTVSADNLLEHVVVDGAGDSLWHGADRSKAGVYAQNADVQVTIRNCTFERNAVTALTADGGGEDGADLTVEGCSFRDNAVPMRLSADLVDGVAASQSFEGNDGSYVLVGATGSSTRVTADATWAALDVPYRLTRHCRCHAGLTIEPGTTVEAAAKKGIYVPEGYLTADASGADPITFTDAADAEENWRGISVNTAASENRLDDVVVENAGNGLWTGNWDSHASIFVYGGEDNGELRIRNSTIRNSAGHGIAKADSGVLSCGNLQFENVADSDVYEMYTGAINPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5L5</accession>
    <name>R4W5L5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">L593_09285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446696.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09285"/>
    <dbReference type="EnsemblBacteria" id="AGN01802">
        <property type="protein sequence ID" value="AGN01802"/>
        <property type="gene ID" value="L593_09285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182668"/>
    <dbReference type="KEGG" id="sali:L593_09285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1907"/>
    <dbReference type="eggNOG" id="arCOG01711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_2"/>
    <dbReference type="OrthoDB" id="103587at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="181" mass="20839" checksum="D1C8B45ACB89DDB5" modified="2013-07-24" version="1">MVNLWEDLETGPNPPEEIYAVVECLKGERNKYEYDKDVPGVVLDRVLHSNVHYPSDYGFLPRSYYDDEDPFDVLVLVEDQTFPGCVIEARPVALMGMDDDGEQDDKVIAVPTEDPRYDHVQDVEDLTDQQKAEIAEFFETYKNLEEGKEVETLGWEDADAAKDAIEHSMELYDEHFDSPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5M2</accession>
    <name>R4W5M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446711.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09360"/>
    <dbReference type="EnsemblBacteria" id="AGN01817">
        <property type="protein sequence ID" value="AGN01817"/>
        <property type="gene ID" value="L593_09360"/>
    </dbReference>
    <dbReference type="GeneID" id="16182842"/>
    <dbReference type="KEGG" id="sali:L593_09360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1925"/>
    <dbReference type="eggNOG" id="arCOG07766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870829_0_0_2"/>
    <dbReference type="OrthoDB" id="83491at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="15584" checksum="CE4A3686AFDF2D05" modified="2013-07-24" version="1">MPNSPVGFDLQYVVSPPDERCRVWIGIDVFRGDVQRFLVQLQRRSAAERRTVVQIARIDHNPAGRDGHDLRTEGVHVDVVLRDGDEQTVYPPTNPGVQTDLGATIDQAKRYFRRHTGYFLRVHYGEIEPNDPPPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Q2</accession>
    <name>R4W5Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446771.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01877">
        <property type="protein sequence ID" value="AGN01877"/>
        <property type="gene ID" value="L593_09660"/>
    </dbReference>
    <dbReference type="GeneID" id="16182577"/>
    <dbReference type="KEGG" id="sali:L593_09660"/>
    <dbReference type="eggNOG" id="arCOG02085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673701_0_0_2"/>
    <dbReference type="OrthoDB" id="58580at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="413" mass="42253" checksum="C75BA900F517FCB3" modified="2013-07-24" version="1">MTRTMLVAAAVALVVLAGVGGTAIADAGAAQDDVVTIELSVTTPQGEAIGNAEATIEWDGGSTNATTTSNGRAFADVPNGADLAITLAHEEYVKNVPHTVSGAASGQVVETTMYQPATGEIEVVDSDGPVEDATVRFRKQGQSSFAARGDTGSSGVFASPEIEAGTYTVIVREPGYYDASQTVQLDGASNATVQIEQGEVTIDLLTQDPTPEGPGLVSADVDVTQDGDRVVSVTTNDDGHRSVVLDVNRDYDVTVSKEGYLELTTSLQTGESDAQATFNVTRVPSISLTAGNERVVVGENLRVEVTDEYDRPVEGATVFVGGEQAGQTDANGVARVEIPSEGDVEVSAEFEDRTTDPANVTGVEPSSSDDGGASDDGGNESDDGGTGNGSPGFGLVAGLLGALAAVAALARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W0</accession>
    <name>R4W5W0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Copper-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_00340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444917.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00023">
        <property type="protein sequence ID" value="AGN00023"/>
        <property type="gene ID" value="L593_00340"/>
    </dbReference>
    <dbReference type="GeneID" id="16181938"/>
    <dbReference type="KEGG" id="sali:L593_00340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.68"/>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_2"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="883" mass="91959" checksum="6FC6F07E9A2D1F41" modified="2013-07-24" version="1">MTTRTAQLSIQGMSCANCAQTITDTVEDLDGVETASVNYATDEASVEYDPDSVSLSAIYDAVERAGYDPVRVDRSIAIADMSCANCADTNEDALGAVPGVIDVDVNYATDEASVSYNPNDADLADLYDAVENAGYSPVREGTDGGESGGGSEGDSGGDGEEVSARDAAREAEIRKQLRLTLFGAALAAPLVFFLIERLVIGGGILPDHVFGVEFGWLEFALATPVQVVLGKPFYENSYKALVRNGRANMDVLIALGSTTAYLYSVVVLLGLIAGGLYFDTAALILVFITLGNYLEARSKGQASDALRELLEMEADTAIVVRDDGSEEEIPLEDVQVGDRMKVRPGEQIPTDGRVVEGSSAVDESMVTGESVPVEKSDGDEVVGSTINEGGLLVVEATKVGEDTALQQIVQTVKEAQSRQPEIQNLADRISAYFVPAVIANALFWGVVWFLAPDALAGAVDALPVWGLVGGGPGTLGAFEFSVIVFASAVLIACPCALGLATPAATMVGSTLGAKNGVLFKGGDVLERAKDVDTVVFDKTGTLTTGEMQLTDVVAVGDGAVSADGGSSSGEPAADGGAVSEVEPPTLDEDEVLRLAASAEQGSEHPLGEAIVDGTRERGLDLSDPEEFESVAGRGVKATIDGRAVAVGNRRLMAEEGVDASAAEDTMERLESEGKTAMYVAVDGSLAGAVADSDTLKESAPDAVAALQARDLDVMLITGDNERTARAVAEQVGIDPGNVRAEVLPEDKSDAVEAIQSDGRKAMMVGDGVNDAPALAVAHVGTAIGSGTDVAIEAADVTLMRDDPLDVVKAIRISEATLQKIKQNLVWALGYNTAMIPLASLGLLQPAFAAGAMAISSVSVLSNSLLFRRYVPDHDYRLLGFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W641</accession>
    <name>R4W641_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10760"/>
    <dbReference type="EnsemblBacteria" id="AGN02097">
        <property type="protein sequence ID" value="AGN02097"/>
        <property type="gene ID" value="L593_10760"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10760"/>
    <dbReference type="eggNOG" id="arCOG03020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646076_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="76" mass="8305" checksum="5820A124BCF4DF98" modified="2013-07-24" version="1">MDREITPETLQGTLEELSYPALRPDAAAELKDVTVDFGDETLNLGAMISETGPDSYKTPEELKAAIEERIPDAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A2</accession>
    <name>R4W6A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid binding OB-fold tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445132.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01425"/>
    <dbReference type="EnsemblBacteria" id="AGN00238">
        <property type="protein sequence ID" value="AGN00238"/>
        <property type="gene ID" value="L593_01425"/>
    </dbReference>
    <dbReference type="GeneID" id="16180071"/>
    <dbReference type="KEGG" id="sali:L593_01425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.290"/>
    <dbReference type="eggNOG" id="arCOG00429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018957_1_0_2"/>
    <dbReference type="OrthoDB" id="1910at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="737" mass="77294" checksum="11B4DFEB3DD5889B" modified="2013-07-24" version="1">MGSCIICGTTVDGEVCDVHQEDVGFVFEGTSPNELTPNRYYRGTVDGYADFGVFVDIGDSVTGLLHQSELDQRLESLSWEPGDEVFVQVTGVRDNGNVDLAWSIRQDEREFRGLLVDSPDGERRHESAEDSNAGPDAATSGGESSGNEDVRQRQSDGGKTPSPARDASSGGADGSEDDEQSSSVAEPASDTESVTDTEQSDAAVTAETTSSGGDGATATTSAATSATSATSSDASAEPESMDVGDLEDAVGEFVRLEGEVTSIHQTGGPTIIELRDGAGTVDCAAFDGAGVRAYPEVDVGDVVRIDGTVERRRGDIQVETETLETLVDDEASAITERVAAAMADAVRPDDAQFVADDDPAAPLADGIVEAATAVRQALAEERPVVLRHPATADGYAAGAAIERGAFARARTDAGGAEPDYHVVHRRPLDDPLYGMDAATSDLTRMLQDRERHGEQLPLIVLVGVGSSVEAQEAVELLDVYGVDRIVLDSAQPDEGVERVGDVVVNPHLAGVDVDLSNAALGAALGATVGPAATQDLAHVPAVGYWEDVPEAYSAAATDAGYTHEELRAIREALALEAHYQRYNDKRELVADLLFDGAIDLAEHVAGQFREKLDTEVATARDNLVVRETGGVRFAVLDTDAFTHRFDFPPTALLVDELHRRERDAAAGAVVTIGAGEDELLVRSTESVDVREIASAADDSAPAIEAVGGADGHIEYLPGDRDAAIEAVVGVLASSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E7</accession>
    <name>R4W6E7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="L593_11595"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11595"/>
    <dbReference type="eggNOG" id="arCOG08928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159738_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="98" mass="11106" checksum="0B61CE27A86E61BE" modified="2013-07-24" version="1">MFEIDTERMDSDTDDQIVHRGLDTDVEEPAVRISEHVGDLEDRDPTSLATMHDCVDGVLDHIFSTPPSPEAQIEITFSYEGYRITVEQNGHARFVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U1</accession>
    <name>R4W6U1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase</fullName>
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        <name evidence="2" type="ORF">L593_03110</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03110"/>
    <dbReference type="EnsemblBacteria" id="AGN00573">
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        <property type="gene ID" value="L593_03110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180436"/>
    <dbReference type="KEGG" id="sali:L593_03110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.629"/>
    <dbReference type="eggNOG" id="arCOG06256">
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    <dbReference type="OrthoDB" id="64420at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23045" checksum="910240E7DB785C7C" modified="2013-07-24" version="1">MSDPHGEATVVTAGAALEDASAAVVAMHGRGATARSVVDLVEQAAARRDVSDLAIRAPQAHRNTWYPNSFLAPIDANEPHLSSALGLVERTVAEAAEAVGREQVVLLGFSQGGCLASEFVARNPARYGGLVALSGGRIGPEGIEWDEEATLATAERDLEGTPAFLGCSDVDPHIPAERVHETAESLEALGGDVTVELYPGMGHTVNEDELEGVAGMLASATPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6V2</accession>
    <name>R4W6V2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN00588">
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        <property type="gene ID" value="L593_03185"/>
    </dbReference>
    <dbReference type="GeneID" id="16180342"/>
    <dbReference type="KEGG" id="sali:L593_03185"/>
    <dbReference type="HOGENOM" id="CLU_208836_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6252" checksum="37F8DE9D47D89E33" modified="2013-07-24" version="1">MERSIESIVAGGLALLAGLWTLEAAQFVGRWHLAGGVVAVLGLLAIGAGIARDLHYGPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X0</accession>
    <name>R4W6X0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02567">
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    </dbReference>
    <dbReference type="GeneID" id="16181726"/>
    <dbReference type="KEGG" id="sali:L593_13140"/>
    <dbReference type="HOGENOM" id="CLU_989082_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="281" mass="32568" checksum="9FE37AA5A555892B" modified="2013-07-24" version="1">MDLEKIEDVLGEEFRIAHEEKTKESWTLEESLSKDWTDKEKLPDEDSDFDQWTVPQTLAVHNPIIEIIDAIRREYNIRSEAHAVKRGLRYGLTILSEEWEDTISQLSRNRIVAGEVSGYIPRGGMYDRFNETDILAVDWGRKVDRKSWRIIWNQKGFIKYLSEALGVDEADIVRWSMIIVGDGLGQRETIGPALQDRIQDILDEIEYRVKDIAANRRSIRRAMIADALTGRYSQDAAGLLQEKYPDVWREFRPNADRLQKQLPDSRDPSLEGTTGFLDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W704</accession>
    <name>R4W704_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03585"/>
    <dbReference type="EnsemblBacteria" id="AGN00668">
        <property type="protein sequence ID" value="AGN00668"/>
        <property type="gene ID" value="L593_03585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180606"/>
    <dbReference type="KEGG" id="sali:L593_03585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.728"/>
    <dbReference type="eggNOG" id="arCOG01238">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_033807_1_0_2"/>
    <dbReference type="OrthoDB" id="10440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01660">
        <property type="entry name" value="ba3-like_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033943">
        <property type="entry name" value="Ba3-like_Oxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="565" mass="62025" checksum="10198CDEEB9875DA" modified="2013-07-24" version="1">MTYVDEFPTEAKIVRWHWGVAFIALGLGGAFGLIQALFRTGYFRDALPITAQEYYTVLTGHGVLLALVFTTFFICGMFVWALTRSFDRELHDARIVWTGFLSMLIGTVLATIAILNGFAPGLPFGSSDVLYTFYSPMKAHPAFYVGAALLIVGSWIVGADYFLTFREWRADNPGARIPLQAFMVLTTWIMWYLATLGVAVEVVFFLIPWSFGWIETVDPLLTRSLFWFFGHPVVYFWLLPGYVAWYTILPKLAGGRLLSDPLARVVFVLFVLLSTPVGFHHQYVDPGIAEGFKTIAMTNTMMLLLPSFLTAFTVVASMEYGARRNGGKGFLKWLRSLPWGDPAFAGMALAGLMFAAGGFSGMINAGMNINYLIHNTLWVPGHFHLTVGTAFALTAMATTYWLYPQLTGKRLQHRTLALIQPYLWFIGMTLMSNAMHRGGLAGLPRRTAEPLANASGADAFAPVFGTIAEIQFQIALGATLLTTSLALFLVVVTGTWLSRPREGALRVNGDLPEALSGPEDSPRVLDNLTLWAAIAVLLVLIAYGVPLWSMVADGLLSPGSAPVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W709</accession>
    <name>R4W709_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447521.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13440"/>
    <dbReference type="EnsemblBacteria" id="AGN02627">
        <property type="protein sequence ID" value="AGN02627"/>
        <property type="gene ID" value="L593_13440"/>
    </dbReference>
    <dbReference type="GeneID" id="16180623"/>
    <dbReference type="KEGG" id="sali:L593_13440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2749"/>
    <dbReference type="HOGENOM" id="CLU_2857259_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6535" checksum="985F1FACDBD9EEB7" modified="2013-07-24" version="1">MSEKPAGKGRSVNPLRFAAIGLVAGLAGAITATTVAPDSLVVTILLIVVVIVVVTLLLLRVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W747</accession>
    <name>R4W747_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">L593_13765</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AGN02692"/>
        <property type="gene ID" value="L593_13765"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2816"/>
    <dbReference type="eggNOG" id="arCOG08121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157707_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023906">
        <property type="entry name" value="rSAM_target_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03995">
        <property type="entry name" value="target_X_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10573" checksum="97B81729CD13829B" modified="2013-07-24" version="1">MQDPVTDERHDNSWSANLEKPEHADDPDVVVAGAKRAVEYTLPGNHVNLVTHGDHGHPEEYLYDVLRDTFGQQIAVDYVEQCGCGGHVSRVHVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W777</accession>
    <name>R4W777_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide binding protein PINc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447611.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13890"/>
    <dbReference type="EnsemblBacteria" id="AGN02717">
        <property type="protein sequence ID" value="AGN02717"/>
        <property type="gene ID" value="L593_13890"/>
    </dbReference>
    <dbReference type="GeneID" id="16181680"/>
    <dbReference type="KEGG" id="sali:L593_13890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2842"/>
    <dbReference type="eggNOG" id="arCOG04312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107892_2_0_2"/>
    <dbReference type="OrthoDB" id="118267at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_9" evidence="1">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14600" checksum="92651C8E91A59D8F" modified="2013-07-24" version="1">MTRTVAIDTNALMMPVELDVRLFEELDRVLGGASADGGRAGFEPIVPQAVIEELRRLSEGGGGEEAIAASVGYDLATERCMPVDTETAVADDAIVELAREGTADYVVTNDLPLRDRVLDAGVSVLSLRGTDKLAVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F2</accession>
    <name>R4W7F2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447771.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14715"/>
    <dbReference type="EnsemblBacteria" id="AGN02877">
        <property type="protein sequence ID" value="AGN02877"/>
        <property type="gene ID" value="L593_14715"/>
    </dbReference>
    <dbReference type="GeneID" id="16181437"/>
    <dbReference type="KEGG" id="sali:L593_14715"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_2"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="29871" checksum="5E41E2B72006EEB5" modified="2013-07-24" version="1">MPDWVSTFGAKSDRTVVLLHPAGWTRHAWTPHAERLADRYCVVTIDLPGHGVHPAPEFSMERAVADVDRVLDSFGTAALVGHSLGGYVAIRAAAGDPERVDGLLLAGAAYNWYWRSPVGLALSVAQRLQSSLFEGLSHFPRLARRFKHVPDDETQLPPPHEDTHPYWTGFVSAIRDITFRQSWQDVEAYGGPTLIIHGDTELLAGQAGALAARAKANLRWIEGDHYAPMDDAETFTAEVARFLDDVYAVQMEASASENRSHRVRDLLRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H7</accession>
    <name>R4W7H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase or acyltransferase of alpha/beta superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445867.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05120"/>
    <dbReference type="EnsemblBacteria" id="AGN00973">
        <property type="protein sequence ID" value="AGN00973"/>
        <property type="gene ID" value="L593_05120"/>
    </dbReference>
    <dbReference type="GeneID" id="16181213"/>
    <dbReference type="KEGG" id="sali:L593_05120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1044"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_2"/>
    <dbReference type="OrthoDB" id="30817at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="28161" checksum="6157ECBB47D21771" modified="2013-07-24" version="1">METVSHYGRTTAYRESDRGGSGSPLLFVHGSGGSHAVWRSQFRLADDHPITTLDLSGHGESDDVDANAGYETLSAYADDVIAVADATDARILAGNSLGGAVALHVALERTDEIDLDGLILAGTGARLAVLESLREWLAEDFDRAIEFLHAPGRLFVDPSPELVDASETVMRETGRAVTERDFLTCHEFDVRDRLDEIDVPTLAIAGGGDQLTPPRYHDYLASEIPDAALAILENAGHLAMLEQPEAFNTAIYRFVTDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R8</accession>
    <name>R4W7R8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADH_zinc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446042.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05995"/>
    <dbReference type="EnsemblBacteria" id="AGN01148">
        <property type="protein sequence ID" value="AGN01148"/>
        <property type="gene ID" value="L593_05995"/>
    </dbReference>
    <dbReference type="GeneID" id="16179991"/>
    <dbReference type="KEGG" id="sali:L593_05995"/>
    <dbReference type="eggNOG" id="arCOG01621">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_2"/>
    <dbReference type="OrthoDB" id="51760at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="157"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="36355" checksum="1D7E43446387C39A" modified="2013-07-24" version="1">MNQTVVFPDAREVAVEDRDRPEPSADEVLIETDTSLISAGTECTVLSGDFPEGSFWDDYAEFPFDPGYANVGTIAEVGDDATTGATGEELEVGTRVATWTPHAEYVTAAAGDCVVVPDDVDDEQASLFAIAQIVMNGVRRGRVDWGETVVVYGLGILGQLAVRFARLAGADVVVGVDLADQRLEYLPDAPEVVGVNPTEEDPAEAVERATGGDLADVCFEVTGNPDVIPQEFDVLREQARLVLLSSPHGKTTLDFHDHVNAPSHEIIGAHQLSHAPVATPRDPWTKPAHAELFFSYLEQGRLSVADLFSHVEDAADAPAVYDSLLGDRSDAMAVRLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T8</accession>
    <name>R4W7T8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00059">
        <property type="protein sequence ID" value="AGN00059"/>
        <property type="gene ID" value="L593_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00520"/>
    <dbReference type="eggNOG" id="arCOG03860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067906_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="13104" checksum="4BC925F4CFA534C0" modified="2013-07-24" version="1">MDALEALGNEIRISILRELADAERALSFTELRDRVGLRDSGKFNYHLSTLCEYFVRDTNEGYELGHAGTRVISATGRPAPDEAEDSGVEPIAAEEECPVCGEPNCEKLFHVHLSAPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U2</accession>
    <name>R4W7U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446087.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01193">
        <property type="protein sequence ID" value="AGN01193"/>
        <property type="gene ID" value="L593_06220"/>
    </dbReference>
    <dbReference type="GeneID" id="16181641"/>
    <dbReference type="KEGG" id="sali:L593_06220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1270"/>
    <dbReference type="eggNOG" id="arCOG04474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038446_0_0_2"/>
    <dbReference type="OrthoDB" id="79408at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035185">
        <property type="entry name" value="DUF5305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17231">
        <property type="entry name" value="DUF5305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="458" mass="48368" checksum="1015929476BE5248" modified="2013-07-24" version="1">MIENPRVRLALAEHGRRIALALAILGAVLLVLAIWTVVTPASETVRQPADSQTIETEVSHSAVVQSADSPWEQGTTLQDHPAYLLNASPTLDVAVRTDAPPGSTVVHDARLQLRVVRNGDVVWEETRALAAEEQTATNGTAISTAAIDVERLQAQRRDLQEQFAGVGTVQTRIVADARYETDTYEGTLSATGPLTVTNRAYWIDGDPSDSAARSRTVTVERTAPVDWGTVALFVVLGLLAVGGAAAAATYRVEADIDWLQQEVHRQRYDDWISDGNLPMGVGSEYVALDSLKDVVDVAIDTNQRVVYDDRRNVFAVISGEVVYYYSKDGDWNRVAWPQTQSDDSGPSFLEAFGMGDEDVPGAEATPPGDGGFGGGPDAGDGPGFASGGADAVPADAASDSSADESDDADATDADDAPEAVFGTDEDAADPPDDAGGDGSVGPAERPPEDRPFGGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W813</accession>
    <name>R4W813_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01413">
        <property type="protein sequence ID" value="AGN01413"/>
        <property type="gene ID" value="L593_07340"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07340"/>
    <dbReference type="eggNOG" id="arCOG08931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172269_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8967" checksum="27C3F85B047DE710" modified="2013-07-24" version="1">MHTFTETDEGKRVVNASGDKIGVVSGVRNDNVYVDADPSISDRIRATLGWEHVDEDDYVLDQDKINTVTEDEIRLKRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W825</accession>
    <name>R4W825_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445138.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01455"/>
    <dbReference type="EnsemblBacteria" id="AGN00244">
        <property type="protein sequence ID" value="AGN00244"/>
        <property type="gene ID" value="L593_01455"/>
    </dbReference>
    <dbReference type="GeneID" id="16179812"/>
    <dbReference type="KEGG" id="sali:L593_01455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.296"/>
    <dbReference type="eggNOG" id="arCOG04619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024617_0_0_2"/>
    <dbReference type="OrthoDB" id="15755at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="528" mass="57942" checksum="BA0488D487C3EBDF" modified="2013-07-24" version="1">MKLHPLSVPYRAARTVGNLIVVLIFAFFGIPQFLDGALAVAVTGVLIILGLVAIVGWQYAYYRRFEYTLTDNTLDIDAGVLSRRSREIPYGRIQNVSIERTIVQRALGLAEVRVETAGGSQSEAHLQFVGKAEADRLQDELSERKQHSREQRAAETGTQASVAEAEARPADRRELLFEMTSRELVVLGIVSLDSRILPLVFFALTPFLSEIGELLGGSAGVAVLVLPAIVLAIYLATAVVSAAYAVTNYYGFRLYEIGDELRYERGLLQRFSGTIPLPKVQAVTITENVLARRFGYASLTAETAGFSPGQEGGSEAAIPIARRDRVVDLAESIEPVELPTFERPPKRARTRYVARYSIVLGILTAVSYGAVAAGWWGGQWWLVLLAAPFVPVAAHLKWRNLGYALTDDHVVTRNGFWSRTTKIVPYHRVQTVADTQTIFQRRRALATLHVDVAGSRSLVSDDSKALDVDREVAAELRETIASRLLDDLAERADRPEDRFRDAPIEPVEETAPSGGPSNESATGGSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R4W828</accession>
    <name>R4W828_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07515"/>
    <dbReference type="EnsemblBacteria" id="AGN01448">
        <property type="protein sequence ID" value="AGN01448"/>
        <property type="gene ID" value="L593_07515"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1539"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="108"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="7">
        <location>
            <begin position="414"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="518" mass="57710" checksum="C2204F8C5BE67805" modified="2013-07-24" version="1">MSDDPDAEPEPLTDVDGSSEFEFDVAQTVLGEHESEAATDGSASDPADDAGSDDPAEEGLFDDLLAGDPIFVSKEVLRPSYTPRDLPHRNEQINKMATILVSALRGDTPSNILIYGKTGTGKTASAKYVSQELERTSQKYEVPCDVEYINCEVTDTQYRVLAQLANQFNDQNRDAIAAQLDDLESLRDRAEADPTVLAESDFDVSSIDDVDDRIEELEADRDDIEEVPMTGWPTDRVYNVFFDAVDYRERVVVIMLDEIDKLVEKSGDDTLYNLSRMNSDLENSRVSIIGISNDLKFTDLLDPRVRSSLGEEEIVFPPYDATQLQDILEHRSEEAFEPDALSDDVIPLCAAFAAQEHGDARRALDLLRTAGELAERDQVEQIEGDHVRKAQEKIELDRVVEVVRTLPMQSKLVLYAIILLEKRGVAAINTGEVYNVYDQLCTEIDADPLTQRRVTDLISELDMLGIVNAVVVSKGRYGRTKEINLSVPREETEAVLTSDSRLGEIEGTQPYVQSRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W838</accession>
    <name>R4W838_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446362.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07615"/>
    <dbReference type="EnsemblBacteria" id="AGN01468">
        <property type="protein sequence ID" value="AGN01468"/>
        <property type="gene ID" value="L593_07615"/>
    </dbReference>
    <dbReference type="GeneID" id="16182163"/>
    <dbReference type="KEGG" id="sali:L593_07615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1560"/>
    <dbReference type="eggNOG" id="arCOG02471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040510_1_0_2"/>
    <dbReference type="OrthoDB" id="82952at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="286" mass="30504" checksum="328B947AFEA2CB0B" modified="2013-07-24" version="1">MTLRNRPLDELVIPDETTVEEHDLVTEGDVVVGGRGTVEFGVRGRNVLAGEGTEFGGDIEAEADCRLDMWSDVAGNVLVGRDAYLGERVHVDGELKVAGDLDIGDDVEIEEGFEANGWIVIRNPMPTIVFLFVYLSQLLRMGEEDAAQELVGNLTESDSMDAEPLVIPRGARVGDETWQTDTPARIGDDCRLHGNVRATEITVGEDNDVFGSLRAKGDVVVGDGTTIHGDLSTRNGTVSLEGDARVLGDVACSDLAVSRGADVDGTMRASGEVKILEGAAMPHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W879</accession>
    <name>R4W879_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446447.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08040"/>
    <dbReference type="EnsemblBacteria" id="AGN01553">
        <property type="protein sequence ID" value="AGN01553"/>
        <property type="gene ID" value="L593_08040"/>
    </dbReference>
    <dbReference type="GeneID" id="62368349"/>
    <dbReference type="KEGG" id="sali:L593_08040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1647"/>
    <dbReference type="eggNOG" id="arCOG08131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061327_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="40788" checksum="55EDEE0A32AF10DF" modified="2013-07-24" version="1">MSTDDSMRSRVPGSRWKLWLLLDANRWAVAGLLLGAIFAALALFVALDPASLGSAIASSDPVETLFQGLLTAIVTGVTLVVTINQLVLSQELGAVGDQRDRMQGSLEFRDDVAVQLEEPVSPPEPSAFLRSLLEATADRARELRAAVADCPDPEARDEIAHYADELIENAATVGDDLEGSQFGTYDVVQAALGFNYSLKIFEGKRLRALYGGGADDEPMPDDEQLPEEDAQSPEEDAQSPDDAQVSGDAAQAVLDERARAALDDVVTLLEQYGPAREHVKTLYFQWALVDLSRAMLYSAVPALVVTIASILTLDNAGSVGGSLFGVANQSWVVLLAVTVSLAPFALLLSYVLRIATVAKRTLSIGPFVLRDRDGTGDVEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B1</accession>
    <name>R4W8B1_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445383.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02690"/>
    <dbReference type="EnsemblBacteria" id="AGN00489">
        <property type="protein sequence ID" value="AGN00489"/>
        <property type="gene ID" value="L593_02690"/>
    </dbReference>
    <dbReference type="GeneID" id="16180303"/>
    <dbReference type="KEGG" id="sali:L593_02690"/>
    <dbReference type="HOGENOM" id="CLU_2857255_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6322" checksum="7B09A7D0DD11FEDC" modified="2013-07-24" version="1">MLRIESRLERALLAVATAAGTLLLLAVGSGEPILSGELLPIAVAVGVAVYAGEGSNCAACSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B3</accession>
    <name>R4W8B3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein L593_02715</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445388.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02715"/>
    <dbReference type="EnsemblBacteria" id="AGN00494">
        <property type="protein sequence ID" value="AGN00494"/>
        <property type="gene ID" value="L593_02715"/>
    </dbReference>
    <dbReference type="GeneID" id="16180313"/>
    <dbReference type="KEGG" id="sali:L593_02715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.550"/>
    <dbReference type="eggNOG" id="arCOG04179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_3_0_2"/>
    <dbReference type="OrthoDB" id="130316at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="13137" checksum="CD792CB655738FA1" modified="2013-07-24" version="1">MSNEEDIDDLREKRLQELQDRAEGQGDQAEAEQARKESAEAQKKAMLRQHLTDGARKRLNTVKMSKPEFGEQVEQQVLALARSGRVQGRIDEDQMKELLSELKPDSKSFNVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C0</accession>
    <name>R4W8C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide peptidase SppA, 36K type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446542.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08515"/>
    <dbReference type="EnsemblBacteria" id="AGN01648">
        <property type="protein sequence ID" value="AGN01648"/>
        <property type="gene ID" value="L593_08515"/>
    </dbReference>
    <dbReference type="GeneID" id="16180791"/>
    <dbReference type="KEGG" id="sali:L593_08515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1743"/>
    <dbReference type="eggNOG" id="arCOG01311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_2_2"/>
    <dbReference type="OrthoDB" id="36138at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="142"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="34980" checksum="501744130F8EE687" modified="2013-07-24" version="1">MNDTLSGLLGFAITMLVAGITAAAGIVLFWYLPASGTELVGILLAVVVTVGGLRLGRSIADDALSPYDVAEVGVEGPIVREDGGSPLPTAPSAADADEIVEQIERADDDGAVDALLLHLNTPGGEVVPSEDVRAAAEAFDGPTVAYTTDLCASGGMWIASGCDELWAREGSIVGSVGVRFSQLRFDEFAEETGINYEGIVSGEYKDAVSAPFKPLEDDEREYLQGLSDAWYEQFVERVADATDLDEQAVRDTEAKVYLGSDAAAVGFVDELGDRDAVEAAVAEDLDTSEVTVERFEPQRSFPRRLQGGAATLAYAFGAGLASVVSGDRPEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D6</accession>
    <name>R4W8D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_08690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446577.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08690"/>
    <dbReference type="EnsemblBacteria" id="AGN01683">
        <property type="protein sequence ID" value="AGN01683"/>
        <property type="gene ID" value="L593_08690"/>
    </dbReference>
    <dbReference type="GeneID" id="16182509"/>
    <dbReference type="KEGG" id="sali:L593_08690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1781"/>
    <dbReference type="eggNOG" id="arCOG02721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="489" mass="53796" checksum="0867E7EF57DB28D0" modified="2013-07-24" version="1">MPEPGALLVAADAAGTTLPVFLDPELASRMQFGWTISVHILFAALSIGLAPFIVYFTYREVYGDAERYTHLREFWLKIFAVGFVMGTVTGIPMSFQFGTNWPRFAEVSGELIGGPLAFEAKMAFFLEAVFLGVLLFGKGRVSDRQYVLSSVLVGVGAWLSGFWILVVNAWMQTPRGYELVQRNGMEVAQLTDPAAAFLNPRFPWMYVHMMNASVIAVALVVAGVSAFFLWRERESDAWLSALRVAVVILLITAPFQAVHGDAYGRHVEETQPQKFAAMEAHYETGSADLHLFAIPKEPSAITDPRADNLWTISLPGLGSYLAAGDFDEPVQGLNEYEENPPVAIVFWSFRFMVGLGFLFIGLALWGGILAWRRSLTDSDRYLQATMLASPLGFAALVTGWYVTEIGRQPWVVQGVLRTENAVSTGLTSGQATATLVGFVVLYVLLIGAFLYVVKLIVETELSRVEGRETDPSVWRRVPILGRVAGGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D8</accession>
    <name>R4W8D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446582.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08715"/>
    <dbReference type="EnsemblBacteria" id="AGN01688">
        <property type="protein sequence ID" value="AGN01688"/>
        <property type="gene ID" value="L593_08715"/>
    </dbReference>
    <dbReference type="GeneID" id="16182769"/>
    <dbReference type="KEGG" id="sali:L593_08715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1786"/>
    <dbReference type="eggNOG" id="arCOG02844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773154_0_0_2"/>
    <dbReference type="OrthoDB" id="100430at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14451" checksum="27E305053FF67CED" modified="2013-07-24" version="1">MPTVEYLNYDVVDDEGWDMYDDDVFAEAADMDLSDEDYGTLDVNEGEYILEAAEAQGYDWPFSCRAGACANCAAIVLEGDIDMDMQQILSDEEVDEKNVRLTCIGSPAADDVKIVYNAKHLDYLQNRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E9</accession>
    <name>R4W8E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08765"/>
    <dbReference type="EnsemblBacteria" id="AGN01698">
        <property type="protein sequence ID" value="AGN01698"/>
        <property type="gene ID" value="L593_08765"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1796"/>
    <dbReference type="eggNOG" id="arCOG02322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="432"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="735" mass="77936" checksum="FFF6C58D766E57C9" modified="2013-07-24" version="1">MLFGVVVLLIGGVGGLIYVQTADALEADAETRMEKTASLQASTLANWVDSTENHASLLSQEESVAAGDTEAMESVLANYAERAPPGVTAVHYVDQTGQVQASSAADAVGRTYDTEWSSSPPADGTTMSNPYEDPGVHHSAVAAVAGTGDDGAVVLVANLTAVSGTLERPSDAHHSHTHVVNEQGTVVLSHHGHSIGEQNMGPADELSVDSMAVRQGLAGQTGYTQMTMDGEAMGMGFTRVEGTDWVLMAHVPTHEAFALQEEISKSLVLLLVVALGGLGAIGVLVGRNTTKSIRELAAGAETIEQGDLEQKLESDRTDEIGQLYDSFDGMRVSLRDSLAETEEARKAAEHRREEVAAMADELEATADELATVAESAAHGDLTEEMDADVDNESMERIASEFNEMTDEIQETVAEIRQFSDRVAAHGEQVTASAEEVEGASKQVSVSVQAIADKTERQHETYDAVKARMEDMTATTEEIASQSDQVAELAQQTATTGEAGQTAAREASGAMSKIDADAERAVEEFDQLRDQLERVEEIAESIGELASQTNMLALNANIEASRTAGSEDDKAGFGAVAQEVKEMASDTRESATEIEDLVEAIREQTEATAAEIESTRSEVASHAETIEEATDALDGVAQYAEQTYDGMDEITTASQTQATSAEEVLAMVEDAAELSESVHEEAGRVAAAAEEQTSALSTVTEEASSLTHETRQLRQHLEAFQIEAEVEPEGVPAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K6</accession>
    <name>R4W8K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-fructose oxidoreductase</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_09740</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="GO" id="GO:0000166">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="35573" checksum="E60FF7827B329DCC" modified="2013-07-24" version="1">MDFGVISTADIGTEDVIPGIQQSDHTVAAIGSRDEQAARTVADDLGIERAYGSYEALLADDGIDAVYNPLPNALHAEWTKRAADHGLHVLCEKPLAVDEAEAAELFEYCDDAGVTLMEAFMYRYHPRTVRAREIVDSELGEVRAATASFTFNMRWPGHEDDFRLDPDLAGGSLMDVGCYAVSAIRGFLGEPERVHAVAADTRDSGVDSQLTGVLEYEDGVSGRVHCGFDTPNVERYRVETVDGWLEARRAFGPKPDESVSLTWSVDGREVTETFDPVDHYTLETEGFAEAIEAGEAPLVDREDSLGNARVLDALMASAERGEPVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K7</accession>
    <name>R4W8K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AGN00699">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01296">
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    <dbReference type="HOGENOM" id="CLU_031864_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="37533" checksum="880A7363BF847952" modified="2013-07-24" version="1">MPVLTVVRAMDEDSDANEYEVVVVGGGPAGMTAALYTTRLGHATALVDRGGGRAAMMQETHNLLGVTEDTSGAEFLNVGREQLDAYGTERHRDLVGTCARTEDGRFRLTGNEGEYVADAVVLATGFNDVRPEPPLPRTGRGLHYCLHCDAHMFVGESVYVMGHGESAAHVAGIMLNFTDEVDLLLRGDEPSYSDETAEMLANHPIDVIDEDVTGVNNGENGWLESLEFEDGTVREYKGGFAMYGSEYNNGLARELGCEINEDGTIVVDDHGRTSVDGVYAVGDCTPGHNQLPVGMGQGAKAGIDLHFQLREFPRDSELLAEQGPVREDEVPGIPDALLEQAIDFHTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N0</accession>
    <name>R4W8N0_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445653.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04040"/>
    <dbReference type="EnsemblBacteria" id="AGN00759">
        <property type="protein sequence ID" value="AGN00759"/>
        <property type="gene ID" value="L593_04040"/>
    </dbReference>
    <dbReference type="GeneID" id="16182350"/>
    <dbReference type="KEGG" id="sali:L593_04040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.821"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_3_1_2"/>
    <dbReference type="OrthoDB" id="108454at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="15253" checksum="D475616CF93F7E34" modified="2013-07-24" version="1">MAAIPPEFQDLFEKQTLAHVATMLPNGLPHVTPVWIDYDPERDHLLFNTARGRRKERNVRANPAVGVSMCDPDDPYRYCSAWGEVVEVTEDGAVEHIDELARRYMDVDEYPNKGDEEGARVIVRIEADEVVTGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P7</accession>
    <name>R4W8P7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445703.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04290"/>
    <dbReference type="EnsemblBacteria" id="AGN00809">
        <property type="protein sequence ID" value="AGN00809"/>
        <property type="gene ID" value="L593_04290"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04290"/>
    <dbReference type="eggNOG" id="arCOG09018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217430_0_0_2"/>
    <dbReference type="OrthoDB" id="131338at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="41" mass="4681" checksum="9ADF111D595F58F9" modified="2013-07-24" version="1">MPKITVSDSLYSQLDQAADEDLEGALWEMVYLHRRGNDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S7</accession>
    <name>R4W8S7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 12">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8 12">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L593_10540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 12">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="8 12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10540"/>
    <dbReference type="EnsemblBacteria" id="AGN02053">
        <property type="protein sequence ID" value="AGN02053"/>
        <property type="gene ID" value="L593_10540"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2173"/>
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    <dbReference type="HOGENOM" id="CLU_015740_0_1_2"/>
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        <property type="reaction ID" value="UER00673"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:FMN binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017752">
        <property type="entry name" value="G3P_DH_GlpA_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03377">
        <property type="entry name" value="glycerol3P_GlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="14">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AGN02053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="599" mass="64962" checksum="D331A3ACDECD2A96" modified="2013-07-24" version="1">MIESTTGVLVIGGGSTGTGVARDLAMRGLDVTLVEKGNLTHGTTGRMHGLLHSGGRYAVSDQPSAVECIEENRVLRDIASHCVEETGGLFVKRPEDGEDYFQQKLEGCRECDIPAEVLSGEEAREVEPYLAKDIDKAIWVPDGAIDPFRLCVANAESATDHGARIQTHAEVTDVLIDEPEGTDERRVVGVEVRQTGGTGTRTHGVAEETERIYADHVVNATGAWAGQLGEMAGVEVAVQPSKGAMTVMNVRQVDTVVNHCRPKGDADIVVPHETTAILGTTDEAVDDPEHYPEEQWEVDLLIDNLAELVPILSEARTIRTFWGVRPLYEPPGTGTQDTTDITRDFFLLDHGERDDLPGMTSIVGGKFTTYRMMAEQISDHVCDLLGVSAECRTADVPLPGSEKPGRLDDAMEQYGLRSPIARRSAERLGSRTEAVLGTDAPNPVVCECEGVTRAELQHAIEGAGSDLNDVRIRTRASMGNCQGGICAHRMAAELHPRYEANAIRESHDELLQERWKGERHALWGDQLAQAALNYALHATTMNLDRDPARTGETPDFEAFDGGPTQTVAQPAADGGRRTGRGGDPPTDGDRDDRRRDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V7</accession>
    <name>R4W8V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10890"/>
    <dbReference type="EnsemblBacteria" id="AGN02123">
        <property type="protein sequence ID" value="AGN02123"/>
        <property type="gene ID" value="L593_10890"/>
    </dbReference>
    <dbReference type="GeneID" id="16181552"/>
    <dbReference type="KEGG" id="sali:L593_10890"/>
    <dbReference type="eggNOG" id="arCOG02861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112782_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="21969" checksum="4FBF4AE580B10C9C" modified="2013-07-24" version="1">MAAERSPAERTLDAELFGRDVTFDYSETWVAYSIVLLRVAMGWIFLQAGLEKYTSGGLDTVADDPLTGGWTASGYLEFALHPDNPLKDVFADMAGYGFIDPMVVWGQILIGLALLLGIVVRWSAFWGAVMMLFFWLSHLQGGLLAGLPLEHGWVVDETIVYAALLFGLGAIGAGRILGLDAWLEETEFAKNNSWVRYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W9</accession>
    <name>R4W8W9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447047.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11040"/>
    <dbReference type="EnsemblBacteria" id="AGN02153">
        <property type="protein sequence ID" value="AGN02153"/>
        <property type="gene ID" value="L593_11040"/>
    </dbReference>
    <dbReference type="GeneID" id="16182542"/>
    <dbReference type="KEGG" id="sali:L593_11040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2276"/>
    <dbReference type="eggNOG" id="arCOG07588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178209_0_0_2"/>
    <dbReference type="OrthoDB" id="119726at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10676" checksum="EA15471A09BC0442" modified="2013-07-24" version="1">MYLVEIKSSARRHNAAVGETINREGARHEFEDREAADEWARDLSADGEHTVWVQDAPPHADGLVDGYLMSRGSVRVAVAPFESQQRELSAIDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W986</accession>
    <name>R4W986_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ORF">L593_12670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447367.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12670"/>
    <dbReference type="EnsemblBacteria" id="AGN02473">
        <property type="protein sequence ID" value="AGN02473"/>
        <property type="gene ID" value="L593_12670"/>
    </dbReference>
    <dbReference type="GeneID" id="16182414"/>
    <dbReference type="KEGG" id="sali:L593_12670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2600"/>
    <dbReference type="eggNOG" id="arCOG00976">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_2"/>
    <dbReference type="OrthoDB" id="88476at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23746" checksum="AE4A994C1DD72068" modified="2013-07-24" version="1">MGLFSSDPGADDFESHRKAMVDRLVSHGRITDSAVADALRAVPRHEFVPEGRRKEAYADRPLPIGDGQTISAPHMVGIMAELIEVDPGDDVLEIGTGCGYHAAVTAELIGEDGTVYSVEYSDVLAERARATFDRLGYEVEVRIGDGRDGWPEHAPFDAAYFTCAAADLPDPVVEQTRVGGHVLAPIGTSQQTLYRHTKREDGTLDRESHGGVRFVQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W995</accession>
    <name>R4W995_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447387.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12770"/>
    <dbReference type="EnsemblBacteria" id="AGN02493">
        <property type="protein sequence ID" value="AGN02493"/>
        <property type="gene ID" value="L593_12770"/>
    </dbReference>
    <dbReference type="GeneID" id="16180162"/>
    <dbReference type="KEGG" id="sali:L593_12770"/>
    <dbReference type="eggNOG" id="arCOG04659">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104922_0_0_2"/>
    <dbReference type="OrthoDB" id="100417at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="22371" checksum="5927119403F1A8A9" modified="2013-07-24" version="1">MHRGWRTLTLAFVVASVSLAALLHSPDRLLGVAEGAAADPLLFAAVVLGLYLLRPLVLWPPTLVAVVVGYGYGVVVGLPVALAGAIVTSVGPFYLARWLGTDAPGADRVGSIAEEYLVTTGPVRGVTAARLAPIPADAVTVAASLAGVRFRDFAKGVLVGETPWSLAAVAVGASLATLSAEGATAGGFRLAALTTLAAIAVLAGPAYRRYGHRVSVPLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W996</accession>
    <name>R4W996_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446188.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06735"/>
    <dbReference type="EnsemblBacteria" id="AGN01294">
        <property type="protein sequence ID" value="AGN01294"/>
        <property type="gene ID" value="L593_06735"/>
    </dbReference>
    <dbReference type="GeneID" id="16181852"/>
    <dbReference type="KEGG" id="sali:L593_06735"/>
    <dbReference type="eggNOG" id="arCOG15127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199459_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="73" mass="7881" checksum="45C281FABE0F570D" modified="2013-07-24" version="1">MDEILDVAELVVDSGFEEAIAWLLRIVGILCILAGIGIWLFVDVTILVPIGLIVLGLLLVAIPQVLLLFLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W998</accession>
    <name>R4W998_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">L593_12795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447392.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12795"/>
    <dbReference type="EnsemblBacteria" id="AGN02498">
        <property type="protein sequence ID" value="AGN02498"/>
        <property type="gene ID" value="L593_12795"/>
    </dbReference>
    <dbReference type="GeneID" id="16182731"/>
    <dbReference type="KEGG" id="sali:L593_12795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2625"/>
    <dbReference type="eggNOG" id="arCOG00918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="OrthoDB" id="10264at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="425" mass="45711" checksum="EDECA49708FE06AA" modified="2013-07-24" version="1">MNHERSRELYDRALSVMPGGVNSTVRGATEPYPIFAESGDGGHVIDADGNRYVDWLMGLGPLLYGHDTPEPVSAAIQSHASNGPIYGVPTEIEVEHAEFVARHVPSVEMLRFVNSGTEATVSALRLARGHTGRDKVVVMQGGYHGAQESTLVEGEGDHVQPSSPGIPKSFAQHTIPVPFNDEAAIADVFEAHGDEIAAVLIEPILANYGIVEPVEGYHETVRDLTEDHGALLIWDEVITGFRVGGLQCAQGKYGIEPDLTTFGKLIGGGFPVGAIGGPAGIVEGFTPSGDVFQAGTFSGHPVTMAAGLESLRYAAEHDVHDHVSRLGQRLRDGLEEIVAERAPGYEVAGVDGIFKVHFTREGQGPVRNAADVKAGETDRWRRVFRPAMLEKGVLLSQNQYESQFVTYAHTEEDVEETLAAYEATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E7</accession>
    <name>R4W9E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447497.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13320"/>
    <dbReference type="EnsemblBacteria" id="AGN02603">
        <property type="protein sequence ID" value="AGN02603"/>
        <property type="gene ID" value="L593_13320"/>
    </dbReference>
    <dbReference type="GeneID" id="16180516"/>
    <dbReference type="KEGG" id="sali:L593_13320"/>
    <dbReference type="eggNOG" id="arCOG04662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070751_2_0_2"/>
    <dbReference type="OrthoDB" id="126170at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="230" mass="24069" checksum="4FD83177841A132E" modified="2013-07-24" version="1">MTQPLVATYAVLLVCLLATIAVAAGIGNVPALVNALVATGAAVLPTFGPVVGGAATVPVLDAAPLLSVWLATAGLVHTVGMFGPYDWVWWWDHVTHTLSATLLAALVYATFLAADRHVAGIGFDAPTLAAGTILVTLALGVVWEFLELWTRELGKARGVDPILEYYGLDDTVYDLAFDVLGAVIVVGLDVRIFLVVVEADPELAASVLGASIVVGFLAVVTIAAWLERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G4</accession>
    <name>R4W9G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ACT binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446383.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07720"/>
    <dbReference type="EnsemblBacteria" id="AGN01489">
        <property type="protein sequence ID" value="AGN01489"/>
        <property type="gene ID" value="L593_07720"/>
    </dbReference>
    <dbReference type="GeneID" id="16182201"/>
    <dbReference type="KEGG" id="sali:L593_07720"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1582"/>
    <dbReference type="eggNOG" id="arCOG04396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094842_0_0_2"/>
    <dbReference type="OrthoDB" id="104907at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20065" checksum="B364626F6E2A70A8" modified="2013-07-24" version="1">MTDEQIEPEATPDGGQTGAYTVRLELADEPGELLNALQPIADNGGNLLSIFHERGNITPRGQIPVEVDLECHPEQFERIVQALREAGMNVVQAGREEYGEELTLLLVGHVIDTDLSDTLDRIQTAAGASVTDLALSAPEGTDDVSSARLRIATSADRTEDVLETVRDVAAEKELHVIEPQLDSGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H6</accession>
    <name>R4W9H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative [LysW]-aminoadipate/[LysW]-glutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysZ</name>
        <name evidence="9" type="ORF">L593_07895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP</text>
            <dbReference type="Rhea" id="RHEA:41944"/>
            <dbReference type="Rhea" id="RHEA-COMP:9694"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78503"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP</text>
            <dbReference type="Rhea" id="RHEA:52632"/>
            <dbReference type="Rhea" id="RHEA-COMP:13311"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136714"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetylglutamate kinase family. LysZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.17" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446418.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07895"/>
    <dbReference type="EnsemblBacteria" id="AGN01524">
        <property type="protein sequence ID" value="AGN01524"/>
        <property type="gene ID" value="L593_07895"/>
    </dbReference>
    <dbReference type="GeneID" id="16182255"/>
    <dbReference type="KEGG" id="sali:L593_07895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1617"/>
    <dbReference type="eggNOG" id="arCOG00862">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_2_1_2"/>
    <dbReference type="OrthoDB" id="60029at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00036"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043744">
        <property type="term" value="F:N2-acetyl-L-aminoadipate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02082">
        <property type="entry name" value="LysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037529">
        <property type="entry name" value="LysZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="30503" checksum="91F9B9F44B373444" modified="2013-07-24" version="1">MTIVLKIGGARAVDPAGALADVAKLTAEGEDVVVVHGGSTAVDETLEQLGEEPTYVETPGGVVGRFTDERTMEVFEMVLPGKLNTDLVAGLQNEGVDAVGLSGVDGKLLAGPRKSAVRVQEDGKKKIKRGDHSGTIKQVNADLLETLLAGGYTPVATVPMAGKDGDDWLPVNADADRAAAAIAGALDATLVVLTDVPGVLADPDDESTLIETAETPAEFAQIEDAAEGFMTKKVMAATEAIEGGAERVVVADANVDEPVVTAVDGGGTHILASALDDGESDGESDAEADDESDEAAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P6</accession>
    <name>R4W9P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447752.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14610"/>
    <dbReference type="EnsemblBacteria" id="AGN02858">
        <property type="protein sequence ID" value="AGN02858"/>
        <property type="gene ID" value="L593_14610"/>
    </dbReference>
    <dbReference type="GeneID" id="16181350"/>
    <dbReference type="KEGG" id="sali:L593_14610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2983"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_15_0_2"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="123"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="39321" checksum="56A011191B189E4F" modified="2013-07-24" version="1">MAKTVTPEAATDDPIAHFLEEQRYHGKSQRTLDAYERVLRRFEAFLADPERVPTAPTTPAEATRRECMAWIHELRGEYARSTIASYAAYVHRFYGYMVRVEEFDSNPMALVREEMDERIEKNPTRRDLSVADMRAFVGSIEHPLHRALVVTLLKTGMRVGELCNLDLRDVAIHHELRAESATPTRAALDGRPNAIYVAAGTELDGDRSAANKRQRSTIVPVDDELQSTLVRWLAIRPDARSDPAPLFSPTDGDWGDRIEPHAVRRIVRQYAEQWGWYESGAGAGENVTPHYFRHFFTTHLRDRIGDRGVVKYLRGDVAEDIIDTYTHNWGGRVRGVYEANVYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T5</accession>
    <name>R4W9T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01764">
        <property type="protein sequence ID" value="AGN01764"/>
        <property type="gene ID" value="L593_09095"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1865"/>
    <dbReference type="eggNOG" id="arCOG06384">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139141_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043739">
        <property type="entry name" value="DUF5684"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18936">
        <property type="entry name" value="DUF5684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13882" checksum="F3D34B9302CF4712" modified="2013-07-24" version="1">MMLQALGTTILQEGAIGGFLVVYLAFIAIVIGGTWKTFTKAGEPGWAAIIPIYNVYVMLKIGGNEWWWLLVMLVPLVNIYAAYVMFKGVAEAFGNGLGFTLGLWFLGFIFWPLLGFGDYQYQGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U2</accession>
    <name>R4W9U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09270"/>
    <dbReference type="EnsemblBacteria" id="AGN01799">
        <property type="protein sequence ID" value="AGN01799"/>
        <property type="gene ID" value="L593_09270"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09270"/>
    <dbReference type="eggNOG" id="ENOG502N5HR">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2802138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="7481" checksum="D2A6E74259971AEC" modified="2013-07-24" version="1">MRTTDRMSLLYRFQALPAAQQLIVFSAVLDPLGLALGYLLGPSAGVDPIVGAAGGAIGSSMIVSLWFTVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA06</accession>
    <name>R4WA06_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447013.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10870"/>
    <dbReference type="EnsemblBacteria" id="AGN02119">
        <property type="protein sequence ID" value="AGN02119"/>
        <property type="gene ID" value="L593_10870"/>
    </dbReference>
    <dbReference type="GeneID" id="16182473"/>
    <dbReference type="KEGG" id="sali:L593_10870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2243"/>
    <dbReference type="eggNOG" id="arCOG00670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_2_2"/>
    <dbReference type="OrthoDB" id="115624at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="202" mass="21026" checksum="79B3F54982C2AAFC" modified="2013-07-24" version="1">MTLDRLRPLADKGLSPWVGLAARLGLTPNGVSLIAFAVAVAAGATFVVAGAEPLYYVVGGVLVGLSGWLDIVDGALARKLDVASAKGDLLDHVLDRYADIVLIAGLAAGIERYAIGFAAVTGVVMTSYMGTQIQAVGLGREYGGLIGRADRMVLIGVVATATTVYPDAVESLTLVGWLLVFFAIVGHFTAVQRFYGAWADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA26</accession>
    <name>R4WA26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02219">
        <property type="protein sequence ID" value="AGN02219"/>
        <property type="gene ID" value="L593_11370"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11370"/>
    <dbReference type="HOGENOM" id="CLU_2766272_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="69" mass="7926" checksum="A930C7A3394B1ED7" modified="2013-07-24" version="1">MRSNNLQMKFWVEKGCGGVASGYRSDERLDRSELQLIGHEWILLPVDNRYGIAVRPWPLAIAEITRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA96</accession>
    <name>R4WA96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13150"/>
    <dbReference type="EnsemblBacteria" id="AGN02569">
        <property type="protein sequence ID" value="AGN02569"/>
        <property type="gene ID" value="L593_13150"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13150"/>
    <dbReference type="HOGENOM" id="CLU_1623528_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="163" mass="18148" checksum="CA82AE1BC3C602DF" modified="2013-07-24" version="1">MYMGAIGLDAMAAENDDWNEGEQSSPPTDDGPPAETEQAEIQEVQVDDQEIAERMDEAEVFGTYTKRIGSYKLQIGPVFSNSGTYWVLSIYKEGVTGALYDSSEPLTDNDAGWLGIESNVQEAANDALEFANQNLIPSRKYRSQQRPSRSFSELEEMMEEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA98</accession>
    <name>R4WA98_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447473.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13200"/>
    <dbReference type="EnsemblBacteria" id="AGN02579">
        <property type="protein sequence ID" value="AGN02579"/>
        <property type="gene ID" value="L593_13200"/>
    </dbReference>
    <dbReference type="GeneID" id="16180230"/>
    <dbReference type="KEGG" id="sali:L593_13200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2701"/>
    <dbReference type="eggNOG" id="arCOG00721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109674_1_0_2"/>
    <dbReference type="OrthoDB" id="102178at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_6" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="17337" checksum="373F78D23E3C6F1A" modified="2013-07-24" version="1">MYVLDSSAFIREYHTEEQTATIPLVREELEDESAYRFDAMEGSGMHIHIPSQETVEKVERAARDLGDFEELSETDVRLVGATFELDGTLVTDDYAMQNVADRLGVAVEVIAHDGIEEQREWLFQCQGCGREFDDDKDRCPICGSGLSRKNPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA9</accession>
    <name>R4WAA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin--acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447528.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13475"/>
    <dbReference type="EnsemblBacteria" id="AGN02634">
        <property type="protein sequence ID" value="AGN02634"/>
        <property type="gene ID" value="L593_13475"/>
    </dbReference>
    <dbReference type="GeneID" id="16180644"/>
    <dbReference type="KEGG" id="sali:L593_13475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2756"/>
    <dbReference type="eggNOG" id="arCOG01940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_2"/>
    <dbReference type="OrthoDB" id="42041at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="36502" checksum="C16F285BBFD9E455" modified="2013-07-24" version="1">MTNTRRAILERLADGPRSGEALADDLDVSRAAIWKQVEALREQDFVIESDDEGYALVDVPEYGGDAIQFGLDAPFTIEFHEETGSTNDLARERAADGAEDLVIVAEEQTGGRGRLDREWASPSGGIWLSILVRPDRPPATIPLFTLAAAVAITTAVRESGVDAGIKWPNDVLVSERQRANDGSSGEQSESDGVPVSPDPDGEEAKLAGVLTEMEGEADRVEWLVVGMGINANLDADRLPDGSTSLRTELGEDVNRRLFVQRVLETFDDLRNDPDRILERWRADALTLGREVRVETASGDTVVGTAVDVEHPGTLLVETEDGVERIHAGDCEHLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC2</accession>
    <name>R4WAC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447593.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13800"/>
    <dbReference type="EnsemblBacteria" id="AGN02699">
        <property type="protein sequence ID" value="AGN02699"/>
        <property type="gene ID" value="L593_13800"/>
    </dbReference>
    <dbReference type="GeneID" id="16180846"/>
    <dbReference type="KEGG" id="sali:L593_13800"/>
    <dbReference type="eggNOG" id="arCOG09251">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080111_0_0_2"/>
    <dbReference type="OrthoDB" id="63117at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="28795" checksum="CE2DDB96F3EE25C5" modified="2013-07-24" version="1">MVPGPRLSQRRAALGFLVLGLLLCTAPVWIGFLHVDQPVSVYERAAVTTDDGRIEFVDRPLEAVQPVEISQDLGCTIANDDWPSRLCYHESAIASNDAEPIVGWTDDPDEDPWIRSQFSYVQVNGSVYDQMAFVGEARRRDADDAASRYPIVLGLERVDADAALRDLSIPSTDEAVPGVVRDAAATGTVRTQRSVDVPRHPIRTADGRYYRVYLRSTESPPLFDSVLYTVARFFAPVVGLLSLHSAWTRMEISYSSPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD1</accession>
    <name>R4WAD1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Valine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Valyl-tRNA synthetase</fullName>
            <shortName evidence="6">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">valS</name>
        <name evidence="11" type="ORF">L593_14025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447638.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14025"/>
    <dbReference type="EnsemblBacteria" id="AGN02744">
        <property type="protein sequence ID" value="AGN02744"/>
        <property type="gene ID" value="L593_14025"/>
    </dbReference>
    <dbReference type="GeneID" id="16181020"/>
    <dbReference type="KEGG" id="sali:L593_14025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2870"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="48"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="709"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="6">
        <location>
            <begin position="609"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="975" mass="108918" checksum="76A41FD8E3B1EA38" modified="2013-07-24" version="1">MPDATQSDPDDADANAASTPDQHDSSSTDAPAASLEGEYDPREAESRWQDYWLEAGVYSYDDDIEDPDTAYSIDTPPPTVSGSLHMGHLYGSTLQDFAARFHRMDRQDTFFPFGYDDNGIASERLTERELDIRHQDFSRREFQAKCREVCQDYEEEFTEKMQSLGMSIDWNRTYKTIEPRVQRISQLSFIDLYEQGREYRQKAPAIWCPDCETAISQVEMEDAERDSAFNDIPFELVEAGDEPDADAVAEAAEERPYAPPTEPGDDLVISTTRPELLPACVAMFVHPDDEANAHLVGGTAKVPLFGHEVPIYEDDRVDLETGTGLVMCCTFGDQTDIEWYQAHDLDLRVAIDASGTMTDIAAEYEGKSTEEAREAIIEDLDDAGLLYDHDPITHDVQVHERCEVPVEYRVSKQWYVELLDRREEYLEAGREMEWYPEKMFTRYKHWIEGLEWDWLISRQRDSGIPFPVWYCEECDEPILANREDLPVEPIEDEPPIDACPACGHDAFEPEEDVFDTWATSSLTPLINAGWDWDPEADPADGIGHASDAVDGAFTLDNPELYPFDLRPQGHDIISFWLFHTVVKCYEHTGEVPFEGVMINGHVLDEHREKMSKSKGNVVTPEEVLDAFPVDAARFWAAGTAVGDDFPFKEGDLEAGERLLRKLWNASKLVHQLAPVDVEPPGAASGDDTGDAVLDPDDIAPDDLDLEPIDEWLLARQDAVLESITEKYREHEYAKARTELRTFFWETFCDDFLEIAKQRLDDADRAALADGTADAESRSAAYALRTAHEQFCSLFAPILPHVTEEIWQAAYADGSEAASIHATDWPDATGQTADLDAGETALAVISALRGYKTDNGLPLNADLSAVTVYGDVAGFEGAVADVMHVEEVTAIEGDAPTTTRIVDVDLDYATLGPQFGEQIGEFDAAIEAGEYEETDEGLVIAGETLDPDHYELVREQTYDGEGELLAIDSATVIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF8</accession>
    <name>R4WAF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_14725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447773.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02879">
        <property type="protein sequence ID" value="AGN02879"/>
        <property type="gene ID" value="L593_14725"/>
    </dbReference>
    <dbReference type="GeneID" id="16181429"/>
    <dbReference type="KEGG" id="sali:L593_14725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3006"/>
    <dbReference type="eggNOG" id="arCOG00626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_2"/>
    <dbReference type="OrthoDB" id="35850at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="443" mass="47947" checksum="11F1F3F7CBB280EF" modified="2013-07-24" version="1">MVNLALSLAQVVVALVLVVLNGFFVAAEFAFVRIRGTSVEQLAEEGRTGAGTFQEVMENLDDYLATTQLGITIASLGLGWVGEPAVAALIEPVLESVLPASLIHLVAFAIGFSIITFLHVVFGELAPKTLAIAQTERLSLFLAPPMKIFYFLLYPGIVVFNGAANAFTRSLGVPPASETDETLGERELLRVLTRSGEGGDIDVAEVTMIERVFDLDDIVVREVMVPRPDVVSVPADSSLSDLHSIVLEEGHTRYPVLQADDGDQVVGFVDVKDVLRAEVGGENAEVVGDIAREIIIAPETMALSDLLRQFREDQQQMAAVIDEWGALEGIATVEDVVEALVGDLRDEFDVDEREPSIRQRDDDGYDVDGGVPLSTINDVIEGDLTSEEVETIGGLVLEQLDRAPERGDRVEIDRHVLEVTGVEGTRISTIRVHDRAVDDPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAH4</accession>
    <name>R4WAH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_15125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447853.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15125"/>
    <dbReference type="EnsemblBacteria" id="AGN02959">
        <property type="protein sequence ID" value="AGN02959"/>
        <property type="gene ID" value="L593_15125"/>
    </dbReference>
    <dbReference type="GeneID" id="16181758"/>
    <dbReference type="KEGG" id="sali:L593_15125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3089"/>
    <dbReference type="eggNOG" id="arCOG04602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327184_0_0_2"/>
    <dbReference type="OrthoDB" id="120474at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="91" mass="9880" checksum="97E9241A8EC458B1" modified="2013-07-24" version="1">MTEASVTEGSITATYRETPAERLLEFERDGRTAAIAQNVEGYAMLKVRPSADGDELERYYGFDMALDHAAELLGVAPAELPVPEQAADMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VRZ8</accession>
    <name>R4VRZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_00125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00125"/>
    <dbReference type="EnsemblBacteria" id="AGM99979">
        <property type="protein sequence ID" value="AGM99979"/>
        <property type="gene ID" value="L593_00125"/>
    </dbReference>
    <dbReference type="GeneID" id="16180994"/>
    <dbReference type="KEGG" id="sali:L593_00125"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.25"/>
    <dbReference type="eggNOG" id="arCOG01301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068376_1_1_2"/>
    <dbReference type="OrthoDB" id="75596at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGM99979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="26578" checksum="72A0585A95A71FD0" modified="2013-07-24" version="1">MSDAARIETDVCVIGAGPAGLTCALYTARAGLDTVVVDGGPSILARNAHLENVPGFPGGVDAREFLAATRTQVEDTGGRFVDGFVDGVTRAEGDDRLVATTADRTVIADSLVAASWKDCSYLEGFPVETTERGTKTFLEVDDSGRTGVDGIYATGRIGGKAHQTVVVAGHGAEVGIAVIHDADVPFYHDWVTPAGYFSDRDRDVPPGCEEIDEAERRERLAASREHRRQLLDGQPESPATHPSLRNDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSC2</accession>
    <name>R4VSC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_00800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00800"/>
    <dbReference type="EnsemblBacteria" id="AGN00115">
        <property type="protein sequence ID" value="AGN00115"/>
        <property type="gene ID" value="L593_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.164"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="70"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="261"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="452"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="66704" checksum="39B5C890ABA8C206" modified="2013-07-24" version="1">MTDDESDTEPSDASTDAVPDGGKATAGPTGTTAPGSAAERGAGTEGTDPDVGDDDQSTADADAGQRQVTSGAQSVVRALENSGIEYLFGVQGGAIMPVYDALYDSEALTHVTMAHEQGASHAADAYGIVSGEPGVCLATSGPGATNLVTGIADADMDSDPMIALTGQVPTDFVGNDAFQETDTTGVTDPITKHNIFATDADTVGDDVGTALELSRTGRPGPTLVDLPKDVTNAETDREPGAPQTPETYTVQETAERANVVDAARAIEDAERPAILAGGGIVKGDASDELYEFATEYEIPVVTTMPGLGAFPEDHELSMEMAGMHGTGFANMAITHTDLLIGIGTRFDDRLTGGIETFAPDAEVVHVDIDPAEISKNIHADYPLIGDAATVIEQLHDEVEAAPEADEWREQCRTWKKEYPMDYPIPEDRPLQPEFVVEALDEATGDDAIVTTGVGQHQMWACQYWEFTEPRTWVSSHGLGTMGYGMPAAIGARLAADDDQDVVCFEGDGSFLMTMQELSVAVREDLDVTVAVLNNEYVGMVRQWQDAFFEGRHAASEYGWCPEFDKLAEAFGARGWAVDDYDEVADAVEAAVDYDGPSVIDFRIDPQANVYPMVPSGGDNGKFALSEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VST0</accession>
    <name>R4VST0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="7" type="ORF">L593_01410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445129.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01410"/>
    <dbReference type="EnsemblBacteria" id="AGN00235">
        <property type="protein sequence ID" value="AGN00235"/>
        <property type="gene ID" value="L593_01410"/>
    </dbReference>
    <dbReference type="GeneID" id="16182493"/>
    <dbReference type="KEGG" id="sali:L593_01410"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.287"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OrthoDB" id="107212at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="96" mass="10428" checksum="0B07344E7BA92267" modified="2013-07-24" version="1">MPDSHGPRRGTREKLSNDPRDRGTSPPQRAIAEFEEGQSVHLRLDPSVSDGRFHPRFNGHTGVVVGEQGSAYKVRIDDGGKAKTIIATAAHLTAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSY3</accession>
    <name>R4VSY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445194.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01735"/>
    <dbReference type="EnsemblBacteria" id="AGN00300">
        <property type="protein sequence ID" value="AGN00300"/>
        <property type="gene ID" value="L593_01735"/>
    </dbReference>
    <dbReference type="GeneID" id="16179922"/>
    <dbReference type="KEGG" id="sali:L593_01735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.352"/>
    <dbReference type="eggNOG" id="arCOG02257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080075_1_0_2"/>
    <dbReference type="OrthoDB" id="81123at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="21851" checksum="B3EEA603CF8DCDEB" modified="2013-07-24" version="1">MSSAPTREVARRVFAREFNDASYTFKESDDERAPNYALLPTGERANRVFFVGTLTEKEDVGDDSEYWRGRIVDPSGTFFVYAGQYQPEAASMLRELEAPEYVAVAGKPRTYETEEGQVNVSVRPESITVVDEGTRDRWVVEAAERTIERIEAFDDETSEYATMAREEYGDDTSDYLEAAIEALETIEGEPAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTA6</accession>
    <name>R4VTA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02470"/>
    <dbReference type="EnsemblBacteria" id="AGN00445">
        <property type="protein sequence ID" value="AGN00445"/>
        <property type="gene ID" value="L593_02470"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02470"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120387_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="159" mass="16757" checksum="50AC663250D9B431" modified="2013-07-24" version="1">MTAVDVRLEPATDDEALAYVEGLLAENDLPTSDVQEKQDCFSVAYADGDRVGIGGVERYGPNGLLRSVVVAATARGRGVGTALCDELEAQAREAGVERLYLLTTTAAEFFAARGYETIERSDARAAIRDSAEFAELCPDAATCMETVLGSGTAVDDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTI1</accession>
    <name>R4VTI1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ORF">L593_02920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445429.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02920"/>
    <dbReference type="EnsemblBacteria" id="AGN00535">
        <property type="protein sequence ID" value="AGN00535"/>
        <property type="gene ID" value="L593_02920"/>
    </dbReference>
    <dbReference type="GeneID" id="16180377"/>
    <dbReference type="KEGG" id="sali:L593_02920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.591"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131909_0_1_2"/>
    <dbReference type="OrthoDB" id="116327at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="14503" checksum="4C8F0F7A8F83BB9F" modified="2013-07-24" version="1">MQGSLPPEAQEKVEELQDLQETAQEVAVQKNEAETELTESQSALEELEDVDEDTVMYREVGELLLETDYETAKDDLEENVESLEIRVETLQKQEDRVQEQFEELQQELQEMLQGGGGPMGGMGGGPGAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU56</accession>
    <name>R4VU56_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">L593_03870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445619.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03870"/>
    <dbReference type="EnsemblBacteria" id="AGN00725">
        <property type="protein sequence ID" value="AGN00725"/>
        <property type="gene ID" value="L593_03870"/>
    </dbReference>
    <dbReference type="GeneID" id="16180698"/>
    <dbReference type="KEGG" id="sali:L593_03870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.786"/>
    <dbReference type="eggNOG" id="arCOG01597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_2"/>
    <dbReference type="OrthoDB" id="57699at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="114"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="405" mass="43311" checksum="5D733ECB6295762E" modified="2013-07-24" version="1">MTTSLTPPGRTLGIVGGGQLGRMLAEAASPLGVEVIVLDPTPDCPASSVARDQLVADFDDADAIAELAERSDALTFEIELTDPEGLERAAEEAGVPVHPKPDTLRTIEDKLVQKRSLRDAGIPVPEFREVDDADDLRAAIDDLGASLMLKARTGGYDGRGNFPVESAADAERAMEEIGGPAMAERFVDFERELSVIGVAGAEATDAFPAGENVHREEILRETVAPARADDAVLEEAQSVAADVLELLEGRGVYGIELFEHSEPREDGARITVNEIAPRPHNSGHWTIEGAITSQFENHVRAVLGLPLGNTDVRSPTVMANLLGDSDRARPIAQESVGDTPDAVPVRGVDDLLATGGAHLHWYGKREVRPLRKLGHVTLTGDGTGIEDRGELLDLVRDLRDDVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU77</accession>
    <name>R4VU77_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0212 protein L593_03995</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0212 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445644.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03995"/>
    <dbReference type="EnsemblBacteria" id="AGN00750">
        <property type="protein sequence ID" value="AGN00750"/>
        <property type="gene ID" value="L593_03995"/>
    </dbReference>
    <dbReference type="GeneID" id="16180098"/>
    <dbReference type="KEGG" id="sali:L593_03995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.812"/>
    <dbReference type="eggNOG" id="arCOG02119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138334_0_0_2"/>
    <dbReference type="OrthoDB" id="101789at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01223">
        <property type="entry name" value="UPF0212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007564">
        <property type="entry name" value="UPF0212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42199">
        <property type="entry name" value="PTHR42199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04475">
        <property type="entry name" value="DUF555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016934">
        <property type="entry name" value="UCP016934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13264" checksum="B4445E1809A0A975" modified="2013-07-24" version="1">MSNYLVVMEAAWLVRDVESIDDAIGVAVSEAGKRLNDKDMDYVEVDVGATGCPACGEPFDSAFIAAETALVGLVLEMEIFNADSEEHAQRIAKSEVGGALRDVPLDVVETIEREGDADDEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU96</accession>
    <name>R4VU96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445664.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00770">
        <property type="protein sequence ID" value="AGN00770"/>
        <property type="gene ID" value="L593_04095"/>
    </dbReference>
    <dbReference type="GeneID" id="16180819"/>
    <dbReference type="KEGG" id="sali:L593_04095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.832"/>
    <dbReference type="eggNOG" id="arCOG11916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320305_0_0_2"/>
    <dbReference type="OrthoDB" id="82894at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="21819" checksum="553B55380A1F14AE" modified="2013-07-24" version="1">MSLLQVLPLAIVMVAGPQFLSAIFLATTDRWRANSLAFVAGAALSISAVVTAAYLLGGGVRDQTGSSGVLDAVILGLLLLAMVRVYLNREESEPPEWMGKLTTASPRFSFRLGVLLLGFFPTDVITSVSVGSFLAAQEAPLTDALGFLAVTLTLLALPSLTVLAFSERAEAFLPRVREWMNDNAWIVNEVVLLFFVAIVGSNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUJ3</accession>
    <name>R4VUJ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate mutase sigma subunit</fullName>
            <ecNumber evidence="3">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamate mutase S chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glutamate mutase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glmS</name>
        <name evidence="5" type="ORF">L593_04680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylamine corrinoid protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylaspartate mutase GlmS subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445779.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04680"/>
    <dbReference type="EnsemblBacteria" id="AGN00885">
        <property type="protein sequence ID" value="AGN00885"/>
        <property type="gene ID" value="L593_04680"/>
    </dbReference>
    <dbReference type="GeneID" id="16181012"/>
    <dbReference type="KEGG" id="sali:L593_04680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.956"/>
    <dbReference type="eggNOG" id="arCOG01710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136705_0_0_2"/>
    <dbReference type="OrthoDB" id="90624at2157"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00526">
        <property type="entry name" value="Me_Asp_mutase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006394">
        <property type="entry name" value="GlmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01501">
        <property type="entry name" value="MthylAspMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2 3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="15532" checksum="C3F0B14E494783EA" modified="2013-07-24" version="1">MTTTVILGVIGSDAHAVGITILEQALDAAGFDVRNLGVQTGQDEFVEAAATSDAEAVLVSSLYGHAERDCDGLHEALAERGIDPATYVGGNLAVGQADHESIRERFERMGFDRVFDAETDPEDAIVALRRDLGLAETDAERSRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUK5</accession>
    <name>R4VUK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carotenoid biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445794.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04755"/>
    <dbReference type="EnsemblBacteria" id="AGN00900">
        <property type="protein sequence ID" value="AGN00900"/>
        <property type="gene ID" value="L593_04755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181139"/>
    <dbReference type="KEGG" id="sali:L593_04755"/>
    <dbReference type="eggNOG" id="arCOG02835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070738_0_0_2"/>
    <dbReference type="OrthoDB" id="77334at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017823">
        <property type="entry name" value="CruF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03460">
        <property type="entry name" value="crt_membr_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="284" mass="30504" checksum="C88085D9F4233551" modified="2013-07-24" version="1">MDRLGGETGRERVESRLDSIVHDNRVTIAVTFPLVGVVLLLAGEAGYVPDALAFNPYLMVAAVTIMALPLASGIAPIVDRRAAVGLLALAAFTWAIELVGVQTGLPYGEFTYERELGPMVFGDVPLALPIFFVPILLNSYLLGILVLGDRADRLAIRFPTVVALVVVLDLVLDPGAVALDFWGWTDPGVYYGVPVINFLGWILAATVAVGILTVAFDHDAIVSRLETCPYLLDDLINFGIFWGLVNVAAFNLVPALVATGILLVLVRAPWFDFAGLPFGSRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM8</accession>
    <name>R4VUM8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">FMN adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Flavin adenine dinucleotide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ribL</name>
        <name evidence="5" type="ORF">L593_00055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal FAD synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444860.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00055"/>
    <dbReference type="EnsemblBacteria" id="AGM99965">
        <property type="protein sequence ID" value="AGM99965"/>
        <property type="gene ID" value="L593_00055"/>
    </dbReference>
    <dbReference type="GeneID" id="16182389"/>
    <dbReference type="KEGG" id="sali:L593_00055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.11"/>
    <dbReference type="eggNOG" id="arCOG01222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_1_2"/>
    <dbReference type="OrthoDB" id="79845at2157"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046444">
        <property type="term" value="P:FMN metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02115">
        <property type="entry name" value="FAD_synth_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024902">
        <property type="entry name" value="FAD_synth_RibL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGM99965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="17062" checksum="89636BB015B52A78" modified="2013-07-24" version="1">MSEDGSSTAADAAGDRRVVAQGTFDILHPGHVHYLEEAASFGDELYVIVARDANVSHKPTPIIPETQRRDLIDALAVVDHAILGDPDDIFVPIERIDPAVIVLGHDQHHDESSLEAALEERGLDCSIERASPRPQSDSDELLSTGRIIEKILRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUR0</accession>
    <name>R4VUR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445859.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05080"/>
    <dbReference type="EnsemblBacteria" id="AGN00965">
        <property type="protein sequence ID" value="AGN00965"/>
        <property type="gene ID" value="L593_05080"/>
    </dbReference>
    <dbReference type="GeneID" id="16181144"/>
    <dbReference type="KEGG" id="sali:L593_05080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1037"/>
    <dbReference type="eggNOG" id="arCOG00121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448081_0_0_2"/>
    <dbReference type="OrthoDB" id="7254at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="658" mass="70094" checksum="6258FA4B76789B47" modified="2013-07-24" version="1">MPGLSVACGDAVGGSDDSSGDEHAFEDALDATAVLDHYATTIDLEGDGVAVGSTEYDGYPIRRAETEHGTAFLEGELYDVEDPDAHLERVAAMIADDDLEGLRAWVGARDGDYLLAVADGDAVAMLNDPFGRLPAYTATIGGATVCSRELGFVRALASGRDDPLELDRLALAQLLSFGYPLGNRTPFAEVRTVPPGSLVRFGDATDSACESTADAGPRIESLYEHDFDDCTNDDRDVETNADELADRIATACQRRASPDRPTVVSLSGGLDSRIAAAAYDASDLPATATTFQRGGGSDAEVGAAGAVAKRLGLDWRVYDVESSPERRRTLLETKQGTNYLGMAFILDFFEQLRNRHGTATYVTGDGGDKVLVDLEPATTPGSESELVDHAIAANSRLSLETAADVANVDADAIRASVAQRIGSYPESDLARRYVHFLVRERGVNFLVQGEDRNRYYAWSVSPFYALPVFEYAMNCPDDQKAYRGLVAAILERFDPGLVDLPYPNYGAPISTRRYRAKQFVYDALERYPAIRGRVVDLVTGDGATPGLATEAIRGDLPWLDRAGLSAAATAGVLESPEAHSRIQFQYLSTVTALARAVVTDAESESPPEAAATPATSVQGAGAEGAGGHSTTSDGDRMPDADPADEQPTPGPRSARAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUS7</accession>
    <name>R4VUS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445879.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05180"/>
    <dbReference type="EnsemblBacteria" id="AGN00985">
        <property type="protein sequence ID" value="AGN00985"/>
        <property type="gene ID" value="L593_05180"/>
    </dbReference>
    <dbReference type="GeneID" id="16181251"/>
    <dbReference type="KEGG" id="sali:L593_05180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1057"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="203"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="266"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="673" mass="71906" checksum="492D3BEAC4C3644F" modified="2013-07-24" version="1">MSSPLHSPSRGLVVTTDEALADALEAALLGGRLDQIDVASDAAAALQSIDAEAAQPVGCVLVTDAIAAESPPDVVAELRGSNGRLPILVVGDDARDAWRATAAGADGFVPREPPEALRETVDERIEAYERRRWEAADSAALEALLATVQGSVYVKDAEARHLRKSREQGDIPPEEAIGKTDAEIYDEATYQEDLDVLRTGEGFDAKSESFETTDGTHWLETSKHVWRDDDGEIAGLVGYTEDVTDSVERQERIADQQRRLEAVAESYTHDLRTPLSLATGYLEQARMTGEEEFLDEVEDALERIDEMLDDLKAVATSEDEDVAETREAEDPLPSTSLASVARDVWRLTGTDAATLDLDFPESTVVQVAPGTLRTVLENLFKNAVQHAGDDVTVQVTCLDEDGGFAVEDDGPGIPAADRDAVLERGFSTSDTGTGVGLGLVSEIADRLEWDVRVTESESGGARIELANCPTVQDPPSTAGEWTQRNLDSTATIGYDDEQSEASTTGTAGQWTVTGAGRSIIEDVNEFQFAYGTVEPPVRIEARIADLEAVSEWSFGGVMVRSAVDPDAAYAGIGPSVGRGTTLLWRPAPDELGVGQAVADAADTHDWARLEVADGTVTASVSRDGTDWTPVDQRRVALEGPIHAGIAVCSTIPGEHCTATFESVSLCVRSSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV57</accession>
    <name>R4VV57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05855"/>
    <dbReference type="EnsemblBacteria" id="AGN01120">
        <property type="protein sequence ID" value="AGN01120"/>
        <property type="gene ID" value="L593_05855"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05855"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447339_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="117"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="610" mass="67165" checksum="38C3EE718E966CA1" modified="2013-07-24" version="1">MVSRRKFVSLAGTTGAAAVAGCIGGDGDGDDSDSDSGSSDGGDSGSDTGGDDTGGDDSDGSSSGPTYPDTNRWFVTFSGSFTPDQFQYNPLVGWFIPHDQFGLFAPWVKYLNGLDEWVPHLVTDWEHDGNEFVLTVSDQFTWGTSGETVTAEDLKLQLEIQKNANDAAWDFIVDGGVNAASDTELRIEYAEGTRPSFVTYSVLPKVAAYAPSIWSGEEDNESPAEVEVNTPDPSGPIALTEATSNYNRTRPRDGLDDYEDHFLADHYNWNGYKMEYRSSNNAAHQSMIANEVDGIHSMFVKPGTLENFPDTWSQFQIPGNFGMAIWPWHGDGPFSERNVRQAFYYSLDRGSIIQNVGETTKVSHHPAPTGLTWASVDSYLGDKEPEGFNVYDLDLDQAESLLSEAGYSFGDIDATIAFPSGWSDWAVAAQSAIDQLNNAGWNASSDARSGGPGGYINQLGEEFPLGVDQHTPGGQPRQNLPYFGFRYILRNVLRDPEGHFAGYTKDEVELPEVGTVNIDDTLDALSTATDEAEQEELIRQLALVVNKDVPVFYMMEKYEQSFINTRKFSIPESSKHFNAFWPLWWLPKLDEKLEDATEEDTPGLLKAKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVP0</accession>
    <name>R4VVP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445215.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01850"/>
    <dbReference type="EnsemblBacteria" id="AGN00321">
        <property type="protein sequence ID" value="AGN00321"/>
        <property type="gene ID" value="L593_01850"/>
    </dbReference>
    <dbReference type="GeneID" id="16179969"/>
    <dbReference type="KEGG" id="sali:L593_01850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.374"/>
    <dbReference type="eggNOG" id="arCOG00446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_1_2"/>
    <dbReference type="OrthoDB" id="75691at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="267" mass="28327" checksum="D930D12E00A2FCC9" modified="2013-07-24" version="1">MQILVTVKEVGQLGDEVVIDDGDVAESALEYDLNEWDEYALESAVQLSETLDDVEVVTATIGPERSEETIRMALAKGADRAVRIWDDAIANDDGDGLLDTRTRVELLSAVVEREEPDLVLTGVQSADATFGSTGVALAEAIDTAWAAVVNDLEIDADAGTASVHRELEGGIEELTDVELPAVLTIQTGINEPRYASLRGIRQAQSKPLDVLDLAELGVPADAIAGSLVTTAMYEPESSSDAELWEGDAEATAGQLADFLRDSGVIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVQ4</accession>
    <name>R4VVQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445230.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01925"/>
    <dbReference type="EnsemblBacteria" id="AGN00336">
        <property type="protein sequence ID" value="AGN00336"/>
        <property type="gene ID" value="L593_01925"/>
    </dbReference>
    <dbReference type="GeneID" id="16179987"/>
    <dbReference type="KEGG" id="sali:L593_01925"/>
    <dbReference type="eggNOG" id="arCOG03006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144575_0_0_2"/>
    <dbReference type="OrthoDB" id="105752at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14250" checksum="F9554152077D923F" modified="2013-07-24" version="1">MGYSKVSLDEVEAHRLEEPERTILPIGVELRPAKMRPSVWEYEAGETSNRHRQREQEELYVPLAGRFEVAIAGNEGGEDGTGDEELLELETGDYLVVDPETTRQLTAVTDGRILVVGAPNVTDDGVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVQ9</accession>
    <name>R4VVQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase of beta-lactamase fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445235.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01950"/>
    <dbReference type="EnsemblBacteria" id="AGN00341">
        <property type="protein sequence ID" value="AGN00341"/>
        <property type="gene ID" value="L593_01950"/>
    </dbReference>
    <dbReference type="GeneID" id="16182305"/>
    <dbReference type="KEGG" id="sali:L593_01950"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.396"/>
    <dbReference type="eggNOG" id="arCOG00515">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_3_0_2"/>
    <dbReference type="OrthoDB" id="49013at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="30628" checksum="C8D1FEB1D0416267" modified="2013-07-24" version="1">MPTSDWDDWLVRDIEVADPDGLAAWYLGCNGFVVKAGDGTTIWIDPYVGLGDPPRTVRMIPVPFDPADVEAADAVLATHEHTDHVHGPSQAPILESTGAPFYAPDDSLAVARDEEDWQADHDIADDQFVAVAEGDTFEVGEVTVHVEFAHDPDATHPVSYVIEYGDATLFHGGDTKPHDDFEELGEAYDVDLGILAFGTIGTIDDKETGEPVRTKWYNTENQIVEAASDLQFDRLLPSHWDMWKGLTADPKVLHHHARSFAYPERLEIVEIGDRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW76</accession>
    <name>R4VW76_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc-containing ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_07650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7 8">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 8">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446369.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07650"/>
    <dbReference type="EnsemblBacteria" id="AGN01475">
        <property type="protein sequence ID" value="AGN01475"/>
        <property type="gene ID" value="L593_07650"/>
    </dbReference>
    <dbReference type="GeneID" id="16182179"/>
    <dbReference type="KEGG" id="sali:L593_07650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1568"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178207_0_0_2"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009157">
        <property type="entry name" value="Fd_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000068">
        <property type="entry name" value="Zn_Fdx_Sulfol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000068-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="12026" checksum="5CAC07F7AAFC87D7" modified="2013-07-24" version="1">MAIDPNFEENREVVDEHEGHDVWGPVDEPEELGIHGTHVAVDFDICIADGACLEDCPVDVFEWVDSPDHPESEIKADPTHEEQCIDCMLCVDVCPVDAIDVDAGRAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW98</accession>
    <name>R4VW98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445440.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02975"/>
    <dbReference type="EnsemblBacteria" id="AGN00546">
        <property type="protein sequence ID" value="AGN00546"/>
        <property type="gene ID" value="L593_02975"/>
    </dbReference>
    <dbReference type="GeneID" id="16180398"/>
    <dbReference type="KEGG" id="sali:L593_02975"/>
    <dbReference type="eggNOG" id="arCOG02868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_2"/>
    <dbReference type="OrthoDB" id="105143at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="245" mass="26605" checksum="8C68D2167FF28855" modified="2013-07-24" version="1">MDDEDTITRRRALLAGGATIGFGAGVAYLATRSASTDSAYEPATIHEGSGTSGLGIELSGRPVVGDAAAPVDLYYWTDYLCPFCARFEANTLAKIGRNYVDAGQVRIPFLLFPNIGEYSMPAAIWDRCVWEQVGADDPMAYWNWHGEVFDVQRSSGEDWADDATFAEVTERVEGVSRSAVESCRETRSDAIRDRLDADVSAAQSAGIRGTPAFVVYNRENDRAGRLVGAHPYENFASAIDQVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWJ5</accession>
    <name>R4VWJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446509.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08350"/>
    <dbReference type="EnsemblBacteria" id="AGN01615">
        <property type="protein sequence ID" value="AGN01615"/>
        <property type="gene ID" value="L593_08350"/>
    </dbReference>
    <dbReference type="GeneID" id="16182022"/>
    <dbReference type="KEGG" id="sali:L593_08350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1711"/>
    <dbReference type="eggNOG" id="arCOG04896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062679_0_0_2"/>
    <dbReference type="OrthoDB" id="37705at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="31121" checksum="2073898FB1CD1BBC" modified="2013-07-24" version="1">MADPDRPFDFLHANERPEKPRETGITEIRGPYYDPMGPRELRDILETMGHYVDIYKFSGGSFALMPEEVVTEMIDCCHEFDVRVNTGGYVENVLLRNNDAVGQYVEECDRLGFDIVEISSGFLAIDTDDMVAMTELVAEHGLEPKPEINVQFGAGGASDPEELEREGQQDPQQAIEEGRRHLDAGADHLMVEAEGITEEVREWRTDVVYEIENALGMENLVFEAPGPEMFEWYVKNFGPNVNLFVDNSQIVELECMRSGLWGKATSWGRVVTYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWK3</accession>
    <name>R4VWK3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="5">HMG-CoA reductase</shortName>
            <ecNumber evidence="5">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445555.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03550"/>
    <dbReference type="EnsemblBacteria" id="AGN00661">
        <property type="protein sequence ID" value="AGN00661"/>
        <property type="gene ID" value="L593_03550"/>
    </dbReference>
    <dbReference type="GeneID" id="16180715"/>
    <dbReference type="KEGG" id="sali:L593_03550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.721"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_2_2_2"/>
    <dbReference type="OrthoDB" id="26445at2157"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="416" mass="42266" checksum="CCA44D0CD2E7B1F2" modified="2013-07-24" version="1">MTDPQDLADRVLDGELRLYELDDQADADAAATARRLVIEAETGADLEAVGEYAFPAGQAEPNIENMLGAAQVPMGVVGPLAVDGGAASAAATDAVDDPNGPPEHYLPLATTEGALVASVNRGASVITESGGADARVVENGMTRAPVFRVAGIAEAEQVVEWVDEHEADLREAAESTTSHGELTAVDPYVVGDSVFLRFVYDTKDAMGMNMATIATREAAGLVEDETPADLVALSGNLCSDKKPAAINAVEGRGRTVVADVTIPTELVEERLGTTPAAIEEANTRKNLIGSAKAGALGFNAHAANVVAAAYLATGQDAAQVVEGSNAITTIEDRGDELYASVSLASLEVGTVGGGTNLATQSEALEVLGFGGGGDPPGSNGDALAEVIAAGALAGELSLLAALASRHLSSAHEELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWN3</accession>
    <name>R4VWN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446544.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01650">
        <property type="protein sequence ID" value="AGN01650"/>
        <property type="gene ID" value="L593_08525"/>
    </dbReference>
    <dbReference type="GeneID" id="16180830"/>
    <dbReference type="KEGG" id="sali:L593_08525"/>
    <dbReference type="eggNOG" id="arCOG09397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175271_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11284" checksum="24FBA901E0301A22" modified="2013-07-24" version="1">MVNVSTIDGIEYGFRIMIYAVLVVLIAIVFGAISWILIDAGGDLLTAIGGIIGLVGGLIVYAGALGVLYKVIADGVERGVQAANVTLPRRRAEPVEEEDEVEAVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWP6</accession>
    <name>R4VWP6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheS</name>
        <name evidence="10" type="ORF">L593_08600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446559.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08600"/>
    <dbReference type="EnsemblBacteria" id="AGN01665">
        <property type="protein sequence ID" value="AGN01665"/>
        <property type="gene ID" value="L593_08600"/>
    </dbReference>
    <dbReference type="GeneID" id="16182391"/>
    <dbReference type="KEGG" id="sali:L593_08600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1761"/>
    <dbReference type="eggNOG" id="arCOG00410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OrthoDB" id="22747at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="302"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="560" mass="60940" checksum="4A2A93957593FD62" modified="2013-07-24" version="1">MELPAAQVAVLNAASANDAQSIDEIAAETDLAPETVTGAAFALEEAGLVTVEAIERERVALTDEGETYLADGLPEVALYRAALDAGADEEPISLGEVIGAAGLGGNAVDIALANFARKGYGSIDDGAVSADPDADPDADEEAQALAAVAGASDTADDEGDDAEIGGATDPEYKMEEISDEEFIDQIAEVSETAERTYHDDLDNDPGTSNDLDVDADTIDDLERRGLLERSETTERTVLLTDDGVTALMEGVSEAETVGQVTPELLTSGEWEASEFAAYNVEAEAETPHVGRTHVLRQTIERVKDVLVGMGFEEMQGPHVDADFWINDALFMPQDHPARTHWDRFAMETPSRIESLPEDLVERVERAHREGVGDDGDGYHSPWDEDFAEALALRGHTTSLTARHLAGEAMGDLEPPQRFFSVEKGYRNDTLDATHLLEFFQIEGWVMAEDLSVRDLMGTFEEFYAQFGITDVQFKPHYNPYTEPSFELFGEHPETGELIEIGNSGIFREEMLEPLGVDCDVMAWGLAGERLAMLVTGAEDIRDIHGTLTDLDFLRNAEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWU3</accession>
    <name>R4VWU3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase-like complex subunit J2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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            <dbReference type="EMBL" id="AGN00716.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="95" mass="9639" checksum="1584ABD71F0CE999" modified="2013-07-24" version="1">MVPGLVAVALFAVMAWVFLGASFGEAAGFPGGASVIDTIGYALMDANQTDIPTEGFMAALIIIALVLDAALDGAIHLARRDDEGDTVTALGGDDE</sequence>
</entry>
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    <accession>R4VX00</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11155" checksum="969E2CD947BAF407" modified="2013-07-24" version="1">MEVSPSVADRTPYRRDGSRHWSLGATVAIAAGLEPGVVVGASGLRREVAATTRVDLVRALAKRGDLAAERAFVGGVEGYEVLADPRESLADTGQRVSPRRRRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX09</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="32"/>
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            <begin position="44"/>
            <end position="62"/>
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        <source>
            <dbReference type="EMBL" id="AGN01750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="63" mass="6315" checksum="9207D2F7B70C64C6" modified="2013-07-24" version="1">MRITLSEARESPVAAAIFGLGVAAAVVAVFFGDGEFDAALGSPLFLVGAGFAAVAVLVTLAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX81</accession>
    <name>R4VX81_9EURY</name>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="23612" checksum="E2308A31F82C9893" modified="2013-07-24" version="1">MEFTSPVAEFPLGSVFENLPGVTVELERLIPHETLIIPYFWVRGADTDDMEAAFEPHAGVSNIRLIDSIEDEYLMRAEWEQEYFGILSALAEANVVVLSGTGTKEEWRFEVRGESQETLAAFREYCQENDIPIAITAVHAMLPIQGEGYELTETQREALVLAYERGYFDSPREASLQEIADEIGITQQSLSSRLRRGHHRLIGATLSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXH7</accession>
    <name>R4VXH7_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="80" mass="8121" checksum="36D30AB28F59CC54" modified="2013-07-24" version="1">MKELLGDSVAELLAVLLTAVGSGALAIGGAVIEYAAFGNLLTGHATIGAWELVLGGLLLYAGVYLLGYQRLGRSLATSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI1</accession>
    <name>R4VXI1_9EURY</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1333523.L593_05085"/>
    <dbReference type="EnsemblBacteria" id="AGN00966">
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    </dbReference>
    <dbReference type="GeneID" id="16181208"/>
    <dbReference type="KEGG" id="sali:L593_05085"/>
    <dbReference type="eggNOG" id="arCOG10133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="15514at2157"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="476" mass="51074" checksum="C82AB855BFFA880F" modified="2013-07-24" version="1">MTDDDSDDTTSDSFAHRGRDDAPWQRMGRRDLLRIGAAGAATAIAGCSEGDGDDGGTEPSPDAPPSADDDADDGPESIPYADEYDTVVDVVADAGANPDGEESIIPVLEANASSDTLLFFPPGEYLMDGRWLLPSFEHLGLVGDEATIRPPRDYFGYLFIFGLQDSGASDVLFEGIDFDFTAANTAPRPLQAQVDDGITVRNVTVEGTSGTARFDVTTPQGSGVVSNLTMPDGMEIVETLDIPENGGNPDGVGVLVGPANRGRLRFEDCHVEGFPGNGLYASPSNGPIEVSGGLFANNGIASVRVSSPATIRNVEVRCDEAPQGFRNMRGIRLRHGESVLVENCRIVMRDLTYSDGGLVIEQQMESATIRDLEIDSSVDGIPAIHVKSPNHEQPDAEIEFERVQVTGEAGQGSAVQISDRHDCRLNAFDIEQSGPDRNGVYLVRTTDSVLRDSNIEVTGEPVVLEESELRQRNNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXW3</accession>
    <name>R4VXW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446000.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05785"/>
    <dbReference type="EnsemblBacteria" id="AGN01106">
        <property type="protein sequence ID" value="AGN01106"/>
        <property type="gene ID" value="L593_05785"/>
    </dbReference>
    <dbReference type="GeneID" id="16182549"/>
    <dbReference type="KEGG" id="sali:L593_05785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1184"/>
    <dbReference type="eggNOG" id="arCOG00090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_4_1_2"/>
    <dbReference type="OrthoDB" id="54766at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="26148" checksum="39E7E1C6DE42A777" modified="2013-07-24" version="1">MTRPRLVVLDASHGNEDTRRNFRRELDADLVEYDVTAGDVPASGAEFPDVDGVVVTGSRASVYWDEPWIPDVKDWAAEAADRGLAILGVCWGHQLLADVLGGEVAAMDAYELGYVTIVRTTDDSRLLDGIDESFTAFATHSDEVVSLPHGAELLAENDRSIHAFRSGDVFGVQFHPEYDRGTARRVTEGKRDGEASDERVDQALASIDSDAYAAACETKRLFENFLAIVDDRRVSTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYC6</accession>
    <name>R4VYC6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446115.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06370"/>
    <dbReference type="EnsemblBacteria" id="AGN01221">
        <property type="protein sequence ID" value="AGN01221"/>
        <property type="gene ID" value="L593_06370"/>
    </dbReference>
    <dbReference type="GeneID" id="16181714"/>
    <dbReference type="KEGG" id="sali:L593_06370"/>
    <dbReference type="eggNOG" id="arCOG10716">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850716_0_0_2"/>
    <dbReference type="OrthoDB" id="135947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021671">
        <property type="entry name" value="PD(D/E)XK_Endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11645">
        <property type="entry name" value="PDDEXK_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_5" evidence="1">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="16025" checksum="DD1CD5C1E05B9DDB" modified="2013-07-24" version="1">MSRNAGHVDGELAEFAVAADLVAKGCRVSYTHGQYKYDLIADRDDELLRVQVKKANQDNDKPWKYRIFTDRYEEGDVDLFAGYIPALEETFYTTFEDAGSRFRINTKSREQLIPENRSQAKLLDDFTFERAVTELERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYH4</accession>
    <name>R4VYH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447204.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11835"/>
    <dbReference type="EnsemblBacteria" id="AGN02310">
        <property type="protein sequence ID" value="AGN02310"/>
        <property type="gene ID" value="L593_11835"/>
    </dbReference>
    <dbReference type="GeneID" id="16181431"/>
    <dbReference type="KEGG" id="sali:L593_11835"/>
    <dbReference type="eggNOG" id="arCOG06214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147793_0_0_2"/>
    <dbReference type="OrthoDB" id="111150at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="103" mass="11155" checksum="C27C9502A4E89A94" modified="2013-07-24" version="1">MESVTASLATRARSIFDDLGYTVVGEGSEFRAERDWKVVRVTATDGEANPDDEGLHCYVTPSEQVGTLRRRLAGGDSEEWAIIAIDGEDYEVVRAPPGPATPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYK3</accession>
    <name>R4VYK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid ABC transporter periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446205.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06820"/>
    <dbReference type="EnsemblBacteria" id="AGN01311">
        <property type="protein sequence ID" value="AGN01311"/>
        <property type="gene ID" value="L593_06820"/>
    </dbReference>
    <dbReference type="GeneID" id="16181525"/>
    <dbReference type="KEGG" id="sali:L593_06820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1393"/>
    <dbReference type="eggNOG" id="arCOG01021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_5_0_2"/>
    <dbReference type="OrthoDB" id="23746at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="75"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="46137" checksum="1B65B32BE814DBBC" modified="2013-07-24" version="1">MARRYDRRTILKGTAAGITITLAGCLGDDGGDDEDGDADGADGGDGDGNMTDGDGTDGDGDGDDTAVPGSEAGRTVSVGVLQPVTGDLGDLGGPIRDAAILPGAQLEGETDFEIDIRDEDTESTPEAGISAAESLANAGYPAVTGAASSAVTQNVAQSVFIPQGIVGCSPASTSPAITNLDDDDLIFRTAPSDALQGEVMAQVAYEDRDLQSAAVFHLNNEYGELLAESFASAFEEIGGSVQTQTAFEAEQPSYTSALDSTLSDDPDLLVVIGYPASGTQIFRDYYSDFDAERTVMVTDGLQSSDLPGNVDNPMENVLGTAPLASGPNVDAFNQLYEDEYGQAPGVFNAQAYDATAILLLANVAAGENDGIAIRDQMRAVANPEGMEVGPSNLAEGIATVAGGEAVNYQGASSPVTFDENGDVVAVTYSIWEFGEGGAIEQIETVDFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYP3</accession>
    <name>R4VYP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor box histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446250.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07045"/>
    <dbReference type="EnsemblBacteria" id="AGN01356">
        <property type="protein sequence ID" value="AGN01356"/>
        <property type="gene ID" value="L593_07045"/>
    </dbReference>
    <dbReference type="GeneID" id="16182247"/>
    <dbReference type="KEGG" id="sali:L593_07045"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1440"/>
    <dbReference type="eggNOG" id="arCOG02365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="403"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="476"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="525"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="658"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="874" mass="94515" checksum="F4511A43F989C283" modified="2013-07-24" version="1">MSSSVDVADCSVLVVAADDGLAATCRDRLEGWGSFQITTAASIRAAIEHLDAAGGVDCVVTDHDAPDVDGIALLEAVRARSPELPVVLFTDAGSETVASRAISAGVTEYVVRGEHADEWDRLATVIDDAVRYYREHATVADPEAQVTTLLDAARDTIALVRDGRIEYCNQAGTALFGLESTEAAIGVHVGELLSLDDAASADGRDLVDRIAAVQAGEDRLDGVDATLAVDAGLDVGASSVTAAEAALEVTATKVSWLDPPAAALVVRDVTDRRVLADDLALKERAMDDAPVGITIADATRPDEPLVYVNEAFERITGVPVEEAVGRNCRFLQGEGTREEPVAALREAIEAEEPVTVELRNYRRDGTEFWNRVTIAPLFDDEGSVSHYVGFQQDVTERKTTERSLERFRRAVEAAGHAVYMTDPDGTITYVNPAFEEITGYDAEAAIGRTPEILNSGEMPSSYFEALWESILDGEVWSEEVVNRRASGELYYGQQTIAPITDADGEVSAFVAVQIDVTEQKEREERLRHYERAIEGASDLIAAVDTDLEYLFANEAYRTFHGLEGVDLRGVGLETVLPDVLDADEKEDVLRHVRAVLDGETVHYQMTRTDATDTAKTFEIHYYPLEPLGADEIVGVVATMRDVTAQREREQQLVVLDRLLRHNLHNDLNVVLGYAETIAAETSGDLEHGAEQIVVSARRLLDQADKQREIVDLLADPPSHEAVDVVSAVRRVVANASADHPEATLAVEAPDEVVLRTVPALERAIEELVENALVHDDGDAATVRVSVVDAEDAVEVRVADDGPGIPEAERAILDGEEEIDPLLHGSGMGLWLVDRIAGRAGGSVQFEACDSTGSVVTIVLPRSEDEALPREIADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYY9</accession>
    <name>R4VYY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_12705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12705"/>
    <dbReference type="EnsemblBacteria" id="AGN02480">
        <property type="protein sequence ID" value="AGN02480"/>
        <property type="gene ID" value="L593_12705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2607"/>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="502" mass="53629" checksum="E9F1FE4A38521EE8" modified="2013-07-24" version="1">MALTGTVCKYLAITMVVPLLTAIVYGGDLLVFVGTMTLTVGIGLLLERIEPQPDLGAREATLLVTIVWFVVAVVGAIPFVLAGWGTESTLAHPVNALFESMSGFTTTGATVMGDISFDQHSRALLMWRQLMQWLGGMGIIVLMVAILPELAINGSQLLQAEAPGPELQKLTPKIAETARVLWLVYFGFTIVYVALLYSLHLLGFAPDMTFYMALSHGFTTLPTGGFSPEADSIAAFSAAVQWVVIPFMVVAGTNFALFWATIGRNRRALVEDTEFRAYAGAIAVFSALASATLYLGTAPPLGALGGVTEGIAGDALRHGTFQIASLLTSTGYATSDFASWGPAGQMTLLIAMFVGGSAGSTGGGIKVIRWVIALRAVRRELVTSAHPDAVQPVRLRGRVVDEDAVRGVLVFTFLYIFVFGIATLLLTLDAARIGYELNGYEAISASLATLGNIGPGFGSLGPFGSYLEFPWTSKLLMVFLMWFGRLEIIPVLLVFSGSFWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ63</accession>
    <name>R4VZ63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome-c-aa3 oxidase assembly factor CtaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_07980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1635"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
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        <property type="term" value="P:heme A biosynthetic process"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="28751" checksum="E21B9F16E38C7ABA" modified="2013-07-24" version="1">MTLRSRLEASTPSLASIAVATTALTFVLMLLGIWTAVGGYGLTCNGRWPICDGAVFGLFPANFGSFVEWFHRLVAMITGFAIMGTAIAAWRGGAERRVRAAFLLALVITPLQIVLGALTVTTYERLILALHFGSALTILALLVAGTAWTVEDIPSIDRLAAIAALALPPALLLTPGVFVDFLLELHLLYNALGLGAFVALFLASLGARTHSELPRLAAGVGAVATALALIVGRVRLDATGQATILLGLGIALAMALATILLSRRAAGIEGSIGSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZF3</accession>
    <name>R4VZF3_9EURY</name>
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        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447544.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13555"/>
    <dbReference type="EnsemblBacteria" id="AGN02650">
        <property type="protein sequence ID" value="AGN02650"/>
        <property type="gene ID" value="L593_13555"/>
    </dbReference>
    <dbReference type="GeneID" id="16182213"/>
    <dbReference type="KEGG" id="sali:L593_13555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2775"/>
    <dbReference type="eggNOG" id="arCOG00842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352098_0_0_2"/>
    <dbReference type="OrthoDB" id="79594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="211" mass="23888" checksum="6643C148CFFD310F" modified="2013-07-24" version="1">MTNLFPERIETDRLVMEPMHEVDVHRLYEICAEDDGIEDVTEYMPWDPHDTPKETAEFLEHQAEQWEECDSAGYVIRPGKDEDGAGEIAGSTALHVDWDKQLGTIGLWLRKPFWGRGYSGERAGGLLAVAFDHVDLEMVSVTHQAGNEKSRRAIEKYVDRFGGRHEGLLRNFEPANLETGGAVDAHRYTIAAEEFEANRGEPPTVTFDRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZH8</accession>
    <name>R4VZH8_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01656">
        <property type="protein sequence ID" value="AGN01656"/>
        <property type="gene ID" value="L593_08555"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1752"/>
    <dbReference type="eggNOG" id="arCOG03107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
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        <property type="entry name" value="Impact"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0029"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="3">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="23050" checksum="CCBF5883B7A369E1" modified="2013-07-24" version="1">MTDDEPPDVAGSDGGSDGTAEPYETVGERASAAFEVQGSEFIGYVAPVESEQAADDFLAEIEAEYADATHVVPAYRVRTDEGYLREYSSDDGEPSGSAGKPALNVLQGQDLENVAVAVVRYYGGTNLGVGGLVSAYGRATKEAIEAAGVEERLPQARFSITVEYDDSGAVRSVLESADSKFDAAYEERVSFEVTVPVGEAAGLRDRIRSTTSGRAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZL7</accession>
    <name>R4VZL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446585.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08730"/>
    <dbReference type="EnsemblBacteria" id="AGN01691">
        <property type="protein sequence ID" value="AGN01691"/>
        <property type="gene ID" value="L593_08730"/>
    </dbReference>
    <dbReference type="GeneID" id="16182523"/>
    <dbReference type="KEGG" id="sali:L593_08730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1789"/>
    <dbReference type="eggNOG" id="arCOG03142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080186_0_0_2"/>
    <dbReference type="OrthoDB" id="96593at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="251" mass="26709" checksum="B402706E9902E0BB" modified="2013-07-24" version="1">MIVVATEDFEVYHDVVAELRDRDAAFTTVEPGEALPERATVLIVAADEMDDVRAAHPDLGPEVEVVGAEPGEARTAVEAALQLARSEGGQLVVGVDPGDRPGIAVLVGDTVVAAYHVPLAQVAEIVREEVADAPDPIVRIGDGARLQGSRLIDALGDVRVELVDETGTTPSLGAGASGLGDVIAAVNIAQREGEVIEERDVEPTVGELRRIQERSRERGEDNRAIDELLARRVASGELTVEEALDTHREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W010</accession>
    <name>R4W010_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447739.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14530"/>
    <dbReference type="EnsemblBacteria" id="AGN02845">
        <property type="protein sequence ID" value="AGN02845"/>
        <property type="gene ID" value="L593_14530"/>
    </dbReference>
    <dbReference type="GeneID" id="16181313"/>
    <dbReference type="KEGG" id="sali:L593_14530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2971"/>
    <dbReference type="eggNOG" id="arCOG07573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177954_0_0_2"/>
    <dbReference type="OrthoDB" id="115366at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10800" checksum="0CF7DD06EE4DF348" modified="2013-07-24" version="1">MPLAQLLEQYVSLGIFILAAGLSVLSFLAWRRERDRRMWIVTLGYAMFAVYGLIVFLEYPLLPYFPYATLELLEHGSAILILGGLLAFFVALTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W022</accession>
    <name>R4W022_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">L593_09405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446720.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09405"/>
    <dbReference type="EnsemblBacteria" id="AGN01826">
        <property type="protein sequence ID" value="AGN01826"/>
        <property type="gene ID" value="L593_09405"/>
    </dbReference>
    <dbReference type="GeneID" id="16182697"/>
    <dbReference type="KEGG" id="sali:L593_09405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1936"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OrthoDB" id="14454at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="48"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="486" mass="54672" checksum="BCA2B9E4844F28B2" modified="2013-07-24" version="1">MSDDDAQELGITESKEHATGEWYAEVVQKAKVADYAPMGGFIVTRPRGWALWEAVQDFLDAKFKDTGVDNAYFPLFIPESYLEREKDIVEGFDPEVAWVTHGGHDELEERLAVRPTSESIIAPFMAQWTRSHRDLPMRLNQWCSVVRWEATETKPFFRTKEFCWQEGHTAHATADEAWEETMLRLDQYEAVYEDLLAIPVLRGRKPEHDKFPGAETTTTVEALMPDGKSVQAGTSHDLGTSFADAFEITYTDEDEEEATAHTTSWGLSWRALGALIMTHGDDQGLVLPPTIAPTQVVIVPIWQEDTREDVLDYSEELAEDLEEAGLRVDLDDRDTRNPGFKFNEHELNGVPLRIEIGPNEVEDEEATLVHRPDGESVVADRDSAVDDVEDALDEVYDKLYAAAEENLEENVREADEPSQILGTIGQHGGYVKCGWCGDEACETVIKDEIAAEIVMVPLDRDEEPIQDDCAICGEESTETAYFARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W076</accession>
    <name>R4W076_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09705"/>
    <dbReference type="EnsemblBacteria" id="AGN01886">
        <property type="protein sequence ID" value="AGN01886"/>
        <property type="gene ID" value="L593_09705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09705"/>
    <dbReference type="eggNOG" id="arCOG09144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100865_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="16093" checksum="24B1D8578B077FEC" modified="2013-07-24" version="1">MVGVSEPGFDSGAPAPGVSATVVPATVAVVAAAVAVPAAALALLGTVSMAVGVRRGTRRLHTTGGALAFGGVLLSAGAGAPPALALIGGAAAIIAWDAGEHAIGLGGQVGSEAYARRGILAHVGASTIAASTIVVVAAIVFVLARTGNPSAATVVLVFAVGLFALLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0J2</accession>
    <name>R4W0J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446935.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10480"/>
    <dbReference type="EnsemblBacteria" id="AGN02041">
        <property type="protein sequence ID" value="AGN02041"/>
        <property type="gene ID" value="L593_10480"/>
    </dbReference>
    <dbReference type="GeneID" id="16180543"/>
    <dbReference type="KEGG" id="sali:L593_10480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2160"/>
    <dbReference type="eggNOG" id="arCOG03095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_11_4_2"/>
    <dbReference type="OrthoDB" id="56785at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="33738" checksum="5E8B4F1AE19618A5" modified="2013-07-24" version="1">MQVAILGCGYVGLELGRQLVERGHDVVGVRRSAQGVATIEDAGFDAVQVDVTDSDALAAVPDVDAVVFIASSGGRGAEAAREIYVDGLRTTIDHFGGRESTPEQLLYTSSTGVYGDHDGDWVDETTPIEPTTEKTAVLAEAERIATEVAAEHGMDGSVVRFAGLYGPDRYRLERYVEGPVTEGYLNMIHRDDAAGIVRFVLEETADRRDGDSDSWPDPLLPNDVLLAVDDEPVSKWAFADWLAEECGEPAPEKRTIEERLATGDLSEPAERRLRTSKRCSNDLLHEVGYELAYPTFREGYRQAIEAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W172</accession>
    <name>R4W172_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447210.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02316">
        <property type="protein sequence ID" value="AGN02316"/>
        <property type="gene ID" value="L593_11865"/>
    </dbReference>
    <dbReference type="GeneID" id="16181646"/>
    <dbReference type="KEGG" id="sali:L593_11865"/>
    <dbReference type="eggNOG" id="arCOG09214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032968_0_0_2"/>
    <dbReference type="OrthoDB" id="122565at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="269" mass="27665" checksum="3EC54C43B440FA7A" modified="2013-07-24" version="1">MQLKSALRWSLYDRALALLPFLLGIGIVAAGVWLGAGAFLSEIAFGDPSDAGQPASIPMIAGGFVLGLIVWQLGRSAVRHHTMRKAIENQIDELVDEERIASTAASKVDDRIADVEADVQQVNRKTTRLEQQVRGDELGSDEFGSDDGSAAGGAEPASAAAAGGAASVDSTVDESGPDAIGTDATSEEAVESHTADDTGDDAQAAGTGSAAAGSDDPAETEAGSEAGEDGPSDGVEEPTSDDESEADDEPDDGFEWEGDTDDGEYYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1F4</accession>
    <name>R4W1F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447325.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02431">
        <property type="protein sequence ID" value="AGN02431"/>
        <property type="gene ID" value="L593_12460"/>
    </dbReference>
    <dbReference type="GeneID" id="16179920"/>
    <dbReference type="KEGG" id="sali:L593_12460"/>
    <dbReference type="HOGENOM" id="CLU_982179_0_0_2"/>
    <dbReference type="OrthoDB" id="142592at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="30782" checksum="CCC187D127E01056" modified="2013-07-24" version="1">MGDDGGSGDGGAGGDSGSDGDDAGAAGHPFDVQAFEFTRRRARHFDDYTPQPDATYRARDTVWIYVEVSNVTPVASGPELDSSWEFVSPSGEVVLSTEQPLRFQAGTLGELPNEGFVTQGIDLTAADLPTSGEYTVRMTLTERERDDVVEASNTVSIHMFEFETVAFTDGEPAGDGYDPKPGRTYARGEDVWVYTQVGYAPTDDSGRAVLRYQFDVEAPDGETWNVDDAVEEWERVQEDDLLIYARAFVTSTDDPAGEYTMTITVSDVNGGARIETTETFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2D4</accession>
    <name>R4W2D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) iron-sulfur domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447730.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14485"/>
    <dbReference type="EnsemblBacteria" id="AGN02836">
        <property type="protein sequence ID" value="AGN02836"/>
        <property type="gene ID" value="L593_14485"/>
    </dbReference>
    <dbReference type="GeneID" id="16181261"/>
    <dbReference type="KEGG" id="sali:L593_14485"/>
    <dbReference type="eggNOG" id="arCOG02851">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_4_1_2"/>
    <dbReference type="OrthoDB" id="102560at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14956" checksum="3F5D7BA97576E038" modified="2013-07-24" version="1">MAAEPTLTTVDHVHEEGSFLFTVADDYGVTQEVILVPCEDGVEAWHNRCTHEDFKLDRGFGVIYREGEIVCAKHGSTFGTCSGFCDNGDAKDTTLPSVEVACEDGDVVLVDDGYTFLHEGAEDDDDGDDVPGSTSNVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Q3</accession>
    <name>R4W2Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444976.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00635"/>
    <dbReference type="EnsemblBacteria" id="AGN00082">
        <property type="protein sequence ID" value="AGN00082"/>
        <property type="gene ID" value="L593_00635"/>
    </dbReference>
    <dbReference type="GeneID" id="16180173"/>
    <dbReference type="KEGG" id="sali:L593_00635"/>
    <dbReference type="eggNOG" id="arCOG06802">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985702_0_0_2"/>
    <dbReference type="OrthoDB" id="125453at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="30739" checksum="ED0F7A59C6C38A00" modified="2013-07-24" version="1">MSRETDRPLWIGLVVLGVALAINSLLGPLAAAVVEYPFSQSMVNQTIGLDAVSLAVVAPWSLLAAEAVRRKHHAGPILAIPPAAYSAYMFSQYVLGPTYLEYPAVMPLHLGIFVLGWVLVVLAWVRIDVSDLPTVGERRWRIYAGGVGFFAFFTFARYVPSFVGMASGEPISEEFAQDPTMFWTIFLLDVGVVVPATIGASVGAYRGRAWGRKALYPLAGWFALVPISVSAMSIVMYLNDDPYGSLGSVAFLTSAAVAFTAFVVWVHLPLFGGDGSPDTGPASETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2Q9</accession>
    <name>R4W2Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monovalent cation/H+ antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00092">
        <property type="protein sequence ID" value="AGN00092"/>
        <property type="gene ID" value="L593_00685"/>
    </dbReference>
    <dbReference type="GeneID" id="16181931"/>
    <dbReference type="KEGG" id="sali:L593_00685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.139"/>
    <dbReference type="eggNOG" id="arCOG01541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
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        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="426"/>
        </location>
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        <location>
            <begin position="473"/>
            <end position="596"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="643" mass="66715" checksum="6F8C187CA99216E4" modified="2013-07-24" version="1">MSTTASLRPLLAVAIPTIAIVLIVATGSSRRNLRDAWSIAAAIGLFATVASMLPAALDGDSFRWSAGAYAPGIEFALQADPLGMLFATLSSLLWVFTAFYAIGYMRGLDESNQTRFFAAFAASLAAAVGIAFAANLLTIFVFYELLSVATYPLVAHDETDEARAAGRKYLLYTFFGGGVLVLGGAVLVYALAGTTTFGATAQGLATADPTLAKAAFAMLAAGFGVKAALMPLHSWLPDAMVAPTPVSGLLHAVAVVKAGAFGIARLVLDVFGPELVGDLGVGLPLAAVAAFTLLTASVIALRQDRLKRRLAYSTISQLSYIVLGLALLGPTAITGGLLHIPAHAFMKLTLFFCAGIIHVETHTDYISEMDGIGKRMPLTMTAFAVAAAGMAGIPLVAGFVSKWFILVGAVEVNEAVFAVALLVSGVLNIAYFWPIVYGAFFEDYDTADEKPLVSGSLGGHVGPRTIQFLKPAGAHHGEESGGALAGSSADDDRGEPAPLEDGEYAVDQNPSDHLPTSAEAAPDGESIDAPVASSAGESGNDSPDSDTVDQDADAADYESDHGHQDADHGHHDADHGHNEADHDHHGGPGPDGWECRDWTGAESTWLMLGPILAVAAGALVLGVVPYQAQFLELVDVIVAGVFA</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN00132">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.182"/>
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    </dbReference>
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        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="40004" checksum="07D5C3718311C31F" modified="2013-07-24" version="1">MHTREGLALSCVACGWQGDRLDAQRCPDCDGQLAPSYDADAIDGSSLRAGLEDSDSQWSVDALVPIGSDGDGVTLGEGATPLVACPTLGDELDVETFEIKDEGHNPTGTVRDRAIAVAATAAVEAGATDVALPTTGADGVAAAAYAARADLDAHVFVPTRSTHTTKAMINVHGGDMQVVEGRLPHAEDAFESAIDEEDGWTPIDPANSPLRAVGPATMGAELFASADGGVPDAVVVPTGHGEVLAGLHAVAELLVDLGILEELPEFHAVQAEGCAPIVRAFEDDEGTVEGWDSPDTISGALEVPDPAFGTHALAAVRESGGRAVAVDDEAILASACRIAAAEGLQASVAGGAAAAGAWELSNAGVFESDDAVVCCNTGAGSLDSDVLRSHLMRAG</sequence>
</entry>
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    <accession>R4W395</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN00392">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG06401">
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            <begin position="1"/>
            <end position="25"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="AGN00392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="7032" checksum="714B266FF9DC1DC4" modified="2013-07-24" version="1">MTTMPETPPSDGTEVEPEERPPEETVDFVETYETDDGIVFYDVDNPLAWLESDQVVPLDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3D1</accession>
    <name>R4W3D1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00457.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN00457">
        <property type="protein sequence ID" value="AGN00457"/>
        <property type="gene ID" value="L593_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.513"/>
    <dbReference type="eggNOG" id="arCOG02178">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF63"/>
    </dbReference>
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        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
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        </location>
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        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="30113" checksum="997ACF20CB9C8180" modified="2013-07-24" version="1">MNPSVTVGAAGSGSLWGPILQAGGLLPEGFGLPPLPYVGALLLGLITVGALLWALSPPVTNATVVAFAPWMMTGGVLHALDQVREFPDYVEPLFGTPAVYATVALAAGTVWVITTLYSAMTAGTPDRHLGAIGTGTAVTFAIFGLIEAFNAGTLDTLPAAITIAVTGVVAAITWAIIGVRFTDSAALASWSGVVVVVAHALDGVSTAVGYDMLDVSERSPVSEAVLEAGAALPTAEFVGAGWLFVLVKLIVATGIVVLMREWIRDAPQEARLVLLLVAAVGLGPGTNNLMLFAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P6</accession>
    <name>R4W4P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446141.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06500"/>
    <dbReference type="EnsemblBacteria" id="AGN01247">
        <property type="protein sequence ID" value="AGN01247"/>
        <property type="gene ID" value="L593_06500"/>
    </dbReference>
    <dbReference type="GeneID" id="16180878"/>
    <dbReference type="KEGG" id="sali:L593_06500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1325"/>
    <dbReference type="eggNOG" id="arCOG00261">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_0_2"/>
    <dbReference type="OrthoDB" id="54799at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="36951" checksum="2BD6F0AD9B26AD8E" modified="2013-07-24" version="1">MKYLSMTNQRLMALASVLGVVVLWFVGRLFPETVVGEIFTTGMVARSLRLSVPIALAAVGGLYAEKSGVFNIGLEGLLIFGAFTAAAVSWELGGSQISQLDLWIAVLVAMAVSAAIAAIFAVFTIRYKANQIVAGLAIWFLGLGFAPFAAIVLWDRVNSPSLNGIDTIVVPGLSEIPLLGPVLFEASPFVPITVGIVILAYLVLYYTRWGYWVQAAGENPEALDTAGVSVNRVRYASVIFSGVLCGLGGAALSIGFSEGFVGRGVTMVDGRGWIAIVAYLFGNYNPLGAFGASLLFGGVNALQIQLQTIGVSIPNRLSGLFPYIAVLIVLAFVGGTRIPSAAGEPYETESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5D4</accession>
    <name>R4W5D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446561.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08610"/>
    <dbReference type="EnsemblBacteria" id="AGN01667">
        <property type="protein sequence ID" value="AGN01667"/>
        <property type="gene ID" value="L593_08610"/>
    </dbReference>
    <dbReference type="GeneID" id="58789360"/>
    <dbReference type="KEGG" id="sali:L593_08610"/>
    <dbReference type="HOGENOM" id="CLU_1640038_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="161" mass="16802" checksum="E30E96DD886A964D" modified="2013-07-24" version="1">MQPGLSEVARDVEADPAAVFEAHDAESVEELVTGAGAPERDATSDRAVRRLFEGDLDRPERRSTTEEPSGGVPSTGDPSSRASACGVEDGSAGESTTTPAVLVELERAIDEAEEPAAVDGDDFDALDDEVADALAVAEELDEADAGEADLESSVPEEWQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5J6</accession>
    <name>R4W5J6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446656.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09085"/>
    <dbReference type="EnsemblBacteria" id="AGN01762">
        <property type="protein sequence ID" value="AGN01762"/>
        <property type="gene ID" value="L593_09085"/>
    </dbReference>
    <dbReference type="GeneID" id="16182616"/>
    <dbReference type="KEGG" id="sali:L593_09085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1863"/>
    <dbReference type="eggNOG" id="arCOG04284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_0_0_2"/>
    <dbReference type="OrthoDB" id="66943at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="26118" checksum="649D6DF57C9DD3CE" modified="2013-07-24" version="1">MSRETPAPTIGQVALIALFVTSLVTAQLTATKLLAFDLPVSLPIVGAAIVLPGAALAYAVTFLATDCYTELYGRRPAQVLVNVGFGMNFVLLALVWSTILAPWAGYGVPAEQFETVLGAGTNIVIASLAAYVVSQNYDVLAFHWIRDRTDGEYLWARNIGSTASSQAIDTVIFVVLAFGILPRLIDVGQVTSWDLVFELIVGQYLLKLLIALLDTPVVYGVVGAIRRQEASEQDATDALAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5N0</accession>
    <name>R4W5N0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446731.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09460"/>
    <dbReference type="EnsemblBacteria" id="AGN01837">
        <property type="protein sequence ID" value="AGN01837"/>
        <property type="gene ID" value="L593_09460"/>
    </dbReference>
    <dbReference type="GeneID" id="16182715"/>
    <dbReference type="KEGG" id="sali:L593_09460"/>
    <dbReference type="eggNOG" id="arCOG01083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125804_0_0_2"/>
    <dbReference type="OrthoDB" id="129787at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="19864" checksum="53C5FB862A7D5424" modified="2013-07-24" version="1">MTRATDRDASSHDGLQIDSLTDPATLTERDDVPVSQDEMEHESADHCSTDIAGRVAVGVTNDDGQTLLLCNEEHGVALLPHGSVQPGEDWLVAARREIEAQTGVEIALDGIELLRDIDHVIAGEDGVHTSTYGLIFTATPAGGDIQDCKQSADAGSDRWYAGWFDGVPEHLDVPPGGPGDDLELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5N4</accession>
    <name>R4W5N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446741.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09510"/>
    <dbReference type="EnsemblBacteria" id="AGN01847">
        <property type="protein sequence ID" value="AGN01847"/>
        <property type="gene ID" value="L593_09510"/>
    </dbReference>
    <dbReference type="GeneID" id="16182738"/>
    <dbReference type="KEGG" id="sali:L593_09510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1958"/>
    <dbReference type="eggNOG" id="arCOG04612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082927_0_0_2"/>
    <dbReference type="OrthoDB" id="60415at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016757">
        <property type="entry name" value="UCP019322"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09883">
        <property type="entry name" value="DUF2110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="27025" checksum="C28343B46868D757" modified="2013-07-24" version="1">MAEAVVLARKIYVAGDARERTLRSLRGQIGNHLSDLDASFEIELREDGFPIVTLEGEDAVVARNLLAETFDEIPTSADGASGDGEQEATGPFDPEETYTGTLESWDENGFVLDAGVPVRVPPSEIELGPGNPEQIVERFGLVQHLPMQFQVTGERWEGDADGPFVAALADAERDRLYEWQRGPGRVTVNSATRSEVRATVNRAGHAQDIVTVERLGLLEQSIVCTEDTDPPGLIASIGEYLPAELRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5N7</accession>
    <name>R4W5N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline dehydrogenase-like flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446746.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09535"/>
    <dbReference type="EnsemblBacteria" id="AGN01852">
        <property type="protein sequence ID" value="AGN01852"/>
        <property type="gene ID" value="L593_09535"/>
    </dbReference>
    <dbReference type="GeneID" id="16182746"/>
    <dbReference type="KEGG" id="sali:L593_09535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1963"/>
    <dbReference type="eggNOG" id="arCOG02233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_1_2"/>
    <dbReference type="OrthoDB" id="43345at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
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        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
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        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="419"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="549" mass="59089" checksum="741C8AB6CD4F09D9" modified="2013-07-24" version="1">MTGSAQADGRDASDRTAGRSADPDRSPVANADVCVVGAGPAGTLVADRLAGRDHEVVVLDAGPRFDETERVERMEKAIRPAFSRPDVWDVGGDRDAYESVGDRHYPLNRTRVKGIGGSTLHWQGMVMRLHEADFASASERGVGANWPIEYSDLRPYYAEAETGIGVAGADDNPFAPPREEPFPMPAFPPSYSDSLFAEACEALEISMHSVPNARNSEGYDGRSACQGYGSCRPVCPSGAKYDGSVHAETAAAKGATVIDRAPVQRLEHTTDRIEAAVFATPDGTEHRQEAETFVVAAGGVETPRLLLLSDSEHYPDGLANSSGAVGRYFMDHVFAGAGGVLEEPTRQNHVGFLTSESHQFYDEADERIAPFKLEFFNFAGPSPVGIALTGEDWGDDLLERIRAEYGNHVTVGALVETLPQAENRVALHPDRTDDHGNPVPEIHWSIDDRAKRTIERANEVQHEILDELGASERWTQGVEGTVPTNHHMGTTRMGSDPSASVVNSSLRTHDLENCWIASSSVFPTAGAMNPTLTIGALALKAADHVDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5R5</accession>
    <name>R4W5R5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Globin</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_09760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446791.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09760"/>
    <dbReference type="EnsemblBacteria" id="AGN01897">
        <property type="protein sequence ID" value="AGN01897"/>
        <property type="gene ID" value="L593_09760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181898"/>
    <dbReference type="KEGG" id="sali:L593_09760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2009"/>
    <dbReference type="eggNOG" id="arCOG06333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103526_2_1_2"/>
    <dbReference type="OrthoDB" id="104638at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="13672" checksum="142E2D499FC0F42A" modified="2013-07-24" version="1">MTEETLYDRLGGQDAIAAVVDDFYDRLVADPDLGPFFDDADLERLRETQTDFLCEAAGGPETYDGPSVRDAHLEVPFEPAHIERAVELLYESLDEYDVEGEDADAVVGAVAQFEAELLASPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A5</accession>
    <name>R4W6A5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01475"/>
    <dbReference type="EnsemblBacteria" id="AGN00248">
        <property type="protein sequence ID" value="AGN00248"/>
        <property type="gene ID" value="L593_01475"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.300"/>
    <dbReference type="eggNOG" id="arCOG02098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850715_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="15618" checksum="F1723A314C336D4F" modified="2013-07-24" version="1">MTEHSRTDDANGEQTEPIERLLADEGESSGARPSSPQLRSDGGEHEGMQDMSLDELREEIESIDRELVELIARRTYVADSVAAVKDEQDLSTTDEEQEQRVMDRAGKNAEQFDVDANLVKAIFRLLIELNKVEQRESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A6</accession>
    <name>R4W6A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445147.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01500"/>
    <dbReference type="EnsemblBacteria" id="AGN00253">
        <property type="protein sequence ID" value="AGN00253"/>
        <property type="gene ID" value="L593_01500"/>
    </dbReference>
    <dbReference type="GeneID" id="16179833"/>
    <dbReference type="KEGG" id="sali:L593_01500"/>
    <dbReference type="eggNOG" id="arCOG13694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827986_0_0_2"/>
    <dbReference type="OrthoDB" id="63694at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="42340" checksum="E5088A66FA6AAE1B" modified="2013-07-24" version="1">MTQPPSSGTGHSGDASVDGDSLGGDSTRGASSGDESFTDTARDRLAGSGVLDDLRDDDGEIALGRREALAYAGGAGVGLGGWKALHNVVLGYGVLAGTNVRDQDTAALVDQHFEVRSGVTAVSGYEVWSDGDSVGVYTDGERLDGVTIDDDAGTAERIDATYGLDGSPVAQLQADMRALADNEVSYEFFQTDEFLERVTSAAARPFTVDALRGPVFDSPDAEFVGEFADVDPRDAGGLVQGLKDGFREYSYYDVPRYAAGSVEDNILLGAVDLRKFFESPTDFHALANGENSGLFCTELVNRSIEAFHTVPATEQSPPIVAGCVYDERHKHSYTVLASAIRDDDQLVIPATFVDYTHSTLYDDLHLRWLLGEGVEAYNDRHRVTEIFWNSYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E1</accession>
    <name>R4W6E1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Archaeal Lon protease</fullName>
            <ecNumber evidence="13">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent protease La homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L593_01885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="13"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445222.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01885"/>
    <dbReference type="EnsemblBacteria" id="AGN00328">
        <property type="protein sequence ID" value="AGN00328"/>
        <property type="gene ID" value="L593_01885"/>
    </dbReference>
    <dbReference type="GeneID" id="16180814"/>
    <dbReference type="KEGG" id="sali:L593_01885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.383"/>
    <dbReference type="eggNOG" id="arCOG07556">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392630_0_0_2"/>
    <dbReference type="OrthoDB" id="7657at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="15">
        <location>
            <begin position="270"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="16">
        <location>
            <begin position="565"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGN00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="776" mass="83414" checksum="DA9096DC3A240D91" modified="2013-07-24" version="1">MSKDTEPEDEPSDPGADDGGAAPVADEPDGGGDEHRAEEADGPSGDGSEAERGEGSGAPTSDGADAPGTDQPAQHGDGGATDETNHGQEDSDLPTWEERFGDADDTDLEEGVAFPQEEGPEKMSEAGGEALGKDVEQDLIADEFDPDDDDLLGGLDIESTDEIPIPDRLVDQVIGQDDARDIVIKAAKQRRHVMMIGPPGTGKSMLAKAMSQLLPKEELQDVLVYHNPDDGNEPKVRTVPAGKGDQIIDAHKEEANKRNQMRMFLMLIIVAIILGYTILTPTNILLGLIAAIAVYFVFRYMQRGSDANIPNMIVNNADQTVAPFEDATGAHAGALLGDVRHDPFQSGGMETPSHDRVEPGAIHKANKGVLFVDEINTLDIRTQQKLMTAIQEGEFAITGQSERSSGAMVQTEPVPTDFVMVAAGNMDAMENMHPALRSRIKGYGYEVYFEDTIEDTPEMRRKYGRFIAQEVEKDGRLPHYTREAAEEVVLEAKRRAGRKDHLTLKLRNLGGLVRVAGDIARAEDADVVTREHVLRAKKRSRSIEQQLADEIIERRKDYELRVSEGEVVGRVNGLAVMGGDSGIVLPVMAEVTPAHGAGETIATGQLKEMAQEAVQNVSAIIKKFSDEDLSEKDVHIQFVQAGRQGVDGDSASITVATAVISALEDMPIDQSLAMTGSLSVRGDVLPVGGVTHKIEAAAKAGMDRVIIPAANEQDVMIEDEYKEMIEIIPVSHISEVLDVALIGETEKDGLVERLKSITGSALDKQVGSGSGSPSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J0</accession>
    <name>R4W6J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447251.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12070"/>
    <dbReference type="EnsemblBacteria" id="AGN02357">
        <property type="protein sequence ID" value="AGN02357"/>
        <property type="gene ID" value="L593_12070"/>
    </dbReference>
    <dbReference type="GeneID" id="16182020"/>
    <dbReference type="KEGG" id="sali:L593_12070"/>
    <dbReference type="eggNOG" id="arCOG06415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202923_0_0_2"/>
    <dbReference type="OrthoDB" id="123772at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6464" checksum="60B283E700C265AC" modified="2013-07-24" version="1">MSVSGLCEICEQAPAVDRCERCGAVVCREHLAERLGFCTRCAAEVQGGDPTPGEGGDTFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q2</accession>
    <name>R4W6Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MlrC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445407.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02810"/>
    <dbReference type="EnsemblBacteria" id="AGN00513">
        <property type="protein sequence ID" value="AGN00513"/>
        <property type="gene ID" value="L593_02810"/>
    </dbReference>
    <dbReference type="GeneID" id="16181189"/>
    <dbReference type="KEGG" id="sali:L593_02810"/>
    <dbReference type="eggNOG" id="arCOG09072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028172_2_0_2"/>
    <dbReference type="OrthoDB" id="19901at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1485" evidence="2">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MlrC_C" evidence="1">
        <location>
            <begin position="298"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="476" mass="50593" checksum="FB7EED1985A1E763" modified="2013-07-24" version="1">MRIAVATVKHETNTFADGSTEFEDFEVATDDALLGSFATGRSIAGIRDALLAADADLLPTIGTDAIPGPTVTDAAFERFRDELLDRIEGEHLDGVCLDLHGSMHAEHYPDPEGALVAAIRETIGPDVPITAALDMHATITERLVEQLDGVAGYRTAPHTDVVETGERAASLLLESVRDDRELTLGWERLPMLLAGERSETEAAPMASLIERCRSADEESGILDANYFLGFPWADSPHAGCHALVTGDASDEASVESTATELAEAFWDRRDEFAFTTEAYDPETALDEAAATTDGPVVVADTGDIPGAGGSEDVVDFLQTVTERSAFDDPLVAVIADPDAYDTCASAGDGETVDLALGQAAGSGEPYDTAADVREVATVDGVGTARVVVDGTTVLVTEERTNVHRDPANLRDVGIEPTARDLVVLKSGYLSPAWKALAGRRLFALTRGNTDQVLSELPYERVPRPIAPIDEETGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6V5</accession>
    <name>R4W6V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445487.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03210"/>
    <dbReference type="EnsemblBacteria" id="AGN00593">
        <property type="protein sequence ID" value="AGN00593"/>
        <property type="gene ID" value="L593_03210"/>
    </dbReference>
    <dbReference type="GeneID" id="16180461"/>
    <dbReference type="KEGG" id="sali:L593_03210"/>
    <dbReference type="eggNOG" id="arCOG02565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027478_0_0_2"/>
    <dbReference type="OrthoDB" id="25777at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="439" mass="46663" checksum="C6DADFDC4AF1AF34" modified="2013-07-24" version="1">MRRRDVLAGLAGAAGAIGVYGAASVLTSGDPGSYEPLGSVDLEGTRELVSSDDGSTAFLAVDDGIATVDCSTPSDPTVLAERRGVLADDPDGPLGLVWDVSLSGDRLLAAGPAQPVPGSALQAALLFDVADPADPQLLDVYSTEFPIHNCYLEDGYAYLTAYDGEGNPLVICDAGDGVLTEVGRWSLFDHDPAWSDVHTALRQLHDVTVQDGVAYLPYWDAGTYLVDVSDPTAPSYLGHTSVRGRSAMTDVGLVEIQRGLLAPPGNSHFVTPDESGDLIAVGREAWAVPQGDCSVGGPAGIDLYDASDPTEITHHATIDPPESYANTRSGWFTTAHNVDLRDGRCYSSWYFGGVKVHDVSNPGAPEELTWWRKPEETSFWTAQHAVPGEYFLASSADDAAGYADSIPGRVYVFPDREGRQPNAPELTAPPEGEQRLREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R4W770</accession>
    <name>R4W770_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">L593_13840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447601.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13840"/>
    <dbReference type="EnsemblBacteria" id="AGN02707">
        <property type="protein sequence ID" value="AGN02707"/>
        <property type="gene ID" value="L593_13840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181863"/>
    <dbReference type="KEGG" id="sali:L593_13840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2832"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OrthoDB" id="33372at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="190"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="323"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="436" mass="48905" checksum="D45D0292F8945FA3" modified="2013-07-24" version="1">MSATDRAVVAKRADAGEPETEEIEHLARSAGYEVAAVVTQTRTEDPALEFGEGKAEELARIVEREDADTVLFDNELGPYQTYNLGQLLPKGVEVLDRFTLILEIFGQRAETRTAQLQVELAELRYELPRAEAKTSLAKREEHPGFMGLGEYDESREQDIKSRISRIRDELDQIEQTEQHRREQRRESGFDLVALAGYTNAGKSTLLRRLAEELDVDENEELHQDLESTAESEDQLFTTLGTTTRRADFEGRDVLVTDTVGFISDLPHWLVESFKSTLDAAYRADLVLLVVDVSEPVESIREKLVTSHDTLYERNEAPIVTVLNKADLVDDEELERKREALSALAPNPVAVSAKEGLGIDELSERVRLALPPLEEERLVMPMTDDTMSVVSWLHDNARVDDVTYGDDDVLVEFAARPAVVEQSRSKAEALQPRAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H0</accession>
    <name>R4W7H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445857.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05070"/>
    <dbReference type="EnsemblBacteria" id="AGN00963">
        <property type="protein sequence ID" value="AGN00963"/>
        <property type="gene ID" value="L593_05070"/>
    </dbReference>
    <dbReference type="GeneID" id="16181198"/>
    <dbReference type="KEGG" id="sali:L593_05070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1035"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="543" mass="58156" checksum="C2B3E6A4FB28F42E" modified="2013-07-24" version="1">MTADAERADLTGGDDGAGGAERAFVLGLDGVPWDLLSEWAADGDLPNVARLIEEGAAGPLESTTPATTPLAWPSIATGVGPDKHGIYGWRDLSPSYSHRMYTANDVAGPFLWDVLSPAVVGNVPMTYPARSIDGAMVAGLMTPDLEDEGFTAPDSLAAEIRSEIPDYEIGLYWEDYEGDTPEFRADLQSLVENRRRLMHHLLEREPWRLFFFVYTAPDRLQHLVWDEAVLLEHYRYLDEIVGEAIAAAEANDATLYVVSDHGFGPVETTVAPNRALADAGFLTGREGSGGRGALERFGVTRERVLGALDRVGVDQQTLLSHLPRSVVDSVAERIPGNNVLYDVDFEQTQAFAHGPGNVYINDTERFESGVVAPADVPDVRAAVADVLSGITDPATGEPVLEVLDGDGAFPADDASPDIAIEGRDGYEVVNSWQDTDVLSEAGRMAAGHRMDGIVLAWGPSIRAGATPEDASVYDLAPTLLHDLGEPVPDRVDGRVLTELFEPGSEPATAPVETAAYAADGTEASVAEDMGAVEDRLKGLGYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I3</accession>
    <name>R4W7I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447821.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14965"/>
    <dbReference type="EnsemblBacteria" id="AGN02927">
        <property type="protein sequence ID" value="AGN02927"/>
        <property type="gene ID" value="L593_14965"/>
    </dbReference>
    <dbReference type="GeneID" id="16181512"/>
    <dbReference type="KEGG" id="sali:L593_14965"/>
    <dbReference type="eggNOG" id="arCOG00143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_6_2"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="392" mass="40435" checksum="E4CF93E863E1D4C2" modified="2013-07-24" version="1">MSEPDPRERGVPWNTRTVRAVLASTALAPLGVPLIAPGIAPIRDEFAISNARASLLISAYFVVGIVLSPFIGLLIDRIGRRRMLAAGLTTFGAFGTAMAFAPSFDVVLALRVLQGTGAATIFISTVTIITDTFEDAQRNTVLGVNVAVLSAAAAIFPVIGGLLVELAWNAPFLAYAAAFPVAAFVLIGVDEPVRSAPDRGLEYVRSAIDVVVEPVVLSLFGATILTEFLAFGVVFTTVPIVLARSISPVWIGVTLFGAETVATLVAAGSGRLARGLANLHIIALGFACYALGFFGIWAAPAPLFVAMALLVVGAGLGLLLPTVDAAIGARIDSAHRAGAFSVRNSATFFGRAAGPITFVGLAETDLVGFDPLLLAAGIVALAAAVLAWRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7V4</accession>
    <name>R4W7V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_00745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00745"/>
    <dbReference type="EnsemblBacteria" id="AGN00104">
        <property type="protein sequence ID" value="AGN00104"/>
        <property type="gene ID" value="L593_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00745"/>
    <dbReference type="eggNOG" id="arCOG02327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="369"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="596" mass="64437" checksum="597694E8BBF7BA70" modified="2013-07-24" version="1">MAQSFVFVEDPSAATLSYAFATFGVGVLTGFVARYAWRRRDVRGASSLTALMAGVSVWTLCTSLELLSANRDLTLALESVTLGATGVVVIGFVGVAVEISGNDELLDKRIVGLLSIEPVAITLLTATTDLHGLVYQTIEPASKSLDTIDVTTGIAFWLHVGFAYALLATALALVSIQIIRSTGVYRRQAATVLLGALIAIAGNVVRLWGNASIDAEPIGFAVLGGLVAWSIWRYQLIDLVPIAREQVVDTLPDPVVVLDEQDRITDLNEAGITLLGESEDELLGADFDAAFRAFPNVVDTFEDAMQTRQVVRIHVRDEIKDYEVRVAPIEDERGTTRGRILLFHDVSEREVNRRELEHQNEQLERFASVVSHDLRNPLSVAEGYLDLARESGEGEHFETVAEAHDRMHAIIQDVLTMAREGTSVEETSPVSLRAAAETAWSQVDTGDAELVVTEDRTIPADEDRLQRLLENLYRNSVEHGAVPDRSGGDTLTVRIGPIGDDVRTPADEERGFFVEDDGVGIPEADRSKIFEPGHSTGSQGTGLGLSIVRSIAEGHGWSVRATKAPDGGARFEITDVPPIGPAMADPQSSAPDGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W1</accession>
    <name>R4W7W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446142.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06505"/>
    <dbReference type="EnsemblBacteria" id="AGN01248">
        <property type="protein sequence ID" value="AGN01248"/>
        <property type="gene ID" value="L593_06505"/>
    </dbReference>
    <dbReference type="GeneID" id="16181762"/>
    <dbReference type="KEGG" id="sali:L593_06505"/>
    <dbReference type="eggNOG" id="arCOG08089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064673_0_0_2"/>
    <dbReference type="OrthoDB" id="43884at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027839">
        <property type="entry name" value="DUF4432"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14486">
        <property type="entry name" value="DUF4432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="340" mass="37938" checksum="889B82A8DC129545" modified="2013-07-24" version="1">MAAGTHLRVDDAYAYRGIDAVLLENRHLQLLVLSGKGGDVLEFRDKRTDVDVLWHADHDWQAPGDGRLPITEPDAYHDHYPGGWQLHLPMAGETDDFDGTPYGLHGESALLAWDATSERREEAVTLHLETDLLRYPFAIERDLTLRRDEPTLFVEETVTNEGGVAVPFVWQQHLALGPPLVGPDARLELPAETGHVEDYGDGHENARLAGGERFAWPDAPGADGETVDLREFPPYDATIHDLAYATDLREGRYAVSNEEIDLRFEFSFPLDPFEHVWYWQPFGGHAAYPYWNRNYNVGLEPTSAYPAGDVPDAQRANGTLDHLAPGEERSASYEATVGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W7</accession>
    <name>R4W7W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445023.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00870"/>
    <dbReference type="EnsemblBacteria" id="AGN00129">
        <property type="protein sequence ID" value="AGN00129"/>
        <property type="gene ID" value="L593_00870"/>
    </dbReference>
    <dbReference type="GeneID" id="16182251"/>
    <dbReference type="KEGG" id="sali:L593_00870"/>
    <dbReference type="eggNOG" id="arCOG06272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168715_0_0_2"/>
    <dbReference type="OrthoDB" id="119265at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10687" checksum="8FB40D9169EDFC51" modified="2013-07-24" version="1">MFGDGDDGRVTCIACGTELPRSAAREYDKAGDRWEREEKTFEYFCKPCDRDRCHQPRRGLEDALVASGAGECDRSEFLARLSEQWEQPPREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X7</accession>
    <name>R4W7X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_06730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446187.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06730"/>
    <dbReference type="EnsemblBacteria" id="AGN01293">
        <property type="protein sequence ID" value="AGN01293"/>
        <property type="gene ID" value="L593_06730"/>
    </dbReference>
    <dbReference type="GeneID" id="16181850"/>
    <dbReference type="KEGG" id="sali:L593_06730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1375"/>
    <dbReference type="eggNOG" id="arCOG01282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_2"/>
    <dbReference type="OrthoDB" id="22486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="257"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="40073" checksum="881DF97592F7036A" modified="2013-07-24" version="1">MAAQTPVIARAYRTAQGKEDGVYADVRSEDLSVPLIDEILAETGLDPDLIDDLMWGCAQQRGEQGNNLARVIALLSELGESVPATTINRWCASSMQAVISAADAIAAGNRDAIIAGGVESMSRVPMGENTHNVHPRLAELYNIGELQMGMTAEEVAERYEVSREAQDEYALQSHQRAAAATEEGRFDDEIVPIETEDGTVDEDEGIRPDTDLETMAGLPTVFKSDGTVTPGNASQVSDGASALLVTSEAFAEEHDLEIMAEVGTNNVAGVDPRVMGIGPVPATEGLLERNGRSIEDYDLVELNEAFASQTLYAREQLGVDPEIFNVNGGAIAIGHPLGASGARLPVTLIHELQKRGGGRGLATLCVGFGQGAAIEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z2</accession>
    <name>R4W7Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446232.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01338">
        <property type="protein sequence ID" value="AGN01338"/>
        <property type="gene ID" value="L593_06955"/>
    </dbReference>
    <dbReference type="GeneID" id="16181941"/>
    <dbReference type="KEGG" id="sali:L593_06955"/>
    <dbReference type="HOGENOM" id="CLU_2067907_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12145" checksum="068DC0D6EA77481E" modified="2013-07-24" version="1">MGPTPDATVVLQRVGAGLIAGAFTLVLLAALLLAEIAALVVIGAGLAVYAFEHQRGLPRGLATGLVIAAILPILDRQFDPVGATLLRSTVVTVVIGIGLLFGAFVIDRYGQQLFDGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W802</accession>
    <name>R4W802_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446272.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07155"/>
    <dbReference type="EnsemblBacteria" id="AGN01378">
        <property type="protein sequence ID" value="AGN01378"/>
        <property type="gene ID" value="L593_07155"/>
    </dbReference>
    <dbReference type="GeneID" id="16182019"/>
    <dbReference type="KEGG" id="sali:L593_07155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1461"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124463_0_0_2"/>
    <dbReference type="OrthoDB" id="94536at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15552" checksum="A6C8C7A4F079F93F" modified="2013-07-24" version="1">MSITDHVEDIVHEETQVHRGEAAIDLTATEIYEIAEPGRVDFGGGELEPADLQPHDRVWRNEADDYQWWHLDAGQYLLEFNETVVADDRLVLQPRDAILERGASHPTLHVESVERIPLAVGGAGLRLKENARVSTLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W855</accession>
    <name>R4W855_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446397.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01503">
        <property type="protein sequence ID" value="AGN01503"/>
        <property type="gene ID" value="L593_07790"/>
    </dbReference>
    <dbReference type="GeneID" id="16182220"/>
    <dbReference type="KEGG" id="sali:L593_07790"/>
    <dbReference type="HOGENOM" id="CLU_194987_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="5965" checksum="692A2D2BFA8DE24A" modified="2013-07-24" version="1">MLKHLGIGGILGVFLLVGGVALIGWVNPVIAAGIAISIAGLGLIVRSLVSSALGAMGMGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C6</accession>
    <name>R4W8C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase 49 kD subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02890"/>
    <dbReference type="EnsemblBacteria" id="AGN00529">
        <property type="protein sequence ID" value="AGN00529"/>
        <property type="gene ID" value="L593_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.584"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="6">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="333"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="583" mass="65317" checksum="DA4A916A41A6D0DA" modified="2013-07-24" version="1">MSRQPEQQRLERPEPEACDAAGPLVDLPSAVPASIADAVLDTDDHLNAPAIVIRPDDVERVLAALKREAGYDHCACVTAQQYADRYESIYHLRTYADPTDELGVVVPTTPEDPTSESAAAVYDTARWHEREAYDLVGIEYDGHPNLERILLPDTWQGHPLRDDYDQDRPQIVTLSEHANPLAVDERVAGQPATEATDERTTGAAHAADTDTMFLNIGPHHPATHGVLHLKAVLDGEQVLDVEPDIGYIHRCEEQMCQQGTYRHQIMPYPDRWDWSGAGLCNEWAYARAAEDLAEIEVPEYAQVIRTMSAELSRMLGHLLAAGTYALDIVGDFTALFMWSMREREKVQAVLEELTGQRLMFNYYRLGGVAWDLPEPREEFFDLTRDVVEGIPKAMDEYHALLTNNEVMQLRTIDTGVLEPEVAKSYGCTGPVARGSGIDYDVRRDDPYGYYDELDWEVCVEDGCDNYARVLVRLRELEQSARIVEQCIDLLEAWPDDEREIQSNVPRTLKPERDAEIYRAVEGAKGELGIYIRADGTDTPARFKIRGPSFSNLQALPEMAEGGYVADLVATLGSLDPIMGDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D0</accession>
    <name>R4W8D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445433.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02940"/>
    <dbReference type="EnsemblBacteria" id="AGN00539">
        <property type="protein sequence ID" value="AGN00539"/>
        <property type="gene ID" value="L593_02940"/>
    </dbReference>
    <dbReference type="GeneID" id="16180414"/>
    <dbReference type="KEGG" id="sali:L593_02940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.595"/>
    <dbReference type="eggNOG" id="arCOG02192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154327_0_0_2"/>
    <dbReference type="OrthoDB" id="100806at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018664">
        <property type="entry name" value="DUF2103_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09876">
        <property type="entry name" value="DUF2103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="238" mass="25543" checksum="A10AD7A872DDE91B" modified="2013-07-24" version="1">MDCRRCAEPLDRPGDYCLVCNTANADAVVIDADRERATLTMLDEDAVVGSSVVRTTEEDGENAIKELRAFAGQIADELHRKRPETVYAAGDRQVLREIQGESQYELLRVTGDDPVETAIDRRGERSLDVVDAAPAEKIGGSHSTLIGGREGMRAIRTVAGHPHVKKVIPGPIDAGGTGSQSGLRAKATRADAGGNVRLLLRDGSSVQENRVVTTAREADAGELIREDLNAALDEADLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H7</accession>
    <name>R4W8H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type transport system periplasmic substrate-binding protein (Probable substrate iron)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446682.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09215"/>
    <dbReference type="EnsemblBacteria" id="AGN01788">
        <property type="protein sequence ID" value="AGN01788"/>
        <property type="gene ID" value="L593_09215"/>
    </dbReference>
    <dbReference type="GeneID" id="16180834"/>
    <dbReference type="KEGG" id="sali:L593_09215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1892"/>
    <dbReference type="eggNOG" id="arCOG00227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_2_0_2"/>
    <dbReference type="OrthoDB" id="26447at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="385" mass="40902" checksum="6BB6CEA268001C43" modified="2013-07-24" version="1">MTDTPRDSPIGRAPDDRDGRSSRRAFLASAGALGAVGLAGCIDFPGGGNDDSEPFNWIGSGPGARLGQDGTPMSAMPDLEGELTVYSGRHQFLVGDLIDSINSLYDDFHAEVRYGGSSSEMVNQIITEGSGTPADVFYSVNAGSLGSLAESGRTQALSSDLLELVRPEFHTDQWIGTSGRARSVPYNTNAFSASELPDDIMAYPDLDADFGWAPTYGSCQAFVTAMRILEGDEATRQWIEGMLDQGIQTYPDEFVANQAIADGEIDVGFTNHYYIQRVLDGNPDAPIATAFTQGDAGATFNVAGAAVVDQANDPTLAENFVRHLLSAEAQAYFAVETFEYPLAPGVDPVGDLPRIDELDVPDVDLAQLGDMSGTVDLMESAGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8H8</accession>
    <name>R4W8H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446687.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09240"/>
    <dbReference type="EnsemblBacteria" id="AGN01793">
        <property type="protein sequence ID" value="AGN01793"/>
        <property type="gene ID" value="L593_09240"/>
    </dbReference>
    <dbReference type="GeneID" id="16180500"/>
    <dbReference type="KEGG" id="sali:L593_09240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1897"/>
    <dbReference type="eggNOG" id="arCOG04794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056498_0_0_2"/>
    <dbReference type="OrthoDB" id="14967at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="388" mass="41415" checksum="506E6F13B4AE2B32" modified="2013-07-24" version="1">MEYVQERVATLHDFAGHVPDAPLSSTAVVVPVMPREVGRPAAEHTFETLAGHDLECVVVPVRAPAERIDEIRDWLAGFDLQMELLWCNGPAVEELLADAGLAYTGDSAGPDSAPAVGKGADVWLGLGVAADRGEYVVVHDADATSYDAAHVPKLAAPLANAECSFTKGYYARVEEDGLYGRLCRLFYEPLVAALEDLHDEPTGDANGGIVDYLAAFRYALAGEFGATADVVQSMRAQRAWGLEIGTLGEAFRLAGPEGSAQVDLGIHRHDHRSVDGEGGLASMSEQVGAALFRALADRGIEVEYDQLCEAYLAHGDRLVAQYAADAAHNGLPYDREAERDQVRAYVDAIAPPGPDARLPAWTDASIEPADVLDASTRALRSADVLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q2</accession>
    <name>R4W8Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445718.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04365"/>
    <dbReference type="EnsemblBacteria" id="AGN00824">
        <property type="protein sequence ID" value="AGN00824"/>
        <property type="gene ID" value="L593_04365"/>
    </dbReference>
    <dbReference type="GeneID" id="16180917"/>
    <dbReference type="KEGG" id="sali:L593_04365"/>
    <dbReference type="eggNOG" id="arCOG04574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_3_1_2"/>
    <dbReference type="OrthoDB" id="78720at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="192" mass="21978" checksum="B89D4333921A2D29" modified="2013-07-24" version="1">MVIWIVAGFVALVLLVLLVAYTVSIYNQLVSLRERVDQAKQNIDVLLKQRQDELTKLIDAAQEFMDHEEQVLTQLTEAREAAERASSPAEEAAADQQIRQALMDFEARAEAYPDLRSQTNMLQFQERISEIESQIADRREFYNEAVTQNNTRIAQFPYVLIARQFGFQERELFEATEAEKADVDVGAAFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q9</accession>
    <name>R4W8Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein cina-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445738.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04465"/>
    <dbReference type="EnsemblBacteria" id="AGN00844">
        <property type="protein sequence ID" value="AGN00844"/>
        <property type="gene ID" value="L593_04465"/>
    </dbReference>
    <dbReference type="GeneID" id="16180953"/>
    <dbReference type="KEGG" id="sali:L593_04465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.910"/>
    <dbReference type="eggNOG" id="arCOG04589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_1_2"/>
    <dbReference type="OrthoDB" id="115307at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="17970" checksum="314B571B3311050E" modified="2013-07-24" version="1">MGTDESIAKRIGEALRDREETIAVAESCTGGLVGSMLTDVPGSSDYFVGGIISYMNQTKLQQLAVSREALENHGVVSEPVAREMAQHVRDEADATWGVSTTGYAGSPVHSADHPAGTVFIGVAYAGSPDASDPYAVVEHHQFDGDRHEVKERIATQALRSTLAQIRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S3</accession>
    <name>R4W8S3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04650"/>
    <dbReference type="EnsemblBacteria" id="AGN00879">
        <property type="protein sequence ID" value="AGN00879"/>
        <property type="gene ID" value="L593_04650"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.950"/>
    <dbReference type="eggNOG" id="arCOG03050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_19_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="18489" checksum="C9F2C7FDF730B91B" modified="2013-07-24" version="1">MPPTDPHERRQRADRWLADGAGGLAIVVAVGGRDVQRVDGLADAVADLAGPALANVHVVHAYTPEQFDETTDRLNFPDDAPPEPDEVARRTKAVRDLVDRLETATAEDATRIEVHGTVNEDAGEAIVDLATDVEADRVLVGGRKRSPAGKAVFGSTAQHVLLNADCPVTFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W935</accession>
    <name>R4W935_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Terminase_6C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01159">
        <property type="protein sequence ID" value="AGN01159"/>
        <property type="gene ID" value="L593_06050"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06050"/>
    <dbReference type="eggNOG" id="arCOG09550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614846_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="1">
        <location>
            <begin position="259"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="421" mass="47154" checksum="142F690E3B509082" modified="2013-07-24" version="1">MSETGEDDTAVQRRILRSLWEPHPGQRAIMAHPARFRVVACGRRWGKSEMCAHLALEHALEHPGSTVWWVAPTYDQANEFGFDKVKPLLSTTVLADDPKRTKPREFVLTNGSTVSFRSAEREDSLRGGGVDFLVIDESGSVPDRAWTDELRPALSDTEGDAVFVGTPKGRNWFHQWFQRGQSADHPEVASWQAPTIQNPHVPDEEVEAAREDMPERVFEQEYRAQFVDDTGGVFRNVREQVEDYDLPVAPADCEAPFAIGVDLARLQNWTVAVVLDDRGTVVAFERLQQTTWSRIQQTIEQLAGRYDPATVALDASRDNKIVQDLADAGLATEPVRFTPAKKRTLVENLATALEIDELTLSSDATPLVNELEVYEYEATESGQIRYTAPSGFHDDCVDALALAEWARSNARREPIQVPSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W973</accession>
    <name>R4W973_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447342.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12545"/>
    <dbReference type="EnsemblBacteria" id="AGN02448">
        <property type="protein sequence ID" value="AGN02448"/>
        <property type="gene ID" value="L593_12545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180021"/>
    <dbReference type="KEGG" id="sali:L593_12545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2575"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_3_2"/>
    <dbReference type="OrthoDB" id="14436at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="153"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="399" mass="42784" checksum="D0F5109A59EF7F97" modified="2013-07-24" version="1">MRNSAPLDAALAEHDADGYLIDADATEADQYYLAGFGAPDPFLTCYTPDGVHLLVSELEYGRAKSESSADTVARNADYDHREHVAEHGALEGRNRTIAAFVADHGVEHVLVPDRFPTATADGLRAQGIEVTADLEETVATIRARKTDEEVGHLKAAQRANEAAMDRAAELIGGAEIVTGADAADDQDATLHHGGDPLTSEFVKTEIEIALLREGCALDETIVAGGADGADPHNRGSGPLPAHEPIVVDIFPRDKETKYHADMTRTFVRGQPSEEVVRRHEVTIAAQEAAFDAIEPGATGEAVHDAVCDLYEAEGYETLRSDDTTETGFIHGTGHGLGLEVHELPRLAPDGKELEPGHVVTVEPGLYDPAVGGMRIEDVVVVTEDGFENYVDYPKDLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R4W982</accession>
    <name>R4W982_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06535"/>
    <dbReference type="EnsemblBacteria" id="AGN01254">
        <property type="protein sequence ID" value="AGN01254"/>
        <property type="gene ID" value="L593_06535"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06535"/>
    <dbReference type="HOGENOM" id="CLU_2784275_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="68" mass="7497" checksum="BB46F9BC324800ED" modified="2013-07-24" version="1">MPDRLDARPTVTVSEVLRNAIVVGANRRLTILPIREILLFSDTIDRQADADRPDFAAAIGDESEVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A1</accession>
    <name>R4W9A1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_06810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06810"/>
    <dbReference type="EnsemblBacteria" id="AGN01309">
        <property type="protein sequence ID" value="AGN01309"/>
        <property type="gene ID" value="L593_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06810"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1391"/>
    <dbReference type="eggNOG" id="arCOG00925">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="311" mass="32888" checksum="CCF89B8344AF21AA" modified="2013-07-24" version="1">MSDAPAGSDAGADPGETGNGGTGGGRTGGASTPDPAPASVRTVPEPEPPGWGDGEGDAILQIDGLRKTFGGITAVDDASFAVERGTITGLIGPNGAGKSTTFDLVTGFTRPNGGEVTFDGRSITGLAPHQIAQAGLVRTFQITREFPDMTVLENLMVAPKGQRGESLSRSVLPGARGAVVAQERELVGEIWEVLDTFEIDHLADEYARSLSGGQRKLLELARALLTEPELLLLDEPMAGVNPSLEEKLLERIHDLRAEGYSFLLVEHDMDLIMEHCDRVIVMHQGQVLAEGEPETIRENEAVIEAYLGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C5</accession>
    <name>R4W9C5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446273.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01379">
        <property type="protein sequence ID" value="AGN01379"/>
        <property type="gene ID" value="L593_07160"/>
    </dbReference>
    <dbReference type="GeneID" id="16182024"/>
    <dbReference type="KEGG" id="sali:L593_07160"/>
    <dbReference type="eggNOG" id="arCOG04789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160437_0_0_2"/>
    <dbReference type="OrthoDB" id="123098at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="10277" checksum="B5C6FBEF1BF5984D" modified="2013-07-24" version="1">MEEKVFVSSGRMAREEIAEYLRAVAESLDRGASITLTEGDESVTLEVPAEPTFEVQVEHEGPEGAMTERSIEFELEWDEAEEGEAAAGGDLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H1</accession>
    <name>R4W9H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446403.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07820"/>
    <dbReference type="EnsemblBacteria" id="AGN01509">
        <property type="protein sequence ID" value="AGN01509"/>
        <property type="gene ID" value="L593_07820"/>
    </dbReference>
    <dbReference type="GeneID" id="16182289"/>
    <dbReference type="KEGG" id="sali:L593_07820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1602"/>
    <dbReference type="eggNOG" id="arCOG01320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_2_2"/>
    <dbReference type="OrthoDB" id="72536at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="26932" checksum="BA4C98BD53249430" modified="2013-07-24" version="1">MGGSDVRGEEEPAETGGDHRASGATDSVDRAIEAFRAGEPICVHDADDREGETDILYPATAVDPDALAQLRNDAGGLVCVALAADVADAADLPYYVDAVEHPATMTGATAYGDRPSFSLTVNHSGTYTGITDEDRALTISELGGFAADVADGALGGGDGTLADPTDAFAEEFRVPGHVHLLRAAPELLDERRGHTEFAVALAEEAGIPPAVVVCEMLDDASGEELSVAGAREYADRHDIPFLEGEDVVGALQRDTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K2</accession>
    <name>R4W9K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446488.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08245"/>
    <dbReference type="EnsemblBacteria" id="AGN01594">
        <property type="protein sequence ID" value="AGN01594"/>
        <property type="gene ID" value="L593_08245"/>
    </dbReference>
    <dbReference type="GeneID" id="16182346"/>
    <dbReference type="KEGG" id="sali:L593_08245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1690"/>
    <dbReference type="eggNOG" id="arCOG03042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942013_0_0_2"/>
    <dbReference type="OrthoDB" id="73967at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="27008" checksum="D75F4323FAD953B8" modified="2013-07-24" version="1">MTDREDHDYSEGQGLPESPEGFDLDPPELAVDPDQVDPVDSRVVADTLDERQIASENVDAESLLEVGLEYVRINRFEEATETFERAARYAEGESVEQEAWTNKGVAHAELEEYDAAIGAYREALSLDGTSDHEASAETNLAYALWESGQTAQALEHAERAVEADERFARGWYNRGFFLLERGLAEDAIDAFDNAQRLGMRSPELLEEKARALEEAGEYDRAEELADEAQELREQAEAEMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L3</accession>
    <name>R4W9L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sporulation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447652.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14095"/>
    <dbReference type="EnsemblBacteria" id="AGN02758">
        <property type="protein sequence ID" value="AGN02758"/>
        <property type="gene ID" value="L593_14095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182025"/>
    <dbReference type="KEGG" id="sali:L593_14095"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105299_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="172" mass="18820" checksum="DC5844BA8B4DD94C" modified="2013-07-24" version="1">MTGPDDRSDAGATTTEPADRIAEATIDDLDAIVDRWVALIDHGDQYGLHIRGEANRTIARESLAAAIADDLAFVATIEDRVVGFCSLTLETGGFERDVVRGVVENLYVDPAARGVGLGSALLEAGERRLVERGADVIAVETMAVHESIRAFYEERGYRPHRLTLERRVETNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P3</accession>
    <name>R4W9P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14385" checksum="012B267D05245CD8" modified="2013-07-24" version="1">MATQPCDGCGRPVSVAGGIANLWSFERSTTDGLQLELADGTDHFLCFECVDDLPDDAAEADVDALPDRPPDEPIGRPEWAEDADGGLQFAFVGTGLGALAGAGIGILTGSLEYWFVTGAAIGLLLALLVERFLSRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U9</accession>
    <name>R4W9U9_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:organic substance biosynthetic process"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
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        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="2">
        <location>
            <begin position="40"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="360" mass="39108" checksum="B6925829D7656179" modified="2013-07-24" version="1">MATDQSPIETEATGTAATDGVDRSDWTVSPDPESVETEDLTLVQGVQAGLATEMQRDDSVLVMGEDVGENGGVFRATQGLYDEFGEDRVIDTPLAESGIVGTAVGMAAYGLRPVAEMQFMGFIYPAYDQIVSHAARLRTRSRGRFTAPLVIRAPYGGGIRAPEHHSESTEAMFAHQPGLKVVMPSTPYDTKGLLASAIRDPDPVLFLEPKLIYRAFREPVPTQEYTVPIGEAAVRREGSDVSVFTWGAMARRTLEAAADLEGEIDVEVVDLRTISPLDEETIVESFKKTGRAAVVHEAPKTGGMAGEIAATIQEEALLYQEAPIERITGFDTPFPLYALEDYYLPEAARIADGIREAFEF</sequence>
</entry>
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    <accession>R4W9X0</accession>
    <name>R4W9X0_9EURY</name>
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            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01939.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01939">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG03051">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
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    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
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    <dbReference type="Pfam" id="PF00582">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="13326" checksum="3215785B8741B6D5" modified="2013-07-24" version="1">MRSLLAVDTVHTAAAAADYLDDRLDRGDDVVALAVVGPDDAGADATRDGKEALNVLGVRLATVDVETVERRGEPSEVILDLAETRDVDQIVLGARAGTPDAATDGVGSTTVEVLEDATVPVVVLPIGEH</sequence>
</entry>
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    <accession>R4WA03</accession>
    <name>R4WA03_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="L593_10795"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_10795"/>
    <dbReference type="eggNOG" id="arCOG04946">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
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        <property type="entry name" value="VOC"/>
    </dbReference>
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        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13908" checksum="BDADD8B9D959B667" modified="2013-07-24" version="1">MHRVVHFDIMADDPHRAIEFYTDVFGWSIEKWNGDEMEYWLVRTGDGDGPGIDGGLARRGDDAPVDGQANAFVCAIEVDDVEAVVDDVEAAGGVVTTEVMDLERAGRIAYCLDTEGNQFSLWEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA14</accession>
    <name>R4WA14_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02159.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11070"/>
    <dbReference type="EnsemblBacteria" id="AGN02159">
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        <property type="gene ID" value="L593_11070"/>
    </dbReference>
    <dbReference type="GeneID" id="16180556"/>
    <dbReference type="KEGG" id="sali:L593_11070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2284"/>
    <dbReference type="eggNOG" id="arCOG06248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2243758_0_0_2"/>
    <dbReference type="OrthoDB" id="117321at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="12655" checksum="D035F15B4DF202FE" modified="2013-07-24" version="1">MTLEDLEADVQATYDALNEDLELALDEETRRELTMLQTVLDAEDADEIVKRAVHLFFQSTVETGRLDFHLRSTYDVTYDEYLSGMTYDEMTGAGQFPQPAENDDRRYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA45</accession>
    <name>R4WA45_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11855"/>
    <dbReference type="EnsemblBacteria" id="AGN02314">
        <property type="protein sequence ID" value="AGN02314"/>
        <property type="gene ID" value="L593_11855"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11855"/>
    <dbReference type="eggNOG" id="arCOG01661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_0_0_2"/>
    <dbReference type="OrthoDB" id="19494at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="183"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="461" mass="48271" checksum="2B9069335DE460EB" modified="2013-07-24" version="1">MQALGAASAAAIAGCSSDGGGGSGDDGNDSTGGSTDAPAADDGDATGDGSAQDEPQSPEAAARQLVDHLFAGEYEAGQALFVEAYQSRATPAILERLRLGFNAAGGAFQEITGVETSVRSGLDAVDLTLQLERTTAPFRVTVTQDVQIRSAIIAGEYERASYADAGRFDATEHTLEPGGCQLGATVTTPADAEQAPGVVLVHGSGPSDRDLTVGANKPYRDLAEGLASRGVAVLRYEKRTFACNVAAAEHTVDHVTVDDALHALSWFRNRDDVLADDVAVVGHSLGAMMAPEIARRDGRVAGAVGLAAPTRPLADVFLDQVDHLASVGEHTPSGIEQQRNQWQRAAEQIRTGNFEDDESLLGYPGALWRSLDGYDPVATAEGLDVPQHYLQGGRDYQVTVEDDFAAWQSAFGDADDVALSAYDPLNHAFLPGQGPSVPQAYAVPNQVSESVVADLAAWLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA81</accession>
    <name>R4WA81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02494">
        <property type="protein sequence ID" value="AGN02494"/>
        <property type="gene ID" value="L593_12775"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2621"/>
    <dbReference type="eggNOG" id="arCOG07584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211277_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="50" mass="5655" checksum="3EFF012948C680CC" modified="2013-07-24" version="1">MGTSTEPTAEEVTRPDGRPCPSCGETMYHRHCKYVCPRHGVVYDCADTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD7</accession>
    <name>R4WAD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447668.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14175"/>
    <dbReference type="EnsemblBacteria" id="AGN02774">
        <property type="protein sequence ID" value="AGN02774"/>
        <property type="gene ID" value="L593_14175"/>
    </dbReference>
    <dbReference type="GeneID" id="16181079"/>
    <dbReference type="KEGG" id="sali:L593_14175"/>
    <dbReference type="eggNOG" id="arCOG02608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_8_2_2"/>
    <dbReference type="OrthoDB" id="124641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="84" mass="9309" checksum="140409357B2A787A" modified="2013-07-24" version="1">MSLTLYQLDGCPFCEKVADALDDNGIEYDTIWVDAPHSERNEVKRVSGQRGVPVIVDEDRGVTMAESDNILEYIEHTLAPQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE1</accession>
    <name>R4WAE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447688.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14275"/>
    <dbReference type="EnsemblBacteria" id="AGN02794">
        <property type="protein sequence ID" value="AGN02794"/>
        <property type="gene ID" value="L593_14275"/>
    </dbReference>
    <dbReference type="GeneID" id="16180973"/>
    <dbReference type="KEGG" id="sali:L593_14275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2922"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788988_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="37715" checksum="246E79EDF21F1399" modified="2013-07-24" version="1">MTDQHDVDGTRSESGESDASDHAAGEGSRNRDRPEDDPVSHSRGLLARLGGAAGIASVAGCVGGDGDDGGDGDGQDDGGGDADGTDGDGSGGDDGDDTGSSDGDDRDPIDPEQRAIELRAILKEFEGAYDQSVLDRAEAVRQQHTDSVVFVDLRPEPVPHRLATGWFVAENRVVTVKQKLASQRGPLERVTVHTADGEAHEAAVVERHQGVEDLALLELDVPGSPIDRSVVAESPPEPNEPLVQIGHHDEYGHWVATVGDYLRTQTFDANPDYIDEHWSNVHGLPGTGGAPVFDLDGRFVGMTNGAVARESRGEAPPEPLNDYVYDWQMSHREWFNHLDAQQTLEEIDPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF0</accession>
    <name>R4WAF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaemetzincin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447733.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14500"/>
    <dbReference type="EnsemblBacteria" id="AGN02839">
        <property type="protein sequence ID" value="AGN02839"/>
        <property type="gene ID" value="L593_14500"/>
    </dbReference>
    <dbReference type="GeneID" id="16181283"/>
    <dbReference type="KEGG" id="sali:L593_14500"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493034_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="20049" checksum="2C9F41B17B4C03C0" modified="2013-07-24" version="1">MAPPERDGDPEVLPVGDVEPFAVVEVQQAIERTFDLTMTQRQPLELPVADAGGIREQYDVESLLDEIDDVATAGPTVAVTDADLLADGREHILGVNRLPGSTLVLSTNRLETRDRQRFRERLRKEALHLVATMYLVDHCVGDPTDWSDCVHQYTPSVSELDETSESFCPACREALDEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS54</accession>
    <name>R4VS54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444944.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00475"/>
    <dbReference type="EnsemblBacteria" id="AGN00050">
        <property type="protein sequence ID" value="AGN00050"/>
        <property type="gene ID" value="L593_00475"/>
    </dbReference>
    <dbReference type="GeneID" id="16181630"/>
    <dbReference type="KEGG" id="sali:L593_00475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.97"/>
    <dbReference type="eggNOG" id="arCOG00061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_2"/>
    <dbReference type="OrthoDB" id="40508at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="427" mass="46132" checksum="C575B2255C56F3D8" modified="2013-07-24" version="1">MTEDQHGFYTRSLHAGQEADPTTGARAPPIYQTTSYEFEDAEHAASLFALEEPGNIYSRIMNPTNAVLEERLASLEGGVGALATSSGMAALDLATFTLASEGDNVVTASALYGGTYIYFTHTAPRRGIETRFVDTLDYDAYAAEIDEDTAYVHLETIGNPALVTPDIERIADIAHEHGAPLFVDNTFATPYLCNPLDHGADLVWHSTTKWIHGAGSTIGGILIDGGSFDWNGEDYPEIAAENPAYHGVNFQERFGDAAFLATARARALRDLGNQQSPFDAWVTTQKLETLPLRMERHSENAMAVAEHLDEHPEVDWVTYPGLEDHETHDLSTQYLDGGYGGMIAFGLAGGYDAARTTVESTELASLLANVGDAKTLIIHPASTTHQQLTEEEQLASGVTPDLVRLSVGLEDVEDVIADLDDAIDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS82</accession>
    <name>R4VS82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00080">
        <property type="protein sequence ID" value="AGN00080"/>
        <property type="gene ID" value="L593_00625"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.127"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091367_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12325" checksum="1AE7C2FDED776241" modified="2013-07-24" version="1">MALEDSIVVFVVSLLIGAFGIYVGAGAVTDYSSYTYAIVTALLGAIIWGVVGFLLGWIPLLGPLLVLLAYIWVIKARYPGGWGDAILIALIAWIAVVLVLYAVALLGIASYGAVGVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUP2</accession>
    <name>R4VUP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coenzyme F420:L-glutamate ligase</fullName>
            <ecNumber evidence="8">6.3.2.31</ecNumber>
            <ecNumber evidence="8">6.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coenzyme F420-0:L-glutamate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofE</name>
        <name evidence="10" type="ORF">L593_00130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="8">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CofE family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="8"/>
    <dbReference type="EC" id="6.3.2.34" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444875.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00130"/>
    <dbReference type="EnsemblBacteria" id="AGM99980">
        <property type="protein sequence ID" value="AGM99980"/>
        <property type="gene ID" value="L593_00130"/>
    </dbReference>
    <dbReference type="GeneID" id="16181021"/>
    <dbReference type="KEGG" id="sali:L593_00130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.26"/>
    <dbReference type="eggNOG" id="arCOG02714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051152_1_1_2"/>
    <dbReference type="OrthoDB" id="73785at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01258">
        <property type="entry name" value="F420_ligase_CofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023659">
        <property type="entry name" value="F420_ligase_CofE_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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        <location>
            <begin position="38"/>
            <end position="39"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGM99980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="28289" checksum="785E3603D327734B" modified="2013-07-24" version="1">MHCLAVEGLPEVRPGDDLASLIEERCTLHDDDVVCVASTVVSKAEGRAFDLSAFPASERARSIAARLEAISGDEKDPRFAQAVLEESETLVMEAPFLLAATRFGHVAPNAGVDRSNVPDSDLLLLPDDPMASAERIRSNLDADASVVVTDTCGRPFRHGQTGVAIGYAGIPATRDWRGETDRDGHELEVTNESIVDELAATANLLTGEGDDGVPVVVIREFEFGDHEGSEHLFRDASEDLVREALQEWTFSDASDAGSATEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUV6</accession>
    <name>R4VUV6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 7">Histidinol dehydrogenase</fullName>
            <shortName evidence="6 7">HDH</shortName>
            <ecNumber evidence="6 7">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">hisD</name>
        <name evidence="13" type="ORF">L593_05330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 12">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6 7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445909.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05330"/>
    <dbReference type="EnsemblBacteria" id="AGN01015">
        <property type="protein sequence ID" value="AGN01015"/>
        <property type="gene ID" value="L593_05330"/>
    </dbReference>
    <dbReference type="GeneID" id="16181324"/>
    <dbReference type="KEGG" id="sali:L593_05330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1089"/>
    <dbReference type="eggNOG" id="arCOG04352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_2"/>
    <dbReference type="OrthoDB" id="55330at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6 8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="423" mass="44745" checksum="16B55EB8721B8B7C" modified="2013-07-24" version="1">MNVRAIADLPPDERAALFERDAGIGDARADAREIVERVRDEGDVALREYAEDLDGVAVGNLDVTDEAERAWERLDGDLRTAIEDAIENVRAFHERQVPEDWTEEFEGRELGRRFRPIERAGVYVPGGTAAYPSSAIMGVIPAAVAGVEQIAVATPPAEEFSDATLGAIHAARADRVYAAGGAQAIGALAYGTETVDRVQKIVGPGNRWVSAAKAEVRGDVEIDFVAGPSEVLVLADETADPTLVAAELVAQAEHSPNAAVVAVTDDEALAEAVAESVESQAAERDRTETIQAALDNDASGILLARSQSEAVAVAEEFAAEHLAIYADEPAELADRVPSAGSVFLGEYTPVAAGDYASGTNHVLPTNGLARVTGGLSVDTFLRASTVQRLDRDALADLRGTIETLAEAEGLDAHAESVRKRFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV55</accession>
    <name>R4VV55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445045.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00980"/>
    <dbReference type="EnsemblBacteria" id="AGN00151">
        <property type="protein sequence ID" value="AGN00151"/>
        <property type="gene ID" value="L593_00980"/>
    </dbReference>
    <dbReference type="GeneID" id="16181814"/>
    <dbReference type="KEGG" id="sali:L593_00980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.201"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="67630at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="28473" checksum="134BDB283CE6700A" modified="2013-07-24" version="1">MSKTQRSDGDAGSGVVTAHNVGRTYYMGEPVHALQNLSLALEEGSFTAVMGPSGSGKSTLMNMLGCLDTPDEGTVEIDGRSVGDLSGAQRAKLRGTKIGFVFQTFNLMPRLSAAENVTLPMVFNDVVDEGRRERAQTLLERVGLGDRLDHAPNELSGGQRQRVAIARALANEPTLILADEPTGNLDSETGADIMDLFEELHDEGRTILMVTHERHIAEHAERIVHLLDGELDYIEEFDSAGVEDGGPKTAQPTADESIGTSGGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVF9</accession>
    <name>R4VVF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S45 penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_01365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445120.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01365"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="AGN00226">
        <property type="protein sequence ID" value="AGN00226"/>
        <property type="gene ID" value="L593_01365"/>
    </dbReference>
    <dbReference type="GeneID" id="16182644"/>
    <dbReference type="KEGG" id="sali:L593_01365"/>
    <dbReference type="eggNOG" id="arCOG04082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_0_1_2"/>
    <dbReference type="OrthoDB" id="3179at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="825" mass="90390" checksum="CD68AD55C2591ABD" modified="2013-07-24" version="1">MVSEHTRRAILGAALGSGIAISGVPQIRRYLRLFAPLSGGAWDAARRDPGGDFASPYGDATIRKDEYGVPHVDAESEEALAYATGYVHGTDRLFQMDLFRRQMRGTLSAVAGDATVESDEFHRRMDFTAAAEATVEQLRGTETEPIVEAYVEGVNEARRTEGLQLEFELLEYEPDPWTATDVMLVEKQISWGLTGNFRPLQQAVVADEFGEDVVERLYPDRMDHDSPILREQTLESGSQELPGSGAAAEASALIGDELKSVSDRADRKPTGPSGTGGHRVGPELADYCSQFTWPTGVGSNSWVVSGEHTADGEPIVCNDPHLLLLAPPVWYEQHLECAAFETRGVAFPGAPFVVIGENDSGAWGFTNVGADVCDHYSYETDGNRYRYGDEWREFETEEVEIEVDGASNETITRRKTVHGPVVEEAGQEVAVQWTGLAGTETFAAVRDLAHSEGLEDAVAALRRFDAPTQNFVYADTAGNTFYWTTGRMPIRRSDGEIVRGDRIFDGSAREGEWTGFEPYGQPSWEGFVPFEDKPGVVNPDYLATANQRVIDEPGFYVADGYAPPFRGARAYERLDAAVAEGPVDLDTMRDVQQDVLDRRARLLVPDLLEVRDRLSGGAASLADDLDGWDERTTTDSRGALAFDHLLDAFREIVFEEPFEARSALDDLDSLPTPNDWILLTLPADDPWFDRDAVPAREDALIEAAERAAAEIDDAGHGTYGDANRLGIEHPLGVGFLAYPSKPAEGSDVTLKNVRVDDDVGSSWRMLAPPNGDSEAILPGGNDGDYFSEHYHDQLSMWLDGEYKTMAREHRGSTFATFSGDGGDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVH1</accession>
    <name>R4VVH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L593_01440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445135.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01440"/>
    <dbReference type="EnsemblBacteria" id="AGN00241">
        <property type="protein sequence ID" value="AGN00241"/>
        <property type="gene ID" value="L593_01440"/>
    </dbReference>
    <dbReference type="GeneID" id="16181883"/>
    <dbReference type="KEGG" id="sali:L593_01440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.293"/>
    <dbReference type="eggNOG" id="arCOG01361">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_2"/>
    <dbReference type="OrthoDB" id="7724at2157"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="445"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN00241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="567" mass="63962" checksum="E6AD78273D02637F" modified="2013-07-24" version="1">MSTGDGFEQACEELVERVLAGELERDDVESAKLEVCSKYSASKVPKHTELLDRAPDGRRDELAEVLHRKPVRTASGVSPVAIMTSPAPCPHGKCLYCPGGPDSEFESSQSYTGLEPAAARGEQNDYDPYGQVTLRLNQLREIGHPVDKVELILMGGTMTARSHDYQEWFVKEALRAMNDFDPDAEPNPAEDESFAPERPAARDRSVARTPGEYHYTEDVIARNETGDVRAIGITFETKPDWCDPEQVNRMLRLGGTKVEVGVQTTFERINREMHRGHGMEAAVSANRRLRDAGFKVGFHMMPGQPGASKEMVLEDFRRLVERPEWRPDYLKIYPTLIVEDTVTYDMFRRGEFEPLGNDEAAELVAEIKSMLPRYTRLQRVQRDIPATIIEGGVWKSNLRQLARQRMDEHGWTCDCIRCREVGMNDEVPESPELRVDTYEVAGGTEHFCSIEDFDRDLLIGFCRLREPGDPIRRELQDAAIIRELHVYGSELGIGEPGGTEDDAAQADEADAGFQHQGHGRRLVERAESIARERGYEKLAVIAGIGAREYYREQLGYRQDGPYVSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVL4</accession>
    <name>R4VVL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446129.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06440"/>
    <dbReference type="EnsemblBacteria" id="AGN01235">
        <property type="protein sequence ID" value="AGN01235"/>
        <property type="gene ID" value="L593_06440"/>
    </dbReference>
    <dbReference type="GeneID" id="16181741"/>
    <dbReference type="KEGG" id="sali:L593_06440"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="28117" checksum="C9BB92A8D38F1318" modified="2013-07-24" version="1">MATKRHAERTAIVTGASSGIGRRIALQFAEEGANVVCASRSNEPHQGVHHDTDVARPTEQVIREDYDGDAIFVSTDVSDPDEVRNLVDETVDRFGGIDVLVNNAGVFVEGDSQETSVDDWQFMLSVDLDGTFYCCKFAIPHLKESSGHIVNIASVNATEGGSGPAYAAANAGQVNLTRDLAVELGPHDVNVNCLSPGYIKTPIQDYQDEESIQISREQTLLPELGEPEEVATVVTFLASEEASYVHGADIYVDGGWAAHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVR4</accession>
    <name>R4VVR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445240.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01975"/>
    <dbReference type="EnsemblBacteria" id="AGN00346">
        <property type="protein sequence ID" value="AGN00346"/>
        <property type="gene ID" value="L593_01975"/>
    </dbReference>
    <dbReference type="GeneID" id="16180336"/>
    <dbReference type="KEGG" id="sali:L593_01975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.401"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062622_0_0_2"/>
    <dbReference type="OrthoDB" id="87930at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="28961" checksum="077570B0B7F34707" modified="2013-07-24" version="1">MDVATSRDAVTPEAYLGVASVLVLIVLSATAMTVEPAPKLLVIGWVAFGAMAGGAVLGLRTRSEHPHGMVWGYGLAAGAMVTSAALFLIPQATAAAPRHGGLGVAIGLLVGFAGHTVGHRLTHLDLPMDRTVAELSAHSVSAGIIIGVIYAAMPDLGPLLGLAIVSHKGPAGYAAARRLVRSNRSVLPILLPSAGLGVAALAVSLVGGPAGADVQAVVFGFAAGIFLHVAMDFLPRCETGSEVHEHVVHQHDDDHDLLDRLRVHAVLSTGIGAVLVYLAWLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVX2</accession>
    <name>R4VVX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445305.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02300"/>
    <dbReference type="EnsemblBacteria" id="AGN00411">
        <property type="protein sequence ID" value="AGN00411"/>
        <property type="gene ID" value="L593_02300"/>
    </dbReference>
    <dbReference type="GeneID" id="16180164"/>
    <dbReference type="KEGG" id="sali:L593_02300"/>
    <dbReference type="eggNOG" id="arCOG02673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955130_0_0_2"/>
    <dbReference type="OrthoDB" id="41167at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="308" mass="33920" checksum="C65008CD88320B17" modified="2013-07-24" version="1">MARTARKVQELVAEGEDMEDALRTVHSVATANGGSVTWEDVDGDLTSGQWGRIIETGLLKSADDGFELTDPDGVSAALDGDADAEVVDLDFSDIPEIDEEAEEAASWSQWDKIAAVGAVMMMVGYYFDPVQNAVGGVIDLALGPLLDVLPFYLVIFAVALLTGLYSSLLMANLMDQETMSVYQDRMSAIQDKRKEAKERGDDEAVEQIQEKQMEMMGDQLGMMKSQFRPMVWVMLLTIPVFLWLWWTIGQGNVGTEGKPDMIMPLAGGVNWNEGIIGPMRAWIVWYIGCSFGFGQILRKTLNIRSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW13</accession>
    <name>R4VW13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446299.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01405">
        <property type="protein sequence ID" value="AGN01405"/>
        <property type="gene ID" value="L593_07290"/>
    </dbReference>
    <dbReference type="GeneID" id="16182087"/>
    <dbReference type="KEGG" id="sali:L593_07290"/>
    <dbReference type="HOGENOM" id="CLU_2217158_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="106" mass="11048" checksum="143F5EC55B79000B" modified="2013-07-24" version="1">MSLQTVFDRHRFGLYYGSLVLVGLSILAGQFPALLAASSPSDVSPLAAVLAVGGLVLATTSAWEALHSDRAEWEADQDEGRILVAVTIGFGALVAGVFVYVLLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW46</accession>
    <name>R4VW46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <shortName evidence="3">DHOase</shortName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrC</name>
        <name evidence="5" type="ORF">L593_02700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02700"/>
    <dbReference type="EnsemblBacteria" id="AGN00491">
        <property type="protein sequence ID" value="AGN00491"/>
        <property type="gene ID" value="L593_02700"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02700"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.547"/>
    <dbReference type="eggNOG" id="arCOG00689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_A">
        <property type="entry name" value="PyrC_classI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="53"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="460" mass="47862" checksum="F09BA96844D07AAE" modified="2013-07-24" version="1">MLIADATLPDGRTCDVRIEGERIAAVAESAESGDGGLDAAEDETVVDAAGLRLFPGAIDVHVHFREPGAGHKETWTTGSRSAAAGGVTTVVDQPNTDPPTVTGEALEAKRELAAEQSLVDFGINGGVTADWDPDSLFTADPFALGEVFLADSTGEMGIEGDLFADAVERAAVADTTVTVHAEDATLFDGDALEDAGDGVGRDADADAWSAFRTADAEAAAVERALAVAGDFDAAVHIAHTSTPEGIDLAAEAGATCEVTPHHLYLSRDDLDELGTFGRMNPPLRSAERREAVFERVVDGTVDMIATDHAPHTREEKEATIAEAPSGVPGVETMLPLLLATAAADDRLSYERVRDLTAANPADVFGLDRKGRIEAGRDADLVLVDPDATRPISGEDLHSNCEWTPFEGMDGVFPLATLRRGEVVYADPAAATGAAAVEGIDAIAPAADEFGSPNGDDVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWX3</accession>
    <name>R4VWX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08800"/>
    <dbReference type="EnsemblBacteria" id="AGN01705">
        <property type="protein sequence ID" value="AGN01705"/>
        <property type="gene ID" value="L593_08800"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1803"/>
    <dbReference type="eggNOG" id="arCOG00231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="68"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="34217" checksum="15F0F0EBC7742647" modified="2013-07-24" version="1">MADVPRKHLTMTDTAPPSASASGSDDEGATAEAATSEGTMDEGSEDALIDTDVSTDVTEGERQAETVIDTRDLSVYYGDEQALMPTTMEIPERRVTAIIGPSGCGKSTFLRSINRMNDLIDGCTVEGELNFRGKNVYDEDVDPVALRRTIGMVFQKPNPFPKSIRDNVAYGLRVQDKDDDVDEKVEQALKRAALWDEVKDQLDSSGLDLSGGQQQRLCIARAIAPDPEVILMDEPASALDPVATSKVEDLITELAEDYTVIVVTHNMQQAARISDKTAVFLTGGELVEFDDTQQIFENPEDQRVEDYITGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX57</accession>
    <name>R4VX57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09325"/>
    <dbReference type="EnsemblBacteria" id="AGN01810">
        <property type="protein sequence ID" value="AGN01810"/>
        <property type="gene ID" value="L593_09325"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1917"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="37701" checksum="F4E7406FC50180D3" modified="2013-07-24" version="1">MLGFVASATVSGLSSGRLETSVHAIRLDNAVFEGDNVVYLLDPREGPTTLIDAGVPTEPVREDLRAGLADAGVAIADLDRILLTHWHWDHSGLAGELQADSGADVFVHEDDAPLVDGSGRTDYQDLQRRLFERWGIPEAPLAELTGFLEGHDSLAGEPADVTTFTHGERFPLGAGSAPTDDGDADEDVLRAIHLPGHAAGLTAYAFERRAEAFVGDVILPKYTPNVGGADPRVERPLATYRSSLRWLAATDLDRAFPGHRDPIDDPATRAEEILTHHEERTERTRDAVDALGPATPWEIAAELFGGLSNIHIMHGPGEAWAHLEALVEDGEVERSDDDAVTRYRLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXA8</accession>
    <name>R4VXA8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="14">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="14">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">metG</name>
        <name evidence="19" type="ORF">L593_09625</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="14"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446764.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09625"/>
    <dbReference type="EnsemblBacteria" id="AGN01870">
        <property type="protein sequence ID" value="AGN01870"/>
        <property type="gene ID" value="L593_09625"/>
    </dbReference>
    <dbReference type="GeneID" id="16182768"/>
    <dbReference type="KEGG" id="sali:L593_09625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1982"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OrthoDB" id="6590at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="18">
        <location>
            <begin position="634"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="584"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="14">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AGN01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="732" mass="80762" checksum="597429B35239563F" modified="2013-07-24" version="1">MTTDDFPTDEPAVVTCGLPYANGDLHVGHLRGYTAADAFNRALNRIGQDSIYVCGSDMHGTPVAVNAWKEGVSPEEFALEWHEQYAETFPKFDVDFDNYGHTHDETNTELTRDIVRTLEDEGYVEERTIEVAWDPEEDQALPDRYVEGTCPYCGEHARGDECDEGCGRHLEPGEIVDPVSTITGNPAEYREREHKFFTVSKLADFLTEFLDGLEGTDNARNQPRQWIEEGLQDWCITRDLDWGIDYPAAEGSEAEGDGADADDLVLYVWVDAPIEYISSTKQYSERVGADEYDWEEAWKGSKLDGADGDGEAGEIVHFIGRDIIQHHTIFWPAMLHVAGYDTPRAVCATGFITINGKGLSTSRNRAIWAQEYLDEGFHPDLLRYYLTTNGGLQQDIDFAWEKFADRVNGELVGTLGNFCYRGTLFAHRNYDGTPDATVSEEVEAEIEDAIEAFRTAVNEYDVRGIGTAPVELARFGNEYIQRNEPWSLVDDEPEAAAQVIYDCVQLAKACAVLAEPVMPGKAEELWTQLGEKDSVHDVELEAALEAPSAEFDEPSELFEGVEDERVEELDAKLADRVAAADDAADAEDAAAVETDDADAATAADGEGAADADRTDEEAPDDLEPVLEDRISFEEFQGLDLRVGRIETAEGIEGADELVKLTVDIGVETRQIVAGLKQLHDVDELPGTKVIVMANLEAAELFGETSDGMVLAAGEQADLLTTYEDAVPGERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXB0</accession>
    <name>R4VXB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ubiA</name>
        <name evidence="7" type="ORF">L593_04760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445795.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04760"/>
    <dbReference type="EnsemblBacteria" id="AGN00901">
        <property type="protein sequence ID" value="AGN00901"/>
        <property type="gene ID" value="L593_04760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181081"/>
    <dbReference type="KEGG" id="sali:L593_04760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.973"/>
    <dbReference type="eggNOG" id="arCOG00478">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058976_0_0_2"/>
    <dbReference type="OrthoDB" id="71004at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="33614" checksum="740D0C77E6C9844D" modified="2013-07-24" version="1">MSEEHSEREGDSTETAAVRSDPERPDASQSSLSDVAVYLFALSRPRFWLYLAGPVLVGVVYAADARADLLTPATLALFAYFLVPANVYLYGVNDVFDADVDAENPKKDEREVRYRGQRFVPVAVAASGLGLFGVVSLTDPIAWPWLAAWGLLATAYSAPPVRFKTRPVLDSLSNGLYVLPGAAAYATVAGAQPPVWPLTGGILWTMAMHTFSAIPDVEPDREAGIATTATWLGERRTLAYCFTTWALAAAAFGMADLRAGAALSLYPLLVLGIAWSDVPVDRAYWWYPAINGVVGAGLTMWGLAQIVPPSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXD3</accession>
    <name>R4VXD3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 1-alpha</fullName>
            <shortName evidence="6">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tuf</name>
        <name evidence="8" type="ORF">L593_09775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446794.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09775"/>
    <dbReference type="EnsemblBacteria" id="AGN01900">
        <property type="protein sequence ID" value="AGN01900"/>
        <property type="gene ID" value="L593_09775"/>
    </dbReference>
    <dbReference type="GeneID" id="16180298"/>
    <dbReference type="KEGG" id="sali:L593_09775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2012"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OrthoDB" id="13117at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="45896" checksum="D57413F364A03419" modified="2013-07-24" version="1">MSDDLPHQNLAIIGHVDHGKSTLVGRLLYETGSVPEHVIEQHKEEAEEKGKGGFEFAYVMDNLAEERERGVTIDIAHQEFETDDYYFTIVDCPGHRDFVKNMITGASQADNAVLVVAADDGVAPQTQEHVFLARTLGIDELIVGINKMDLVDYDETDYKTVVSEVEDLLKQVQFNTEDAKYIPISAFEGDNIAEASDNTDWYDGETLLEALNALEEPEPPTDAPLRLPIQDVYTISGIGTVPVGRVETGMMNIGDNVSFQPSDVGGEVKTIEMHHEEVPEAGPGDNVGFNVRGIGKDDIRRGDVCGPADDPPTVAETFQAQIVVMQHPSVITAGYTPVFHAHTAQVACTIESIDQKLDPSGEGDGEENPDFIQSGDAAIVTIRPQKPLSIEPADEIPELGSFAIRDMGQTIAAGKVRSVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXE0</accession>
    <name>R4VXE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446804.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09825"/>
    <dbReference type="EnsemblBacteria" id="AGN01910">
        <property type="protein sequence ID" value="AGN01910"/>
        <property type="gene ID" value="L593_09825"/>
    </dbReference>
    <dbReference type="GeneID" id="16182821"/>
    <dbReference type="KEGG" id="sali:L593_09825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2022"/>
    <dbReference type="eggNOG" id="arCOG04626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078972_0_0_2"/>
    <dbReference type="OrthoDB" id="89564at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043859">
        <property type="entry name" value="DUF5821"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19138">
        <property type="entry name" value="DUF5821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="28925" checksum="A81DFD05C522CEAD" modified="2013-07-24" version="1">MVRNVYDDRIDGVLQRVFGEDDGPVYVADATAAVVEAVVDALSAIEDCPEVRLLAEDDAFKTVFADFLVGSEAADHVAAGRLSLRVAAEPGANPTVVASGRVTSLVDAGARVGGLRSDEAGLVEAARTNVEERWNASGEFSLRTPPMSTVREELSTDLDASVQEDFTGMLDSLETARGDDEDLDEVTVSLLAAAKNESLLYDISRWGEDTGVASKATFSRTKSSLEDAGLIETEKVPIEVGRPRLRLTLADERLRDAEPDQIAAAAQTVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXN6</accession>
    <name>R4VXN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445920.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05385"/>
    <dbReference type="EnsemblBacteria" id="AGN01026">
        <property type="protein sequence ID" value="AGN01026"/>
        <property type="gene ID" value="L593_05385"/>
    </dbReference>
    <dbReference type="GeneID" id="16181349"/>
    <dbReference type="KEGG" id="sali:L593_05385"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1100"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="34436" checksum="2D05AB188F4E2F13" modified="2013-07-24" version="1">MAAIRTEDLTKRYGDVVGIEDVSLTVEEGEVFGYLGPNGAGKTTTIRALLGFITPTSGSGEVLGADISDPTALREARADVGFLPSVMGFPEEVTGRRYLDHQARILGDERRDELLELFDPPLDRAIEEYSTGNLRMLGIVRAFMHDPDLVILDEPTSGLDPLKQSHFNAFVRGEVADGTTVFFSSHVLGEVRQVCDRVGILRGGRLVTVEPVDELLHRGGKRVRVVTDEPDRVGAGLDGAVERTVHDGEVQFTYAGDYQALLHHLAALDSVQDVEIAEPPLEDVFLHFYGEENEIGAEAATVADPAPAGTATGTEGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXV4</accession>
    <name>R4VXV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446999.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10800"/>
    <dbReference type="EnsemblBacteria" id="AGN02105">
        <property type="protein sequence ID" value="AGN02105"/>
        <property type="gene ID" value="L593_10800"/>
    </dbReference>
    <dbReference type="GeneID" id="16181925"/>
    <dbReference type="KEGG" id="sali:L593_10800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2227"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_2"/>
    <dbReference type="OrthoDB" id="56885at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="2">
        <location>
            <begin position="114"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="389" mass="40810" checksum="0C69BE980EF1B192" modified="2013-07-24" version="1">MPRLDSLDPATIRAGEATDAYFLRTEEALAAAGRDPTVVAEVTADQFPTGEFEVLAGLSDVAALFEGVPVDVDALPPGQCFDGGPVLQIEGRYRAFARFETALLGVLSQASAYATRALRARRAAPDSQVLSFGSRHIHPSIAPVLERAALVGGLDGISNVAAGERLGEEAGGTMPHALLMIFGEGNQAAGWKAFDEGVGPDVPRVALVDTFYDETVEAREAAEALGDALDAVRIDTTGSRRGDFRHIVREVRFELDAEGHEDVGIFVSGGIDREAMVRLRDHVEGFGVGSYLTSAAPIDFALDVVEVDGDPVSKRGKLPGRKAVHRTPDGGHHVALADAPAPEGGNSLLEPLVRDGEVVGDVDLESATDRARADAERVGFGVEAGSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY16</accession>
    <name>R4VY16_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">argS</name>
        <name evidence="12" type="ORF">L593_06010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446045.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06010"/>
    <dbReference type="EnsemblBacteria" id="AGN01151">
        <property type="protein sequence ID" value="AGN01151"/>
        <property type="gene ID" value="L593_06010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180134"/>
    <dbReference type="KEGG" id="sali:L593_06010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1231"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OrthoDB" id="7046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="482"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="605" mass="66297" checksum="400A1E609E82F2BF" modified="2013-07-24" version="1">MFRQLRAEAADAIEAALDAEGYPTGDLGLEEPPEDVDAVLASSVAFRLASEAGAPPPQVAGEIVATIEEQTDDCAALDLVDRVEPAGPYVNVFPSNAYLAGTIEAAADDDYGHLPDRDTSMVVEHTSANPTGPVHVGRARNPIIGDSVARLLDYAGYDVDIHYYVNDAGRQIATFTWAYETFDEADLAAAGYGAPERIKPDYDLVRYYRLGNEFLEGEHPDADEAAIEAAEDEIQAIMQGLEEADEATYERTTEVVDAVLSGMQDSLNRLPAEFDEFVKETKFMFDGSVEELMERMQALDEAVYEDDAWQLDLSAFGIEKEFVFQRSDGTSLYATRDIAHHEWKFEEYDRAVTVLGEDHKLQAQQLQATLDLLGNDTDRLDSIHYSWVNLPGGEGMSTREGTGIDLDDLLDEAVDRAREEYESRAADRLRDDDLDDSDVERIARQVGIGAVRYDIIAKQPTKAITFEWERALDFEAQSAPYLQYAHARCCGILGEAESAGIAVPEGDALASVDVDALEEPEARDLLLTIARFPAVIEAAADDLEPHVVATYVRLLADRFNAFYRSCPVLDADGDLQQARLGTVVAARTALANALDVLGVAAPESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYD0</accession>
    <name>R4VYD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-(Dinitrogen reductase) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446120.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06395"/>
    <dbReference type="EnsemblBacteria" id="AGN01226">
        <property type="protein sequence ID" value="AGN01226"/>
        <property type="gene ID" value="L593_06395"/>
    </dbReference>
    <dbReference type="GeneID" id="16181725"/>
    <dbReference type="KEGG" id="sali:L593_06395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1303"/>
    <dbReference type="eggNOG" id="arCOG04448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_8_2_2"/>
    <dbReference type="OrthoDB" id="74062at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="31665" checksum="DB6D6B8A48BC36FC" modified="2013-07-24" version="1">MNPNRAEGVLLGLACGDALGRPVEFDSPEQIADEHGTLTDMVGFGTWNQPAGTLTDDTEQALCIASSVAEHGSFDPADVAERFRTWYESEPFDVGVMTRRSLEALDRGAAWDEAGQSVWEDSPEGQNAGNGSVMRCPPLTIPLRNEPERLVEASKQSSQITHADPRCTWGCAALNLTIAGYLTDREAPLQWALDRIRSDAPDELVDALDPIAAGETPDSLSTSGYVVDTLQTALHDAIAADSASDAIVTAVNRGGDADTIGAVAGAVAGARFGAVDLDREWLVAIDETEAMRSLAIALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYM1</accession>
    <name>R4VYM1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01331">
        <property type="protein sequence ID" value="AGN01331"/>
        <property type="gene ID" value="L593_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06920"/>
    <dbReference type="eggNOG" id="arCOG06448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133601_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="159" mass="18019" checksum="608AF8529C058D2C" modified="2013-07-24" version="1">MAAIDSACDAFEYVGTGPPEFERDVARDEEWRTQLTKACRYLASCRALRAKDGFNGAVVELCFSAIERTIEAYLLRHTADSLASYRDHETVYERAAEHGVFERETAERLARLYRRNRTEHYYGGLVPTQAKEAAMFELAGQVHSYVTGLLEDEPVCQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYU1</accession>
    <name>R4VYU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02430">
        <property type="protein sequence ID" value="AGN02430"/>
        <property type="gene ID" value="L593_12455"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12455"/>
    <dbReference type="eggNOG" id="arCOG00512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124266_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15511" checksum="8F42B3883DAA0007" modified="2013-07-24" version="1">MDALEIADFLDTQHTGVLAMGRDDVGYGIPLSFAYDEDGPYVYFRLAYADGGQKREFVEAADSVAFVVHDDTEEGWKSVVAEGPIETQSETTFDAQLIEATKQLDIPYFSVHDRPAEGLEFVIARIDVADLTGVIEVGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZB2</accession>
    <name>R4VZB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_08255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446490.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08255"/>
    <dbReference type="EnsemblBacteria" id="AGN01596">
        <property type="protein sequence ID" value="AGN01596"/>
        <property type="gene ID" value="L593_08255"/>
    </dbReference>
    <dbReference type="GeneID" id="16181603"/>
    <dbReference type="KEGG" id="sali:L593_08255"/>
    <dbReference type="eggNOG" id="arCOG01235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_4_3_2"/>
    <dbReference type="OrthoDB" id="77144at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="13">
        <location>
            <begin position="121"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="35396" checksum="FA14B789195214E9" modified="2013-07-24" version="1">MAPDIAYPAAAVDLLLQSGYDGMTRVDVFSQIYLVFLALGTIVGTVVVTYTLYKVYKYRAGAGHDYDVGRPQLGELPTGADKGGRKLFLSFSLSAIIVISLIAWTYGLLLYVETGGAEVPEDGVEVEVVGDNFAWEFEYMDDETIPRDQLNDTVGVIGQQETAAALREARSDGSLSYSEALAARMDEASNDSVAASDVSTNVRAIGTFRIPVDREIHIDATSGDVWHNFGIPELRVKADAIPGEVSEQWFVAEEEGEYTAACYELCGSGHSGMNAQVIAMSNEDYQNWYQGQVIGIDTAIEQLEAGTYVQSASGSGNASASGSASGSAGGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZD8</accession>
    <name>R4VZD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447534.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02640">
        <property type="protein sequence ID" value="AGN02640"/>
        <property type="gene ID" value="L593_13505"/>
    </dbReference>
    <dbReference type="GeneID" id="16180705"/>
    <dbReference type="KEGG" id="sali:L593_13505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2762"/>
    <dbReference type="eggNOG" id="arCOG06229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024174_0_0_2"/>
    <dbReference type="OrthoDB" id="6449at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="732" mass="79886" checksum="5F364C3F96C6A12E" modified="2013-07-24" version="1">MLEWEATESGFRVHDSAGAECSVGGSQLEFTEPERELPRPVDITLDCLTTELTLPGAVVYLISLTSGETEELPGTTEPKAMPEGEYLVDVDAEVKTYLRLTGPFTLCRTADYDGVVLSVPARRRITLGFRSRNRKPTAELTIPPTPEGVATALTYSSAAHKTTGTDRSYPTLRGHPPLLEIADETADVEVPSAIREARDDTGIELLAPNAVESLLVLAPLAYYIGADVQVGNVASPILRAPDADVAHELPAMPDLERDATRLLRKVFFLDCLVRNAGPYDTELAEASLLDALGVDAETLYAASPADRLAAYLDVPYGAIEQRLPDWHCSTYVEPDRDGLRALPFLLDRMSLIYMPRTSELEGSELVERSLDDFYRGRSPEDYRSISSRSPRNVDTESAEREEAHGARSGDRTATSGDSDVRSAGDVASVDVLKPELRGGRIHGWLAEGTPIDVFNCLPEAFEHRIDALDRAGDGIDIAVVRNDAAMEVEHADVADIYRTRGADVSIDVSVHERLSTTELARLFEAEYDFAHYIGHCETGGFRCPDGHLSASSLTGCGLQTFFLNACGSYHEGVDLVRQGAVAGAVTFSQVLNDHAVSVGSTFAKLLVHGFGFERALQLARRRIMMGKDYAVVGDGTHSLAQSENRLPATVELESVEAGFLLTYDQFSSRHAGAFYRPYLGEDRYAYLCGNESDHVLDRSAVAAFLERAALPVIYDGDVYWSDDLADRIRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZG4</accession>
    <name>R4VZG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447554.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13605"/>
    <dbReference type="EnsemblBacteria" id="AGN02660">
        <property type="protein sequence ID" value="AGN02660"/>
        <property type="gene ID" value="L593_13605"/>
    </dbReference>
    <dbReference type="GeneID" id="16182528"/>
    <dbReference type="KEGG" id="sali:L593_13605"/>
    <dbReference type="eggNOG" id="arCOG03926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120317_0_0_2"/>
    <dbReference type="OrthoDB" id="111145at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="157" mass="16572" checksum="CDA272F1146DD66F" modified="2013-07-24" version="1">MTDDRAVSITVTHVMTIGITTILIAGLLLGAGNMLEDQRRSTGNQELRSIGDRHATEIVTATTSGLESNGNVTIHSRQPSSSVGGSYRVELTDRSSCFEESGYDGCLFLNASGRDIGVQVPIGVPSGVTVQDGSAQGGRVVIQYWTNDTVTIRGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZJ5</accession>
    <name>R4VZJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional malic enzyme oxidoreductase/phosphotransacetylase</fullName>
            <ecNumber evidence="8">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446565.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08630"/>
    <dbReference type="EnsemblBacteria" id="AGN01671">
        <property type="protein sequence ID" value="AGN01671"/>
        <property type="gene ID" value="L593_08630"/>
    </dbReference>
    <dbReference type="GeneID" id="16182602"/>
    <dbReference type="KEGG" id="sali:L593_08630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1768"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012366_0_0_2"/>
    <dbReference type="OrthoDB" id="3715at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="161"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="757" mass="81852" checksum="A1FED3680D169B76" modified="2013-07-24" version="1">MSLEDDSLEYHRSDPPGKIEIATTKPTNTQRDLSLAYSPGVAGPCREIDENVDDAYTYTAKGNMVGVVSNGSAVLGLGDIGAAASKPVMEGKGVLFKRFADIDVFDLELDLDDPEAMIEAIAAMEPTFGGINLEDIAAPDCFEIEETLRERMDIPVFHDDQHGTAIISGAALVNAARVVEKDLGELDVVFSGAGASAIATARFFVSLGVDPDRITMCDSSGIITAERAAAGDVNEYKAEFATEREGGDLADAMVDADAFVGLSVSGIVDEEMVRSMARDPMVFAMANPDPEIGYDEAKAARDDTVVVATGRSDYPNQVNNVLGFPFIFRGALDVRARDINEPMKVAAAEALAELARTDVPDAVRKAYGDQPLQFGPDYIIPKPLDPRVLFEVAPAVAEAAIESGAARVEEIDSEEYEERLEARLGGSREMMRVVLNKAKSDPKRVALAEGGDEKIIRAAAQLEEQGIAEPVLIGDESRIDETCRELGLRYDPEVVDPESNGGIGAEKREEYAERLYEARRRKGITRSEAEELIEESNYYASVMVDAGDADAMLTGLTHHYPSALRPPLQVLGTAPEANYAAGVYLLTFRNKVVFVADATVNQDPDEDVLEEITRHTAELARRFNVEPRAALLSYSNFGSVNTPGTVKPREAARRLREDPEIDFPVDGEMQADTAVVEELLEGTYEFSELDDPANVLVFPNLEAGNIGYKLLQRLGGAEAVGPMLVGMDQPVHVLQRGDEVKDIVNLAGVAVVDAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZR2</accession>
    <name>R4VZR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447634.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14005"/>
    <dbReference type="EnsemblBacteria" id="AGN02740">
        <property type="protein sequence ID" value="AGN02740"/>
        <property type="gene ID" value="L593_14005"/>
    </dbReference>
    <dbReference type="GeneID" id="16181011"/>
    <dbReference type="KEGG" id="sali:L593_14005"/>
    <dbReference type="eggNOG" id="arCOG00316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896071_0_0_2"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="294" mass="32526" checksum="F68296F756644C03" modified="2013-07-24" version="1">MLEPGAPAPTFSLPGAHDGEIDEFGLPAEPDRVHVVVFYPLDFSPACTREMCSLRDVELFGLERDVRLLGIGVDSAYSHRRFAEENGLGFPLLSDRLGDVAESYDVLAGEVEGHPRVAKRAIFVVDLHRTVQYAWSTDDPLEQPDLGQVTDAIEAIQDDRTSMHRYRDAHEQFQYGRSELDAARAAYHEKHWGLAIETFQEAQYYLDEAAEGFSSARRFAESDGIEAAAASAAEKARRLRQAADWFATAARNHGDGDDEAAEEYHDDATAAIEEVGELPSLKQEVDLDIAGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0N1</accession>
    <name>R4W0N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="9" type="ORF">L593_10780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446995.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10780"/>
    <dbReference type="EnsemblBacteria" id="AGN02101">
        <property type="protein sequence ID" value="AGN02101"/>
        <property type="gene ID" value="L593_10780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181555"/>
    <dbReference type="KEGG" id="sali:L593_10780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2222"/>
    <dbReference type="eggNOG" id="arCOG01306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_2"/>
    <dbReference type="OrthoDB" id="30571at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="411" mass="46155" checksum="CCDFC12B371EF966" modified="2013-07-24" version="1">MSHSPSLPDRPRLELDPEMDDEERLSALRDHYVEILEVHRQLREQLESADERRRELREEADRLERENETLKTTSLYVATVEEVDDGEAIVKQHGNNQEVLTEVSERMGERIDAGDRVAVNDSFTVKTVLDQETDARAQAMEVDASPQVSYADIGGIDEQVREVREAVEQPLENPEQFHEVGIEPPSGVLLHGPPGTGKTMLAKAVANETDATFIKMAGSELVRKFIGEGSRLVRDLFELASEREPAVIFIDEIDAIAAKRTESKTSGDAEVQRTMMQLLSEMDGFEERGEIRIMAATNRFDMLDRAILRPGRFDRLIEVPEPEAEGREKILEIHTRDMNVADDVDFATLAAETEGFSGADINSLTTEAGMFAIRDDRTVVREQDFHDALQKLQDSTTTDAITSDGYADYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W161</accession>
    <name>R4W161_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447195.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11790"/>
    <dbReference type="EnsemblBacteria" id="AGN02301">
        <property type="protein sequence ID" value="AGN02301"/>
        <property type="gene ID" value="L593_11790"/>
    </dbReference>
    <dbReference type="GeneID" id="16181580"/>
    <dbReference type="KEGG" id="sali:L593_11790"/>
    <dbReference type="eggNOG" id="arCOG01868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141432_0_0_2"/>
    <dbReference type="OrthoDB" id="88437at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15519" checksum="79698A0A2D6A462A" modified="2013-07-24" version="1">MAAIDPGADDGSEGFDTWKAMQVVTQETRASIVADVVGHPEGMPSVPELDYVNPDVHRSAISEHLDKLEDAGIVGKAEIPVGERSRDLPYVFYYVTDDARAFFDRNGIFDPDTWTDQYAKVEKTDAIERIEAMERPSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1D5</accession>
    <name>R4W1D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_12335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447300.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12335"/>
    <dbReference type="EnsemblBacteria" id="AGN02406">
        <property type="protein sequence ID" value="AGN02406"/>
        <property type="gene ID" value="L593_12335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181923"/>
    <dbReference type="KEGG" id="sali:L593_12335"/>
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    <dbReference type="eggNOG" id="arCOG02274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975282_0_0_2"/>
    <dbReference type="OrthoDB" id="69061at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="4">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="30931" checksum="D63CA3FB1063637C" modified="2013-07-24" version="1">MDRDTVSNVTRSENEHRSEDERRSGDEHRSADGNQSGDGDQSDDEHRSAAEHRPNHQRSPATAGRPLDDEPDLSEAVVSIPLDRLGELGMETLYERCTSAGLRDFSELVCSGGGCILHVVTEEPLPADELQALPYVAWWERLREPADGPATSIGKLLPAADASAVDSPAEHGVAPTEHAIADGRLAISLVGDRADLADRVREYERAGSTPTIERLGAYDGASAPLDALTERQETVLRAAHERGYFEVPRKTTTAEIADALDLDDSTVAEHLQRAQRSIVDDLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1H4</accession>
    <name>R4W1H4_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12610"/>
    <dbReference type="EnsemblBacteria" id="AGN02461">
        <property type="protein sequence ID" value="AGN02461"/>
        <property type="gene ID" value="L593_12610"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2588"/>
    <dbReference type="eggNOG" id="arCOG03105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770755_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043901">
        <property type="entry name" value="DUF5787"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19100">
        <property type="entry name" value="DUF5787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="42891" checksum="DF582496CBAEED9B" modified="2013-07-24" version="1">MVELRRIHRSSRTLTSAGDLHPLVTDWTREFPFELRVCRWAEHEWPPGEASLQPDQCVIVGRQLGTRERRWDTVVAICDAEALRTRAVFGERALDRNLLRVVRNAPFDFEWYRDALELWTTDWRYVREAVKDAADRDLIETRRRNNRIELRRRWEYPDWLEALIAIENKPDLDRSAADALADQMQRDVAFGLADEAWVATLKTGESAEPGLLADMPVEAGVLAVDPEAGDADVLWHPRSLAVEAPGTRIVDRPTGSEYDQSAAEFEYVDAEWKALARLAIAERLYERGWRSYVDSMQPDCRHFELETVGEDGTAALQPHCAAKQTCPTSWECSGRCSEYEPEPPAWRSKGWPIEGGPGKGLRSVLEARRARKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1T0</accession>
    <name>R4W1T0_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447500.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13335"/>
    <dbReference type="EnsemblBacteria" id="AGN02606">
        <property type="protein sequence ID" value="AGN02606"/>
        <property type="gene ID" value="L593_13335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181388"/>
    <dbReference type="KEGG" id="sali:L593_13335"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2728"/>
    <dbReference type="eggNOG" id="arCOG03887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773133_0_0_2"/>
    <dbReference type="OrthoDB" id="105319at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024464">
        <property type="entry name" value="DUF2391"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09622">
        <property type="entry name" value="DUF2391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15032" checksum="8DBF99D2B7216A4D" modified="2013-07-24" version="1">MARFRPRRRFRIADSAQQVVGGFLLAGPFVVTEEVWTLATNMNAIQALVTVAIVFSIGYAALYKAAGRDSEDDVDVAGVPVRFVSLMIVSYGSVAVLALTFGAPETFLAEHGDVERAYITVKAIGVGAIFSVVGAATADSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W269</accession>
    <name>R4W269_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447630.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13985"/>
    <dbReference type="EnsemblBacteria" id="AGN02736">
        <property type="protein sequence ID" value="AGN02736"/>
        <property type="gene ID" value="L593_13985"/>
    </dbReference>
    <dbReference type="GeneID" id="16180990"/>
    <dbReference type="KEGG" id="sali:L593_13985"/>
    <dbReference type="eggNOG" id="arCOG11959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152721_0_0_2"/>
    <dbReference type="OrthoDB" id="116481at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="111" mass="11837" checksum="61E4879818B23A0B" modified="2013-07-24" version="1">MSQGITHFAVGATVTVLLVTVAIPTVRYPRTWTLVGGGWALVPDASKLHAVPETLAFHDSILANVCWAHRTLDRLDPGDSTTWASAALLALFGATVLAERRSYRTPAPIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W279</accession>
    <name>R4W279_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14060"/>
    <dbReference type="EnsemblBacteria" id="AGN02751">
        <property type="protein sequence ID" value="AGN02751"/>
        <property type="gene ID" value="L593_14060"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2877"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="385" mass="42576" checksum="60EE491729D41F70" modified="2013-07-24" version="1">MTQTITDYELYEVPPRWCFLKLETSDGRVGWGEPVVEGRSKTVRAAVEELLDGYLLGEDPDRIEHHWQRMYRGGFYRGGPVLMSAIAGIDQALWDVKGKQFDAPAYELLGGAVRDRIRVYQWIGGDRPAAVGDAAAEQVDAGFTALKMNATSELRRIDTPAAVRAAENRLEAVRNRVGPEVDVGVDFHGRVSKPMAKRLVEALEPHEPFFVEEPVLPEHLDGLGEIAQHTTTPIATGERLYSRWDCKQLFEDGHVDVIQPDLSHAGGITECKKIADMAAAYDVALAPHCPLGPIALASCVQVDAVAPNALIQEQSLDIHYNETSDVLDYLADPAVFEYDDGYVTLPDGPGLGIEIDEDHVQEMAEQDVDWHNPVWTHEDGSVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W296</accession>
    <name>R4W296_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coenzyme PQQ synthesis protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_14185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447670.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14185"/>
    <dbReference type="EnsemblBacteria" id="AGN02776">
        <property type="protein sequence ID" value="AGN02776"/>
        <property type="gene ID" value="L593_14185"/>
    </dbReference>
    <dbReference type="GeneID" id="16181112"/>
    <dbReference type="KEGG" id="sali:L593_14185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2902"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027626">
        <property type="entry name" value="Pseudo_SAM_Halo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04347">
        <property type="entry name" value="pseudo_SAM_Halo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="44055" checksum="4947757942B6A15E" modified="2013-07-24" version="1">MISISKLLCGGEAEGDGLRYDAAGESRKPQIRERKQRRPVVVWNTTKQCNLYCSHCYAGAEDASAPGELSTAEGKALLEDLAAFDVPVVLFSGGEPLVRDDLEELVAYASDLGIRPVLSTNGTLLTEGRVEALRDAGLAYAGVSVDGMPEHNDEMRGQEGAFDAALRGIRTSLDAGLKTGLRYTITEENADDLEDVIDLLHEEGVDRFCFYHLDYGGRGAEIADADLAPEDKREAVRTLCDLTREYHDRGDEIETLLVGNYADAAFLVEYARSELGGDAAERIRAYLERNGGDPTAERVADVDYQGNVHPTQFWQSYSLGNVRDRSFGDIWTDETNPLVRRLREREDHLTGRCASCQYRSICRGGSRLRALAASDDPFGPDPQCYLSESEREPGGAGDLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2J1</accession>
    <name>R4W2J1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cofD</name>
        <name evidence="4" type="ORF">L593_00185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0</text>
            <dbReference type="Rhea" id="RHEA:63444"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444886.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00185"/>
    <dbReference type="EnsemblBacteria" id="AGM99991">
        <property type="protein sequence ID" value="AGM99991"/>
        <property type="gene ID" value="L593_00185"/>
    </dbReference>
    <dbReference type="GeneID" id="16181076"/>
    <dbReference type="KEGG" id="sali:L593_00185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.37"/>
    <dbReference type="eggNOG" id="arCOG04395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055795_1_0_2"/>
    <dbReference type="OrthoDB" id="31831at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGM99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="35115" checksum="863320E8AFF94134" modified="2013-07-24" version="1">MVTFLSGGTGTPKLLDGAAVAYEPEETTVIANTGDDIELGGLLVSPDLDTLLYQGGGVLNRDRWWGIGGDTTRTHDGLHDIGKAMGLEAGPRYLADDAQTAGRDIADWRRFSGAVEFMEIGDRDRSVHVTRTSLLDEGHTLSEVTERLCEAFGVTLELLPMSDDPVASLVHTPEEVMHFQEYWVARDGEPDVENVEFRGSSTAEPAPGVLDALEDDVVIGPSNPVTSIGPMLAIDGISDALAQTTVVAVSPFRGDEAFSGPVADLMDAVGAVPSTEGIATAYPFADAFVIDEDDDANFDRPVVRTDIEIDGREDAARVVQAVERALDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2R7</accession>
    <name>R4W2R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445001.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00760"/>
    <dbReference type="EnsemblBacteria" id="AGN00107">
        <property type="protein sequence ID" value="AGN00107"/>
        <property type="gene ID" value="L593_00760"/>
    </dbReference>
    <dbReference type="GeneID" id="16182084"/>
    <dbReference type="KEGG" id="sali:L593_00760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.155"/>
    <dbReference type="eggNOG" id="arCOG01163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_2"/>
    <dbReference type="OrthoDB" id="33452at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="34309" checksum="5499EBC34DA324E9" modified="2013-07-24" version="1">MTHEIAVIPGDGIGQEVTPAAVEVLEALPVDFDFVEGEAGDAVAAETGEALPEETRELAADADATLFGAAGETAADVILPLRSVVGSFANVRPARSYPGLEALQPDADIVFIRENTEGVYTGIESEITDGVRTLTRVVTEDASRDIAEYGFEYARRNDFEHVTIAHKANVMRQTDGLFLEVAEQVGEEFGMDYETALMDALAMHLVQRPEEYGVVICPNLAGDMLSDLSAGLVGGLGLLPSANVGEENALFEPVHGSAPDIAGQGIANPAAMILSAAMLLEHFEYGDEAAKVRSAVEDVLAAGPRTPDLGGDANTQDVTAAVIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V9</accession>
    <name>R4W2V9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445086.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01195"/>
    <dbReference type="EnsemblBacteria" id="AGN00192">
        <property type="protein sequence ID" value="AGN00192"/>
        <property type="gene ID" value="L593_01195"/>
    </dbReference>
    <dbReference type="GeneID" id="16180281"/>
    <dbReference type="KEGG" id="sali:L593_01195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.243"/>
    <dbReference type="eggNOG" id="arCOG03050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_19_1_2"/>
    <dbReference type="OrthoDB" id="114597at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="15574" checksum="673B3D42DD3EFB50" modified="2013-07-24" version="1">MERALVVIEASEATKNLVAEAAELAHGVDAELRLLYVTSDEEFEERQGELSSIPGIELDYGVARGVEEAEGFAEAIGEEVLGADAEFTAVGRIGDDEEEILAEARSSDADHIFVHGRQRSPAGKAVFGDIAQAIILGFDGPVTVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W323</accession>
    <name>R4W323_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonuclease/rho motif-related TRAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445161.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01570"/>
    <dbReference type="EnsemblBacteria" id="AGN00267">
        <property type="protein sequence ID" value="AGN00267"/>
        <property type="gene ID" value="L593_01570"/>
    </dbReference>
    <dbReference type="GeneID" id="16179848"/>
    <dbReference type="KEGG" id="sali:L593_01570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.319"/>
    <dbReference type="eggNOG" id="arCOG01643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1639934_0_0_2"/>
    <dbReference type="OrthoDB" id="103175at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16596" checksum="2369149C0A4930DD" modified="2013-07-24" version="1">MANCPLADECPSFSERIEGMGCTHYGDRGGKEWCNHYSQPIDDLKTQPVKQGEEVVVDVEDIHESGAGVGRTDDGFVVLVDGVLPDARAKVEITKVHSNHAKADELERLPMEPDEEETAEDAEATDEAEDAEDEDERRPHLGSREDFWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3G8</accession>
    <name>R4W3G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445416.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02855"/>
    <dbReference type="EnsemblBacteria" id="AGN00522">
        <property type="protein sequence ID" value="AGN00522"/>
        <property type="gene ID" value="L593_02855"/>
    </dbReference>
    <dbReference type="GeneID" id="16180356"/>
    <dbReference type="KEGG" id="sali:L593_02855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.577"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OrthoDB" id="105393at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="341" mass="36563" checksum="AE8619F67846063D" modified="2013-07-24" version="1">MRGSVTLGDGVRIETAIGDVVADGKRPSGDLAVTSHAHSDHLPSVASASDTPAICSPLTANLAGVRRSEALTVAEHPDVTLLPAGHVAGSRAVLIDDGETRYCYTGDVCTRDRCHLDGFEPPDADVLIVEATYGRPGYVFPDHDEIEREIFAWLTETMDRPVVLVGYALGRAQKLQEIVSRSDRTRCLVSEGVAAVTDPIEAALGVDFGAEPFDPETSADGRDAGSPGTEPTLEPGDALVVPSNVRRSERVQQLVEETGALTAGFSGWAAGSSFRYRGDYDATFPLSDHCDFEELLELVETADPDAVYTQHGFTDDLAEALVDRGYRARSLKRNQTTLADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Q5</accession>
    <name>R4W3Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445576.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03655"/>
    <dbReference type="EnsemblBacteria" id="AGN00682">
        <property type="protein sequence ID" value="AGN00682"/>
        <property type="gene ID" value="L593_03655"/>
    </dbReference>
    <dbReference type="GeneID" id="16180647"/>
    <dbReference type="KEGG" id="sali:L593_03655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.742"/>
    <dbReference type="eggNOG" id="arCOG00644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_2"/>
    <dbReference type="OrthoDB" id="67633at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="29264" checksum="D725954ED485E28B" modified="2013-07-24" version="1">MSDDAGGSAEDVPANDRDDAALGTVYLVGSGPGDPELLTVRAKRLLESADVVLHDKLPGPEIIEAIPPEKREDVGKRAGGERTPQSEINERLVEHAQAGRDVVRLKGGDPFVFGRGGEELQYLADHGVPVEVVPGVTSPIGGPAVAGIPATHRDHASSVTLVTGHEDPTKEESAVDWDALAATGGTLVVLMGVGKLPEYVAALREAGMDADTPVALVERATWADQQVATGTLDTIETVRDEAGIEPPAVTVIGEVAATREQVLDALRSPYGTDRSPEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Q8</accession>
    <name>R4W3Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445581.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03680"/>
    <dbReference type="EnsemblBacteria" id="AGN00687">
        <property type="protein sequence ID" value="AGN00687"/>
        <property type="gene ID" value="L593_03680"/>
    </dbReference>
    <dbReference type="GeneID" id="16180651"/>
    <dbReference type="KEGG" id="sali:L593_03680"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176006_0_0_2"/>
    <dbReference type="OrthoDB" id="129932at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="87" mass="9165" checksum="C165A5564C16BBD9" modified="2013-07-24" version="1">MAATGTCDGTDARTALADLPPSAKLVATVLAHEGELTQAQLAEETLLPPRTVRSGLSELDSAGLVDSRISFVDARQRIYDLDGTLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3T7</accession>
    <name>R4W3T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase subunit J</fullName>
            <ecNumber evidence="2">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445611.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03830"/>
    <dbReference type="EnsemblBacteria" id="AGN00717">
        <property type="protein sequence ID" value="AGN00717"/>
        <property type="gene ID" value="L593_03830"/>
    </dbReference>
    <dbReference type="GeneID" id="16180632"/>
    <dbReference type="KEGG" id="sali:L593_03830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.777"/>
    <dbReference type="eggNOG" id="arCOG04654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170071_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9114" checksum="A4DF1FF5FD6842DB" modified="2013-07-24" version="1">MVLDTIAFALLAAVLVGSSLGAVTVRDVWHAALLLGVSLVTVAALYVTLAAEFLAAIQVLVYVGGVLILITFAVMLTRRAGEDEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W443</accession>
    <name>R4W443_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04765"/>
    <dbReference type="EnsemblBacteria" id="AGN00902">
        <property type="protein sequence ID" value="AGN00902"/>
        <property type="gene ID" value="L593_04765"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.974"/>
    <dbReference type="eggNOG" id="arCOG01521">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="346"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="569" mass="61646" checksum="F1FA6429D45F0474" modified="2013-07-24" version="1">MTDLGDRSVAVIGSGFGGLSTACFLADAGADVTVYERNEQLGGRASRLYRDGFRFDMGPSWYLMPDVFERFFAYFDREPTDYYDLTRLDPHYGIYFKDGDSIDVPADHRAAIPLFEEYEEGAGAAFEDYLAEAQRTYEVGMEHFVYHDRSRPADWLDPGLAKHGRGLSFLGSMEDHVADYFEHPKLRQIVQYSLVFLGGSPSNTPALYNLMSHVDFGLGVWYPEGGLGGVVDAIVELGTELGVEYRVNCDVTAIRGREGGFSLDVERTAGAERFDPVADVPGEVPPAIAIPEDGPPAGNRRLVPRSDAAGRTPVANGGTASATDGSASANGGTASATGGATSAAVPADLVVSDADLAHVETELLDDDRRDREPAYWDDRTYAPSAFLLYLGVEGDVPNLDHHTLVLPPEWDGHFDQIFKEPAWPDDPAYYVCAPSVTDDSVAPEGHSNLFVLVPIAPGLDDDEATRQAYRDQVLADLAEHSGEDVRDRIVVEESFCVSDFGERYNAAKGTALGMAHTLTQTAVLRPSHRSSAVDGLYFTGSYTTPGIGVPMCLISGEHAADKVLEDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4B2</accession>
    <name>R4W4B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05365"/>
    <dbReference type="EnsemblBacteria" id="AGN01022">
        <property type="protein sequence ID" value="AGN01022"/>
        <property type="gene ID" value="L593_05365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05365"/>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="467"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="620" mass="68872" checksum="22F65FE2BD620EFB" modified="2013-07-24" version="1">MNPISRRGLLQTGAALGTVAGLPLAAASEESDGDHHASWDGSPDLEKFAQPLPIPETREPDGRDRGAPYHEVSVEAGTHSFHPDIPDSKILGFDGQFPGPIIESWQYRRLRVHFDTSDLPTEHVFEVDEEIRGTTTENYHDYDGPVPEVRQVTHFHGLNTPTASDGQADMWTSPEGVTGPRFSEPVQEIPNRNARMSTVYHDHARGISRLNNYAGLVGPYIVKGWRERHMGLPEDEHDVPLVLADRAFHEDGLLYYPDEFVANFAGDVATVNGAAWPTFEVEPRRYRFRILNPSNGRTYGLNLASEGDGHDGDSGDHDDGGEGLSMYQIATGHGFLEEVVEIGHGGDMETLVIAPFERAEVVVDFSDHAGETITMTNDAQFPYSGGSHGDGHDGGMGNMDSDGEMGGDDGHGGGDHPQIHEIMQFEVAEESDGWDRTRHPTDLRMPYRHTPTERAAQETRQISMEMQMGSDPGLHTLNDKRWGDPIEIEPQLGTTEVWEISNTSMHTHPLHLHLVEFTVIGRGQDGTEPPHPNERGGKDVVRVNPDETVRIAVKFGDFAGKYPFHCHVLEHEEHEMMRMFEVVNGHDRGNGRGRGHDREDDDDDDREWGDDDDDDGRGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4C3</accession>
    <name>R4W4C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dihydrolipoamide dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_05465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445936.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05465"/>
    <dbReference type="EnsemblBacteria" id="AGN01042">
        <property type="protein sequence ID" value="AGN01042"/>
        <property type="gene ID" value="L593_05465"/>
    </dbReference>
    <dbReference type="GeneID" id="16181363"/>
    <dbReference type="KEGG" id="sali:L593_05465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1115"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_2"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="9">
        <location>
            <begin position="355"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="473" mass="50414" checksum="4534CF2B2CA9BF0B" modified="2013-07-24" version="1">MDEVDFLVIGSGSGLDVANAAANQGQSVAVVEKGPLGGTCLNRGCIPSKHLLYHADVLETVERAGEFHVEATVEDVDFSEIVQKVNEEVQDDAASIRQGLRSSPHHDLFEGEGRFVDDRTVEIVSGEDEGARIRAETVLIAAGTRPAIPDVDGIDDVDYLTSTEALQLETPPEHLVIVGGGYIAAELGHFFGTFGSDVTIVGRRPNLLPEADQEVAEAFTDRYAERFTVHTGHAATGVSETDGTVTVEAHPYEYGPAGGLSEDDAVTATGDELLVAAGRRPNTDLLDLDATGVDTDDRGFVETDEYLRTTAEGVWALGDIVGEHLLKHSANHEAQAVARNLFGDELQAVDYTAMPFAVFASPEVAGVGARKEELEAAGREYATRTYRYEDTARGSAMQAEGFVKAIIDLDGQILGCHVIGPDASNLIQEVVVAMKAGSGSVQDIRESVHIHPALSEVVQRAFSGQFTRGGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4N0</accession>
    <name>R4W4N0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446101.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01207">
        <property type="protein sequence ID" value="AGN01207"/>
        <property type="gene ID" value="L593_06300"/>
    </dbReference>
    <dbReference type="GeneID" id="16181684"/>
    <dbReference type="KEGG" id="sali:L593_06300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1286"/>
    <dbReference type="eggNOG" id="arCOG00805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="770"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125323" checksum="D901AF2636D11610" modified="2013-07-24" version="1">MTEAASLLAGPDPDAATRRAFHWADAEADDAPDAVLCLTQSTDRADELERRWAEDRNPLRFTATTLDRFVSGCYERATGSLADTTLSKPERLRLVEAAIERFDGGDGPFGAIEQPTNALVDQVQGLFSLLEYAGYATPDEMEQALRSAGAVGDDALDPDLFASFRSTEITDGDGTLESQAAIIPELYAEYQSLREELHPDWKTVNSEQYLALLDGDQLLDAVPASVDAVVLDGLTRLAPAERETIARIGRNLPTVAVLSLVHDSMGGNGLDFGVQQELTVYQAIGFQLDYKPPESVDDRRLDAVRSLHVASRDPRSYAPSEVGIEWLEPSTEREEVRTIARRIRGLLARNDVDPSDVGVVVTDRTTYRGILAETLGGYDVPFTFTNDIGIEQTLVGDAVEGLLDLADGESGVTPLRSLCSNALVSLEAFGVDPAAVRRAKESADGDSIEALLDALEDDEAATTAVGIEDLRDRVDPDGASLAGYVKELGDLLEDLTVGEAVEEHGSPSTATGSHRPAYERSAWESVEGVLDSLEAIAPKVSDEEPVGRGRRALRAELVGGPSQRDGYVRVLPMAEAEMASFEHTFVLGLTSGYFPTEQDTMAFFGAVNDADEEFSRAHTGRRARYILGTLLTGSGQVVLSTPRHSVDGVEHVPAPVVTELRRYVDGPSDGDEAGRSVWPTDGAPDGAPSVTSEDVQRRYAKWAGPQSFDSVDEPVAALDGADGLTDDGRTFAERGLTTAWRRAQPHHTAHDGHIGELLEEIYPSWRREPYSPSALENYARCPFLYLANNVLGFDEDYGEENDVSRADRGIFIHEVLADFYRELREEAHSPVALSEFDREHLESELLSKSLARVDELGSIETPFARRTVTRILAGLGSPSENPYYGPSHDGADGLFVRFLDAELESADGAHARPTYFEGAIGIDYLDDVELLAEEPVTVETPDGPVDVSGIADRIDVVPDGASPHLPDGVRGIYVRDYKTGNTPARADVTDGTKLQLPLYGLALEEILEDATGIPHEAIGGSYYGLKSPTDVDPTAGQVTSKAAVGSDDGLPLVTPTGQTWRLPFDDVEQHRRFIRDVTSSRLGRIASAIDDGAFHTTLLSADHADCEDCTFRNSCDVRHHLRQDQLDEIDEGEHYVSERARDAELDLDAYGAGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4S2</accession>
    <name>R4W4S2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phhB</name>
        <name evidence="5" type="ORF">L593_06775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446196.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06775"/>
    <dbReference type="EnsemblBacteria" id="AGN01302">
        <property type="protein sequence ID" value="AGN01302"/>
        <property type="gene ID" value="L593_06775"/>
    </dbReference>
    <dbReference type="GeneID" id="16182828"/>
    <dbReference type="KEGG" id="sali:L593_06775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1384"/>
    <dbReference type="eggNOG" id="arCOG02939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_3_2_2"/>
    <dbReference type="OrthoDB" id="120013at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10376" checksum="2B12BBB16C32136E" modified="2013-07-24" version="1">MADVLDEADIEAGLPEGWEYADDEITRTYEFDEYLRGVAFAQLVGEIAEAQFHHPEIVIRYGEVEISLTTHDAGGVTQQDLDMAEIIESETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W506</accession>
    <name>R4W506_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_07485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07485"/>
    <dbReference type="EnsemblBacteria" id="AGN01442">
        <property type="protein sequence ID" value="AGN01442"/>
        <property type="gene ID" value="L593_07485"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1530"/>
    <dbReference type="eggNOG" id="arCOG00702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229417_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2350"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="195"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="8">
        <location>
            <begin position="867"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1439"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1535"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1828"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1926"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="2233"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2118"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2321"/>
            <end position="2342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="2381" mass="244611" checksum="F2395E99478D84C9" modified="2013-07-24" version="1">MPTLEEGSTGLRSAVDATAEVGSDAGVESGTTSREDLAGGDGAGGPPVDPALENATGETEVIVRFEEARNTPGASANSVSELQNHAEQTQSSFERYARTTDAVEIQRSFWITNAMLVQMNASELPPGQLLQFQNVERVHRNFEVRALSTEADPLPSSTDQPSATAHGGTAPYNGTYGLHVVNATRTWEEFGTMGGGVNVTVLDTGVNTTSTDIDISAWAEVDGYGNVVDTNVSNATDSDGHGTHVSGTVAGGNASGQYIGVAPNATLKHGQVIPGGGGSFAQIVGGMEWATNDTDSDVITMSLGATGYHSELIAPVRNVRDAGIPLFVATGNVGEWNSDSPGNVYESISVGAVDSSLDVAGFSNGEWIDTSVAWDGDAPDSWPSRYTVPDVVAPGVDVLSINGSSGAYEQFNGTSMATPHVAGVAALVLSVNGTLNDSEVERTISETAFEPHNYEEPDHRYGTGVVDALNATASVTRNTTVSGWVTNATSGAGIADALVETEYGLRTRTNATGYYEFEVPSNNQTITADPLGFEANGTAVNATGQASVQQNITVSTEIVEARIVERQARYTNSSAGLNVSYRVANVGNYNSSLFYHNPLPTPSTATLRVDGNAVSFGQNVSLGIDGPTTVNISVTTNDGYFGILSLEQSFYGEGGSGVVADTIGPSTYHDDPVEIPEDLNPSALQTPIDYVEKNTTLVLNDTTTYEEQIGTYLGSGTYTAIILRNRVSLAAANGADPLVNFTDVTHLVDIGLLVSEPDTSVTGITFDGNGATGVLDVEATGAEIRNATIRDGADGIYLGTGVTDAISNNRFQNLLNGVYADGGDVRSVDNNTATGIADHGIHLPDSWTPNTTIADNDLTIDSGATAGINASTNVSSISGNQITLNGSSADGIATGGAPESTGTVTIADNVISGGYVGIEVGDPGADVIRNNSISDTQWRGISVGWTYRSSATVAENDIRNVDLQGIVSDPSINTVFHNNTIDGVGQFGIEIRDNGPTSDSNVTISNNTIVNVDPSGGHTSRAVLVFQLGNAEIVDNNVSDGRIRVESGANVTARRNTVTNAPVGFDVTRNSSNVRSEHSTFTDVGLVFQTSSLFGYTPTNVTFADANVTTANGTVHIADVPAEDVDVTNLSLADGTRVDASGHNASLELGQDPSNSTFPADYGDIGAFLNLSEEGPGSQIDVNVTYDDADASGLREDTLEVHRYNGTGWETVSTTGVDTATNDVWASVTSFSTFAPLAEETQGTFNVTSVESNASTVLEGETVQVNATINNTGDRSGTQNVTLDVNGSVGTVDHENVTLDPGNETTVSLNWTTQSGQAGDYDATVTTAQDTNSTAVRVDAPANFSVNVTGSNSPVQEGETLDVNATIENVGDRNATQTVNLTAGGTQRDSQSLTVNATESKHVTLQWATTDGDAGDYTANVSSENDTDGASVTVQEPANFSVTNVTTNAPVTEGETLDVSATIENVGDVEGTQTINLTVDGTEETTQSLTLNAGESSTETLSWTTTAGDNGTHTVAINSENDSASTTVTVQTPANFSVQIDDTNSAVVEGDTLQVNATVNNTGGTTATQNVTLALNGTQEDSESVSLNGGENQSVTLNWSTTDGDAGDYTAAVNTSNDSATTSVTVQEPANFSVTAISSNAPVTEGANLTVDATIQNVGDVSGTRNITLALNDSVGVQDYQSVSLGAGNQTTLTLNWTTAGGDAGDYNATVNASDDSNATSVRVDAPAYFAVESVTSPNAPVVEGETLQVNATINNTGDLSATQNVTLELNGSVGVVDNQSVSLGAESQTTIALNWTTADGDVGDYTASVNSSNESTSTSVRVDEPANFSVTVDSTNSPVVENDTLQVNATIQNVGDRNGSQTVNLSINGSVGEVDNQTITLDVGESTTHTFNWTTGSGDNGNYTATVNSANASASSPVEVLAPANFTVNVTGSNSPVTEGDTLQVNATVNNTGDVAATQNVTLELNGTGDVASQNVTLDGGNAIAIALNWTTDGRDAGNYTATVASDDGNDTVAVEIQDAAVYFEVSNVSAPGSITEGDSYTVTANVTNVGSANATQNVSYLLGGTVQTTETNVSLNASERVEVTFSATNGTPGEYTQAIRTANETVATANLTVNAESSGGGGGGGGGVFLPPPSDDGGPSFTITSIDLASDEVGVGESVSVDVRVDNDGNEDGEYTATLTADGQTVDSETLSINANWHETFTLSATFDEAGTYQLAIDGESAGTVTVTGAADLVVTDRRIDATEVDAGQSVTVTTIVSNEGSGEGSRTVELVVGGETVASETVTLAPGESATVTLEHTFAESGSYDVSLGGEQLQTVEVSESQADDGSGDGDGGAGGDGGGDDGGFPVLLVLGVLGVLVAAGSIGFFVYGDELAELLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5L1</accession>
    <name>R4W5L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09235"/>
    <dbReference type="EnsemblBacteria" id="AGN01792">
        <property type="protein sequence ID" value="AGN01792"/>
        <property type="gene ID" value="L593_09235"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1896"/>
    <dbReference type="eggNOG" id="arCOG00134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_14_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="40433" checksum="851299CBD386EBD4" modified="2013-07-24" version="1">MQVFGSLCAMVFLVNLGRVIFAPLVQPLSDAFGLSGGSIGLIVTLAWLGSAVPRLPAGYALTRVPRHYVILAAGIGLTVAAVLTAAAPSPIAVGIGAFLLGLASGAYFIAANPLVSELFPNSVGRVLGIHGASAQIAAVLAPLAVTAVLAIATWRGVFVVIAVVGALGTAAFFVAARRADLPDAGSEDREILAAVRRQWRLILTGIVLIGVVGLVWNGVFNFYATYLEDVKGLSRGTANLMLTVVFAAGVPAFYAGGQFADRFEHVPVVLAVMTGFTVGLFALTAASGLAAIVAASVLIGFIIHALFPAMDTYMLDTLPDEHRASAYAVYSATMMLIQASGSVVVGTLTDYGVGFDALFLGMGVIVLGFVAVMGTLYLSGHLPTGGKAHRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Q8</accession>
    <name>R4W5Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_09710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09710"/>
    <dbReference type="EnsemblBacteria" id="AGN01887">
        <property type="protein sequence ID" value="AGN01887"/>
        <property type="gene ID" value="L593_09710"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1999"/>
    <dbReference type="eggNOG" id="arCOG01628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049427_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="265"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41212" checksum="92DF27A779B90D8F" modified="2013-07-24" version="1">MDTGLSTRDRAIINAYQGGFPVVADPFDAAAEALRERGAEAGFDEIADIDADELLDRIAQLDDDGTLSRFGPLVNADEIGGTATLVAIHAPEDRYDEVVEAINDFDEVAHNYAREHPHLNVWFVVSVADADRVDDVLAEIEAETGQEPYNLPKLQEFRVSAHFPVEGPLEGDGIDLTDVGAGAEFDADSAAAAGEADASEDDGLSVAELDLVAAVQDGLPLTRTPYADVAAELGQPAEWVRETLARFEATGKIRRIGVVPNHYALGYSENGMTVWDVPSEDVTAVGETVAALPYVTHCYERPRHEGVWPYNLFAMTHGRSEAESEARIEAVRETIADLTEVRQWDTLFSTEILKKTGINVAERAAADADGDEESAQTARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W2</accession>
    <name>R4W5W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-L-isoaspartate O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446866.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10135"/>
    <dbReference type="EnsemblBacteria" id="AGN01972">
        <property type="protein sequence ID" value="AGN01972"/>
        <property type="gene ID" value="L593_10135"/>
    </dbReference>
    <dbReference type="GeneID" id="16182383"/>
    <dbReference type="KEGG" id="sali:L593_10135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2089"/>
    <dbReference type="eggNOG" id="arCOG01780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346390_0_0_2"/>
    <dbReference type="OrthoDB" id="85994at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="22695" checksum="10B9F6E7CCE47C03" modified="2013-07-24" version="1">MTQTPEDHAARFTEVAEEYDDDSSEEYRACAGAVIEGAAPEPDHTVLDLGAGTGAIGLALADAAERVVLRDLSEGMLDQARQKVADRGLDNVEIGEGSFREPNYDGPADVIVSNFALHHLSDAEKREAIEIWAEYEPERIVLGDVMFFEEPDPSVPFYSPEVDDPATVGTLVEAFTDVGYAVVDVQRIHDQVGVIVTHRIGEGDVVPGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5W4</accession>
    <name>R4W5W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00365"/>
    <dbReference type="EnsemblBacteria" id="AGN00028">
        <property type="protein sequence ID" value="AGN00028"/>
        <property type="gene ID" value="L593_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.73"/>
    <dbReference type="eggNOG" id="arCOG08142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208227_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="49" mass="5804" checksum="5DA09723D57E794E" modified="2013-07-24" version="1">MTHTLEIDDDLWERIHDHCEEDESPEEFVAELVSMYEVEGAFLQEGYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W603</accession>
    <name>R4W603_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10460"/>
    <dbReference type="EnsemblBacteria" id="AGN02037">
        <property type="protein sequence ID" value="AGN02037"/>
        <property type="gene ID" value="L593_10460"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10460"/>
    <dbReference type="eggNOG" id="arCOG05166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682775_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="16551" checksum="0A8D0966A8997DD8" modified="2013-07-24" version="1">MSCSSRREDSVHAGESGIVRSWVAGSVIADQRGQTEPIAALVALLAIAIGLGLYAGVAADQSPSRDGTNAEATMQRVEAAILEDGVFSDHGDRSVLPERFGRPGETVRIEITDADGFVWTLGPRAPPGAASASRPITLDWGRNRIPAQLTVWVWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B5</accession>
    <name>R4W6B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445172.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01625"/>
    <dbReference type="EnsemblBacteria" id="AGN00278">
        <property type="protein sequence ID" value="AGN00278"/>
        <property type="gene ID" value="L593_01625"/>
    </dbReference>
    <dbReference type="GeneID" id="16179885"/>
    <dbReference type="KEGG" id="sali:L593_01625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.330"/>
    <dbReference type="eggNOG" id="arCOG00213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_1_0_2"/>
    <dbReference type="OrthoDB" id="40323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="35361" checksum="A1A2FC7D9A3D1312" modified="2013-07-24" version="1">MPRGTSSDRRTVTRRDALAAIAGVGGAALSGCVEFRSAQASGSGLSGSITIRGSSTVYPLMDLMAQRFAGNNDAVSINIAPTGSGAGFADHFCTGNADFNNASRAIRDPEVEQCSSNGVEFVELKLATDAVTVVVNNDADFVDCLTVEELASIWREDGATRWSDVRSSFPDERIARFGAADTSGTYDYFKTNVLGEDATHTLDYQATEQDNNIISGVQGNRFAIGYLGFSYYYNNPDSVKAIGIDSGDGCTVPSLETAASGAYDILSRPLFTYAAKSSLRHDHVAEFARYVVQQSANRSLVADEVGYVPNSAEQMGVELAELNEAIREVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E9</accession>
    <name>R4W6E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11620"/>
    <dbReference type="EnsemblBacteria" id="AGN02267">
        <property type="protein sequence ID" value="AGN02267"/>
        <property type="gene ID" value="L593_11620"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11620"/>
    <dbReference type="eggNOG" id="arCOG01653">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="37035" checksum="E8EF111BB1FAF6D1" modified="2013-07-24" version="1">MLAVPATVGTGTTARSSEFRRTSFVEPNVGTPKSRAAEIQGMRGRSFALAAGAGIAAIGNRALGRAGGALPPALAGDQDYYRWRGMEVAYAALGDPDDPPVVLLHDVGVVGTSREFAGVAEALAEDHRVYAPDLPGYGRSDRPPLTYSASIYEAFVGDFLAEVPDHDAGRPAVVASGLTASYAALAAPRADVERLVLVTPAADTDGRSVARRALVRSPVLGTAIYNWLTSTAGLRNGAVGDRYYGRPDQEYVEYCWQSAHQPGARFAPASYLSGYLDPTMDLETALADVDADVTLLWGRESTDPSLAEGRALAEATDARLVVVDYAKRLPHLEHPTETLAALELGLVPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G5</accession>
    <name>R4W6G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribodipyrimidine photolyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445262.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02085"/>
    <dbReference type="EnsemblBacteria" id="AGN00368">
        <property type="protein sequence ID" value="AGN00368"/>
        <property type="gene ID" value="L593_02085"/>
    </dbReference>
    <dbReference type="GeneID" id="16180070"/>
    <dbReference type="KEGG" id="sali:L593_02085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.424"/>
    <dbReference type="eggNOG" id="arCOG02839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_2"/>
    <dbReference type="OrthoDB" id="33594at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="511" mass="58310" checksum="12E49D20CB1A2175" modified="2013-07-24" version="1">MTVLVLGDQLTRAVGPLADRTPGDRVLLIESRALGRRLPYHPHKLVLLYSAMRHFRDELGDAGFDVEYRKVDTFEDGLDEHFDEHPGDDLVMMAPANHGAAAHLDDLVTSRGGTLEVVANELFLCFAEEFDDWADPDQTRFRHESFYRFVRRETGYLMDGDDPIGGEWNYDADNRETPPAGYRPPEPPVFEPDTLTREVVDWVDETFTGGYDERPFGTDWADPEPFRWPVTRDASLRALESFVDERLPQFGPYQDAMVADEFAMHHSLLSASLNLGLLHPREVVERAIRAYEADEAPLQSVEGFVRQVIGWREFVCHVYRRRMPALATANQLGADRDLPDLYWTGETEMACLSDVVDGVRTRGYSHHIERLMLLSNFALLYGVEPAQLDRWFRAAYVDAYDWVTTPNVVGMGVFGTDALSTKPYAASANYVDRMSDYCANCPYDESKTTGANACPFNALYWAFLDRNEKRLRDNHRMGLVYSHLDGKSDEELSRIRDRARTIRRRARDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S5</accession>
    <name>R4W6S5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445442.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02985"/>
    <dbReference type="EnsemblBacteria" id="AGN00548">
        <property type="protein sequence ID" value="AGN00548"/>
        <property type="gene ID" value="L593_02985"/>
    </dbReference>
    <dbReference type="GeneID" id="16182729"/>
    <dbReference type="KEGG" id="sali:L593_02985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.605"/>
    <dbReference type="eggNOG" id="arCOG02242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140786_0_0_2"/>
    <dbReference type="OrthoDB" id="96961at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="133" mass="15301" checksum="BC99A42343EC1B4A" modified="2013-07-24" version="1">MPDSMSEQLQQDMECEGLLECFHGLKQLDKDCFQALVAADDPLTVDEIAEGVDRERSTAYRAVQRLLQTGFIQKEQVNYEQGGYYHVYSPTDPQKIADDMQRMLNDWYAKMGQLIQEFESKYDETEATASIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6T0</accession>
    <name>R4W6T0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="1">HPPK</shortName>
            <ecNumber evidence="1">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="1">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="1">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptE</name>
        <name evidence="3" type="ORF">L593_12815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447396.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12815"/>
    <dbReference type="EnsemblBacteria" id="AGN02502">
        <property type="protein sequence ID" value="AGN02502"/>
        <property type="gene ID" value="L593_12815"/>
    </dbReference>
    <dbReference type="GeneID" id="16180197"/>
    <dbReference type="KEGG" id="sali:L593_12815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2630"/>
    <dbReference type="eggNOG" id="arCOG04303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093043_0_0_2"/>
    <dbReference type="OrthoDB" id="105604at2157"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="2">
        <location>
            <begin position="47"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="24186" checksum="EA4BCEB336463121" modified="2013-07-24" version="1">MDYETWEPFYDAILADFGYDRAGDEAARDWLAQRVDRFELDSLRLGGTVAIAGAAPSLEADLAVARGADAVVAASDAGVRLAAAGLVPDLVVTDLDGDPEGTIGLAEDGVPVAVHAHGDNRSALERYVPRFPTERLLGTTQAEPVDPLVNYGGFTDGDRAAFLADAVGADRLIFPGWDFDAAEGPKVEKLSWAGVLLHWLERHRGARFELLDGRRTDIDLSGFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6X1</accession>
    <name>R4W6X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445512.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03335"/>
    <dbReference type="EnsemblBacteria" id="AGN00618">
        <property type="protein sequence ID" value="AGN00618"/>
        <property type="gene ID" value="L593_03335"/>
    </dbReference>
    <dbReference type="GeneID" id="16181771"/>
    <dbReference type="KEGG" id="sali:L593_03335"/>
    <dbReference type="eggNOG" id="arCOG00615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_2"/>
    <dbReference type="OrthoDB" id="25704at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="437" mass="47705" checksum="8D0586BB630DCC43" modified="2013-07-24" version="1">MPTLRDPVELGGLELSNRLYRAPVLECAGTNEDTAERLVAELEPAAAAGAGLVFQGATIVRSEGGCAAPGMTRFADDSFVTGLAPVPDAVHDHGGRIFCQLAHGGLRSMEVWHAEYRSEHPDLTQAAAAVLPWQFRLLDRIGVLDFSPEVLTTAEVEALAADFGRAAARAVDAGYDGIHLAGANMGILQQFLSPFYNRRSDRFADGVRLLEAIHDEIRERAGEDVPIVTKVPSERPAPRIVHRHLTDDDAVAICERLAAIGFDGLVPVRTSVTWDMSIVRGKYPERSWNDEQFQAGYDAAFGSRLQKRLVQALNWLQARRFGSEPGWNADLARRVRERVDVPVLLEGGLREREQIDALLGDACDLAGMARPFYAEPELPARLLSDPDAVAVCEDCNNCTVPQVTGASGICRTPSVLERRGELEREGAYDRSTADEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W707</accession>
    <name>R4W707_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_03610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03610"/>
    <dbReference type="EnsemblBacteria" id="AGN00673">
        <property type="protein sequence ID" value="AGN00673"/>
        <property type="gene ID" value="L593_03610"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03610"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.733"/>
    <dbReference type="eggNOG" id="arCOG02764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="891" mass="93096" checksum="A27EC9E38D229014" modified="2013-07-24" version="1">MQPIDEARSGVSDADACTLCDLPTPEPPITDEEVPGTYCCRGCLEVSRTLDDPASADADAAAEALGAGSEAGGGTSSGDVDRDEDEIDGETAYLSVSGMHCATCEAFLESRATSADGVAAAAASYPTETLKVTYDPEAVERDALPGVVDALGYEASHRELDDDRDDQADVGRLLVGGFFGMMTMLWYVLFLYPVYVGVPADSLLVDLTGSAGTYLLVNVWLMATVVLGYTGYPLFRGAYVSLRAGHPNMDLLVAIAAAAAYTYSSAVALTGGTDVYFDVAIVVVMAVTIGNFYEDRTKRRAAGRLADLTTERVDEARRRIGAERRSNGATASTAETETVGVDALEPGDELVVKPGERVPIDGPIVEGDGILDESLVTGESRPVNKTAGDEAIGGSVLRDGRLVVRVEADAQSTLDRVVEVLWDVQSARPGAQRIADRIAAVFVPLVFVLAAVAGAVHLGLGAGFEGALLIALSVLVVSCPCALGLATPLAVARGVRESLADGVVVTDVSTFEAAHEADVVAFDKTGTLTTAEMQVHEVASSDDVEEATLLSRAAALEQYADHPVAAAIVEAADGPVDTVDQFERVPGSGVGGMIVATPDGGARAATGEPGTTDEATVGIEVLVGRLGLFEERGWSIPDAFADRAESARAAGNVPVLVGWNGRVEGVIVAGDEPRTEWERVVEDLAAERRVVVLTGDDASTERFDEHAGVDEVYAGLPPEGKTEVVRRLQAQETVAMVGDGVNDAPALAAADVAIALDHTALAADAAGAVVTTDDLRAVPRIFERTRATNGRIKQNLGWAFLYNAIALPLAVAGLLNPLFAAVAMASSSLLVVANSSRALVETSSRTLPENDRDGEHAGHDVEWDGKHGERDDSSGELMEPDREPEPEVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W789</accession>
    <name>R4W789_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0391 membrane protein L593_04385</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0391 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04385"/>
    <dbReference type="EnsemblBacteria" id="AGN00828">
        <property type="protein sequence ID" value="AGN00828"/>
        <property type="gene ID" value="L593_04385"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04385"/>
    <dbReference type="eggNOG" id="arCOG08018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187346_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="7864" checksum="2D08DF59F8A9CE60" modified="2013-07-24" version="1">MLPQTTAVTAVSDGLTAATTVPAQFFTGAFLEWAILFFVLAIVAAVLGAGDVAGVSMAIGKWLVIIFVVLAVVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D6</accession>
    <name>R4W7D6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_04820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445807.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04820"/>
    <dbReference type="EnsemblBacteria" id="AGN00913">
        <property type="protein sequence ID" value="AGN00913"/>
        <property type="gene ID" value="L593_04820"/>
    </dbReference>
    <dbReference type="GeneID" id="16181104"/>
    <dbReference type="KEGG" id="sali:L593_04820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.985"/>
    <dbReference type="eggNOG" id="arCOG00253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_1_2"/>
    <dbReference type="OrthoDB" id="47911at2157"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="327"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="46479" checksum="72FD2D2BE57CE2F6" modified="2013-07-24" version="1">MHVSVVGSGYVGSTIAAVFADWGHQVTAVDVDEDIVDAINGGEAPIHEPGLDERVAEHGGDRLRATTDYDEIPATDITFLALPTPSREDGSIDTSIIEAAAEALGEALADVDEHVAIVKSTVVPGTTENVLAPLVKAKAGDRVSVGMNPEFQREGTAVADFLDPDKLVFGTEAGGANGIGEDAEEDRALDALYEVYAPLIEAQDPPIVETGLSEAEFIKYANNAFLAAKVSLINDLGNVAKEFDVDAYEVADAIGLDDRIGERFLRSGVGWGGSCFPKDVKAIIAAAEAKGYDPAVLQAAVDLNDRQPERLLDLLDRHLDVEGKTVAVLGLAFKPGTDDVRNSRAIPVIEGLEARGAEIVAYDPVAVENMREHFPDLTAADSAAAAIEGADAAVVTTDWDEIEALDSAAVGGMATPVIVDGRRAIDPAILDVEGLVYEGLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U8</accession>
    <name>R4W7U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_00695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00695"/>
    <dbReference type="EnsemblBacteria" id="AGN00094">
        <property type="protein sequence ID" value="AGN00094"/>
        <property type="gene ID" value="L593_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.141"/>
    <dbReference type="eggNOG" id="arCOG03072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="14317" checksum="FC7F08A15247D21C" modified="2013-07-24" version="1">MTLETIPHVPLLLEVLANRYAYVLFALLLGIGLYMMVSSRNLVKKVIGLNLFQTALFLFFIASAYVAGGQAPIVEKGSEATYVSPLPHVIVLTAIVVGIALTAVALALLVRIYTEYGTLEEDVLQEVRHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W4</accession>
    <name>R4W7W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445018.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00845"/>
    <dbReference type="EnsemblBacteria" id="AGN00124">
        <property type="protein sequence ID" value="AGN00124"/>
        <property type="gene ID" value="L593_00845"/>
    </dbReference>
    <dbReference type="GeneID" id="16182192"/>
    <dbReference type="KEGG" id="sali:L593_00845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.173"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_2"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="10109" checksum="4B897674AC719707" modified="2013-07-24" version="1">MSVTLKDFYADWCGPCKTQDPILDELSEDWGDRFAVEKVNVDEEQEIANEYQVRSLPTLIVENEDGVVERFVGVTQREDLEDALEQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z4</accession>
    <name>R4W7Z4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446237.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06980"/>
    <dbReference type="EnsemblBacteria" id="AGN01343">
        <property type="protein sequence ID" value="AGN01343"/>
        <property type="gene ID" value="L593_06980"/>
    </dbReference>
    <dbReference type="GeneID" id="16181953"/>
    <dbReference type="KEGG" id="sali:L593_06980"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1426"/>
    <dbReference type="eggNOG" id="arCOG01960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116143_0_0_2"/>
    <dbReference type="OrthoDB" id="100060at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="165" mass="17764" checksum="C3F88EF0B604040D" modified="2013-07-24" version="1">MDVIESDLPGVGKKHEVELGDGQVLVIVTHNTGQRELYLKPDADADSEKLLELSDRMARMVGTILEGAYFQPVESEHVETMLTEGTLLEWYAVDDSSPLVGETLASAQVGRETGVTVVAIQRGEDVLSAPDSGTELQAGDTLVVVGDRESCNAFETLLTGEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W827</accession>
    <name>R4W827_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Shikimate kinase</fullName>
            <shortName evidence="8">SK</shortName>
            <ecNumber evidence="5 8">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroK</name>
        <name evidence="10" type="ORF">L593_01480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445143.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01480"/>
    <dbReference type="EnsemblBacteria" id="AGN00249">
        <property type="protein sequence ID" value="AGN00249"/>
        <property type="gene ID" value="L593_01480"/>
    </dbReference>
    <dbReference type="GeneID" id="16179823"/>
    <dbReference type="KEGG" id="sali:L593_01480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.301"/>
    <dbReference type="eggNOG" id="arCOG01025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073768_0_0_2"/>
    <dbReference type="OrthoDB" id="98200at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="30205" checksum="0F441A41DE2688FB" modified="2013-07-24" version="1">MDGRARAPGAGTVLNALATGRGSAFAIEAYTTASVSLDTELEVVTGEIAGAPDADTALIERCVELVVERFGDGEGGAVRTESDVPMAAGLKSSSAAANATVLATLDALGVADEDPTLVETGAIDRADACRIGVQAARDVGVTVTGAFDDASASMLGGVTVTDNTEDDLLAREERDWDVLVYTPDEQAFTADADVDRCERIAATADLVAEHALEGDFARAMTVNGFAFSAALEFPTEPMIEALPHAEGVSLSGTGPSVVAVGERTELEAVEAIWQERPGTTRLTTTQIEGATIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W829</accession>
    <name>R4W829_9EURY</name>
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        <submittedName>
            <fullName evidence="3">MaoC domain protein dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445148.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01505"/>
    <dbReference type="EnsemblBacteria" id="AGN00254">
        <property type="protein sequence ID" value="AGN00254"/>
        <property type="gene ID" value="L593_01505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182023"/>
    <dbReference type="KEGG" id="sali:L593_01505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.306"/>
    <dbReference type="eggNOG" id="arCOG00774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_0_1_2"/>
    <dbReference type="OrthoDB" id="83488at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="19314" checksum="B8AE60C2D8361619" modified="2013-07-24" version="1">MPGRYFEEFDVGETIRHDKRRTISESDNQRFCDMTMNQQPLHLDADFAADTQFGDRLVNGLYTLSLAVGLTIPETTDGTIVANLSYDDVEHPAPVFHGDTIRAQSTVTDARETSDGERGIVTMHVEAFVVDPVRDEATADAKRPVRDPNDDGEVLVCSFERTVLSQKRPDDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W846</accession>
    <name>R4W846_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01765"/>
    <dbReference type="EnsemblBacteria" id="AGN00304">
        <property type="protein sequence ID" value="AGN00304"/>
        <property type="gene ID" value="L593_01765"/>
    </dbReference>
    <dbReference type="GeneID" id="16182067"/>
    <dbReference type="KEGG" id="sali:L593_01765"/>
    <dbReference type="eggNOG" id="arCOG04757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152338_0_0_2"/>
    <dbReference type="OrthoDB" id="111819at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046243">
        <property type="entry name" value="DUF6276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19792">
        <property type="entry name" value="DUF6276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13232" checksum="C5C2BCF50E97C7E5" modified="2013-07-24" version="1">MSCTRCDEPTVDLVVPESLQPYAQGATVSVCTNCLTVEAGEGGSGHDLDAISEDLPEGDAGVGTLLLVDLLDSLATNRADIEGLIDEIEADGADPMLALDRLANDPGLDPAVDIDRRRTQLEQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W860</accession>
    <name>R4W860_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0179 protein L593_07840</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0179 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446407.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07840"/>
    <dbReference type="EnsemblBacteria" id="AGN01513">
        <property type="protein sequence ID" value="AGN01513"/>
        <property type="gene ID" value="L593_07840"/>
    </dbReference>
    <dbReference type="GeneID" id="16182236"/>
    <dbReference type="KEGG" id="sali:L593_07840"/>
    <dbReference type="eggNOG" id="arCOG04477">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121764_0_0_2"/>
    <dbReference type="OrthoDB" id="108341at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00498">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005369">
        <property type="entry name" value="UPF0179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40699">
        <property type="entry name" value="PTHR40699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03684">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006595">
        <property type="entry name" value="UCP006595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="149" mass="16184" checksum="93AC6CA3B2FCDAE1" modified="2013-07-24" version="1">MSQLTLLGTRLAEEGQEFVYHGEASGCEGCPYRSQCLNLTEGVKYEVTEVRENTQKLDCAVHDDGVRAVDVEPASVTANVPSTGAYAGSKTALAGPCPLTSCPSHELCVPDGADFDDSYRIEEVLGEPPHEHCHLDRELTMVEFAPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W861</accession>
    <name>R4W861_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445243.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01990"/>
    <dbReference type="EnsemblBacteria" id="AGN00349">
        <property type="protein sequence ID" value="AGN00349"/>
        <property type="gene ID" value="L593_01990"/>
    </dbReference>
    <dbReference type="GeneID" id="16180017"/>
    <dbReference type="KEGG" id="sali:L593_01990"/>
    <dbReference type="eggNOG" id="arCOG09230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870826_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="13658" checksum="57207EA619842FFE" modified="2013-07-24" version="1">MSRTTTSRRRFGAVIASAITVGLAGCGGGGDDNETEEDGVTDDETATGDDTTGDTTGDEDTDGEPVTGDDENETDDDGNVTDGAGNETDGAGNETDGEGNVTEDGNMTDEDGNVTGDDGNATDGENTTMDGNETDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W887</accession>
    <name>R4W887_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445318.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02365"/>
    <dbReference type="EnsemblBacteria" id="AGN00424">
        <property type="protein sequence ID" value="AGN00424"/>
        <property type="gene ID" value="L593_02365"/>
    </dbReference>
    <dbReference type="GeneID" id="16180182"/>
    <dbReference type="KEGG" id="sali:L593_02365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.480"/>
    <dbReference type="eggNOG" id="arCOG01684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090889_0_0_2"/>
    <dbReference type="OrthoDB" id="87825at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="24867" checksum="6658A7232369B15E" modified="2013-07-24" version="1">MDSAALLDLLGNENRRRILRLLARKPCYVTEISEYLGVSPKAVIDHLRKLEDAGLVESHMDERRRKYFHISRNLRLEVNVSPYEFGAKSAYPASRSFDITAWRHLTVDVSLEENGHDPGELASELKELHDLENELSMAQRWVQGRITETVEDLTDAVDGDADGDGRLHADVLVTLADGKQDTTELSEAVDAPPTVVEESLVALAEQGIVDRDEDGWYLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C1</accession>
    <name>R4W8C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02815"/>
    <dbReference type="EnsemblBacteria" id="AGN00514">
        <property type="protein sequence ID" value="AGN00514"/>
        <property type="gene ID" value="L593_02815"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.569"/>
    <dbReference type="eggNOG" id="ENOG502N5GU">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259149_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="21813" checksum="EE0D532AA56268D8" modified="2013-07-24" version="1">MHCSADLTAEREAADADDDGVWDSAEIPASGWGEEAADADQSLEAGAGGAAESGARGAAESGTGDAAGSGTDGTATSVDQHDGLLDPQGIVDDALTVVVGILGGIVVGLVATVVLLILTGSGWALLFGFVGWLGATAYLVRRRTVQGAISKSAYAVAAVFLLIPLVVASPVIHVEGGVEDRVEGFLVLLVLVAFPAGVAAVVGFVAARFVPEEADGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E1</accession>
    <name>R4W8E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445468.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00574">
        <property type="protein sequence ID" value="AGN00574"/>
        <property type="gene ID" value="L593_03115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180438"/>
    <dbReference type="KEGG" id="sali:L593_03115"/>
    <dbReference type="eggNOG" id="arCOG04682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072981_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="47"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="35036" checksum="B059E633F999EA97" modified="2013-07-24" version="1">MSDPVERAVGSALPSCTVATIEPQTVRPGNHTARVDFENADPVYVKTATDTSRRLEREIAATRYAAAHSGVETPPIVAADAGGEPPYLATEPLPGTIFNDAWRDDGDRGRLLRLVGRAIAGVHEARFDRSGVVEGGDRTGLDLVGEDWADVLCRTVEWRADDWFPDRFDDLPERLVSVIREFDPAVAGTPTLLHCDPSRINVHFEPLGMLDWERAMVGDPAFGLVEAAFHHLEQPDVSEEERRELEAALHEGYRERAGDLPTGLERNRPLYRAISHMLVPQAFEDWSSDVDRPNDELAANVREAFTDRLERARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E4</accession>
    <name>R4W8E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445483.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03190"/>
    <dbReference type="EnsemblBacteria" id="AGN00589">
        <property type="protein sequence ID" value="AGN00589"/>
        <property type="gene ID" value="L593_03190"/>
    </dbReference>
    <dbReference type="GeneID" id="16180455"/>
    <dbReference type="KEGG" id="sali:L593_03190"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.645"/>
    <dbReference type="eggNOG" id="arCOG00985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OrthoDB" id="85279at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="164" mass="17515" checksum="A3C6731DEB92A14C" modified="2013-07-24" version="1">MEISSRHHLRSDEVSAIEDAMADQLGVEVDGDSYELVELADSEFDLVLVDGEPDVLYVEDEAGEAEPFLTVRGANRFEPETHVVTVDAGAVSFVSDGADVMRPGIVEADESIEEGDLVAIAEESHGKVLGIGRAMVGGEDMVGDSGKVVKSVHHVGDDLYQFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8E7</accession>
    <name>R4W8E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445493.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03240"/>
    <dbReference type="EnsemblBacteria" id="AGN00599">
        <property type="protein sequence ID" value="AGN00599"/>
        <property type="gene ID" value="L593_03240"/>
    </dbReference>
    <dbReference type="GeneID" id="16180312"/>
    <dbReference type="KEGG" id="sali:L593_03240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.655"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_11_1_2"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="134" mass="14714" checksum="9A45861081C1113C" modified="2013-07-24" version="1">MSDTEDSEVEAIREQKRQELVEAATGSDAPDEPIHVEDEAHFEELLETHDVVLVDFYADWCGPCDMLEPIVEDVAAESDAAVAKLDIDALQRVAQSYGVRSVPTLIVFADGEQAEQMVGVQQKGAIMNLLERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F5</accession>
    <name>R4W8F5_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446612.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08865"/>
    <dbReference type="EnsemblBacteria" id="AGN01718">
        <property type="protein sequence ID" value="AGN01718"/>
        <property type="gene ID" value="L593_08865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182680"/>
    <dbReference type="KEGG" id="sali:L593_08865"/>
    <dbReference type="eggNOG" id="arCOG09160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757836_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="365" mass="37302" checksum="5FFE6F3C2328B796" modified="2013-07-24" version="1">MSGNGSETDATDAQPSERRDEAERGESADSGGQVEHEGPADGGDQADGEGRADDGVRADRGQPDAAEPHDSLLAALHVTRHLRVGLAVGIGLAAFLYLPRLPAFDRSIQGAEGFYLGLAFVLAATTAGLVTAALSIKTFLEPVLDRPAWLRRGGMAAMLGGLGWASTPLLAAGADAGSIDATLWRNVTSLAALALLVGTIGLHSAVKQAVATVSERIRRIERAAYWIALIGLLIAAANATGDAAPVRVAGSEDVATPFLIGALLAAVAVIPFAATAELSGRLPRWRIRSLQVGGLIGAVGTAWLVSLGGWDWLAQFDAPAALGLAVTVVPVGLGWAIAGLGLWTSARQREAAASPGEPGDGLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J1</accession>
    <name>R4W8J1_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09440"/>
    <dbReference type="EnsemblBacteria" id="AGN01833">
        <property type="protein sequence ID" value="AGN01833"/>
        <property type="gene ID" value="L593_09440"/>
    </dbReference>
    <dbReference type="GeneID" id="16182711"/>
    <dbReference type="KEGG" id="sali:L593_09440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1943"/>
    <dbReference type="eggNOG" id="arCOG01054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_2"/>
    <dbReference type="OrthoDB" id="46312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
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        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="2">
        <location>
            <begin position="43"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="43032" checksum="403F2D9DB95BCF9B" modified="2013-07-24" version="1">MSILQPTPEDRRRVIDESGEVVEGAELPDLTDDELVEMYEHLRLARHFDERSVSLQRQGRMGTYPPLSGQEGAQVGSAFALDDEDWIFPSYREHGTLEIRDVPLERILLYWMGSERGSKMPEGSNVFTPAVPIATQIPHATGAAWASKLQDEEDRAFLCYFGDGATSEGDFHEGLNFAGVFDTPNVFFCNNNQWAISVPRERQTASATLAQKATAYGFEGVQVDGMDPLAVYQETRRAVKKAKDPDSVEPRGDAESIGDARRPTLIEAVQYRYGAHTTADDPSVYRDEEEVEKWRELDPIPRMESFLREHGLLDDERDDAIQSRIEERVADAIETAESVERPDPEEMFADVYADMPKRLQEQLDYLERLRAEHGDETLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N8</accession>
    <name>R4W8N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446862.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01968">
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        <property type="gene ID" value="L593_10115"/>
    </dbReference>
    <dbReference type="GeneID" id="16179878"/>
    <dbReference type="KEGG" id="sali:L593_10115"/>
    <dbReference type="HOGENOM" id="CLU_1782565_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15405" checksum="431D4D0D4F4F55FF" modified="2013-07-24" version="1">MRGTNGDWSRRRVLIAFGGAGVTGIAGCSVLKDDDGSSDSDSPPGTEFGIEFDPEASNYTITYEGNQAFTEDNTGLLAIDHVTETGTADRMVWFGGPEFGPVEPGESTLWGYDTERVTALEVVWAPPESAGSGRAPDVLTRRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R5</accession>
    <name>R4W8R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445753.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04540"/>
    <dbReference type="EnsemblBacteria" id="AGN00859">
        <property type="protein sequence ID" value="AGN00859"/>
        <property type="gene ID" value="L593_04540"/>
    </dbReference>
    <dbReference type="GeneID" id="16180987"/>
    <dbReference type="KEGG" id="sali:L593_04540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.926"/>
    <dbReference type="eggNOG" id="arCOG02278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010057_3_0_2"/>
    <dbReference type="OrthoDB" id="56183at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="519" mass="55785" checksum="08211C1A96B9ABC1" modified="2013-07-24" version="1">MGDPLEHAPIGVVALDANDCVRSLNPRACELLSVTPDDAEGEPLDDVFPRSVDEGVREALAAEPATEGVDRDPRDRPIEEYYPALEHWLAVTVVPDGEGGTVLYVEETTDEHRAERREAELVDDLDRLGLTNELVADVLDALVDASTRSEIATRICDRLGTADRFDFAWVGEREIGSDGIAIRAADGTTDQTLDAIETLLAGDEAIPERRVIDSGSVEVVQPLGADESVPEPIRRAAFADGLQSLLAIPLRYGSSVYGVVGVYASDRAAFSDREASSFATVGEMAGFAINATRQRALLESSTVVELRFDLTGVASPFVESAVEADAALSLEGTVHRGEDLLCYLDVASAAPSTVASALQDREAVSATRIVSTEDAAGSIEAAIAPSTPIGVLDSQGLTLESATFEPGEHRVTVEVPPEEDVRRIADAFVRAFDASVEAKLERQRTDPTAAEVGSALHDRLTEYQERALRTALFAEYFESPRGSTAEEVAEALDITAPTLLYHLRAGQRKLLEEHFDADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V8</accession>
    <name>R4W8V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445868.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05125"/>
    <dbReference type="EnsemblBacteria" id="AGN00974">
        <property type="protein sequence ID" value="AGN00974"/>
        <property type="gene ID" value="L593_05125"/>
    </dbReference>
    <dbReference type="GeneID" id="16181164"/>
    <dbReference type="KEGG" id="sali:L593_05125"/>
    <dbReference type="eggNOG" id="arCOG09204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190391_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8813" checksum="B1E5D4547BA5F5A6" modified="2013-07-24" version="1">MYTTRDLLAIVLAAVLGLALVVAPGAVLRLQWFTFDPTSGRRGEWGNDEPRQFDAKWLWLLRGIGVVVLAIGAAIVAIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X1</accession>
    <name>R4W8X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447052.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11065"/>
    <dbReference type="EnsemblBacteria" id="AGN02158">
        <property type="protein sequence ID" value="AGN02158"/>
        <property type="gene ID" value="L593_11065"/>
    </dbReference>
    <dbReference type="GeneID" id="16182035"/>
    <dbReference type="KEGG" id="sali:L593_11065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2283"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OrthoDB" id="34141at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="454" mass="48762" checksum="0F0409D968FFA85F" modified="2013-07-24" version="1">MDRASAEPSVRSVPGARASRWVEAHHEHAAPSTHVYEFVWDHTAPAAGPFCTDVDGNVLLDFTSHVGAAPLGYENRRIREKLDAFDVPDPAKIAGQDFYVAGGEGGPAEPEFPGPTQLQDRLADRSSDYGLDTVFLSNSGAEAVENAIKICYDDTGGRRGITFEGAFHGRTLGALSLNRSKQVHRHTFPDVGGIVDAPYCDDAGTDPGTCDCGFFVDGGDSSVLRRKLDPNAGHLPADEVAYIIVEPIQGEGGYRIPSDPFLEELSDLAALHDIPIVVDEIQSGIGRTGDFWAVDHGPIEPDVIASAKALRVGATIADSDTFPETEGRLSSTWGAGDVLASLQGVLTLDVIEEENLLANATARGEQFLDLLADADLPGAVDVRGRGLMLAVEFDEKERRDAIVRECFERGLLLLGCGYSTIRFLPPLDVREREVSMGVDTFADAVQAVRGVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W902</accession>
    <name>R4W902_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447117.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02223">
        <property type="protein sequence ID" value="AGN02223"/>
        <property type="gene ID" value="L593_11390"/>
    </dbReference>
    <dbReference type="GeneID" id="16181023"/>
    <dbReference type="KEGG" id="sali:L593_11390"/>
    <dbReference type="eggNOG" id="arCOG06449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2875246_0_0_2"/>
    <dbReference type="OrthoDB" id="118559at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="63" mass="6629" checksum="83126CD7E2E17F29" modified="2013-07-24" version="1">MSQPDDPSEGRCQRCGTSVSTRFRKVFGGNDATVHGCVECMTLSELCEGQAAAHDEAGAPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W911</accession>
    <name>R4W911_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446008.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05825"/>
    <dbReference type="EnsemblBacteria" id="AGN01114">
        <property type="protein sequence ID" value="AGN01114"/>
        <property type="gene ID" value="L593_05825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181526"/>
    <dbReference type="KEGG" id="sali:L593_05825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1193"/>
    <dbReference type="eggNOG" id="arCOG09272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490400_0_0_2"/>
    <dbReference type="OrthoDB" id="130395at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8993" checksum="3F8015854BFD24C7" modified="2013-07-24" version="1">MGSRLATAAVGVVVSLLLSAALWYYFDSFVFFLFVPFVPFLFRRSAGSGPEPPVSECPQCGFRTTDDSFEYCPRDGTRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W914</accession>
    <name>R4W914_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446013.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05850"/>
    <dbReference type="EnsemblBacteria" id="AGN01119">
        <property type="protein sequence ID" value="AGN01119"/>
        <property type="gene ID" value="L593_05850"/>
    </dbReference>
    <dbReference type="GeneID" id="16181516"/>
    <dbReference type="KEGG" id="sali:L593_05850"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="340" mass="38076" checksum="A5C9692CD7DC4D41" modified="2013-07-24" version="1">MNWYVKRTGQALFTLWSVVTLAFILVQQMPGNMVQRYVDQVLRNRPNANPEQVRQSIENQLVYDPDAPLWESYLTYMENLIIEQNLGYSIEAGENLNSVMADAVPWTLFVMSIATFGLFGFSLMLGAIMAYKEGSIFDLSNTVLGIVTTSVPYYVAGILLIIYVGYGDGLILDWFPVRNRLPADVDPGFTLAFVVGAFQHAILPALSYILTAYGLLALSMRGNSIQTLGEDYVRVAELRGLPSRRIALRYVGRNAVLPLYTSLLISIGFMLGASVILEQIFQYQGVGFWMFRGIENRDIPLMMSVFLLITITVVIATFFADLSYGWLDPRIKSGDEGEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W947</accession>
    <name>R4W947_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_12100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447257.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12100"/>
    <dbReference type="EnsemblBacteria" id="AGN02363">
        <property type="protein sequence ID" value="AGN02363"/>
        <property type="gene ID" value="L593_12100"/>
    </dbReference>
    <dbReference type="GeneID" id="16181655"/>
    <dbReference type="KEGG" id="sali:L593_12100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2490"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="41087at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="481" mass="52826" checksum="B4B0A54E747C765B" modified="2013-07-24" version="1">MSRANEEPILRAENLTKHFDTSEGFIDDLLGRSQMVKAVDGVDLELYEGETLGVVGESGCGKTTLGRTLLRLLEPTDGSVTYRQRVDDATAGDGTRSTEREEIDLMDLSSRKLRSLRTDLQYIFQDPFSSLNPRLTVGDIIGEPLDIHDIASGQERNDRIKVLLDTVGLNPSHVNRYPHEFSGGQRQRIGIARALAVDPEIIVCDEPVSALDVSVQAQILNLLEDLQEEFGLSYVFIAHDLSVVEHISDRIAVMYLGEFAEVGTTEEIFEPPYHPYAEALLSAIPEPDPGWEGDRILLPGTVPSPINPPSGCRFHSRCPRVIQPESVDLEQADWRSLMDFKVRLREAEGLESVTAIEGAEETSAVDTSSEITAEGHVDPETASRAELDTLVRDEFELPATLADSRAESVLSDTIGALHEGDVRGASEHIDEELPSPCETTTPEQIHVGGTHQIACLRYDDTHEGTRPVWEGQSPGDATADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H9</accession>
    <name>R4W9H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447567.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13670"/>
    <dbReference type="EnsemblBacteria" id="AGN02673">
        <property type="protein sequence ID" value="AGN02673"/>
        <property type="gene ID" value="L593_13670"/>
    </dbReference>
    <dbReference type="GeneID" id="16180770"/>
    <dbReference type="KEGG" id="sali:L593_13670"/>
    <dbReference type="eggNOG" id="ENOG502N604">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044510_0_0_2"/>
    <dbReference type="OrthoDB" id="97409at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13243" checksum="6B720572E93F4D61" modified="2013-07-24" version="1">MGTNTAPIEGYETAEVEREDDGDDVPEIDLAEDGPVAGTVVNIRSGEDDRGPWHLLTVLDDDQGLVKVWAKWDVKQHVNSGRIREGTDVCLYVDDSEERTLPDSDESQHPHKAAFPEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J4</accession>
    <name>R4W9J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_08170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446473.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08170"/>
    <dbReference type="EnsemblBacteria" id="AGN01579">
        <property type="protein sequence ID" value="AGN01579"/>
        <property type="gene ID" value="L593_08170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182615"/>
    <dbReference type="KEGG" id="sali:L593_08170"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821163_0_0_2"/>
    <dbReference type="OrthoDB" id="102655at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="37165" checksum="C96CD15CF04F7CD4" modified="2013-07-24" version="1">MSRLATHYEALRERFGNGRIDRDSAPHWLGPLRRRFVAADGASVLESALDRPTLATMGVGMTGPPHLGTVGQLLTAIELQEAGLDVQFVLADLEPYHGGGDIERIGRLAERYRAFALDLGFDPERGTLRTQSEATNAMATGHRIARYYPTEQGDAGADRPRTDWERAVDAAYEAAPGDDAPAPTSAAADAHSSVLHGADFLHPLVEGNYEQLLLVFGADESDLLPWARSFRDDAGISGRIGGLFTRMVPGFEGVPKQSKSTDAGVSLAEAPAAIHERIAAVRDSADPTDSTVFQSMCLASRYDAERLDALAERYEAGGEAWEAARREYAEYVAGLAERWHATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N2</accession>
    <name>R4W9N2_9EURY</name>
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        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446548.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08545"/>
    <dbReference type="EnsemblBacteria" id="AGN01654">
        <property type="protein sequence ID" value="AGN01654"/>
        <property type="gene ID" value="L593_08545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180539"/>
    <dbReference type="KEGG" id="sali:L593_08545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1750"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_2"/>
    <dbReference type="OrthoDB" id="89591at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="191" mass="20488" checksum="3DB838A8A2D488F3" modified="2013-07-24" version="1">MDAPHVVGIPGSLREGSYTRTATRRALDGVERAGGTAELVDLRDYDLPIFDADHDAAADAPDLATTVREADAVLLGTPMYHGSYSSPLKTALDYCGFDEFEDETVGLLAVSGGGFPTPALEHLRSVCRALNAWVIPHQVAIPKAYAAIDDGEIVDDDLDERTLVLGRRAVQYADIEPDPDSFESDQNVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R2</accession>
    <name>R4W9R2_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Putative sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447817.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02923">
        <property type="protein sequence ID" value="AGN02923"/>
        <property type="gene ID" value="L593_14945"/>
    </dbReference>
    <dbReference type="GeneID" id="16181593"/>
    <dbReference type="KEGG" id="sali:L593_14945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3052"/>
    <dbReference type="eggNOG" id="arCOG02909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069298_0_0_2"/>
    <dbReference type="OrthoDB" id="64764at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016954">
        <property type="entry name" value="Uncharacterised_Vng0742h"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030471">
        <property type="entry name" value="STR_Vng0742h_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DICT" evidence="2">
        <location>
            <begin position="118"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="257" mass="28362" checksum="0017CB43C2824207" modified="2013-07-24" version="1">MSLDDVIASVERSERTLTVFNPREEVRDGDTEAGGSGATTRADSGFVDELSELLVDRNVTVQSTTTTSGRPVNFSVLEMDGVVLATFDVDELHERLAEPSSSVTGLGVGTDDSADVLRHLQEATFTSFDRERMLQATREIEDRAFRIGEGDLRAGFQTVDRLLIEQERYVELGKRGLDVTVYATPDRDVDGLSPVTVRATDSAEIATHWFVAFDGGGEPSQECALLAEERSDGFYGFWTYDPDVVDWILTHLVDAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S4</accession>
    <name>R4W9S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01729">
        <property type="protein sequence ID" value="AGN01729"/>
        <property type="gene ID" value="L593_08920"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08920"/>
    <dbReference type="eggNOG" id="arCOG11457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="15899" checksum="77B0572D856DDB05" modified="2013-07-24" version="1">MLGASLTLLTFGIGYDLVVGTTFADFAMVVTGLFIGWVAFFYCLGHLSGWDRFPGGRSEEAPGEGSTREGATEEEEPGSVAVRSEETRAEDSRDEAIRGQGTRDEAARGDEPPSEEARSEASRTEASRSEERQDAEPRSDATRDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9T6</accession>
    <name>R4W9T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_09120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446663.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09120"/>
    <dbReference type="EnsemblBacteria" id="AGN01769">
        <property type="protein sequence ID" value="AGN01769"/>
        <property type="gene ID" value="L593_09120"/>
    </dbReference>
    <dbReference type="GeneID" id="16182624"/>
    <dbReference type="KEGG" id="sali:L593_09120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1870"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="553" mass="58146" checksum="09B8251D37B78C07" modified="2013-07-24" version="1">MQQGQPMIVMSEDSQRVKDEDAQDYNIAAAQAVAEAVRSTLGPKGMDKMLVSSMGDVTVTNDGVTILQEMDIDNPTAEMIVEVAETQEDEAGDGTTTAVAIAGELLKNAEDLLEQDIHPTAIIKGFHLASEQARAEIDDVALEVDPGDEDLLRSVAETSMTGKGAELNKEHLADLIVRAVQAVTIEADDGSNVVDLEFLKTETQTGSAADESALLEGAIVDKDPVHDNMPTEVEDANILLLDSPIEVEETDVDTSVNVSDPDKLQQFLDREEEQLKEMVDQIADTGADVVLCQKGIDDLAQHYLAKEGILAVRRVKKSDVEFLREVLGASIVSDLDDATADALGHGDVVRDSEDEAFHVTGSGESHGVTLLLRGSTDHVVDELERGVSDALEVVAQTVSDGRVLAGGGATEVEVARRLRDYADSVSGREQLAVEAFADALELVPRVLAENSGLDPIDTLVDLRAAHDDGDVRAGLNVFSGDVVDTFDAGVAEPAHAKQQAVSAATESANLVLKIDDIISAGDLSTEGEEDEGAGGPGGGMGGMGGMGGMGGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z5</accession>
    <name>R4W9Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446958.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10595"/>
    <dbReference type="EnsemblBacteria" id="AGN02064">
        <property type="protein sequence ID" value="AGN02064"/>
        <property type="gene ID" value="L593_10595"/>
    </dbReference>
    <dbReference type="GeneID" id="16180046"/>
    <dbReference type="KEGG" id="sali:L593_10595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2184"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076274_2_0_2"/>
    <dbReference type="OrthoDB" id="81550at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="25459" checksum="65F9DA5B4F44B1C2" modified="2013-07-24" version="1">MTVIAHLRIPADSFELGRILELESGTTAELENMVPLGERAVPFFSVSEEVRADFEANVQDHPSVDRIVEVTRHEEERLYSLDWNVGRDVFFQGIVELDGQLLSAAGTAGTWEFEIRFPTHETLSEFQDYCASAHIDLEVGRIYNPTRPGTGIWYGLTAAQRDTLMRAVHGGYYSIPREMSTQDLAEQLGISDQAVTERLRRAIVGLVQNTLIAMEEDSEERFVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA09</accession>
    <name>R4WA09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pilin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447028.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10945"/>
    <dbReference type="EnsemblBacteria" id="AGN02134">
        <property type="protein sequence ID" value="AGN02134"/>
        <property type="gene ID" value="L593_10945"/>
    </dbReference>
    <dbReference type="GeneID" id="16181957"/>
    <dbReference type="KEGG" id="sali:L593_10945"/>
    <dbReference type="eggNOG" id="arCOG02416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116126_0_0_2"/>
    <dbReference type="OrthoDB" id="110213at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="14671" checksum="00C49467842702C3" modified="2013-07-24" version="1">MRLRELFTDDDAVSPVIGVILMVAITVILAAVIGAFVLGFGGGGPSAPSVQWEATDTGTPNGEVTFSHGGGDTISEPGDVLGMNFDGSGSLNTTDPSYGGGSPMDVGDSWTVGYSSTSSGDQIILTWSSPDGDSTQELKTHTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA21</accession>
    <name>R4WA21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447088.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02194">
        <property type="protein sequence ID" value="AGN02194"/>
        <property type="gene ID" value="L593_11245"/>
    </dbReference>
    <dbReference type="GeneID" id="16181393"/>
    <dbReference type="KEGG" id="sali:L593_11245"/>
    <dbReference type="HOGENOM" id="CLU_665017_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="413" mass="46179" checksum="4369F153A34C9127" modified="2013-07-24" version="1">MVDRRRRRLLAATGSVGLFGLAGCSSGGDSDDDPDGTPAGDTQSGDSGDQTDDTSGTNGADDSSGTDEYAPDIPDEYILHLVPDRNEELRQQVPDDQLERYREEFGTDLIEDSNVFADDPGEEWRQMEVDLLALEWWHDNDYLNIQHEEGSQFVESIGTDSPEESIECEAKNTPPLVRYPNSEGESNTYGHFDYQEFTQTESVGEALDWLQKYLFNWQMLHDDPGPISTEDELYAAALQECLDAHTDIESHCWALDLPEASASTHGNGLIYDATNNELRVMETINGPETQTAGSTDEQYHPLGEDSNYLDPSHEAYDSWWHPLRFADDHQQDTVEGHESLDFETRKKSVASTLMDIATGADEDVEIGSLTDVGITTQYLVDFTGKLADWNQNEEYDGELFEEIKKTSPKSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA75</accession>
    <name>R4WA75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02464">
        <property type="protein sequence ID" value="AGN02464"/>
        <property type="gene ID" value="L593_12625"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2591"/>
    <dbReference type="HOGENOM" id="CLU_1860781_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="14046" checksum="9B4A391C42EB8959" modified="2013-07-24" version="1">MILILVGLLLLLSPAVLLLVTLAFLSVIGEVVLGRLTAVELIELYLIDFFVVGGILFVMIALLRRLIERRLGIALDSLAEGDGRPDDDDAAEDDAAEDDADGSDDADGSGDIDGSGEAGGSVVTGGSGETDGNGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB5</accession>
    <name>R4WAB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13625"/>
    <dbReference type="EnsemblBacteria" id="AGN02664">
        <property type="protein sequence ID" value="AGN02664"/>
        <property type="gene ID" value="L593_13625"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13625"/>
    <dbReference type="eggNOG" id="arCOG02917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="117" mass="13010" checksum="23EB176A5DD23B98" modified="2013-07-24" version="1">MGFLEEDYDVGMSPTDFEPRDLTVDVGTTVVWKNTSSRGHTITAYENAIPAEASFFATGEFESEQAAREAWNTGRENDGIIGPSETYEHTFEVPGRYDYFCIPHESESMAGAIVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSR4</accession>
    <name>R4VSR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase RecJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445109.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01310"/>
    <dbReference type="EnsemblBacteria" id="AGN00215">
        <property type="protein sequence ID" value="AGN00215"/>
        <property type="gene ID" value="L593_01310"/>
    </dbReference>
    <dbReference type="GeneID" id="16182754"/>
    <dbReference type="KEGG" id="sali:L593_01310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.267"/>
    <dbReference type="eggNOG" id="arCOG01566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_1_2"/>
    <dbReference type="OrthoDB" id="19570at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="481" mass="52041" checksum="1F65413C3539AA71" modified="2013-07-24" version="1">MSTGVTVTSMSTYAILGCGSVGHLVAEELAEQGKDLLIIDRDEGRVEALRDQDLNARTADIRDEETAAEVASMDVVLVMASDVEANKEAVRNIRAESGDAFVVVRASDPVAVDELEDLGADVVINPSNVIADFALRSLESGELEHKAAKLEEVLTGSESRVAIVTHDNPDPDSIASAAALQAIAEHVGVEADIIYVGEVGHQENRAFVNLLGIDLLDWDDVERNEYDTFAFVDHEQATDDSFDFDVDILIDHFEADSEHEAAFVDVRPNMSSTSTIMTKYIQEFDMSVDEEVATALLYGIRAETLDFKRDTSPADLTAAAYLYPFANHDTLEQVESPSMSPETLDVLAEAITNREVKGSHLVSNAGFITDREALAQAAQHLLNLEGITTTAVFGIADDNIYLAARSKDIRLNIGRVLQDAFSEMGEAAGHSTQASADIPLGIFTGIEVNEDNRETLLQLTEEAVKTKLFEAMGVESGENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VST4</accession>
    <name>R4VST4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445134.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01435"/>
    <dbReference type="EnsemblBacteria" id="AGN00240">
        <property type="protein sequence ID" value="AGN00240"/>
        <property type="gene ID" value="L593_01435"/>
    </dbReference>
    <dbReference type="GeneID" id="16182759"/>
    <dbReference type="KEGG" id="sali:L593_01435"/>
    <dbReference type="eggNOG" id="arCOG03682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044035_0_0_2"/>
    <dbReference type="OrthoDB" id="56035at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="446" mass="47702" checksum="AAFE7D8A66C50A65" modified="2013-07-24" version="1">MAIENQPGVRALIRRTLDAPADAREAVPALVDALDHDDPVVRAGVAWAICAVATAHPADAPVIVRRLDGRHGHTAAMAANWIRRELDVDAGASTASSPAPPSSSADDSADDPADSADESPSTQLSGRSESGADADDDVDRQRDEESSDDPTDSGDPIRERPDEVVQNGQFTIELARTDLDALEIVEPVESDRHSWTYAGMAGIDAERHAVLVRTYRSPLGARHSTFSGAFEDVLADWDGVDDHENVLTVHDFGRRPHPWIVTGYAPRTLRSVGRLPVQAALRVGLDAAKGLAHAHEKGITHRTLDPRSIALDSEQGRPVGKLANFGIVDAFQAVDGPLPLDSRFAAPELFDSSHGAVDWLTDVYQLGAVLYTAFAGRPPYRESLVSHGGPAGLSYEPPSSVVEDVPVAADRIVAKAMATHKIARYESADEFARDLQSALSEVEDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSU6</accession>
    <name>R4VSU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01510"/>
    <dbReference type="EnsemblBacteria" id="AGN00255">
        <property type="protein sequence ID" value="AGN00255"/>
        <property type="gene ID" value="L593_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01510"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="10628" checksum="EADE695FEA8C51B4" modified="2013-07-24" version="1">MTVPELEELVEAEPAVLAEFYSRSCPACDAQEPILGGVAREYEGVVAMVDPGEDFSALSEYGIRSTPSFVRFEEGEPAGTLADGVVGADRLLEFARTGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT55</accession>
    <name>R4VT55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445279.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02170"/>
    <dbReference type="EnsemblBacteria" id="AGN00385">
        <property type="protein sequence ID" value="AGN00385"/>
        <property type="gene ID" value="L593_02170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182449"/>
    <dbReference type="KEGG" id="sali:L593_02170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.440"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OrthoDB" id="19042at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="3">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="476" mass="53117" checksum="D2876EED464A6033" modified="2013-07-24" version="1">MSSDENELQQTNTEERFDFRKEQSAAVTSGKGLDEETIRLISEDKDEPEWMLERRLRALQQYHELPMPVDWPGAPDLSGLDIEQIVPYIRPDVEARDATDDWNDLPEEIQDTFDKLGIPEAEKKALSGVGAQYESEVVYQNMQEQWEEKGVIFCNMDEAVQEHPDLVKEYFMTKCVPPSDNKFAALHGAVWSGGSFVYVPEDVTVQMPVQAYFRMNSEGMGQFEHTLIIAEPGSEVHYIEGCSAPKYAAHNLHSGGVEVFVKEDAHVQYSTVQNWSKNTYNLNTKRAIAEKGGRMEWVSGSMGSKATMLYPSTILKGRGASDNHITIAFAGEGQDIDTGAKVYHNAPDTRSTVESKSISKDGGRTNYRGLVHIADGAEDSSTAVECDALMFDNESTSDTMPYMEIEESKVDVAHEATVGKIGDEDVFYLQSRGLDDDDAKQMIVSGFIEPITEELPIEYAVELNRLIELEMEGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTC4</accession>
    <name>R4VTC4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="5 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_02570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02570"/>
    <dbReference type="EnsemblBacteria" id="AGN00465">
        <property type="protein sequence ID" value="AGN00465"/>
        <property type="gene ID" value="L593_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.521"/>
    <dbReference type="eggNOG" id="arCOG01747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025566_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="11">
        <location>
            <begin position="35"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="12">
        <location>
            <begin position="356"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="486" mass="53760" checksum="D6C7EA69104776D5" modified="2013-07-24" version="1">MTAPRRSPTFDSTFTRPREAPPMPDPLYAVSPLDGRYAGRTEPLREYASEAALMRSRTEVEVEYLLTLADLDATPLSIDDGDRSELRSLYEEFDAEDADLIKRIETEGARGYAATNHDVKAIEYFVREGLPEGLDAANWIHFGLTSEDVNNLAHRLLVRDALADVIEPAIRDVRNELADLAREHRDVPMLARTHGQPATPTTFGKEMAVYAGRLADLHADVRVARQSLAGKLGGASGTYAAHVAAYPDVDWRSFAREFVEGLGLEFTPLTTQVNPCDDLARAFHALVRTNNVLLDLELDAWLYVSDRYLGQEAAEGETGSSTMPHKVNPIDFENAEGNLSKANSDLEFLATYVTTSRLQRDLSDSTVKRNIGAAFAHCLIGYSKTLDGLGKVVPNEQVMREELEDTPEIIGEAVQTILRREGHGDAYERVKALTRGKSVTIEDFHDLFADLDVPEDVREELRALTPAGYTGVADDLVEELEPEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUF1</accession>
    <name>R4VUF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445729.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04420"/>
    <dbReference type="EnsemblBacteria" id="AGN00835">
        <property type="protein sequence ID" value="AGN00835"/>
        <property type="gene ID" value="L593_04420"/>
    </dbReference>
    <dbReference type="GeneID" id="16180930"/>
    <dbReference type="KEGG" id="sali:L593_04420"/>
    <dbReference type="eggNOG" id="arCOG02768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_0_1_2"/>
    <dbReference type="OrthoDB" id="59035at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="311" mass="33012" checksum="3F249400F9705EB4" modified="2013-07-24" version="1">MIATMSRRAPVDMQIVSRFLALTYGISWSGVTLLWFLDVDLGSGVGAGVGTVVFMWAPAIAAIAVLRVRHRSIRNECGLYLGRIRWLLLAWIAPVGLTAVMIAVGLLLPDTTFATEYSAFLLELGMTEEEAAETVVDLEATGVPLIVLLGGMGLALGGTLFALAALGEELGWRGLLLTELAPLGYWKLSLVTGLVWGVWHTPLILLGLQFSEGPAIGIVLLTTATVALSPVYTYLTVRARSVLAATLLHGSFILGVFTSVYLANGSERVISPFGVVGIVAALIGVATCVAHDRLFADGHVTTGEPLRPWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUM0</accession>
    <name>R4VUM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444850.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGM99955">
        <property type="protein sequence ID" value="AGM99955"/>
        <property type="gene ID" value="L593_00005"/>
    </dbReference>
    <dbReference type="GeneID" id="16182310"/>
    <dbReference type="KEGG" id="sali:L593_00005"/>
    <dbReference type="eggNOG" id="arCOG03065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_4_1_2"/>
    <dbReference type="OrthoDB" id="115195at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGM99955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="117" mass="13551" checksum="A06527F075B46350" modified="2013-07-24" version="1">MSEECDETEILALLDDEYARAILGETSAQPMSATELSDRCDASRSTIYRRIDRLTDCNLLEERMRYDPDGHHRSVYASRLEEVRVTFEEAEPVLAIERTETADEDVADRFTRMWEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUR6</accession>
    <name>R4VUR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444900.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00255"/>
    <dbReference type="EnsemblBacteria" id="AGN00006">
        <property type="protein sequence ID" value="AGN00006"/>
        <property type="gene ID" value="L593_00255"/>
    </dbReference>
    <dbReference type="GeneID" id="16181287"/>
    <dbReference type="KEGG" id="sali:L593_00255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.51"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OrthoDB" id="89031at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13222" checksum="19B961B4854C1186" modified="2013-07-24" version="1">MSTGVLIVDDSHFMRNLLRQILEEEYQIVGEASNGAEAVKLYKEHEPDIVMMDIVMPKCNGIKATAAIKKLDSDARVIMCTSVGQREKMKLAVKAGADGYVTKPFEEPSVRKALKDVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVM0</accession>
    <name>R4VVM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CopG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445195.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01750"/>
    <dbReference type="EnsemblBacteria" id="AGN00301">
        <property type="protein sequence ID" value="AGN00301"/>
        <property type="gene ID" value="L593_01750"/>
    </dbReference>
    <dbReference type="GeneID" id="16179929"/>
    <dbReference type="KEGG" id="sali:L593_01750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.354"/>
    <dbReference type="eggNOG" id="arCOG04800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121270_0_0_2"/>
    <dbReference type="OrthoDB" id="118262at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="16065" checksum="CAC8FE404178D9C5" modified="2013-07-24" version="1">MGNKNKTISFRVNEDSFETLREIAEERDISLSAVFRDYVDMLVAHDGQVEVVPEHEVRDSAEEATAEFPPKVTVPKSFVREHERLELEAEHLREQLDEHKQYVTALREELDSSADADDVIHLEELDEDRGESEEPFRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVM7</accession>
    <name>R4VVM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445200.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01775"/>
    <dbReference type="EnsemblBacteria" id="AGN00306">
        <property type="protein sequence ID" value="AGN00306"/>
        <property type="gene ID" value="L593_01775"/>
    </dbReference>
    <dbReference type="GeneID" id="16181611"/>
    <dbReference type="KEGG" id="sali:L593_01775"/>
    <dbReference type="eggNOG" id="arCOG00381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102821_0_0_2"/>
    <dbReference type="OrthoDB" id="107614at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032604">
        <property type="entry name" value="DUF4897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16238">
        <property type="entry name" value="DUF4897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="23783" checksum="404AE8E32F4FEC83" modified="2013-07-24" version="1">MRATLRAAATLAAVATLIALVGATGAVAQDRPQERVNVDLQADGDAIVTTVYTYDLEDDAQQQSFANLEDERENLSTRYEARLWGVAESVSNETGREMAIQDVEATFDRRDGVGVVRLSATWTNLAAIDGDELVLSAPFDDGFDSGRPLVVRAPEGEEIVDTSVTPTEQADGQATWSAEADLSGFEVTMTTSGGGGDGQLAPSAVLPGIALLVAGGLLAVRRRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW09</accession>
    <name>R4VW09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AGN00451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9596" checksum="48EF5650BB0DF0CA" modified="2013-07-24" version="1">MHWKLFADLAEVAGSDAVDVDAGADAETVGEALDALLADRPDLATRVLDEDGEVYDHVNVLKNGSDVTATDAGLETAVEDGDELALFPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW97</accession>
    <name>R4VW97_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
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        <name evidence="3" type="ORF">L593_07775</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16296" checksum="FF297B2CFAE403D5" modified="2013-07-24" version="1">MSLDAGDSAPEIAAENQDGEVVRPSIDGPTVLYFYPRDDTPGCTTEARQFQTELESYRDAGVAVYGVSTDTVSSHREFCDDQGLEFDLLADPDAELADAFDVDTSRGAAARTTFVLLDGDIWRVYEDVSPDGHARDVLGDLLDAGVVELGE</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03200"/>
    <dbReference type="EnsemblBacteria" id="AGN00591">
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        <property type="gene ID" value="L593_03200"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
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    <dbReference type="InterPro" id="IPR038594">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04472">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP019313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="12928" checksum="69DFB514021E272D" modified="2013-07-24" version="1">MGLMSKILGGRGSRELDDYAELDVGGVDTTVEDASMQVYVAEIADQQDALEIKDAVYDGHLVVADITRLRTEDQTTEHIVEDLRQVADEVGGDIVKKGDDQLIVTPAGVKISREKLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWF1</accession>
    <name>R4VWF1_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">L593_03300</name>
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    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03300"/>
    <dbReference type="EnsemblBacteria" id="AGN00611">
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    </dbReference>
    <dbReference type="GeneID" id="16180495"/>
    <dbReference type="KEGG" id="sali:L593_03300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.668"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="107536at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="14359" checksum="8A35C49B158E70FA" modified="2013-07-24" version="1">MATKGSNYGDIHRYEPARESLAAAIAIVLLTVIEVALTGLFTYGLVEGWGIRESGNIYLGTLLGLLFINLGIILALYRKEFLPDVMIVKKRRRKWEDLYVTEDSVDGDTLGGDLGENLKRAVYPYYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWN8</accession>
    <name>R4VWN8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08550"/>
    <dbReference type="EnsemblBacteria" id="AGN01655">
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        <property type="gene ID" value="L593_08550"/>
    </dbReference>
    <dbReference type="GeneID" id="16180521"/>
    <dbReference type="KEGG" id="sali:L593_08550"/>
    <dbReference type="eggNOG" id="arCOG09073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089546_0_0_2"/>
    <dbReference type="OrthoDB" id="129318at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="18668" checksum="753EB609501489D8" modified="2013-07-24" version="1">MHEETRSWVELLALQLAGLVVATHLYWGLDRFAEQLRYGVYVDPRPVLFVLSSAAIIAGAAYVALGGRRKPVYALGIALMLVYLFGYWGWHLMGHLPALPWVDDQSHPHPGWGPFETLYRHLAADHLALVSKLAEATLALVLGALWLDERTAAEDGAALADETNSEADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWW6</accession>
    <name>R4VWW6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08775"/>
    <dbReference type="EnsemblBacteria" id="AGN01700">
        <property type="protein sequence ID" value="AGN01700"/>
        <property type="gene ID" value="L593_08775"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1798"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="40509" checksum="76FB3EFB39952405" modified="2013-07-24" version="1">MTVTDPLLVLGVLAAVFVGFNIGGSSTGVAWGPSVGAKIINKTLAATVMTFFVFLGGWTIGRNVIETLGGELVPQSAFSLEASIVVLAFIGLGMLAANVYGVPVSTSMTAVGSIAGFGLATGDLDMAVLGGIVVWWILAPITGFWCGGVIGRYLYPYLDRRFSLDQSEGPLVDYDWRGPIPLPHLGPGTTPKEFASTMIVFAIACYMSFSAGASNVANAVAPLVGGGAVSVSAGVFLATAAIGLGAFTIARRTMESVGNDLTALPLLAATIVMVVAASITTIASWLGVPISLAMSTVMTIVGLGWGRATRTATAKEIVTGEAETAISVDAITSETPEEPSRIGEETPEDMQAVDQLFDPDAVVRFVSFWIIGPGMATLLSYGAFAIGNRLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX26</accession>
    <name>R4VX26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446664.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09125"/>
    <dbReference type="EnsemblBacteria" id="AGN01770">
        <property type="protein sequence ID" value="AGN01770"/>
        <property type="gene ID" value="L593_09125"/>
    </dbReference>
    <dbReference type="GeneID" id="16182625"/>
    <dbReference type="KEGG" id="sali:L593_09125"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="16129" checksum="3BC833E3959CEC42" modified="2013-07-24" version="1">MHFVVCVDGSEQSDRALEHAADLVDATDGSLTVVHVVEPKVYEQAGEGPISTRSEGEKSLVLEGIEDAENRGEEVLEEAREAVPFEVEDVLLYGDADDAIAQYVETREGIDGVIVGHRMVSERRREMLGSVARGLIELSPVPVTVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX31</accession>
    <name>R4VX31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445715.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04350"/>
    <dbReference type="EnsemblBacteria" id="AGN00821">
        <property type="protein sequence ID" value="AGN00821"/>
        <property type="gene ID" value="L593_04350"/>
    </dbReference>
    <dbReference type="GeneID" id="16180913"/>
    <dbReference type="KEGG" id="sali:L593_04350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.885"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="335" mass="37582" checksum="FC0BF54602E9533D" modified="2013-07-24" version="1">MEYVRLGETGLEVSPLCLGTWRFGEESGDVVETDREAAHELLDAFAEAGGNFIDTANGYGGGNSEKWIGEWLEDQDREDFVIASKCYWSQVSRFQENLSRKNVRAEVEGSLERLGTDYLDILYLHRWDDETPIENTLRTLDDLVSEGKVHNIGLSTADGWKLMKGLWKADVNNYEAFTVTQPMFHAAYKEDVADYLDVAADQDLAVCPYSPLAGGFLTGKYERVGDGTYDVDVPEGSRGDITDVFDDWYVSERGWHVLDAIREVADEEDATPAQVALAWLMAQEDFTCVPIVGARTTDQLEENVGAVEVDLSDEQFDRIDQARYAEDGEVYESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX36</accession>
    <name>R4VX36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445720.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00826">
        <property type="protein sequence ID" value="AGN00826"/>
        <property type="gene ID" value="L593_04375"/>
    </dbReference>
    <dbReference type="GeneID" id="16180920"/>
    <dbReference type="KEGG" id="sali:L593_04375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.890"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="36288" checksum="FE24FA80B5A8157C" modified="2013-07-24" version="1">MNLSKGFVLALVATLLVLSAMLIQPFLQYVLAAVLIAYLLYPLQIRLEAHVSPALAALSLVFVAVAGFVTPFVVILATVLESADRIPRDLDAEQGQLEGIETRIEELTGLEVDIVGALVGSGQEFGTIVFERSIQAIGTITFHLIGILLALFLVYYLLKDGDDLFDWLLRTVPLPTDVQHDLYDEIDDVMWGVLFGHVFVAIVQGVVAGIGFAATGVPNAVFWTAVMIVLAMVPLIGAIPVWGGAVVYLYLTGEPLLAVGLFVYSVVVVGLTDDYLRPFAVDRYAKLNPAVILLGILGGAYAFGIMGLFFGPVVLGALKATLRVGLENWSRIGGSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXD2</accession>
    <name>R4VXD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445815.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04860"/>
    <dbReference type="EnsemblBacteria" id="AGN00921">
        <property type="protein sequence ID" value="AGN00921"/>
        <property type="gene ID" value="L593_04860"/>
    </dbReference>
    <dbReference type="GeneID" id="16181124"/>
    <dbReference type="KEGG" id="sali:L593_04860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.993"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="390" mass="40221" checksum="C3CE027C4E95E81F" modified="2013-07-24" version="1">MTEVTTAVILAAGEGRRLEPLTNRRPKPMLPIVDQPLLEYVLEAVVDAGIEHVVFVVGYERDRIQTHFGDGDDWDVEISYALQETQLGTGHAVVQAESLVDGPFLVLNGDRIIDTETVQSVRSALQSGDDGPAMAVTRSATPSEYGVVNVQGDRVVDLVEKPREPASDLINAGVYGFTQAVFEAIRGTPTDDDGEQSITATIDRLLADGTVRAVRNDGLWLDVSHLWDLPSVTGRMLDRDGGAVAGSVAESATVADATHLASGSRVGANATIGRGTTLADNASVGANAVVERSVVFPDATVGPGAVLRDCIVGANATIGANATVPGGEATVIVEGTVHEDVRLGGVIGDNASIGGGAVLDPGAILYDDAEVAPGASASGTVGEGTVIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXX8</accession>
    <name>R4VXX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DoxD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447019.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10900"/>
    <dbReference type="EnsemblBacteria" id="AGN02125">
        <property type="protein sequence ID" value="AGN02125"/>
        <property type="gene ID" value="L593_10900"/>
    </dbReference>
    <dbReference type="GeneID" id="16182037"/>
    <dbReference type="KEGG" id="sali:L593_10900"/>
    <dbReference type="eggNOG" id="arCOG02861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124808_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007301">
        <property type="entry name" value="DoxD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04173">
        <property type="entry name" value="DoxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DoxD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="19772" checksum="0D984A584D1D8369" modified="2013-07-24" version="1">MPNETATVDTRLFGRDVTYSFDGPWGAYWMVFLRVIAGWWFLNAGLGKVLEQGLLYDTTGWLEFGTKGSILYPMFEWFAVNAAFVPNFMVPWGQIAIGLGLIFGVLTRLAAANGMILGTFFYLGNAGWGHGFVTSELFGIMIFGTILVIGAGRIYGVDGYLETTKLVEQHPRLRYLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXY2</accession>
    <name>R4VXY2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447024.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10925"/>
    <dbReference type="EnsemblBacteria" id="AGN02130">
        <property type="protein sequence ID" value="AGN02130"/>
        <property type="gene ID" value="L593_10925"/>
    </dbReference>
    <dbReference type="GeneID" id="16182401"/>
    <dbReference type="KEGG" id="sali:L593_10925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2254"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="3">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="35633" checksum="6021BBA7B20F9BF7" modified="2013-07-24" version="1">MQCSKCDREAVTHVAYAGTHLCESHFLRSVEKRVRSRVREDGLLPDDATPEDPVTWVLGLSGGKDSVVLGAILQDTFSEDPRVDLLALTIHEGIDGYRDESVEAAESFAEAYDVPLELVAYDDEFDVRMDDVAADDPLDMAPCAYCGVFRRDVLERYADDLGADLLLTGHNLDDEAQTALMNVLEGDVAQIAKHFEASLGPLDDRAEQDEFVPRAKPLRDVPESEVALYGHLRDLPAQIAECPHAEEAYRGEIKSLLHGLEDDHPGTRHSILSGYEELARLAADARESNADESDSAAGDLGECESCGSPTASDVCRTCSLLEALDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY52</accession>
    <name>R4VY52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02190">
        <property type="protein sequence ID" value="AGN02190"/>
        <property type="gene ID" value="L593_11225"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11225"/>
    <dbReference type="HOGENOM" id="CLU_1976630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13228" checksum="5281D83D5F878A2E" modified="2013-07-24" version="1">MAIGFALLPALGVYLLASLASFGELLLAVILSLPLFAILIYRKRTVTGMASATLFWLAAEAFFAPVVAYVYISSTVDASNSSGIDEAVAGIQGGILLVLAFVVCIPLGIGFYVLSKRVQERPTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYQ5</accession>
    <name>R4VYQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446265.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07120"/>
    <dbReference type="EnsemblBacteria" id="AGN01371">
        <property type="protein sequence ID" value="AGN01371"/>
        <property type="gene ID" value="L593_07120"/>
    </dbReference>
    <dbReference type="GeneID" id="16182011"/>
    <dbReference type="KEGG" id="sali:L593_07120"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076274_1_0_2"/>
    <dbReference type="OrthoDB" id="57867at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="240" mass="26322" checksum="9F689AC1359494CA" modified="2013-07-24" version="1">MGYLAEYTVHCDSLPLVDVARRVPEATLTVQVGQPNQGGPPPFAVTVRGPAPDEAEAALDASPFVAEKVRLAADADARRYRIVPATTMEEQLGPAVSDVERLRDLAATEAVLEHVEVVRDGWRQRRRCVDRAAFENYWSFWREEHSVTIHRLVESPECETGTPATDALSDRQREALLMAFELGYFEVPRGATLADVAAELGISAASASERLRRAQRALIAANLDAPGAGVQRDLIKRHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYX3</accession>
    <name>R4VYX3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase II small subunit</fullName>
            <shortName evidence="12">Pol II</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="12">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">polB</name>
        <name evidence="15" type="ORF">L593_07505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EC" id="3.1.11.1" evidence="12"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446340.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07505"/>
    <dbReference type="EnsemblBacteria" id="AGN01446">
        <property type="protein sequence ID" value="AGN01446"/>
        <property type="gene ID" value="L593_07505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182152"/>
    <dbReference type="KEGG" id="sali:L593_07505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1537"/>
    <dbReference type="eggNOG" id="arCOG04455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027850_0_0_2"/>
    <dbReference type="OrthoDB" id="24499at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="PTHR10416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_E_B" evidence="14">
        <location>
            <begin position="275"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AGN01446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="527" mass="57468" checksum="1A1A1CF039CC27E4" modified="2013-07-24" version="1">MPLETSARIVRELAGHGYNVEREAVTLIASAPDPAATLAAAVEATPDDEPVVETDVVRAVRDDAREDSGSSTGLDDPNVSTGDHTTGHQVQGEVAPETEGSAPPSTTGTAATAQSTPTGDADRSTTGRSLEIAGDITGESTGTGDYADFVSLFRDRYDKLSKQLRGRVNHRPTDTLESMPGGSEAAIVGMVDDVRSTANGHHLLDLEDANGTFPVLITKDRDIAEHVDEILTDEVIAVEGTISDDGGILFVDDLYFPEIPRTFEPTTADRHVQAALISDVHVGSQEFEADAWNRFADWLHTAEAEAIEYLLIAGDMVEGVGVYPDQDEELDVIDVYEQYETFAEHLKAVPGDVEIVMIPGNHDAVRLAEPQPAFDEELRDIMSAHDARITGNPSMVTIEGVSVLMYHGVSLDEMIAELPEEKANYDEPQKPMYQLLKKRHVAPKYGGHMRLAPEKEDYLVIDEVPDIFHTGHVHKLGYGKYRNVLAINSGCWQAQTDFQRSVNIDPDVAYAPIVDLDTLDVTIRKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZA2</accession>
    <name>R4VZA2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446480.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08205"/>
    <dbReference type="EnsemblBacteria" id="AGN01586">
        <property type="protein sequence ID" value="AGN01586"/>
        <property type="gene ID" value="L593_08205"/>
    </dbReference>
    <dbReference type="GeneID" id="16181128"/>
    <dbReference type="KEGG" id="sali:L593_08205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1684"/>
    <dbReference type="eggNOG" id="arCOG01628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049427_0_0_2"/>
    <dbReference type="OrthoDB" id="37761at2157"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="75"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="279"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="41461" checksum="871BDB9926C4F58B" modified="2013-07-24" version="1">MSEATGDWRASIDDVDARILDGFQSGFPIEERPFRVVAEAVGTDEQDARDRVEALLDRGLLRRFGPVLNPPVIGASTLAALKVPEGDGERTAVDGERTTGDGDRTADGNGTAEDRFAAVAEVVNGHEQVNHNYRRDHEWNMWFVVTAGSLDRRDEILAEIAEETGLEPLVLPMLTDYYIDLEFPVVNDDRFARESAAAEGVEATRIAESARGDLSAFDADLLLAIQEGFPVSTTPYRDVAASLPAEHDATVADVLAGIERLSDAGCVKRIGCIVNHVATGFDSNCMVVWDVPDDELDDRGSAVGGLPYVTLCYHRPRRPERDWPYNLFTMIHGRDADAVDRKVDELAEEYLPVEHERLFSTETLKQTGARYEALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZC7</accession>
    <name>R4VZC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447524.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13455"/>
    <dbReference type="EnsemblBacteria" id="AGN02630">
        <property type="protein sequence ID" value="AGN02630"/>
        <property type="gene ID" value="L593_13455"/>
    </dbReference>
    <dbReference type="GeneID" id="16180635"/>
    <dbReference type="KEGG" id="sali:L593_13455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2752"/>
    <dbReference type="eggNOG" id="arCOG04607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059556_0_0_2"/>
    <dbReference type="OrthoDB" id="42972at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="320" mass="35548" checksum="1428EE09799B797F" modified="2013-07-24" version="1">MTIYHSVRAVANASGDGLIDWDAVTEAACAATEPGSLALTAADREGYASDVRDARRRVRAVTTHEFVVPETLEIQHRHHWVDANVETFREVMRPLEGMADEALVPGLARKTNTASMSVMLGYLARNVLGQYDPLLLADSPQDAHGLYFVHPNIVAVAETLDVDFERFRRWIAFHEVTHAAEFGAAPWLSDHLAERMERGIDGVADGNIDRETFAELQTAMTAVEGYAELLMDEAFDDESDDLRAKLDDRRAEAGPVGRLLRRLLGIGLKREQYERGKSFFDEVADARGLAAAGAVWESPDHLPTDEELDEPALWLQRIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZX3</accession>
    <name>R4VZX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447699.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14330"/>
    <dbReference type="EnsemblBacteria" id="AGN02805">
        <property type="protein sequence ID" value="AGN02805"/>
        <property type="gene ID" value="L593_14330"/>
    </dbReference>
    <dbReference type="GeneID" id="16181206"/>
    <dbReference type="KEGG" id="sali:L593_14330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2933"/>
    <dbReference type="eggNOG" id="arCOG04640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073601_0_0_2"/>
    <dbReference type="OrthoDB" id="52696at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="30820" checksum="75149347CC8D2611" modified="2013-07-24" version="1">MYGVVTRNEPETEWAEFDHAFYEVKDVTGRGAEPIESAVNMVSCFGDTAAVEAEPDLAAVDADGTPATRDQQYFDWSYVCPTREDYRAGVLATIEDCVAVQPDVRLDDVGFPRAGYCRCETCRDQFAQSDHDEWQDWRAAVISDFVADAVDRIPGRTYLTLYPDPYPGHLFERSGIDVEALEPLVDEFVVPLYDTAYGTTYWLEAIANGFADRISDADLAIELYAVDVEIDPLIHATEVAQAAADAVYFGYDASNARAAIRRLEADARDGVAHGENAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W070</accession>
    <name>R4W070_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="4">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ImGP synthase subunit HisF</fullName>
            <shortName evidence="4">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisF</name>
        <name evidence="6" type="ORF">L593_14880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447804.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14880"/>
    <dbReference type="EnsemblBacteria" id="AGN02910">
        <property type="protein sequence ID" value="AGN02910"/>
        <property type="gene ID" value="L593_14880"/>
    </dbReference>
    <dbReference type="GeneID" id="16181561"/>
    <dbReference type="KEGG" id="sali:L593_14880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3039"/>
    <dbReference type="eggNOG" id="arCOG00617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_2"/>
    <dbReference type="OrthoDB" id="57066at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="29185" checksum="A282486682C2BFF3" modified="2013-07-24" version="1">MGLTKRIIPCIDVDVDDEGNAAVYTGVNFEDLEYTGDPVEMAKRYNESGADEFVFLDITASADGRETMLETVSAVADEVFIPLTVGGGIRTKADVKETLRAGADKCSINTGALERPELIEEGAAAFGSQCIVISVDARRRFDEQGEYYAEVDGESCWFECTVKGGREGTGQDVVEWSKEAESRGAGELFVNSIDADGTKDGYDIPLMNAVCDAVSTPVIASSGCGGPEDAYEVFTEADADAALAASIFHFDEYSIREVKEYLDERGVPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1G0</accession>
    <name>R4W1G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_914053_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="304" mass="35349" checksum="165BA57D8D2F9B98" modified="2013-07-24" version="1">MALMNGEIGSLDSLYHEDDLFQGKKIDAQALWTLYGAMLHIGDEPEDAARNAYIYYYRSCEQDGERRRFIIEGEGYRVNQLNDAIEIFDKGDWNRWFRRKHPDGFDEEDFESWTGDYSNITYDTIRALVYITSTEFDPEYVLHDLFELDYDPSSEHIQNLANGVFDEYTRRTKSFHKIGAGSNPSPYRDSARYRYAPKEAIVNVAMEIDGRSKSTYDNAIGQLHKKGVLKWAEIRPGQDYRIYPTTIDDPPEANRIKFEGEEYVPEPEEESEPELMTDGGQPMSEESRESTERKSEQVQSDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1Q6</accession>
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            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="GeneID" id="16182234"/>
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    <dbReference type="eggNOG" id="arCOG01208">
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    </dbReference>
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    <dbReference type="OrthoDB" id="108083at2157"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
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        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="30389" checksum="3957E1E58C0347FE" modified="2013-07-24" version="1">MHDHHREATDAVVADVRDREEFLACVLSGSVARGWERPDSDVDFVIVATEEEYDRRRADWDLQYYREDVSDRDGVYADGKIVTHAFLEEVAENGSEPARSAFVDCSVEWTGDPAIAETIAEIPVYPEDERIDRIETFYSQMQAYRWFVDEAAARENPYLRSYAATQLALFGGRLLLANDRTLFPYHKWLTRELREIEATPNGIADRMETLVEEQTPEAAEAFVEPIEEYRDWETPEAGWPVRFMLDREWQWRRGEPGLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1X0</accession>
    <name>R4W1X0_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02661">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02911">
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    </dbReference>
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    <dbReference type="OrthoDB" id="104116at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="246" mass="25989" checksum="F79AB3F769D4D538" modified="2013-07-24" version="1">MTDRAVSEVIAFVLIFSIVITSVGLLYTAGFGSITQIQESETDRSAERAFGAMAVALDDIQAGRGSQRAIDLELSGRTLSVNDSASLTARIDGGSPTTVDGALVYGRGTGTEIVYQSGAVIRSDGPDSQLVSRPPRFSCRDEHAVVSLVSIDGPSRSVSTDGSLSLVASGPREDESTIAEARHDSPVGSPPYNVTIDFGGSGYETAWRSYFEDEDGWSVSGTTAECTDVDTAYVRVVPLELTYRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2C1</accession>
    <name>R4W2C1_9EURY</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02816.1"/>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14385"/>
    <dbReference type="EnsemblBacteria" id="AGN02816">
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    </dbReference>
    <dbReference type="GeneID" id="16181237"/>
    <dbReference type="KEGG" id="sali:L593_14385"/>
    <dbReference type="eggNOG" id="arCOG09087">
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    </dbReference>
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    <dbReference type="OrthoDB" id="49502at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="52"/>
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        </location>
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        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="265" mass="29925" checksum="B28F4082B4DD4EF6" modified="2013-07-24" version="1">MSDLSPTFGSWRDRLTYLVAEAQLLVAGLLISLGIMVLWFQPKLPGVPGWVYGAIAATLLIGPILFGFFMSFIGWLRTRHWVTVHHINGVTDTREKYKVSPEVWAEKTVEGPSPYRVNDGDAFEVREFDYYDDQDELIVTGAYFSKLADSKLITVQAMLEDIHGQLIETAIAYNKLRGRISRMGVEIERDVVNFQAEADERGLMGRKTAVKERFEAAEEEAQEWDTDEIKDLGDYELDYDPVENPRGEPLEPSDRPAATDGGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2E6</accession>
    <name>R4W2E6_9EURY</name>
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    </gene>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02851">
        <property type="protein sequence ID" value="AGN02851"/>
        <property type="gene ID" value="L593_14560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14560"/>
    <dbReference type="HOGENOM" id="CLU_2613794_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="78" mass="9103" checksum="61932C774DE74A2B" modified="2013-07-24" version="1">MHRQQSLSLCKTVPEDTDDEKDNARFNHTNVRGLTHFATKAPPISNQTSACLIFVRILCIFTFLFLTIQFIHVRNRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2E9</accession>
    <name>R4W2E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447750.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02856">
        <property type="protein sequence ID" value="AGN02856"/>
        <property type="gene ID" value="L593_14600"/>
    </dbReference>
    <dbReference type="GeneID" id="16180109"/>
    <dbReference type="KEGG" id="sali:L593_14600"/>
    <dbReference type="eggNOG" id="arCOG06206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191916_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="7697" checksum="512681FEFDCBFFA9" modified="2013-07-24" version="1">MTGYYDLILALIPIALLGIGGALLVAGVPQSVAVSLAGTTAFGMMGHAIFVNGPVETAASTAASTSQTQSSGSTAIQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2G7</accession>
    <name>R4W2G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447775.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14735"/>
    <dbReference type="EnsemblBacteria" id="AGN02881">
        <property type="protein sequence ID" value="AGN02881"/>
        <property type="gene ID" value="L593_14735"/>
    </dbReference>
    <dbReference type="GeneID" id="16180505"/>
    <dbReference type="KEGG" id="sali:L593_14735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3009"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="477" mass="51138" checksum="4377A3202340942C" modified="2013-07-24" version="1">MSHRPGIVGLIATEDGGVAEIETALTERGHEVRAATEVESARKLANERAVDCLVVAGGDGVDVVAVLSVINEADALLPTVCYPYAGSEALAARTIELDVDTYVPRSAGLESLVAAVDDACAAGDDPLRDAEGMLRTLTDAVPVSLSIYFKDAMGRHLHVSEHFPKLIGPPYMETPDEKIIHHPADALGMTDFDLYGPELGVETAADEERIMKTGEPIVDKLEDASESGDEDYYVSTTKAPWYDSTGRLRGIVGVTIDVSERERNRRTLARQNERLERFASTLSHDLRNPLAIAQGRLRELEGDSEAVADVEWALDRMDQLISEMLELARQGSVVDDPEPVDLALPARHAWDTVAAGGTLTVGDLRTVEGDPERIRTLFENLFRNAVEHGGDDVAIAVQDTADGFAVTDDGPGIPGDDPSEIFEHGFTTRADGTGFGLSIVREIADAHGWTIDATNGAAGGARFDVRVVHPPDGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2K8</accession>
    <name>R4W2K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447830.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15010"/>
    <dbReference type="EnsemblBacteria" id="AGN02936">
        <property type="protein sequence ID" value="AGN02936"/>
        <property type="gene ID" value="L593_15010"/>
    </dbReference>
    <dbReference type="GeneID" id="16181660"/>
    <dbReference type="KEGG" id="sali:L593_15010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3065"/>
    <dbReference type="eggNOG" id="arCOG02608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_8_2_2"/>
    <dbReference type="OrthoDB" id="124641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9356" checksum="B01FA9FB3E7137D3" modified="2013-07-24" version="1">MADSGLVLYELEGCPFCAKVTTKLDELGLDYESRQVPRSHGQRTEVQEISGQTGVPVLVDPEHGVEGMPESDDIVAYLEKTYGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2M6</accession>
    <name>R4W2M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_00410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444931.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00037">
        <property type="protein sequence ID" value="AGN00037"/>
        <property type="gene ID" value="L593_00410"/>
    </dbReference>
    <dbReference type="GeneID" id="16181457"/>
    <dbReference type="KEGG" id="sali:L593_00410"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053272_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="34098" checksum="B383A5319BA3700F" modified="2013-07-24" version="1">MPDAGSSPDIPTPPGGIGEEAAVLDANRTTVQRLSLPRSARRIVLVLGLGYALSLLVFVVGFGGRAGGTVVVPSVVIVAFVLESTDSATGMGFGTGLAPLLFVFGYEPLAVVPALLLSESVTGLLSGLLHHEMNNVTFRLRPPNREIRLVVLLILLSTVALVISVTLVHALAILPQGFVEAYVSVLVVLMGAFGLLRTRIGTPEVFRPRRLVGFALFAGASKGIGGGGFGPVVTLGQILSGVYEKSAVAITSASEGVLSLVGGLTFLVFWYLGEPVDFLLVPSVLTGGFFAAILAPYLVRVVPNSVWQYLIPGYAVVIGVAGVVLGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V6</accession>
    <name>R4W2V6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="6">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">gltX</name>
        <name evidence="10" type="ORF">L593_01120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445071.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01120"/>
    <dbReference type="EnsemblBacteria" id="AGN00177">
        <property type="protein sequence ID" value="AGN00177"/>
        <property type="gene ID" value="L593_01120"/>
    </dbReference>
    <dbReference type="GeneID" id="16181899"/>
    <dbReference type="KEGG" id="sali:L593_01120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.229"/>
    <dbReference type="eggNOG" id="arCOG04302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_3_2"/>
    <dbReference type="OrthoDB" id="8922at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="107"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="9">
        <location>
            <begin position="420"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="571" mass="63975" checksum="A1BC08FE2280E559" modified="2013-07-24" version="1">MDEDLRDRVRAAAETHALINAVKHESDPEVGPIMGPLMGDHPEFREHGDEVPGVVGQVVAEIGDLDHEARRERLAELDPEALADIEAEDEGEEHALPDLPNADEYDQIRMRAAPNPNGPWHIGHARMPAVIGEYAERYDGWFCVRFDDTDPETKRPDLSAYDAILEDVEYLGFEPDAVYRASDRMETYYGHARELIEAGGAYTCSCSGEEFSELKNSGEACPHRDQDPDETLADFEAMVDGEYSAGEKVLRVRTDIEHKNPALRDFVAFRMVDTPHPREEAAEYRCWPMLDFQSGIDDHELGVTHIIRGIDLQDSAKKQRFVYEYFGWDYPEVIHWGHVQVDAYDVPMSTSSIKQLIVEGELDGWDDPRAPTLKSLRRRGIRGQAIVEAMAGLGTSTSNVDLAMSTIYANNRELIDDESDRYFLVRDGLEVPLTGGPDEANPPLHPDFEERGARSIPVGDTVMIEADDLPGHGQRVWLKGLGCVENIRDAFQFTGDSIDVVKSGEVDVIHWVPGSQSIPCRLRTPDGDVQGRAEPQVADLDPDEVVQFERVGFARIDRHDDAETVAYFSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W341</accession>
    <name>R4W341_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01720"/>
    <dbReference type="EnsemblBacteria" id="AGN00297">
        <property type="protein sequence ID" value="AGN00297"/>
        <property type="gene ID" value="L593_01720"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01720"/>
    <dbReference type="eggNOG" id="arCOG04729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284981_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="13476" checksum="4809746AA70C21C7" modified="2013-07-24" version="1">MVTMTDADDPEPNGDAATPRDSTDAEDAEREPSTDEESGSSGFLGNIKNARSQLGDAKDAFSNARSAGSLPTDEEGRVRLVCRRYEERRLAPLDDKGRPSCYEAGNEDCEDCVEAVREGSVETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W392</accession>
    <name>R4W392_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02180"/>
    <dbReference type="EnsemblBacteria" id="AGN00387">
        <property type="protein sequence ID" value="AGN00387"/>
        <property type="gene ID" value="L593_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.443"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1222571_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="26103" checksum="6EBC9A3699265808" modified="2013-07-24" version="1">MLRVSGSQSGYQKLTDLRKYHNPDRDEDVAQEIYDLLADGEMVIVDISNGLEKVVTSEKERIVGKLLDESMERFRDAEPDEELPKIQVYLEEAHQHFEEYRENESMNPFVTLAKEGAKFEIGMAYSTQEVTSVDARVRANTANWIVTHINSKRETNELSKYYNFEDFAESIRNVETVGYARAKTYSGEHIVPIKVSMFDTEWVRNNTQFGVKKDGEFIVSRPADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3C0</accession>
    <name>R4W3C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53720"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="483" mass="51906" checksum="F61E210F1CF4A3CC" modified="2013-07-24" version="1">MEYTGPTECYVGGEWTTSSDGETIETEDPATEEPYATVQRAGPDDVDAAVEAARSAVERGSAWRTMAPEERRERLHAMADAIEDFEDELTMVESHDNGKTPFEAGMEIGMVVDTFRYYAGWTDKLEGSEIPVEAGRLNYTRREPVGVTAHVSPWNYPFQLAGRSIAPALACGNSVVLKPSELTPLSALYYAKAAEAADLPDGVLNVIPGYGHDAGSALTSHEDVDHVTFTGGTDTGRSIQRDAAEHVTDVTLELGGKGPALVFPDADLDAATTGIQYGIFMNAGQMCWANSRVLAHEDVYEEVVERMVGIAESIPIGGGIDDDGRMGPLVSEQRQSAVLEYVEEAQAEGATVAAGGGVPESKDAGHYVEPTVLTDVTNDMTVAREEVFGPVLSVIEVADEDEALAVANDSPYGLTACLWTNDLTRAHTLADRLDYGMVMVNETPNTWPQTPFGGTKQSGHGRQQGREAIDAYTEVKNVHVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3F4</accession>
    <name>R4W3F4_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445391.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02730"/>
    <dbReference type="EnsemblBacteria" id="AGN00497">
        <property type="protein sequence ID" value="AGN00497"/>
        <property type="gene ID" value="L593_02730"/>
    </dbReference>
    <dbReference type="GeneID" id="16180384"/>
    <dbReference type="KEGG" id="sali:L593_02730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.553"/>
    <dbReference type="eggNOG" id="arCOG06383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393616_0_0_2"/>
    <dbReference type="OrthoDB" id="74488at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="22263" checksum="283F60E74BD58103" modified="2013-07-24" version="1">MTTLPTWIEDRLDPNLDHKLTQRHVVETMLEAERPFFSVTQLQVRLKPDVSGETVRNRLDELREIDVLAAETYPDTITLYYVNHPQSNWPLSPEGHEALTRTNPLDRLSLRDFLTLSDPAGIRTLVLAGLQLSFLTFCLGVVFSALGIHELVSSTQSFWTTSVSLLLVSIALLGAERLARWARGRDGTISSGDRHTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3T4</accession>
    <name>R4W3T4_9EURY</name>
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        <submittedName>
            <fullName evidence="7">Proton-translocating NADH-quinone oxidoreductase, chain N</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">L593_03805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445606.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03805"/>
    <dbReference type="EnsemblBacteria" id="AGN00712">
        <property type="protein sequence ID" value="AGN00712"/>
        <property type="gene ID" value="L593_03805"/>
    </dbReference>
    <dbReference type="GeneID" id="16179959"/>
    <dbReference type="KEGG" id="sali:L593_03805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.772"/>
    <dbReference type="eggNOG" id="arCOG01540">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_1_2"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="133"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="502" mass="52280" checksum="CFC22DE3A6241935" modified="2013-07-24" version="1">MALDTLGGEDWFLHMAPALLMIATAIALFGVDAIDPESTNHPAVFGVTIVGTLAALGSAVALLLGFGPETGTTLFADQLVADEGSLLFTVIVTSVTSLVVLGSYDYIRDLPDKGEFYSLTLLAATGMVLMAHANSLATVFVALELASLPSYALVAFLKHNRGSVEGGLKYFLIGAVSSAIFVYGISLVYAATGSLQLSAVGTAVSEGVDQTGVLGLGVLLMVAGFGFKIASVPFHFWAPDAYEGAPAPISGFVSSASKAAGFLIAFRVFTTAFPIGPMQDAGIDWVFVFGVLAVLTMLLGNLAAATQDEVKRMLAYSSVAHAGYVLIALAALKDGGTYNDWVLAGGMLHLFVYGFMNTGAFLFVALAEQWDVGRTFEDYAGLGEEAPVASAAVTVMLFSLAGLPVGGGFWSKFMLFGGAIENGFWWFAAIGLAASALSLFYYWRLIRALWIDEPEHGGHDLGSKPTSLYVAVLIAALVTVALLAAVGPVENVATDAAQALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4B8</accession>
    <name>R4W4B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445926.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05415"/>
    <dbReference type="EnsemblBacteria" id="AGN01032">
        <property type="protein sequence ID" value="AGN01032"/>
        <property type="gene ID" value="L593_05415"/>
    </dbReference>
    <dbReference type="GeneID" id="16179902"/>
    <dbReference type="KEGG" id="sali:L593_05415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1106"/>
    <dbReference type="eggNOG" id="arCOG00450">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147145_0_0_2"/>
    <dbReference type="OrthoDB" id="90849at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14669" checksum="0F09B0C6B1D0D7AE" modified="2013-07-24" version="1">MPTSITDHLLVPVANEEDARATAAILGGYECDRVTVVHVVEKAGGAPDKLSVEQAEQRAEDAFAAFRETIPNAATELVYHRDVVGATVDTAADVQASAIAFRPRGGSRIVQFLSGDTALKLVTEADRPVIALPEGDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5D9</accession>
    <name>R4W5D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446571.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08660"/>
    <dbReference type="EnsemblBacteria" id="AGN01677">
        <property type="protein sequence ID" value="AGN01677"/>
        <property type="gene ID" value="L593_08660"/>
    </dbReference>
    <dbReference type="GeneID" id="16181240"/>
    <dbReference type="KEGG" id="sali:L593_08660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1775"/>
    <dbReference type="eggNOG" id="arCOG04728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121763_0_0_2"/>
    <dbReference type="OrthoDB" id="102952at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15290" checksum="1D3227CAC4B92062" modified="2013-07-24" version="1">MQVRDAVEDDAAAMAAIADAPQDVMRNLVHDRTVRVAEPDIVDDDPNEDAGARDPQLLGFVSFDARQDAVHVTQLDGTDEACELLLSEPVRFAERESMAVELLVSEAQDGVADAARNQGFADVGPGPRFEGVPTTRYRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5H5</accession>
    <name>R4W5H5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_08860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446611.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08860"/>
    <dbReference type="EnsemblBacteria" id="AGN01717">
        <property type="protein sequence ID" value="AGN01717"/>
        <property type="gene ID" value="L593_08860"/>
    </dbReference>
    <dbReference type="GeneID" id="16181892"/>
    <dbReference type="KEGG" id="sali:L593_08860"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1817"/>
    <dbReference type="eggNOG" id="arCOG04237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_2"/>
    <dbReference type="OrthoDB" id="39666at2157"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="42537" checksum="FE61864AD384BB45" modified="2013-07-24" version="1">MLEDVQKGLEGVLVAESGLSSIDGDAGRLIYRGYDIETLAREATYEEVLYLLWHDELPTAEELEAFADSIAEERELSADVLETVRRLAASGEEPMAALRTAVSALSADEPEPDADPEDLDATLRKGRRITAKIPTILAAFERYRMDEAPVDPHPDLDLAENFLYMLTGEEPDDIAAETIDQALILHADHGLNASTFTSMVVASTMADVYSSVTAGIGALSGPLHGGANQDVMEMLIEVDESDRDPLDWVKNATDEGRRIPGFGHRVYNVKDPRAKILQARCKELSEANGDEKWYDYTTTIEEYLTEEQGLVEKGIAPNVDFYSGTVYYQLGIPVDMYTPIFAMSRVGGWVGHVLEYQEDNRLIRPRGRYTGPEEAEWVPIDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5I9</accession>
    <name>R4W5I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446641.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01747">
        <property type="protein sequence ID" value="AGN01747"/>
        <property type="gene ID" value="L593_09010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180525"/>
    <dbReference type="KEGG" id="sali:L593_09010"/>
    <dbReference type="eggNOG" id="arCOG04731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544167_0_0_2"/>
    <dbReference type="OrthoDB" id="94733at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="170" mass="17270" checksum="1B5C1027BB373EE5" modified="2013-07-24" version="1">MGLSDIAADLEVTAEQRDRGVATVDETDGDLAERLVPVAEDLPCSAAAAADLVDAYADGASVGGAGKAAGLPPITAAKVLHLVGVDGVCPLAPVAREIVTDWIAGDLPRTEARELAGASETEFLLTTFLETHEPIPAAREAVEPVLGPGDAPLSTDDALAETMADAGEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y3</accession>
    <name>R4W5Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10310"/>
    <dbReference type="EnsemblBacteria" id="AGN02007">
        <property type="protein sequence ID" value="AGN02007"/>
        <property type="gene ID" value="L593_10310"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2125"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_4_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="24224" checksum="146AE49BD217A38C" modified="2013-07-24" version="1">MLSRINNSNVDANQEDLSNPFGMDEDCENCPGLVEPRSQVVHGYGDVGGDFLFVGERPDAGADESGVPFTNGPAGERLLGILRRCGLCGSPVDSTEPELANVYLTNLTRCRHPERPPTDEEITNCEPFLNAEIRMINPEILVPVGERALEWLVEDYTTTDPDDVSLPDAHGERLRGRGFELVPMVDPATMTDEQADDFVHDFSALMATDYRQTKGRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W636</accession>
    <name>R4W636_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_00940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
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</entry>
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                <person name="Patrushev M.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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    <sequence length="135" mass="14578" checksum="E4A359AABF7FEF08" modified="2013-07-24" version="1">MNDDLSTDGTTEPAQPPLAATRYESGAITYPGHSIGPEGTEPAEEIDLADYTAEVVTWTTSTATPPGVRQPNHLAIVEFDVDGESVRALGQLTTDEVESGDEVRPVYVEELREPGVGIKDAESAQDWDGYRFEPI</sequence>
</entry>
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            <dbReference type="EMBL" id="AGN02142.1"/>
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    <sequence length="245" mass="25976" checksum="8E37B6F2DB01F30E" modified="2013-07-24" version="1">MSAPAASVGIANAGSPWIAVAFDGDGFVEAVVAEEVGALWGRYGETADRIVVGVPTGLVENGAPQRECDRLAREHLGERADAIVTPPSREATRRRRYPAARRVHERTTGGDLSEAAFDLAPAIAAVDELLQEVPESRHVVRGSHPELAFRALTDEPLAHDPATAGGYAERMRILADHDRDGPPTVQSAAEAVAGAAVPIHAVLDALVLAYTARPENGDLRTLPVDPPTDPTGLPMELAYRAERPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W668</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
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            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Harcht-Bsk1</strain>
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    </reference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="127"/>
        </location>
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    <feature type="domain" description="DUF1611" evidence="2">
        <location>
            <begin position="134"/>
            <end position="332"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="Pfam" id="PF07755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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    </evidence>
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            <dbReference type="EMBL" id="AGN00188.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="354" mass="37008" checksum="2AE7DC20E01D9313" modified="2013-07-24" version="1">MRVAILAHEKFPDRAKTAVGICRYGEQDVVAVLDRDRAGDRVADHVPDVQDAPIVESMADAPACDALVIGIAPIGGDFDPSWRSDVRTALERGCDVLAGLHYPLAEDEEFVTLAAEHDCELRDVREPPDDLDVSRGTAGDVDAHVIATVGTDCSTGKLTTTLELVDALRAEGLDAAAVPTGQTGILIEGWGIAVDRAISDYAAGAAERLVENAAAEHDVLVVEGQGSILHPAYSGVTASLLHGAMPDALVLCHEAGREAIHGYEAFAIPPASEVASRYEQFVEPVAPAAVVAGALNTSRIEGEDEAQRAVEEFGAAIDAPATDPVRFEASEVVDGLVPEDEEAAQSGRSGGPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6E5</accession>
    <name>R4W6E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11570"/>
    <dbReference type="EnsemblBacteria" id="AGN02257">
        <property type="protein sequence ID" value="AGN02257"/>
        <property type="gene ID" value="L593_11570"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2385"/>
    <dbReference type="eggNOG" id="arCOG04575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369487_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="22194" checksum="A6FA11F891F96661" modified="2013-07-24" version="1">MADDKRGREAQARQADRRQRDRELREALARADEPEPPEPEPFVEADLDEEIKTADYPMTERELVAAHGTRTVETSSGEEPLENVLLPTPGTYTSPRSVERRIGRPTVASAMRRIDAASKAAGVERMESRRSAYEHTLHELAEIDADDDDEGIEVVTDWIVEQVEETGSLPSSRRVRHRAATFCRSNGYPVPVDSWLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K6</accession>
    <name>R4W6K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02382">
        <property type="protein sequence ID" value="AGN02382"/>
        <property type="gene ID" value="L593_12195"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12195"/>
    <dbReference type="eggNOG" id="ENOG502N61S">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587460_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="465" mass="52927" checksum="4A3E9C02CBA41048" modified="2013-07-24" version="1">MLRAWGEMIAEEPAGPGYSFTPNRQQVFQNRLEAFLENPCEETLEEFWSADAVDSADNPGQAILLAGFEDYQDFASFLETLAAASEYDAAWEDTLTWKWALWELYSRSNTDEPGILTREACEALRWFGVECSGDFAERMDVLEAFRETYFDVVGHATKGTEHEASVRAEMEQLFHAFATLDSGDLSAQLKGPYSEFYRGLYGGSAMDRGRPDPVELVDIGPLAYAYAHGKVNDAYDEPDVSGFFGGYWENWKREYCDYVEETIRDEFTLDDLEAEEIEPLFKALTDREATNLNASVIEYLMGGQWGQYVWNDVEEYFTSNPEEASAVLSEFFDSSKPDVTRLRLFREHTIHIKEEEGRSPGSIERMATSLMMVCEPDEQIGLPPSKTAEFVEAKTTLDDYESGFRPRQYRSVVNALRTFRDEIQSAVEELGGDQSVSMLDVHNVIWMYEDNGEPSNDELPASYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6T6</accession>
    <name>R4W6T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447406.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12865"/>
    <dbReference type="EnsemblBacteria" id="AGN02512">
        <property type="protein sequence ID" value="AGN02512"/>
        <property type="gene ID" value="L593_12865"/>
    </dbReference>
    <dbReference type="GeneID" id="16180216"/>
    <dbReference type="KEGG" id="sali:L593_12865"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129111_0_0_2"/>
    <dbReference type="OrthoDB" id="80908at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="171" mass="19350" checksum="A61B3A5E068778A4" modified="2013-07-24" version="1">MELLPLPTDAAAVELFVEDCWLPYHRELERVVDAHSLDESVDLVAKEVAFRREWLREPDRGLWIAVEGTPEDPDAIAEESADLAGFVAIERQTASPVFDRPDRVVVDDLYVRERHRGTGLARELVDLGVAEADAHDCDEVTLEVDVDNDRAIAFYEKLGFEPYRQTMVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y1</accession>
    <name>R4W6Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NGG1p interacting factor 3 protein, NIF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445527.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03410"/>
    <dbReference type="EnsemblBacteria" id="AGN00633">
        <property type="protein sequence ID" value="AGN00633"/>
        <property type="gene ID" value="L593_03410"/>
    </dbReference>
    <dbReference type="GeneID" id="16180533"/>
    <dbReference type="KEGG" id="sali:L593_03410"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.690"/>
    <dbReference type="eggNOG" id="arCOG04454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_3_0_2"/>
    <dbReference type="OrthoDB" id="40682at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="255" mass="27021" checksum="B363654463EC4EAB" modified="2013-07-24" version="1">MQRSEFVSRLDERLRTEDYADVDASPNGLQVGSAEGEVERVAFAVDAAVATIEAAIERDADLLVTHHGIVWGSIERVTGTAHDRIAPLLRNDVGLYVSHLPLDGHPDLGNGARLADLLDLGNRAPFGELGPEYVGQQGVLPEPTALDDLSATLYEDLPTGDGSVQVLDHGPGTVSDVAIVTGSGSDWLDEAAAEDVDVLLTGEGKQKVYHEAREAGVNVILAGHYATETGGVRALRSLAEEWGLATTYIEHPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W725</accession>
    <name>R4W725_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447551.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13590"/>
    <dbReference type="EnsemblBacteria" id="AGN02657">
        <property type="protein sequence ID" value="AGN02657"/>
        <property type="gene ID" value="L593_13590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180712"/>
    <dbReference type="KEGG" id="sali:L593_13590"/>
    <dbReference type="eggNOG" id="arCOG06117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665573_0_0_2"/>
    <dbReference type="OrthoDB" id="99975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="16926" checksum="6A0E0764DBD08558" modified="2013-07-24" version="1">MNQDLTSRGGRDRGQTAQDFAVGIGLFLLAVAFVFAFVPQVVSPYDVGVGASESAQADRAASLIVGNLSVEDRPNELHASRTTTYFNGADVDALRNRTGLPFTARINVTVRNVASDDLVWSGGAMHREGRATAAATRIVRTNEPGTCDPACRMTVRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W737</accession>
    <name>R4W737_9EURY</name>
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        <submittedName>
            <fullName evidence="6">GAF/PAS/PAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03760"/>
    <dbReference type="EnsemblBacteria" id="AGN00703">
        <property type="protein sequence ID" value="AGN00703"/>
        <property type="gene ID" value="L593_03760"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.763"/>
    <dbReference type="eggNOG" id="arCOG02278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381143_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="726" mass="77643" checksum="653841ED311C22A8" modified="2013-07-24" version="1">MARRQEPGALGFAGMMAAETVWSGTYVVALLVHDPAARTVLENVKWFGTCVYLFLLLFALEYTGHDEFATRRILGLLSLPWIASVGLIWTQQWHDLWWSTSLMEIHGLAILQFSYGPGFLAHTLYSYVIILLASALLLRLVFVSDYLYADQSALLVFGILAPVGFNVADIALLEPGAVVDLTPVAFTVSGLAFGYALFRHRLFDLVPATRRLGRNAAIGQLETGIVIVDTAHRVVYCNAAAEPVLGREPADALDEPLRSLVDVDEVDFDAPDGLAEIERDGTVYEVRTSPITDRHDRTIGHTLVAHDVTARKRRERALAAQRDELETLSALNVLIRGVVQALVSENERDGIERAVCDRIVEGDLYHTACVGDVQTWNGEAERWTVAGSSSGADAPSVDTEKLDVTEGPTVEGGADVDRPAASGAGTTSVSDGAGSAGAHLPAVSEDAHTWVVVPIVYGRTVFGAIGLATDRDTVSARERSVLGELGEAVGHAMNAVSTRQLLSTEAVVEVEFESTTDADALVAATAGTDCELELAGVVPAGDRSTLAYVRVDGDVTAAENALADATEGEVRSIRGDDSGGLLEWRVSGADLLGAVVDQGAQLRSFEASDGRVDYRAEVASDDAVRSLLDSLDGRFGGVRLLAKRERASSIEDSAALPADGIDDLTDRQQEAIEAAYRAGYFDWPRESTAEEVASAMEIAPSTLHSHLRKAEGTLLASLFESGPDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C9</accession>
    <name>R4W7C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_14465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14465"/>
    <dbReference type="EnsemblBacteria" id="AGN02832">
        <property type="protein sequence ID" value="AGN02832"/>
        <property type="gene ID" value="L593_14465"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2958"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="31897" checksum="72A9B681D9B075A7" modified="2013-07-24" version="1">MSKRYGSVTALDRVDLTVEAGEIFGFLGQNGAGKSTMINILLDFVRPTQGQVEIFGHDCHRESVSARRRMGVLPEGYDVYDRLTARQHIRFAMESKDADGDPMELLDRVGIADAADRQAGGFSKGMAQRLVLGMALVGDPDLLLLDEPTSGLDPNGAVTLREIIREENERGTTVFFSSHILEQVEAVCDRVGILHEGALVAIDTVEGLRSSAGGGTKLSITVADLDVVDLGVVEGIEGVESAWLEAAEDRVDVTCSNDAKMDVLVALDDVGVDVVNFETEEPSLEDLFVEYTGGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7P9</accession>
    <name>R4W7P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05770"/>
    <dbReference type="EnsemblBacteria" id="AGN01103">
        <property type="protein sequence ID" value="AGN01103"/>
        <property type="gene ID" value="L593_05770"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1181"/>
    <dbReference type="eggNOG" id="arCOG07870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="443" mass="47242" checksum="4EBE72ACC3C693FA" modified="2013-07-24" version="1">MNDVARRGWATAAAVFETARNAQLTFLAAAIAYYAFVSIVPLLALVVVLSTAIGGEALVQEALDRTDTVLTDQTQELLFNALLNQQGRIGATAFGTVAVSWSALRVFRGLDIAFSEIYGSAEEATFLSTVRDGLTVTVAIFVGLIAMTGIVFGVGLLPLGPFAPLVAVLLGVLTLTVLFLPMYYVFPDRPIDVGEAAPGAVTAALGWMLLAAGFSVYVDVATGVTVYGVLGGVFLLVTFLYFGALIVVVGAVVNVTLGSDRQLQQGSSPGPGLTRTMPASKDDTPADEEASPESGGADGEDDATQEAVGPEAAEFDPGERTPEEARLREEVAELRAELDDFRDDVEGRTVDRDEVEGDLKRYVRRRVRRGHARGWGPYLVLLYGTAMTIGAFYYLSSGWAILAMFVVWLSTLGLYVLMVLVGAGLSLLGLPGRLRDRIGEWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S7</accession>
    <name>R4W7S7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06095"/>
    <dbReference type="EnsemblBacteria" id="AGN01168">
        <property type="protein sequence ID" value="AGN01168"/>
        <property type="gene ID" value="L593_06095"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06095"/>
    <dbReference type="eggNOG" id="arCOG03726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891518_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="134" mass="14851" checksum="6DA1A8E316A52CF9" modified="2013-07-24" version="1">MPALDLYDGYFFRIIKKALRADQFQPGLDMIIISAEHGVVETDDKIGYYDRQMDTDRANELNDEVVGEIAEKVAGNEYDKVWVNLGADYLPAVDGIEAAVDIPVHYIEGCGIGMKGKRLKHLVSSGRPDPVHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T7</accession>
    <name>R4W7T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444948.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00495"/>
    <dbReference type="EnsemblBacteria" id="AGN00054">
        <property type="protein sequence ID" value="AGN00054"/>
        <property type="gene ID" value="L593_00495"/>
    </dbReference>
    <dbReference type="GeneID" id="16181694"/>
    <dbReference type="KEGG" id="sali:L593_00495"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.101"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="OrthoDB" id="84020at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="25536" checksum="ECD137B4FA8A6585" modified="2013-07-24" version="1">MHLAEATWPDAEAAETPLALLPVGSTEQHGPHAPLSTDTIAAEAVAAAGAERFDERVVVAPAIPVGVSEEHRHFGGTMWVSEDTFRAYVREAATSLAHHGFDRIVLVNGHGGNVDALREVAARLSRDGDAYAVPFTWFDSVDAPDMGHAGPVETSLLRHVAPELIKDDRIEEAVAGASDGWGEWVAGVNLAFDSAEFTDSGVVGDPSQADEQRGEALLDAAAAALASLLDAVADREPSAEFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y8</accession>
    <name>R4W7Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propanoyl-CoA C-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445068.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01105"/>
    <dbReference type="EnsemblBacteria" id="AGN00174">
        <property type="protein sequence ID" value="AGN00174"/>
        <property type="gene ID" value="L593_01105"/>
    </dbReference>
    <dbReference type="GeneID" id="16182381"/>
    <dbReference type="KEGG" id="sali:L593_01105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.226"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="254"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="388" mass="40971" checksum="6AD5B5766A52A812" modified="2013-07-24" version="1">MDERVAVVGASMTKFGERDAWIQELLAQAGKECLEDAGVDPGDVEHVYTSNMSSGEFEGQTGIMNALAHDLGLMPAYSQRIDQTSSSGGAGIYAAWQSVASGASDMTLLVGGEKMTHRTTGEATDVIASITHPAEYKHGVTLPSFAGMTARHYLEKYDAPRESLAKVAVKNHKNGVDNPHAQFQKEVDLETVLESPIVADPLRLYDFCPITDGSAALMLCPESVAAEYTDEYAVISGVAGATDTHVVHERDDPTTMGGVVDSSDAAYEMAGLDPDDVDVAELHDMFTILEFLQMEGLGFTEPGEAWKHVEEGRTEKDGALPINTSGGLKSKGHPLGASGVAQGVEIYEQLVGEAGPRQVEADVGLACNVGGFGNCVITTIMESGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W808</accession>
    <name>R4W808_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ileS</name>
        <name evidence="11" type="ORF">L593_07280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446297.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07280"/>
    <dbReference type="EnsemblBacteria" id="AGN01403">
        <property type="protein sequence ID" value="AGN01403"/>
        <property type="gene ID" value="L593_07280"/>
    </dbReference>
    <dbReference type="GeneID" id="16180584"/>
    <dbReference type="KEGG" id="sali:L593_07280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1486"/>
    <dbReference type="eggNOG" id="arCOG00807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="716"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="623"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123253" checksum="41FAFA050AEBD2D5" modified="2013-07-24" version="1">MSDAEDLSDQYDPHAVEDRVADRWDERNAYERTVEHRADGEDFFFVDGPPYTSGAAHMGTTWNKTLKDAYIRYLRMSGYDVTDRPGYDMHGLPIETKVEEKLDFENKKDIENFGEEAFIEECKAFAEEQLDGLQEDFQSFGVWMDWDDPYKTVDPEYMEAAWWGFSRANERGLVEQGQRSISQCPRCETAIANNEVEYEQVEDPSIYVKFDLSDREGSLVIWTTTPWTIPANTFVAVDPEVEYAAVDATKDGEEERLYVAEDCVEEVLKEGRYDDYEVAKTLSGEDMLGWEYEHPLDDEVPDHPSGEDALQVYAADYVEVDRTGLVHSAPGHGEEDFERGRELGLDIFCPVGGDGVYGSAAGEYAGEFVKDADADIVADLQDDGALLAHGTTTHSYGHCWRCDTGILQIVTDQWFITITDIKDELLDNIEDSEWHPQWARDNRFRDFVEEAPDWNVSRQRYWGIPIPIWLPSEARSASDESSGQSPRDGGDDWNGSMDDAIVIGDREELAERVDQDVDPETVDLHKGTVDDLTITENGTTYERVPDVFDVWLDSSVATWGTIGYPSNTEAFEELWPADLIMEAHDQTRGWFWSQLGMGTAALGEIPYEEVLMHGYANMPDGRGMSKSKGITVEPGEVIEKHGADPMRMFLLSVNPQGEDMRFSWEGTETMQRDLNILWNVFRFPLPYMELDGYDPASYDLDALADLDEQGALTTIDRWLLARLQSTAADAQAAWDDFRQDEAVEAVREFVVEDLSRFYVQVVRERMWDEADSPEKQAAYETLTYALHQVVAMLAPFAPYLTDEIYDQLTGDEGHPTVHMLDYPEPAERWVDEQLEADLDVLREVEEAGSNARQQAERKLRWPVSRVVVAPDDAAVYDAIDRHRNLLADRLNAREIELLDAETEWGELQYSADADMGELGPAFGDRAHEVMTALNEARVEEPTVDAFADALVAGDVLESADELTEAMIDPVTESPDDVSGTPIVDEGEELGVVYVDTTLDDDIESEGYAREVIRRVQEMRKEMELDVEEPIRLEYAIADDRVADLVADHDDLIAEEVRADSTGVVEDGHRKEWEVEGVTVEIAIAPLAAGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W839</accession>
    <name>R4W839_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445178.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01655"/>
    <dbReference type="EnsemblBacteria" id="AGN00284">
        <property type="protein sequence ID" value="AGN00284"/>
        <property type="gene ID" value="L593_01655"/>
    </dbReference>
    <dbReference type="GeneID" id="16179900"/>
    <dbReference type="KEGG" id="sali:L593_01655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.336"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="30723" checksum="EF06C58B623526C6" modified="2013-07-24" version="1">MSEQLPAAADCPTIDGVPALGIGTWENEDPEQCAESVRTALEAGYRHVDTAQIYGNEEAVGNGIAAANVDREDIFLATKVWIDNLDHDDVIATTEESLEKLGVDRVDLLYVHWPARAYDPEDSLSAFAELRERGLIDHVGVSNFLPEQVDRAIEVSEAPIVANQVELHPYLPQYDLVEHCQDRDVTVVGYSPLARGNVLDDDTIGAIAEKHGVSEAQVSLAWLRQRDVVTIPKATSAEHVHDNWKSLDLTLDDEDVEQIESIEHRERQVDPSFGPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W856</accession>
    <name>R4W856_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease J</fullName>
            <shortName evidence="4">RNase J</shortName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rnj</name>
        <name evidence="6" type="ORF">L593_01915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445228.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01915"/>
    <dbReference type="EnsemblBacteria" id="AGN00334">
        <property type="protein sequence ID" value="AGN00334"/>
        <property type="gene ID" value="L593_01915"/>
    </dbReference>
    <dbReference type="GeneID" id="16179985"/>
    <dbReference type="KEGG" id="sali:L593_01915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.390"/>
    <dbReference type="eggNOG" id="arCOG00546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_4_1_2"/>
    <dbReference type="OrthoDB" id="12384at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01492">
        <property type="entry name" value="RNase_J_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030879">
        <property type="entry name" value="RNase_J_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="386"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        </ligand>
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        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="86"/>
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        <ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="412"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00849"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="449" mass="49996" checksum="B48BCF12E58D062A" modified="2013-07-24" version="1">MEIEIATIGGYQEVGRQMTAVRAGDDVVIFDMGLNLSKVLIHDNVETERMHSLDLIDMGAIPDDRIMSDLEGDVQAIVPTHGHLDHIGAISKLAHRYDAPVVATPFTIELVKQQIESEQKFGVENDLVKMDAGGTMSIGDSGVELEFVNVTHSIIDAINPVLHTPEGSIVYGLDKRMDHTPVIGDPIDMKRFREIGREDNGVLCYIEDCTNAGKKGRTPSESVARKHLKDALYSMEDYDGGIVATTFSSHISRVTSLVEFAKDIGRQPVLLGRSMEKYSGTAERLDFVDFPEDLGMFGHRKSVDRTFKRIMNEGKEDYLPVVTGHQGEPRAMLTRMARGETPYELDAGDKVVFSARVIPEPTNEGQRYQAEKLLGMQGARIYDDIHVSGHLNKEGHYEMLDALQPQNVIPAHQDLSGFSDYVNLCEDEGYRMDRDLHISRNGNLIQLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W892</accession>
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        <lineage>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
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    </feature>
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        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AGN01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="37980" checksum="4475DCA13DC3E97B" modified="2013-07-24" version="1">MRADLPRNEYAADSPDAEVAAMTSEFTEITVIGDDDTGLIARTTTLLFEHGINIEDLDQAVREGLFRMSMTVDTSEMECTKDELRADLAELGDDLGVEVQVRFPSERATRRIAVLVTQESHCLEALLDAWANDELGAEVSVVIGNHDDLEPLAASHGVPFHDVGGESGQPDEDELLDLLAEYDVDLIVLARYMRILSPKVVFRYEDRIINIHPSLLPAFPGARAYEQARQEGVRVGGVTAHYVTTDLDQGPIITQRVFDVPDGASTDELERRGQPLEAEALLEAVRLHLEGEVHVHRGRTHLRDEADPEGYQLGLSPEARRANPDRPLDGLGDAVRSEEAEGSSD</sequence>
</entry>
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    <accession>R4W8B4</accession>
    <name>R4W8B4_9EURY</name>
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        <name evidence="2" type="ORF">L593_08440</name>
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    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UCP022062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="183" mass="19552" checksum="45A87858AF766641" modified="2013-07-24" version="1">MRLVEGYADVEDLDAFLESLTAIGEEHGCVVQAFDARYVASRGHLDHALRTARRAIDRGEAIARDPAVEVLCYAAGTRQIEVALKLGVAEGRTPVVVLVARLDDDIDADGVSGSEGDVRAAETAAADAVRDLIEPADLKRGAELGDPERLRSFFGIDEAELAASDADLATLVRERVALLAVER</sequence>
</entry>
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    <accession>R4W8E3</accession>
    <name>R4W8E3_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
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    </gene>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00584">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="28478" checksum="72A7C4E8A73A28A5" modified="2013-07-24" version="1">MSDTGGQSRRASSGSPSRSAARFHGSDQQRLAQDADDATRFYDRWASLYDLLATYAPFVGRLRRRAIDALCLERGDTVLEIGCGTGANLQLLAREVGPRGTVIGVDRSRGVLERARRNARGYPQVEVLRADGTQLPLAAPGSETGPEDPGLDGVLATFVVGMLEEPAASVDQWIDHLGPDGHVALLHLRRSEHAFAPLANSALSVATILSTPPTTKLRYERDLSHALDARVRAAGDVVHERTDPTLTESHLFDLVELTAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I1</accession>
    <name>R4W8I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03565</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445558.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03565"/>
    <dbReference type="EnsemblBacteria" id="AGN00664">
        <property type="protein sequence ID" value="AGN00664"/>
        <property type="gene ID" value="L593_03565"/>
    </dbReference>
    <dbReference type="GeneID" id="16180646"/>
    <dbReference type="KEGG" id="sali:L593_03565"/>
    <dbReference type="eggNOG" id="arCOG08148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084196_0_0_2"/>
    <dbReference type="OrthoDB" id="113206at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="24722" checksum="DF2ED7E0BF455DEE" modified="2013-07-24" version="1">MGAVGRQRAAVAAGIRSTLREPTTVVLLLALPPLVVAVFDVALATYGAAPGIEVGATEAERGGALFSTAFLAGLLGVFQIVGAAEADGRLVVCGYRPAEVVGARLVAIGLASLLVTGITYATFAWMSPEAIAAPGLAILALFLAATTYALVGVIVGTVIGRELEGSLLLVFVADFDSFTSLGVIPTESELLEYTPLERPARLLADAVTRGTIQTGDLLGAIAYLVVLLGIAVAVVEFRGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I7</accession>
    <name>R4W8I7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09365"/>
    <dbReference type="EnsemblBacteria" id="AGN01818">
        <property type="protein sequence ID" value="AGN01818"/>
        <property type="gene ID" value="L593_09365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09365"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1926"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="31776" checksum="509EBC5B63A0ECFB" modified="2013-07-24" version="1">MPDDSRREDAAERDGDEGRDPGTVLITGCSSGIGRATALAFLEDDWTVYATARDTDDIAELAEAGCAIDELDVTKQADVQRVVGRIMEEDGRIDALVNNAGYGLFGPIEEIPTEAMGHQFDVNVFGPHRLIREVLPYMRRQQRGAIVNVSSFWGRVSYGGGGAYAASKHALEAMSESLRQEVDAFGIEVSVVEPGPVDTQFTDRAEDELDELQPTGEYEWFESAFEDLSAIGGSGPAAVSPAEVAEAIHHAASCDDPEPRYPVGVPGSVAMLGRFLPARWRDRVFSLVRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J9</accession>
    <name>R4W8J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446757.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01863">
        <property type="protein sequence ID" value="AGN01863"/>
        <property type="gene ID" value="L593_09590"/>
    </dbReference>
    <dbReference type="GeneID" id="16182761"/>
    <dbReference type="KEGG" id="sali:L593_09590"/>
    <dbReference type="HOGENOM" id="CLU_1943943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="13461" checksum="8C3E696116213595" modified="2013-07-24" version="1">MLRRLLAAVAGIGLAAGVSFGLFQVVPLRYALAVGAGLGAGVFLVVDGSAGAGEGWVYHQVRPVEARIRDFLWAAGLGTALGLTLAWVTVVVELGRIGAGILVVVGSVLLANLVFLYRRPKYEEALEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K5</accession>
    <name>R4W8K5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_09715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446782.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09715"/>
    <dbReference type="EnsemblBacteria" id="AGN01888">
        <property type="protein sequence ID" value="AGN01888"/>
        <property type="gene ID" value="L593_09715"/>
    </dbReference>
    <dbReference type="GeneID" id="16180004"/>
    <dbReference type="KEGG" id="sali:L593_09715"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2000"/>
    <dbReference type="eggNOG" id="arCOG01044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_1_2"/>
    <dbReference type="OrthoDB" id="94240at2157"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="25824" checksum="06A7EDBA5C6F0017" modified="2013-07-24" version="1">MIPLAHDFTNETVLIFGGGSVGARKARHFAVEADVVVVSPAFVDADFGDSDRIKAVPAPDDLGEWVARFDPALVVAATDDESVNDAAASAARTHGALVNRADRSAVDHAIDASDDATDASDGAADDSAADRETDASDGDRTLDDVAVPATLRDEPVTVSISTGGTSPALARVLRQRVESEVDGAGAMAELTGDLRERLRAEGVDPDARRDAVRAVVRSPRVWTALRSGDSKLEEITGELLAEVLDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M1</accession>
    <name>R4W8M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding ferritin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00734.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ferric iron binding"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="20458" checksum="E2699B4D2D4E26D0" modified="2013-07-24" version="1">MSTQKTVRQEAGTVEGSDALRMPADKAEEIVEALQTDLADTYVLYHQLKKHHWIVEGAEFLDLHLFLGEAAEDAEEAADVLAERVQALGGVPHSGGATFEEHATIEPEDEDAYDIRTSLEHDMECYGDVIESLREHIALANNLGDYTTEEELREILEETEEHAHHIEHYLEDDTLVFEGAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R0</accession>
    <name>R4W8R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446907.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02013">
        <property type="protein sequence ID" value="AGN02013"/>
        <property type="gene ID" value="L593_10340"/>
    </dbReference>
    <dbReference type="GeneID" id="16182180"/>
    <dbReference type="KEGG" id="sali:L593_10340"/>
    <dbReference type="eggNOG" id="arCOG06330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700346_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="16113" checksum="427DEFD6FAE0AD0F" modified="2013-07-24" version="1">MPRRPGGVLRRDLLATLLALLPASAARSAFEGIQNLALEDDSDGEGDGRSRSDDSGDSRRDDAPGTAVVDRIEDDTAVVLFEDGRGQETVSTAVLPAAAREEGVVLRVPRGDSLALATVDRTATAARRRNASDRFDDLAKPGPESGMATNATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R3</accession>
    <name>R4W8R3_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00854">
        <property type="protein sequence ID" value="AGN00854"/>
        <property type="gene ID" value="L593_04515"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.920"/>
    <dbReference type="eggNOG" id="arCOG02327">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="345"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="559" mass="58812" checksum="AD37D033F3B4C6E5" modified="2013-07-24" version="1">MAWLLAGVAILGGSLTLSVALDPTRSRPATVALSVLVVLLGAIAGVLALLAANVGGIRADPTVQLALLGGYAFASLCWIAFATEYTGTAPTTTRRWVGALALLGVLAVGSSAITWLHDAGRRDFGVLGTVSYLSSSVLQIAVFALGLLGVVLLARSTLRYDDLPAWRGATLSLGGLGVALLPFTIPLGQQLSTTATLAIGLGQVGVTVGVLGLGELRGELLAPAPAAGHLARETVLAALDHPVVVTDHRQRVLDANRSATRTFDLPRSNLRRGTLSELTGLDVDDPDRTIATPVTLRTTGGRRQFEVRRTDIDGDEGRPAGAVYLFQDVTDRRTREQQLQVLNRVLRHTLRNDLDAIRGFAEPVREGALDRDVAVEQLDRIEGLATDLVDLAETVEHSGRLLTAEQLDPADCDLEAIAGSVLEAVDADVSLTRSQSAPVVHSDPEIVRLVVAELVENAVEHSDRDSPTVSVAVTGTADGATLTVRDDGPGIPEYEQRILLGGEETPAAHGSGVGLWLVHWAVTRLGGRLEFGDNDPRGTVVTVSLPDLSDAPDASGEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V5</accession>
    <name>R4W8V5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_10865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447012.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10865"/>
    <dbReference type="EnsemblBacteria" id="AGN02118">
        <property type="protein sequence ID" value="AGN02118"/>
        <property type="gene ID" value="L593_10865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182050"/>
    <dbReference type="KEGG" id="sali:L593_10865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2242"/>
    <dbReference type="eggNOG" id="arCOG00797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030778_0_0_2"/>
    <dbReference type="OrthoDB" id="41107at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="612" mass="69077" checksum="F56B0EE8490BEAA1" modified="2013-07-24" version="1">MSQSDTDVVRLFGGPGSGKTTALLDRVEEILEADDVDVNDVLVVSYTRAAAAEIRERLAERLDVTPRSLQGNVCTMHAKAYELLNLSRGDVVGESDKEEFCDDYGIEFEDEHSGAGRRTARSTTIGNKIIATSQWLQRTRRDVADWYDVPFQWDEEEVRLPPDIDPNAQEGNKYTPTWPTSDDRIDVPEAIRGWRSYKGEHDLTGFADMLERVKQRSLQPGVDYLIIDEFQDITTLQYEVYEEWKPHVERVLIAGDDDQVVYSWQGADPALLLDEDVDEDVVLPNSYRLPSRVLNAVNREISHIDVRQEKDLEPRIEGGAVEAIDSPSMLDLVREVRRTVETDDGSLMLLFRARYQMFRFIDEFIGEGIPFGVMTDQRMWTDRLNQFVDGIEAIDAGEPLSALEARRLADMLADSAFGSNERDDLFDAIDEREEESELDDLAEIQVEPEFVTDHVPFMPGPASAADMSRKITSFQTESMKSYFGGDYQDVARDRVRVGTIHSAKGREADHVFLGTDLTEKVVEQMAATVEDPTDVEGCDEFTKTTNPVPVLTDNERRVFYVGMSRARERLVIMENLVGGAPTLPIDVLLTNGPSERDVEELLDEAKEPVQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y5</accession>
    <name>R4W8Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05475"/>
    <dbReference type="EnsemblBacteria" id="AGN01044">
        <property type="protein sequence ID" value="AGN01044"/>
        <property type="gene ID" value="L593_05475"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05475"/>
    <dbReference type="HOGENOM" id="CLU_2044509_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13712" checksum="E9DDBF646BDDCACE" modified="2013-07-24" version="1">MDGPKERDRVAVRFDPDDRPHPERHPADHEDDAVDESEADGDADGIEVEAERRDADREDRPRADAVQEVQEHAGHRVVLGIAAGELCHECCRRRRAAVAHRHHHHRHDDRRDETACQTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W921</accession>
    <name>R4W921_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447177.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02283">
        <property type="protein sequence ID" value="AGN02283"/>
        <property type="gene ID" value="L593_11700"/>
    </dbReference>
    <dbReference type="GeneID" id="16181716"/>
    <dbReference type="KEGG" id="sali:L593_11700"/>
    <dbReference type="eggNOG" id="arCOG07683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807997_0_0_2"/>
    <dbReference type="OrthoDB" id="58561at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="40994" checksum="E0F919F79B4F8946" modified="2013-07-24" version="1">MIFSVDQDTDELQYLSGQDFAQLDILEREHLEEWAIEEPRILGEELLVIASEYAKFQDLRERLDILALDLEGKLVTIELKRDKADRTTDLQAIKYASYCATLTAEDVQKDYRNFWNERNGTDLTPEDVGEEFVDFLPQDVLDEVSYTDEGWANFELDDRPRILLVAGSFGPEITSPAMWLREEYNMDITCTRIEAYKHRDRVILNSQQVIPIPEAEEYLTKRREKEEKQKKTSVTYTLPALLDRGVLTEGDIVVFQESKVPADSSKEWDPESDYWRARITGETGQQDNVEWLENGEIYSFTGLTREILNRLVDRDKDKPLNGYSYWIHPEFGGRTLLELRQENVKGEDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W929</accession>
    <name>R4W929_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11825"/>
    <dbReference type="EnsemblBacteria" id="AGN02308">
        <property type="protein sequence ID" value="AGN02308"/>
        <property type="gene ID" value="L593_11825"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11825"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="79"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="303"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="829" mass="90614" checksum="B1FB034A10AE7EB8" modified="2013-07-24" version="1">MTEYDGSDADRRNGGWSEHAEILDPAHFEARFPDYDDQIVHTRTQPAESAETVPAADVLPSDLADRLGHDLYAHQADAIERLRDGENVAVATPTASGKTLVYALYVALRKRADPDARAIVCYPTKALARDQRASIADLYRRLGLDFEVAVYDGDTPGHRRPEIRENADVVMTNAAGLNVYLAHHTQWRECFGNCALLVIDEAHAASGIHGMHVAWVLRRLRRVLDFYDADPRIVCTSATIGNPAEHALRLTGEEHAVVDADGSPHGRREIAFWKPPLEDDLGEDYGMDEYLGAVKRAGAATGEIVAHLGLHGVQTLAFSRSRQGTELTAKGAERAASDHPAGGGSGAGSGYLSVAPYHAGHGKQTRRQIEERLQSGDLDAVISTSALELGIDVGSVDATVLSGYPGSRQSFWQRLGRSGRGTEDALSVLVGRADAIDQYVLDHPEFLFEDDVEDAVIDLGNDAVYARHLLAAANELPIDRDDERWFGASALPAGEVQDADDRLDRAVSMWQEAGVLVGDLDREVRYDGPPRPEADVSMYATDSETFLVECADGEIDVAPIGKDRAYREYHPGAVVIHDGTEYEVVEFEEDLPQPRVTLAEIEEDVYTRTHSTKSVSDVEERTSRDLGDGWHLKFGVGTVSVHYAHYERRDVQSGDLVGPIQETGLGPIELRTQLTWVEAPKSLRETALEDVPPEDLLAEPAQYGRGQRQYTFLGGLHGAEHAMIELAPLELRLDSSEIGGLSIDPHPETGVPTWFIHDGVDGGIGYARGIYEHADSLVARTREHVDTCGCDGVRGCPACLMDVQCGNRNEPLHRPATIAILSELEERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W930</accession>
    <name>R4W930_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446043.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06000"/>
    <dbReference type="EnsemblBacteria" id="AGN01149">
        <property type="protein sequence ID" value="AGN01149"/>
        <property type="gene ID" value="L593_06000"/>
    </dbReference>
    <dbReference type="GeneID" id="16181810"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="47"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="205" mass="22924" checksum="F0C17362F49CC331" modified="2013-07-24" version="1">MSLYRPRARPKASVYDAAYTGAPNWDIGRPQSAFVRLEEAGLIEDPVLDAGCGTGELACFLARRGHRVLGVDLSTLAVRQAREKARWRRIDARFLVWDALQLERLATAGFSFRTVVDSGLFHVLGPAERDRLADGLAAVLEPGGLYAVLGDARHPDREFYGVTPGEFADRFPERSGWERIFAVETTFERRWGGSPAFFVGLRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W960</accession>
    <name>R4W960_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447307.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02413">
        <property type="protein sequence ID" value="AGN02413"/>
        <property type="gene ID" value="L593_12370"/>
    </dbReference>
    <dbReference type="GeneID" id="16179892"/>
    <dbReference type="KEGG" id="sali:L593_12370"/>
    <dbReference type="eggNOG" id="arCOG10769">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182717_0_0_2"/>
    <dbReference type="OrthoDB" id="122862at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9128" checksum="E6C5A538067471A4" modified="2013-07-24" version="1">MRSKEDVTLAASLRHAPVRTGLVAVVPVVLGIVQLLNGLFTNLSVLVGVAFAAMMIASAVVFTRHHLAQLRLEVLETRVHTQSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W966</accession>
    <name>R4W966_9EURY</name>
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        <submittedName>
            <fullName evidence="6">Integrase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06310"/>
    <dbReference type="EnsemblBacteria" id="AGN01209">
        <property type="protein sequence ID" value="AGN01209"/>
        <property type="gene ID" value="L593_06310"/>
    </dbReference>
    <dbReference type="GeneID" id="16181697"/>
    <dbReference type="KEGG" id="sali:L593_06310"/>
    <dbReference type="eggNOG" id="arCOG01250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="29412at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
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        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="118"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="41501" checksum="227995BEEBC1A3DB" modified="2013-07-24" version="1">MTMDTLDPISPQDALDWYLEHREDDLRTATLRKYESALSIFVDWTDEADIDDMNDVKGRQLMQFKTWRKQEAGLATVSLNGNLAILQRFLRFCENIDAVPEGLAERVPMPNVPEAEEVNYEVPSDEEVEGIKSYSRQFDRASRRHLEFELIAEVGMRLGAVRGMDLEDFDPEEKTIYIRDRPEGTDEYGTPLKNDAKGERIVNVSPELRNLIVAYIDHRRIDVTDQYGREPLFTTSDGRPTKATIRRDFYKMSRPCVYSNECPHDRDIDDCDAATNSKAAECPSRFSTHPLRKWAIMNQLDEGISKELLSDRVDVSVPVLDKHYDHRTEEQKSRRRLEVLEENMQQYAVTDGGQTVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W971</accession>
    <name>R4W971_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447337.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02443">
        <property type="protein sequence ID" value="AGN02443"/>
        <property type="gene ID" value="L593_12520"/>
    </dbReference>
    <dbReference type="GeneID" id="16179896"/>
    <dbReference type="KEGG" id="sali:L593_12520"/>
    <dbReference type="eggNOG" id="arCOG06167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076271_0_0_2"/>
    <dbReference type="OrthoDB" id="59948at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="33116" checksum="EC0DB9DB62FC58D7" modified="2013-07-24" version="1">MSQVGGSRHAIDPPTIESTCSGIACEANSMLTVLVVLGALTLGTVAFLSCVRRARSAVSFERERLLDEYEAFLAFADRVANIPVAPRPDGGRPMGPLVSKAPEDSGLVQVRDAYRDTVMDVPHFDTDYDESMKEHMSTELSPELASAVVEGSQFTPAIRNPLVASAKSAAHDRRVLADQLDDERSDLEDAEDRLTDLSQRFEVTGGEGLVDRTFPDLQARWDRLNGLQDDCSAMLARRQAQLRDRTPSSGTRLQSPTAVSDYLYADLDVDFPVLSAGTRLMERIEEEKRQTVEALTERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W975</accession>
    <name>R4W975_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446128.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06435"/>
    <dbReference type="EnsemblBacteria" id="AGN01234">
        <property type="protein sequence ID" value="AGN01234"/>
        <property type="gene ID" value="L593_06435"/>
    </dbReference>
    <dbReference type="GeneID" id="16181736"/>
    <dbReference type="KEGG" id="sali:L593_06435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1311"/>
    <dbReference type="eggNOG" id="arCOG00505">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061385_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="32323" checksum="57FCE47B3B57D082" modified="2013-07-24" version="1">MVEPVAVSPETYVVDTHEMGIPERTAAYVVDDEQPTIVDTGLSTGAPHILDALDEIGLDPADVEYVALTHIHMDHAGGAAEIVEACANATVLCHEYGVDFISDPEVVPKLVEGVHEAVGDLANDYGTMRPIPRDRIRVLEGGETIDLGARSLEVVHAPGHAPHQVAYYDGDNGCLFPGDECGEYVDDTVVPSTPPPDFDPDAIEESLDGFADSELDAIYFPHYGEHTAPQQAIAEYRTVLDEWVEAVAELHERHDDTAAIVDALLEDHLYADLYEERVAWELVRLNVDGVLTYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W992</accession>
    <name>R4W992_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06685"/>
    <dbReference type="EnsemblBacteria" id="AGN01284">
        <property type="protein sequence ID" value="AGN01284"/>
        <property type="gene ID" value="L593_06685"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1365"/>
    <dbReference type="eggNOG" id="arCOG01267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OrthoDB" id="55074at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="29950" checksum="4DC25BEFBD97E848" modified="2013-07-24" version="1">MSPEVSPPELAREDVHTIDDERFVRDRVAVVTGAASGIGRATALAAAVNGLSVLATDVDEEGLAATVERAEAIGEPADAIEPFAADLQDEVEIEAIADAARDLGDVTFLANVAGLQHVAPIGEFPTPAYDRIQNVMLRAPILLTRELWDALEENDGCVGNMASVHGHYVTSDKVAYNVVKFGIRGLTQSIAAEGDGDLRSFSVSTGYVETPLVTNQLADTAEQRGISVDEVIEDVMLGQARSKEMMTPAEVGNLFVLGFSHLAQHLNGGDLLFDGGMTLTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F4</accession>
    <name>R4W9F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446353.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07570"/>
    <dbReference type="EnsemblBacteria" id="AGN01459">
        <property type="protein sequence ID" value="AGN01459"/>
        <property type="gene ID" value="L593_07570"/>
    </dbReference>
    <dbReference type="GeneID" id="16182153"/>
    <dbReference type="KEGG" id="sali:L593_07570"/>
    <dbReference type="eggNOG" id="arCOG03949">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754780_0_0_2"/>
    <dbReference type="OrthoDB" id="124769at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019206">
        <property type="entry name" value="DUF2085_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09858">
        <property type="entry name" value="DUF2085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15882" checksum="B0B135939314A612" modified="2013-07-24" version="1">MVDWAELRAGLAETRMYLLSHHEPSDYDRTYAVTVLGRRERLCARCTGIYPGIAAGLLARGLGVGPLTEVWLLLVLPLPALLDWTVTRVGDRSGSNSVRTATGALLGYAYGVGLVALFLDGDLRVSAIGAGYGLLAGALLWRRERSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L9</accession>
    <name>R4W9L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_14195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447672.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14195"/>
    <dbReference type="EnsemblBacteria" id="AGN02778">
        <property type="protein sequence ID" value="AGN02778"/>
        <property type="gene ID" value="L593_14195"/>
    </dbReference>
    <dbReference type="GeneID" id="16181131"/>
    <dbReference type="KEGG" id="sali:L593_14195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2904"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="9"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="40650" checksum="1A9C176F2FBEC2B8" modified="2013-07-24" version="1">MRPSSLDTDQRPFVLIWELTQACELACDHCRAEAQAERHPDELTTAEGKELLEQARGFGDGQLVVLSGGDPAARPDLIELVEYGTDLGLSMTVTPSGTASLTRDVIDDLADAGIRRLALSIDGGFALDHDAFRGEEGSFVATLEAASYASEAGIPLQVNTTVCARTVDQLPAIRDLVADLGAALWSVFFLVPVGRGELLDPVSPERAEEVMEWLHEVSREESFGVKTTEAPHYRRVAMQTRRAQDETGGGPSRDGTDGMERSDSGSPGRRSGIVAGDGFAFVSHTGEVYPSGFLPESAGVVPEESIVDVYRDADLFERLRDRSELRGKCGVCEFKHVCGGSRSRAFATTGDPFAADPLCPYVPEGYDGPMPGSGATPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R5</accession>
    <name>R4W9R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446598.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08795"/>
    <dbReference type="EnsemblBacteria" id="AGN01704">
        <property type="protein sequence ID" value="AGN01704"/>
        <property type="gene ID" value="L593_08795"/>
    </dbReference>
    <dbReference type="GeneID" id="16182078"/>
    <dbReference type="KEGG" id="sali:L593_08795"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1802"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_0_0_2"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="36190" checksum="2BF3517D23574429" modified="2013-07-24" version="1">METRKVQLTGGSTFTVSLPKEWATENGVEAGSEVEFHHESNALVLTPRRESGRTEGTLEIGDLEGDRLTRAVMTMYVSGFDIVTLEGDAISADQRQAIRDAAQGLVGVEVIEETSDRVVVQDLLDSSELSVDNAVTRMRLIALGMLEDAITGLLENDDDLAASVVDRDDDVDRLWFVVSRVFRATLRSPSATEELGLPREVCFDYHSSARQLERIADHAAKIAKLAEQLGDIDDEVAAALTELHDDAADVIDTAMDALLEEDSERSTTLARDATDSILDIDQHARHIDELLRERDAHEAQLLGLVVDSLSRSADYGGNVAETALQNAAPKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X5</accession>
    <name>R4W9X5_9EURY</name>
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        <recommendedName>
            <fullName evidence="1">UPF0212 protein L593_10095</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0212 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446858.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10095"/>
    <dbReference type="EnsemblBacteria" id="AGN01964">
        <property type="protein sequence ID" value="AGN01964"/>
        <property type="gene ID" value="L593_10095"/>
    </dbReference>
    <dbReference type="GeneID" id="16182574"/>
    <dbReference type="KEGG" id="sali:L593_10095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2081"/>
    <dbReference type="eggNOG" id="arCOG02119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138334_0_0_2"/>
    <dbReference type="OrthoDB" id="103672at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01223">
        <property type="entry name" value="UPF0212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007564">
        <property type="entry name" value="UPF0212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42199">
        <property type="entry name" value="PTHR42199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04475">
        <property type="entry name" value="DUF555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="167" mass="18499" checksum="5F8436E54C9F1BD4" modified="2013-07-24" version="1">MDCRVVVEAAVPVYDVETPDEAVRIAISKTGEMLNPDLNYVEIEMGERSCPHCGEHLETAFIAADEGLVALELEMTVFNVEREEHASRIARKEIGQCLENIPLEVLEVEIIEDDADGRDDEESSSDESSDADAEDADDPSRTDDEPADEREASGDDEVLPEFEDLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y0</accession>
    <name>R4W9Y0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446883.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10220"/>
    <dbReference type="EnsemblBacteria" id="AGN01989">
        <property type="protein sequence ID" value="AGN01989"/>
        <property type="gene ID" value="L593_10220"/>
    </dbReference>
    <dbReference type="GeneID" id="16182620"/>
    <dbReference type="KEGG" id="sali:L593_10220"/>
    <dbReference type="eggNOG" id="arCOG10182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911693_0_0_2"/>
    <dbReference type="OrthoDB" id="129424at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="6091" checksum="DD5450B07BB1F460" modified="2013-07-24" version="1">MAATNVPSNWSDPSTCPFCGAGLADPGAGFVDHLAESPACESGHADWKENVAGDLAGGWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Z0</accession>
    <name>R4W9Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10470"/>
    <dbReference type="EnsemblBacteria" id="AGN02039">
        <property type="protein sequence ID" value="AGN02039"/>
        <property type="gene ID" value="L593_10470"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2158"/>
    <dbReference type="eggNOG" id="arCOG02945">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010776_0_0_2"/>
    <dbReference type="OrthoDB" id="64323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112027" checksum="0ADAB99D3A822F82" modified="2013-07-24" version="1">MVAVRLAEDERGRVPFALIGVLLLLGSVAVATVQLDDSRIDQNVALAGDRAEAAAETTLRDAVRDAGARAAANPVITPAETTYGEVLDQDRPYRSYLELLIAIELRERLDGTTQRVGNATATVALQPIEDPASARAAIEATTVSATDRGLVAVTVEDVPIAIQRDESTVARRHRTLSVNVTTPVLTLHERTTTFDDRLSGETLEVGSLSRGLTGGLYGLGWTRGYGQYLGLPIEDVIANGHVELVTNLAMLDVQRSVFGNSDREGERRLAEAAVAAAEEQAVGAIAGGFRDAALPYNESTQFAEPSVDPPEDRSTTVGVNDTADRALADLLDGESNGDATPVGDDAGSEPWEYALREYAETAASIDARLRTERVRHERTLVDRERPTGSGWTRVGVVDTEPVIEAVREGDARLPESEAGWYREREHTRVVELTEIETVRYRHENGTIRNGADRYSREVDVGLAIGSRPLPRSWIPERSIGTTDGDRYQALVDRAETRLLAERGGVDEIARTVAATGELTGDATVSPDDEATETISRAAYAALIPDREAIRDVQTRAPVTHALTGASPIADLRERIRADAERYRSIPAEYGSLEERAVVSAEGLYLDHVLRRLGERSSGASGVRESVTEKIGASHDAGLDALLDVGMNYARPEPATIDAQRPAPDLDLTVDAGPGYLSREAETETTVPPPRDPYHPIGVRTSTIASLPTDHVTQKIANFVTGLFGEEREERAPLPMAARTLRSVDAIDEERAADGGLAQPRSELRDAVGSGLEDVNDAAVDALEAETSLDEEAATSVVTEALDRWSDDATRVIAYDDGRATAAVAEVAGSRDGVSRTDADRAQTMMRDAVAENFSDDSTHVALDTVESTSEPARRIVESAVQEGVEQANEQIVNATQDRIRRATGLSVLPTRGVPVTPVPGWWYATANVWHVEVHGTYASFAVRAEQGGPSGGSQLSYVRDGGGVHVDVDGDGRPERLGASSRIQFYASTTVAVVVPTGGGGVGNEGTGFVDVSPGWNATRRGPDCPQTPGGVGQSSPNSCSNPWHEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA15</accession>
    <name>R4WA15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447058.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11095"/>
    <dbReference type="EnsemblBacteria" id="AGN02164">
        <property type="protein sequence ID" value="AGN02164"/>
        <property type="gene ID" value="L593_11095"/>
    </dbReference>
    <dbReference type="GeneID" id="16180044"/>
    <dbReference type="KEGG" id="sali:L593_11095"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091394_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="12306" checksum="5B0E35643F96DB20" modified="2013-07-24" version="1">MSETEPADTNVTERQVPHGSVVVFVGIALLAPPIAGIMVAVHPFIWFAVGLGLIVGGASMDSTRTVTVSEESPRINCENCGARVPGDEPVCEYCDEPLPTSTGYQQTLDEWATETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA22</accession>
    <name>R4WA22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447093.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02199">
        <property type="protein sequence ID" value="AGN02199"/>
        <property type="gene ID" value="L593_11270"/>
    </dbReference>
    <dbReference type="GeneID" id="16182340"/>
    <dbReference type="KEGG" id="sali:L593_11270"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="179" mass="19972" checksum="70059E0D6AED6587" modified="2013-07-24" version="1">MSESDQELSSLDTIFDLLSNPRRRFVLHYLKRVQEPVQLTELAAQIAAKENDVPVDELTSQQRKRAYVSLYQTHVPKLEEVGVVTYDPDTGNVALTERADDIDEQLDRNGDDVPWQWLYLGVALTGLVGVLLTPLAGGGSADQFRIGLFVLGAIAVIAIANYVYVRRSKRDTLALIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA76</accession>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN02469">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="167"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02469.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="39953" checksum="8DBE713C2F9DAA9E" modified="2013-07-24" version="1">MTEYTVAVIGTGPDPAAPSTEGFAMGYRHAEAVVANEQCELVACADVVPENAAAFAREFDLPESAAFEDYETMLAEAEPDLVTVAVPPSIHEEIVVGCAESGIPRGVHCEKPIADTIGAARRMVETCQESDVQLTFNRQRRFGKPFTEAKRLLDDGAIGDLQRVEITWGDFMDTGAHTIDLAGMYADEATPEWVIANLDYREEDKRFGVHQENQMWAQWRYDSGVYGVMSTGAGDDFLDTAMALRGEEGSIHIDVEGGPMLELRQGEEREAIDVDGENMHATGSEGDDRYGSYFHDRAIDDVVAGLDGEKASELRGELGLQTAEVIFGGYESVRKRGRVELPADVEDNAFLDLVDSGELSPEPSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">L593_13325</name>
    </gene>
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13325"/>
    <dbReference type="EnsemblBacteria" id="AGN02604">
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        <property type="gene ID" value="L593_13325"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="71" mass="7387" checksum="47F405F909B5A6DF" modified="2013-07-24" version="1">MGERCAAGEPADGCREVTTNTNPVDVPNEFARPVSVPERAAEAAAGEDGDGQERCVGGANEQSSTQVPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA6</accession>
    <name>R4WAA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447513.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02619">
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        <property type="gene ID" value="L593_13400"/>
    </dbReference>
    <dbReference type="GeneID" id="16180588"/>
    <dbReference type="KEGG" id="sali:L593_13400"/>
    <dbReference type="eggNOG" id="arCOG14227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="126166at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="15790" checksum="07C5322471E172B0" modified="2013-07-24" version="1">MDADERTIYFARTAALAAASTIVITASFIGVLALLEGEFSTLDSRIPWYLVATSLIFLATIFLLEEHGADGVEIIAITAVVTILGFILIVLAVEGVNYARTNPGDVFVDKLVLYFLAAGMFGTGIGYWGIKHWREFTGQRQGAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE7</accession>
    <name>R4WAE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447718.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14425"/>
    <dbReference type="EnsemblBacteria" id="AGN02824">
        <property type="protein sequence ID" value="AGN02824"/>
        <property type="gene ID" value="L593_14425"/>
    </dbReference>
    <dbReference type="GeneID" id="16180988"/>
    <dbReference type="KEGG" id="sali:L593_14425"/>
    <dbReference type="eggNOG" id="arCOG01250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045500_0_0_2"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="344" mass="39857" checksum="C1A665D8729458A2" modified="2013-07-24" version="1">MRGKRDLGPREARERFLDRRRAENTERTVRTYDNRLTAFVEFCEENGIESMSRLSGWDLDEYRADREADEISPTTLRGSLVAVKQLLDYCEDLGIVEDGLAEKVNPPTLDRSEESSDQQLAHEDAEELIEFYRRDRTWKGRPEHAVLEVAWHVGCRMSGLRALDLRDYDPDAQTLEFRHRPPHTRLKNKEAGERVVGISEQVVAALETYIARERVDKRDDQGREPLFCARQGRPSDSTFRAWSYMGTQPCLVEQCPHGNRRETCDYTRRNFSSKCPSSRALHAVRTGSITWQLLQGLDIETVAKRVNAQPATIRRHYYKAGLHEEFEELRADTTLKLDIEDTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE9</accession>
    <name>R4WAE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447728.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14475"/>
    <dbReference type="EnsemblBacteria" id="AGN02834">
        <property type="protein sequence ID" value="AGN02834"/>
        <property type="gene ID" value="L593_14475"/>
    </dbReference>
    <dbReference type="GeneID" id="16181284"/>
    <dbReference type="KEGG" id="sali:L593_14475"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_0_1_2"/>
    <dbReference type="OrthoDB" id="65191at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="272" mass="29241" checksum="B540E9AD7362F4D7" modified="2013-07-24" version="1">MTWIAIARKDVFDAARSKSIWILAGVFLVTFVGVAFAIPRLGEPEFEVFLELSASVVVVLVPFAGIATGYKAIVGERESGTVALLLSLPHARHDVTIGKVVGRSLVVAGPIVLGLVAAAVVVLVRYPTFEPLRYALFVLATLAYGVTFLSIATGLSMTTRSSRRVTGGAFGAYVLLVMFWNQVVDLLVVVLWRFRPRALADPPTWAEFATFANPRVTYTYLVGDVLGAGGGPPATEIGTEWFVSPAGGVMVLLAWIVVPLLLGHRRFVRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS21</accession>
    <name>R4VS21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00275"/>
    <dbReference type="EnsemblBacteria" id="AGN00010">
        <property type="protein sequence ID" value="AGN00010"/>
        <property type="gene ID" value="L593_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.55"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_0_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="168"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="338" mass="34470" checksum="DAB20458D1FB6152" modified="2013-07-24" version="1">MSDSVGSIGDRLAGSSTSVPHLALAVAVVGVAWSAILIRWSDAPSDVIAFYRVLFTLLAVAPVALLRHRQAFGRIARRDVVVASVAGVALALHFLAWIESLAWTTVAASVTLVQTQPVFVALGAALVLDERVDRRTVAGIVVALFGASALTLVQSDASLPAGGSAFVGSTLAVIGAVAAAGYVLAGRSLRQRIPILPYVTVVYAACVATLFVAVSIDGATVVSVLRGDASAAGPAGILDAGAFVGYPAREWLLFLAMALGPGLLGHTVVNWTLEHLRSTVVSVALLGEPVGSTVLGVVLLDEVVGPGVVVSMAVVLAGIYVTATARANRDGEPEGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS78</accession>
    <name>R4VS78_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444969.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00600"/>
    <dbReference type="EnsemblBacteria" id="AGN00075">
        <property type="protein sequence ID" value="AGN00075"/>
        <property type="gene ID" value="L593_00600"/>
    </dbReference>
    <dbReference type="GeneID" id="16180092"/>
    <dbReference type="KEGG" id="sali:L593_00600"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.122"/>
    <dbReference type="eggNOG" id="arCOG03287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_3_1_2"/>
    <dbReference type="OrthoDB" id="10538at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="511" mass="58384" checksum="ABDFDD0017295791" modified="2013-07-24" version="1">MTFRGFDYSNYPQVSGELFRAVQQRGPFDDAKRFVDSVPRVQADLLHERYLALEEAGTLDVDAFVEEHFRVPEPIAANPQLQPDRTMEEHVEALWEPLTRTFNVDPDSGSTLVPLPEPHVVPGGRFREMYYWDSYFAMEGLAASDRLELVEGMIENVASLLDRFDFVPLGNRVYYDSRSQVPLFYRMLRILERERGPAAVEPYLDALQTEHAYWMDGSDLVGSVGDRRSHRRTVALPDGTVVNRYWDDRASPRPEAHWNDRELAKKVPTDDRPRLFRDLRAAAESGWDFSTRWMETGEDLTSIRTTELVPVDLNAVLFGMETALAEWLPRVDEHEAADRYASAANRRREAIERYCWSDDASLYVDYVWTEEQRSEQSTLAGAVPLFTGIPEQDRADAVAERLRELFLERGGLLTTLEESGEQWDAPNGWAPLQWMAIEGLRRYGHDDLAAEIADRWLAVNRTGFETTGQMAEKYDVESKSVSPDSGEYDLQYGFAWTNGVVAALTAREETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSF7</accession>
    <name>R4VSF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11413" checksum="C4DE3BF50A4A87A2" modified="2013-07-24" version="1">MTDDNAGFPWPPAMFAEQFQEASEDAMQRQQELYKQWLSMSADGTSGGLSELSALSTGTATFKSRVQSGGRISIPDAEREALDIEEGDIVQTIVVPVKRDRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSI7</accession>
    <name>R4VSI7_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
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        </source>
    </evidence>
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    </evidence>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AGN00460.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7529" checksum="168F0A737ADE6AC6" modified="2013-07-24" version="1">MATTDNAFDGLTEYCEACETDTLHQVSVQILAESRKPENVEFSREPYRVAECQRCGERVSQRMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTJ2</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
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    </evidence>
    <sequence length="48" mass="5032" checksum="FE17FC3EA68111F4" modified="2013-07-24" version="1">MIDVSGLPGWTQAAALIGVVLVEAMVLYVGYGALEQAIGQKLIDRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUG3</accession>
    <name>R4VUG3_9EURY</name>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
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    <dbReference type="eggNOG" id="arCOG01069">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
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        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="331"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="451" mass="47264" checksum="223B997CEEDAD0DF" modified="2013-07-24" version="1">MTDTFVVIGGDAAGMSAASKARRENPDLEIVAFEKGDWVSYAACGMPYYVKGDVESLDDLVQVTPDAFRTERDIDLRTNHEVVDVDPDAQTVTVSTGNDRFEQPYDQLLIATGARAIEPPFTGMDLEGVFTIHDLDHADAIQTYVSETDPETAAIVGGGYVGIEMAEALASRGLDVHLFEMLPHVLQPFGESVATVVEDHLREQGVELHLDTPVAGFGGEEAVSSVELDSATIPADVVVVGVGVEPNVELAADAGIEIGETGAIAIDEYGRTNYESVFAAGDCAEATNVVTGDADHVPLALTANRAGRAIGQTVTGTPTDVGEIAGTAIVKAFDVGAARTGIIDEERARDAGFDPVSVEITAPSRAHYYPGTQELTVTLVADRESERVLGASVVGGEGAKRIDTVATALHAGLTVTEVETLDLAYAPPFSPVWDPIATAAKVLAGSLKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUN9</accession>
    <name>R4VUN9_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00940">
        <property type="protein sequence ID" value="AGN00940"/>
        <property type="gene ID" value="L593_04955"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04955"/>
    <dbReference type="HOGENOM" id="CLU_2519910_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="84" mass="10088" checksum="0DD563EC80C347E2" modified="2013-07-24" version="1">MWLHEMNDKSLLRILFGSFESCLNDILREDGPLFVVKRHLPEWYDIVERVTSHFRSMRIRRNHNRITKFVIREIPACPLARVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUU6</accession>
    <name>R4VUU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01005">
        <property type="protein sequence ID" value="AGN01005"/>
        <property type="gene ID" value="L593_05280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05280"/>
    <dbReference type="eggNOG" id="arCOG11189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12699" checksum="F322189B576B6892" modified="2013-07-24" version="1">MPEFVGLTAINHHDAPHTAHVRLELDDETVYRKSKQIAAGGSRDSRAAVFSDYPTAAEPYVLSAWRDDHPEAEAMTLDFASFDTECLGASVQIGTFGSDVENPELAIYYTTNCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV47</accession>
    <name>R4VV47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446004.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05805"/>
    <dbReference type="EnsemblBacteria" id="AGN01110">
        <property type="protein sequence ID" value="AGN01110"/>
        <property type="gene ID" value="L593_05805"/>
    </dbReference>
    <dbReference type="GeneID" id="16181859"/>
    <dbReference type="KEGG" id="sali:L593_05805"/>
    <dbReference type="eggNOG" id="arCOG07780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825431_0_0_2"/>
    <dbReference type="OrthoDB" id="102755at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="34557" checksum="1EB2A4DD17D80C2E" modified="2013-07-24" version="1">MPSLTSCYFCGEAVGASLAEYAIPDDAPTDEQVSLTLCAQCQGKLSALLEELPQHGDLPADAPEESAGDATDTDDTPGTNPVDDPGANDEAGRDRAAEALTPASEDLTATDTQSADQTAGDDGTADESDPDPVTGDREPIFADDEGALLDDDLPVDADDEQAADQPFTDASAEEDGTDDSAPEPVVSASARESAPPADAGKPEADGADTGKTGGAGPRDSTNADESPSDSSPGDEPPTTDERTGTTIATGQTETATESASTNESAAEDPLADVSPRTYNRVVRLLQNREFPVDRADFEALATSAYELDHGECSAALDGAIEKGLLVERDGSLHRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV84</accession>
    <name>R4VV84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05980"/>
    <dbReference type="EnsemblBacteria" id="AGN01145">
        <property type="protein sequence ID" value="AGN01145"/>
        <property type="gene ID" value="L593_05980"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05980"/>
    <dbReference type="eggNOG" id="arCOG13426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465171_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="184" mass="20300" checksum="145ECC4A47D4C4D2" modified="2013-07-24" version="1">MVALMPETTTKTVKVPDSRAEKWDEYVQENPEVDSISHLIRLAVQREIDNDRPSAQPVADPTEDTSSGEILTAVQGIQTAVSDLEERMSALEEVEKAEASYDLQKAIYAVLPEDPDCVIDDEIPGPENVEEADPITAREIAQLLGADYPEVEGTIDGMVEATAEVQRSDVNHDGRYYWKRGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVT2</accession>
    <name>R4VVT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445260.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02075"/>
    <dbReference type="EnsemblBacteria" id="AGN00366">
        <property type="protein sequence ID" value="AGN00366"/>
        <property type="gene ID" value="L593_02075"/>
    </dbReference>
    <dbReference type="GeneID" id="16180064"/>
    <dbReference type="KEGG" id="sali:L593_02075"/>
    <dbReference type="eggNOG" id="arCOG06208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109297_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="161" mass="16137" checksum="C2BF5EB03D4C3FEC" modified="2013-07-24" version="1">MTTTLWLALAVLLLLVGVVGSVTPMLPGPLLSVGGVLLYWWSTGYGEPGLVFVVASVVLGVGTVLLDWLASAVASKAGGASTASAVVAAIVGTLAFFVAGPVGTVLGIAVAVFATEIYLHGDLRQGSKASLYATIGVLGSAVVQLFVTVAILLGFLLVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVW3</accession>
    <name>R4VVW3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pilin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445295.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02250"/>
    <dbReference type="EnsemblBacteria" id="AGN00401">
        <property type="protein sequence ID" value="AGN00401"/>
        <property type="gene ID" value="L593_02250"/>
    </dbReference>
    <dbReference type="GeneID" id="16180429"/>
    <dbReference type="KEGG" id="sali:L593_02250"/>
    <dbReference type="HOGENOM" id="CLU_1811530_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="14362" checksum="6EB01EC62AD012FC" modified="2013-07-24" version="1">MADSEGLSREQFRLLLLVAIGIGAVLLLAIIGVTAASVVWGTGGGGGAPTAAFEVQTIDRSDGVAANVSHAGGDAVNPESIVVEVNGEPRGTWTELGGQGPDIVARGHQLVLDDVAPGDSIAVVWTGDDERVELGRGTIRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW62</accession>
    <name>R4VW62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07575"/>
    <dbReference type="EnsemblBacteria" id="AGN01460">
        <property type="protein sequence ID" value="AGN01460"/>
        <property type="gene ID" value="L593_07575"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07575"/>
    <dbReference type="eggNOG" id="arCOG02825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036724_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="114"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="268" mass="29733" checksum="985B4D79AA1067EC" modified="2013-07-24" version="1">MALLTPGPTLPAWAATAVQTMIDETDAEIALVVQDGSSDDRGAVETVRRLVELREWGLVAGSRELFGDDLDHQSRTPVTAIDGLVEAERFVCEPRQVDGWKHALPSRAVDRLGATDVAVRMGFGFLVGDALTAPTHGVLSYHHGDFREYRGQPAGFWEYVHGRDIAGVTLQRINETLDGGEVVAERDVVIADAPTWDEVRRRLFDASTDLLAEGVTRLERESFEPERLSQEELGDLYSLPRGRPVLTYLEKSVRGKLRRWESLGEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWA9</accession>
    <name>R4VWA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03050"/>
    <dbReference type="EnsemblBacteria" id="AGN00561">
        <property type="protein sequence ID" value="AGN00561"/>
        <property type="gene ID" value="L593_03050"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.617"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="36"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="41341" checksum="36CE8A3B9B5B8C30" modified="2013-07-24" version="1">MTPSDTRHADDAMTPLELRADVPALQEGAYFNFGAHGPSPRFVVEAAEAFLESHEYESPILDDPYETAFDTFEMVREAVADFVGAEAEEIALTESTTAGINAIAGAIDWEPWDVVVRTDLEHPAGILAWQRLEREGVEVRVVETTDGRVDPEEFAEAVDGADLACFSALTWTHGTRLPVADLVDIANDAGAFTLVDAVQIPGQAELDVSEWGADAVAAAGHKWLLGLWGGGFLHVDREAAEELEPRTVGYRSVEKPTADVFEFEPGAKRFEVGSANPASHVALAEAIEAIDEVGVDRMEERTLDLAGRLAGGVPEERLLSPAEPESGLVTIDVPDPEATVERLREDGIVVRPLPFPDAIRASVHAVNTAEEVDRLLAGLEDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWG1</accession>
    <name>R4VWG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine/O-acetylserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445515.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03350"/>
    <dbReference type="EnsemblBacteria" id="AGN00621">
        <property type="protein sequence ID" value="AGN00621"/>
        <property type="gene ID" value="L593_03350"/>
    </dbReference>
    <dbReference type="GeneID" id="16182441"/>
    <dbReference type="KEGG" id="sali:L593_03350"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.679"/>
    <dbReference type="eggNOG" id="arCOG00061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_2"/>
    <dbReference type="OrthoDB" id="40508at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="48598" checksum="56472F454249DB59" modified="2013-07-24" version="1">MSDEDTPDPESHRRHRLGTRAVHAGQEEPDPATGARAPPIYQTSSYVFPDADDAAGRYALERGGHLYSRISNPTVEVLEERLASLENGAGAVATDSGMAALDSITLVLARAGDNVVCSTDTYGGTTTYLSKTAERRGIEARFVPTLDYEAYEEQIDEDTAYVHLETIGNPSLVTPDFERVAEIAHARNVPVVVDNTFATPALCRPLEHGADVVWNSTTKWLHGAGTTIGGAVIDGGDFDWAAGGYEELAGENPAYDGVDFSERFSDAPLAAAVRLRAVRSLGNQQTPFDAWQTLQGMETLSLRMRQHSENAAIVAEYLQEHEDVAWVAYPGLESHETHENARRYLGDPPEEASRGAGTAVDGYGGMIAFGLEEGFQAGKRFCERVELASFLANVGDAKTLVIHPASTTHAQLTEEEQLEAGVSPDLLRLSVGIEDPADILADVDAGIEAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWH5</accession>
    <name>R4VWH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AGN00636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445530.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03425"/>
    <dbReference type="EnsemblBacteria" id="AGN00636">
        <property type="protein sequence ID" value="AGN00636"/>
        <property type="gene ID" value="L593_03425"/>
    </dbReference>
    <dbReference type="GeneID" id="16180091"/>
    <dbReference type="KEGG" id="sali:L593_03425"/>
    <dbReference type="eggNOG" id="arCOG08194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063976_0_0_2"/>
    <dbReference type="OrthoDB" id="118821at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="25838" checksum="42EF01EEDC70D173" modified="2013-07-24" version="1">MLSPTVVAVLVVVALLAGALTGIAGFGFALLGTAVAATLIDPAQAVVLLVLPILGVNLSLITELGPEDARECVARFWPFLGAALLGTTLGMVALDLIPRSPLLLGLGVLTLGFVANRLGLLPGVETAADRCFAETTPAMVGLGAGSGLLFGATNVGVQFVAYVRSCDLRQQVFVGVLAMLFLGINGLRVASAAALGLYPSVGFVAVSAGLAIPAVAGSLVGSRIRPRISQRLIQRIVLGLLLVVGVRLVASGAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWL6</accession>
    <name>R4VWL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03600"/>
    <dbReference type="EnsemblBacteria" id="AGN00671">
        <property type="protein sequence ID" value="AGN00671"/>
        <property type="gene ID" value="L593_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03600"/>
    <dbReference type="eggNOG" id="arCOG10155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200163_0_0_2"/>
    <dbReference type="OrthoDB" id="127660at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="67" mass="7201" checksum="39D90BFCB38B1712" modified="2013-07-24" version="1">MHGQPISTRMDLRYVAGVLLLAMVPMALYATGQTMVAAVSLVNIVIIYASLYVMFGPAESPHGHSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX72</accession>
    <name>R4VX72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_04550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445755.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04550"/>
    <dbReference type="EnsemblBacteria" id="AGN00861">
        <property type="protein sequence ID" value="AGN00861"/>
        <property type="gene ID" value="L593_04550"/>
    </dbReference>
    <dbReference type="GeneID" id="16180992"/>
    <dbReference type="KEGG" id="sali:L593_04550"/>
    <dbReference type="eggNOG" id="arCOG03633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053152_7_0_2"/>
    <dbReference type="OrthoDB" id="105475at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="16245" checksum="D05C587CB64D1984" modified="2013-07-24" version="1">MTEDDGLQRCGLGIRGIAMTVDSFVWLALFMIATLAIGAATGQVETTANEVDATVEGTAGTVAFLTWLGLGVGYHTVLEWKYGKTLGKYLVGIEAVEADGSVLSLRSSLVRNLLRLIDWLPMFYGIAIVLVAISSDHERLGDRLGGTAVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXC8</accession>
    <name>R4VXC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09750"/>
    <dbReference type="EnsemblBacteria" id="AGN01895">
        <property type="protein sequence ID" value="AGN01895"/>
        <property type="gene ID" value="L593_09750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09750"/>
    <dbReference type="eggNOG" id="arCOG06787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2802440_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="67" mass="7824" checksum="D987FB5C0AFB0A73" modified="2013-07-24" version="1">MVHSPRIEHSDGQPGNFKLYRAYHEKLRRHDGWYCFVVYRPTRSGLTVITDRVQQAADLPHSNAMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXU1</accession>
    <name>R4VXU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445975.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05660"/>
    <dbReference type="EnsemblBacteria" id="AGN01081">
        <property type="protein sequence ID" value="AGN01081"/>
        <property type="gene ID" value="L593_05660"/>
    </dbReference>
    <dbReference type="GeneID" id="16181877"/>
    <dbReference type="KEGG" id="sali:L593_05660"/>
    <dbReference type="eggNOG" id="arCOG01927">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830640_0_0_2"/>
    <dbReference type="OrthoDB" id="102783at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="15349" checksum="D29227670FBA8CB4" modified="2013-07-24" version="1">MVVEVERVVEVDAGIDAVWDVLADPARRGRAISVVDSFRVEGQEFVWQVSLPIPVINRTIAVRTRDEVREEPTFVRFTGDSKAFGVEGEHELTELDDGGTRVRSSFAVDGKLPGVERYFERNIDEELSNLLDSIETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY43</accession>
    <name>R4VY43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_06135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06135"/>
    <dbReference type="EnsemblBacteria" id="AGN01176">
        <property type="protein sequence ID" value="AGN01176"/>
        <property type="gene ID" value="L593_06135"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06135"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256759_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="72"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="351"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1364" mass="154789" checksum="84839880C47F35E0" modified="2013-07-24" version="1">MLFNRQLLGTDHDGAPVTDAVKYTSEAQKRRLATPYDGDDPFVDEIIDIFGFNPLDFQVDSWQLINDFHQQRHDTGEPHAAILSAPTGFGKTEAFLGPLYQQLRNGEQDTTVIVYPRRALLQDQLGRILQHIHSMRPAGEQAPLSVGVYMGGMPYNVEDVRDDYFESENGRETFQLAHCWCGDETTTNAFTYDGSSNSYTIRCEADDTHSFTNNELVLSRQQIKDGETPDILLTTLEALELFALKPNYDIVDDVDTFVLDEVHLYTRLRGAHAAKIIGNINDITEQPLLWIGASATIDNADRFIRKLFDFPSGRLATVDVPESDLKQDHDDQEHYYFLLSPEDGPGASSMMIQQLLLIGHGLLRDTDGNEGKALSFIDSISQVNQKNDQLDDAERGDGQGEPPLWHHHTDRSPRGQQPANPEADWADIADAMGYDFIEDRALDFLPVYSQIGFDAEDAADSDIFLSTSFLEVGIDIGEIKHVTQYRTPQNLSSFVQRTGRAAREEGMDAHIFVFLSNLTNDANMFYRADRFLSSELRTPLKPDNDVIEWIHTTLNTYYTRASDIDDRRIRRGEEATFLEEFLTQDKQYQEFYQLLLNPSDFLLAEFGIDETVEPLTTEAGIETFRDIINRREAELEEEFAEVEDLINIDSGDITRSDNAFEQYVDEVRQRTLEVISHYVEIVDQYQDHVDGGDAPDLVDDLNELYDEFEELREEARDGYRGAETERVEQYEQLFGRIISAVGDLTGLRAQVNIHIDDRPEDVSLDRITDLSDAVEILGSIAGDGRLEENIDERYQINYLRRVLDQLGEYRDLERDPDNRVNRPHMSLHYVKHLLRAAYYLHRYLQVTDRTYSDEIWYVPPSYFDNSGQFFTVVDPDGFDDEETIDSLVHTNAPYRSEFQNESTNLHVFLPETEVESYGEQPTGNEVQFDFSDIPGDQRNGMLVPDSIQLTEIPDVTGQRALNIVAYCPQCLTLLDDQRCVRHNEIAWGKVHAEPQVRTVARDTDVEAATGSLALAGLRGQVTLDGVSLDITPARPMGDMGIQFTGDDRIQREIDSPDTPLGFDLKTRGLIYDLTDFIDYVEDNEDLIADVARYKNLDGVPIDELAYHTAAHFFLHLVADVGGVNPSMLFYGLDPEEGIVFIFERTEGGQGIVDLVYDELENDPGTLLESLVRITYNTQVINEQLWANPDFVEDLPERGVDEDAVQHCVDTHLDEQLDMVFPEIRDEVVQEVLSTCDRAAQLSDEESIPLRDAYTVKHTVADAQLDGADTFPEGRVDALNVDLDELHRIESLFFSPDIDGCVENLHTGECISGHDQEEVLSHVLLQELRHHLVDFVDTDDAVDEMFDREQVPAGEINDTSIYFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYJ8</accession>
    <name>R4VYJ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447229.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11960"/>
    <dbReference type="EnsemblBacteria" id="AGN02335">
        <property type="protein sequence ID" value="AGN02335"/>
        <property type="gene ID" value="L593_11960"/>
    </dbReference>
    <dbReference type="GeneID" id="16180035"/>
    <dbReference type="KEGG" id="sali:L593_11960"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051124_1_0_2"/>
    <dbReference type="OrthoDB" id="94462at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="21155" checksum="5171C6949B2A2384" modified="2013-07-24" version="1">MKLIPNEDDRGQVGIGTLIVFIAMVLVAAIAAGVLINTAGFLQDQAENTGTESTAQVANNLQVQTQTGIVNNAGTGDNISEIHVGVQPAAGAEAINLEELTIQYNNENSTNFIHNDSTNDGVSNTFTTTAVSAEDGSDNVMSQSGDFYEIVLDLSATNSTANLEPSEEAEVTITTPQGSQTVVTLRAPDSLATADPGETVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYM5</accession>
    <name>R4VYM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446230.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06945"/>
    <dbReference type="EnsemblBacteria" id="AGN01336">
        <property type="protein sequence ID" value="AGN01336"/>
        <property type="gene ID" value="L593_06945"/>
    </dbReference>
    <dbReference type="GeneID" id="16181937"/>
    <dbReference type="KEGG" id="sali:L593_06945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1419"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_4_2"/>
    <dbReference type="OrthoDB" id="51024at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23571" checksum="69BC9FB4C23C9CC6" modified="2013-07-24" version="1">MQLIAHRGFADERAENTIPALQRGAAIADAVEFDVRRCASGEPVVIHDETVDRVTDSSGPVAEYDADALAAMDVLGSGDGVPTLAEAVAAIPTETPLLVELKERGLAEPVLDALSDRDGRVLVASFDEAALRELRAADSSAELATIAGDLRDRPIATAVELDCSAVMVRARLAALPTVRRAARDLDLDVFVWTVQRRPVAGGLAWLGVDGVIIDRSDVVPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYP5</accession>
    <name>R4VYP5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase I</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_12210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12210"/>
    <dbReference type="EnsemblBacteria" id="AGN02385">
        <property type="protein sequence ID" value="AGN02385"/>
        <property type="gene ID" value="L593_12210"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12210"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2511"/>
    <dbReference type="eggNOG" id="arCOG04542">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="4">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="160" mass="17758" checksum="AA9161B601ED9C21" modified="2013-07-24" version="1">MTDNQFHYEETTAVPVEDSEIDLEKARRGTRLLLEAIGEEPNEAPLTETFERRGPEILATLTEGTRETAKPDLRTFEADADELVVKTEIPIYSLCEHHLLPFFGVAHIDYRPGEEIVGLSKLPATCAGIHAGKYDFDRRRGARSHSQGSCGDVQAVHGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZB6</accession>
    <name>R4VZB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protein kinase PrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446495.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08280"/>
    <dbReference type="EnsemblBacteria" id="AGN01601">
        <property type="protein sequence ID" value="AGN01601"/>
        <property type="gene ID" value="L593_08280"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08280"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1697"/>
    <dbReference type="eggNOG" id="arCOG02892">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361184_0_0_2"/>
    <dbReference type="OrthoDB" id="3283at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="821" mass="90591" checksum="7F13DE9A62DAF781" modified="2013-07-24" version="1">MSGEEYVDAADRSLAAAYEPPMDLAAYVDLVLEQPDLAGHAAKYLVDAIEAAGTRTVIERGEEFERYRFFDDPYNDGEHAILGNTATLNRLVDDLRSIAAGRGKHEKIVWIEGPTATGKSELKRCLVNGLREYSKTEAGRRYTIEWNVRGASDTRGLSYGGDEPADEDDWHESPVQTHPLSVFPEDVRDDIVAAINDRREGHVPIRVETELDPFSREAYEYLEEHYRRQGVEDLFSAITDPDHLRVKNYVVDVGQGIGILHAEDTGGPKERLVGSWMAGMLQELDSRGRKNPQAFSYDGVLAQGNGLVTIVEDAAQHADLLQKLLSVPDEGRVKLDKGIGMDLDTQLLVISNPDLEATLNQHAERADADPLKALKRRLDRHDFTYLTNVSLEAQLIRRELTGEHEVWTRTDATDRDERVRAPATLSVRTSGAIAPGDLDGAGSSEDHIGEGALAGADSVIAGSAGDGDDAGVRDVASVRDVELAPHAIEAAATFSVLTRLTDEETGSDLDLLEKALLYDRGYLTDGDERVGIDEFDVDGSRDGHHGVPVTFTRDVLAELLQADRDRHHPDLPVEDVVLPEDVLDAMVAGLETAPVFSPGERTEFESRVGPVREHVRERQTDDVIDAITAERSVDPEAVSEYVKHVYGWATGEPIENDRGERIQPDPLTMKVFEIESLGRFVEGDYTGNEASDEVAQFRQEKVVTALNRHAWEHRGEDFAVEAVDLTAIPVIADVLEGADWDDVRRRHEEFDPSQWADPPANTETAAVKERTIEHMVAEQGYSVASAELTSRRVMETVADDWEADQPGDHTGDEFPDRNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZG9</accession>
    <name>R4VZG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447559.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13630"/>
    <dbReference type="EnsemblBacteria" id="AGN02665">
        <property type="protein sequence ID" value="AGN02665"/>
        <property type="gene ID" value="L593_13630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180743"/>
    <dbReference type="KEGG" id="sali:L593_13630"/>
    <dbReference type="eggNOG" id="arCOG09752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1821098_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="14705" checksum="51538EE4A26D1993" modified="2013-07-24" version="1">MSTSTASGYQVDETPTKTKLLTALFAIGGVLSLPTGILLLGASSAPAVGVAGNVTGILTVLAIGTFVFGGISLTLAYGLWNVRAWSWYGTVLVTVSSIGLSLWVLLQAGSLPWYNLLIALAVLWALWDDQAAFGLDHQLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0B3</accession>
    <name>R4W0B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_15105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447849.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15105"/>
    <dbReference type="EnsemblBacteria" id="AGN02955">
        <property type="protein sequence ID" value="AGN02955"/>
        <property type="gene ID" value="L593_15105"/>
    </dbReference>
    <dbReference type="GeneID" id="16181718"/>
    <dbReference type="KEGG" id="sali:L593_15105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3085"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41440" checksum="762A43A84A69C791" modified="2013-07-24" version="1">MDFRLNQEQRQIRDAVAEFVDEEVVPRASEIDSEDEFPADLVDQIGDLGIMGAPFPEEYGGAGLDYHSYAIALEEISRGSGGLGTVVAAHVSLAGNMLYEFGDEEQKQEYLVPLAEGGDVGAFALSEPGAGSDVPAMETTATYDEAAGEYVVDGGKLWISNGSVADTVTVFAKTDADAGRNGISSFVVRPDEDDGFHVEGTEDKLGDKGCPTAELRFDDLRIPEDRRLGEEGDGFVQALKTLNGGRITIAARGVGIARAALDAASEYATEREQFDQPIGEFQSIKHKLADMDTKVQAAKLLMHKAADRKIRGESYVKEAAQAKLYASEISREVANEGIQIHGGYGYVKDFPAERFYRDAKLNEIYEGTSEILRNTIGDRVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0C8</accession>
    <name>R4W0C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446840.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10005"/>
    <dbReference type="EnsemblBacteria" id="AGN01946">
        <property type="protein sequence ID" value="AGN01946"/>
        <property type="gene ID" value="L593_10005"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10005"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2061"/>
    <dbReference type="eggNOG" id="arCOG02276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249283_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="473"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="667"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="788"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140056" checksum="1DB59A2335BD3259" modified="2013-07-24" version="1">MASPSLTEALRETLSRFESLGEPRTTTEVADALDLGRRSTYERLERLVDRDRLETKKVGGNGRVWWRPPATADVPPDWSATAASLIDDVLDGAEVGIFVLDEDFEVAWINDATERYFGLDRDRVLGRDKRRLVEEQIAPVVDDSETFTDTVLATYDDNTSTEQFECRVTADDEARWLEHRSKPVETGAYAGGRVELYYDVTTRTEVERARERDRAQFESVVDAVEEYAIVMLDPDGHVQTWNEGAEQIMGYAAEDVVGEHFSTFYTDDAREAGVPEANLAAASSDGPVDDEGWRLRADGSRYWATVTITAHRDDDGAIDGYVKVTRDMTERLEHERKLQHERDLLDQVQEASPIGIGIFDTDGELYRGNRRFTELLGWNDADPSGYSLGEQPLLDADGDVIPYPERPAARALSTGDTVTDQRIRVDGPDGRTRWLSVNAKPVGGEVDGVVVTMTDVTRLEGQARRLERQRDDLQHELEDVFERIDDGFFALDADLQFEYVNERAGSLLDRSPSELVGTHVWDAVEAGSKAEAAFEEALETQESVSFEEYYEPQETWFENHVYPSESGLSVYFEDITERKERERQLERQRELLRHTERLAGTGGWETDVQTGNQRWTQGLFDMHDVDVDDPSQELVPTAEEYISMVAPEHRDAFRDAAERCMTEGESYDEEIPITTAEDRERWIRTIGVPIHEDGDVVALRGAAQDITERKQRERELEEYRRWSETLVENFPAGAVALVDRNLRYVTFAGTPEGDTDVTRTDLQGRRVRDALPEQIADTVVPAYQAALDGDPSEFVDTIDDRVYQFHFVPVRDDDGEVFAATAMSQDITQRVEHQRQLEQQRESLAALNNLNSVVRDITEAVIEQSTREEIERTVCERLADSESYLFAWTGEVDPASQTVDLRAEAGVEGYLDGVTISVDPDDERSEGPTGRAFRTGEPQVTQDIRADDRHDPWRDHVEQYEIRSSAAIPIAHEGTVYGVINVYADRPQAFEGQELAVISRLGEVVGHAIASVERKQALMSDELVELEFRIQDVFAGLDAPETDGTITFDQVVPVDDGEFLVYGTMAPDAVDTMTTLTEDLPHWEQYTIRSDGDPMGFELRMTDPPVVGVVASHGGYVAQAAIEDSDYRMAIHLAPSVDTRRIVDAVETAYSDAEMLRRRQISRVHEDRKDFQRNVVNDLTDRQRTALQTAYHAGFFEWPRDTTGEEVAEAIGVASPTFHQHLRKAERKVLDAMFSSPLHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0D4</accession>
    <name>R4W0D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446850.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01956">
        <property type="protein sequence ID" value="AGN01956"/>
        <property type="gene ID" value="L593_10055"/>
    </dbReference>
    <dbReference type="GeneID" id="16182584"/>
    <dbReference type="KEGG" id="sali:L593_10055"/>
    <dbReference type="eggNOG" id="arCOG06370">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197240_0_0_2"/>
    <dbReference type="OrthoDB" id="126696at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="8013" checksum="6017AB6BC5D7BC9C" modified="2013-07-24" version="1">MHTRSSAEYARLAKGGFGIGFAMLLVGVLGEVLVPIVFGSIPGWEATLFFDLEVIGVLTALISPFLFGIFLPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0M7</accession>
    <name>R4W0M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446990.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10755"/>
    <dbReference type="EnsemblBacteria" id="AGN02096">
        <property type="protein sequence ID" value="AGN02096"/>
        <property type="gene ID" value="L593_10755"/>
    </dbReference>
    <dbReference type="GeneID" id="16180753"/>
    <dbReference type="KEGG" id="sali:L593_10755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2217"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_2"/>
    <dbReference type="OrthoDB" id="14436at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="163"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="411" mass="45177" checksum="571D8C6A9323CF7A" modified="2013-07-24" version="1">MPTQLPASEFATRLDAVRDRIADAEVDAGVWVSATSIEYLTGFAHIQTERPVVLAVTQDRIELTVPRLEVERVESNPRIDHVHHYRDYPGGNPIGVVVEMLDGLDVESIAADGEGAPGVMGYAGPSFADAWERADATDGKLTVETQAWIPKMRWAKSDAEVDLVRESARWANLAHRYLADYTEVGAHPATVSQRASMDGSRAMLDALGEEYVARTRGDGPVHAGYITDEQTALPHGHTANRRLEPGDVMITGATANVDGYFSELERTMFLGEPGEEQRHYFELATEAQQLAIDALGPGVEISYVDEVVAEYFEEQGVADLARHHVGHNIGLDGHEPPYIDLGWSEHCESEATDYDPDDATMESGMIWTIEPGLYTETAGYRHSDTVAVTEDGIDRLTTFPRSIEGNTIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0V2</accession>
    <name>R4W0V2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps5p</name>
        <name evidence="4" type="synonym">rps5</name>
        <name evidence="8" type="ORF">L593_11205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447080.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11205"/>
    <dbReference type="EnsemblBacteria" id="AGN02186">
        <property type="protein sequence ID" value="AGN02186"/>
        <property type="gene ID" value="L593_11205"/>
    </dbReference>
    <dbReference type="GeneID" id="16182539"/>
    <dbReference type="KEGG" id="sali:L593_11205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2311"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OrthoDB" id="60954at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="216" mass="23521" checksum="066A3F428DECDAE4" modified="2013-07-24" version="1">MSGDNYNDDGWEPVTRLGRQVQEGEIDTMEDALNSGLPLKEPEVTDRLLPGLEDEVLDINMVQRMTDSGRRVKFRCVVAIGNRDGYVGYAEGRDDQVGAAIQKAIEIAKLNIIDVSRGCGSWECGCGRPHTVALRTEGKAGSVTVELQPAPRGLGLAGGETPRKVLELAGIEDAWTEASGNTRTTVNFAKATFNALRKTAEARVPEYAFEQREVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W166</accession>
    <name>R4W166_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447200.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11815"/>
    <dbReference type="EnsemblBacteria" id="AGN02306">
        <property type="protein sequence ID" value="AGN02306"/>
        <property type="gene ID" value="L593_11815"/>
    </dbReference>
    <dbReference type="GeneID" id="16181537"/>
    <dbReference type="KEGG" id="sali:L593_11815"/>
    <dbReference type="eggNOG" id="arCOG03131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039905_0_0_2"/>
    <dbReference type="OrthoDB" id="27984at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="289"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="503" mass="53548" checksum="389D23CEF978B7C9" modified="2013-07-24" version="1">MQHGRLAVVDSDALDGLATAQLRDAIAATDPHALLATTPNTRIRLRSALPEFDRPVVAPGSDQAGGELSIGAVGDVQVAVAGSTASVADLAALETAGEIDATTHTYVLTDALDLSVRPTELRTVRQGVAAYRRAIATGERDADHALRGSYTHLSTNLPTDYYGEWGELTVRGVAPGSIDGAPSGGPGSTETAIASLELGVDGTVSSGDLRAASLGLRAIDGVGEQRARTLREAGYPDREALAKADVATLADLDDLARSTATSIVNCARAFEAGRVRRRTDERLPGPEPIFVDIETDGLSPSTAWLIGVLDREADQPYRSFLAADPDRPVEALESFCAWYAERVDQGSQRPLVAYNGQPFDFPVLAELIEMHCPEYRTVWADAWTFDPYAWAIRDGNASFPARTNRLEDVATALGFDDGETTKHANALPLDGAEVARVYRTWQADPSPETEPDWEALEAYCEADVRALAHVYDAIDAADRTAGDSGGAVREPTAETTQGSLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1T2</accession>
    <name>R4W1T2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447505.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13360"/>
    <dbReference type="EnsemblBacteria" id="AGN02611">
        <property type="protein sequence ID" value="AGN02611"/>
        <property type="gene ID" value="L593_13360"/>
    </dbReference>
    <dbReference type="GeneID" id="16182468"/>
    <dbReference type="KEGG" id="sali:L593_13360"/>
    <dbReference type="eggNOG" id="arCOG09029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607119_0_0_2"/>
    <dbReference type="OrthoDB" id="91750at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="20527" checksum="83297E8A150287CB" modified="2013-07-24" version="1">MVWVKSEYAGELAVVSAWLSVLLPWYTSYVPEIDGLPGSVLFLRFPLAQIRFTFGVPFAEAIDVRTPMGIVVQRADTLESGAIEIAYWVWYVGAALVVLAVVLSVVMYVEYEQVLDALPVHPVRVMGALLTGAGLVLALSTGLFYRHRVFEEYPVPIGLVVMLLLGGSLLRVELLEDEQATDASEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2A8</accession>
    <name>R4W2A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent oxidoreductase/NADPH2:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_14285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447690.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14285"/>
    <dbReference type="EnsemblBacteria" id="AGN02796">
        <property type="protein sequence ID" value="AGN02796"/>
        <property type="gene ID" value="L593_14285"/>
    </dbReference>
    <dbReference type="GeneID" id="16181177"/>
    <dbReference type="KEGG" id="sali:L593_14285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2924"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_2"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="35646" checksum="FB90F13EEBBE22D0" modified="2013-07-24" version="1">MRAAVLHEPDRIELEDREAPAPGPDEVVVDVGAIGICGSDLHYYEHGRIGDYVVESPLVLGHESAGVVAAVGSDVESHSVGDRVALEPGVPCRRCEYCRSGRYNLCPDVTFMATPPDDGAFVESVAWPADYAFTLPDAVSLTEGALAEPVSVGVHACRRGDVGAGDSVLVTGAGPIGLLAADVAEAFGATEVTISEPVDRKREIAADRGATRTVDPVADDVQSAVGGTGDGGPDVAIEATGDPAALQDCIDSVRRGGTVVCVGLGAESELSLDVVDLVDDELTLAGCFRYANTYPTAISLLADGQIDAAGLVDFEAPLEETADAMERALDPTLVKGMIEIDEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2N9</accession>
    <name>R4W2N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444951.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00510"/>
    <dbReference type="EnsemblBacteria" id="AGN00057">
        <property type="protein sequence ID" value="AGN00057"/>
        <property type="gene ID" value="L593_00510"/>
    </dbReference>
    <dbReference type="GeneID" id="16181698"/>
    <dbReference type="KEGG" id="sali:L593_00510"/>
    <dbReference type="eggNOG" id="arCOG03116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_1_1_2"/>
    <dbReference type="OrthoDB" id="94423at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="18562" checksum="650479AAA75956D3" modified="2013-07-24" version="1">MQRRAGIVLAIGVALIVGLLAAGVTLYESEDTTSGNVVLYDGDERIATINASVADEFQEQYVGLGDHDDLADDEGMLFVYEHPANRTFVMRSMAFGIDIIYVDSEGCITSVNPAPEPGPDENGEDQEYPGYGQYVIEVPIGVASDAGVERGDPVRIEYGNTTVDGRGTDCFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3B7</accession>
    <name>R4W3B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein PaaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445326.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02405"/>
    <dbReference type="EnsemblBacteria" id="AGN00432">
        <property type="protein sequence ID" value="AGN00432"/>
        <property type="gene ID" value="L593_02405"/>
    </dbReference>
    <dbReference type="GeneID" id="16180189"/>
    <dbReference type="KEGG" id="sali:L593_02405"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.488"/>
    <dbReference type="eggNOG" id="arCOG04786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070585_1_0_2"/>
    <dbReference type="OrthoDB" id="82021at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02158">
        <property type="entry name" value="PA_CoA_Oxy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="31489" checksum="6460FA6FFC9B5AA6" modified="2013-07-24" version="1">MAEAASPQLHLDDLADREREAVEALLFRLADDELVLAERYTEWQVRSPTLESDIALANIAQDELGHARLWYQLLQRFEYDEPDLIYERDAGDFRHSTLAELPFPEGDWADAIVRSFLYDVAEDVRLHAIQESSVPAIRDRVEKVLQEEDYHLDHAHSWLERLAGVEDGHGRLQAAVDRLFPHALTLFEPVGDVETAIDELGIRDRSLDEMREEWLTRVGGTLEGLGIEVPAAEPADPAGRDGEHTEHWEPLHAEMVETYHDLGRDSATTIMEPDDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3R0</accession>
    <name>R4W3R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dithiol-disulfide isomerase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445586.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03705"/>
    <dbReference type="EnsemblBacteria" id="AGN00692">
        <property type="protein sequence ID" value="AGN00692"/>
        <property type="gene ID" value="L593_03705"/>
    </dbReference>
    <dbReference type="GeneID" id="16180667"/>
    <dbReference type="KEGG" id="sali:L593_03705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.752"/>
    <dbReference type="eggNOG" id="arCOG02869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_2_0_2"/>
    <dbReference type="OrthoDB" id="63960at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="23672" checksum="00FF412C4DD31934" modified="2013-07-24" version="1">MSDDSDQLLVYADYVCPFCYLGRESLAQYQDDRVEPLSVAWHPFDLRSQKRGPDGEIDDSVDDGKDDAYFDTVRDNVARLRDQYDADQMLGIDEVPDVDSLDAQVASLFVQREYPEEWPAFDDALYRALWEGGEPIDDPDVLADLAEDVGVDGEEVRDAIEDDERRAEVFEQFEAATQEGVTGVPTFAYEGYAARGAVPPEQLRRLVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4A6</accession>
    <name>R4W4A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445906.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05315"/>
    <dbReference type="EnsemblBacteria" id="AGN01012">
        <property type="protein sequence ID" value="AGN01012"/>
        <property type="gene ID" value="L593_05315"/>
    </dbReference>
    <dbReference type="GeneID" id="16181317"/>
    <dbReference type="KEGG" id="sali:L593_05315"/>
    <dbReference type="eggNOG" id="arCOG01140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129109_0_0_2"/>
    <dbReference type="OrthoDB" id="108707at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="15629" checksum="25BDF298C5B35956" modified="2013-07-24" version="1">MVETCYVTGGLLDALLAIAGDREPDAVSTLLVVSRAGELDELPASEDDDLDPETPVFTDLYFPSAGRSVDAVFGMDVSVPHGQAQGRFVSHPLGELSVSNTDDLHEVVLVAVPPWTREDVAAFDRSGRRLELRIVAAAPPEQPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4K7</accession>
    <name>R4W4K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446086.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01192">
        <property type="protein sequence ID" value="AGN01192"/>
        <property type="gene ID" value="L593_06215"/>
    </dbReference>
    <dbReference type="GeneID" id="16181661"/>
    <dbReference type="KEGG" id="sali:L593_06215"/>
    <dbReference type="eggNOG" id="arCOG06816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878852_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="32358" checksum="62783F37E998BECE" modified="2013-07-24" version="1">MRRRDLLVGTGGLALSALAGCLGSARETLAERPPENAVVDDLRTAIGEANTVALQLATAREDAATPADVSFDREALESGLATSRQALDEAAQREAADDYEAEIPAARSYVDVVAGLLTGSASLADAAGELQRVESSIANGDYQAAGQTLNSIQPVVGDARSTVTDAESTANAIDPAVLDPYGAKMGELTDGLTTVQNIAVGADELTGGYDAILTGRGHLESGQVAVQQGNFATAESEFQAAKSAFQTATGHFQTARQETDGELQSQIDTALCRSQALTNAAAHFEASAVAAQSGDLATARDERNAGEADISAAGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4S8</accession>
    <name>R4W4S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446206.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06825"/>
    <dbReference type="EnsemblBacteria" id="AGN01312">
        <property type="protein sequence ID" value="AGN01312"/>
        <property type="gene ID" value="L593_06825"/>
    </dbReference>
    <dbReference type="GeneID" id="16181889"/>
    <dbReference type="KEGG" id="sali:L593_06825"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1394"/>
    <dbReference type="eggNOG" id="arCOG01267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OrthoDB" id="71557at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="24462" checksum="5C69D6C5B05C4AC8" modified="2013-07-24" version="1">MSVSFDFEDTVALVTGASGALGSAVVEQFRATGAAVAAIDVIAPDDEDSLLDPDEGTTFYEADLTNEDSVAETIDAVVEDHGRIDHLANIAGTWRGGDPIEETDLSTFELVFDVNLKTMFLTSKHALPHLQESGGAIVSVSARSSLEGGEGDGPYRASKAGVRLLTETIAEENRGTVRANAVMPSVLDTPMNREMMEPSDDWVDPGNVAATIAVLCSDATVVTSGAAVPVYGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4X7</accession>
    <name>R4W4X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446286.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07225"/>
    <dbReference type="EnsemblBacteria" id="AGN01392">
        <property type="protein sequence ID" value="AGN01392"/>
        <property type="gene ID" value="L593_07225"/>
    </dbReference>
    <dbReference type="GeneID" id="16182193"/>
    <dbReference type="KEGG" id="sali:L593_07225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1475"/>
    <dbReference type="eggNOG" id="arCOG04723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104046_0_0_2"/>
    <dbReference type="OrthoDB" id="69792at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043868">
        <property type="entry name" value="DUF5828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19146">
        <property type="entry name" value="DUF5828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="26201" checksum="997C5759F3925CC7" modified="2013-07-24" version="1">MEERVSGFRVTGDWPAIVEHGERVTRALRDLDVNGDSPYAADFEEWEEWRPKAHERIEEDVPEKTAEQASVGEGEGEKAGSTPGEDVKTAGDKLSESYEKLEDDGDAAGAREAWGESIDYVARAADSAGRKALRVVEDTVYQRVMTQLAPYYFDNALISANLQQSGRDDDTFVFEVNVNDDELKSEVGDRLRDYEDEVDRWHVDTEKETAHVEAAEGVETPTENENGRSKHTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Z1</accession>
    <name>R4W4Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446311.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07360"/>
    <dbReference type="EnsemblBacteria" id="AGN01417">
        <property type="protein sequence ID" value="AGN01417"/>
        <property type="gene ID" value="L593_07360"/>
    </dbReference>
    <dbReference type="GeneID" id="16182103"/>
    <dbReference type="KEGG" id="sali:L593_07360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1503"/>
    <dbReference type="eggNOG" id="arCOG02177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718876_0_0_2"/>
    <dbReference type="OrthoDB" id="32299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40700">
        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="40545" checksum="87FAA8DD78BD4D60" modified="2013-07-24" version="1">MDDLFDRIDPEKAWALVVAGLALAGTLGSLLFPKQVYDQWIWKYYWGPVAADGNGAKCAVRESGDVTYYSDSAQCAGASGIVAEPGYTVISTISYALLLVLLLAGVYFLVERLDIDAKVTALYALFPWVLFGGALRTVEDASVALLSATGDPAIPFPWTAAIISPFIYVTVFLLAVIAITASVWLERDGRVDRWERPFGAAGAVLFLLALGSLVYLSVTTDAVGFNLGVLVVTVLGATLATALAWTLTEEYWPEVNVGTGTVGLLVVWGHSIDGFANVISLDWSDEFGLAYDYDPKHVVNSGIQDATRAIQPESVSDAIGVTWPFIPVKVVAAVLVLWLFNDEILEESPRYAVLMLLAVLAVGLGPGTRDVLRATFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Z4</accession>
    <name>R4W4Z4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S74 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Harcht-Bsk1</strain>
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        <source>
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    </evidence>
    <sequence length="471" mass="47139" checksum="8B3AF666D6E27B3D" modified="2013-07-24" version="1">MTGDDTTAADDAANDGAEPDRIERLERTVETLAERVVELETERAATASGGGVVSRRSVLGALGLAGLAGLGATTAAGDPQGQIGTSNDPLRALNVETINAGLASTQFELSVGGSRALHLGQEEQTQSLAGSVVLGHSNNGASGPCATISGGGRAGAPHDAGRRAAVGGGTGNEATGNAATIAGGITNDASGRQTAIGGGNGNTANSLQATISGGRDNTASGEGATVGGGVLNEASGDYAVVPGGEANSAAAPHSFAGGTHASATHEGAFIWSDTSSGGLTTLNPDEFAVLASGGTFFFSNAGATTGVELSSGSGSWSSASSRTLKSDVEPVAGEDVLERVTDLEISRWSYDSQPGVRHMGPMSEEFHEAFGLGDDEEQISTVDADGVAFAAIQGLAERNEETTERVETTSDRIDELEAENEALRSELQELRAEVEFVQNAMVAADGGMPKESTVTTGEGDAGDPESGGEGQ</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="420" mass="43848" checksum="4E86EE1AEA02BC7B" modified="2013-07-24" version="1">MELRRGTVRRAAAIALTALLLASLLPGLAVGDATTGTTTAGATTAETGPLASTNASTAIQEVDADRTRIRIDLQEDGDATWTVELWTRLEDDADEEAFASLEADVRNDSESYTADFRSRMNGSVTAASDATGREMTIEGLTVSTRTEGVPSSYGVLAYEFEWTNFAVVDGQELHAGAAIDGFLMEQHTRLTISWPEGYRTASVEPSPNDRTDSAAIWQGSETDFVAGQPRLVVTSAAAEDDSLLPLVGAAVLLAAIVALVGYLAWSGHLSLPGSSGREADGEVAIADSGGAGAASASAGAGAAPTDDDSSHEATGASEAPSDADGAAEEQPGDGEPTAEADEPAEDEADVPPELLSNEEQVLRLLEGHGGRMKQQQVVSELEWTEAKTSQVVTGMREDDRIEVFRIGRENVLALPGEADL</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01627">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG00134">
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="415" mass="43640" checksum="93A0EE7F631E047A" modified="2013-07-24" version="1">MSDAESAEASQPETTPKDDVNRANRLRWTAVIFAALAIGGGAMMARGPVIPELETAFGAPEWQLGLIAPAGTLGYLFAVTFVGFGAGHLRARLLIAGGLVGNAVALLALGAAPILLVFLGAVVVQGAMMGVVRGLNRPLLSHFYPSRRGRIYGYYDMTWAAGAALAPVLVVAVVALASWRFVFWIFAVLLLGLGVVVWRLDEPAVETQEEPLAREDVLSLLRRPEVLGMALVMFFATGVEGGLFLWLPTYAESQLPSWIAGVTLSIMIAGYVPGRFVYGRLSERVGYVRLLVAILGLLVPVFVVTFTLAEGLWLLPGILAIGLLISGAFPLLVSYATDAAPEYSGPVTAVAAISSSLGVGVMPAIMGFAISDADPVLGMQLLLIPLGLALVTIVIARIAEVRRTPTDDAACASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5E6</accession>
    <name>R4W5E6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Putative enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
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        <property type="protein sequence ID" value="AGN01687"/>
        <property type="gene ID" value="L593_08710"/>
    </dbReference>
    <dbReference type="GeneID" id="16179819"/>
    <dbReference type="KEGG" id="sali:L593_08710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1785"/>
    <dbReference type="eggNOG" id="arCOG07503">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_038823_2_2_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="1">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="38117" checksum="5D094774A7043728" modified="2013-07-24" version="1">MALRLGLTGDVMLGRLVDEAQQDRPPTAVWGDVLSQLRDLDGLLLNLECCLSTRGTKWRRTRRAFHFRADPDWAIPALEAAGTSYCSLANNHVLDFEEPALFDTLDHLDEAGIPHAGAGRTEQEAFAPATFEIGTADEVAEEGTEPEAPEPLSVAVVSLTDNTPEYAATATSPGTAHVEIDVDDAETRAAVESAIERANAADPDLLVASLHWGPNMVAEPPERFRRFAHWLVEQGVDLLHGHSAHVVQGIEIYEGVPILYDCGDFVDDYAVNQTLRNDRSFLFEARVDVEDRSITALHLTPTEIENRAVRVASPATAQWLRETIRDRSDGLGTSFVRHGEGLVVPVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5S0</accession>
    <name>R4W5S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_00040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444857.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00040"/>
    <dbReference type="EnsemblBacteria" id="AGM99962">
        <property type="protein sequence ID" value="AGM99962"/>
        <property type="gene ID" value="L593_00040"/>
    </dbReference>
    <dbReference type="GeneID" id="16182552"/>
    <dbReference type="KEGG" id="sali:L593_00040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.8"/>
    <dbReference type="eggNOG" id="arCOG02099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_2_2"/>
    <dbReference type="OrthoDB" id="110491at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGM99962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="230" mass="25697" checksum="29BEC6A7901DF277" modified="2013-07-24" version="1">MMLSDVMEDYLKAIYYLQGEDEEGERIRTSAIADHLDVTSPTVTSMLEKLEDRGLVDREKYKGVRLTDEGETVALEVLRHHRLLEAYLTEHLDYDWSEVHDEADRLEHHISEKFERRLADILDDPEVDPHGDPIPNEQLEPPAAEVGIPLTEYDPDDRVAVARIEDGDPEILRYLAERGIEPGAVLEVVDVAPFGVVTVRAATASDTCALPEDVAGEVLVTSVVEEIEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5T9</accession>
    <name>R4W5T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444887.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00190"/>
    <dbReference type="EnsemblBacteria" id="AGM99992">
        <property type="protein sequence ID" value="AGM99992"/>
        <property type="gene ID" value="L593_00190"/>
    </dbReference>
    <dbReference type="GeneID" id="16181043"/>
    <dbReference type="KEGG" id="sali:L593_00190"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.38"/>
    <dbReference type="eggNOG" id="arCOG00605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118194_0_0_2"/>
    <dbReference type="OrthoDB" id="72918at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dus" evidence="1">
        <location>
            <begin position="79"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="254" mass="27098" checksum="2F09EB44167424B5" modified="2013-07-24" version="1">MGPDVSFSPRVAVASLSGQSDATWATNALPHVGAAFLGGIALDEPTREGARELVERDREEFLPDDPIGWIDEQLATLADEPLLPAVNVRAASPEPIADAARRCAAHDAILEVNAHCRQPELCAVGTGQTLLREPERLANYVDAATTEGATVSVKLRTELADVDLPVLASRLEVAGADVLHVDAMDSEPEIADVVEATDAFVIANNEVRGRESVREYLEYGADAVSVGRPSTEPAVLERVRSATEAWFEAEQVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W670</accession>
    <name>R4W670_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_11010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447041.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11010"/>
    <dbReference type="EnsemblBacteria" id="AGN02147">
        <property type="protein sequence ID" value="AGN02147"/>
        <property type="gene ID" value="L593_11010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180793"/>
    <dbReference type="KEGG" id="sali:L593_11010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2270"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OrthoDB" id="87520at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="40283" checksum="C028A79D3D8B3553" modified="2013-07-24" version="1">MSQQSSDRTEGDLRNTGMSLKHDREWDYELERIEAAVEERDADTVGLQFPEGLKRRGPAVADDIRDLIDADVTVLLSGQPCYGACDLDTFLMKRSDVFVHFGHSPMKESEKIIYVPLFSNVDPFPIMEESLAELAPPTEDDAEPDESADPDVGLVTTAQHMNRFEEMTEWLEERGYSVHTRKGDDRLTHEGQVLGCNYASAEVDADQVLYVGGGKFHPLGLAMEHPEKTVVIADPVNNVVTVADTEQFLKQRYASVHKAMDAQKWGVIYCTKIGQGRWDQAEAILEDNDDAYLITMDEVTPDRLRNFDMDAFVNTGCPRITTDDGPQFHKPMLTPGEYEIAVGNEPLDSLSFDTFHGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D1</accession>
    <name>R4W6D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00308">
        <property type="protein sequence ID" value="AGN00308"/>
        <property type="gene ID" value="L593_01785"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.362"/>
    <dbReference type="eggNOG" id="arCOG00381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048695_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="39013" checksum="91BB4C582F779015" modified="2013-07-24" version="1">MALGGPVAGGSLASGSVAGLPAVGTAADGSTLPQHSPASTLAAQSDDVSFVSLQDQPEADATVTRIVLHENGSAIWTIEVRTRLTSAEEVAAYESFQERFRSNRSRFREEFEARMTGVVESANGSLDRPMRATAFSASTSIEEAPQRWGVVTYTFRWEGFAATEGDGLVVGDVFGGNFFIEENSVLEFVLPEGHEVETVSPSPDSRSGETMQWEGPASFGDGQPRVVTTTGDDGLSLVWILVAAIVVLAALLALAIAWRRGSIGGRADESETAAASAGDEPEGGDATAAEPGPLTDEDRVREVLEAHGGRCKQSQIVEELDWSKSKTSRVLSRMAEENRVEKLRIGRENVIELPGKERAPTADFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P9</accession>
    <name>R4W6P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445402.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02785"/>
    <dbReference type="EnsemblBacteria" id="AGN00508">
        <property type="protein sequence ID" value="AGN00508"/>
        <property type="gene ID" value="L593_02785"/>
    </dbReference>
    <dbReference type="GeneID" id="16180471"/>
    <dbReference type="KEGG" id="sali:L593_02785"/>
    <dbReference type="eggNOG" id="arCOG08186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527493_0_0_2"/>
    <dbReference type="OrthoDB" id="108138at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="516" mass="54995" checksum="9F50982456EE89E0" modified="2013-07-24" version="1">MKLPGSDRPLLADFYPGAWLVLLAPIAFGIYELQAKFAPTLVPPGVAPAEQVGVNYEVYYYAADALLEGQHVYDVSPPGEGEFYEYLYPPITILVFLPTLLVSPTSGYWLFLGLNGLAAAALTVFAVRYVEDLGRPLGWLDVALVFAFCYGCSQMVTNAYFGNVNLLLGTGVAAGLYLLEVGDRTPRRESIAGACFAVVALFKLFPALLGLYLLRIRAWWATAAAIAVGIGGLLAGELLFAVGGLFGWETGDGPLGFGMTVRWLQEAILPRGDTHLFVGGLPPDAFFYVTIQRPLSHVLYGIVPGTPAWLAPVLVAGSFAIGLAVAIAALRRLDTRFDRLVAAFAVASVAILVMPSLQYYVALSFLPIVVLAYLLDGHPFQPLFVVGGIVLAYAVWPAGVLDRLDDAPAVVQVLLDPIAATTSTQLLGLAIMLLACGLVRRRGGDAASIPARALEPRPAGPPLRRWFADRGVELPGSWDPTRGWSVGATDAAPAPESDRAPNGRSQVVDADGRKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q5</accession>
    <name>R4W6Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445412.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02835"/>
    <dbReference type="EnsemblBacteria" id="AGN00518">
        <property type="protein sequence ID" value="AGN00518"/>
        <property type="gene ID" value="L593_02835"/>
    </dbReference>
    <dbReference type="GeneID" id="16182702"/>
    <dbReference type="KEGG" id="sali:L593_02835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.573"/>
    <dbReference type="eggNOG" id="arCOG01388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077872_0_0_2"/>
    <dbReference type="OrthoDB" id="42474at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="297" mass="32146" checksum="01E9B31EE9165141" modified="2013-07-24" version="1">MELSVVVPTLNGRDQLGGCLDALAEHVPEAEVVVVNGPSADGTTGMVSERGDVETLVEIADRNVNAARNAGFEAATGDTIALLRFDRVVDESWLDALEAGLESGADVVTGPTRTTLEGIEEPAQSIAGRSVTFCNGENVVFSREAIEALDGFDEYLEVGGSRDASHRLAGLDYEVEWLPELSVHSQYGADGGEPETDRRARYRSLAYQLVKNYGLRPSIVIRSLRDATADAVGAARSVLDGDGRFTSWFGHGRAAIAGLSVGAKDGWRARRRDRSRRRNPNGISARADRVVQRYDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z6</accession>
    <name>R4W6Z6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="DUF5786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19099">
        <property type="entry name" value="DUF5786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6531" checksum="EE221A8219617569" modified="2013-07-24" version="1">MGFGSYDESEQSDRDHDTDDDQAVSVHEHDHDGEVSFENDSPTSDLVDRLSEMGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W732</accession>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="61" mass="7171" checksum="6594D93518374811" modified="2013-07-24" version="1">MNINNVPSRYRYFSHVQIIIIPLSPLKYSIVELGIQREKQMIGISDLATPFLKIYMARFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W791</accession>
    <name>R4W791_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_04410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04410"/>
    <dbReference type="EnsemblBacteria" id="AGN00833">
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        <property type="gene ID" value="L593_04410"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_04410"/>
    <dbReference type="eggNOG" id="arCOG02768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="59035at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
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        <property type="entry name" value="Rce1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="31144" checksum="394B006F7B832620" modified="2013-07-24" version="1">MLDRLARTVGGHPYGDLFGFFAFSHGWTWAFWGVNVVGGLDAFGAGLPFTVLGGVGPMLGGIAMAYVTYGGVGLADLRRRLTDTAWLRSSWALLVVGLFPALVVATGLVIAIATDASQPLDASELVALLGDPVALVGTTVVIVLVGPLPEEIGWRGYLLDRCQRRWSALASGLFVGLVWALWHAPLFVMPGYYANFDYSPTPIWFATSIVLGSVLYTWLFNNVARSVLAMIVLHTSGNFAGQVTEVPPVGEPIGVAVRAGLVVAVVALFGAGSLRRTGSAPEPPQERSVVHDPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H4</accession>
    <name>R4W7H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crcB</name>
        <name evidence="7" type="ORF">L593_14890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14890"/>
    <dbReference type="EnsemblBacteria" id="AGN02912">
        <property type="protein sequence ID" value="AGN02912"/>
        <property type="gene ID" value="L593_14890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14890"/>
    <dbReference type="eggNOG" id="arCOG04701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="13257" checksum="CD4FF69314DDA38E" modified="2013-07-24" version="1">MVIEAAYSHSVLSGGLSPALLVGVGGAAGALTRFGIGELVGLDHFPISVMVVNAIGTFLATLLVLLAPGRDAVLVASVGFCGSLTTFSTFSVRTVTLWREDRPLAAGTFALGTLLASLFGVGLAVVLVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7I9</accession>
    <name>R4W7I9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulatory protein L593_15015</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_15015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447831.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15015"/>
    <dbReference type="EnsemblBacteria" id="AGN02937">
        <property type="protein sequence ID" value="AGN02937"/>
        <property type="gene ID" value="L593_15015"/>
    </dbReference>
    <dbReference type="GeneID" id="16181629"/>
    <dbReference type="KEGG" id="sali:L593_15015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3066"/>
    <dbReference type="eggNOG" id="arCOG04152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075726_0_0_2"/>
    <dbReference type="OrthoDB" id="76134at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arc_TR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="321" mass="34970" checksum="7BAECAF6A8FB0901" modified="2013-07-24" version="1">MSRSALVGNVIAMLEDAGFAVSDRCAIRPRSFDLAARRGEELLLVKVLRNVDAFDAATGEEMRRIGSWLDATSLVIGLRTRDEPLKPEVVYLRHGVPVLSPDTALDLFVEGVPPLIYAAPGGLYVSIDSDVLADEREERGWSLGRLANELGVSRRTVSKYEDGMDASIEVAAQLEELFGGGLTSAVDVMGGAEQIRDAEPTPDAPDADPDDQPMVAVMHRTGYRVHPTIRAPFKAVNEDDDGETEIILTGHSEFTQSAEKRARIMASVGEVAETQSVYFVDSTKRESVGATALIEREEAEDIEDADRLRDLIRERSDAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R0</accession>
    <name>R4W7R0_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05895"/>
    <dbReference type="MEROPS" id="S26.A11"/>
    <dbReference type="EnsemblBacteria" id="AGN01128">
        <property type="protein sequence ID" value="AGN01128"/>
        <property type="gene ID" value="L593_05895"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_05895"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1207"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="387" mass="40088" checksum="E8E1CADE233AB6ED" modified="2013-07-24" version="1">MTAREWAGRIASAVLIVVILSLVVGHLLGTPILLGYVSSNSMEPTIDQGDGFVSIPQPLAGDVEEGDVVVYRARELDGGGLTTHRVVEVTDEGYVTKGDNNPFTDQDGPEPIVRDEQVEAEALRIGGTVVTIPHLGTVVGGIGSVAGGVRSGLANTLGLGAATSPRGFGLLLVGLGLALVALASGGGGRGVRVTDRRTDREHVIKLWSAVGAVAIVVVLLATAAMVIPGGVQEFGVASQGDPSSDPLSVEPGGTAEIEYPVNNAGLVPTVAIVEPHSSDVDVQPDRVTVGGRSTETATATIQAAEQEGIHYRHVSEHRYIMVLPPGMIEAAHDVHPVFAIVLIDLVVGGLVVLAGVALLGTDDIRVRPGGSGRPLTEQVRRAVFRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T5</accession>
    <name>R4W7T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00049">
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        <property type="gene ID" value="L593_00470"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11032" checksum="FDEC7A08CA092CE3" modified="2013-07-24" version="1">MIQMDALTTAVVAANTVTLVFGSAIVLLAYRAYARTGSRALRALSAGLGLVTLGTLLGGTLHQLTASSLLQSIVVQSGFTALGFVVLAYSLFVERTPTPTVVSSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U0</accession>
    <name>R4W7U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-sulfoglucosamine sulfohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00570"/>
    <dbReference type="EnsemblBacteria" id="AGN00069">
        <property type="protein sequence ID" value="AGN00069"/>
        <property type="gene ID" value="L593_00570"/>
    </dbReference>
    <dbReference type="GeneID" id="16181776"/>
    <dbReference type="KEGG" id="sali:L593_00570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.116"/>
    <dbReference type="eggNOG" id="arCOG02785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_7_3_2"/>
    <dbReference type="OrthoDB" id="25689at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="461" mass="51631" checksum="51BA46FCC382B3B8" modified="2013-07-24" version="1">MGDPHAADDAPGPNVVLVHCHDLGQYLGCYGADVESPNLDGLADEGVRMANSFCTAPQCSPSRSSMMTGAYPHENGVMGLAHMGWALDDDWMTLPKYLREAGYSTHLLGFQHEVPDDPERLGYDHVDDDTKRALELVDVVDEFFEARVEDGQHADEGEPFFVSIGIEEPHRPFRRDYLPESIYDEPSPEAVEGFPFLPDAPGVREDTAALQSLIAETLDPAIGEFRQALADAGLAEETLFVFTTDHGLAMPRAKGTCYDPGLETALLFYQPERIEGGAVHEELVSNVDFTPTILDLVGVEPPTDVAGRSFAGLLVDENEDETDVTTYDPRDRIFGEMTWHDRYNPVRAIRTERYKYVRNFSVLPRIFVPMDVVPTPSGREVHEEFYVEQRPEEELYDLEADPTEQENLASDRTPYEPTSAASDPDPEHREVLETLRTELREWMERTDDPLLDGPVAYPPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W2</accession>
    <name>R4W7W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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        <property type="protein sequence ID" value="AGN00119"/>
        <property type="gene ID" value="L593_00820"/>
    </dbReference>
    <dbReference type="GeneID" id="16182205"/>
    <dbReference type="KEGG" id="sali:L593_00820"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.168"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031172_0_0_2"/>
    <dbReference type="OrthoDB" id="46757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="424" mass="45778" checksum="EAA16B3CB5328EF2" modified="2013-07-24" version="1">MSLDDHAEDLASDLGVDKEEVKADLENLVEYSVPVEEAKESLRRKYGDGGGGGGSTPSVDSIAEIDTETGSVNLTARVLTIGDREISIDGERQVIREGDLADDSGKIEYTAWEDFGLEAGDTITIGNAGIREFRGNAQVNLGSSTTVTFEEDDLEVPYEIGPDRSLADLQVGDAGRAVEVLVEEVETRTIDGRDGETTIKSGVFGDESGRLPFTDWGNRDDLEEGTTIRAENVHVREFRGVPEVSLSERATVQPIDRDIEVGEEVTRRSIREAVATGGIYDVEVVGNVVDVRDGSGLIERCPECGRVIQNGQCRSHGQVEGEDDLRVRAILDDGTDTVTIVLGPDKTEEIYGGGLEKAREAARDAMDQSVVGEQIASEIVGREYRVRGHLSVDDYGATLDASEFEETGDEPADRAAELLAKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y5</accession>
    <name>R4W7Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446212.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06855"/>
    <dbReference type="EnsemblBacteria" id="AGN01318">
        <property type="protein sequence ID" value="AGN01318"/>
        <property type="gene ID" value="L593_06855"/>
    </dbReference>
    <dbReference type="GeneID" id="16181902"/>
    <dbReference type="KEGG" id="sali:L593_06855"/>
    <dbReference type="eggNOG" id="arCOG02499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540397_0_0_2"/>
    <dbReference type="OrthoDB" id="67963at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="342"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="504" mass="52771" checksum="34A53A6F78C42D7F" modified="2013-07-24" version="1">MTDHADVPTTACNRRTAARLLLGGSLVGLAAGVGSASADSGTGPATLAFHTQSGRRVDYAFEATGDVRPLDHAPHLDVPDDSVSTDRGTTIENGVVTGAIDGGYDVFAYEGHLAAFAIIDGNCAALRLWDSGESVAPCELEDRLPSPHWGTRGDPTVVEGCTTIDEPGYYVLGRDVSTCDREVCIEITADDVLLDGRGHAVEGDFEGVGVRVTGDDAVVRDLAVVEWDVCLQVRGDHALIQGVSLANGDRVFEDEPGDDRTIGLAVEGATGCTVRNVEIYAGREGAKLTSSPDAIVVDSSIEGGGIEATTGDDDRTEAVVLRESPDAILAGTECIGFLFGCLVDGSDRVVLRDSRFQSADFGLSGLRLLDCGDPTLLDNFSSGFQPIDLVDVTDGVLRGNRVRSTERYGIQIERGSNNVLFQNDASDNQEGPGIQLVDTAENVLVGNTIRGNNVLGPGGGLVLIDAVDNVAVRNEICENGGEQILVEGASSGNLFIENDTTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y9</accession>
    <name>R4W7Y9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446222.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06905"/>
    <dbReference type="EnsemblBacteria" id="AGN01328">
        <property type="protein sequence ID" value="AGN01328"/>
        <property type="gene ID" value="L593_06905"/>
    </dbReference>
    <dbReference type="GeneID" id="16181924"/>
    <dbReference type="KEGG" id="sali:L593_06905"/>
    <dbReference type="HOGENOM" id="CLU_1607224_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="165" mass="16576" checksum="A499C88E3F75C98D" modified="2013-07-24" version="1">MDADWEGVSRTGKATVTGGALVALGTVLPYMSYSGGSASLLQDGKMEVVLSNGMSAGTATVASSETFLFALVLAAIAIGLPLLRGWDWKSSLPVFLVGAFDALLFGYSALMLHGGDQDAALVGGEPVAASATPGIGLYAAIAGTLVVTVLSLGNLLSTVLGRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W864</accession>
    <name>R4W864_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445253.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02040"/>
    <dbReference type="EnsemblBacteria" id="AGN00359">
        <property type="protein sequence ID" value="AGN00359"/>
        <property type="gene ID" value="L593_02040"/>
    </dbReference>
    <dbReference type="GeneID" id="16181686"/>
    <dbReference type="KEGG" id="sali:L593_02040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.415"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="27475" checksum="21B6B848E35A0133" modified="2013-07-24" version="1">MSILEQFRLDGKTAIVTGGNRGIGRAIAEGLADVGANVVVANRDGEAGDEAAAEIADDYDAETLAVETNVTEEAAVEAMVEATVERFGGVDVLINNAGIVHHNPVEEKSVEEWEHTIDVNLTGAYRCAKHVGEVMRENEDGGVIVNVSSMSAFIANYPQHQVDYQASKGGLEAFKNQLASEWAEDGVRVNNVNPGYVFTDNIVHDGDVVETWRDEMLVEEFAEPDDIAPLVVYLASDASGYVTGESVVIDGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W871</accession>
    <name>R4W871_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_02140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445273.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02140"/>
    <dbReference type="EnsemblBacteria" id="AGN00379">
        <property type="protein sequence ID" value="AGN00379"/>
        <property type="gene ID" value="L593_02140"/>
    </dbReference>
    <dbReference type="GeneID" id="16180085"/>
    <dbReference type="KEGG" id="sali:L593_02140"/>
    <dbReference type="eggNOG" id="arCOG02601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996121_0_0_2"/>
    <dbReference type="OrthoDB" id="77353at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040726">
        <property type="entry name" value="HalOD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18547">
        <property type="entry name" value="HalOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalX" evidence="3">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HalOD2" evidence="4">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="279" mass="30507" checksum="56D78FA16F7E6B13" modified="2013-07-24" version="1">MSSSRGDGGSTISEESTGTGQSVSVSPPTVLIADGPNRAKRYEQWIQDPFPVRRARSPDEARDEITKDIGVAIAGAGVSDETTQELLELVTVRSPFARAIVVQGDDQPPMLEGAGYDVCLFTPVEKGDLRQAVHQLARISTYERAVSAFFEYTTHAASIQVGKSEEELADHETYQKIQARIEQIKATLERIRSSMDEADRRVLMESIESDPAAGFSEHPSSSGGRHPDRCSECHLDWGTRHGDGLGKGYDQLGAFVWKCTRCGAVQQSASASHQWVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W884</accession>
    <name>R4W884_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446457.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01563">
        <property type="protein sequence ID" value="AGN01563"/>
        <property type="gene ID" value="L593_08090"/>
    </dbReference>
    <dbReference type="GeneID" id="16179997"/>
    <dbReference type="KEGG" id="sali:L593_08090"/>
    <dbReference type="eggNOG" id="arCOG10294">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174509_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="7549" checksum="FFE4D1EB5F88641B" modified="2013-07-24" version="1">MHSVVELAGSLLAAVAFTLAGLFVELQSVLSFAGGEMSTGTWFAVLGMLLLYAGVYLLGYERVVAQHVATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B9</accession>
    <name>R4W8B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445403.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02790"/>
    <dbReference type="EnsemblBacteria" id="AGN00509">
        <property type="protein sequence ID" value="AGN00509"/>
        <property type="gene ID" value="L593_02790"/>
    </dbReference>
    <dbReference type="GeneID" id="16182771"/>
    <dbReference type="KEGG" id="sali:L593_02790"/>
    <dbReference type="HOGENOM" id="CLU_2165371_0_0_2"/>
    <dbReference type="OrthoDB" id="142972at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="110" mass="11729" checksum="46F2A6466AF460C7" modified="2013-07-24" version="1">MDADLAGDLDAEQYDDLVADLAAQATTELPDRSRADAVWDTVGTVVPQLTDPVCNRVLDLADSEPRDALVEQVTSERGSDDAERLRAEALTALVGDVEARVVADTGDDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F2</accession>
    <name>R4W8F2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L593_08815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446602.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08815"/>
    <dbReference type="EnsemblBacteria" id="AGN01708">
        <property type="protein sequence ID" value="AGN01708"/>
        <property type="gene ID" value="L593_08815"/>
    </dbReference>
    <dbReference type="GeneID" id="16182476"/>
    <dbReference type="KEGG" id="sali:L593_08815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1806"/>
    <dbReference type="eggNOG" id="arCOG04276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_1_2"/>
    <dbReference type="OrthoDB" id="4783at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="11">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="175"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="969"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115119" checksum="B4DDFA38EC20BCA0" modified="2013-07-24" version="1">MSQPDHSADEVTLPIKRVEGDTLEDRLTGNAYHNILPARYLRKDADGELIESQEDLFDRVAKNVALAEAVFEARKRDVEITVTPDQLKPDHPRRDELAEEVFGKGVTADSDAETTLSEYNVNKFAYETLVPELPADIRDHVESTADAFQDAMESLSFMPNSPTLMNAGDELQQLSACFVDSPEDDIDDIHETAKEAAQVFQSGGGMGYAFWKLRPYGDPVGSTGGIASGPITFMRTYDQMCETIAQGGARRGAQMGVMRVSHPDVIQFIHAKNKDVSLANTLRLNDPDDFTHNSFADALEEARELIDDEGRVPEHLRNAVEGHLSNFNISVGVTNDFMDALQNDEEFTFTNPRTGEAHIATEQTKELYEMFGLGEYVEVGEELSIPAEELWTDIVEGAHENGEPGVIYLERVNEEHSFDVEAHPDHRILATNPCGEQPLEEYEACNLGHINLSTIAAEDAPDWRVWSERHADRFDSEAEAIEAFLEEAIDWEEFDRRIALGTRFLENVVTMSDFPVKKIEEKVRAMRKIGLGIMGLAQLYIQLGMAYGSGASNEVARQLMTHINHGSKEASHELAVQRGPFADWEDSKYADPTRYREWFEHQTGLEADDWEDGFPIRNHNTTTIAPTGTTSMVGNTTGGCEPIYNVAYYKNVSDDVQGDEMLVEFDDYFLRVLEENGIDVEAVKEEAQEQMAENEFAGVDGLTTVPDAIGELFVTTGDLSAKQHAEIQVACQAGVDSAISKTVNAPSDSTVDDAKEVFEYIYDHGGKGVTYYRDGTRSKQVLTTRAQNAEFADMDAEEVLAQIEEIFGGLEGFLEEPAVREAVESDVAEVLDVAPDLAEQYAEKRPRPDVLHGVTQRIDTGYGKLYVNINEDEDGRPFELFANIGNSGGFTASFTEALAKTISTALRSGVDPEEIADELQGIRSPKVAWDKGEQIQSIPDAIGTAMRRYLDDEINKAYPDQTNLTELEPGEEADGEAEAPAPETDGGGVAASGGAASADAGGSAQADAGGDQQALIDAGESPECPDCGALSLYYSEGCKTCESCGWSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K0</accession>
    <name>R4W8K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446762.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09615"/>
    <dbReference type="EnsemblBacteria" id="AGN01868">
        <property type="protein sequence ID" value="AGN01868"/>
        <property type="gene ID" value="L593_09615"/>
    </dbReference>
    <dbReference type="GeneID" id="16182767"/>
    <dbReference type="KEGG" id="sali:L593_09615"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1980"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_4_2"/>
    <dbReference type="OrthoDB" id="12800at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="493" mass="52304" checksum="5B8A3B4DC111F3E5" modified="2013-07-24" version="1">MTPDIGAYSTAELASAIRRGEVSPIAAVEHSLTQIDEGNDALNAIVTLLDDEAVERAEAAQHAVESGDSLGPLHGVPIVIKDLFDFKAGVRNTIGSAVFADFVPEETVPYVQRLEDAGAIVVGKGNTPEFGHKGTTDNQLFGPTSTPFDLDRNAGGSSGGPAAAVAAGLVPVAQGTDGGGSVRIPAAWCGVLGFKPSYGRVPQVSRPDAFMSHTPFIHAGPLARTVEDAAIVADVMCGPHPRDPFSVPDEEPDFQSAVRRGVEGLTIGYSPHFDDFPVDPRVRSVVDEAVDAFETAGATVERAGLDLGHSHTELTDLWIREIGGLYHSAVEGFKDDGLDLLADHREELSPEFAAMLEQTRDQTLIEAKRDDHVRSDVFDALQNAFERYDLLVTPTLAVPPVENAGEDEGETVGPTEVDGEPVDPLIGWCLTHPINMTGHPAASVPAGLTDDGLPVGMQVIGRRFADEDVFAAAGAIERVRPWREHYRSAPGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L8</accession>
    <name>R4W8L8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="2">N5-CAIR mutase</shortName>
            <ecNumber evidence="2">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purE</name>
        <name evidence="6" type="ORF">L593_03865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445618.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03865"/>
    <dbReference type="EnsemblBacteria" id="AGN00724">
        <property type="protein sequence ID" value="AGN00724"/>
        <property type="gene ID" value="L593_03865"/>
    </dbReference>
    <dbReference type="GeneID" id="16180697"/>
    <dbReference type="KEGG" id="sali:L593_03865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.785"/>
    <dbReference type="eggNOG" id="arCOG02464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_1_1_2"/>
    <dbReference type="OrthoDB" id="104083at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="213" mass="22964" checksum="0F29934D2FDD2D5B" modified="2013-07-24" version="1">MTDSVADLIDDLRAEAERDRPTEETPEIGIVMGSDSDLETMMTGGRRPGAYDALVDHLGFEEQTDYDEPPEARFTFETYVTSAHRTPDLMTAYAETAADRGLDVLIAGAGGKSADLPNMTASIAYPLPTIGVPVQEKSVDSVIGMPQGAPLTAVDAGKSFNAALSAVQILARQHEELEERLVAYHDDLRQGVGEDSRGLHELGTPAYHEQMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M6</accession>
    <name>R4W8M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00749">
        <property type="protein sequence ID" value="AGN00749"/>
        <property type="gene ID" value="L593_03990"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03990"/>
    <dbReference type="eggNOG" id="arCOG08918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195712_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6216" checksum="987ED6E010454708" modified="2013-07-24" version="1">MIDRAHRATLFALYQLSIALGIVMLPLAMAANRVGLRLPVHRVVEGLGNKYEAATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P3</accession>
    <name>R4W8P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor TFIIB cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446872.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10165"/>
    <dbReference type="EnsemblBacteria" id="AGN01978">
        <property type="protein sequence ID" value="AGN01978"/>
        <property type="gene ID" value="L593_10165"/>
    </dbReference>
    <dbReference type="GeneID" id="16181914"/>
    <dbReference type="KEGG" id="sali:L593_10165"/>
    <dbReference type="eggNOG" id="arCOG04613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155668_0_0_2"/>
    <dbReference type="OrthoDB" id="125922at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="10913" checksum="DA1DD8770E7C9BF5" modified="2013-07-24" version="1">MHSAKDRRDNAEWIEAIEEAATDLGLDDETGSVAVDLFLSTVPDADRSKPAAVAASVYAATLIAGEGRTQTAVADAVGVSRISVQQRWRERLESAGMEPPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q0</accession>
    <name>R4W8Q0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_10240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446887.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10240"/>
    <dbReference type="EnsemblBacteria" id="AGN01993">
        <property type="protein sequence ID" value="AGN01993"/>
        <property type="gene ID" value="L593_10240"/>
    </dbReference>
    <dbReference type="GeneID" id="16182154"/>
    <dbReference type="KEGG" id="sali:L593_10240"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="388" mass="41658" checksum="4C067753C2957216" modified="2013-07-24" version="1">MQLTEEQRTMRDVVREFAETELRPADREGDETETFPEGAWDDLTELDLTGIAVPEEFGGIDADMVTYAVLNEAVAYGSLSIATAMSVHGLACACIDTFGSDAQRERWLPEMATGRPVGAFALSEPGAGSNPAEMTTTARREGDEYVLDGEKQWITNATRAGVAIVFAKAVPEDAGAGASPDDTGETVTQFLVPTDLDGFAVGEPEDKLGLRASDTAPITLDSVRVPAENRLTEEGRGLAAAFEILTGGRVAIGAQSVGLAEAAFDDAVAYAQEREQFDGPIADIQTIRHKLAEMRTELESARLLTREAARKLEAGADDAAVAASMAKYSASESAMSITNEALQIHGGYGYVSEFDVERYYRDAKITEIYEGTTQIQKEIVARHVLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8R7</accession>
    <name>R4W8R7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_04575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04575"/>
    <dbReference type="EnsemblBacteria" id="AGN00864">
        <property type="protein sequence ID" value="AGN00864"/>
        <property type="gene ID" value="L593_04575"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.933"/>
    <dbReference type="eggNOG" id="arCOG01081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="207" mass="23470" checksum="7A96F3EEB99298BB" modified="2013-07-24" version="1">MGTTENDAGSAEAADVGGSEEGADAEEPLEHPNAGQDVIAVDEQDETEGTVNRLDAHTGEGIRHRAFTCLLFDEDGRILLAQRSPDKRLWDTHWDGTVASHPVEGQTQEEATEERLEEELGITPDQYTDLRVTDRFEYKRYFEDQGVEHEVCAVLQATLTDTDLDPDEGEVAGVLWAPYDRLHENPRWYRQLRLCPWFEIAMRRDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W0</accession>
    <name>R4W8W0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445873.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05150"/>
    <dbReference type="EnsemblBacteria" id="AGN00979">
        <property type="protein sequence ID" value="AGN00979"/>
        <property type="gene ID" value="L593_05150"/>
    </dbReference>
    <dbReference type="GeneID" id="16181241"/>
    <dbReference type="KEGG" id="sali:L593_05150"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1051"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_0_2"/>
    <dbReference type="OrthoDB" id="92721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="CHP00062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00162">
        <property type="entry name" value="TIGR00162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="253" mass="27224" checksum="1A35E843EEF1270E" modified="2013-07-24" version="1">MDEFEIERPAEVDLEDAVLVEGLPGVGHVGKLAAEHLRDELDAETVRRIHSEHFPPQVTVGDDGVASLAAAEFHAVSTEGRDLLLLTGDHQAQSNEGHYHLTDAILDVADDFDVSEVYALGGVPTGELIEEYDVLGAASGEEIVETLEEHGVEFREDEPAGGIVGVSGLLLGMGARRGLDAACLMGETSGYLVDPKSAQAVLEVLEAVLDVEVDDEDLEDRADEMEEVVGKIREMEQQQQAPAPTEDDLRYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y4</accession>
    <name>R4W8Y4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ORF">L593_11215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447082.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11215"/>
    <dbReference type="EnsemblBacteria" id="AGN02188">
        <property type="protein sequence ID" value="AGN02188"/>
        <property type="gene ID" value="L593_11215"/>
    </dbReference>
    <dbReference type="GeneID" id="16180758"/>
    <dbReference type="KEGG" id="sali:L593_11215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2313"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OrthoDB" id="121171at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="18479" checksum="F304E42DB6258931" modified="2013-07-24" version="1">MTSKKRRQRGSRTHGGGTHKNRRGAGHRGGRGRAGRDKHEFHNYEPLGKHGFSRPQSVQEEVLEINASKLDEDAALYAAEGLAEETDGGYELDAREIVEDGFEADAVKVLGGGQVRGELTVVADAFSASARGLIEEAGGEAVLSERAETAEDEDGDADEAAAESEDVSPESDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z9</accession>
    <name>R4W8Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11340"/>
    <dbReference type="EnsemblBacteria" id="AGN02213">
        <property type="protein sequence ID" value="AGN02213"/>
        <property type="gene ID" value="L593_11340"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11340"/>
    <dbReference type="HOGENOM" id="CLU_2857258_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6986" checksum="D056C42C8E81C2ED" modified="2013-07-24" version="1">MLRYTVVRDAGSRSLRPSECTRYAKEITGSDPGVDSVVGSSSCGIDALDAVGTYYDRSRRLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W988</accession>
    <name>R4W988_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446168.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06635"/>
    <dbReference type="EnsemblBacteria" id="AGN01274">
        <property type="protein sequence ID" value="AGN01274"/>
        <property type="gene ID" value="L593_06635"/>
    </dbReference>
    <dbReference type="GeneID" id="16181825"/>
    <dbReference type="KEGG" id="sali:L593_06635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1354"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453169_0_0_2"/>
    <dbReference type="OrthoDB" id="19292at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="613" mass="67540" checksum="F3AFFE0169E19BEA" modified="2013-07-24" version="1">MAADDSAPAPEGYVEATDLQTLQDDGAAVAAADGTPIALFYHDGEVHAVDNACPHMGFPLIEGSVDDGILTCHWHHARFELSCGDTFDPWADDVASYPTRIEDGRVYVRPEPATDRPPEERWRDRLDTGLEENLRLVIAKSVIGLDAAGVPDEEPLERGLEFGATYRESGWSSGLTILAAMGNVLPTLTGHDHRRALYTGLRHVASDCSGEPPNFSQPAFDADVEPDRLVRWFRDAVEVRDRDGVERCLRTAVEQSSTGPHSQAPEDAVESEEHGRETIERMLFGAATDHLYLDSGHSLDMINKAIEALDRTQWANAEPILASLVPRLTEATRMEERSQWRQPVDVAGMCFDAFDELEEAAAQGANLRAERRNAADESNGWRWTPDDQFRETLLSDDPQAIVDALLAGVRDGAAPSDLAAPVVDAAATRVAQFGTSNEFNDWNTVHHTFTYANAVREAALRTEADALYRGVFDTAISVYLDRFLNSPPATIPEPDGDGDPESLREDLLDAMDREGAVNEAGRAAVEWLAVADGPEAVWTTLGETLLREDAGFHTLQNYEAGWRQFHRAASGSERRRALVAVARYQAAHFPTRREAEQTFSIATRLHRGEKLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W993</accession>
    <name>R4W993_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447382.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12745"/>
    <dbReference type="EnsemblBacteria" id="AGN02488">
        <property type="protein sequence ID" value="AGN02488"/>
        <property type="gene ID" value="L593_12745"/>
    </dbReference>
    <dbReference type="GeneID" id="16180151"/>
    <dbReference type="KEGG" id="sali:L593_12745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2615"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="OrthoDB" id="84020at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="263" mass="29099" checksum="D779A91FED86E4BE" modified="2013-07-24" version="1">MYLGDEAWPDLGSYFEAHSLAIVPLGSTEQHGPHLPLATDHLIAEGFAREAAERTGLLCTPTINVGVSTHHRQFTGTASVDPQAFRDYVESFTRNLAYQGVDRVIYVNAHGGNVEHLREVGRKLRNEELVYAIEWMWDESIPDLVDDLFAVNGPHAGPKETALIQHLAGDLVHDDRIEEARDGGLTNLGRAHGRKFGARTFYDAAENSENGAFGDQTDASAAKGETLFEAATDQLVHLCEWLDEQDFEDLTPKPHVRERSDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E5</accession>
    <name>R4W9E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13295"/>
    <dbReference type="EnsemblBacteria" id="AGN02598">
        <property type="protein sequence ID" value="AGN02598"/>
        <property type="gene ID" value="L593_13295"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13295"/>
    <dbReference type="HOGENOM" id="CLU_2550431_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="82" mass="8364" checksum="D261CF14FCD57583" modified="2013-07-24" version="1">MWGRVLARLVQRRRFVQLGIGSLVVAAAGFVVSGMSRLVVARDTALLLGAPLLLAGFSLAVAAFALAVLASIGVVDVDDSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F8</accession>
    <name>R4W9F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_13445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447522.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13445"/>
    <dbReference type="MEROPS" id="M42.005"/>
    <dbReference type="EnsemblBacteria" id="AGN02628">
        <property type="protein sequence ID" value="AGN02628"/>
        <property type="gene ID" value="L593_13445"/>
    </dbReference>
    <dbReference type="GeneID" id="16180629"/>
    <dbReference type="KEGG" id="sali:L593_13445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2750"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_2"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="37320" checksum="07025A2BD0D33A37" modified="2013-07-24" version="1">MEDVRREFLDDLLTTPSPSGYEVDGQRRWIEYVEPHADEVRTDDYGNAVAVLEGEADAPSIAVAGHGDEIGYIVRKIDDEGFVHLGRIGGSDRTVSRGQHVTIHGEDGPVNGVIGQTAIHLRENDDDTYDDIAEQRVDVGAEDGEEARELVEVGDAITISSTVEELNGSLIAGRGLDNRVGTWVAAETLRRAAEADVDATVYAISTVQEEVGLKGAKMIGDDLAPDAVVAVDVYHATDYPDAPGDKSSEVALGDGPVVGRGSANHPAVVDAVRAAADDVDLDVQIAADGIYTGTDADAFFTQAGGTPSLNLGLPNRYMHTPVEVVDTEDLDAAADVLAATAERASESAPFSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L1</accession>
    <name>R4W9L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14070"/>
    <dbReference type="EnsemblBacteria" id="AGN02753">
        <property type="protein sequence ID" value="AGN02753"/>
        <property type="gene ID" value="L593_14070"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2879"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="37079" checksum="7FA173815F35839E" modified="2013-07-24" version="1">MPSRQTPDSDAAVATDGGVSERPESPGRTLRQQEWVRALPFWLPPFLLVSLFVYGAITWNFVISLTDWRGLGDPSYEGLDFEFYVTFFDRVVDGLLNGGTIESQAFRNTIVLLVVFTVASLILGLLLAILIDRGIRLENGFRTIYLLPMSLSFVVTAILWRWMYRNNGGVINSSLEAIGLDALTRVWLGDPATKLFAIIFALTWQFSGYCMVVYLAGLRAIPDEHYEAARVDGASTIKMYWRVILPQLRASTTSAAVVLMVFGLKAFDFIFVIFRGANPGPSADIMPIFMYRLAFGQRQWAYGSTVATVLFLMALGIIAPYLYVQYRRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N1</accession>
    <name>R4W9N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447707.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14370"/>
    <dbReference type="EnsemblBacteria" id="AGN02813">
        <property type="protein sequence ID" value="AGN02813"/>
        <property type="gene ID" value="L593_14370"/>
    </dbReference>
    <dbReference type="GeneID" id="16181215"/>
    <dbReference type="KEGG" id="sali:L593_14370"/>
    <dbReference type="HOGENOM" id="CLU_2165373_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="110" mass="12708" checksum="908EFB5DDA68DB50" modified="2013-07-24" version="1">MQGSLLCDDEAQELLKERDIDITSGQKHDLQDIRNDAQTLNYKLYELESLGIADTQVKLLASDAFENLRKGEREILQTEKKPFWRPLLAIGLKILLVFEKILRLLGLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q5</accession>
    <name>R4W9Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447787.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14795"/>
    <dbReference type="EnsemblBacteria" id="AGN02893">
        <property type="protein sequence ID" value="AGN02893"/>
        <property type="gene ID" value="L593_14795"/>
    </dbReference>
    <dbReference type="GeneID" id="16181485"/>
    <dbReference type="KEGG" id="sali:L593_14795"/>
    <dbReference type="eggNOG" id="arCOG00818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_9_3_2"/>
    <dbReference type="OrthoDB" id="130137at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9872" checksum="83394AB82D297BE1" modified="2013-07-24" version="1">MGRDTRIVGERGQITIPKDLREQFGIRGGDEVVVRAEEDKIVIAQRTVDDRLAEGYREWNDRDRTVARTTSADATDRDDPDDVPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R0</accession>
    <name>R4W9R0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crcB</name>
        <name evidence="7" type="ORF">L593_14895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447807.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14895"/>
    <dbReference type="EnsemblBacteria" id="AGN02913">
        <property type="protein sequence ID" value="AGN02913"/>
        <property type="gene ID" value="L593_14895"/>
    </dbReference>
    <dbReference type="GeneID" id="16181704"/>
    <dbReference type="KEGG" id="sali:L593_14895"/>
    <dbReference type="eggNOG" id="arCOG04701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_1_4_2"/>
    <dbReference type="OrthoDB" id="112898at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="12731" checksum="280DDD57F678A3E0" modified="2013-07-24" version="1">MTEPLHRFGPGPLVASGGFAGAIVRYGVDVLVGASLESTLLVNAIGSVALALVLAGWLDHGGSDRLRRFAATGFLSSFTTYSAFVVGTIQSDPPVAIGYVVATYAVGFTCAGLGLAIAERGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S5</accession>
    <name>R4W9S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446628.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08945"/>
    <dbReference type="EnsemblBacteria" id="AGN01734">
        <property type="protein sequence ID" value="AGN01734"/>
        <property type="gene ID" value="L593_08945"/>
    </dbReference>
    <dbReference type="GeneID" id="16182576"/>
    <dbReference type="KEGG" id="sali:L593_08945"/>
    <dbReference type="HOGENOM" id="CLU_1976628_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13270" checksum="073E36D90ABABAF4" modified="2013-07-24" version="1">MTDESDHSRSDRSRSDDDSVDESTGTADDAWSDGWESAADRAAEEDAPSEGAGANAGRTATGSEDASDEEEYEPSIAGVFGARPEDAPPRPEIVPETPSLENALFLLLGVLFGLFVIYRAATVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X6</accession>
    <name>R4W9X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446863.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10120"/>
    <dbReference type="EnsemblBacteria" id="AGN01969">
        <property type="protein sequence ID" value="AGN01969"/>
        <property type="gene ID" value="L593_10120"/>
    </dbReference>
    <dbReference type="GeneID" id="16181910"/>
    <dbReference type="KEGG" id="sali:L593_10120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2086"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OrthoDB" id="59861at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="241" mass="27074" checksum="528A2B7D281A1F48" modified="2013-07-24" version="1">MISLDEAVTARLESHGERFEVLVDPDAALEIKRGEFEGDLEDVIAAEDVFEDAASGDRPAESDLEDVFGTTEALEIIPQVIQDGEIQITAEQRREMQEQKHKQLVDQITRNAVNPQMDDAPHPPERIESALEETDFRIDPMEPVEPQVDEALDALRPVIPIRFDEVTVAVQVPADYAGSAQARIRQFGDLEREEWQPDGSWVGVLTFPAGMQDDFYDLVNENTSGEAETRIVRDEDEISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA01</accession>
    <name>R4WA01_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="7" type="ORF">L593_10745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446988.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10745"/>
    <dbReference type="EnsemblBacteria" id="AGN02094">
        <property type="protein sequence ID" value="AGN02094"/>
        <property type="gene ID" value="L593_10745"/>
    </dbReference>
    <dbReference type="GeneID" id="16181399"/>
    <dbReference type="KEGG" id="sali:L593_10745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2215"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_2"/>
    <dbReference type="OrthoDB" id="69863at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="40603" checksum="9C7BBFC82D410D5F" modified="2013-07-24" version="1">MQPRDLSSHAEYVPGEGIEEVARELGMDPADLTKLASNENPFGPPADAVEALRDHADRISAYPTSAHSDLTAAIAAHWDLDDEQVWLSPGADGAIDLLHRATIEPDQEILVPEPGFAYYPMSARYHHGEVQTYPVAKERDFQVTPDVVLDAYDGERVVYLTSPHNPTGATVPLDDVEAIADRTNEETLIVVDEAYGEFADVESARSLLDERDDVAILRTFSKAYGLAGLRLGYALVPDDWADAYARVNTPFAVSELACRAGLAAMDDEAHVERSVETVEWAREYMANEIDAPTWPSGGNFLLVEVGDAGAVAEALKREGVIVRDCTSFGLRECIRITCGTEDQTREAVETVNEVLAARGDGGAAGDAEAEAATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA35</accession>
    <name>R4WA35_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ORF">L593_11605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447158.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11605"/>
    <dbReference type="EnsemblBacteria" id="AGN02264">
        <property type="protein sequence ID" value="AGN02264"/>
        <property type="gene ID" value="L593_11605"/>
    </dbReference>
    <dbReference type="GeneID" id="16180315"/>
    <dbReference type="KEGG" id="sali:L593_11605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2392"/>
    <dbReference type="eggNOG" id="arCOG03068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_2"/>
    <dbReference type="OrthoDB" id="19571at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="2"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="79"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="520" mass="55820" checksum="8248323697661118" modified="2013-07-24" version="1">MQAALIILDGWGLGDHDRRDAVKAANTPVFDRVAEQGAYGTLNVSGRDVGLPEGQMGNSEVGHLNIGAGRVVKQPFTKINDAIAAGELDDNNALLGAIDGARDRGGRVHFMGLVSDGGVHSSQQHLHALIDLAAERGATAVTHAFTDGRDTDPDSGAGYVEELEAHVAEAGTGDVATLEGRYWAMDRDTNWERTKKAYDAIVAREAEYEAESGLDAVSQAYDRDETDEFIEPTLIEGQPALEDGDAVVFFNFRPDRARQLVRMLTNTEPDWEYDLDPPEIDLATLTEYDETFDFPVAFPPDEPEATLGSTLADNGRTQLRTAESEKYPHVTYFLNGGREVAYEGELRNIVESPDVPTYDRQPEMSAAGVTDQAIEIVDAEDPDVLVLNYANPDMVGHTGDFGAAIAAVETVDEQLGRLLGMLEDHGAHVLITADHGNADDMGTEDDPHTAHTTNPVPFVSVAPSPADPDADVGDPAAVDRTGGFRVRDGGRLADITPTILALLGIDQPPVMTGESLLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA46</accession>
    <name>R4WA46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxoguanine DNA glycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447213.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11880"/>
    <dbReference type="EnsemblBacteria" id="AGN02319">
        <property type="protein sequence ID" value="AGN02319"/>
        <property type="gene ID" value="L593_11880"/>
    </dbReference>
    <dbReference type="GeneID" id="16181978"/>
    <dbReference type="KEGG" id="sali:L593_11880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2445"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_0_2"/>
    <dbReference type="OrthoDB" id="83981at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="2">
        <location>
            <begin position="149"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="35109" checksum="011B5C4DEE3DF874" modified="2013-07-24" version="1">MERGSIDLATLPGGLDLYATLESGQSYGWIREDGRCYEGDGPPRWREPATASEDASTDARSDSPWYVRVVDGDVLRVRQRGGVTDGTLEWEGSADLEADLRRLLRLDDDLPAILESAPDDPLLASAIEYAPGMRLVRDPPFETLIAFICSTQMRVARIHGMVTALAQAYGESVAFDGRTYHAFPEPAALADATEAELRDLGLGYRAPYVQETAELVASGELEPTDALGESYEDARELLTGFVGVGDKVADCILLFSLGYLEAVPLDTWIQTAIAEYYPECDRGNYAETSRAIRERFGGEYAGYVQTYVFHWLRVGPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA90</accession>
    <name>R4WA90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00270 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13000"/>
    <dbReference type="EnsemblBacteria" id="AGN02539">
        <property type="protein sequence ID" value="AGN02539"/>
        <property type="gene ID" value="L593_13000"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2665"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="179" mass="18667" checksum="8E88F9C2D7781D6B" modified="2013-07-24" version="1">MCGASTSSPKTIKVEGAELEVCSDCTDFGTEVRDQDASSSTSTKYSTSSSGSSGSSGGGGSSSSGSGRSSGGGGSSQRRSDMFDDMDEIATDYDDRIRSAREDEGLSQADLANELNEKASLIRKLERGETLPSDEVQSKLERHFDISLSGSAGTDEDAEWEGGGDAGEYTLGDVVKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA93</accession>
    <name>R4WA93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13075"/>
    <dbReference type="EnsemblBacteria" id="AGN02554">
        <property type="protein sequence ID" value="AGN02554"/>
        <property type="gene ID" value="L593_13075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2680"/>
    <dbReference type="eggNOG" id="arCOG04755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="286" mass="31341" checksum="BCC1BA360986EED2" modified="2013-07-24" version="1">MFFRGVAIIVPVIVTVFLISVALSYIGRALGPFVDLLEYVGLIDTFRQVELVRFLIDIGIYEYVVDFLAELIALVILLGIVLAVGSVGHNRYGERVIEVLDMAIASIPGIGTVYKSFRRMGDVMLTTEDENFQDVKLVQCLDEDMYVIGFQTSAAPEAVEDATDHEDMMTLFVPMAPNHVTGGFLTCVPTDRVYDVDMTIEDGVKSILTSGVATGKGAAQRDQLTLDNVRNVAQVDRIQDAFAGQQTAAVSPDDPTAVREERADEEPPNEERGAVDDADEELDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA5</accession>
    <name>R4WAA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_13375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447508.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13375"/>
    <dbReference type="EnsemblBacteria" id="AGN02614">
        <property type="protein sequence ID" value="AGN02614"/>
        <property type="gene ID" value="L593_13375"/>
    </dbReference>
    <dbReference type="GeneID" id="16180576"/>
    <dbReference type="KEGG" id="sali:L593_13375"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_9_2_2"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="383"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="465" mass="48047" checksum="4CB831501F37F556" modified="2013-07-24" version="1">MTLFGTAGIRGDVREAVDPELALAVGRAAARHAVTTDDSGSSPSFALGIDGRETSEGLAAAAAAGLASGGAEVEQIGRVPTPTLAFASRGRRGVMITASHNPPTDNGIKLFHDGVEYDGEAESRVEELVAADPAPGNWDEWGSIRDGSVLDAYRGAVVDYLTERFPEAIQALAGQRVAVDCGNGVAGLATPQILGALGATPVALNANVDGSFPARESKPTPESLTGLRRLVAADEQIAIGIGHDGDGDRLAVVDPDGDVVHEDTVLAVIAERYVRDSAAGDPVVVTTPNASGRIDERVAAAGGRTERIALGLLHEGIARERAAGGDDTAVVFAAEPWKHVHPAFGGWIDAIVSAALIAALAAEAGGIERLTADVVERPYRKENVPCPDAAKTAAMRRVEAALPERFESTAVDTEYGIRVELAGGGWVLVRPSGTEPYLRIYAEADAVDEVVTTARGVVEGAVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAB0</accession>
    <name>R4WAB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glyA</name>
        <name evidence="12" type="ORF">L593_13500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447533.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13500"/>
    <dbReference type="EnsemblBacteria" id="AGN02639">
        <property type="protein sequence ID" value="AGN02639"/>
        <property type="gene ID" value="L593_13500"/>
    </dbReference>
    <dbReference type="GeneID" id="16180029"/>
    <dbReference type="KEGG" id="sali:L593_13500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2761"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OrthoDB" id="22518at2157"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="11">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="418" mass="44919" checksum="24B081AEB5AE7A49" modified="2013-07-24" version="1">MRHDSVREADPAVADALEGEIERQQTSLQLIAAENHVSEAVLDAQSSVLTNKYAEGYPGARYYGGCEFADEVEQLAIDRAKELYGADHVNVQPHSGTQANQAVYYAMLEPGDKILSLDLEHGGHLSHGHPANFAGQLYEVEQYEVDPETGYLDYEGLHEHAEEYEPDVIVAGYSAYPREVEWERIRAAADAADALMVADMAHITGLVAGGAHPSPVGIADFVTGSTHKTIRAGRGGMVMCDEEYADDLDKAVFPGGQGGPLMHNIAGKAVGFEEALQPEFEEYAEQTVANAKALGEHLQEHGFELVSGGTDNHLVLVDLRPSHPDTSGGDAEEALEDAGLVLNGNTVPGETRSPFDPSGIRIGTPAITTRGFGEDESRTVAHLIARVVDAVAEGTEDEVVPDVRETVENLCAEHPIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD4</accession>
    <name>R4WAD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <location>
            <begin position="10"/>
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        </location>
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        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="21028" checksum="87DB9B29565A0EAF" modified="2013-07-24" version="1">MEGVTARDVMSRAFAGVSEGDDVDDVRELLIEERVDDVLVLRGDEPVGHVSAHDVLEFLSRGAQGDSAPVESIMQPAPEAIDADSDLADVLARLSTSGVDRLPVTNGDAELVGVVTEADVIAAASNVVSEPRAPSVGGPEPVSEAEEDAIAGTGQSAVARTTGKEHEATSGQYSNQSVCESCGTLSADLQVVNGQAICPDCRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE8</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="EnsemblBacteria" id="AGN02829">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyclase_SnoaL-like"/>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="16263" checksum="4B22A6A492940156" modified="2013-07-24" version="1">MATTQSPTDKHKQLARRVPEDVATEHKLDVIDEITTEDVVDHTPMGDAEGRDELKAEIAEMIEAFPDFSATVEEIFAEDDLVSMRVTLRGTHEGELWGMEPTGNTFEVPNNVVTRIEDGLIAERWLVLDTMGMLRQLGLVDLPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG00844">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="22750" checksum="D9DD187BA8187ABA" modified="2013-07-24" version="1">MRIREAAAGDGDVIGSVHERSVRQLAADAYDDAVVEAWVTLPDDDSGDTDDQADDVDDEGEDTDETDGADDAADESDTHADDSVGVQPDDGRLFVAEVPADDGAGARMIAGFGDVRFEPPEYLDEPADGGIRAVYVDPDHAGEGVGSALLRRLEVEARDEGLDSLGFLASVNARGFYERHGYEAISERRFDFGDGVEGPAVEMRRELDANRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VS69</accession>
    <name>R4VS69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444959.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00550"/>
    <dbReference type="EnsemblBacteria" id="AGN00065">
        <property type="protein sequence ID" value="AGN00065"/>
        <property type="gene ID" value="L593_00550"/>
    </dbReference>
    <dbReference type="GeneID" id="16181667"/>
    <dbReference type="KEGG" id="sali:L593_00550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.112"/>
    <dbReference type="eggNOG" id="arCOG05227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097445_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="165" mass="17773" checksum="2EE06B2FCBF2E21E" modified="2013-07-24" version="1">MSSLVVLAFEDMDGAEGMRERMYDFQKRELITLEDAAVVVRKENGHAKVKQAHSLVGSGALGGAFWGMLIGLLFLAPWLGLIAGAAGGALGGKLGDVGIDDSFIKEVSETVEPGQSALFLLVRDAQLERIEQETEDMNFTIIDTNLSPEDETQLRETFAAEEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSD9</accession>
    <name>R4VSD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445024.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00875"/>
    <dbReference type="EnsemblBacteria" id="AGN00130">
        <property type="protein sequence ID" value="AGN00130"/>
        <property type="gene ID" value="L593_00875"/>
    </dbReference>
    <dbReference type="GeneID" id="16182017"/>
    <dbReference type="KEGG" id="sali:L593_00875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.180"/>
    <dbReference type="eggNOG" id="arCOG04686">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637142_0_0_2"/>
    <dbReference type="OrthoDB" id="21042at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="91"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="463" mass="52816" checksum="A48AEF44CB518611" modified="2013-07-24" version="1">MTDADAETDADDADGVPPESDGDARSEKKTKPDDQGPVRIDEELARHVENKREELLEKFEIPDGFPPEVMEEAEQRTDDVGSEIQSEADERRDLRDLTTWTVDPVDAQDFDDAISIRREGDDYRLWVHIADVTHYVHPDSAMWASAVERANTVYLPGYTVHMLPPVLAETVCSIVPNEDRLAHTVEMELDGETLSYETIDIYKSVVRSDSRLTYTECEHLLDEPETADEYLEDPDVDLGERVDLAWELADRMHEQRKEDGSLVLNPRRDRAHTIVEECMLKANKAVTHELMWDRGVEAMYRVHPQPSPDEWGEALQEIQELDGVSIPAETWDEPRKAVNATLESAPERQLSDIQWAVMKVMPAAKYMNDPFGGHHALNFEIYGHFTSPIRRLSDLINHWIVHTNDVPEDLVALCDRASDKERDAEQCEREYRQFLQEVGLDADAVNNRGIEVVDDPADADYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTD0</accession>
    <name>R4VTD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445364.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02595"/>
    <dbReference type="EnsemblBacteria" id="AGN00470">
        <property type="protein sequence ID" value="AGN00470"/>
        <property type="gene ID" value="L593_02595"/>
    </dbReference>
    <dbReference type="GeneID" id="16182652"/>
    <dbReference type="KEGG" id="sali:L593_02595"/>
    <dbReference type="eggNOG" id="arCOG08110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026218_0_0_2"/>
    <dbReference type="OrthoDB" id="68711at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="427" mass="46539" checksum="4CC26396AAECA60C" modified="2013-07-24" version="1">MRRQLTIAGAALGVAAVTILLLAALAPPAPAPSEPLNEEVRERRVSFDGYESGVWPYLSSERGFRRTSPVNVVVRGEPSTVLEILKSGDATDFEDLPPEEEAEGPGPPGSRTDGPLNGTAGENLAIDWESTEGATRYAYVDDGSADGGRWIDESAQLQDGTYYGHRHHIRLYESPREDEPWVAMQAHSEHFDWFTLRHEVHGSDSTQDRVESAFFGDPRVDELWRSYVANDDSSDSDGWASMVVLLVGFSLIGGLTIDVDRHMQRTLTPVDRRRLHAVRERLSMRLGLLVVTNVAIVLGVRFGGIALERHAAFLTMHQIAALLYPILTLGLPLASYSLATGIERRMDAALGASSGLAIGVVADYMYLRVEMIAIPTLFQRLAVILALGLIAAGAASRATREHRINGLVTTGVILWVALLAATVLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTL2</accession>
    <name>R4VTL2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">dcd</name>
        <name evidence="5" type="ORF">L593_03120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445469.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03120"/>
    <dbReference type="EnsemblBacteria" id="AGN00575">
        <property type="protein sequence ID" value="AGN00575"/>
        <property type="gene ID" value="L593_03120"/>
    </dbReference>
    <dbReference type="GeneID" id="16182827"/>
    <dbReference type="KEGG" id="sali:L593_03120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.631"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_2_1_2"/>
    <dbReference type="OrthoDB" id="91282at2157"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="23974" checksum="F3014EC2C60B6BEA" modified="2013-07-24" version="1">MILSDRDIRRRLNDGDLSIEPLDDPEMQIQPASVDMRLGREFLTFEQSNIPCIRPDRAADASEYTTRTTIPDSSQSGGQRTLQDVADDADEETDTIDEEFILHPGDFVLATTKERVAIPDDLIAHVEGRSSLGRLAIVVHATAGIVDPGYEGQITLELSNLGTAPVALKPDMRISQLTFTKLSSAAERPYGEERGSKYQGQTGPQASRIGSDREFGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTN2</accession>
    <name>R4VTN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445489.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03220"/>
    <dbReference type="EnsemblBacteria" id="AGN00595">
        <property type="protein sequence ID" value="AGN00595"/>
        <property type="gene ID" value="L593_03220"/>
    </dbReference>
    <dbReference type="GeneID" id="16180195"/>
    <dbReference type="KEGG" id="sali:L593_03220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.651"/>
    <dbReference type="eggNOG" id="arCOG02264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050976_1_1_2"/>
    <dbReference type="OrthoDB" id="75041at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="428" mass="44880" checksum="9343606E25510F85" modified="2013-07-24" version="1">MRLVQVTIPTGKRQAVTDALEDEGVDFVLSDETSGREYAAVAHFPLPANAVEPILERLREAGLDEDAYTIVVDANTVISRRFEELETEYAEDADEDRIAREELESAADGLMPTSRNYYVLTVVSAIVATAGLLLDSPATVVGSMVIAPLVGPALAASVGTVIDDHELRVRGVALQASGIAAAILSAGLFAALVQAANLVPPGLDVLAIDQIRERLAPDFLSLAIALGAGVAGALSLSTGVSAALVGVMIAVALIPPAAVVGIGVAWGEPALATGSAVLVLVNVLSINLSALAVLWYQGYRPEYWFREDDVRTKTLTRIGVLAAVILVLSVFLGGVTYAGYQGAVAEEQIREESASVVAEHDGLRVLDVTVEEDSNPLTGRPDGVVITVGKPASTEPPPIAATLERRISDRVGRNVDVEVRFVDVQTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTY0</accession>
    <name>R4VTY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445574.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03645"/>
    <dbReference type="EnsemblBacteria" id="AGN00680">
        <property type="protein sequence ID" value="AGN00680"/>
        <property type="gene ID" value="L593_03645"/>
    </dbReference>
    <dbReference type="GeneID" id="16179957"/>
    <dbReference type="KEGG" id="sali:L593_03645"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.740"/>
    <dbReference type="eggNOG" id="arCOG02341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022064_0_0_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="384" mass="41736" checksum="618C253854E81245" modified="2013-07-24" version="1">MTPVGAANARGVEAPHVLHVDDEHGLVDLAATFLEREGLAVTTATDAETGLDRLEDNSIDAVVSDYDMPGTDGLEFLAAVREDYPDLPFILFTGKGSEEIASEAISRGVTDYLQKETGTDQYAVLANRIEESVRRYRAESELAETRRRHETLLANLPGMAYRATTEPGWPMSFVSEGCRAVTGYEAAQLTSGTVDWETDVIIPEDRVPARRTVETAVEQGEPFEVTYRITRKDGEERIVWEQGRAIDDGESADVTVLEGFITDVTARERNERALRTVSATQRAVLQQVTDGVFVVDLEAGEVLETNAAAADLTGYPEGELVGSDPKALLSAAETALADLTSAGEADLELPIARADGSPRRFTVSCSTLTFDEHRRLVLVLSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUH2</accession>
    <name>R4VUH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445754.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00860">
        <property type="protein sequence ID" value="AGN00860"/>
        <property type="gene ID" value="L593_04545"/>
    </dbReference>
    <dbReference type="GeneID" id="16180989"/>
    <dbReference type="KEGG" id="sali:L593_04545"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.927"/>
    <dbReference type="eggNOG" id="arCOG09132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606386_0_0_2"/>
    <dbReference type="OrthoDB" id="85914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="451" mass="48378" checksum="4ED45240C4A782B2" modified="2013-07-24" version="1">MTRLDRRALLRTGAFAAAAATAGCIFARGGAGERSFTRWLPRSQSGLVAAHLDLEIDAETQESEPLLPLILPDAEEASGPGYTPQIRGLDGVDDPMLTVPLALGARMTGLASIGLYAAGLGYLVDPEESATPVTKLINANDVLVAPGDVDTARAAEELRSGSPDSPFSIPHERVDEYGGFERYEPTTQQQGVVAVDDAAVVVADDRAGIEAVIDTFRGERTAATEAHDRLGWLFDTAREGHIGVGWLGDPDLEPYFFGEPGDALPQDAIDPWTDLYASIEFDPNTTELRASLSAYGVDGASPAQNRVASRFGSAGIDRESTIESDRVSVSAAYGNDVLDVRMQPRDEQGGSGDEHPDPDDEVPPAVDAGVPEDAFRFEYTPAEDRVDVYVEAELDVDSITVRTVESEWENSTSDTDVIEYLTVYVDPEGDEVHVIATVDDESGVVARYEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUW4</accession>
    <name>R4VUW4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445919.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05380"/>
    <dbReference type="EnsemblBacteria" id="AGN01025">
        <property type="protein sequence ID" value="AGN01025"/>
        <property type="gene ID" value="L593_05380"/>
    </dbReference>
    <dbReference type="GeneID" id="16181979"/>
    <dbReference type="KEGG" id="sali:L593_05380"/>
    <dbReference type="eggNOG" id="arCOG05411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511564_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="entry name" value="PTHR31451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="6">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="197"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="532" mass="57951" checksum="9684C47B0828DA4A" modified="2013-07-24" version="1">MTGDRTGGRGASKRPLRRRAYLAAVAATALAGCSGSDGDSSTDGEGSAQEDSGDVADGSTGDTGSGDDGTPEPRIASIDLEPATVRQTRPATTSVDVRNDGDATADVDVQVAVDGEVLDSKSVSVAPGASETVSVEHAFDAVGDHEVAASASTAGEIRDRGSTTVAVERYPASFVETEGTDFVLEGSTYRFLGANSNHLPVAQWGESYVDRWLDYVADRGVSVVRTWAFTPGWTDASVHAGPGNLREEWFEHLDYVIAAAKRRDVRLILPLIQNWATAEQPPSPAAYADWSDTAETRNDFFTDEQANGYFRNYVEHVLTRENRITGLAYRDDPTIFMWEVGNEMEYHGDRRGESLAEWYDATAAHVTSIDDAHLVGSGMHGATGDTYQDWNVRNAYVESHRSEHVDACSFHDYPVYEWDGINERGHDAFAEYVREHVRKAHEQVGKPAYLGEFGVHVDTGTEYDLAKRNAYLETGFEAAGETGLNGVALWAPDLHDPTTGTTYTHENDPLAIFPDDESTWAVVEEYRASLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV52</accession>
    <name>R4VV52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanol dehydrogenase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446009.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05830"/>
    <dbReference type="EnsemblBacteria" id="AGN01115">
        <property type="protein sequence ID" value="AGN01115"/>
        <property type="gene ID" value="L593_05830"/>
    </dbReference>
    <dbReference type="GeneID" id="16181862"/>
    <dbReference type="KEGG" id="sali:L593_05830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1194"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_2_2"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="34552" checksum="57F0F519F73E2926" modified="2013-07-24" version="1">MDVSAASDRSSAVVDEVLEAVIADREFVETVLTGVLARGHVLLEDVPGTGKTLTANSLATALGLEFSRIQFTPDLLPADVTGTHVFNEADRSFEFTEGPIFANVVLADEINRAPPKTQAALLEAMEEEQVTVDGDTHQLPDPFFVIATQNPVEQEGTFELPEAQVDRFLVKTTLGYPEEAGELELLRRRAGRSDRAPTVGSVLDADAVRELREVPEGVHVEPDVLEYIAAVGRATRIRPQVQTGVSPRGTQRLFEAARAHAVIDGRDFVTPDDVRRVALPVLSHRLVLTPEAAVEGVDTDEIVEDVLDSVPVPTVEPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW49</accession>
    <name>R4VW49_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease HII</fullName>
            <shortName evidence="10">RNase HII</shortName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">rnhB</name>
        <name evidence="13" type="ORF">L593_07500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 10 11">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446339.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07500"/>
    <dbReference type="EnsemblBacteria" id="AGN01445">
        <property type="protein sequence ID" value="AGN01445"/>
        <property type="gene ID" value="L593_07500"/>
    </dbReference>
    <dbReference type="GeneID" id="16182215"/>
    <dbReference type="KEGG" id="sali:L593_07500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1535"/>
    <dbReference type="eggNOG" id="arCOG04121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="OrthoDB" id="105421at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="12">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN01445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="225" mass="23617" checksum="A39C5E6E8DECF625" modified="2013-07-24" version="1">MHVGIDEAGKGPVLGPMVCAAVGVADRSVLPDGVADSKRLSPDRREALDAELRDDDRVAVGVAAIDVERIDDPETDMNRLTVAGQAEAAVGLLGDAPDSTAECAVLADAGDTSETRFARRLADAVDERYSGDLDRSVDARHGADDDDPVVAAASIVAKVERDARVAEIAAEYGDVGSGYPSDPTTREFLEAFVREQGALPGCARTSWQTCDDVLADVEQASLGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX45</accession>
    <name>R4VX45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445730.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04425"/>
    <dbReference type="EnsemblBacteria" id="AGN00836">
        <property type="protein sequence ID" value="AGN00836"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="214" mass="22595" checksum="4968C7511E87CA2B" modified="2013-07-24" version="1">MVQLTGSAVAIGLAGCTSSGSSDGGDSSDDGEESHDDEHQDGEESHGGEDSHDDGGSHDDGHNHDVGAPEEPSASVEVSLRTEGSEQHFAPHVVWVEPGGTVTWHNESGQHNSVAYHPENDKPLRIPQDAEPWETELLSEEGATASRTFDTEGVYDYFCSPHEAVGMVGTVIVGHPDAHGQPALEEPQSSLPDGARHQLADLGEMTNEALGHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXF2</accession>
    <name>R4VXF2_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51430"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="36105" checksum="5125F05431B891B8" modified="2013-07-24" version="1">MEYTTLGSTGMEVSKICLGCMSFGSEEPWMLDEDESRKIIERAIDLGVNFFDTANAYSDGESEEILGDVLADYDRDEQVIATKVRFPVGDDGPNASGLSRKTIEQAVAASKERLGIDTIDLYQTHRVDPDTPPETTLRALDDLVERGDVRHVGTSSMFAHELAERLRASEREDLVSFETMQNHYHLAYREEERDMLPLCDRNDVGVIPWGPLGQGFLTRPVSELEETARGDPENFHNPTDEYERGGGREINARLEELAADKGVTMAQIALAWQFQNEYVDAPIVGTTSVEHLEDAVEALEIDLSDSDVEYLEEPYEPQPIVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI8</accession>
    <name>R4VXI8_9EURY</name>
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        <submittedName>
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        <name evidence="2" type="ORF">L593_05135</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1047"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
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    </dbReference>
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    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="133" mass="14582" checksum="7E0EB1B25679EDC7" modified="2013-07-24" version="1">MDPSISLVTLGVDDLEESIRFYRDGLGLPLQDREADSDVAFFTLEGTWLSLYPRELLAEDATVPDEGPGFSGVTIAHNVETKAEVDETLQEAVDAGGRLVKPAQEVFWGGYSGYFADPDGHVWEVAYPQLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXL2</accession>
    <name>R4VXL2_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Transcription factor of MBF1-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10250</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10250"/>
    <dbReference type="EnsemblBacteria" id="AGN01995">
        <property type="protein sequence ID" value="AGN01995"/>
        <property type="gene ID" value="L593_10250"/>
    </dbReference>
    <dbReference type="GeneID" id="16181738"/>
    <dbReference type="KEGG" id="sali:L593_10250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2112"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574931_0_0_2"/>
    <dbReference type="OrthoDB" id="112492at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="18585" checksum="A174CE6EC454E449" modified="2013-07-24" version="1">MAKYSTGGSSGSGDGDACELCGAETDALREANVAGAQLLVCRDCAPHDDAAKTESRTGGGQDAGGSDDDQEIDRTRRAVQNTAKANDVWDGDSSHWEEEGTDYDDDPLPYLVSGYGEALTEARQEAGLQREELGEEMGIDESTLLAIEQGRATQAGVPGSVVEALEERLDVELSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXR1</accession>
    <name>R4VXR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446944.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10525"/>
    <dbReference type="EnsemblBacteria" id="AGN02050">
        <property type="protein sequence ID" value="AGN02050"/>
        <property type="gene ID" value="L593_10525"/>
    </dbReference>
    <dbReference type="GeneID" id="16182448"/>
    <dbReference type="KEGG" id="sali:L593_10525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2170"/>
    <dbReference type="eggNOG" id="arCOG04425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_2"/>
    <dbReference type="OrthoDB" id="108917at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="144" mass="15737" checksum="24386306FF5A9132" modified="2013-07-24" version="1">MPPSDRPTVAFVCVQNAGRSQMAYAFAQRAVRERALEDEIDLLTGGTRPADHVHDEVVRAMEDVGVDVGDRTPREVTFEEISESDYVVTMGCSADDVCPAGWGGENRDWDLEDPDGKPPEVVAGIRDEIEARVDALFDELADGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXR9</accession>
    <name>R4VXR9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446954.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10575"/>
    <dbReference type="EnsemblBacteria" id="AGN02060">
        <property type="protein sequence ID" value="AGN02060"/>
        <property type="gene ID" value="L593_10575"/>
    </dbReference>
    <dbReference type="GeneID" id="16181618"/>
    <dbReference type="KEGG" id="sali:L593_10575"/>
    <dbReference type="eggNOG" id="arCOG05123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357951_0_0_2"/>
    <dbReference type="OrthoDB" id="60789at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="22527" checksum="B9C57B5420D0B51C" modified="2013-07-24" version="1">MAETRVFVSHATADLDVAQNLCSSIRNLPLTVALAGEEVQPGRVRRNLEGQLRNSDLAIALLTDEGAADYWVNQELGYAVAKGLPIIPIVEDDAYLRGYVEGTDGVQYDAENPEVTVFNLLSRVRSELEPIGTLSSPNWYVAFPCNNGQCRAEVQLEIDQLQKDLWQKYEHGKLLRAECPECGASYEFNPATLGFVRSVPPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYU6</accession>
    <name>R4VYU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12480"/>
    <dbReference type="EnsemblBacteria" id="AGN02435">
        <property type="protein sequence ID" value="AGN02435"/>
        <property type="gene ID" value="L593_12480"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2566"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012344_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41728" checksum="D36A8C1FFD78EAE0" modified="2013-07-24" version="1">MPGAVGLQTTVAGLDAPLAVAFAPDADRRYIAERDGRILLHGPDGLQDDLFLDLRDTVQTEGEQGLLGVALHPDFSENRRLFVRYSAPLRDGMPEDYSHAFVLAEFEATADGRRARTDSERTILEIPEPRPLHNGGDLAFGPNGYLHVSVGDSGHSQNGQTVTKNLLGSILRIDVDDRAEGRAYVVPDDNPLVGQQGLDEYYAWGFRNPWRMSFDGNDLYVADVGQSSYEEVNLVENGGNYGWNIREGTHCFKADECPDETPDTVRDGERLLDPIIEYPHEGGPVSGVSVIGGAVYRGSMIPALDGRYVFADFIPEGRLFVAECPNDGDELWSTVAVEVDNEELLTRALSFGRDEDGAVYVLGTGAEGGGLFRIVPAKRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ09</accession>
    <name>R4VZ09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal flagellin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07680"/>
    <dbReference type="EnsemblBacteria" id="AGN01481">
        <property type="protein sequence ID" value="AGN01481"/>
        <property type="gene ID" value="L593_07680"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1574"/>
    <dbReference type="eggNOG" id="arCOG02079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308522_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1032" mass="110694" checksum="93388DC813DEAE75" modified="2013-07-24" version="1">MEPTNADSSGDRLRGQSDVIAIVLLLGMIFISATAVILMGGFMVESVQDQSRHDLAVDSAVQTHQQIAEALASGEARRLSVTDAVDVQVRTTGSMRVEMRNAAGAACSGTVSNVNPVETDLGSIVYDTPEGEVIYEGGAVWERTDAGLSVRRSPSISYDGDTARIAVQSVSTNATSLDGEIARPDERLQRALARNTTRMLRECPSNGFTEVNISLTSPYHELWAQHFHRQVDTTPNVTVSTRGDTVFATIENATTAHASRGLRFDGFHAPRVVGPNGPAPLPNHFNVTASVTNDDFRPRNATVELVIDGNVWTSSEFEVPTTGNVTTSLPASPLHRQADLVNLLGLQPSQSHPYTVRLLDDDDDVVSTTTGRFFLEDGGGGNVTFFDDSHTLSNGERTLSVNATLINTFPSNATGETVEFQITDEDVDMPSPVTAPLDVPAYGGTKEISFDVNVSSLPAGTYDYQLRHRGVTLNRTFTISTLSGSGTVVGDLRVESIDPSAEYVTVGDPFNVSLQLYNTAQNATTADVSLDLPGDASLSQQQSVQIPGGDRRTVTLEIPANDVDDLPTRQSHDYNVTIEHGNDEQGFPGSFVLLYPGSHLLIEENSTTRIGDDRWINVTLANHGMQPNGDNVTFSLYDADTGDLLGSTVTDEISLGRANATVLPFRLNESKLGGSYEYEVVYGSNPRGVATGEFTVDGTNLGNGNVSITTPGNGSVTVLGTEVSGYDDGYCWQDWFGNWDCTPSEKQWSPITVSTVLEINGTENANQFVNHANDDQYTHDEHNLNTFDTQTDTFTYDWSLDEGETANLTVRSRIWSLTTGGYQHVHTRSDNDPSTPDIHDEHPPESAWDSPARVVDASQGSNVESVRVLGNGDAVPNVNAASDDQRSAAEVLNQGAADRVHPNGTLDLGPNEAIFLFEMTDDPANYGDMWQAAHNTNGDPDYNDVITLVSFNPDNPGDVQFHIGDHSLSIGPAPDDPQNVNDTGEQQVNVNGTTQGPGSGGAPSPPQPQNPDPGSPSEPDEVDVDVGGIVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ64</accession>
    <name>R4VZ64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447454.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13105"/>
    <dbReference type="EnsemblBacteria" id="AGN02560">
        <property type="protein sequence ID" value="AGN02560"/>
        <property type="gene ID" value="L593_13105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180396"/>
    <dbReference type="KEGG" id="sali:L593_13105"/>
    <dbReference type="eggNOG" id="arCOG06234">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103621_0_0_2"/>
    <dbReference type="OrthoDB" id="117123at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="21694" checksum="072BDCAC69CB5DE8" modified="2013-07-24" version="1">MSIVRKLKSLLGLDEGGSEPERDVTVTVEHDPENEAAVKGADVEESTSGGSHAVAVSGDEDEDEAAAEEETESVADEAETSIEEETGTSVDEEAETGAEEEADTEAAPEDETATAAEDEPDEVEIPDAEEPEAPVDEESDEEEAEATEAAGSSEPVDVLNGIGPAYAERLGDAGVETVGELAAADAAGLAEESDIAEGRIQGWIDQAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ79</accession>
    <name>R4VZ79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447469.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13180"/>
    <dbReference type="EnsemblBacteria" id="AGN02575">
        <property type="protein sequence ID" value="AGN02575"/>
        <property type="gene ID" value="L593_13180"/>
    </dbReference>
    <dbReference type="GeneID" id="16179834"/>
    <dbReference type="KEGG" id="sali:L593_13180"/>
    <dbReference type="eggNOG" id="arCOG03460">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_0_2"/>
    <dbReference type="OrthoDB" id="79462at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="31007" checksum="91FA29216268C90E" modified="2013-07-24" version="1">MSDDHSLLVVGAHPDDCSIKAGGIAAKYVEAGHDVTFLSVTDGSAGHQEMGRTELAYRRRRETKAVARTLGIDYDVFDLPDGELEPTLDNRRKLIRYIREVDPDIVLGPRPNDYHPDHRYTAQLLRDAAYSLIVPNVCPDTDALDSNPIFGYVADHFQKPAPFEPDVVLDVSDVVETKVDALHCHESQMYEWLPYTFGELDSVPDGEEARREWLGNDGLGHLVENTEMNVAARFRDELRERYGEDAGDAVEHAEAVEISEYGAPLTDEDREALFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZM9</accession>
    <name>R4VZM9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447589.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13780"/>
    <dbReference type="EnsemblBacteria" id="AGN02695">
        <property type="protein sequence ID" value="AGN02695"/>
        <property type="gene ID" value="L593_13780"/>
    </dbReference>
    <dbReference type="GeneID" id="16180825"/>
    <dbReference type="KEGG" id="sali:L593_13780"/>
    <dbReference type="HOGENOM" id="CLU_2115578_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="11564" checksum="4D7543D773EB77CF" modified="2013-07-24" version="1">MTRERDAVLAGTLLCITLLFGWLGAAAPRGAWFLGGVGATVLAEVLAYRRAAAVRAAADRRWVVAASVASAGAAIGAGAMLVPDRAISFATGALCAYLCLLGIATASGWRPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZT9</accession>
    <name>R4VZT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447664.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14155"/>
    <dbReference type="EnsemblBacteria" id="AGN02770">
        <property type="protein sequence ID" value="AGN02770"/>
        <property type="gene ID" value="L593_14155"/>
    </dbReference>
    <dbReference type="GeneID" id="16181106"/>
    <dbReference type="KEGG" id="sali:L593_14155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2896"/>
    <dbReference type="eggNOG" id="arCOG01849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_7_0_2"/>
    <dbReference type="OrthoDB" id="84330at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="18096" checksum="F96820FFF151B9D9" modified="2013-07-24" version="1">MDSRSYAFEGTRPAIDEDAHVSRQATLVGDVSIAAGASVWPCAVLRGDVGPVEIGESAHVGDGAVLHASSAADEAMIGHGAVLNDATVGEDTLVGFNATLNSDVTIGAGSVVASGSVVPDGWTIPEDSFVRGVPAQVTPIEATSLDADRIAERYASGAYTDLASRHEELFADEAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZY1</accession>
    <name>R4VZY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446675.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09180"/>
    <dbReference type="EnsemblBacteria" id="AGN01781">
        <property type="protein sequence ID" value="AGN01781"/>
        <property type="gene ID" value="L593_09180"/>
    </dbReference>
    <dbReference type="GeneID" id="16182865"/>
    <dbReference type="KEGG" id="sali:L593_09180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1883"/>
    <dbReference type="eggNOG" id="arCOG02918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529599_0_0_2"/>
    <dbReference type="OrthoDB" id="60263at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="264"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="514" mass="52964" checksum="39CC041637F7A1E3" modified="2013-07-24" version="1">MSDPPDDRPAMPELDRRSVVGALAAGIGLSALGGTVVTAQDDGNETNGNGTDGDGMDGATMVDPLFGFPAASADVEPPVEVDHEVALDTIEREQPGVPIPEFVFDPVGLAVDPGDTVQFSLASPHHTISSYHPELGYTQRVPDGVGPISSPVLWTDSYFLYTFEEPGVYDLFCFPHEFAGMVIRIVVGEASGPATEAPPEAEWGEAIPSPESPIPPQGLAATVLRESALDPETIADQGSVAWSDLPAESKTLPPEYFDPSDPGATTAALSAADQGVFTEASGCARVVPTPVGLFWELLVEDVEGVTQAHIHEGGADVAGPVVAPLVVFNDELDGSGDGELADALPEEPIVESGFVADPELAQAVGETPSNYYVNVHTTQHPGGEIRGQLRRTTPMAERRGGGAPEGDGPVDEEDADDNGGDDQDDGGADGPPDDGDGPPEGPPDDGAGNETAPDGNVSEPEGNASAPGENATEPGNETTVDGNDTIGNDTIGNETMGNDTVDNDMMDNATNDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W053</accession>
    <name>R4W053_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446755.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09580"/>
    <dbReference type="EnsemblBacteria" id="AGN01861">
        <property type="protein sequence ID" value="AGN01861"/>
        <property type="gene ID" value="L593_09580"/>
    </dbReference>
    <dbReference type="GeneID" id="16182755"/>
    <dbReference type="KEGG" id="sali:L593_09580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1972"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103451_1_0_2"/>
    <dbReference type="OrthoDB" id="94658at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="156" mass="17160" checksum="33F412B971BD1C55" modified="2013-07-24" version="1">MFRSGAFVADHIRPIDEEQVQPNGVDLTLDAVLEPNEVGRIGRDGKTVAERTEIEPEGEDRVFHLDPGGYVVRYTETVGIPEEHVGFILPRSSLMRNGTTLETAVWDAGYEGKGEGLLQVTHPIEIEQGARFGQIVLAAADHEGLYDGSYQGERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W057</accession>
    <name>R4W057_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ORF">L593_14805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447789.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14805"/>
    <dbReference type="EnsemblBacteria" id="AGN02895">
        <property type="protein sequence ID" value="AGN02895"/>
        <property type="gene ID" value="L593_14805"/>
    </dbReference>
    <dbReference type="GeneID" id="16181497"/>
    <dbReference type="KEGG" id="sali:L593_14805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3023"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_0_2"/>
    <dbReference type="OrthoDB" id="24257at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="511" mass="55290" checksum="DEC0364FE1D1D640" modified="2013-07-24" version="1">MEWTEKYRPSTLTEVRGNDAARDELREWAESWEDHREAAIVHGRPGVGKTSAAHALANDLGWDVMELNASDDRTRDVVERIAGEASKSATLTGGTRRLVVLDEADNFHGNADYGGSRAVTDVVKDANQPIVLVANEFYDMSRGLRNACQEIEFRDVSARSIVPVLRDICRKEGVEFEDAALEAVAERTSGDLRSAINDLQAIAEGRDRLTEADVSTGERDGSVGIFDFLDLVIKEQGAEDALKSSYDVEETPDDLIQWIEDNVPKDYEGAELADAYDHLSNADRWLGRVRATQNYTYWRYASDAMVAGVAASRREPKGGWTRYGPPSFRSKLGRSKGTRNTRDGIAQRIAEREGCSLGTARRRVVPYLAAMTHHCKPRDLTVSVAAAYDLDAGELSFLTGSGEDTNKVQSIVEDAASLKESAAVDASQGAFEGATRDDGTTDGSDEDGVSGQAESNTAAQSDGQSTLADSGTNDDGTDSAEEDSAGNSSEPDADANGADDQEDQSGLDEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W074</accession>
    <name>R4W074_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isochorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447809.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14905"/>
    <dbReference type="EnsemblBacteria" id="AGN02915">
        <property type="protein sequence ID" value="AGN02915"/>
        <property type="gene ID" value="L593_14905"/>
    </dbReference>
    <dbReference type="GeneID" id="16181569"/>
    <dbReference type="KEGG" id="sali:L593_14905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3044"/>
    <dbReference type="eggNOG" id="arCOG02015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_8_4_2"/>
    <dbReference type="OrthoDB" id="19721at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="8">
        <location>
            <begin position="180"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="443" mass="47371" checksum="38597E334225DFD1" modified="2013-07-24" version="1">MDGSGAVSVVAGDGALVSHTRTIPDVALRAVLEAFGPPTVCWRTPDEPSLVGCGSAATLTATGADRFAEIRSQADDLFGSFEESTPRAARPRLFGGFAFHGDHEPGHPWTGFPGAYFVLPEILVVRDGEETRLTVTLTDVDEGAASERADEVAEQLERLPDPGPPASPPGFEHRRRDPSREQWNEQVLAAIDRIEDGSLRKVVLAQSTELSLSGPLSPSDALTRLAEPYPDCTRFALSPTAEATLFGATPERLVSLSGRSVETWALAGSTGRGDTEEEDEWLARELQKSQKDQHEHALVVDAIRDQLDPVAASVTTGQRRIRTLSTVQHLETPIAAELADAEHVLSIVEALHPTPAVGGLPPEAALETIRSTETFDRGWYAAPVGWFDAAGDGTFEVAIRSAVANGSSASLFAGAGIVADSEPDREWDEVQLKYGPMLEALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0A4</accession>
    <name>R4W0A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5-didehydrogluconate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447839.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15055"/>
    <dbReference type="EnsemblBacteria" id="AGN02945">
        <property type="protein sequence ID" value="AGN02945"/>
        <property type="gene ID" value="L593_15055"/>
    </dbReference>
    <dbReference type="GeneID" id="16182426"/>
    <dbReference type="KEGG" id="sali:L593_15055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3075"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_2"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
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        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="281" mass="31382" checksum="B14AF46E69DE4891" modified="2013-07-24" version="1">MTTPTTTLRGGDELPMVGLGTWNIEGEDLRNSLRAGLDAGYTHVDTAEGYRNEATIGEVLAEESVDREDLFLTSKVLPKNLGYESVIQSCKESLEKLGTDYLDLYLIHWPNPAISVRETLSAMAHLKREGLVRNVGVSNFDTYQLSAALHVSPVDISVNQIEFHPWLQRPDLVDFCREHDVAVEAAAPLGRTELFADEVLQELADDYGRSVPQIALRWAVERGVTVLPKSTSPEHVRANLDLFEWSIDEADLERIDALDRGEAVYDDRVRGWEGDVYGISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0J9</accession>
    <name>R4W0J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10530"/>
    <dbReference type="EnsemblBacteria" id="AGN02051">
        <property type="protein sequence ID" value="AGN02051"/>
        <property type="gene ID" value="L593_10530"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2171"/>
    <dbReference type="eggNOG" id="arCOG04584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077325_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="37053" checksum="7251DB20A854138C" modified="2013-07-24" version="1">MTVLFPVADVLLQVPILDMSWEHFAVLVLAAAAGGAFGAAVGALPSFVFTGFVVLLGEGLAALGGEGSEFTELGGADLASGVTGTIGFGPVTGPHVAFAGGVAATAYAGYRYPEMEPADWDYHFGKNILYAFGTKPDILAVGAVVGVLGMLIARFSGALDAPYDGIAFAVFATAVLVRIPFGYPVVGDPVRGGWLDMGPFEREEERGDGSGRLAVEPWLPQQYKWSGVAAIGLVGGALGGWTWIMTGSIFMAYGISAASLLFLNLGVEKFPVTHHITLGGSTFAVVAAAELNSELGVMLLAILGGLIGSLLAEFTQRIFYAHSGTHVDPPAMSITIYTLAIGLLYLADVLDSPGYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W114</accession>
    <name>R4W114_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447130.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02236">
        <property type="protein sequence ID" value="AGN02236"/>
        <property type="gene ID" value="L593_11455"/>
    </dbReference>
    <dbReference type="GeneID" id="16182099"/>
    <dbReference type="KEGG" id="sali:L593_11455"/>
    <dbReference type="eggNOG" id="arCOG06445">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860780_0_0_2"/>
    <dbReference type="OrthoDB" id="114750at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="14470" checksum="C10284AEAC6673BE" modified="2013-07-24" version="1">MSELTDRCFDCGTEYVPFTVENGRCPDCGSPATPIVGSPTVLDVRPLASVDADEVPGDDAIEVVVRDDTDRLIVYGFAVPAAGQSVAVAITFEDATIRRGDEHWDAIEGPDVVAEAVADSVGCRPGPPPRAHSDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2F5</accession>
    <name>R4W2F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14650"/>
    <dbReference type="EnsemblBacteria" id="AGN02866">
        <property type="protein sequence ID" value="AGN02866"/>
        <property type="gene ID" value="L593_14650"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2991"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="6"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="418" mass="45174" checksum="F3317FCFF7C85897" modified="2013-07-24" version="1">MPEDLLRVRGLTTRFFTQEGQVNAVEDVSFDVREGEVLGIVGESGSGKSVTALSLVDLIDDPGRVTDGEIWYRNEALADAARDRGDAAVDGDFVDVRQLALRHRRALRGPDFASIFQDPASSLNPSLPVGEQIAEAVEVQRRASANPRSTRSRTQSYGLGKFLVGAAVPGRGYLSEESKARAIELLEMVGIPDPAERAEALPHEYSGGMLQRAMIAQALAGEPNVLIADEPTTALDVTIQAQILDLLRDLQEETGMTILLITHNLGVIARMCDRVGVMYAGEIVERGTLEDVFDDPIHPYTRGLLGSIPDLESAGGRLQPIEGNVPSLLDHEMEDRCYFADRCPKAMEECLEKPPEFDGPGTANHRAKCYLADHPYEPEQALPEGYFEDGDGATGSDGDGGDGTRASEVRADEVGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2I7</accession>
    <name>R4W2I7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444881.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00160"/>
    <dbReference type="EnsemblBacteria" id="AGM99986">
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        <property type="gene ID" value="L593_00160"/>
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    <dbReference type="GeneID" id="16181087"/>
    <dbReference type="KEGG" id="sali:L593_00160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.32"/>
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    <dbReference type="OrthoDB" id="107971at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07719">
        <property type="entry name" value="arylsulfatase_AtsA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtsA-like_MBL-fold"/>
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    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
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    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="27025" checksum="6617BA31B86BE17D" modified="2013-07-24" version="1">MRVTFLGTGSAMPTGDRFQTGIVVEDGGERLLVDCGSGVLHRLQSDGPGYEAIDTVLLTHHHLDHVADLMPLIKARWLAGEEALTVAGPEGTEDLLEGLFDVHEYMQDRIDLTVRELDAGSATVGGFDVEARWTEHSLPCLAYRFDDRFAFSGDSEAFEALAEFLDGTAVVAHDCSFPDDVDVSNHATPAELGATLASADVDVGRIYLTHRYPHTDGREEEMLASLTEQYDVDARMAQDGLSVTIDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W335</accession>
    <name>R4W335_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00287">
        <property type="protein sequence ID" value="AGN00287"/>
        <property type="gene ID" value="L593_01670"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG09089">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485948_0_0_2"/>
    <dbReference type="OrthoDB" id="131006at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="181" mass="18238" checksum="9C85A67F0BDE5821" modified="2013-07-24" version="1">MKRRTVLSTVAAASAAGVAGCLSRGDDGSDDSDGDSNSDATDGDSGSDVTNDSGNVTNGGSGGCSDPCETPAIGEQSIETTSTTCDGQDTSEASARVDDHDVVVQGTLSASTPCHDAVLTDASIENGQLRVTVDVTPRDGVCAQCIAEISYRATIGVTNVDAIDGVQVRHVGGQEHSCELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3D9</accession>
    <name>R4W3D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445366.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02605"/>
    <dbReference type="EnsemblBacteria" id="AGN00472">
        <property type="protein sequence ID" value="AGN00472"/>
        <property type="gene ID" value="L593_02605"/>
    </dbReference>
    <dbReference type="GeneID" id="16180278"/>
    <dbReference type="KEGG" id="sali:L593_02605"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.528"/>
    <dbReference type="eggNOG" id="arCOG02989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197986_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="55" mass="6106" checksum="13BADA131E826D0F" modified="2013-07-24" version="1">MADLIVKAAVKEALDDKNVASDFYDELDAEVEELLEEAAARAEANDRKTVQPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3E5</accession>
    <name>R4W3E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445376.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02655"/>
    <dbReference type="EnsemblBacteria" id="AGN00482">
        <property type="protein sequence ID" value="AGN00482"/>
        <property type="gene ID" value="L593_02655"/>
    </dbReference>
    <dbReference type="GeneID" id="16180294"/>
    <dbReference type="KEGG" id="sali:L593_02655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.538"/>
    <dbReference type="eggNOG" id="arCOG09681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_21_2_2"/>
    <dbReference type="OrthoDB" id="41839at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01068">
        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="229"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="503" mass="54612" checksum="6EB6C89110DFE28F" modified="2013-07-24" version="1">MSTDSGFKITDDDRKAVDGTRLSDDIGIDEQEIRWRKEFTRFDSSDVDALEGMSDTFDRIAEDLVDEFYEHLQANNDAIAILESSSKPVEALKRSQEQYLVDLGSGGYDQSYFDRRARIGKIHDMLDLGPKFYLGAYSIYYEGVLDAIGSDVIESVRDGSLDGVDDDGSADEDAVQAAVDEVTERSLSVLKLLLLDQQVAMDTYIHSYSQQVEEELDRQRRVGQEVEDSARELEQASTDVAESADEITDAAEDQVSRCTEVSEEVSALGATVEEIAATADQVEAEASEAKEYAEAGQRSADDAIEQMEVVDDAADDVTEDFESLSERLAEIDDVVDVIHQISEETHLLALNASIEAARAGGEAAGFAVVAEEVKQLAEDAQEQADEIEQLVETIQTHRERALESLDETNEALVGGIDAVQDVDEQLDSIVQSVGEAADGITEVAVATDEQAASTEEVATMVDELADGAHDVADEIEDVAAATEEQTATISEVRTTASELTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3H1</accession>
    <name>R4W3H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02880"/>
    <dbReference type="EnsemblBacteria" id="AGN00527">
        <property type="protein sequence ID" value="AGN00527"/>
        <property type="gene ID" value="L593_02880"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02880"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.582"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="59" mass="6372" checksum="5319DC4335F01F54" modified="2013-07-24" version="1">MSESRQKRAQKCVSCGINVAGTNAASFDCPDCGTRIHRCAKCRKQSNLYQCPSCGFTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W421</accession>
    <name>R4W421_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04555"/>
    <dbReference type="EnsemblBacteria" id="AGN00862">
        <property type="protein sequence ID" value="AGN00862"/>
        <property type="gene ID" value="L593_04555"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04555"/>
    <dbReference type="eggNOG" id="arCOG06373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171555_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="11902" checksum="1459B4297DE85284" modified="2013-07-24" version="1">MSATSDGPGESAEGDRDAADGPAESADDGSGEPTRTTTHRPGDEVTHPDADGRTWSWRGDVLLVGIFLSLFVVPIVIYLQPPALEWRVRLLILPMIPGLVLAAAAVWATTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4A9</accession>
    <name>R4W4A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445911.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05340"/>
    <dbReference type="EnsemblBacteria" id="AGN01017">
        <property type="protein sequence ID" value="AGN01017"/>
        <property type="gene ID" value="L593_05340"/>
    </dbReference>
    <dbReference type="GeneID" id="16181329"/>
    <dbReference type="KEGG" id="sali:L593_05340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1091"/>
    <dbReference type="eggNOG" id="arCOG00664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="27697" checksum="30A1DCFF2C374F3B" modified="2013-07-24" version="1">MQAVVIAAGEGTRLRPLTEDKPKGMVEVADKPILTHCFEKLVDLGASELLVVVGYRKQDIIEHYGDEFQGVPITYAHQREPLGIAHALLTVEEHVDDDFMMMLGDNIFRANLADVVRRQMEDRADAAFLVEEVPWEDASRYGVCDTNKYGEITEVVEKPEDPPSNLVMTGFYTFTPAIFHAAHLTQPSNRGEYEISEAIDLLLQSGRTIDAVELDGWRMDIGYPEDRDEAEERILEEEGDVAESAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P0</accession>
    <name>R4W4P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446126.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06425"/>
    <dbReference type="EnsemblBacteria" id="AGN01232">
        <property type="protein sequence ID" value="AGN01232"/>
        <property type="gene ID" value="L593_06425"/>
    </dbReference>
    <dbReference type="GeneID" id="16181734"/>
    <dbReference type="KEGG" id="sali:L593_06425"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_5_1_2"/>
    <dbReference type="OrthoDB" id="56873at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="357" mass="37843" checksum="EFDF368E621B723A" modified="2013-07-24" version="1">MDTDASRYHAFVGTYTDGDSDGIYTCSLDPTTGVLERVGVTDAGDDPSFVAVHPSGDYLYAVNEVDDGAVTAMEIDRESGDLSVLNRVVTGGGADPCYCEVDATGEHLLVAHYTGGSVAVVPIGEDGRVDDPTHLVEHEGSGPNEERQEAAHPHSIRAGPANRFVYAPDLGADRVFVYEFDVDAGRLEPAEQPAVELPGGAGPRHMAFHPEEPLVYLLNELDSTLTVLERDPDTGALEVLDAASTLPDGVDDNLTADVHVHDSGEWVYASNRGHDSVAVFAVGEDGRSLSRTQVVSTGGEWPRNVALTPGGDYLLAENAHTDEVVTFAIDSEDGTLEPTDDVEAIPSPTCLQFLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Q1</accession>
    <name>R4W4Q1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="10" type="ORF">L593_06575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446156.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06575"/>
    <dbReference type="EnsemblBacteria" id="AGN01262">
        <property type="protein sequence ID" value="AGN01262"/>
        <property type="gene ID" value="L593_06575"/>
    </dbReference>
    <dbReference type="GeneID" id="16181870"/>
    <dbReference type="KEGG" id="sali:L593_06575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1341"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
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        <location>
            <position position="141"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <position position="154"/>
        </location>
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            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
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        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
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            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="28138" checksum="8AC5D432E6A1855C" modified="2013-07-24" version="1">MIDLRFSEAELARRREHIGSFLQEQVAAAGAEGAVIGLSGGIDSATAASLAVEALGANAVRALVLPGTVSTDQNMSHAELVAEELGIAYDLVPIGGMVDSVLDGFPEISDDKVAIGNARARMRAVCTYLIANHDERLVIGTGNRSEAQVGYFTKYGDGAVDCHPIGNLYKVQVRQLARALGVPEAIVEKPPTAGLWADQTDEEELGLRYETLDPILALHVDGPLSADATARELDVERETVDRVRELHAQSAHKRATPPSPEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W561</accession>
    <name>R4W561_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_07960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
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        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
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            <end position="151"/>
        </location>
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            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="28438" checksum="59327AE7ECB7275B" modified="2013-07-24" version="1">MSGDRRASSGPATEDGGVEGEADSFDGDPTEAAEQRTDLPAYGETWTYEGLIGAIPGLSISPRIAVALQIAGFEIAVLVMAAVYDFWDAALVGTLAVLVAGGGSAITLRMGDKLRSLPVPAAYRRLAFGSRIEIVLSVLAYVALVTYLFAVDPVGAEMTLLTDSLGEDPPVPAVYLALLLAWDVIYRIGIAWWASVAALWRSWRYDFDPEVARAIARADLWPLAFAVLQLALVPIVWDRPLLLFALIGHVVAVTTVVALSVVLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W586</accession>
    <name>R4W586_9EURY</name>
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        <submittedName>
            <fullName evidence="3">PQQ repeat protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_08185</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AGN01582"/>
        <property type="gene ID" value="L593_08185"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1680"/>
    <dbReference type="eggNOG" id="arCOG02492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027480_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
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        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
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        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00564">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="357" mass="38469" checksum="62C5270C89A49677" modified="2013-07-24" version="1">MTSWPMQQYDAQNTAAVPAPSPAGAELDWQFETDSGIRSSPVVADGIVYVGDKDGTVYAVGEDSQTHWKESVSGDKIDSTPAIYDDLLIVPFQTHLQAYDRFDGTEQWQYPSEYGVGELTVADDLVIFGDTTSRVQAVDAKSGEGEWTMPSGVYGSSYSEPPAVLAGEVIIPRSQGAENDSHELSAIDIETGHRRPLVRTTDYDFQTGVSVSNDRVFVGANDGVHSFDSSGTEVGVFPTDRPIESGLAISDGTVLAMSTNQNSGTLYALDPSLGHQQWSVETNNSVNTGPVISGDCVLWGHYGPEIDSTLKAVEIANGESAWSKTLDEISEYHQWAVARQRLYAAGSKGFIVALQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5L7</accession>
    <name>R4W5L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bifunctional CAAX prenyl proteinase / zinc metalloproteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446701.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09310"/>
    <dbReference type="EnsemblBacteria" id="AGN01807">
        <property type="protein sequence ID" value="AGN01807"/>
        <property type="gene ID" value="L593_09310"/>
    </dbReference>
    <dbReference type="GeneID" id="16182719"/>
    <dbReference type="KEGG" id="sali:L593_09310"/>
    <dbReference type="eggNOG" id="arCOG01334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_2"/>
    <dbReference type="OrthoDB" id="46523at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="432" mass="46904" checksum="C1B7D62EE6822752" modified="2013-07-24" version="1">MLAAHVVLVGLLVGTTALFSALSILNVRYGARAIRENADWLAEELGVEDPEEILGYQRARTGASLLQTWVSLALLLGALYAGVFTAAVDALADTGLDPILQGVVFVGGLLVAQRVVVVPFSAYSTFAIEEIFGFNEQSPRLWLKDQLLGLAIGLVIVLPLAGVLFWLIETFATPIWVGAGWALVIGVGLLMQILYPRVIAPLFNDFEPLEDEAAREAIEDLFEQAGFAASGIYTMDASRRSTHLNAYFIGFGSTKRVVLFDTLLEELSTPELEGVLAHELAHWKFNHIWKRVGASALQMGVVFAVFGWLLGTDWVPELFSLPAEATYAHLIVALLFVYPILELSAPLLNQLSLAHEREADGYAVDQLGAAEPMVGALATLASENLANPFPHPWYAAFTQSHPPIPERMRLVRERVSEGSGDVSVDAEPAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W600</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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    <sequence length="529" mass="55860" checksum="1A8B2B1036394417" modified="2013-07-24" version="1">MSSGEATAESTSEPDAASDDAGRDAAVPEAEREALVTIAHGAVVTSGGVSAQRALVSATEFVLARGLGPVAYGVYAFAWRIAETLVRLVTFGSVPAIQRYVPAAEDDPEQRSRTVALAYLTTLGVGTLIAGSVWFLAPSIDAATVNDPAFPPAMRLFAVLTGLIGLVMIVSAIFRAVGSARGEVLFNKLLRPAARLLGALAALALGYSVVGIAGAMVAAMTVLVAIGIPISIRVTGIKPTLRIGRESAAAYYRYASPVALSSLGKIFQNRVDVFLVGALLTAVAAGIYNVILVLVAVAWIPLLAFNQLLPPVASDLYAKDDFETLNAVYGSATRLIVTTVLPILAVQLVFGRELLRIFGSTYTRGYLPLGIYLAGVFVGSAVGATGWLLMMTDHQYARMALDWLLAVLNVVLTYAFVVTFGLEGAALGTSIAIAVQNFLQVLLLKRFEGLWPWDASYLTPLTAGGVMIGVMWGLRRASEGPLLIGVAVLVGLASYLGTLRLLGVDDRDRLVVRELTRRYRAGLTGRSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W608</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN00098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="11476" checksum="B0458310F11CFAF1" modified="2013-07-24" version="1">MIQGVRPVLLLLLDGDLDAFVSDVFVAAAALFVGMAILLLYRVVRGETMQDRVLAVNVIGTSTVVVLALLSVGLDEESLLDIALIYALLNFLTAVAISKFTVDRGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W619</accession>
    <name>R4W619_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446956.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10585"/>
    <dbReference type="EnsemblBacteria" id="AGN02062">
        <property type="protein sequence ID" value="AGN02062"/>
        <property type="gene ID" value="L593_10585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180748"/>
    <dbReference type="KEGG" id="sali:L593_10585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2182"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_2"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="372"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="475" mass="49898" checksum="61DEDD72073AC192" modified="2013-07-24" version="1">MPDPFVAIGGDAAGLSAASKCKREDPDRDVIVFERGNWVSYAHCGTPYFVKGEVEHLTDLLSLSPDEAEERGIDLRRRHEVTAIDTGEQVVSVEGPDGRFDQPYGDLLIGTGAHAITGPIPGTDLEGVFSLHGLPDAAAIRAMLADPDSFTAADLGGDPYLDEERVARFGDMAPPETVAIVGGGYVGVEMAEAFDAHDVDVRVFQRDVDLIPAFGDAVADEVADALRENGVEVHLDTVVEALESEDGRVSGLTCRDGTTLDLDAVLVGIGIAPNVELVENTPIELGDSGAIRIDDYGRTSVENVYAAGDCAEMEHVVTGESDWVPLGLTANRAGRAIGATVAGDPTDVGGIAGTAMLKAFEMECGRSGIVDHERAREAGFDPISKTITAGSRSGYYPGAKETVVTLTADRETGRLIGGTIAGEDRAAVRIDTVATALEADLTVDEVERLDLGYAPPFSPVWDPVLVGAKVLAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W643</accession>
    <name>R4W643_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_10785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446996.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10785"/>
    <dbReference type="EnsemblBacteria" id="AGN02102">
        <property type="protein sequence ID" value="AGN02102"/>
        <property type="gene ID" value="L593_10785"/>
    </dbReference>
    <dbReference type="GeneID" id="16180792"/>
    <dbReference type="KEGG" id="sali:L593_10785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2224"/>
    <dbReference type="eggNOG" id="arCOG04758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_2"/>
    <dbReference type="OrthoDB" id="4065at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="116"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="204"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="603" mass="68215" checksum="AEAF1594D6D938D5" modified="2013-07-24" version="1">MATVPERSELDDADTWNLESIYASDEDWEAAFEDARDAVAELDEYDETDVTDATALLDLLELRDDTMRTVSQVVTYARLRSDEDTRDQEYQAMQGRAQTLSAEARSAASFLEPAIQQWNRDDLEDLIADEPGLEPYEFHLEDVLRMKPHTRSPEVEELLADLSEVTGAPGDIYQLLANADMEFPTVEDPDGEAVEISQANLTNLLKRPDREFRQTVHESFYEEWGTVRNTVGASYENSVTADVRLAEARNYDTAREAALDGSNVPVSVYDALVETVEDNLDVLHRHAELKREALGVDDLQMWDIYAPMTGDDEPEVTWEEATDHVLAAIEPLGEAYQDRVAAGLEGGWVDVYENKGKRSGAYSAGTYDTQPFVLMNYQDDVSSMFTLAHELGHSMHSELTNDAQPYVYSDYEIFVAEVASTVNETLLTRHLLDTVEDEAFRARVLEEYLERFRSTLFRQTMFAHFEHETHRLVEEGESLTPDRLDELYGDLKADYYEPTVIDDHITREWMRIPHFYWAFYVYQYATGISSAVAIAREIAADFDAETSTPGDATEDYLEFLSRGGRGSPPELLEIVGVDVESGKAVEAAIAEYDERLDDVAETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W678</accession>
    <name>R4W678_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl4lp</name>
        <name evidence="4" type="synonym">rpl4</name>
        <name evidence="6" type="ORF">L593_11110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447061.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11110"/>
    <dbReference type="EnsemblBacteria" id="AGN02167">
        <property type="protein sequence ID" value="AGN02167"/>
        <property type="gene ID" value="L593_11110"/>
    </dbReference>
    <dbReference type="GeneID" id="16180554"/>
    <dbReference type="KEGG" id="sali:L593_11110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2292"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OrthoDB" id="65833at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_L4/L1e_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="249" mass="26631" checksum="0990AA23FA89DB52" modified="2013-07-24" version="1">MTTVHDLDGEAAGEVDLPSVFDADYRPDLIKRAVLAAQANRTQDYGADDYAGLRTPAESQGSGRGMAHVPQQNGVARRVPQTVGGRSAHPPKAEKDRGLDVNDKERQAAIRSAIAATADAERVRERGHEFDDELETPIVVDDEFEDLVKTQEVVSFLEATGLDADVERADEGRSIRAGQGTTRGRRTQEPKSILFVTSSEAGPSKAARNLAGADVATAAEVNAEDLAPGTHAGRLTVYTEAALEEVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W688</accession>
    <name>R4W688_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">L593_01250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445097.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01250"/>
    <dbReference type="EnsemblBacteria" id="AGN00203">
        <property type="protein sequence ID" value="AGN00203"/>
        <property type="gene ID" value="L593_01250"/>
    </dbReference>
    <dbReference type="GeneID" id="16182618"/>
    <dbReference type="KEGG" id="sali:L593_01250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.254"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_0_2"/>
    <dbReference type="OrthoDB" id="35979at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="320" mass="35638" checksum="571B4A5CC2724580" modified="2013-07-24" version="1">MRERTRASERAEEETTEKSAEDLSCPECGGLLVNDEEHGETVCDDCGLVVETDEIDRGPEWRAFDSKEKNQKSRVGAPTTNTMHDKGLSTNIDWRDKDAYGNSLGARQREKMQRLRKWNERFRTRDSKERNLKQALGEIDRMASALGLPDNVRETASVIYRRALEEDLLPGRSIEGVSTSCVYAAARQAGVPRSLDEISEVSRVEKNEVARTYRYVVRELGLEVRPADPESYVPRFASGLELSDEAEHRARSLLQNAKEKGVHSGKSPVGLAAAAVYAAALLTNEKTTQAAVSEVADISEVTIRNRYHELLEAEESLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6A3</accession>
    <name>R4W6A3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01450"/>
    <dbReference type="EnsemblBacteria" id="AGN00243">
        <property type="protein sequence ID" value="AGN00243"/>
        <property type="gene ID" value="L593_01450"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01450"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.295"/>
    <dbReference type="eggNOG" id="arCOG04622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104197_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="240" mass="25668" checksum="A950BBC797EB8401" modified="2013-07-24" version="1">MRGASGDDPDPADDPPEIDGVEETDGSTSPDADTAAPDGAEDEPVTPTERAADDVAGDTSGATDDTPEAPDDAPDAGEIDPAELTVPERSLHPRIRTIWIVRALGWSLFLGAIAVGATWQWLEVTLLAPAGLAAVILVLSVTHAIFRYRAWQYEFREDAIYLERGVLTRVRTVVPFVRIQHVDTARGPVDRVAGLSTLVVYTAGSRGADVTIPGIEADRADEHQRRLKQLAIAAEDDTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C3</accession>
    <name>R4W6C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445187.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00293">
        <property type="protein sequence ID" value="AGN00293"/>
        <property type="gene ID" value="L593_01700"/>
    </dbReference>
    <dbReference type="GeneID" id="16180590"/>
    <dbReference type="KEGG" id="sali:L593_01700"/>
    <dbReference type="HOGENOM" id="CLU_2713012_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="72" mass="7898" checksum="D3E0D4EA92BD066C" modified="2013-07-24" version="1">MPEGSDAYPGEEEIEWGSDPGPATDPDRQRVVTIASDDVVTVAERDELERRGATTAWISMDAEHVVDVADRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C9</accession>
    <name>R4W6C9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02227">
        <property type="protein sequence ID" value="AGN02227"/>
        <property type="gene ID" value="L593_11410"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11410"/>
    <dbReference type="eggNOG" id="arCOG08980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159738_4_3_2"/>
    <dbReference type="OrthoDB" id="128717at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="101" mass="10785" checksum="CBD6249DCF0DFD40" modified="2013-07-24" version="1">MSDRTPPGDRGESNDRGASGSPQTFQMSNDVEPSVRVVEAVAEATGCDPAALPTLYDAVDVDALNQLLRNVDADETLSIRIEYAERIVEIEAGGPIRVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K3</accession>
    <name>R4W6K3_9EURY</name>
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        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_12170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447271.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12170"/>
    <dbReference type="EnsemblBacteria" id="AGN02377">
        <property type="protein sequence ID" value="AGN02377"/>
        <property type="gene ID" value="L593_12170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182749"/>
    <dbReference type="KEGG" id="sali:L593_12170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2504"/>
    <dbReference type="eggNOG" id="arCOG04147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_2"/>
    <dbReference type="OrthoDB" id="74803at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="94"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22820" checksum="797CF30512FA4B71" modified="2013-07-24" version="1">MPERSNPELPPLPYDYDALEPHISEQVVTWHHDTHHQGYVNGLDSAEETLTENRSEGDFGSSAAAIRNVTHNGCGHYLHTLFWENMDPNGGGEPDGDLRERIEEDFGSYEAWKGEFEAAASAAGGWALLVYDPVAKQLRNLVVDKHDQGALWGSHPVLALDVWEHSYYHDYGPARGDFVDNFFEVVDWDNVASQYDDAVSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6M1</accession>
    <name>R4W6M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diphosphomevalonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447301.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12340"/>
    <dbReference type="EnsemblBacteria" id="AGN02407">
        <property type="protein sequence ID" value="AGN02407"/>
        <property type="gene ID" value="L593_12340"/>
    </dbReference>
    <dbReference type="GeneID" id="16179864"/>
    <dbReference type="KEGG" id="sali:L593_12340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2538"/>
    <dbReference type="eggNOG" id="arCOG02937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_2"/>
    <dbReference type="OrthoDB" id="50204at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MDD_C" evidence="6">
        <location>
            <begin position="198"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="328" mass="36041" checksum="692924677DA73720" modified="2013-07-24" version="1">MKATAIAHPIQGIVKYHGMRDAQQRLPYHDSISVCTAPSHSKTTVEFSMDNEDNTYLIDGEEVEGSARDRLDRIVEEVRERSDAPHAVYGVRMESENSFPTNVGLGSSSSGFAAIATALAEAAELDATLGELSAIARRGSASAARSVTGGYSHLRAGLNDQDCRSHRIDSEIAEDHKIVVGLVPSYKDTDDAHEEAVESHMFQARMAHIHEQIAECRDALRKDDFDRVFELAEHDSLSLAATTMTGPEGWVYWSPKTLQIFAAVRELREEDDIPVYFSTDTGASVYVNTTEEHVDEVEEAVADCGVQTAVWEVGGPARILKEEEQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N8</accession>
    <name>R4W6N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445387.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02710"/>
    <dbReference type="EnsemblBacteria" id="AGN00493">
        <property type="protein sequence ID" value="AGN00493"/>
        <property type="gene ID" value="L593_02710"/>
    </dbReference>
    <dbReference type="GeneID" id="16180311"/>
    <dbReference type="KEGG" id="sali:L593_02710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.549"/>
    <dbReference type="eggNOG" id="arCOG02979">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942000_0_0_2"/>
    <dbReference type="OrthoDB" id="63783at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="342" mass="35788" checksum="F02F8CAC2294529B" modified="2013-07-24" version="1">MLTVPEGVLERFRAFSLYNSPYRAHDDGSAIDLYPSAETGSNAPAAPSPVAGEVVSVERVRAPPKPYAPEHDVLLAVDTQQADGSAQYSTENDDAPIARILHVDPTEEDGVEVGDRVSVGDSLGQPIRAGFFAPWVGHHLHLGFRERDADLRRAAGSRPVSPATTVEAVPWDGRGTVVETADTYAVLDRPLHPDPGERFAAIAGSIGSSIDEVLDSATASGHDAATASGHDAATDAGLGSTDSAARAVALDGGLPHYDHGGLLGRQIDHGEEPVSLLGARIGTVSGRTAAWDDPTVLVEREGFDPTPIQGLSLAASRDDLGTKLICPDLSLAVGETVRVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P5</accession>
    <name>R4W6P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445397.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02760"/>
    <dbReference type="EnsemblBacteria" id="AGN00503">
        <property type="protein sequence ID" value="AGN00503"/>
        <property type="gene ID" value="L593_02760"/>
    </dbReference>
    <dbReference type="GeneID" id="16180258"/>
    <dbReference type="KEGG" id="sali:L593_02760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.559"/>
    <dbReference type="eggNOG" id="arCOG00047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057819_1_0_2"/>
    <dbReference type="OrthoDB" id="47556at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="37443" checksum="CFCE901F04841FBE" modified="2013-07-24" version="1">MYWLEFGGEDDPFAALEATAAASDVRMLAPGIGTATALAPDRMAGLALTTAAGEVVGHTDASVESARALLETAGIEREGTVAVRARDVRSSADVDTQRAERELGGVLTDRGFSVDLDDPDHTLRALFARGELARDGAAAEGSPLGVEASGLVEVAADADDADVCLLGWVDVERAAAFGDRAPTDRPFFQPGSMDPALARALGNLAGARPGATIVDPMCGTGGLLLEGTLLGARMVGVDAQQKMVRGSRENLGELAPRDADWEVARGDARRLPLAADAADGLVVDVPYERQSAVAADDLDDLVEGALAAAHDVAPRAVVVADREWVDAATSVGWTVECVHRRRVHRSLVRSVHLLERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U9</accession>
    <name>R4W6U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445477.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03160"/>
    <dbReference type="EnsemblBacteria" id="AGN00583">
        <property type="protein sequence ID" value="AGN00583"/>
        <property type="gene ID" value="L593_03160"/>
    </dbReference>
    <dbReference type="GeneID" id="16180448"/>
    <dbReference type="KEGG" id="sali:L593_03160"/>
    <dbReference type="eggNOG" id="arCOG01137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_3_2"/>
    <dbReference type="OrthoDB" id="128167at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="14521" checksum="B88E0BD8F904F34C" modified="2013-07-24" version="1">MAITTEIDVRYRDLDILAHVNNAVIATYVEEARLEYLDRVFDVGFEDYTFVIAHIEIDFERPIETDGSVTVTAEVPELGTSSVPMRYEIVADGERSATAETTLVFLDQAGESTVQIPDDVRARIEAHEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W4</accession>
    <name>R4W6W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447451.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13090"/>
    <dbReference type="EnsemblBacteria" id="AGN02557">
        <property type="protein sequence ID" value="AGN02557"/>
        <property type="gene ID" value="L593_13090"/>
    </dbReference>
    <dbReference type="GeneID" id="16180392"/>
    <dbReference type="KEGG" id="sali:L593_13090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2683"/>
    <dbReference type="eggNOG" id="arCOG02297">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_0_2"/>
    <dbReference type="OrthoDB" id="35875at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="31460" checksum="D1E0E48565E119C0" modified="2013-07-24" version="1">MSPQYNVDGEIVPAEEATVSVEDRGFQYGDGAFETLRAYGGDVFEWEAHADRLDRTCEALSLDHGLERAELRERIDETLAANEFDDAYVKCSITRGSQPGKLTPQPEVDPTVVVYAKELPRGGVDGDDVWDEPATLQTVKTRRMPDSAIPATAKTHNYLNGILARAELIETADEALLRDMDGAVVEGAASNVFFVHDDAVHTPSATRDLLPGITRRLVIDLAEDAGVPVRTGTYEPSDVREANEAFVTNTTWEVRPVDQVDGISVGGGAVTELLSRLFDELVEERHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Z2</accession>
    <name>R4W6Z2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13315"/>
    <dbReference type="EnsemblBacteria" id="AGN02602">
        <property type="protein sequence ID" value="AGN02602"/>
        <property type="gene ID" value="L593_13315"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2724"/>
    <dbReference type="eggNOG" id="arCOG03911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159099_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="130" mass="13773" checksum="FF1C656B21D49FCE" modified="2013-07-24" version="1">MSDHNGRSRLTVARLVGIALIGVLVVTAMSAPAAAHSGDDGDHHHDGLMGTHDGMGGWMDGGTGFLWMLLGTLVLVGIPVAFLYLLANGGSGRSDSTDGDALAVLRRRYAQGEIDEEEFEARRSRLRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W710</accession>
    <name>R4W710_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445572.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03635"/>
    <dbReference type="EnsemblBacteria" id="AGN00678">
        <property type="protein sequence ID" value="AGN00678"/>
        <property type="gene ID" value="L593_03635"/>
    </dbReference>
    <dbReference type="GeneID" id="16180661"/>
    <dbReference type="KEGG" id="sali:L593_03635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.738"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="388"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="595" mass="64722" checksum="EE99DD2ACE81114A" modified="2013-07-24" version="1">MQTVRALLIGVPDRTRADLLDAGIDVESVGSIDEATDRLHELRDGAPIHCVVGWIDDDRDVDLDVPATDAVPRPPRVLAGERPLAAIAADVVGAGVDEYVQFDPDADASAVVEVVERTAAEYEASLDRARVPIDAPDPGFLLRKGRIAVAADDLESCFVADELVGVEITSLVADADRDGLGDVLRSVGAKATSLRVTPLGDRHRTTELRLRRSPIDGAIVGTARDVTDDEHERAAMAEAAAQLDSLLQNIPMSIYFKDELGRHERVSDNITQTDPDEYIRNDEGKVHPHSDDVIGKTDFDLYAPSFAEQTYEDDMRVIEDEERIVNHIESGTTNLGEPLYTSTTKVPRYDADGDVVGLVGVTIDVTERVTQREELERQNERLNEFAEVLTHDLRNPLNVANGYLDVLEATDDQTAIEEVANALARMESLIEEIRAFVLEGRLVEEPEAVDLRAVAREAWTTVETGETSLEFDGDLQLSADRARLRRLLENLFRNAIEHGRPGTATEGLTITVTSGDHEFAVEDDGVGISPDEAERVFERGFTTSGDGTGFGLAIVESIAEAHGWSISATESDAGGARFVFSDVVHADTGIGRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W735</accession>
    <name>R4W735_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447571.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13690"/>
    <dbReference type="EnsemblBacteria" id="AGN02677">
        <property type="protein sequence ID" value="AGN02677"/>
        <property type="gene ID" value="L593_13690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181297"/>
    <dbReference type="KEGG" id="sali:L593_13690"/>
    <dbReference type="eggNOG" id="arCOG08168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478977_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19786" checksum="4B145EE8DA343B72" modified="2013-07-24" version="1">MLTLKLLKWLLIVFGLLSALVFAGVLTAPAAAQSATNETDQQAIANGEQLNDDLVLVERELNNGRAELTFYAETRQRVTIYDASGFMHGGEPAQREAVIPANRTRTISVDSTAFRESRVVGIIYPGGHIGKVIRDDEPWVSNWGRVEVGLAILITAAISLTLAFGLRPIFKRLLGDQAGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W762</accession>
    <name>R4W762_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447591.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13790"/>
    <dbReference type="EnsemblBacteria" id="AGN02697">
        <property type="protein sequence ID" value="AGN02697"/>
        <property type="gene ID" value="L593_13790"/>
    </dbReference>
    <dbReference type="GeneID" id="16180829"/>
    <dbReference type="KEGG" id="sali:L593_13790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2821"/>
    <dbReference type="eggNOG" id="arCOG04774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302596_0_0_2"/>
    <dbReference type="OrthoDB" id="67509at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046147">
        <property type="entry name" value="DUF6149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19646">
        <property type="entry name" value="DUF6149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="21454" checksum="E0D4F6A7850AFA5A" modified="2013-07-24" version="1">MKLRQNARHWAFKAALTAPIVGGYTRGKLVDMHTGIFLDKADPDRRAERREHLDELFDATTDTYLAALDAGFPEAEAREITHVQANFDFYNHGWTEMMEIPIEELVPHYERYEAFFEQYEITIDDPLGTFAPPGGLPDAPATPENLEDPDHPHAEGGFADDAYVETENGDLVVGGQDQPADVSPGDAPGVEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W769</accession>
    <name>R4W769_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445682.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04185"/>
    <dbReference type="EnsemblBacteria" id="AGN00788">
        <property type="protein sequence ID" value="AGN00788"/>
        <property type="gene ID" value="L593_04185"/>
    </dbReference>
    <dbReference type="GeneID" id="16180853"/>
    <dbReference type="KEGG" id="sali:L593_04185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.851"/>
    <dbReference type="eggNOG" id="arCOG02882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020793_2_1_2"/>
    <dbReference type="OrthoDB" id="9314at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="241"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="587" mass="61348" checksum="5498A491D46A53FE" modified="2013-07-24" version="1">MTVRLVGEGPATEAVAAALGDVDVRVERGGLEGLADATLGVVSGTAGDDRFERATEIVANSASIDRWIAVEIGGIGGVPIEGIDAAIAGFAADGPCYRCLQQRVAANGPETADAPSADRSAVRMAGAIAGREVVRALAGEDRLSGRVIEVPHAERELVPVPGCDCGDGEIRGPSLDDRVPRSFEDRPLEETVARMDRSIDPRIGIVAEIGEAESFPAPYYLATLADTTGISDGDAPRQAAGVADDWNAALAKGVGEALERYDGALYRDAAFRTAASGELDDAVLPAAFAGAGEDAPGADADRSLPWVRGETLSNSESAQNESEDVWLPAAAVHFPPPEPRVLPSITTGLGLGSSGVGALLAGLTETIERDATMLAWYSTFEPLGLSVEDEAFERLAKRARSEGLTVTPLLVTQDVDVPVVSVAVHREDPWPRFAVGSAAGLDPTAAATGALEEAIQNWMELRSIGREQALDRQDAIGHFADLPDSAREFVDVESAVPASDVGPAEPPEGEAALDALLAALDDAGQDAYAARLTTRDLAALGFEAVRVLVPSAQPLFTGTARFGERAESVPESLGFESWLDREHHPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C2</accession>
    <name>R4W7C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02812">
        <property type="protein sequence ID" value="AGN02812"/>
        <property type="gene ID" value="L593_14365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14365"/>
    <dbReference type="HOGENOM" id="CLU_2748367_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7598" checksum="CD70D9B45990F367" modified="2013-07-24" version="1">MGSNQEGIAGLAILFTMILIVVAFYQILISGADSQDTVLVWFANRPNLFLVILLVLLVFGAALTAMQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F0</accession>
    <name>R4W7F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445827.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04920"/>
    <dbReference type="EnsemblBacteria" id="AGN00933">
        <property type="protein sequence ID" value="AGN00933"/>
        <property type="gene ID" value="L593_04920"/>
    </dbReference>
    <dbReference type="GeneID" id="16182784"/>
    <dbReference type="KEGG" id="sali:L593_04920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1005"/>
    <dbReference type="eggNOG" id="arCOG01376">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="335" mass="36689" checksum="90931E54DD4E5FC8" modified="2013-07-24" version="1">MTATPTADDHDVGDTPTVAVTGAGGYIGSRVLQIFQREHPEWELTAIDNGYRSQVWSVGDVDIDHVDIRDRGRLEDALSGADVVVHLAAVSGVDDCDENADLAYEVNVTGTSNVAWFCRKTGAAMAFPFSMAVLGDPETFPITADLPRDPMNWYGRTKAISEGDIQAFADGAFPAHLFMKSNLYGDHLVDDTVVSKPTVINFFVDRALSGETLTVYEPGTQSRNFVHVKDVARVYLHSTERLLERLADGETGAETFEVASDEDPSVMSVAEQVQSIAAEETGTEPPVELVENPRSAETMVEDFAVDTSRIREELGWEARHDVAESVRELLAREEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J1</accession>
    <name>R4W7J1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rps9p</name>
        <name evidence="5" type="synonym">rps9</name>
        <name evidence="9" type="ORF">L593_05220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445887.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05220"/>
    <dbReference type="EnsemblBacteria" id="AGN00993">
        <property type="protein sequence ID" value="AGN00993"/>
        <property type="gene ID" value="L593_05220"/>
    </dbReference>
    <dbReference type="GeneID" id="16181277"/>
    <dbReference type="KEGG" id="sali:L593_05220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1066"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OrthoDB" id="115425at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_S9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="131" mass="14478" checksum="9396B090EAC14C8D" modified="2013-07-24" version="1">MVTNTSGKKKTAIARATVREGEGRVRINSEPVELLEPETARLKVLEPFRVVDGIRDDVDIEVDVEGGGVIGQADAARTAIARGIVEHSGDAELRDAYMEFDRTLLVNDVRRSEPKKWGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7J7</accession>
    <name>R4W7J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="3">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.8.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445897.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05270"/>
    <dbReference type="EnsemblBacteria" id="AGN01003">
        <property type="protein sequence ID" value="AGN01003"/>
        <property type="gene ID" value="L593_05270"/>
    </dbReference>
    <dbReference type="GeneID" id="16180538"/>
    <dbReference type="KEGG" id="sali:L593_05270"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1076"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_2"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="302" mass="33622" checksum="F4763BDD0734B3C3" modified="2013-07-24" version="1">MALRSTPEDAFDGVPNYDYEPRYVSIDAPESPEMAYVDTDPAGDAAETFLCLHGEPTWGFLYRTMLPTLAERGRVVVPDFIGFGRSDKYTEREAYTYRLHYDALEQFVAALDLQDVTLVCQDWGGILGLPVAVNNEERFARLVPMNTGCPTGADEMAEEWYEFRDFVESVDELPIGMLIANATVSDLDEEVLAAYEAPFPDEELKAGAREWPDMVPRADGGDGAEITAPAREKLGEWEKPAFVLFGDSDPITGPARDPLRELIPTASEEPDVWIEDAAHFLQEDAGEEIAEEIVAFVDRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K5</accession>
    <name>R4W7K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CopG/Arc/MetJ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445907.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05320"/>
    <dbReference type="EnsemblBacteria" id="AGN01013">
        <property type="protein sequence ID" value="AGN01013"/>
        <property type="gene ID" value="L593_05320"/>
    </dbReference>
    <dbReference type="GeneID" id="16181310"/>
    <dbReference type="KEGG" id="sali:L593_05320"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1087"/>
    <dbReference type="eggNOG" id="arCOG02836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194986_0_0_2"/>
    <dbReference type="OrthoDB" id="123117at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="8007" checksum="4F481553A03B92A0" modified="2013-07-24" version="1">MTEYTTVSIPADLAERVDETIEGTSFSSTSDLVRFLLRSIVIQHERRGELTEAEFQEIAEQLQDLGYLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K8</accession>
    <name>R4W7K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PfpI-ThiJ-DJ-1 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445912.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05345"/>
    <dbReference type="MEROPS" id="C56.A06"/>
    <dbReference type="EnsemblBacteria" id="AGN01018">
        <property type="protein sequence ID" value="AGN01018"/>
        <property type="gene ID" value="L593_05345"/>
    </dbReference>
    <dbReference type="GeneID" id="16181332"/>
    <dbReference type="KEGG" id="sali:L593_05345"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1092"/>
    <dbReference type="eggNOG" id="arCOG00769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_2"/>
    <dbReference type="OrthoDB" id="98884at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="21938" checksum="5305401D4FA80C70" modified="2013-07-24" version="1">MSGKKILQIAGDFVEDYENMVPFQALQMVGHDVHAVCPEKEAGDTVKTAIHDFRGDQTYLETRGHDFEITASLVEIDPADYDALVVPGGRAPEYLRTYDEVIETVQHFFEEDKPVATLCHGPQILAAAGVLDGREITSYPAVRPECERAGCSWVDGVVTDGNLVTAQAWPDHPEWLAQFLDVLGTDVEHGEPQTAAADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q9</accession>
    <name>R4W7Q9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2 4">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tmk</name>
        <name evidence="7" type="ORF">L593_00120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2 4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444873.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00120"/>
    <dbReference type="EnsemblBacteria" id="AGM99978">
        <property type="protein sequence ID" value="AGM99978"/>
        <property type="gene ID" value="L593_00120"/>
    </dbReference>
    <dbReference type="GeneID" id="16180970"/>
    <dbReference type="KEGG" id="sali:L593_00120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.24"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_3_2"/>
    <dbReference type="OrthoDB" id="114844at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="6">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGM99978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="203" mass="22195" checksum="6F13713E5D2023E5" modified="2013-07-24" version="1">MTDGLFVAFEGLDGAGTTTQARRAAAFVADETDRSPARSAEPTDGPVGTQIRRCLEGEIEFDPETLALLFAADRLDHLHREIEPRLEAGDVVLVDRYSLSSFAYQRADGVDADWLRTINARARPPDVTVFLDVPPAVCVERITADGRGADRFERVETLEAVDAAYREAIDAEREAGNDVRVVDGTQSENAVADEVTATIERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R9</accession>
    <name>R4W7R9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444898.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00245"/>
    <dbReference type="EnsemblBacteria" id="AGN00004">
        <property type="protein sequence ID" value="AGN00004"/>
        <property type="gene ID" value="L593_00245"/>
    </dbReference>
    <dbReference type="GeneID" id="16180446"/>
    <dbReference type="KEGG" id="sali:L593_00245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.49"/>
    <dbReference type="eggNOG" id="arCOG02590">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262606_0_0_2"/>
    <dbReference type="OrthoDB" id="13745at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CheA-like_dim"/>
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    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
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    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
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    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
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    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
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    <dbReference type="Pfam" id="PF01584">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01627">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM01231">
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    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00073">
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    </dbReference>
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        <property type="entry name" value="SSF47226"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="916"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
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            <begin position="396"/>
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        </location>
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            <end position="353"/>
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            <begin position="553"/>
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            <begin position="604"/>
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            <begin position="812"/>
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        </location>
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            <position position="44"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00000085"/>
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            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1256" mass="131221" checksum="8E7D032B602DDA74" modified="2013-07-24" version="1">MADYLEAFARESEEQITELNNALLEFENDPTDEAAMEQIFRTAHTLKGNSGAMGFDPAEELAHAIEDLLEAIRSNHVSVTPELMDAIFDGVDELDAMISEAVEEGEIQRAADDEIATLRAYAEAEGLAAPTDAAIEDLLDNVSARTDSEHSVYHVRLDVAGDPAVHGRAVVDALDDAFELLGTDPDGETIDTGDYDGTIDAAFASVVERAAVEAALDPVDAVSDQVITDATDRMDELTAETVAEPTDDAGDSTTEEPAESMDDVSVDELLSDDDVDQFDDLDEMAEEVGDTSEFEDLGDAGSFADLGITEDDVEIEGVDTADEEVTAAEEAETSESSADTDDVPADEGEVEDAASEFAQLKAEVDPVGFDELQDELADLEFDEYDSDDEVGFDELLDEDELEDDGSFAESTVTASAAEDAAADAPATSAVADDDAGDAAETAGGAESAEDLGSDATAEDLFGGVSEETDEGAMAEAEDPATADAAVDIDEATTEAQTGGAALDDVVAESDDAVAGSDDTAAESDDAPVESGDSPADVGTSTAEAGASAPDTDEPAADVEESVVDAEEPAGDTDVLPLDAEEPAVDADDTVAEPDDAAVEGDTTSAATDDEDFDAAQVLDAESLDESAQSFGEGGMDLSDSEESTADEDVPTADEELDLDDSFGEMEADAAAEAAAADAEATDAADDAPDDGFDLGSEDVDFGVGSVAGSEESPEDATDEGVAVGGALEDDSFGSDVTTDSLGAEASADVDAAESEAAEAVDGFGDADDGVLDLDGDVGGSDAPPAGDEGTLEPVETEDVGPGARITDDAESSFEGEVDELGGSLDDSDADTLEDPGFSDATETEADDGPDVDEDRLDRIRSLGVPSRDADAEARAAGTQSIRVDVESLDRMLNMVEGLVTSRARLRRALIENEPREVLEDELDDLEDVTSELQDTVMDVRLVPLRTAVNKLPRIVRDVAREEDKQVDFEMVGEDVQLDRSILDEIGDPLVHLVRNAIDHGIETPDVREESGKPAEGSVELRATRERDRVTITVEDDGAGIDADAVRDAAVEEGIHTRSEVDSMDDEDVHELIFHAGFSTAAEVTDVSGRGVGMDVVAETVDRLDGSVTVESEPGEGTTITMELPVTLAIAEVLFVDVGGEEYGIPIKNVDEIGPVVGVETQDGQEVLVSDGGEDRRQLIRLDEALSTPERSDPNAGMLVHLRDDVREAAIHCDQVREQQEVVVKPFEGVLSDVPGLGGASVLGDGDVVTILDVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7S4</accession>
    <name>R4W7S4_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
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            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00019.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00019">
        <property type="protein sequence ID" value="AGN00019"/>
        <property type="gene ID" value="L593_00320"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.64"/>
    <dbReference type="eggNOG" id="arCOG04525">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069530_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="32677" checksum="CD3EE35555FCB3FD" modified="2013-07-24" version="1">MDDALPEQRFLDREWDVCIVLDACRYDRFAAKYQDYLVGDLQRLVSPGSSTPEWAYRTFTDHHDVAYFSGNPFVNGLGIPLNELKWGASCDYDWAASDHIETVIDVWKEGWDDDLGTVPPGSLAQALERHRESAEAAERIVLHYMQPHAPYLDRETSGKLSTIKNGIQSQGAEADGGDPGIVDRIGDAVRPRVEQFLEGRRLAQKAGMWVELDKRGILTSGTRATALQHYDRNLEIVLESVTSLIPELEGDVVVTADHGEAFGEHGIWEHHIETHIPPLIEVPWIEVEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U4</accession>
    <name>R4W7U4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444978.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00084">
        <property type="protein sequence ID" value="AGN00084"/>
        <property type="gene ID" value="L593_00645"/>
    </dbReference>
    <dbReference type="GeneID" id="16182397"/>
    <dbReference type="KEGG" id="sali:L593_00645"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.131"/>
    <dbReference type="eggNOG" id="arCOG08171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406244_0_0_2"/>
    <dbReference type="OrthoDB" id="116198at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="10046" checksum="CA630CFCDD6CF917" modified="2013-07-24" version="1">MAPTVGDLRNEIRLAVDRFERPDSAGFTKESLAAICEAVDYEIDHDDYPPTSQMRAGILSSIGELESDDPEAVGSSFRKAELEAIADALDADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W0</accession>
    <name>R4W7W0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06480"/>
    <dbReference type="EnsemblBacteria" id="AGN01243">
        <property type="protein sequence ID" value="AGN01243"/>
        <property type="gene ID" value="L593_06480"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1321"/>
    <dbReference type="eggNOG" id="arCOG06179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055092_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="2">
        <location>
            <begin position="78"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="421" mass="44430" checksum="9AC17ED80A8295C6" modified="2013-07-24" version="1">MTPADFPRFARATRSRDDPRVSDVADATRRALDAIDGLDSLADGAEVAVTAGSRGIHDVPEVLATTVSALDERGLSPFVMPAMGSHGGATAAGQLETLESLGITEETIGCEFRSSMAVEQVGEDEDGRPVFAARDALDAEAVLLVNRVKPHTDYAGPYESGLAKMAVVGLGKHRGAEAMHNAALARGFQEVIPERAEILIEETPVVGGLALLENANERAADIVGLDAGEIMEREPALLERAADLLPTLPVDDLDFLLVEEMGKEVSGTGLDTNVVGRQLFHGQPEPADAIDVTRIYVRSLTPASHGNALGMGLADFVHRDLVADVDFGDTYVNIATSGEPVRAKLPFVVPSDATALTLANSTTGVQSIGDLRAAVIENTLEPDDLLVSAPVAEELAEHPDVEVGPLEPLSFDENGDLELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W3</accession>
    <name>R4W7W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06530"/>
    <dbReference type="EnsemblBacteria" id="AGN01253">
        <property type="protein sequence ID" value="AGN01253"/>
        <property type="gene ID" value="L593_06530"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1332"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_14_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="177"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="41447" checksum="78F43FCFBA454C22" modified="2013-07-24" version="1">MSGDGTEDGAGGGDEDDYGLAEIVDLEETTAPTYPYQPQDPDDYDPGIALIGTGGISEQHLKAYTAAGYDVVALCNRTVEKAEDRREEFDLDADVYADYEEVLELDAVEVVDVTPHPEQRVPIVEDAIRAGKHVLSQKPFATDLDDAERLVELADEYDVKLAVNQNGRWAPHFAYLRQAVADGLIGDVHGVACNVHWDHNWIGDTPLDDVEHIVLYDFAIHWFDMVTQLVEDPPERVYANYEPSPSQTASPPLLGSAIVEFDGAQVTLAFDADTKLGPEDRTVVTGGEGTLKSEGPDLEEQEVTVFTEDGYATPELDGAWFPDGFHGAMAELLSAIEADREPTNSGRDNLATLELTFAAVASAEDGEPKTPGDVRRLPEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W840</accession>
    <name>R4W840_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histones H3 and H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_01680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445183.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="SMR" id="R4W840"/>
    <dbReference type="STRING" id="1333523.L593_01680"/>
    <dbReference type="EnsemblBacteria" id="AGN00289">
        <property type="protein sequence ID" value="AGN00289"/>
        <property type="gene ID" value="L593_01680"/>
    </dbReference>
    <dbReference type="GeneID" id="16180589"/>
    <dbReference type="KEGG" id="sali:L593_01680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.341"/>
    <dbReference type="eggNOG" id="arCOG02144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801751_0_0_2"/>
    <dbReference type="OrthoDB" id="108727at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="145" mass="15797" checksum="769A02EF73CCAD1F" modified="2013-07-24" version="1">MSVELPFAPVDTIIRRNAGDLRVSAEAAEELARRVEDRGADLAVDAAEHATADGRKTLMAEDFGVEATIDKNALELPVAPVDRIARLKIDGQYRVSMDARIALADILEDYADNVAEAAAILARHADRRTVKAEDVETYFALFDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W865</accession>
    <name>R4W865_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase</fullName>
            <ecNumber evidence="2">1.2.1.103</ecNumber>
            <ecNumber evidence="2">1.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argC</name>
        <name evidence="2" type="synonym">lysY</name>
        <name evidence="5" type="ORF">L593_07890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:52668"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="EC" id="1.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="2"/>
    <dbReference type="EC" id="1.2.1.106" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446417.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07890"/>
    <dbReference type="EnsemblBacteria" id="AGN01523">
        <property type="protein sequence ID" value="AGN01523"/>
        <property type="gene ID" value="L593_07890"/>
    </dbReference>
    <dbReference type="GeneID" id="16182001"/>
    <dbReference type="KEGG" id="sali:L593_07890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1616"/>
    <dbReference type="eggNOG" id="arCOG00495">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_2"/>
    <dbReference type="OrthoDB" id="51061at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043870">
        <property type="term" value="F:N-acetyl-gamma-aminoadipyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="36573" checksum="98F5AA0934754FC3" modified="2013-07-24" version="1">MTDETLTASVVGGTGFTGGELLRLLDGHPNFEIEEATSRSTAGKSVGYKHPNLRHLDLRFTDPEELASVDVIFAATPHGVSMERIDAFRDAADTVVDLSADFRLPTAEEYDEWYDGHTSPEYLDDAVYALPELTREELPGADLIASGGCNATATILGLKPLVDDGILSGDEQIVVDVKVGSSEGGAGGGEASSHPERSGVVRPYAPTGHRHEAEIEAYLGLDVSFTVHAVDMIRGASATCHVFPESPVSTGDLWGAYRGAYEEEPFVRMASGGGGVYRYPEPKAVAGSNVAEVGFEVDASNERLVVFSAIDNMMKGSAGQAVHAANVALGLEETAGLEATGLHPVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W898</accession>
    <name>R4W898_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445348.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02515"/>
    <dbReference type="EnsemblBacteria" id="AGN00454">
        <property type="protein sequence ID" value="AGN00454"/>
        <property type="gene ID" value="L593_02515"/>
    </dbReference>
    <dbReference type="GeneID" id="16182817"/>
    <dbReference type="KEGG" id="sali:L593_02515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.510"/>
    <dbReference type="eggNOG" id="arCOG04780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044555_0_0_2"/>
    <dbReference type="OrthoDB" id="47929at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="519" mass="55828" checksum="3622961E7832B8A6" modified="2013-07-24" version="1">MFDARERLRRLRHRLRRIERREQSALRRWIEHTDNLVHASVLLFVPLTIAAVTALANAVPSLSFLLFPPLASGAYTLFADPAGRYSSPIRFVAGLTIGSVCGWIALVTLGDPGSANVNAWAAMVAVLLTGTATWALDVEEPSGYSAALLLLVQEAPPLVYVFSVALASSIVAVVYVTWHDTIYERRAEVLYATTGRDDDVLVPMLGDSDAIARLGARIASGHDRGRLVLLGFANGAAGGVEETESWEATSNADSDGPEAEGESGQQEAGGATSEQQKQWRATTEQDDAEKPTGRREGAGNTTEDSAEDSPPNRQAEDALVKRLESRAAELRDATGANCQVVVARGSNLAAVTRETARETGCDLILAPFHGPDEEGLVTSLFSSPLDVAAARVDRRSWTQVLVPIRSAGDLAHRKVDLARRIAGPAGRVTVAHCIDSESDRRRAESMCANVVEPYEGRFTTLVARADVEDFLGDHAPANDLIVLGASTDRSPVSRMLSRPTYERVHTVDTDLLVVHAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B2</accession>
    <name>R4W8B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_08415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446522.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08415"/>
    <dbReference type="EnsemblBacteria" id="AGN01628">
        <property type="protein sequence ID" value="AGN01628"/>
        <property type="gene ID" value="L593_08415"/>
    </dbReference>
    <dbReference type="GeneID" id="16181300"/>
    <dbReference type="KEGG" id="sali:L593_08415"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_0_0_2"/>
    <dbReference type="OrthoDB" id="45571at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="109"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="38622" checksum="1FAC5AD659563DD3" modified="2013-07-24" version="1">MASDRLRDALADLGLSRTEIDAYLVVLEGGEATMRTVSERADVSQSYVYEIAGELADRGLITVDESVTPTMLRARPPAEAVEALSTRLSAFERAASERYAATGTEDAGFETIRSARTVRRRIERQIERAEEELYLVLPASELGNLRDLLIEARARGVTVYCMLTAPEPDTAFEGNRPATDWATVVRTWDGTPPMLVLRDGSGGVMGAHGLLTPGSDELDHAVAFGQPEVAGAFYGSSLGNVWPMGNQRAVAEPPALPARFDFFRSGVTAAAIHWQAGTELLADVVVVDGDGGGQRELTDVPVIGVRQSMVEPTEAAFPVESALQLATDEGDISVGGLSGGFGAYHEPFAANAVTLRRADASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B5</accession>
    <name>R4W8B5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydrofolate reductase</fullName>
            <ecNumber evidence="1">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445393.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02740"/>
    <dbReference type="EnsemblBacteria" id="AGN00499">
        <property type="protein sequence ID" value="AGN00499"/>
        <property type="gene ID" value="L593_02740"/>
    </dbReference>
    <dbReference type="GeneID" id="16180320"/>
    <dbReference type="KEGG" id="sali:L593_02740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.555"/>
    <dbReference type="eggNOG" id="arCOG01490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_2"/>
    <dbReference type="OrthoDB" id="94053at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="18705" checksum="447CC56568FEDDE0" modified="2013-07-24" version="1">MVEAPSDLDVYLIAAVAANGVIGKDGELPWEIPEDMAHFKETTTGHPVIVGRRTFENVLAGLGGPLPGRTNVVLSRSNPDLPDDGSIVVAESIDDALAAAASAAAERGVDRAYVMGGAAVYDALLDRADGMVLTEIDEEFEGEPTFPGWPLADDWVEIDRDERDGFAFVTYERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C5</accession>
    <name>R4W8C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446552.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08565"/>
    <dbReference type="EnsemblBacteria" id="AGN01658">
        <property type="protein sequence ID" value="AGN01658"/>
        <property type="gene ID" value="L593_08565"/>
    </dbReference>
    <dbReference type="GeneID" id="16182458"/>
    <dbReference type="KEGG" id="sali:L593_08565"/>
    <dbReference type="eggNOG" id="arCOG06328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2712703_0_0_2"/>
    <dbReference type="OrthoDB" id="120466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="69" mass="7442" checksum="E9FED98AEE3073C1" modified="2013-07-24" version="1">MSILGTVKEVFQASNQATTTDESKGAYWCHDCQERVRDVDVKGESTPDCPSCGESMEFERSTGTAGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C9</accession>
    <name>R4W8C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01668">
        <property type="protein sequence ID" value="AGN01668"/>
        <property type="gene ID" value="L593_08615"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08615"/>
    <dbReference type="HOGENOM" id="CLU_948698_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="29548" checksum="CBE49671316FF3D2" modified="2013-07-24" version="1">MKLVSSDGDRSERGGWGAVFVASMLCLAVALGIVVARAAAVPIVGETIRWPTLFAIPLVGGLVAGARFPGNRSSAVGSALLGAVWLGAIAFHVGLVSLFESPIVSPASSWLIFTVAWTPFAIVFACIGGLLGSGLAARWIGRSEDVDADALVDGGETVPLGRIARATLEGVGVMVAVAVAGVFVGPLAVIFGAPFAGGFVAGGRAPGGTLVGVFTGLLAGVLYVVTLAVAFVLWLRSLTWVGYGIGFVIVFYFLALLLTLVLSGLGGLFGALANDSSEDADAQEGAAESATEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8F3</accession>
    <name>R4W8F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445508.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03315"/>
    <dbReference type="EnsemblBacteria" id="AGN00614">
        <property type="protein sequence ID" value="AGN00614"/>
        <property type="gene ID" value="L593_03315"/>
    </dbReference>
    <dbReference type="GeneID" id="16182867"/>
    <dbReference type="KEGG" id="sali:L593_03315"/>
    <dbReference type="eggNOG" id="arCOG06413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718285_0_0_2"/>
    <dbReference type="OrthoDB" id="104835at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="152" mass="15921" checksum="3FCA42BBA0E233F2" modified="2013-07-24" version="1">MVVLAMVEDFLLISSDGSGLPDFESSRAFVQVITWSFYDAHAVPITGGTGDFNHLMLPDGGRPTTAYYLIPALGPFVGGRSIARSNGHVDMSNEALGTLGTMVVAGYGGVMFLGVFLTEWCGIAATTGEGVLFAAIGFPIVFGFLGGYLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K9</accession>
    <name>R4W8K9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trk active potasium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446797.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09790"/>
    <dbReference type="EnsemblBacteria" id="AGN01903">
        <property type="protein sequence ID" value="AGN01903"/>
        <property type="gene ID" value="L593_09790"/>
    </dbReference>
    <dbReference type="GeneID" id="16182672"/>
    <dbReference type="KEGG" id="sali:L593_09790"/>
    <dbReference type="eggNOG" id="arCOG01960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035216_0_0_2"/>
    <dbReference type="OrthoDB" id="29208at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="113"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="341"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="462"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="544" mass="58355" checksum="8F58BEE756BA0AA3" modified="2013-07-24" version="1">MVSRRRQTAIYLAVLVGSMLAFTAIYWYGMGAFEDRSVTVLHSLQVVVETYTTTGYGSDSPWASEQMNLVVIAMDLLGTLLIFLALPVLLFPALQDALATAVPTSVDSELSDHVVIVSRTDRLDPLLSELGSWDVEHVLVEPDRERALERYEAEGDAIHAQPDEIEGLEAANLESARALVVDVEDRIDASIVLTAREIDESVRIVSVVEEPDRAAYHELAGADEVVSPRPLLGERLAGLVTTAITPDLGEAAGLGEDFHVVELPVPRDSELVGKTIAESGLRERAGVNVVGAWFRGDFETPPPPDARITSGTVLLVTGSDDDIHRLSELSTGSPRPYTRGDTIVVGHGEVGKAVTSALAEEGLPYTVLDVRDDPDVDVVGEATDPEALERAGIENATSLVLAIPEDEETEFATLVARDASHDLNVAARADQARTVRKIYRAGADYVLSLDTVTGRMLASTVLEDEDVLATDTQVEVVRISAGTLAGKTLEGAEIRSQTGCTVVAIERDDEVVTDLGPDFRIQPGDDLIVAGTGPGVNAFTDRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N3</accession>
    <name>R4W8N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445663.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04090"/>
    <dbReference type="EnsemblBacteria" id="AGN00769">
        <property type="protein sequence ID" value="AGN00769"/>
        <property type="gene ID" value="L593_04090"/>
    </dbReference>
    <dbReference type="GeneID" id="16181621"/>
    <dbReference type="KEGG" id="sali:L593_04090"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_1_2"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026469">
        <property type="entry name" value="Peripla_PGF_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04281">
        <property type="entry name" value="peripla_PGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="67"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="36412" checksum="BFD0D0909E51472C" modified="2013-07-24" version="1">MTRTSKALVAALVVVAALVGGVGHVAAADAVGPTTAEAALAQENCSFPVTLTDASGTDVTLDESPEDVVVLGASSAQTVWELGEQDRVVGMPVGPSTAYLDGSQDRTHVLDGIRVQTETVVDLDPDVVIAPGGIIAPEDVQALRDAGLTVYVTNDGNSIQDVRDRVTSTGRLLGACDAADDTVSWMDERLAVVNETTQGVDRPSVFYWLGGGYTAGSGTFQGELLQLAGADNAAANMGISGWAAAEPEAIVAEDPDYILVSEGTTLPEDHPVQQTTAVQEGNVITVNGNYWNQPAPRIVLAVEEVTQQLHNESYQEATSDSEGSSGDALPGFGVGAAAIALLGTVLALQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T8</accession>
    <name>R4W8T8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_04850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445813.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04850"/>
    <dbReference type="EnsemblBacteria" id="AGN00919">
        <property type="protein sequence ID" value="AGN00919"/>
        <property type="gene ID" value="L593_04850"/>
    </dbReference>
    <dbReference type="GeneID" id="16181119"/>
    <dbReference type="KEGG" id="sali:L593_04850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.991"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="253"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="452" mass="46260" checksum="32D172CAEDC825A6" modified="2013-07-24" version="1">MFGTSGVRGRFGSDVTADLALSIGRAVASDGADRIVLGRDPRTTGDLLADAAAAGARECGADVIDLGLAATPTIARSVGWQDADAGIAVTASHNPPEDNGLKLWEPSGQAFGKDHREQIARTVQNGEAGSADWEAVGSRTAWNGAEDRHVAAIVDAIAAEPDSGLADLEVVVDVGNGAGGITVRALRELGCSVTALNERPDGHFPSRPSEPTEENLAALGSVVGAADADLGVAHDGDADRMMAVDETGRFVGGDALLALFATDAVEGSAAGSQVAAPVNTSLAVDDALAGVGADLVRTRVGDVFVAERASQPDVGFGGEPSGAWIWPGETLAPDGPLAACRLAKMVADGGPLSAMVGEIEQYPIRRDSREVAEKAATMERIRSAATDEYADAADSDVETLDGVRVTTDDGWFLVRASGTQPLIRVTAEAREAGRADELLAAAHGLLDDAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W927</accession>
    <name>R4W927_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase xerd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446038.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05975"/>
    <dbReference type="EnsemblBacteria" id="AGN01144">
        <property type="protein sequence ID" value="AGN01144"/>
        <property type="gene ID" value="L593_05975"/>
    </dbReference>
    <dbReference type="GeneID" id="16180535"/>
    <dbReference type="KEGG" id="sali:L593_05975"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_840966_0_0_2"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="330" mass="37558" checksum="C6CB96BACD374142" modified="2013-07-24" version="1">MNDAEFNRVIKRVKNSKTEATANQYVPKIREFRTWLTEGEKDDEGNVLREQKPFEEADVIDVEDWLGEQDEKYSNASSVGKADAALVAAFDELNKLITSGRIDGEPWPRDTPADRADYTPNDTSTIKSRELKQDLHYLKPDEVDQMVEETDKLRDGLIIRLLFQTGLRVSELTDIRLSDLDEESRSIAVRGKGRKNRTVFYQPSLALPMHIWLTDRRPAVFYAEESEYLFPTSHSECITRAAVTEMVREVAEQAGIQEVYGTTTDGVERHSVTPHVLRHSFAMAALDNGWDVYTLSQALGHASTEITTSTYLHDDEEQVREAYQLRGPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W928</accession>
    <name>R4W928_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11800"/>
    <dbReference type="EnsemblBacteria" id="AGN02303">
        <property type="protein sequence ID" value="AGN02303"/>
        <property type="gene ID" value="L593_11800"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2429"/>
    <dbReference type="HOGENOM" id="CLU_923226_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="31386" checksum="8245D58C83828437" modified="2013-07-24" version="1">MPHYSLGTAVQRKLLTLGAVIVLVTMAGCSGGILGGGGGSGTPDWCHQNAFQELSASGGEMNENVSASVQGMTDREGNDVCQVRYEAPSDSNSMYQRVDLFYNEDQSYVVMVYYDSHGNQVGEVDLSGMVGGTDSGGTTDDSTGGTTDDGTDSTTGDSTGGTTDDSTGGTSDDGDSTTDNSNPSPVVGTLSYGQTVNAELTEDDGVAGEWRDANADAYEFQGSAGDSVVISMTSDPVDTYLILEGPNGERVAVNDDNGYSLDSEINYTLQQSGTYTIWATTFTLDNYAGGEGPYTLTLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W943</accession>
    <name>R4W943_9EURY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01174">
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        <property type="gene ID" value="L593_06125"/>
    </dbReference>
    <dbReference type="GeneID" id="16181640"/>
    <dbReference type="KEGG" id="sali:L593_06125"/>
    <dbReference type="HOGENOM" id="CLU_932625_0_0_2"/>
    <dbReference type="OrthoDB" id="49057at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="34280" checksum="620B49968E3A1057" modified="2013-07-24" version="1">MKWETLQSFLSKQGVFLIHDTTEQRSQFGLLRCLPALNRLGIEEFTYPWRWRQLQSGDGRGLFSYEYSLLQNIEYEEQMLAALTTQYYEDETQHSIGGLINRWQEMGTMVVVADEKQFQTQQGLRPLYHEPFAIAQRPYDDVYDALNQWYNDQGFDFPLTDTQNVFLQDNAILYERVAGETVTQTTELFSLLNDAPYLPLYDAIAAAFQSHDGPGTSPKKDDALQNLASWLRRRIEWDSSTAMRVVRSLNSTVADNTRAFDPAAVAQDASMSDARREARNLDSTPLGQTYKAWLQRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A7</accession>
    <name>R4W9A7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Cupin</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06910</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN01329">
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    </dbReference>
    <dbReference type="GeneID" id="16179893"/>
    <dbReference type="KEGG" id="sali:L593_06910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1412"/>
    <dbReference type="eggNOG" id="arCOG02998">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="162" mass="18365" checksum="A979F4A99F8F13EB" modified="2013-07-24" version="1">MEKVTIDEVEIEVNPLQVHDVRRPVTKALDADHVAMNYFELAPGDSFSGGLHTHHDQEELFYVESGTAEFEVGRDREIETVEAGEVIRFPPGEFQKGYNPEDAEEDVVGWAIGAPGARHDWDEIESVVYCRVCEEERAHGTRINEEGRFEFTCTECGTTFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A8</accession>
    <name>R4W9A8_9EURY</name>
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            <taxon>Natrialbales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_12895"/>
    <dbReference type="eggNOG" id="arCOG04577">
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    </dbReference>
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    <dbReference type="OrthoDB" id="97297at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16926" checksum="346C15CF75D8C0D1" modified="2013-07-24" version="1">MTLDVEIPDPPTLHGPQDPGDYDSVEEIDAHPGEQPERDTLATALESGAWGEAFDDWCQETYLSEEQFQAVLDLGLIEGFDFYLNPSAGDVGYRSPTVPDDLPAPYDETFERSDRQDVVEALDELGRTVSEVLENDYLVRTGEEFGFNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9F1</accession>
    <name>R4W9F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02613">
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        <property type="gene ID" value="L593_13370"/>
    </dbReference>
    <dbReference type="GeneID" id="16180574"/>
    <dbReference type="KEGG" id="sali:L593_13370"/>
    <dbReference type="eggNOG" id="arCOG02452">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102056_0_0_2"/>
    <dbReference type="OrthoDB" id="76153at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19124" checksum="5AAE23990BF5D467" modified="2013-07-24" version="1">MDEKPPQQITHRPGTCELLLAPGRTAGTAALGDRLTDPDTSTAVLYVTTGNADDAVDRLRTRSVPAEAIGVVDASGADRTPDGVAESAVVGGPGSLSALGIAVSDVLERLSHRFDRVVIGFDSTTDVLDAAPLPATFRFFHVLCGRVRTGEAVLLATIDSTAHDEETRRTIAELFDLATTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H0</accession>
    <name>R4W9H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13570"/>
    <dbReference type="EnsemblBacteria" id="AGN02653">
        <property type="protein sequence ID" value="AGN02653"/>
        <property type="gene ID" value="L593_13570"/>
    </dbReference>
    <dbReference type="GeneID" id="16181348"/>
    <dbReference type="KEGG" id="sali:L593_13570"/>
    <dbReference type="eggNOG" id="arCOG02894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629569_0_0_2"/>
    <dbReference type="OrthoDB" id="110416at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="85" mass="9554" checksum="A9CF2F9AAE5A0344" modified="2013-07-24" version="1">MATLDIDPRFDVHEYRSSLKLLRQDDASMTLSNREELACPACDRQFDRLFVSEEPEVTFASAPSGPICIARTDEQVLVLTHESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M3</accession>
    <name>R4W9M3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14245"/>
    <dbReference type="EnsemblBacteria" id="AGN02788">
        <property type="protein sequence ID" value="AGN02788"/>
        <property type="gene ID" value="L593_14245"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14245"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2916"/>
    <dbReference type="eggNOG" id="arCOG04247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="503" mass="57255" checksum="1C0DD399B9B90740" modified="2013-07-24" version="1">MSDSATTASPDETYEEFLDRVKRRYNVNAAAGVLRWDQEVMMPEGGTTARSGQLSALSAIGHELLTDEEMGEWMTTLRDADLDDDQQPVVREVGREYDRATSVPTDLVEEISAATSEAHPEWTEAKENSEFETFAPSLKRLVELNREYAEHIDPDRPAYEVLFEEYEPYLGLETADRVLTELREGLVPLIEDVRESDVELATPFDGEYPEDAQEELARTVLDELGYDWEHGRLDTAPHPFSSGTQFDARVTTRFDESEPLGALLSTIHEFGHARYTQGLPKDQYGTPLGNSRDLTVHESQSRFWENHVGRTTQFCERLVPLVQEHLPGAEDLTAQELFEALNEVYEDNLIRVEADELTYHLHIVARYEIEREMISGDLAIEDVPEVWDDTYEEYLGIRPENDAEGCLQDIHWSHGSFGYFPTYSLGSVLAAQIDAAMREDLDVDGLVADGEFEPIADWLETEIHQHGSRYTTNELIEKATGEPLTAEYFLDYVEEKYGELYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N5</accession>
    <name>R4W9N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08570"/>
    <dbReference type="EnsemblBacteria" id="AGN01659">
        <property type="protein sequence ID" value="AGN01659"/>
        <property type="gene ID" value="L593_08570"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08570"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1755"/>
    <dbReference type="eggNOG" id="arCOG07499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200164_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6471" checksum="387C85BE3CF0CD54" modified="2013-07-24" version="1">MQSRGDPRVHFVMNLVLSGLFAYIVLWGLDLLGVVGFTLTRLATATLLLMVLTYIMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q1</accession>
    <name>R4W9Q1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="8" type="ORF">L593_14695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447767.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14695"/>
    <dbReference type="EnsemblBacteria" id="AGN02873">
        <property type="protein sequence ID" value="AGN02873"/>
        <property type="gene ID" value="L593_14695"/>
    </dbReference>
    <dbReference type="GeneID" id="16181475"/>
    <dbReference type="KEGG" id="sali:L593_14695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3000"/>
    <dbReference type="eggNOG" id="arCOG02202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058152_0_0_2"/>
    <dbReference type="OrthoDB" id="23481at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="390" mass="41747" checksum="CCF4B9A26F7A7713" modified="2013-07-24" version="1">MKIALIGVGNAGGKIADELFRYQNESGRDLCRAVMAVNTAGTDLAKLDTIPEEDRLLLGQTNGQVKGHGVGADPDLGATVIEEDLHEVERALSEVPIYDVDAFIVVAGLGGGTGSGGAPVLGEMLNETYEEPVFGLGVLPSTEEGGRPSYNAARAFPSFVEATENLIVFDNDAWRGNADSIGGGYERTNREIAKRIETLLSAGNVGEEVSENAMDASDVRRTLATGGISTIAYAETGIDRSTFESRSFLNRFRKNGTQEDSDKAKKISGLVRQAVQSRLTLPVNVESAERSLIVIAGPPEEFSRKGLESARRWVEDQTNSMEVLAGDAPIPSADTVSAVVILSNVTDVDRVDELQSQALDARDSISEQKSDRESEIEDLITDDNDEISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V0</accession>
    <name>R4W9V0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="9">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446733.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09470"/>
    <dbReference type="EnsemblBacteria" id="AGN01839">
        <property type="protein sequence ID" value="AGN01839"/>
        <property type="gene ID" value="L593_09470"/>
    </dbReference>
    <dbReference type="GeneID" id="16182718"/>
    <dbReference type="KEGG" id="sali:L593_09470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1950"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_2"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="11"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="374"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="496" mass="51116" checksum="B02198333BE2F99D" modified="2013-07-24" version="1">MVVGDVSTGTEVLVIGGGPAGYTAAIRAGQLDLDVTLVEQSDYGGTCLNDGCIPSKALITATDLADRAGDAEHMGIHADPAVDLGAMMEWKDGVVDQLTGGVEKLCKANGVNLIEGTAKFAGEGRARVAHGGEGQGSETIEFEHAIVATGSRPMSLPGFDFDDDPILDASQALALESVPESMLVVGAGYIGMELAGVYAKLGTDVTIIELLDSALPAYEDDLARPVKRRLESHGVDFHFGLGAEDWTENGDGTVTVTAAAMDGGGAEVAADGGEAAEATEADAATSEQFVAENVLVAVGREPVTDTLDLESVGLEPNEQGVLETDHRAQTDVEGIYAVGDVAGEPMLAHKGSAEGKVAAEVIAGEPAALDHQAIPAAVFTEPEIATVGLTEDEAFEEGFDPVVGEFPFRASGRSLTADESDGFVRVVADAETEFLLGAQIVGPDASELIAEVALGIELGARLEDVASTIHTHPTLAEAVMEACENARGEAIHTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X4</accession>
    <name>R4W9X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMP dehydrogenase/GMP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446853.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10070"/>
    <dbReference type="EnsemblBacteria" id="AGN01959">
        <property type="protein sequence ID" value="AGN01959"/>
        <property type="gene ID" value="L593_10070"/>
    </dbReference>
    <dbReference type="GeneID" id="16180898"/>
    <dbReference type="KEGG" id="sali:L593_10070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2076"/>
    <dbReference type="eggNOG" id="arCOG00612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_3_2"/>
    <dbReference type="OrthoDB" id="39816at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="3">
        <location>
            <begin position="7"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="38493" checksum="B991757BC80194CF" modified="2013-07-24" version="1">MDDVRTGLSYGDALLVPQRSPVESRSDVDLSTHLTDGIELETPLLSAPMDTVTESTLAIALSEAGGFGTIHRFLDAESQAAEVRAVTDAGARCGAAIGIDEDYLARAEAVLDAGAACLVVDVAHGHLERCLDAVADLRDAFPDAEIVAGNVATKRGVRDLAAAGADAIKVGIGPGSHCTTRVVAGAGVPQLTAVDECADAAEAVDVRIVADGGIRSSGDAVKALMAGADAVMMGSLFAGTAEAPSEVVTIDGTRYKRSRGMATTAAAEDRNDKGGTGDDDGAATDGDLAPGADALDDHLPTADEGVAGYTPYKGPVAEVVTEFAGGIRSGLSYCGGETIPAARANAEFVAVAGSAKEREGAHGDHEWESVSVDSVGTAGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA42</accession>
    <name>R4WA42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein NosY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_11780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447193.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11780"/>
    <dbReference type="EnsemblBacteria" id="AGN02299">
        <property type="protein sequence ID" value="AGN02299"/>
        <property type="gene ID" value="L593_11780"/>
    </dbReference>
    <dbReference type="GeneID" id="16180873"/>
    <dbReference type="KEGG" id="sali:L593_11780"/>
    <dbReference type="eggNOG" id="arCOG02440">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="30173" checksum="B7B6D89DE4AAA9B3" modified="2013-07-24" version="1">MSVNVAAIRAVARKEFEDQIRNRWILAVTVIFVVLTIAASYLTGGQTAGNEVFGGLEGTVVTLISLSSLLIPLIAIMLGYATISGEVESGAMGLVLSYPVSQGEVLIGKYLGLSAVLVVSTIAGFGAGGVVIAAVAGTANAGAYLVFILLAILLGLLYLSLSISFSAYCKRRSTSIASGILLFFWSTIYGTIVLGIHLSTGGSIEDFFGPEVTFPDWLWRSLVLSPMDMHQQAVLLAFGITETFGYNVDPPAFITIEYLVAVQLVWTIVPLGLAYIFFLRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA86</accession>
    <name>R4WA86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRTGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447413.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12900"/>
    <dbReference type="EnsemblBacteria" id="AGN02519">
        <property type="protein sequence ID" value="AGN02519"/>
        <property type="gene ID" value="L593_12900"/>
    </dbReference>
    <dbReference type="GeneID" id="16180238"/>
    <dbReference type="KEGG" id="sali:L593_12900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2645"/>
    <dbReference type="eggNOG" id="arCOG00099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040984_0_0_2"/>
    <dbReference type="OrthoDB" id="67811at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="37922" checksum="44ECB056E1CA79EA" modified="2013-07-24" version="1">MSDTLLVTALADGTGKTAITVALGLHAREREEDVGYMKPKGTRLRSRVGKTIDEDPMLARDLLEFEAEMHEMEPVVYSPTFVEQAVRGQADPEDLQRQVKEHFQTIASGRDRMFIEGGGTLTTGGIVDLTDADIADLVDAEVLVVAGYDSPGDLDDVLAAVDSIGQDRLRGVLFNAVDDSAYDGLEEDAVPFLEERDVPVHGAVPRVQELAGVTVGDLADELGARVLTNVPTDEYVERFSVGAMGADSALRHFRRTRDAAVITGGDRSDIHTAALEAPGVNCLLLTGGHRPSSAVVGKAEEKGVPIIVVQTDTLTTIDRAEKVVSGGRTRDAGAVERMQELLGDHADVDAILNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC4</accession>
    <name>R4WAC4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L593_13850</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13850"/>
    <dbReference type="EnsemblBacteria" id="AGN02709">
        <property type="protein sequence ID" value="AGN02709"/>
        <property type="gene ID" value="L593_13850"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2834"/>
    <dbReference type="eggNOG" id="arCOG00305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="21">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="20">
        <location>
            <begin position="371"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AGN02709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="600" mass="64655" checksum="C5F5277BD6C283D9" modified="2013-07-24" version="1">MSDDQTEVTDADGELAFDPTGVSNDELAGLLYEFADRLEAQDVEYKPTAYRRAADNVRDYPGSIAGLAAQDPETVERVDRVGEAIAEKLVEYLETGEIEELETLRDELPVQMDDLTAVEGVGPKTVGTLYRNLGVRTLADLEAAAEAGEIQKVKGFGPKTEQNILDNIAFAKEARGRERLGNARPVADRLLEAMRDAEPVQQAEVAGSIRRWRPTIGDVDLLVAADPDEAEDAVDAFLDLADEEMQSGTTKASARLDGQQADLRVVAPDQFGSALQYFTGSKEHNVQLRNYALDRGVSLNEYGAFDVSDPDVDPGDARDAGERLAGDTEESMYDVLDLPWMPPEIREGRGEVEAAADGTLPEVVAEGDVRGDLHVHTEWSDGRETIESMAQGAADFGHDYVAITDHAEGPGVVAGMGLTPEELREQQEAVAEVDADAEIDVFHGTETNVDVDGDVSTPDDVLADLDVVIASPHSGLDGEATNRLVDAIEHPHVDVLGHPSGRLLNERSGLEFDASRIGEAAAENGVALEINANPARLDLWGEAVQAAVESGATIVIDTDAHSTAEYANVRYGVHTARRGWAEPADVLNTWDPADVREFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSN3</accession>
    <name>R4VSN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445089.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00195">
        <property type="protein sequence ID" value="AGN00195"/>
        <property type="gene ID" value="L593_01210"/>
    </dbReference>
    <dbReference type="GeneID" id="16182704"/>
    <dbReference type="KEGG" id="sali:L593_01210"/>
    <dbReference type="eggNOG" id="arCOG03050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_19_0_2"/>
    <dbReference type="OrthoDB" id="110148at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="121" mass="13101" checksum="799A0FE991C9FE54" modified="2013-07-24" version="1">MHVLLGVEGSEESDRALESVLERAEEAGDELTVAVFALRDQSLDDVEESVRGRLAESDVPWEVERIEADHPASALVELAEAGPYEQLAIGGGQESPMGKIELGTTTEFVLLNAQVTVRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSV1</accession>
    <name>R4VSV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_01535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445154.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01535"/>
    <dbReference type="EnsemblBacteria" id="AGN00260">
        <property type="protein sequence ID" value="AGN00260"/>
        <property type="gene ID" value="L593_01535"/>
    </dbReference>
    <dbReference type="GeneID" id="16181968"/>
    <dbReference type="KEGG" id="sali:L593_01535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.312"/>
    <dbReference type="eggNOG" id="arCOG01709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="41486" checksum="71CE4C1CDA3EE49D" modified="2013-07-24" version="1">MNFSLPDEHRMMRDSVRDFCEAEIEPIAQEIENEHRFPAEIFEQLGQLDVMGMPIAEEYGGLGGDQLMYALVCEELGRVSGSVGLSYAANVSLGSKPIELFGTEAQKEEWLEPLATGEGMGAWALTEPGSGSDASDMNTTAEKDGDEYVIDGTKQFITNASEANSVLVKAVTDPDAGYDGISTFIVSPDDDGFSISNVWDKMGLNASPTCEIQLDSVRIPEDRLLGEEGEGWKQTMKTLQGGRISIAALSVGLAQGAFEAAKSYATEREQFDQPISKFDAVRDMIVAMHRKTHRARLLTHEAAWRYDQGERVVEESAMAKLDASEAAREVAEDAVQVLGGYGYTEDFAPQRFYRDAKLMEIGEGTSEIQHLVLGRELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT26</accession>
    <name>R4VT26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabD2</name>
        <name evidence="3" type="ORF">L593_01995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445244.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01995"/>
    <dbReference type="EnsemblBacteria" id="AGN00350">
        <property type="protein sequence ID" value="AGN00350"/>
        <property type="gene ID" value="L593_01995"/>
    </dbReference>
    <dbReference type="GeneID" id="16182527"/>
    <dbReference type="KEGG" id="sali:L593_01995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.405"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OrthoDB" id="56373at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="34"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="526" mass="56149" checksum="F4FF65A938144EB1" modified="2013-07-24" version="1">MSFETPDGYDGPVLERLAESVPVEPDVESAASDAELRVRAPFTDAVVGTVPACSPDAIRGAVDRARTAQADWKRRPASERVAAIERFEDLIHDHRAELLDLVQLESGKTRYDALEECGDVEFTAGHYAERTEAYLEPERHPGLVPGLTRVREHHDPYGVVGIVSPWNYPLTLAISDALPALLAGNAVVLKPAEQTPFTALYVEELLAEAGVPSAVFQVVPGRGETLGPPLIDAVDAVNFTGSTAVGREVAAQAAESLIPATLELGGKGPMIVREDAPLGRTVTGALRGAFASAGQLCIAVERIYVHESIADEFTDRLVERVRGLDLGTEFTYAPDVGSMVSADQLERVEAHVDDAVADGASLLTGGRRRPDVGPLVYEPTVLGEVPPGADVTCEETFGPVVTVTPVPDDETAIELANDTPYGLHGSVWTDDTAAGRRVARRLDCGTVCVNDAYMSMWGSTSAPMGGRKDSGLGRRHGDQGFEKYTRSQSVTVQHGHPLTPISAVPNRVTAWALAAYLRVVRGLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT30</accession>
    <name>R4VT30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00355">
        <property type="protein sequence ID" value="AGN00355"/>
        <property type="gene ID" value="L593_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02020"/>
    <dbReference type="eggNOG" id="arCOG10153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116315_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="PTHR35519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15417" checksum="CFA6BF2284CD2D19" modified="2013-07-24" version="1">MVPQSAADVTSDGEQAAQEAAVEIAVEAADGTITATPDEAAALRRTRVVSNLLDEAVRVPGTDYCVGLDPLLGVISGYGDAVSAAISLYPILEALRLDAPKRTLAKMLALVATDFAIGSIPVVGTVFDAVWKANAWNVRALERHIDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTK7</accession>
    <name>R4VTK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_03095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445464.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03095"/>
    <dbReference type="EnsemblBacteria" id="AGN00570">
        <property type="protein sequence ID" value="AGN00570"/>
        <property type="gene ID" value="L593_03095"/>
    </dbReference>
    <dbReference type="GeneID" id="16180456"/>
    <dbReference type="KEGG" id="sali:L593_03095"/>
    <dbReference type="eggNOG" id="arCOG04347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_7_3_2"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027034">
        <property type="entry name" value="OMS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF60">
        <property type="entry name" value="PTHR42912:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="23772" checksum="93F6037A397CE774" modified="2013-07-24" version="1">MSQDSAYSRSSTLGHVRDVYADQASTFARFAFLNRLLSGRYRRRAFESAEGAVLDVACGLGTNRGFVPNATEYTGIDVSPEMIEQAAKRHDDLERGEDLYEMDAQDLDFPDDSFDTVISSLSTCTFPDPHAALSEMHRVCRPDGQVLLLEHGRSSVWPIAKFQDWRAEAHFEKHACRWTQEPLEIVEDSPLTVESHWTALFGILTGVEARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTP3</accession>
    <name>R4VTP3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00605">
        <property type="protein sequence ID" value="AGN00605"/>
        <property type="gene ID" value="L593_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03270"/>
    <dbReference type="eggNOG" id="arCOG06388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134823_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="18801" checksum="F346C11003042E1C" modified="2013-07-24" version="1">MSVLTLASAMTFVVPFDGSDLAKAALVRAGAFATVLDEDVLAVTVIPKRNADYAANHGWIDPGSDYDLDTILDRLGSQVEACYPAATFRHELVDRYAPVGTIKNRLRRVIREVDASMVFVGSDNAGRMITALGSVGGGIATGDDYDVVIVRRAGPSKVPLIDDVSTELEDVEDLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV15</accession>
    <name>R4VV15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05680"/>
    <dbReference type="EnsemblBacteria" id="AGN01085">
        <property type="protein sequence ID" value="AGN01085"/>
        <property type="gene ID" value="L593_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1163"/>
    <dbReference type="eggNOG" id="arCOG00231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="43"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="302" mass="33752" checksum="A64CA069E56C4D3C" modified="2013-07-24" version="1">MTMSEADLTRTDDETHSATTAGETHERVQEEWRNYEFAGEPKFAVEDLDVYYGDERALQGVSMEIPEQSVTALIGPSGCGKSTYLRCLNRMNDRIKAAEIDGSVELDGQEIYQDNVDLVELRRRVGMVFQAPNPFPKSIRDNISYGPRKHGDISTGLLPKLLGRDDTEERDDLVERCLRQAALWDEVEDRLDDNALGLSGGQQQRLCIARCLAVDPEVILMDEPASALDPIATAKIEDLIEELAEDYTVVVVTHNMQQAARISDQTAVFLTGGELVEYGETDQVFEDPQSQRVEDYITGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVI9</accession>
    <name>R4VVI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01210">
        <property type="protein sequence ID" value="AGN01210"/>
        <property type="gene ID" value="L593_06315"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06315"/>
    <dbReference type="eggNOG" id="arCOG11822">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3371288_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="34" mass="3949" checksum="D71087673BFFB348" modified="2013-07-24" version="1">MSLEETVDYLAEELDIERSEHVREVGESVAELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVV8</accession>
    <name>R4VVV8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair protein Mre11</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mre11</name>
        <name evidence="8" type="ORF">L593_02225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Nuclease activity is regulated by Rad50.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445290.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02225"/>
    <dbReference type="EnsemblBacteria" id="AGN00396">
        <property type="protein sequence ID" value="AGN00396"/>
        <property type="gene ID" value="L593_02225"/>
    </dbReference>
    <dbReference type="GeneID" id="16180122"/>
    <dbReference type="KEGG" id="sali:L593_02225"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.451"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG11064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_3_0_2"/>
    <dbReference type="OrthoDB" id="25870at2157"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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        <property type="entry name" value="Mre11_archaea-type"/>
    </dbReference>
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        <property type="entry name" value="Mre11_N"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="105"/>
        </location>
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            <end position="491"/>
        </location>
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        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
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            <label>1</label>
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        <location>
            <position position="11"/>
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            <name>Mn(2+)</name>
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            <label>2</label>
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        <location>
            <position position="154"/>
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        <ligand>
            <name>Mn(2+)</name>
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            <name>Mn(2+)</name>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
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        <source>
            <dbReference type="EMBL" id="AGN00396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="491" mass="53041" checksum="CD51174C28BAEEF1" modified="2013-07-24" version="1">MTRVLHTGDTHVGYQQYHDPRRRRDFLRGFESVVEDAIADDVDAVVHAGDLFHDRRPDLQDLQGVVAALRELRAAGIPFLAIVGNHEAKRSGQWLDLFADLDLAERLDDEPRVVGEEGDDLALYGLDHVPESERDELGYEFDGHDAARSALVAHGLFGPFDPAEWDTEHVLDAATVDFDAMLLGDNHIPGKQQVGDTWVTYPGSTERASASERADRGYNVVTVDDGGLRITRRTLETREFVFVDVELADGEGAEVVRERVREHDHEDAVTIVTVEGEGEPIAPGPIEELASEQGAIVARVNDRRDVETAEDDDLEVSFADPDEAVRQRVREMGLSSAARDLDRVVRDGSIADSNVRGSARRRVAEHREAGLEAFEPVPEEDRPTSPVAEDGDESGSESVDDGAASESDTAPSAADTATQDVDSGRSSADPGTSTADPDMLADDPDTTDGPSTSSDDAGTTDDPGASPDGTSESSDDAPAEKESQASMEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVZ1</accession>
    <name>R4VVZ1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">L593_07165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01380.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_07165"/>
    <dbReference type="EnsemblBacteria" id="AGN01380">
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        <property type="gene ID" value="L593_07165"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_07165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1463"/>
    <dbReference type="eggNOG" id="arCOG00511">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="43"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="268" mass="29880" checksum="125DC9A3C7DDD3DD" modified="2013-07-24" version="1">MVDATIRGIHRGTIHSDVNFHLEAETVATVEEPSPGAERIATPVYNLVIEHPEATILWDTGSHPEAGDGHWPEATYQAFEHRDAAEHELAEDLADAGYALEDVDAVVCSHLHVDHAGGLHTFAGTDTPIYVHEQELQFAYYSACTPGGDGGGYVRADFDHDLHWRIVHRDRTSFFEDVEFVRLPGHSPGLLGMLVHLDDHGSLLFGSDVAELEANYEQERPLGAGLLRDRQAWQESIGLLQDIERRHDADVIYGHDPDQHERVLDGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW33</accession>
    <name>R4VW33_9EURY</name>
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        <submittedName>
            <fullName evidence="7">2-oxoglutarate ferredoxin oxidoreductase subunit beta</fullName>
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        <name evidence="7" type="ORF">L593_02625</name>
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    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02625"/>
    <dbReference type="EnsemblBacteria" id="AGN00476">
        <property type="protein sequence ID" value="AGN00476"/>
        <property type="gene ID" value="L593_02625"/>
    </dbReference>
    <dbReference type="GeneID" id="16180420"/>
    <dbReference type="KEGG" id="sali:L593_02625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.532"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="6">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="287" mass="31061" checksum="98F352FA59098E22" modified="2013-07-24" version="1">MSSDVRFTDFKSDKQPTWCPGCGDFGTMNGMMKALANTGNDPDNTFVVAGIGCSGKIGTYMHSYALHGVHGRALPVGSGVKIANPDLEVMVAGGDGDGYSIGAGHFVHAVRRNVDMTYVVMDNRIYGLTKGQASPTSREDFETSTSPEGPKQPPVNPLALAHAAGATFIAQSFSSDAQRHTEIVQQAIEHDGFGFVNVFSPCVTFNDVDTYDYFRDSLVDLAETDHDPTDEQEAKEVIMDGETEHMGVIYQDEESVPFSELHGLDSNMAEIPDGAPEDAMDLVREFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW55</accession>
    <name>R4VW55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445395.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02750"/>
    <dbReference type="EnsemblBacteria" id="AGN00501">
        <property type="protein sequence ID" value="AGN00501"/>
        <property type="gene ID" value="L593_02750"/>
    </dbReference>
    <dbReference type="GeneID" id="16180322"/>
    <dbReference type="KEGG" id="sali:L593_02750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.557"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003088_0_0_2"/>
    <dbReference type="OrthoDB" id="5636at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="276"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="677"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="846" mass="88383" checksum="2FB5D476C2EABA29" modified="2013-07-24" version="1">MIRRYAAATTDFVTTHSRIVLLLTLLLTAGMAAGTTHLSMGGEGGGIGAAVDTHVDDRAQYIEEEYGASDSGDDGVARTAVYVRSADGNALSKEHLLATLRFQRTVLEADAVDAALRERPAGSAGPRDGASSIASMVGTRAADESDPTIEEQIAALEATDATTVTTIVDETIAENERARRLLPDSYESGTATAESHQVVFGFDEAADGRPPSDATAALHDAASGRTDPTVFTVGEHALAASQGVFVENTMTLIVPVVLALILGVAAFTYRDPVDVLLGIVGVVVSILWMFGLLGWAGVAAGPAAVIGPVLVAGLSIDYGFHVFMRYREERNADESVRPAMGRGLRSVAPALALVTITAAIGFLATVATPVGMLRDLGIGITVGVVAAFGVFLTLIPALTVEVDALVEGAGFDRHRRPLGQGRYVRSTLAGAVTLARRGAPVVLVVAIVLATAGGLAWATLDQASVQQQSEPAAEWKQDLPGPMGWEENDLISRQAYVADQFRTTEEGDRMQMLIEGDVTDDGTLDAIDAGLRTAERRGAIPSQRAANVRSPLTVIRSVAERSEAFGATVAAADADGDGVPDRNLDAVYDHLYRIEPESASQVIERSDGRYESLRVVGPPEAAAGTAVPDDRATDLRAVEDRIETEQDGLTATVVSDATAQRATLETITDGILRTMVLALVAVFGVLVATFRLVHGSGTLGAVTAGPIVLVLGFVVGGMALLDVPLTFLTALLVSLLIGIGVDHNIHVGDRFAQELDRGNGPVQALHRAVIGTGGALLGSTLTTVAAFAALVLHPNPQFESFATLVILALLAALATSMLVLPSALLVWWRYGCGEWTASKDPEPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWB7</accession>
    <name>R4VWB7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase</fullName>
            <ecNumber evidence="2">2.6.1.118</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysJ</name>
        <name evidence="4" type="ORF">L593_07900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:41952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="2.6.1.118"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:52672"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.118" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446419.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07900"/>
    <dbReference type="EnsemblBacteria" id="AGN01525">
        <property type="protein sequence ID" value="AGN01525"/>
        <property type="gene ID" value="L593_07900"/>
    </dbReference>
    <dbReference type="GeneID" id="16181987"/>
    <dbReference type="KEGG" id="sali:L593_07900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1618"/>
    <dbReference type="eggNOG" id="arCOG00914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00038"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02084">
        <property type="entry name" value="LysJ_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037537">
        <property type="entry name" value="LysJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="382" mass="39984" checksum="618CD9D89CB8B99C" modified="2013-07-24" version="1">MGNAGFVFSEKPIRIERGEGPYLYDDNGNEFLDFGASYACTPTGHCHPEVVDAVVEQAKQLLYVQGSYPVDARDALYDRLAAIAPGDLENVWLCNSGTEANEAALKFARAATGDSKLVATKQAFHGRTMGALATTWKGKYKAPYEPLIGGVDHVDYGDADQLADAVDGDTAAIILEPVQGEGGVHPATAEYLQAARDVADDNGAALVIDEIQTGLGRTGSLWACERADVVPDALTTAKGLASGLPMGATLVADWLAEEHGDHGSTFSGGPTVSAAAEATLDVIVEENLPRNAAEVGGYLREEIEAGIESGEIDARGVRGQGLMLGIEVKRGANRLLKELALDHGILALPAGRTVLRLLPPLTIDESHADEVVAAIADVTGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX13</accession>
    <name>R4VX13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.117</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapD</name>
        <name evidence="3" type="ORF">L593_09050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.117" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
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        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="31436" checksum="6D2F0C124C55CC81" modified="2013-07-24" version="1">MSLQSDVEALWARYQDGAVDAASASADDLAVLEAFLESLEAGELRAAEPVEPADPDAVGGDGEPEVASATAEWEAVEWVKQGVLLNFGLRENVAHEYGDVTYTDVLPLRRTDDLAERGSRNTPDGTVLRRGCYLGSDCIMMSPSFVNIGAYVGDGTLIDSCDTVGSAAQIGANVKLGANTLIGGVLEPVEDAPVVIEDGVSLGAGCRVTSGFVVGHDSIVGENTLLTPRIPVYDLVDGEVHYGKLPPERRAFQRFVESSVSDEELIPGSAYKPAVVATHVEEETLEATEREDVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXM4</accession>
    <name>R4VXM4_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080903_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="224" mass="24253" checksum="D84BF176CE33A33B" modified="2013-07-24" version="1">MKGEGVTTLETVGEFEGGASWIAYPDEQMQRASHVLVEDEELWLVDPVDADDLDQWLAELGTVAGIVLLLDRHKRDAAEIARRHDVAVHLPEQLAAEGATLDAPFETFEGRLADTGYRTIEVLDRFFWHEVALFDPDSATLVVPEALGTAEYFCTASERLGVHPALRMFPPRGALGSIDPDRILVGHGAPVLEDASEALGTALSNSRSGAPGLYARTVRAALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXM7</accession>
    <name>R4VXM7_9EURY</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036680_0_0_2"/>
    <dbReference type="OrthoDB" id="44140at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="260" mass="28917" checksum="7D79E129533AD208" modified="2013-07-24" version="1">MKPSRGDGSSVSRSRIDPHVKVLDESLVERATRRGLDVVVYAPHFTRLPEIERRARELSTEDLLVVPAREVFTGTYRNRKHVLALGLQEPVPDFISLDAAMAEFERQDATVLAPHPEYLTVGLTNADVRTYVEQIDAIEVYNPKYLPGDAGRSRSLAGEFDLPAFGSSYAHLGWTIGDVWTETNRTVDDADAVASAFAADGNRVSRRSGVGPRLRSISEIGHLAWENTWKKIDRIGFPGMEATHPNDDAYGGRFDEAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXS7</accession>
    <name>R4VXS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_10625</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02070">
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        <property type="gene ID" value="L593_10625"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10625"/>
    <dbReference type="eggNOG" id="arCOG09141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099717_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="23354" checksum="332E773FC7F825BC" modified="2013-07-24" version="1">MLAVLRSRALLLVVCAAIGVGMAFAGTSVGATGALTTDSTGPKFVVSDENVTFRHAGGHETVVQNVSDLERIEFEQAEDGTFQINTERVQPFTAAERETAVAVARDNASVQQAMAELGDYEFSVEPIRKLTVNENFSINATPTDEHEDAMTGNATSETFVIESDQEGTVTVDREPEYVEDEAVVRIADENDDTQYSVVVDLEEEIVVDGIDWESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY50</accession>
    <name>R4VY50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446075.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06160"/>
    <dbReference type="EnsemblBacteria" id="AGN01181">
        <property type="protein sequence ID" value="AGN01181"/>
        <property type="gene ID" value="L593_06160"/>
    </dbReference>
    <dbReference type="GeneID" id="16181708"/>
    <dbReference type="KEGG" id="sali:L593_06160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1258"/>
    <dbReference type="eggNOG" id="arCOG04695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119850_0_0_2"/>
    <dbReference type="OrthoDB" id="103396at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043832">
        <property type="entry name" value="DUF5809"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19125">
        <property type="entry name" value="DUF5809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="137" mass="15296" checksum="B15212A86F31C225" modified="2013-07-24" version="1">METIGRLTPTDPEDARAAYEELATPASVVTKEVARALDVEDIQERVSPEVIVTARDAIFASTLAVTVGTREEFEAWRDEFDGEVFEAGNENVDSVVWHAFDGEGVAATFHEERDAAVATLRRQAFNRLYRDLFYPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYA9</accession>
    <name>R4VYA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01206">
        <property type="protein sequence ID" value="AGN01206"/>
        <property type="gene ID" value="L593_06285"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06285"/>
    <dbReference type="eggNOG" id="arCOG01250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045500_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="41133" checksum="F11BE17F1061D2B8" modified="2013-07-24" version="1">MGMSQDALEPIEPERAIELYLEDRSDELRTATQRAHRSALGIFEEWAAEYGLTNLNDLSGRDLIAFKNWRKKETDISTVTLNGALGILKRFFRFCEIIEAVEPDFHERVPLPNVPPDAEVKDDAPEDEAVEAIRSYYQQFEYASRRHTQFELIAEIGVRLGTAIAIDLDDIQWDREAIQIRHRPMESEGETPLKNGAGGERIVNLSPSFTGLLEDYVQHNRHDVEDDVGREPLFTTSKGRASTTTIRRDFYKLTRPCEYSNDCPHDRDISDCEATAPVQATTCPSSFTTHPLRKWSIMQQLNDGVPKEILSDRVDVSVPILDKHYDQRSEERKSQRRREVLESNHRQYHMTDGGSREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYB8</accession>
    <name>R4VYB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447144.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11535"/>
    <dbReference type="EnsemblBacteria" id="AGN02250">
        <property type="protein sequence ID" value="AGN02250"/>
        <property type="gene ID" value="L593_11535"/>
    </dbReference>
    <dbReference type="GeneID" id="16182829"/>
    <dbReference type="KEGG" id="sali:L593_11535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2378"/>
    <dbReference type="eggNOG" id="arCOG04704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079334_1_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="284" mass="31552" checksum="D9CD401ACBF005A5" modified="2013-07-24" version="1">MNVLITGAHGTVGTAITNHLEHDDRFEFTLLDVAEPDGVYDGEPPGEVVTADVTDYDDIRPHFDGQDAVVHLALIPGTGGAGSREIPWNQAQTDNLEALHNVAKAAEDANVDSFLFASSNHAVGLVEVTNQPEVYHDQGIVAGHDEPHRPDSRYGLTKSYGEDLGRFLAEVHDVSFYGLRIGAVRDPAYDHPFGDAERGVDEGRWERGSEDYDEMVARMKGLWQSRRDIAQLVECCLVDDSVEWDHFYGVSANERRWLDDLEYAKETIGYEPADEGEEWDAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYJ3</accession>
    <name>R4VYJ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="3">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">panB</name>
        <name evidence="7" type="ORF">L593_11935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11935"/>
    <dbReference type="EnsemblBacteria" id="AGN02330">
        <property type="protein sequence ID" value="AGN02330"/>
        <property type="gene ID" value="L593_11935"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2456"/>
    <dbReference type="eggNOG" id="arCOG00584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="3 5">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5 6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="29157" checksum="543844A98BE1E391" modified="2013-07-24" version="1">MSRTTIRDLQTRYESGEPITMLTAYDAPIARQVDRGGVDAILVGDSAGDNHMGYDDTLPVTLEEALSNTAAVDRAVDDALVIGDMPFLSYGTSIAESVENAGRFMKEAGADAVKLETAPYGETTIEIVDRCTELGIPVQGHIGYTPQRNNEIGGAFVQGKDRDVSAGMQALVDTAEELVAAGAFSIVLETVSEAAAKAVTEAVDVPTIGIGAGRYVDGQVLVTNDVIGLSGESFKLSKQYADLDSKIRSAVEAYVADVESGEFPTGEHAFEPIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYP1</accession>
    <name>R4VYP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447274.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02380">
        <property type="protein sequence ID" value="AGN02380"/>
        <property type="gene ID" value="L593_12185"/>
    </dbReference>
    <dbReference type="GeneID" id="16180239"/>
    <dbReference type="KEGG" id="sali:L593_12185"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2507"/>
    <dbReference type="eggNOG" id="arCOG00381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048695_1_0_2"/>
    <dbReference type="OrthoDB" id="50724at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="422" mass="45537" checksum="6E75FC5BD1F04DAA" modified="2013-07-24" version="1">MDRPEWILVLAILSVGLVGATVPAAAGIVDADSGVGGAVESIGSTHTAISQEEQAVGTSTLLAPLRWLPQQRDQFLATAQQQFERSTFRVRVRSDGDARWVFRYERPIETDDERSAFERYADRFRTEETDLYREFQNRSASLTAHASELTGRPMTARNVSRDAGIAQTPTQEEGYVELAFEWTNFGRVSGEEVVVGDVFEGGLYLGETQSLIFVAGEGVEFTSVHPDGSPSNATLADSRSVTWTGEHQFADRHPRAVFQIPQPVASGSGDDGASMLWLLGGGVIGLLLVTLLAITRYGGIPRREESTASAAAEAPATPTEADTVEEGAEDAAPSATADPAAVPEEPISDDRRVQQLLEDGGGRMKQTAIVEETDWSKSKVSMLLSEMEEDGRIKKIQVGRENIIALAGHEPEAASSPFDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ59</accession>
    <name>R4VZ59_9EURY</name>
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            <fullName evidence="3">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_07955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446430.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07955"/>
    <dbReference type="EnsemblBacteria" id="AGN01536">
        <property type="protein sequence ID" value="AGN01536"/>
        <property type="gene ID" value="L593_07955"/>
    </dbReference>
    <dbReference type="GeneID" id="16182275"/>
    <dbReference type="KEGG" id="sali:L593_07955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1630"/>
    <dbReference type="eggNOG" id="arCOG03015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_5_2"/>
    <dbReference type="OrthoDB" id="84415at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="36091" checksum="C34ADC248286BDD0" modified="2013-07-24" version="1">MHVLLTGATGFVGRHLLPELRDRGHQVTALVRDRSAVTLPDDVRVIEGDLQEPAAMTVFEPAPEATAGGDDVAAASDAAGEPGATETTFADAIAGCDAAYYLIHSMRAGEDFEALDRDLAQGFADAASAAGIERVIYLGGLGEGTGSASGDGDADARGRTLEDLSPHLRSRREVEAILAEGDYELTTLRAAIIIGKGSAGFEIVRQLSTKLPVMVTPSWVRTPCQPIAIADAVAYLAGVLDAPETAGGTYGIGGPEVLPYEEMLRRVGRILGGGPIIVPVPVLSPKLSSYWVGLVTDVDASIARPLIEGLRTPVVVEDPAIDEYVDVEKTPFDEAVRRALAEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ83</accession>
    <name>R4VZ83_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_08080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446455.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08080"/>
    <dbReference type="EnsemblBacteria" id="AGN01561">
        <property type="protein sequence ID" value="AGN01561"/>
        <property type="gene ID" value="L593_08080"/>
    </dbReference>
    <dbReference type="GeneID" id="16182301"/>
    <dbReference type="KEGG" id="sali:L593_08080"/>
    <dbReference type="eggNOG" id="arCOG06450">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387561_0_0_2"/>
    <dbReference type="OrthoDB" id="65040at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="22089" checksum="01F23721D193CFF7" modified="2013-07-24" version="1">MSHFAYPCPDCRSNTDLHDPDCSFGGRSRSEIERAYADVLAVLSTGPRPATELRRSAPGEWTPLHDGALDRLRREHRVREDGDALELLTPEERTEAISTPTHEPLRTVYEQGSVPGCHDNAVFAMIAYYEMVGLSWDETKERVVEWLEESGAWARGGFEEDSPATLVEDKRHVYEQGYGWKEKATAAKRVIERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZE9</accession>
    <name>R4VZE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446525.1">
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08430"/>
    <dbReference type="EnsemblBacteria" id="AGN01631">
        <property type="protein sequence ID" value="AGN01631"/>
        <property type="gene ID" value="L593_08430"/>
    </dbReference>
    <dbReference type="GeneID" id="16180072"/>
    <dbReference type="KEGG" id="sali:L593_08430"/>
    <dbReference type="eggNOG" id="arCOG10707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044471_0_0_2"/>
    <dbReference type="OrthoDB" id="98132at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="14126" checksum="4D8B80161E453666" modified="2013-07-24" version="1">MIEEALPADWERERRPGGVDTDRRPSFVAFRHSSGDVRVRIAPPNPELDRHAHLLTVTLYPGTELATTSEVRSVTSEDRVADLAVDWMKLFDGAYDGPGDVERAAQFAIERIAPPDVVLDSLVNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZN6</accession>
    <name>R4VZN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447599.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02705">
        <property type="protein sequence ID" value="AGN02705"/>
        <property type="gene ID" value="L593_13830"/>
    </dbReference>
    <dbReference type="GeneID" id="16180868"/>
    <dbReference type="KEGG" id="sali:L593_13830"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091367_0_0_2"/>
    <dbReference type="OrthoDB" id="128933at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="124" mass="12411" checksum="F80076E00998676C" modified="2013-07-24" version="1">MASGATSSILVLVVSILIGGLAIHVGAAFALASKDYGHAVVTAVLGAFAWAVVNYLFTAVGLSPGLSSFVALVVWVGVIGWRYETGWLRAGLIGAFAWVAAIVALVVLNLLGVGGIGAYGIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZP7</accession>
    <name>R4VZP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446590.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08755"/>
    <dbReference type="EnsemblBacteria" id="AGN01696">
        <property type="protein sequence ID" value="AGN01696"/>
        <property type="gene ID" value="L593_08755"/>
    </dbReference>
    <dbReference type="GeneID" id="16182478"/>
    <dbReference type="KEGG" id="sali:L593_08755"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_5_2"/>
    <dbReference type="OrthoDB" id="101975at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="17063" checksum="5116D97C529AFF05" modified="2013-07-24" version="1">MATARSIREDELAELLELYEMLSSRNESLDSSDPELREEFDRMRTDDSLTIVAVEHDDHLVATCTVSVTRNLTRDGRPWAVMENVVTHEDYRGEGFGTAAVEYGFDVAEQAGCYKVMLLTGRESESVLGFYEDCGFDPDEKRGFVRYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W045</accession>
    <name>R4W045_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09530"/>
    <dbReference type="EnsemblBacteria" id="AGN01851">
        <property type="protein sequence ID" value="AGN01851"/>
        <property type="gene ID" value="L593_09530"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1962"/>
    <dbReference type="eggNOG" id="arCOG00895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="264" mass="28410" checksum="0E3165D4615172F9" modified="2013-07-24" version="1">MGGREGTVMSEVAQPDGNGARDGESAEAANDATDAATDGEYTFDDLAVVMGTYNEEEAIATVLQDVEEVTDGKAEVVCVDGSSDRTPEIAREHGATVIGQEPQGYGVAVSAAIQAPDRPIVVTTDCDDTYPMEELPVFLEEINDGADVVSGDRISPGADAMPGFNRFGNQVFAAVASVLMLRRVHDTTTGMRAYRKEVIDAIEWTENTGLSAELLIRPLMRGYDVRERPIPYRERAGETKLDPIQGGAAILKSILKVCVQERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W047</accession>
    <name>R4W047_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447779.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14755"/>
    <dbReference type="EnsemblBacteria" id="AGN02885">
        <property type="protein sequence ID" value="AGN02885"/>
        <property type="gene ID" value="L593_14755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181450"/>
    <dbReference type="KEGG" id="sali:L593_14755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3013"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OrthoDB" id="47519at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="34498" checksum="3525B0730A23C66B" modified="2013-07-24" version="1">MTTHGEPLDSVLDTVGETPLVAVHAAPDDVPIYAKLESFNPGASVKDRIGKYMLEAMLERGDVAPGGTVVEPTAGNTGIGFAVAAGELELDAVFVVPERFSVEKQQLMDALGATVVNTPTEDGMQGAIDRAHQLAEELEDAVVPQQFSNPLNAQAHAATTGPEIMQALDEEVGAIVAGCGTGGTLMGITKAVREEIPDVHVVAVEPEGSTFGELFGRDPDEDEYKTEGIGTHDVATNDLFEPDLVDDLLTIDDRSIHAEMRRLATEEGHLVASSAAANSLAAQHVAEGIADGTIDAPYDTVVTVFPDSSERYLSKGVYRSFEEWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0L4</accession>
    <name>R4W0L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446970.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10655"/>
    <dbReference type="EnsemblBacteria" id="AGN02076">
        <property type="protein sequence ID" value="AGN02076"/>
        <property type="gene ID" value="L593_10655"/>
    </dbReference>
    <dbReference type="GeneID" id="16180757"/>
    <dbReference type="KEGG" id="sali:L593_10655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2197"/>
    <dbReference type="eggNOG" id="arCOG04199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_2"/>
    <dbReference type="OrthoDB" id="6295at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="675" mass="74676" checksum="1D660C82045BEDF2" modified="2013-07-24" version="1">MNWREAESTYEGPGVGESTIPELFEETAERNAHRPAQRYKGGVYDRTITETVLPAASPGEFRSISYDEMRDIVHHLAAGFRDLGVDAGKRVAIFAHTRMEWAQSDFGVLAAGGVVTTVYPESSEGKVSYLLSDPDATGVVLEGDEHLEHVLAVQDDLDLEFVVQMDRPGSGNASDDFDAAAVHDERDDVLTLAEVHDRGAELYHPEEYEEWVAERDLDDLCSLIYTSGTTGKPKGVQLTHWNFRSNVNQVLSRYGDRPDKDVPALDAETRTVSYLPLAHVFERLAGHFVIFAAGGSVAYAESPDTLQEDFGLVQPTSATSVPRVYEKIYDAIREQAASSERREQIFEWAVDVGQQYHEADSPGVVLRAKRAIADRLVFSKVRDALGGEIDFLLSGGGSLSAELCSLYHGMGLPILEGYGLTETAPVITVNPPEEPKVGTIGPPVIDEDVWVDESMVPEGQFPEDEGTVGELLVRGPNVTDGYWNKPEETEEAFLDELPEGATEGPGQDWNQSGKWFRTGDIVHQRPDGYVEFRERAKQLLVLSTGKNVAPGPIEDGFAASEVVEQCMVVGDGRKFVGALIVPNFEAVRSWADSEGIELPEDDGAVAAHPAVRERIQEEVDRVNEPFEEYETIKRFAIATEEFTEENDLLTPTMKKKRRTILSRYEESVESLYEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0M0</accession>
    <name>R4W0M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446980.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10705"/>
    <dbReference type="EnsemblBacteria" id="AGN02086">
        <property type="protein sequence ID" value="AGN02086"/>
        <property type="gene ID" value="L593_10705"/>
    </dbReference>
    <dbReference type="GeneID" id="16181391"/>
    <dbReference type="KEGG" id="sali:L593_10705"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2207"/>
    <dbReference type="eggNOG" id="arCOG03730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368283_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="756" mass="76075" checksum="336427D01D47AB80" modified="2013-07-24" version="1">MTRSPNRPTDTYLDVLRTLGVTDAALGRHHDADAEVPVRLAIDRDRGSPTADLLDALAATGRMLDLRDGLDAADDAGLGDALARFGFRVDLADPDADGGGEEVVLTVADAVTGATDRVDTAQDGDAAERTLRSALLDPAGIELRALLDGRHLVAEKRELATLAERYGPRIEPFDDPLLTPEAAIDRDEFEHAIADRTEESHIGDSVDPPTEPANPDAITEPGNADAISWTNPTDADGPASEAVDAALADSGPRTHTIEDDGLDDAPAVGGGPKRTVSTSGIDGVFDKLESGTTDDAPAHTAMSDSIDADTDAATDEDESSTDPVETPQGLTGGPTRTVSSTSADDILQRATGSDDFDSIAAEEGEADPDAVLADADGVPEAIEDEVETGSGDDGADERAEDAERPQHAEAESDSETERGGATPPTVDPAAPEPAIPADDEHPTGPQTRRVEDIGAAETSETEEDDEQDAARDGGSEPVAEGSGDGDLPVVSTSRRSASDAAHDDRRDAGGAEGASGGTDRGAPTDDAESPSLGDRGNAEDATASDEPSSAADASPSIDATESPEASGAADASPSIDATESPEASGAADASASSDTTESADVSGASDGNESADAGATSEASRSSDDHTAGAPERGDGIGADLHGDDVELRCGTQTVDRGSDPAPDLSAVEAEDGTGASADGPLAGAGGLRPDDGPLAGAGGLRPDDGPQADASDDAAPSDATAAPASDGDQSAAENAESTESGQGLVSRIASRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0R5</accession>
    <name>R4W0R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447040.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11005"/>
    <dbReference type="EnsemblBacteria" id="AGN02146">
        <property type="protein sequence ID" value="AGN02146"/>
        <property type="gene ID" value="L593_11005"/>
    </dbReference>
    <dbReference type="GeneID" id="16182544"/>
    <dbReference type="KEGG" id="sali:L593_11005"/>
    <dbReference type="eggNOG" id="arCOG04404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010031_0_0_2"/>
    <dbReference type="OrthoDB" id="111776at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="134" mass="14651" checksum="E07CEA9DB9348BE1" modified="2013-07-24" version="1">MSIDAEEAGEANADADVEALGRELGEAITELPAYERYEAAKADVENHEEAQERIAEVEQLREEFMLARQIGEASQADLQTLQSAQESLHELPVMEEYLEAQADLTGHLETINEAISEPLADLDFGEEAGGCCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0S5</accession>
    <name>R4W0S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447050.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11055"/>
    <dbReference type="EnsemblBacteria" id="AGN02156">
        <property type="protein sequence ID" value="AGN02156"/>
        <property type="gene ID" value="L593_11055"/>
    </dbReference>
    <dbReference type="GeneID" id="16180797"/>
    <dbReference type="KEGG" id="sali:L593_11055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2281"/>
    <dbReference type="eggNOG" id="arCOG00005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151709_0_0_2"/>
    <dbReference type="OrthoDB" id="124778at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="91" mass="10925" checksum="17824D2B894D8D72" modified="2013-07-24" version="1">MYDLTGFQRDLLYTIAGKEEPHGLAIKDELEDYYEKEIHHGRLYPNLDTLVDKGLVEKGQLDRRTNYYMLTSRGKREIEARREWEDQYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1E3</accession>
    <name>R4W1E3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12385"/>
    <dbReference type="EnsemblBacteria" id="AGN02416">
        <property type="protein sequence ID" value="AGN02416"/>
        <property type="gene ID" value="L593_12385"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12385"/>
    <dbReference type="HOGENOM" id="CLU_736969_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spondin" evidence="2">
        <location>
            <begin position="94"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="37911" checksum="A23BDC87426A96EB" modified="2013-07-24" version="1">MHDQMTPHNDSPTDEPRDAESTDGGKFTRRQTLAIGGAAIGASAMGAGSVFAQDDGGNETATGNETDQGDDAPPGGGGSTFRFTITNLTGGQAFTPPAVATHSPSTELFSVGEPANEVVQELAENGNLEPLAVAVQEDTDISGVGLGEAPLVPSDDPGDTGHPYYVTLEVDADQDATHMTFISMLIATNDGFVGLDTVELPTEVNGSKTLYPGSYDAGTEENTETWDDLVPAGRELIGGQTPTGGTTETDEELAEDGVIHPHPGTMGEGDLDPEVYGWEDPAAVVHVEKIDGPDDVQLDDGEGDGNVTDGDGNATDGDGNVTDGEGNVTDGDGNVTDGDGNVTGDGGNATDGAGNATDGNATDGNATNGGNDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W230</accession>
    <name>R4W230_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thrB</name>
        <name evidence="8" type="ORF">L593_13785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447590.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13785"/>
    <dbReference type="EnsemblBacteria" id="AGN02696">
        <property type="protein sequence ID" value="AGN02696"/>
        <property type="gene ID" value="L593_13785"/>
    </dbReference>
    <dbReference type="GeneID" id="16180828"/>
    <dbReference type="KEGG" id="sali:L593_13785"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2820"/>
    <dbReference type="eggNOG" id="arCOG01027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_2"/>
    <dbReference type="OrthoDB" id="91752at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="202"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="29527" checksum="0129E0FDA4F428D7" modified="2013-07-24" version="1">MITVRAPATSANLGSGFDVFGVALGRPADVVQVEKADETSIEVTGVGSRFIPEDPEGNTVGAVAKALDAPAHIRIDKGVRPASGLGSSAASAAGAALALNELYDRGYSRSELVPIAAEGEELVSGEAHEDNVAPALMGGFTVAAGGDVGVTAVDAGIPLVVCLPEVVVSTRDARGVLPDTASLEELVDTVGRAATLTLGMARDDPELVGAGMHDEVVTPARAKLIDGYDDVRDAALEAGATGVTVSGAGPGVIAACYPGRRRAIASAMVEAFDQRGVECRAYQTAVGLGATIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W276</accession>
    <name>R4W276_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase MptA</fullName>
            <ecNumber evidence="3">3.5.4.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP cyclohydrolase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mptA</name>
        <name evidence="4" type="ORF">L593_14035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58854"/>
            <dbReference type="EC" id="3.5.4.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.39" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447640.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14035"/>
    <dbReference type="EnsemblBacteria" id="AGN02746">
        <property type="protein sequence ID" value="AGN02746"/>
        <property type="gene ID" value="L593_14035"/>
    </dbReference>
    <dbReference type="GeneID" id="16181026"/>
    <dbReference type="KEGG" id="sali:L593_14035"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2872"/>
    <dbReference type="eggNOG" id="arCOG04301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_0_2"/>
    <dbReference type="OrthoDB" id="109805at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_A">
        <property type="entry name" value="GTP_cyclohydrol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022840">
        <property type="entry name" value="GTP_cyclohydrolase_MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00294">
        <property type="entry name" value="TIGR00294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="May be catalytically important" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="34187" checksum="6D3B44D895F1F2FC" modified="2013-07-24" version="1">MSQQLPDVQADRPDVQVGLNRVGVTGVEKLVKIARPDDRPIVLMAEFEVFVDLPSWRKGADMSRNMEVVDETLEAATRDEVYGIENVCTEAARRLLEKHDYTSKAEVSMEAEFVQREDTPASERETQFVSDVLARATASDEGVRTEIGAEVTGMTVCPCSQGMSEARARETLEDLDVDDDTVEAFLDEVPQPGHSQRGHATLTVESDGVPEVDLVDLIDVARDSMSARIYNLAKRPDEDHMTFDAHSDAKFVEDCVRSMAEGVVRTFPDLPDDAVVTMRQSNDESIHQHNAHAERVVDVATLRSEVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2R2</accession>
    <name>R4W2R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monovalent cation/proton antiporter, MnhG/PhaG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00710"/>
    <dbReference type="EnsemblBacteria" id="AGN00097">
        <property type="protein sequence ID" value="AGN00097"/>
        <property type="gene ID" value="L593_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.144"/>
    <dbReference type="eggNOG" id="arCOG03082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_6_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="12990" checksum="70799AEE3B8B37A4" modified="2013-07-24" version="1">MEELRAIAIVALVLVGLFFTVVSTVGVLRLPDVYSRAHTASQADTLGAGFALAGVALAIGVDATAIKTVLLLFFIFVTNPTAAHAIARAAHEEGIEPWTTGDGADGATAPPSTDGDRSTIEEGGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V1</accession>
    <name>R4W2V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445061.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01070"/>
    <dbReference type="EnsemblBacteria" id="AGN00167">
        <property type="protein sequence ID" value="AGN00167"/>
        <property type="gene ID" value="L593_01070"/>
    </dbReference>
    <dbReference type="GeneID" id="16182370"/>
    <dbReference type="KEGG" id="sali:L593_01070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.219"/>
    <dbReference type="eggNOG" id="arCOG01270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_2"/>
    <dbReference type="OrthoDB" id="66651at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="302" mass="31633" checksum="B63F12C0668A90D7" modified="2013-07-24" version="1">MFSGLPTVLVNAALISALYALIAIGFTMIFGVGGVLNLAHGALLMAGAYAYLLLARDTISVPVFESMTLHPLIAFPIAVVTVAVLSYLLYVVIVQFVEDNPIVTFLATIVVALAATEVVIHYAGASTHTYTLIPSDLLPSTVGFGPVDGILTVDVVGFVVSWVAIGLLWLYVTKTDSGRAIRATSMTERGARLTGVNVHAVRARTWLVAGALAGIGGVFLGASASATPGMWLQPLSLAFIIVVIGGIGSIKGSIVAAYLIGFLQTGVGEYLGQNFRGILSLVLLIAVLFMLPQGLFGREFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W398</accession>
    <name>R4W398_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_02230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445291.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02230"/>
    <dbReference type="EnsemblBacteria" id="AGN00397">
        <property type="protein sequence ID" value="AGN00397"/>
        <property type="gene ID" value="L593_02230"/>
    </dbReference>
    <dbReference type="GeneID" id="16180137"/>
    <dbReference type="KEGG" id="sali:L593_02230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.452"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="256"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="383"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="457" mass="48371" checksum="42669BA4C5FC9403" modified="2013-07-24" version="1">MDEISFGTDGWRAHSDLVTPERLHAIAQSVVDLLAEDGLDGEQIVIGYDARDGARERAEEIARVLAAGGHDVLLADRDCPTPAVALAIVQRDAAGGFVVTASHNPPEYSGVKFIPHDGAPALPAVTERIEAGLREPEPSNEGAQGEIREVDLIESQIGAVLDLLAPDLDGLTVAYDAIHGSGRGVTDDALERAGADVFRLRCTRDPTFGGGEPNPEPEMLEELAEMVEAGEVDLGIANDGDADRVAIVTEAGFLDANELLAALYEFLLQSDTGPAVRTVSTSSLIDRIAEDHDEAIAETPVGFKWVAQAMAEDDALIGGEESGGLSIRGHVREKDGTLAAVLAAAAHAEEPLQDRIERLRSAYGNLRQDRVSVVCPDDRKEPVMAALEDELPDAVAGAAVESVNPADGVKCMLADGTWVLVRPSGTEPKLRIYAEAESDDRIDGLLAAGREIVEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3U9</accession>
    <name>R4W3U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445626.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03905"/>
    <dbReference type="EnsemblBacteria" id="AGN00732">
        <property type="protein sequence ID" value="AGN00732"/>
        <property type="gene ID" value="L593_03905"/>
    </dbReference>
    <dbReference type="GeneID" id="16180711"/>
    <dbReference type="KEGG" id="sali:L593_03905"/>
    <dbReference type="eggNOG" id="arCOG04755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="23462" checksum="F7F5867186174BFE" modified="2013-07-24" version="1">MWSSIKRDAASGLIVLTPLFATIYTLWWVFNFVAGVPLMGTIAQRITVLHVLDPAVARVLLTIGVLLGSLLLASWLMRTKLGPFLDDRIEASVNTLPGFRVVYNASKIAIETVVDEDVDLNSPAKVELWNDARMTAFPTGREADDGRTTVYVPASPVIFVGWVIELEESRVIPADESVEDALIRVISAGFADRSEPPSEAKARSLEASGESRHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Z2</accession>
    <name>R4W3Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445706.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04305"/>
    <dbReference type="EnsemblBacteria" id="AGN00812">
        <property type="protein sequence ID" value="AGN00812"/>
        <property type="gene ID" value="L593_04305"/>
    </dbReference>
    <dbReference type="GeneID" id="16180892"/>
    <dbReference type="KEGG" id="sali:L593_04305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.876"/>
    <dbReference type="eggNOG" id="arCOG00504">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_1_2"/>
    <dbReference type="OrthoDB" id="103066at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="201" mass="21929" checksum="5208B40BE30494AE" modified="2013-07-24" version="1">MHVHTVTADAETFTCNAYLVTGEHTVLVDAGAMDGVEDVIAEHTDSLDAVALTHQHGDHVDALDAVLDAFDADCYAFGAHPRRSHVLEDGDHLQIGDESFEAVYTPGHADDHLAFVSDSTLFSGDVVVHDDGAFDYGSFGRTDMPGQSRERLVESIEDLLDRLPDSVEHMYAGHGDEFHGDVRDVVETALGRAEKHEPKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W412</accession>
    <name>R4W412_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445741.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04480"/>
    <dbReference type="EnsemblBacteria" id="AGN00847">
        <property type="protein sequence ID" value="AGN00847"/>
        <property type="gene ID" value="L593_04480"/>
    </dbReference>
    <dbReference type="GeneID" id="16180961"/>
    <dbReference type="KEGG" id="sali:L593_04480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.913"/>
    <dbReference type="eggNOG" id="arCOG01145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292004_0_0_2"/>
    <dbReference type="OrthoDB" id="49505at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="212" mass="23423" checksum="973E119533456C78" modified="2013-07-24" version="1">MLVLGDAHADEQSNRSALLAAYEEADADTALQVGDLLYYDLPVPTWFVAGNDEDLDVVESLRTGSDADRTRNVHLLASTAVERHGIRVAGLSGNYAPTQFDRPRSELENDRRRHFVSDDVERATELTDVDVFLAHEAPHGLLQSDGYDVGCKHVDAILRALTPDRCLVGHHHEHVESTFGDTTVVGLAPVWESYYTLDPETIALERHPSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4I8</accession>
    <name>R4W4I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446046.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06015"/>
    <dbReference type="EnsemblBacteria" id="AGN01152">
        <property type="protein sequence ID" value="AGN01152"/>
        <property type="gene ID" value="L593_06015"/>
    </dbReference>
    <dbReference type="GeneID" id="16180096"/>
    <dbReference type="KEGG" id="sali:L593_06015"/>
    <dbReference type="eggNOG" id="arCOG03050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_19_1_2"/>
    <dbReference type="OrthoDB" id="91735at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="15402" checksum="4AADDD61E17EA8EC" modified="2013-07-24" version="1">MYRILLPVDIEESRALAQADYVAELPGAADAVEVFILFVFDESDDDIPDEYKRFNTATRIGAVRRASERLEEAGVEMHVLDESGDAATRILEEAEEREVDSIVIGGRKRSAVGKAIFGSVTMDVIRDTSLPVTVTGKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4J2</accession>
    <name>R4W4J2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="8" type="ORF">L593_06065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446056.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06065"/>
    <dbReference type="EnsemblBacteria" id="AGN01162">
        <property type="protein sequence ID" value="AGN01162"/>
        <property type="gene ID" value="L593_06065"/>
    </dbReference>
    <dbReference type="GeneID" id="16181663"/>
    <dbReference type="KEGG" id="sali:L593_06065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1242"/>
    <dbReference type="eggNOG" id="arCOG02173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_2_1_2"/>
    <dbReference type="OrthoDB" id="64973at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="36"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="28635" checksum="47ECE3F50F677B1B" modified="2013-07-24" version="1">MPVATDVSDVGSEDTPEAAALPINELFYSLQGEGKLAGVPSVFVRTSGCNLRCWFCDSYHTSWEPTGAWLTIDKLVEQIAEFDAAEHVVVTGGEPMIHDDTEELLEELADRGFHTTVETNGTIYRDAPIDLASISPKLASSTPTEELDPKGAGEWAERHENRRIDVDTLSDLVDAYDSQLKFVVTGPDDMAEIEDLLVRLRETADTEIENNDVLLMPEGMTREELDERRGTVAELAQDHGYRYTPRLHVDLWNDAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4W0</accession>
    <name>R4W4W0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_020446256.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_07075"/>
    <dbReference type="EnsemblBacteria" id="AGN01362">
        <property type="protein sequence ID" value="AGN01362"/>
        <property type="gene ID" value="L593_07075"/>
    </dbReference>
    <dbReference type="GeneID" id="16182266"/>
    <dbReference type="KEGG" id="sali:L593_07075"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1446"/>
    <dbReference type="eggNOG" id="arCOG00517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_2_2"/>
    <dbReference type="OrthoDB" id="25677at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="370" mass="40027" checksum="EF65DE84AFD02C4F" modified="2013-07-24" version="1">MTDIAPDELAERLQAEEDDPLVLDVRHQEDFEDWHVPTSVNVDVYEELVDDPETAKEPLAELPDDEPIVTVCAEGVVSQTATEVLEDLGYDALTLTDGMSGWSRVHEHAAVSADLDGQLLQVARPGKGCLSHVLVSDGDAAIFDPSHYLDVYDDVVDAHDADLVGVFDSHAHADHVSGGRDLADRHDVPYYLHPQDALAIDATPVEDGRRVAVGDVEIEVVHTPGHSEGSVTFDLVGAALLTGDTLFHDSVGRVKLGVEAGIEDSDVESNAATLYESLERLLDRPDDALVLPAHDPGSPRPPVTARLGDLPERNADLRRDRGAFVETLAADVPDHPPNFERVKRTNVGQESVPDEELSDLELGPNRCAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Y5</accession>
    <name>R4W4Y5_9EURY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446301.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01407">
        <property type="protein sequence ID" value="AGN01407"/>
        <property type="gene ID" value="L593_07310"/>
    </dbReference>
    <dbReference type="GeneID" id="16182148"/>
    <dbReference type="KEGG" id="sali:L593_07310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1493"/>
    <dbReference type="eggNOG" id="arCOG08129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271150_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="11068" checksum="633F4FDBC0BA290E" modified="2013-07-24" version="1">MACSQQAVDARVDCTVRVARDADGTLADGAETQLARVEGVEVVEPVDVAGLTPRLNDLAVDVQARVRVVDERRRDDEPPDELVRQRLADGFGVDVSEVAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5E9</accession>
    <name>R4W5E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01692">
        <property type="protein sequence ID" value="AGN01692"/>
        <property type="gene ID" value="L593_08735"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08735"/>
    <dbReference type="HOGENOM" id="CLU_2565893_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="8343" checksum="D23E194C58D02C87" modified="2013-07-24" version="1">MDGAYPADRASVQVQSGQSRRPWQLIVAVPHRGQSSAPGVTASTLEVVGAVAGDDSEGAFGPAPGRVWSVVGIHTNGPHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X0</accession>
    <name>R4W5X0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444932.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00415"/>
    <dbReference type="EnsemblBacteria" id="AGN00038">
        <property type="protein sequence ID" value="AGN00038"/>
        <property type="gene ID" value="L593_00415"/>
    </dbReference>
    <dbReference type="GeneID" id="16181886"/>
    <dbReference type="KEGG" id="sali:L593_00415"/>
    <dbReference type="eggNOG" id="arCOG04989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006927_0_0_2"/>
    <dbReference type="OrthoDB" id="129090at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="30423" checksum="68AABD96369CC234" modified="2013-07-24" version="1">MALGAIRNAIGAVTSWSQVLLRGLRNPQQIPPFVVGTVFPESRWGPNWRKKDGFITFDDGGFAGGDPSRPELSARLYRESRHLDSVLGNRSYDRALELGCGYGRLTGWISEHAEETIGVDPNGDAIERARTLYPELEFEETLGQDLPFEDDSFDLIVSWNVLQHIPPDAVGEVASELRRVLAEGGTINCCEMTSGDGGRASWVRSRAEYESLFAPLTLVDVDERPAERTFEYANRGEAMVFERDGGAPRGIATSNRTRPVREHGPATLQKSSAESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W613</accession>
    <name>R4W613_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">L593_10535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446946.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10535"/>
    <dbReference type="EnsemblBacteria" id="AGN02052">
        <property type="protein sequence ID" value="AGN02052"/>
        <property type="gene ID" value="L593_10535"/>
    </dbReference>
    <dbReference type="GeneID" id="16182034"/>
    <dbReference type="KEGG" id="sali:L593_10535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2172"/>
    <dbReference type="eggNOG" id="arCOG00024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_2"/>
    <dbReference type="OrthoDB" id="25345at2157"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
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    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
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        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="272"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="513" mass="56422" checksum="D63721F7958B285B" modified="2013-07-24" version="1">MSANTYVGAIDQGTTGTRFMVFDHGGQVVANAYETHEQYYPEPGWVEHDAMEIWETTKEVVTEALESADIDAEQLEAIGVTNQRETTVLWDADSGSPVHRAIVWQDRRTTDRIEELESEDKVGDIRAKTGLEADAYFSATKAEWLLENADPVKTGRARPADVEERAAEGQVMFGTIDSWLIYNLTGNHITDVTNASRTMLFNIHEMDWDDELLDEFGVPEAMLPEVRPSSDEDTYGTTDPDGFLGAEIPVAGALGDQQAALFGQTCFDAGEAKNTYGTGSFFLMNTGDEAVESEHGLLTTVGYQRSGEPVQYALEGAIFITGAAIEWLEDVDLIEDAGETESLAREVDSTDDVYVVPAFTGLGAPHWDGRARGTIVGITRGTRKEHIVRATLESIAYQTRDVAEAMEDDSGVEMATLRVDGGAVKNNFLCQLQADIIDTDIARPEVDETTALGSAYAAGLAVGYWDDVEGLRDNWVVDREFEPDMDATEADRLYDRWEDAVERSLDWARDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W616</accession>
    <name>R4W616_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_10560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446951.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10560"/>
    <dbReference type="EnsemblBacteria" id="AGN02057">
        <property type="protein sequence ID" value="AGN02057"/>
        <property type="gene ID" value="L593_10560"/>
    </dbReference>
    <dbReference type="GeneID" id="16180785"/>
    <dbReference type="KEGG" id="sali:L593_10560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2177"/>
    <dbReference type="eggNOG" id="arCOG02322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_2"/>
    <dbReference type="OrthoDB" id="10018at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="224"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="365"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="538" mass="56511" checksum="8D56F109DE9D73CC" modified="2013-07-24" version="1">MQLHTVVPAAIRRRYGAKVAGWCLLVGLAVGAAHAGVAYWLLAGADGDAVTTDALLTGIAGIGSATAAGLLLLAVVLGRGTGRSLRSLADDAEAIAAGDYQRDVETARIDDLGRAHDAIAELRDGTEARIEELEAERQHVEAARRSLEVDNDELLAEAERFSEVLDACADGDLTRRLDAQTDHEAMAKVAGSVNRMLSELERAVVQVARFAEVVDDASSELQASAQEIGEASDAVSKSVREISEGSSRQTDDLQAAAGQVRELSATIEEVAATTSTIAKEAERVSGLADDGVSTATTAADQMHEAEDHTARVANTIARLNEDAERIAESITLIDDIAQQTNMLALNAAIETARTDQDRTGDNGGFDVVADEVQELSAEIQEAVDEIQETIASLQARATETADEIGAVEHRITAAVDSVDDLEAELVTVSDRVENVSDSVHEIDHVSNDQASTVEALAGLVENVAMVSAETSREADRVADASADVAVEIGEVSAKARSLDSQADRLTDVVGQFDVSTRQQLQSSGEAVPAPSASQDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W685</accession>
    <name>R4W685_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl24p</name>
        <name evidence="2" type="synonym">rpl24</name>
        <name evidence="5" type="ORF">L593_11160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447071.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11160"/>
    <dbReference type="EnsemblBacteria" id="AGN02177">
        <property type="protein sequence ID" value="AGN02177"/>
        <property type="gene ID" value="L593_11160"/>
    </dbReference>
    <dbReference type="GeneID" id="16182336"/>
    <dbReference type="KEGG" id="sali:L593_11160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2302"/>
    <dbReference type="eggNOG" id="arCOG04094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_2_1_2"/>
    <dbReference type="OrthoDB" id="107015at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="13538" checksum="0788B254EC0A7EA1" modified="2013-07-24" version="1">MSKQPRTQRNQTANADLHERHDQVRSTLADDLREEYGTRRVRVNQGDTVEVMRGDFAGESGEVLRVDLKDAVVHVEDVTVETADGEEVPRPLDASNLKVTGLEVDRDPERESRIRGEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W690</accession>
    <name>R4W690_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TrkA-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_01275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445102.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01275"/>
    <dbReference type="EnsemblBacteria" id="AGN00208">
        <property type="protein sequence ID" value="AGN00208"/>
        <property type="gene ID" value="L593_01275"/>
    </dbReference>
    <dbReference type="GeneID" id="16180374"/>
    <dbReference type="KEGG" id="sali:L593_01275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.260"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_2_2"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="24459" checksum="E3947FA5E7A5A3F5" modified="2013-07-24" version="1">MRFVIIGAGRVGLRTARVLKEEGHDVVLVERDSAKVERARGQGYDVVEGDGSREEMLEEAGIEEADALGALTGDLNVNFAACMIGKHRGARTVLRIDEDYREEIYRKYAAEVDEIVYPERLGAIGAKNALLGGDIRAIADIAQHLQVVELTITMQAPIRGYSISELQLPADATVLAFGKSDGPLGIPSSDESLEDGDRIVVLADFDVLDDVRQLVVGEAGRAAAGGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6D6</accession>
    <name>R4W6D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01835"/>
    <dbReference type="EnsemblBacteria" id="AGN00318">
        <property type="protein sequence ID" value="AGN00318"/>
        <property type="gene ID" value="L593_01835"/>
    </dbReference>
    <dbReference type="GeneID" id="16179965"/>
    <dbReference type="KEGG" id="sali:L593_01835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.371"/>
    <dbReference type="eggNOG" id="arCOG04347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051421_0_0_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051741">
        <property type="term" value="F:2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044649">
        <property type="entry name" value="MPBQ/MSBQ_MT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031164">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516">
        <property type="entry name" value="PTHR44516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51734">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MPBQ_MSBQ_MT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="206" mass="23302" checksum="9F58B26147B985AB" modified="2013-07-24" version="1">MGFLEDKARARLFYKYLSRIYDRINPYVWTETMRDDAIDRFDVDDDDRVLDVGCGTGFATQALVERTDDVYGLDQSPHQLERALAKLGDDDRVEFHLGDAERLPYETDSFDAVWSSGSIEYWPEPVRTLREMRRVCKPGGTVLVVGPNEPKSRIGKALADAIMLFYGAAEADRMFEAAGYESVEHWTDGPSHKPDVAVISMAQVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H8</accession>
    <name>R4W6H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445292.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02235"/>
    <dbReference type="EnsemblBacteria" id="AGN00398">
        <property type="protein sequence ID" value="AGN00398"/>
        <property type="gene ID" value="L593_02235"/>
    </dbReference>
    <dbReference type="GeneID" id="16180131"/>
    <dbReference type="KEGG" id="sali:L593_02235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.453"/>
    <dbReference type="eggNOG" id="arCOG02610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070251_0_0_2"/>
    <dbReference type="OrthoDB" id="81037at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="39719" checksum="180DF1069EC15D5F" modified="2013-07-24" version="1">MTDGTPGEAAQSAEDESDDVPLDIAGHEERTPPGADEDEPDAIDEEDVAANGGAATLETGTPNASAGPVEAEDLIADDLAEEAGIGDTGDGEDDADSVDADDDDEEVEPIELLVQLAKDGEIDPWDVDVVDVTEEFLAALEEGSLRESGRALFYASVLVRMKSDVLLEPDAAEEQAEDPWDAPMESPEDAPPAFDPIDSLEAEMDRRLQRKHVRGTPETLDELVRELREAERGSWWKEGREYDTSGSPAGFDRGTQTVDYHMNDDRRMEGEPTAAEVTERTHGEDIEEIIDTVRAELTEHYDAGRPEVLFREVEDSGGSRVHTFLAILFLANRSEVRLQQDELFGDLWIQDPTADLGVEGAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N0</accession>
    <name>R4W6N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447316.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02422">
        <property type="protein sequence ID" value="AGN02422"/>
        <property type="gene ID" value="L593_12415"/>
    </dbReference>
    <dbReference type="GeneID" id="16179978"/>
    <dbReference type="KEGG" id="sali:L593_12415"/>
    <dbReference type="eggNOG" id="arCOG14944">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140310_0_0_2"/>
    <dbReference type="OrthoDB" id="109009at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="112" mass="12064" checksum="2C70E31F7F8C06C8" modified="2013-07-24" version="1">MADYALHEPDYSGTTTQDWDAPQESDFDTDDLGDIADHFLLSASGFPPENFTDLKLPVVDPDGKLNENALQSAHGGAHSVDEIDGIDDETAADTKDAIEDLARDGFHEDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6R4</accession>
    <name>R4W6R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447371.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12690"/>
    <dbReference type="EnsemblBacteria" id="AGN02477">
        <property type="protein sequence ID" value="AGN02477"/>
        <property type="gene ID" value="L593_12690"/>
    </dbReference>
    <dbReference type="GeneID" id="16180400"/>
    <dbReference type="KEGG" id="sali:L593_12690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2604"/>
    <dbReference type="eggNOG" id="arCOG04730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188093_0_0_2"/>
    <dbReference type="OrthoDB" id="114315at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="10403" checksum="7AAD56278C2E57AF" modified="2013-07-24" version="1">MDRISALRNVEDALSEFERGEIDLASMEQQIQAVLRTYATDFEDERTAVYRVDPIEDRAVVIVANSPGEARDRAAAQVGGDCEHADVERLGGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6R9</accession>
    <name>R4W6R9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rpl37ae</name>
        <name evidence="3" type="ORF">L593_02935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445432.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02935"/>
    <dbReference type="EnsemblBacteria" id="AGN00538">
        <property type="protein sequence ID" value="AGN00538"/>
        <property type="gene ID" value="L593_02935"/>
    </dbReference>
    <dbReference type="GeneID" id="16180407"/>
    <dbReference type="KEGG" id="sali:L593_02935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.594"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_0_2"/>
    <dbReference type="OrthoDB" id="122290at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="10434" checksum="2EB611AABE95DA46" modified="2013-07-24" version="1">MSSNSSRTGSAGRFGARYGRVARKRVAEIEADTRDDHECPECGRERVVRTDTGIWECETCNYTFTGGAYRPQTPAGTTVRRSIRAALAEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6W8</accession>
    <name>R4W6W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445507.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03310"/>
    <dbReference type="EnsemblBacteria" id="AGN00613">
        <property type="protein sequence ID" value="AGN00613"/>
        <property type="gene ID" value="L593_03310"/>
    </dbReference>
    <dbReference type="GeneID" id="16180353"/>
    <dbReference type="KEGG" id="sali:L593_03310"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.670"/>
    <dbReference type="eggNOG" id="arCOG04597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069982_0_0_2"/>
    <dbReference type="OrthoDB" id="93930at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="316" mass="33422" checksum="2BD0F2FD2993F7BA" modified="2013-07-24" version="1">MTDSPDPAASDPPSKDGASTDAASGSEAADALDDGAVAAESDGHSAEARAAGTEESEELAELRQRVEEEYDFEDFGPADMAQMDPEEWDVAFDADTWITGEALLDRVEADLKNRVATRNVFAVVERVTHEGQPCVLAYTDSGYALVEPDGSVEGFGTVLRDTKPVVALCSMESYDVAPMPDEDYLLPHPEEVPEGSDELGNLMMQVVAGVLSLAGVLLVIASFYAVAASYGAPGVAGLTNAGGGALAVTIVIGFVFVGVGLTLFATVANARLSDAFRAEEYRERLRRMGLDDGERPAFLPTESTTRELTDEDRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y3</accession>
    <name>R4W6Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447481.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13240"/>
    <dbReference type="EnsemblBacteria" id="AGN02587">
        <property type="protein sequence ID" value="AGN02587"/>
        <property type="gene ID" value="L593_13240"/>
    </dbReference>
    <dbReference type="GeneID" id="16180492"/>
    <dbReference type="KEGG" id="sali:L593_13240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2709"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15608" checksum="D17EA92949156AE2" modified="2013-07-24" version="1">MSSESTRDRILSVLETDAKASYGEIAERADVSKPTVRKYIDQLESEGVIVGYSAEIDPKKLSGQSIALVGMDVESERYVEATRRLQELEEIEALYTSSGDHMLMAEVRAGDGDELGDVISEEILTIDGVTAAHPSFLQERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y6</accession>
    <name>R4W6Y6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">L593_13265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447486.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13265"/>
    <dbReference type="EnsemblBacteria" id="AGN02592">
        <property type="protein sequence ID" value="AGN02592"/>
        <property type="gene ID" value="L593_13265"/>
    </dbReference>
    <dbReference type="GeneID" id="16180469"/>
    <dbReference type="KEGG" id="sali:L593_13265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2714"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OrthoDB" id="117225at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="19794" checksum="E8D96DA54339E755" modified="2013-07-24" version="1">MTDRTLIDALRDADAVQFGEFELSHGGTSDYYVDKYRFETAPECLELIAEAFADRLDEDDGGAASAADGPKLAGVALGAVPLVAVTSVETGRPYVIVRKQRKEYGTANLVEGELADGEEVVVLEDIATTGQSAADAVEALRDAGATVDRVLVVVDRQEGAAELLADHDVELESLVTAEDLLADAEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W776</accession>
    <name>R4W776_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_04260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04260"/>
    <dbReference type="EnsemblBacteria" id="AGN00803">
        <property type="protein sequence ID" value="AGN00803"/>
        <property type="gene ID" value="L593_04260"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.867"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003088_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="807"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="839"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="295"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="703"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="895" mass="93930" checksum="13C6EE49FF9635B4" modified="2013-07-24" version="1">MSDLAEAIVDHRRLVIVAFLLVTTGMIAGAMQVEEQSSLDGFQTDSEEAEALDRIQARYDRTGENVTTAQVVVERENVLSKEGLLEALRYQRALRQNETVAGTLAHRPGQQATTSVASAIATAAIARERRVGNARGQSADRSGDANGTAAATGSGGVPSMDAQIAQIESMSDAEIEATIQAVLTEDRAELLMLLPADYEAGETTADATMVLVRQDTRGEFVSIDTAPEFLVESQQAMAAIGEERGGATYRVFGVGITADEFATSMNESLAILGPFALLFVLLVLAIAYRDVVDVLLGLTGIGLVLVWTFGFMGWAGIAFNQLFVAVPVLLIGLSIDYAIHVFMRSREARDRGRAFGSDATGTATPSADAMKRGLAGVGLALVLVTVTTAVGFLSNVVSPLPPIQEFGIVNAAGIVSALFVFTLFVPAVKVELDGFLESHGFDRRTSAFGSSGRLNGLLAGASRVARRAPAIVLVLALLVSLGGAYGATQVDSSFQTTDFLADDPPEWTESLPAGMQPSEYTAIGTMDVLEDEFVRQDLDAQLLIEGNVTDPAALERIGGATTRLGDTEAAARLPNGRAALTSPTTAMERVAATNESFNATLAASDTDGDGLPDRNLEAVYDALYAADPVTAAGVIDRTESGEYRSVRITVLAASSDETGSLVSAVRDESDRIEGQGTPADGPGPSVEVTPTGQRTVITQQISKQILDTVLWSLVVTLAVVGVLLLGAYRLTAGRGSLGIVAMVPILMALSWVLGTMWLIGMPFNSITGLITSLTIGIGVAYSIHVCERYYQELDRNETVDDALHATVAGTGGALLGSAATTAGGFGVLTFAFLPALQQFGLITAVSIGFAFLATVAVLPSLLVIWTRYLGPEWASEELAADPPVSVPHTDPASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D2</accession>
    <name>R4W7D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447736.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14515"/>
    <dbReference type="EnsemblBacteria" id="AGN02842">
        <property type="protein sequence ID" value="AGN02842"/>
        <property type="gene ID" value="L593_14515"/>
    </dbReference>
    <dbReference type="GeneID" id="16181291"/>
    <dbReference type="KEGG" id="sali:L593_14515"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2968"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_5_2"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="390" mass="43162" checksum="680783C95C5F1D96" modified="2013-07-24" version="1">MDLLEESIVPEHARPVKQEARSFAEEHVEPNAEVCFREAEYPWDVLEAARDANLIAQDIPEEYGGRGLSLTEVLAIAEEFFRADAGIALTLQLASFGAELVMEYGSEEQKETYLRPVAEGDQLTGLAVSEPETGSDLAGMQTRAEFDDDGADGEGEWVLNGEKYWIGNGVEADWLTVYARTGDDETNRYGNHTCFVVPTDADGYHAEHIPEKMGMRASKQAHVVFDDCRIPADNVIGTEGAGFWMLAEFFNHGRIVVAGHGLGLAAAAIEEAWSFTHDREEFGRSISDFQSVQHGLADMRMDFESARALTWRAAAKVEAGERPGFWAAMAKTVATEAATNCAERGMQFHGGRSILSDRRIARVYRDVRIPVIYEGANEIQRNLVYRQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7E3</accession>
    <name>R4W7E3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00923">
        <property type="protein sequence ID" value="AGN00923"/>
        <property type="gene ID" value="L593_04870"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04870"/>
    <dbReference type="eggNOG" id="arCOG10128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172992_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="42" mass="4543" checksum="A7A80AEA4B0608AB" modified="2013-07-24" version="1">MSNSSEVSDDAACDVSHVDDVEDGCGCVEVWEHLSEQRTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H8</accession>
    <name>R4W7H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447811.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14915"/>
    <dbReference type="EnsemblBacteria" id="AGN02917">
        <property type="protein sequence ID" value="AGN02917"/>
        <property type="gene ID" value="L593_14915"/>
    </dbReference>
    <dbReference type="GeneID" id="16181573"/>
    <dbReference type="KEGG" id="sali:L593_14915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3046"/>
    <dbReference type="eggNOG" id="arCOG06880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881685_0_0_2"/>
    <dbReference type="OrthoDB" id="93244at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="319" mass="34283" checksum="1CAEA101A6008BDA" modified="2013-07-24" version="1">MPTTYYDVLGIESDATQDEIRDAYREKVKEYHPDVSDHPDAEERFKRVKRAEIVLADPEERSTYDRLGHDAYVDGDDPAPNQPTENEVHWAAAKAAQGEHDAGGGRSAGWRDRESRAHASGRAEWFWNDDSDRESNDNPFDGRSSRRESSANSAGPSGDPGSAPGGSSTATAHASAHVASHTAPDGWGDTDPDAGAHAVHEWGPAERTIGNPRPSWTQDDVVLLLSSLLLYPILLFLTVTPAFPMVARVAIGICTIALVAFLLPRPSFGLPVFGSWSILVPALLLGFGISPLSAAGLVTLGGVWLPLVYSIAVAMVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K4</accession>
    <name>R4W7K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_15140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447856.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15140"/>
    <dbReference type="EnsemblBacteria" id="AGN02962">
        <property type="protein sequence ID" value="AGN02962"/>
        <property type="gene ID" value="L593_15140"/>
    </dbReference>
    <dbReference type="GeneID" id="16181768"/>
    <dbReference type="KEGG" id="sali:L593_15140"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3092"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="322" mass="33884" checksum="49BB77AD97A975E7" modified="2013-07-24" version="1">MCPVLAAEDVRKTYGETIALDGVSLAAEEGAVVALVGPNGAGKTTLVRSLTGTITPDSGTIRVLGTVPEDVDRNPLGVLPQSFEPPGRLSAIELLRYYAGLYDDARDPHEVLETVGVADAANTRYENLSGGQQRRVCLGAALVNDPAVLILDEPTTGIDPEGRRTVRDQIASLADGGATILVTTHDMDEAERIADRVVLLADGRVSATGSPSELIEEHGGAPRVIVEFADEASIDAAVAALERDGLDVERERDRVVVRDVRPESIESVVEVLGSAGVDYEGLEWRRPALEDAYLAVAGEASRIAATATAGQQSSPTVGGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7L1</accession>
    <name>R4W7L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445917.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05370"/>
    <dbReference type="EnsemblBacteria" id="AGN01023">
        <property type="protein sequence ID" value="AGN01023"/>
        <property type="gene ID" value="L593_05370"/>
    </dbReference>
    <dbReference type="GeneID" id="16181339"/>
    <dbReference type="KEGG" id="sali:L593_05370"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1097"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OrthoDB" id="24323at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="112"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="563"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="675" mass="74922" checksum="BAAA09DB30E977A5" modified="2013-07-24" version="1">MDTLEDIDEVVHEPDREFVESTNVWQFMQRYGIDDHEELIERTTTEVEGEPDSGVEWFWDVLPDELGIEFDEDYDRVRDDSDGPQFTDWYPGGKINAAHNVLDRHAARDTGARNHVACIWEGEPGDVRRITFQDLRKQADRVANALEDRGIETGDTVGLYMPMVPEVISILYGCLKVGAIAVPIFSGFGVDAVETRLSDAGCSVLFTADGFYRRGDEVYLKDTADEAIAAAREAADESVVEHTIVYDRLGASDPDSGVDVLWHEDRDEWWADSVAEADDHYETKSLPSQHPAMLLYSSGTTGQPKGIVQPHAGALLQSAKEIYFGFDHQPSDRFFWVSDIGWMMGPWTLLGNHAFGGTIFMYEGAPDHPEPDRFWRMIDEHELSVFGISPTAIRALKKQGEEWLEGHDLSSLRLLGSTGEPWDPESWKWFYDEVGGGECPIVNISGGTEIFGCFLMPMPIQSLKPCTLGAPGLGMDVDVVDPDGESIVDTTDRGFLVARDSCPSMTQSLWSGDERYLAEYWSTWDDLWDHGDFAQRDADGFWFLHGRADDAINVAGRKVGPAEVEGALIDHADVNQAAAVGVDDETTGQAVVAYVVVEPGVAETEDLRDALVGWVGEEIGKPFRPRELFFVDAFPKTQSGKIIRRAIAGTYEGEELGDMSSIENPEALDAIEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T0</accession>
    <name>R4W7T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_00395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444928.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00395"/>
    <dbReference type="EnsemblBacteria" id="AGN00034">
        <property type="protein sequence ID" value="AGN00034"/>
        <property type="gene ID" value="L593_00395"/>
    </dbReference>
    <dbReference type="GeneID" id="16181845"/>
    <dbReference type="KEGG" id="sali:L593_00395"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_0_1_2"/>
    <dbReference type="OrthoDB" id="65191at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="30104" checksum="9FBB9D8170275735" modified="2013-07-24" version="1">MSVGIVAKKDFRDAIQSRALWALVGTFIVLSVITTYGYTEAPELFGTQEEATFGGLVFFTLGFTALFVPIAAIIVGYKSVAGEREIGSIKLLLSQPTTRRDVFLGKVLGRAAVLATGLAIGLVVGLLFGALLIGGLNAWALVAFVALTLLFVAVYSAVMVSISATTGSTTRATTLAIGFFVLFELVWDVVPLMIVYVVEGFQFTTDYPDWAYIVTNVSPSTAYSSGLFALLPGVADSLEASSDAGSETDAFYQTPELGLVMLVLWIVVPLLVGYYQFNRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7T3</accession>
    <name>R4W7T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin--nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446077.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06170"/>
    <dbReference type="EnsemblBacteria" id="AGN01183">
        <property type="protein sequence ID" value="AGN01183"/>
        <property type="gene ID" value="L593_06170"/>
    </dbReference>
    <dbReference type="GeneID" id="16181647"/>
    <dbReference type="KEGG" id="sali:L593_06170"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1260"/>
    <dbReference type="eggNOG" id="arCOG02055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_2_3_2"/>
    <dbReference type="OrthoDB" id="4523at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="328"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="408"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="582" mass="64887" checksum="B8BB513D728690B3" modified="2013-07-24" version="1">MNSVEQYKQNKHPLDVIEDVKEYAEKGLSFEEIEERAGGGEWERLKWAGMYSHGVQDGYFMMRTKVPGGKLTPEQAEVVGEVADEYATAPEKYGGEHQNEHWGDAYLDITTRQDTQSHWIEVEDVPEIWEKYEEVGLTTIQGCGDSARNVLGCPAAGLDDHECFDAQPVIDAVSEYFTENREYANLPRKYKMTITGCREDCAQSQINDVGLTPARKEIETDGAGQSTEEIYGFHAKVGGGLSDGPRMASPLDVFVRPEDAVEFCRAVAQTFKEIGDRNNRGVCRMRYLVEQLGPETFEEAIRDRCEVDLRSRGTDLTEGYKGDHVGVHEQKQDGLNYVGFNVITGRMGGEEFAEVARAAKQYGTEDASIRLATDQNFLITHIPDENLDDLLAEDFAQEYKPDPGPFERGAVGCTGSEFCNYGIIETKKRVKRWARELDERIDTPDDLEVVRMHMSGCSASCAQPQIADIGFRGETVKMTGESESDAPQSPEAENEESDMVEGMDFGLGGALGSDNEFLDWVETAVPADAVIPALEELFAAFAREHEEGERFYEWCRRTDNERLRRVMQGADAPVAKGVAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U6</accession>
    <name>R4W7U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
            <shortName evidence="6">GDH</shortName>
            <shortName evidence="6">GlcDH</shortName>
            <ecNumber evidence="6">1.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gdh</name>
        <name evidence="9" type="ORF">L593_00670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444983.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00670"/>
    <dbReference type="EnsemblBacteria" id="AGN00089">
        <property type="protein sequence ID" value="AGN00089"/>
        <property type="gene ID" value="L593_00670"/>
    </dbReference>
    <dbReference type="GeneID" id="16180631"/>
    <dbReference type="KEGG" id="sali:L593_00670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.136"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_1_0_2"/>
    <dbReference type="OrthoDB" id="43162at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047934">
        <property type="term" value="F:glucose 1-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047935">
        <property type="term" value="F:glucose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019595">
        <property type="term" value="P:non-phosphorylated glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02127">
        <property type="entry name" value="Glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026583">
        <property type="entry name" value="Glc_1-DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="7">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="8">
        <location>
            <begin position="150"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="362" mass="39339" checksum="5BC9F0C51E8A17AA" modified="2013-07-24" version="1">MRAIAVGRGETDPTVVEIDEPEPAEGEALIRTLRVGIDGTDHEVIGSNHGGYPEGEDFQVLGHEAIGVVEDPNGTDLEAGQLVVPTVRRPPGGDAFGSGAEPNEYFERNEPDMAPAGEYVERGIAGAHGYMAEYFTSEPRYLVPVPDEFAEIGFLVEPISNSEKAFDLAEASRSTFEWDPESAIVLGNGPLGLLTLAMLDDRGFDRHYCLGRRDRPDPTIDIIEELGATYVDSRETPVDELPGAEEPMDFVYEATGYAPHAFQTIDALAPNGVGVLLGIPGEWEFEIDGGALHRDFVLENKALLGSVNSHVPHFEAAVETLAGMPEWFTDAIVTHVFDPEDVDEAFETGDDRIKVVVEFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X2</accession>
    <name>R4W7X2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06655"/>
    <dbReference type="EnsemblBacteria" id="AGN01278">
        <property type="protein sequence ID" value="AGN01278"/>
        <property type="gene ID" value="L593_06655"/>
    </dbReference>
    <dbReference type="GeneID" id="16181835"/>
    <dbReference type="KEGG" id="sali:L593_06655"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1359"/>
    <dbReference type="eggNOG" id="arCOG00077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_2"/>
    <dbReference type="OrthoDB" id="52784at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:nucleoside metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GcvPA"/>
    </dbReference>
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        <property type="entry name" value="GDC_P"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="443" mass="47860" checksum="0E98F9629C78F9D8" modified="2013-07-24" version="1">MTGHDTGTPFAPHTPEETAAMLDAVGAETVEDLFDVPDSVRFDGEFGIESRDEQTVRAEFTEQLDDTDEQIEFLGRGHYDHYVPSAVEHLADRSEFLTSYTQYQPEVAQGFLQALFEYQSIVVELTGLDVANCSLYDAATALGEAALLAKRVRATSGDVVLVPELLREERRSVLENYVGGTDLRVEAYPHDDGVADVEALRGRVDADVAMVYAESPTVRGTLDPHLAAIGDLADEHDALFTLGSDPIALSVLERPAVLGADVVVGDASVLGLPASFGTGLGLFATRDEFLRQVPGRLVGASEDADGNRAYTLTLQTREQHIRKERATSNVCTNQAWVALRSAMHAVSLGPEGLVELAQTCIEEPASLAATIDDLPGYAAPVHDKAHFREFVVETDASAATIGAGLREEGFAVHVLDEDRLQLCVTDTNREHVGDLVEAMEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W834</accession>
    <name>R4W834_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_01580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445163.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01580"/>
    <dbReference type="EnsemblBacteria" id="AGN00269">
        <property type="protein sequence ID" value="AGN00269"/>
        <property type="gene ID" value="L593_01580"/>
    </dbReference>
    <dbReference type="GeneID" id="16179866"/>
    <dbReference type="KEGG" id="sali:L593_01580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.321"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_793672_0_0_2"/>
    <dbReference type="OrthoDB" id="75045at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="428" mass="46675" checksum="27FBFBD3FA6A03DE" modified="2013-07-24" version="1">MRVAVVSPETIHHRDADDTRRLQRLVRGLDDRGHEVTVCCGRWWDGEDAETGDGPVADADPDETSPADTDDLPTGDPDQLPPAGTPAAGEDADRAPDESGVAASQGDAFATEDDARSNDDVESTVTVDGITYRAVVADATDHRSFATWTPLAIRKCNPDVIHAVATPPSTVVAARVGATIARAPVLAEWYDPSLSEGGSWTTSQALKRPGRIVTPSRLTRRQLLELGADDAKLQVIPNAIDLDQIESVDPADEGDVVYARRLDEDANLESLFLGLAELRDRGWSATIVGDGPARHEYEQQAKDLRIDDRVTFVGACDREERVSIYRGAHAFVQTARRCVFATELCWALACGCVGIVEYHADSSAHELVEGRDRGFRTTNPRETAQAIRDAGGLERLAIDESFASFDESTVLEQYESCYQDLREQWGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W874</accession>
    <name>R4W874_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446437.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07990"/>
    <dbReference type="EnsemblBacteria" id="AGN01543">
        <property type="protein sequence ID" value="AGN01543"/>
        <property type="gene ID" value="L593_07990"/>
    </dbReference>
    <dbReference type="GeneID" id="16182283"/>
    <dbReference type="KEGG" id="sali:L593_07990"/>
    <dbReference type="eggNOG" id="arCOG06250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759964_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="35789" checksum="D25678C3BFBAE435" modified="2013-07-24" version="1">MIVAALIALLGLAIVAVSARPGDGRAETAIAVPLVAAVAVLVPVAAAVLLAGAALAYGVLAVVTSRTLLYGRRLRAIAAVAGAVVPLGALAANTALGSPPGYPELLIVGAVVPGVLADDVRRQPRDRRGPIAIGGIATLLALALSGLVLRGSLAGAELSSIVDADAGSTLGAGSLAVLGGVLLLAVVTATLLRWRYAIGVGPISIPLVAVWSIDGVAVPVTYLLAALASTIAIAAVQPRLCLPGRQLSATVGLLGATVGVIAALAGAPGLPAILAGTFAAEDARLLRHHAGADLLDAVALDGAGYVLVVVALFAAAGGAGVLPGVLGGVGAVLAIVTIGTVLARRERERPVEERLRAAEGRWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W890</accession>
    <name>R4W890_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leucyl aminopeptidase (Aminopeptidase T)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446472.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08165"/>
    <dbReference type="EnsemblBacteria" id="AGN01578">
        <property type="protein sequence ID" value="AGN01578"/>
        <property type="gene ID" value="L593_08165"/>
    </dbReference>
    <dbReference type="GeneID" id="16182327"/>
    <dbReference type="KEGG" id="sali:L593_08165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1675"/>
    <dbReference type="eggNOG" id="arCOG01888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057697_0_0_2"/>
    <dbReference type="OrthoDB" id="39022at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="361" mass="39904" checksum="D6CD9851F5D3804E" modified="2013-07-24" version="1">MDPRIREHAEILIDHSVGLEEGDNVVISAPPVAEDLVVALVEVVGDRGGKPLTLLGSDRVGRAYLKSAEEFETPEHTLAMVEESDVHISVRANENVTETSDVDPETNSAHTQAMMPVREERLSKQWNLTQFPAPANAQLAEMSTEAYENFVWDAITKDWEAQAAHQQQMVDRMDDADEVRIVSGDTTDVTMKLGDNPTINDDAEHNLPGGEVFTAPIPDSVEGEVLFDLPLYHQGREVEDAYLKFEGGEVVEHSAAKNEEVLTEVLETDDGARRLGELGIGMNRDIDRFTYNMLFDEKMGDTVHMAVGRAYGDTVAEGNEQNKSAVHVDMIVDMSEDSRIELDGEVVQQNGTFVFEDGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C7</accession>
    <name>R4W8C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08590"/>
    <dbReference type="EnsemblBacteria" id="AGN01663">
        <property type="protein sequence ID" value="AGN01663"/>
        <property type="gene ID" value="L593_08590"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08590"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1759"/>
    <dbReference type="eggNOG" id="arCOG07445">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736489_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027432">
        <property type="entry name" value="dGTP_triphosphohydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD_assoc" evidence="1">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16989" checksum="0DC820EA581E0D54" modified="2013-07-24" version="1">MSSELIERYLGRNSDTTFRIDPSIAGGLEIEESLIYEVKLLQFLCKYYVFENPALVAQQHGHTKLIKELYDTLYEASAENSMYADMIPDPFDEKISMLHEGELGYSDIDAGTIRARLVADVIASMTEQQAMQLYERVTGRSPGLVTDRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D4</accession>
    <name>R4W8D4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cas_Cas4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446572.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01678">
        <property type="protein sequence ID" value="AGN01678"/>
        <property type="gene ID" value="L593_08665"/>
    </dbReference>
    <dbReference type="GeneID" id="16182325"/>
    <dbReference type="KEGG" id="sali:L593_08665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1776"/>
    <dbReference type="eggNOG" id="arCOG00800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088481_0_0_2"/>
    <dbReference type="OrthoDB" id="84826at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="1">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="219" mass="24432" checksum="E167E241416DE003" modified="2013-07-24" version="1">MSVAFSDLRVAAYCPRKLYYRRREPDRSPPEVVTERRDLATCYPELLAADDATLRELPIEKPPPTYRRTLQRTRERLDCWPDVVDPIARNVLLTGKEARGIAHKLVGDPPRPAIVSPGDPPPTGVWEPHSVQAVAAAKALAWERQRPVESAIVEYPTHGVIRSVELTTRRKSQYRSALRAAAELDGPPSRIENDAKCEPCEYAESCGVRSRSLGSLLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N9</accession>
    <name>R4W8N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445678.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04165"/>
    <dbReference type="EnsemblBacteria" id="AGN00784">
        <property type="protein sequence ID" value="AGN00784"/>
        <property type="gene ID" value="L593_04165"/>
    </dbReference>
    <dbReference type="GeneID" id="16180852"/>
    <dbReference type="KEGG" id="sali:L593_04165"/>
    <dbReference type="eggNOG" id="arCOG03915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159082_2_1_2"/>
    <dbReference type="OrthoDB" id="114990at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="99" mass="10475" checksum="37F7B8DA268AA213" modified="2013-07-24" version="1">MSPHATAGTEVQFAIAIVKTLLLLTGGAVTFFAYRAYARTQDRSLGMLATGFGLITFGVLMAGFSSELLEQTLAVGVLVESLLVLAGMLVIAYSLYEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S2</accession>
    <name>R4W8S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exopolyphosphatase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446937.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10490"/>
    <dbReference type="EnsemblBacteria" id="AGN02043">
        <property type="protein sequence ID" value="AGN02043"/>
        <property type="gene ID" value="L593_10490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182486"/>
    <dbReference type="KEGG" id="sali:L593_10490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2162"/>
    <dbReference type="eggNOG" id="arCOG01566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_1_2"/>
    <dbReference type="OrthoDB" id="19570at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="149"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="4">
        <location>
            <begin position="347"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="498" mass="52470" checksum="0E125E63F104604E" modified="2013-07-24" version="1">MPTRVVLGCGPEYRVLLARLAAAGDLLVVVDDGAEAKWLTERDVPVVEADPTDPDVLRGLDLAPESVVVATGTPDETSRIAAAAREVFPNARLLSQPSVQREDGETAAAAGTTDPAGVVADRVLEYVASEAGHRALELRQTLRETEQPIAVLTHDNPDPDAIASAVALVEIAAAVGVEAEVCYFGTIAHQENRALVNLLDLDLRELEELDELEEYGGLALVDHARPGVNDQLPDGTHVDVVIDHHPTHGPDEAGFVDLRSGVGSTSTLLTEYFDRLGVELTEPVATALLYGLRVDTDDFTREVSGADFEAAATLVPNVDTSVLERVESPSVSEETMEVLAWAIERRQRHGAALTACVGELSDRDALAQAADRLLDLEGISTTLVFGIIDDTVFVSGRARGAGIDLGATLRSAFGQLGSAGGHADMAGAQLPVGMLVEADDSDPVAIVEEVLTNAFLEALETSRSTAAGGYALAGDGLSFLPDVRMDAPRLPELDDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U3</accession>
    <name>R4W8U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445828.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04925"/>
    <dbReference type="EnsemblBacteria" id="AGN00934">
        <property type="protein sequence ID" value="AGN00934"/>
        <property type="gene ID" value="L593_04925"/>
    </dbReference>
    <dbReference type="GeneID" id="16181196"/>
    <dbReference type="KEGG" id="sali:L593_04925"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1006"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088473_0_0_2"/>
    <dbReference type="OrthoDB" id="53692at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="286" mass="32141" checksum="4D9B591FA06A60D1" modified="2013-07-24" version="1">MRTEDERIELLQSLDLKEYEATALAHLLSAGRTTAPDVAEATGIPKARVYDVLASLGEQGYVKVIPGRPKEYQPKSPEAVLERAKENRRQAYEDYVGEVESLREDVLETFGPLFEQADEDVTPTAELFHVVDVGEPSETETRRLYNVAEETVYVITNSFAYFDAVEPAVRDALDRGVAVSVLLLDPAHLPEEKAEVQSAIVERISAEYPGVEYRFSEERLPWRGTFVDPGGDYESGQAIFLTEEPDVPNHRRQAAITENGSFVAGMKRYFDLVWEYESRDDVSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U4</accession>
    <name>R4W8U4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446987.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10740"/>
    <dbReference type="EnsemblBacteria" id="AGN02093">
        <property type="protein sequence ID" value="AGN02093"/>
        <property type="gene ID" value="L593_10740"/>
    </dbReference>
    <dbReference type="GeneID" id="16180045"/>
    <dbReference type="KEGG" id="sali:L593_10740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2214"/>
    <dbReference type="eggNOG" id="arCOG01038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_0_1_2"/>
    <dbReference type="OrthoDB" id="110798at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19937" checksum="98A68BBDF57B154B" modified="2013-07-24" version="1">MRVAVTGTPGTGKTSAVDALEGSDEGVPNGLEVVHLNEVIEPEGLYEELDEERDSLVVDFEAIADFLADREHVLIESHLAHHLDVDRVIVLRCAPEELERRLEQRGEDDPSRAESDASIAENAESEALDVILAEAVDRHGRDAVYEIETTDRTPSEVAGEIRAAILGDREPSAGTVDYTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y0</accession>
    <name>R4W8Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="12" type="ORF">L593_11165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447072.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11165"/>
    <dbReference type="EnsemblBacteria" id="AGN02178">
        <property type="protein sequence ID" value="AGN02178"/>
        <property type="gene ID" value="L593_11165"/>
    </dbReference>
    <dbReference type="GeneID" id="16181549"/>
    <dbReference type="KEGG" id="sali:L593_11165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2303"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OrthoDB" id="89943at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_S4e_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="11">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="9">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="266" mass="28676" checksum="555F49933E4259F5" modified="2013-07-24" version="1">MSNHQKRLSVPKSWPVERKTETFTVKADAGPHGEDGVPLVVLLRDVLGYVDSRKEARYALDAGSVRVNGDRVSDEGRPIGMFDILAFLEREEYYRVFPDEGGRLALSEIDEEAAGSKLGKVVGKRDIAGGDVQLTLHDGETLVVEAGADYAPKDSLVVDNEDGEIVAHFPYEEGELVTAVRGQHAGQIGELETIDVAAGSSPNRVVVDALDGETFETVEEYVVVIDENFVSDEDASDETDEADEATGDSDADADDESAEDEGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z4</accession>
    <name>R4W8Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445973.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05650"/>
    <dbReference type="EnsemblBacteria" id="AGN01079">
        <property type="protein sequence ID" value="AGN01079"/>
        <property type="gene ID" value="L593_05650"/>
    </dbReference>
    <dbReference type="GeneID" id="16181412"/>
    <dbReference type="KEGG" id="sali:L593_05650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1157"/>
    <dbReference type="eggNOG" id="arCOG06323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066582_0_0_2"/>
    <dbReference type="OrthoDB" id="117670at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="25110" checksum="1DCD889E364B3445" modified="2013-07-24" version="1">MEEAPRVREALRESLREIDPDPFRARLERTLEGRPLTPGILTVRTASAIDGAVASEAAAQRAAGVQLIYEGLRLTRRLVETEPWPPAGEGDPDVDVVAAEVLVASGLNQLAHTGVRDRVVEIIRRFGRTHSRDADGQPHEGDASDLDAGDSPLDVDDEPSLEADVVVLAIAAGADLAAQTVPPGLIEYARELAAEIDADPLPDGEPIDDVAETVERIVAAAESPAEDRSRSSTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W948</accession>
    <name>R4W948_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coenzyme F420 hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446078.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06175"/>
    <dbReference type="EnsemblBacteria" id="AGN01184">
        <property type="protein sequence ID" value="AGN01184"/>
        <property type="gene ID" value="L593_06175"/>
    </dbReference>
    <dbReference type="GeneID" id="16181649"/>
    <dbReference type="KEGG" id="sali:L593_06175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1261"/>
    <dbReference type="eggNOG" id="arCOG02650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037958_0_1_2"/>
    <dbReference type="OrthoDB" id="19205at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="615" mass="66767" checksum="F905303CEA4CB34E" modified="2013-07-24" version="1">MTNEATEEAKPTTGASERASGERSEPRAEQSEAPADAAPEIAEHPNEETEQLCHPAVPEVGENDDGHSVPRAEGIRTHRPASEHGTIPAEQIGPADPDGPVPAAPEDDHSHDHGHDHGDDGSEGRCGCGDTCGCSDDTGGQPAVAADGGATPSNVTPDGQLDLGEMTEPAEGVSQDIEHEDPPDERVGLPDGVDLDTPGYEIRDRMNDIETPDEKTWFMELDEAVIDEDRCIQCGTCVAACPSDSIGIGDDDLPELVKMCTGCSLCWDFCPRGGLRYERQWKLTGGDDNVKGAGDPITEFSATVQEDWRENAETAEPSRALAHDVRENAQDGGVVTSVLIHLLEAGEIHGALVATESEEAPWKAEAFLATTPEELIANAGSFYNQTMALGNVDFGQWEHKLPDVDPEDLSLALVGTPCEIEGIRALQDFEWDYAAHETGVRAIDYTIALMCTKNFNYERLLGELVEEERGIPIESIGKLDVLHGDLMVWDTDGEMVLQEEIEHFHDAALKGCDECADFTGFTADLTVGSVGSSDEYSSVIVRTEQGMKAWNLTKDDLDFHDLEDRSAIGKLQGWDKKQAFESLEREFDPDAPRFIDYTDHAEHYGTELNPHDAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9B2</accession>
    <name>R4W9B2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">L593_12945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447422.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12945"/>
    <dbReference type="EnsemblBacteria" id="AGN02528">
        <property type="protein sequence ID" value="AGN02528"/>
        <property type="gene ID" value="L593_12945"/>
    </dbReference>
    <dbReference type="GeneID" id="16180260"/>
    <dbReference type="KEGG" id="sali:L593_12945"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2654"/>
    <dbReference type="eggNOG" id="arCOG01719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030702_0_0_2"/>
    <dbReference type="OrthoDB" id="35861at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="482"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="628" mass="68237" checksum="9E0A22B2973EAF0B" modified="2013-07-24" version="1">MTAADDESLDYEALGLVAGLEIHQQLDTDTKLFCSCPTELREPEESDRRFTRYLHPTKSELGEIDEAALEESMVDREFEYLAFDSTCLVEEDDEPPQELDAEALDVALEIATLLDMTVVDQLHVMRKIVVDGSNTTGFQRTSKVADGGEISTPEGPVGIEDLMLEEESAQRIEETESGVRFGLDRLGIPLVEIGTQPDIRSPQQARDAAERIGMLLRSTGAVKRGLGTIRQDVNISIADGARVELKGVQSLDDIDDIVRNEVRRQKRLVEIAEELQDRDATVGEPKDVTDVFADTESGVISGALNAGGEVHGVRLAGFDGLVGAELQPDRRLGTELSDYAKRYGAGGIFHTDELPAYGVTEAEVEALRDAVDAETDDAVAIVAADPEIAEQSIEAAADRAEVAIRDVPEETRDAQQDATSSYLRPLPGAARMYPETDVPPVEPDPSEVETPELLTEKEERYVAEYELGAGLAEQVAYGEYMPLFETLVEDDDVDPTLAADTLESLLTGLRRDDVPTERLTDEHLRDAIGLVDAGEVPNEGLEDLLVALAENPDLTAADAVEQEDLGGVSEDEVREAVVEVVERNAEQVETEGMGAFSGLMGECMGALRGKADGDVVSEVLREEIQQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G6</accession>
    <name>R4W9G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446388.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07745"/>
    <dbReference type="EnsemblBacteria" id="AGN01494">
        <property type="protein sequence ID" value="AGN01494"/>
        <property type="gene ID" value="L593_07745"/>
    </dbReference>
    <dbReference type="GeneID" id="16182214"/>
    <dbReference type="KEGG" id="sali:L593_07745"/>
    <dbReference type="eggNOG" id="arCOG04583">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029501_2_1_2"/>
    <dbReference type="OrthoDB" id="67480at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="22874" checksum="DB43A3A989AD4B13" modified="2013-07-24" version="1">MDRSRAATQAVYDEIAAHFAETRRYPWPEVTEFLDAAPPGEFGLDVGCGNGRHLAPLADRVEHTIGLDLSTELLEIARERTNVDADLVAGDAATLPVRSDSIAVAVSIATLHHLPTRDLRVRSLDEIARVLTPDGQALVSAWSVAADRFDADAGFDAEIPWELPDGETVDRYYHVYDPDEFEADLAASDVRVLDVEVSSGNCYATVAKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J0</accession>
    <name>R4W9J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01569">
        <property type="protein sequence ID" value="AGN01569"/>
        <property type="gene ID" value="L593_08120"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1664"/>
    <dbReference type="eggNOG" id="arCOG11853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833195_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="33904" checksum="1EED0AD70D2BF39F" modified="2013-07-24" version="1">MRSLGLALIVLGAAVLVAPTLGFDSIDAERRVSADAAANPNAQLGLQQAYDGTQIQYVDGIFGDTVVNATVANVTNRVGNPLTVDARVASIDWSGGSDAVLEVSNDGDFSGQLATNGTVPIRLGCSQQVSGTATDATVGITVDGSGDPVSVQGATIAVQNVAFNCDGAGAGDGDPPDDPIPITDPRIDLQVVGQPAATQGFFGANSVVTYDLENTGDDPVAVTGIHIADASAGSRVRRGGDELTIPASSTGNLDQTDGLSIGANAPQYDLDQNATIAGGQTAGVELGQFRAGSYFWQQVDMRGESVTVVLMVEGLNVSGREDPVPVEMTLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L7</accession>
    <name>R4W9L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding ACT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446518.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08395"/>
    <dbReference type="EnsemblBacteria" id="AGN01624">
        <property type="protein sequence ID" value="AGN01624"/>
        <property type="gene ID" value="L593_08395"/>
    </dbReference>
    <dbReference type="GeneID" id="16180884"/>
    <dbReference type="KEGG" id="sali:L593_08395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1720"/>
    <dbReference type="eggNOG" id="arCOG02316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100860_0_0_2"/>
    <dbReference type="OrthoDB" id="71317at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="167" mass="18604" checksum="ED4B4E2EEF8029FA" modified="2013-07-24" version="1">MFDEILEKFEGSPSQQAVIRLLLERGFSVNDEGRVVSGGIEIPNTGIAREIDVDRRVVDSTTDAILEDEELRRIFQNISQVPSLMDLAPVLDLTVLTVEVAEAEEHGIVAEISKLLAERELSIRQIITEDPEFTDEARCYVIIDGEAPGELLNVISDLPFVRSVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P4</accession>
    <name>R4W9P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">H/ACA RNA-protein complex component Gar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447747.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14585"/>
    <dbReference type="EnsemblBacteria" id="AGN02853">
        <property type="protein sequence ID" value="AGN02853"/>
        <property type="gene ID" value="L593_14585"/>
    </dbReference>
    <dbReference type="GeneID" id="16181340"/>
    <dbReference type="KEGG" id="sali:L593_14585"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165884_3_1_2"/>
    <dbReference type="OrthoDB" id="115856at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="73" mass="7845" checksum="E4B7C22ED513DB60" modified="2013-07-24" version="1">MERLGTTHRIAQGLAIVKVDDVPDIGTEVVDDQLDEVGSVVDVFGPVSEPYAAVSPRSDRSLAPLIGQPLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q3</accession>
    <name>R4W9Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447777.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14745"/>
    <dbReference type="EnsemblBacteria" id="AGN02883">
        <property type="protein sequence ID" value="AGN02883"/>
        <property type="gene ID" value="L593_14745"/>
    </dbReference>
    <dbReference type="GeneID" id="16181448"/>
    <dbReference type="KEGG" id="sali:L593_14745"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3011"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102056_0_0_2"/>
    <dbReference type="OrthoDB" id="81179at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="210" mass="22724" checksum="774E8257F82E89E6" modified="2013-07-24" version="1">MYDLDDVLPDAEIGPGTNLLISGPPMTGKRRVAFQILARGTDHGEGVIVVSTKDGAEKVFDEYGRFASGLEDSPVGVVDCVTKQQGAGDVEDSARVKYASSPVDMTGIGIKLSEFLEEFYDGRGVQRNRILLHSISTLLMYSNLQTVFRFLHVFTGRIQSADALGLYVIDSTAHDDQTMNTLKQLFDGVIEVDEDDAGEQSISTAGIQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Q7</accession>
    <name>R4W9Q7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447797.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02903">
        <property type="protein sequence ID" value="AGN02903"/>
        <property type="gene ID" value="L593_14845"/>
    </dbReference>
    <dbReference type="GeneID" id="16181299"/>
    <dbReference type="KEGG" id="sali:L593_14845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3032"/>
    <dbReference type="eggNOG" id="arCOG06187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822850_0_0_2"/>
    <dbReference type="OrthoDB" id="44989at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="37528" checksum="9340FF2C60A51D49" modified="2013-07-24" version="1">MAKGLDVGTMNILSAQQDGNDTVFVQQRNSFVEIDYSDMAEQMLSRSEVLHIRKDDKVYVVGDDALNFANIFNRETRRPMQAGILSSDEKSAIPMMKLIIEQVIGEPDRPGEKLYFSTPADPIDTDLSTLYHQKTIESFLGDMGYDAEPINEGMSVIYSELADNSFTGLGISFGAGMTNVCLSYYAVPVMKFSVARGGDWIDEQAAQATGTPVDKVTSIKEEDFELDFETDVGGVEGALSIYYENLLDYVIDLIVEEVDEEDVEEGLDVPVVVTGGTSSPDGFEALFRDHLEDANIPFSISGVSHADEPLYSVARGALVAARSDEQETEGSADAEAEGEAAAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y2</accession>
    <name>R4W9Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446893.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10270"/>
    <dbReference type="EnsemblBacteria" id="AGN01999">
        <property type="protein sequence ID" value="AGN01999"/>
        <property type="gene ID" value="L593_10270"/>
    </dbReference>
    <dbReference type="GeneID" id="16182810"/>
    <dbReference type="KEGG" id="sali:L593_10270"/>
    <dbReference type="eggNOG" id="arCOG04563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_3_2"/>
    <dbReference type="OrthoDB" id="54562at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043854">
        <property type="entry name" value="DUF5816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19133">
        <property type="entry name" value="DUF5816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="242" mass="26515" checksum="EB1843047569DFCB" modified="2013-07-24" version="1">MHVRQASPADGDPVRELVERSMLSSYSLGPGTITAAVGEWFGTDALAEKRDDGDRAVFVAERDDAIVGVVDAAYVPETGTGDVLWLHVHPDYRGEGIGRRLFEAATDWLADAGADHVRGLVLSNNADGNAFYRELGFERVGEREVEIDGTPYTEHVYHGEGRERVTVLEDDGREVYVDLEDASRGSLGPFFTVFADADKTERYGFQCGHCDTLATAMDSMGRVECSACGNTRKPTRWDAAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA24</accession>
    <name>R4WA24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447103.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02209">
        <property type="protein sequence ID" value="AGN02209"/>
        <property type="gene ID" value="L593_11320"/>
    </dbReference>
    <dbReference type="GeneID" id="16182363"/>
    <dbReference type="KEGG" id="sali:L593_11320"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_5_1_2"/>
    <dbReference type="OrthoDB" id="117536at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="12805" checksum="93E858C6FB734851" modified="2013-07-24" version="1">MSDGPFPPDATPLGRQFDALKNPVRRRILVGLLDTDDAGAVGDGPIDRDLPEHRLIELHHVHLPRLAESGYVEWDDSPLEVRRGPAFEEIEPLLELLDEHRNAFVGQWPDSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA36</accession>
    <name>R4WA36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447163.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11630"/>
    <dbReference type="EnsemblBacteria" id="AGN02269">
        <property type="protein sequence ID" value="AGN02269"/>
        <property type="gene ID" value="L593_11630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180572"/>
    <dbReference type="KEGG" id="sali:L593_11630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2397"/>
    <dbReference type="eggNOG" id="arCOG04153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142666_1_0_2"/>
    <dbReference type="OrthoDB" id="127641at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="116" mass="13004" checksum="63976DF671C45C63" modified="2013-07-24" version="1">MSATAAETELSEDELAGLELVRETGGIHQSEFWKELDVSSRKGSRIVESLDEKGLVDREEAVYQGHNTYFIAPVARDLDFSLLMAGDMLSPFIGEEEIDPQSDAFSQWIMNLAYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA50</accession>
    <name>R4WA50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447233.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11980"/>
    <dbReference type="EnsemblBacteria" id="AGN02339">
        <property type="protein sequence ID" value="AGN02339"/>
        <property type="gene ID" value="L593_11980"/>
    </dbReference>
    <dbReference type="GeneID" id="16180980"/>
    <dbReference type="KEGG" id="sali:L593_11980"/>
    <dbReference type="eggNOG" id="arCOG01822">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134827_0_0_2"/>
    <dbReference type="OrthoDB" id="108228at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="154" mass="15962" checksum="CB7473B5D4695138" modified="2013-07-24" version="1">MASVSISHLVIFIASLLVAATVAGALVTGVDRISGSVTDRSLDTSEEVRTDLTIISDAGSDAVYNESGGNGTVTVLVKNTGSLNLDATADQVDVLVDGAYVGNGDVTVTSLEGEPLDWRTGSVVRIEIATTLDAGDHRVQVTANGDEEVLRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA55</accession>
    <name>R4WA55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide/dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447258.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12105"/>
    <dbReference type="EnsemblBacteria" id="AGN02364">
        <property type="protein sequence ID" value="AGN02364"/>
        <property type="gene ID" value="L593_12105"/>
    </dbReference>
    <dbReference type="GeneID" id="16182626"/>
    <dbReference type="KEGG" id="sali:L593_12105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2491"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="456" mass="49800" checksum="654F99DE86100C3F" modified="2013-07-24" version="1">MALLEISDLTVEFYTEEGVVTAVDELSYHVERGETFGVVGESGAGKSVSSLSLMQLIDDPGRIVGGSIRFDNPDTTERLEGEYPERVIDVDELRTEYDLSEVVRDLAQTGADGADLTGNDAHEGMSPTDVPASEYDFHDVLERGHAVDLGLIDEHDFIVHDGSDSYVELMRAPEPAVRSIRGREIAMIFQDAQTALNPVYPVGEQVAEPIRHHLDYSESEAKERAIQLLDEVGIPDAEARYSDYPHEFSGGMQQRAVIAMALSCDPDLLIADEPTTALDVTIEAQILEQIQDLAAEFDTAVQFITHDLGVIAEICDRVMVMYGGKPVEKASVEELYYDPKHPYTVGLMSSIPRVGDQSERLQTIPGTMPDLVELPPGCSFHPRCPFAEEACTRKEPALVDPSTGEEVDEMADRGAACLEYTGDLEGGLDYEVKVEDADVDLENQAAVDAQGGDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA59</accession>
    <name>R4WA59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447278.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12205"/>
    <dbReference type="EnsemblBacteria" id="AGN02384">
        <property type="protein sequence ID" value="AGN02384"/>
        <property type="gene ID" value="L593_12205"/>
    </dbReference>
    <dbReference type="GeneID" id="16182807"/>
    <dbReference type="KEGG" id="sali:L593_12205"/>
    <dbReference type="HOGENOM" id="CLU_2257485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="103" mass="10819" checksum="164E4F3F0531E5F6" modified="2013-07-24" version="1">MIEVMDIAERTSWYKQRRAQAYAFPLEALEQGDAIGAAGESPAGSDGPSTGVGDGEEQQGLGTVGEPAVESGQDGVKQLGSGRRYGRPMRMVARKAEGDSFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA63</accession>
    <name>R4WA63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_12325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447298.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12325"/>
    <dbReference type="EnsemblBacteria" id="AGN02404">
        <property type="protein sequence ID" value="AGN02404"/>
        <property type="gene ID" value="L593_12325"/>
    </dbReference>
    <dbReference type="GeneID" id="16180622"/>
    <dbReference type="KEGG" id="sali:L593_12325"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2535"/>
    <dbReference type="eggNOG" id="arCOG14674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033791_0_0_2"/>
    <dbReference type="OrthoDB" id="61627at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CelD_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="597" mass="65902" checksum="7698D55AD5D676C6" modified="2013-07-24" version="1">MDILVDQLGYGPDEAKRVILQGNADDDPGAVRVEDAQTGEVVTTAEPEYAGHVHDWKDWEYWTADVSAVDAEGEYVVSVTHPERTDDIVARSRPFEVGDDLFVQRALSDVVRYFRVERCTGIYDRYDREATFVGDREDRVDVSGGWYDASGDVSKYLSHLSYANFMNPQQIPLVVWSLLDARDRLSTATNTGRLGGDVDERDAIGFDALEEACFGADFLVRAQDEAGYFYMTVFDTWTSDPEERDVCAYEGMEGTKTEDYEAGYRQGGGVAIAALARASRLGHAGEFGPETYYESAVTGFDHLEANNEAYLDDGVENVIDDYCALLAATELAGAAAERGEAEAADRFAAAAAERARSLLDRQTDDGWFHADDGDRPFFHASDEGLPIVALVRYLDVVVDEQPGEAPADDDLAEEIADAITRYWEWELELTDDVVNPFGYARQYAQAVDEDEPAARFFFPHENESGYWWQGENARLASLAAAAHSSLAVLDGPELTESLPAFARDQLSWILGRNPYDTCMLEGIGNDPVPFVPGAPNTAGGIVNGITAGFDDETDIAFRPPAYADDQTNNWRWTEQWLPHAAWFLVAGSWEAATEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAE6</accession>
    <name>R4WAE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447713.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14400"/>
    <dbReference type="EnsemblBacteria" id="AGN02819">
        <property type="protein sequence ID" value="AGN02819"/>
        <property type="gene ID" value="L593_14400"/>
    </dbReference>
    <dbReference type="GeneID" id="16181239"/>
    <dbReference type="KEGG" id="sali:L593_14400"/>
    <dbReference type="HOGENOM" id="CLU_1529294_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="17396" checksum="CA2C3D3ADC2520B1" modified="2013-07-24" version="1">MVLNNPDRTAALQLLAVLLMAVALVGSLIVVGAASAQEQVGNSTVPGVDAGENRTVTVEIHWNASADAANDSASVAIEHVTSDGTVNATTTDAVPADPGTWTYNQTTVSPAVDVDHFDVNVTATNASVVDDVQISDDAAAGGGAVSGSDDGSTGILGGIILLAVLVGGALYVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF5</accession>
    <name>R4WAF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transporters inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14640"/>
    <dbReference type="EnsemblBacteria" id="AGN02864">
        <property type="protein sequence ID" value="AGN02864"/>
        <property type="gene ID" value="L593_14640"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2989"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="33308" checksum="5E7C857D8C3B8376" modified="2013-07-24" version="1">MTFIAPLDASPELKERIAADLGLDQPIHVQYADYIVGVLQADFGYSFQRGLPASEVVWLRVPATVELAIAASVVAFVLSIPLGVVAATRRHSPADYGATLFSLLGISTPNFWLGIMLILVLSVQLDLFPTSQRPIGFLEAWSNLIVIHTGDPSVSFPMKLGSFGDDLGTWLWHIALPAITLGTYFTALITRLTRSGMLDELGKEYVTASRAKGLPETLVRYRHALRNTLIPIITVLGLQLGTLIGGAVITEQVFAWPGLGSLLIDAINDRDWPVIQASLIVIGVSFVIINIVVDALYGYLNPKVGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG0</accession>
    <name>R4WAG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447783.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14775"/>
    <dbReference type="EnsemblBacteria" id="AGN02889">
        <property type="protein sequence ID" value="AGN02889"/>
        <property type="gene ID" value="L593_14775"/>
    </dbReference>
    <dbReference type="GeneID" id="16181471"/>
    <dbReference type="KEGG" id="sali:L593_14775"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3017"/>
    <dbReference type="eggNOG" id="arCOG04411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114819_0_0_2"/>
    <dbReference type="OrthoDB" id="81883at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014518">
        <property type="entry name" value="UCP022079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09920">
        <property type="entry name" value="DUF2150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022079">
        <property type="entry name" value="UCP022079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="194" mass="21321" checksum="44ED1AB82F8A9AEE" modified="2013-07-24" version="1">MSEPPQEFYSEDRWQNWIDRLSNEDIDPEDEDSARLLLNLQDDAALAVAKIVTAYEDEQLGEDEAMEEIADIRDVVLDDPGLDDEETAILVDGVQTSLMCVFYASEEYIVGGPAEDADVAEYLRAAADAEAEEDLDAALGFAAQAGTLVIDGEELDMSVAEDLEYGLVTEWINGLDSLQSAMSDPEVVEEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG9</accession>
    <name>R4WAG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15000"/>
    <dbReference type="EnsemblBacteria" id="AGN02934">
        <property type="protein sequence ID" value="AGN02934"/>
        <property type="gene ID" value="L593_15000"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_15000"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3063"/>
    <dbReference type="eggNOG" id="arCOG02771">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030480_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="445" mass="46991" checksum="CB87ECE5BDD0F8F8" modified="2013-07-24" version="1">MAVALLASIDVVAASNVSAGLGSRGDVSVPTWLYAITGGGVIGASGLMSMLVTDRELLDSLHGKRVEFGVPNGLGALVSLAGGVIGVLALIGIVVVGFQGPQIGQVNAGVLLVFVGGRAGLTIVAYLVGNPWPAIDPWRHIASVLPTGYREYPERFGTWPAVGVLLVLIWLEVVLPVTSEPALLASLVLGYTAFTLAGAVAFGETDWFRHADPISVWYRYYGAVAPLQRTADGVALRPYGARLRDGDVFEDRSGVGFAILLVAELTFSGVIATEPGSDVVQSIVDAGIPSAIVYALFLPGLFGLFFGAYLLAARDSRERAQTFLSTRYLGYRFAGPLLAIAAGYHFAHYGGFLLSLFPTLTTVAQAPFSTLNPSQIVLPSWFGHVEALAILVGHVLAVWLAHGTAIDTFPGRVQAIRSQYPFILVMVAFTIASLWIISLPTISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSK3</accession>
    <name>R4VSK3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acVLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445079.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01160"/>
    <dbReference type="EnsemblBacteria" id="AGN00185">
        <property type="protein sequence ID" value="AGN00185"/>
        <property type="gene ID" value="L593_01160"/>
    </dbReference>
    <dbReference type="GeneID" id="16181589"/>
    <dbReference type="KEGG" id="sali:L593_01160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.236"/>
    <dbReference type="eggNOG" id="arCOG01743">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051790_0_0_2"/>
    <dbReference type="OrthoDB" id="67956at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040783">
        <property type="entry name" value="VLRF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18859">
        <property type="entry name" value="acVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acVLRF1" evidence="2">
        <location>
            <begin position="179"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="33227" checksum="C5B290E5F18D1BAA" modified="2013-07-24" version="1">MIDRLLGGGRIEELEAELEEAREERERAEAQLEAEERRRAEAVTARQEAQERVNELEDRIAQLEGTVERLEGDEADLSFRGRRNLDRRATARILDRLDSVEAPPDAAMTAVVDDHVPEDAREAFGERSALVERAAPCVAVTDEDGLLSAALRPPVLPEPGVTWAESFDLDRSSFLPTGTFAVALVRSDLFALGEYRGDERLAFEGFESDVKGDHSKGGFSQGRFERRRDAQIEEHLEDVQAALADRDAETLYLTGDRSALDALADEVDARASAPVDATGKPEAALEEAFADFWRTTLYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT47</accession>
    <name>R4VT47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445269.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02120"/>
    <dbReference type="EnsemblBacteria" id="AGN00375">
        <property type="protein sequence ID" value="AGN00375"/>
        <property type="gene ID" value="L593_02120"/>
    </dbReference>
    <dbReference type="GeneID" id="16182359"/>
    <dbReference type="KEGG" id="sali:L593_02120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.430"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054903_1_0_2"/>
    <dbReference type="OrthoDB" id="71077at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="310" mass="33211" checksum="503E07BE6A89F1FB" modified="2013-07-24" version="1">MSLRLPEEIVAEQFVPTARTMLARELDERGLTQQAIADRLGITQAAVSNHLNGQVDVAAPIADDPRMAATVEEIADGFAEGSMDEVDALGELVALVQAFEDRGPICELHEQAMPALEGLGCDLCVRGRDEAVQAERDALAAVREASRRLGASQEMVTMVPNVGTNVATAIPGATEPTDVAAVPGRLIRMRGRIEVPANPEFGASRNVATAILAATTVDPEMRGAINLALDEDLLAAARERGIDPIEFDPEYENRRERLVSLFEERGSVPRLCYHRGAFGVEPVCYVFGETAVEAVDLAIELRNAVAGQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT93</accession>
    <name>R4VT93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase subunit PaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaA</name>
        <name evidence="2" type="ORF">L593_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445324.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02395"/>
    <dbReference type="EnsemblBacteria" id="AGN00430">
        <property type="protein sequence ID" value="AGN00430"/>
        <property type="gene ID" value="L593_02395"/>
    </dbReference>
    <dbReference type="GeneID" id="16180185"/>
    <dbReference type="KEGG" id="sali:L593_02395"/>
    <dbReference type="eggNOG" id="arCOG04786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879733_0_0_2"/>
    <dbReference type="OrthoDB" id="27991at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="314" mass="36017" checksum="6DD2EB9744536610" modified="2013-07-24" version="1">MDIETVKERAGPRAFGPSDDMPEEYRKAATRMLQFHANSEIMGAYLERPFIRKAPSLERKMAFSAKVQDEIGHGQLLYRAAESLGVKTREEMLEELANGEGKFLNCFHYPMTDWVETPMIAFFVDGAAMRRQATLKRSSWEPYAHAMDKVCFEEGFHVKHGESILAELMNGSRAEQRRTQEAFEEWWPRILQFFGPTDEKSTHHDFASEVGLKFQSNDDLRNAFLNAYLPKARKYGLEIPDEPRIRERDDGTFEVTEDDLDWDEFFEVSKNQYGGSEVQIGKRHDTQEAVEWVRGALEETERAAMADGAPAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTF8</accession>
    <name>R4VTF8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Box A-binding protein</fullName>
            <shortName evidence="6">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA sequence-binding protein</fullName>
            <shortName evidence="6">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tbp</name>
        <name evidence="8" type="ORF">L593_02770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445399.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02770"/>
    <dbReference type="EnsemblBacteria" id="AGN00505">
        <property type="protein sequence ID" value="AGN00505"/>
        <property type="gene ID" value="L593_02770"/>
    </dbReference>
    <dbReference type="GeneID" id="16180334"/>
    <dbReference type="KEGG" id="sali:L593_02770"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.561"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OrthoDB" id="83880at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="186" mass="20319" checksum="71FE400055FDA3B7" modified="2013-07-24" version="1">MSDPKETINIENVVASTGIGQELDLQSVAMDLEGADYDPEQFPGLVYRTQEPKSAALIFRSGKIVCTGAKSTDDVHESLRIVFDKLRDLKIDVNDDPEIVVQNIVTSADLGRNLNLNAIAIGLGLENIEYEPEQFPGLVYRLDEPEVVALLFGSGKLVITGGKQPEDAEHAVDEIVTRLEDLGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTR9</accession>
    <name>R4VTR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03395"/>
    <dbReference type="EnsemblBacteria" id="AGN00630">
        <property type="protein sequence ID" value="AGN00630"/>
        <property type="gene ID" value="L593_03395"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.687"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="494" mass="50862" checksum="9B032F361A4ABA30" modified="2013-07-24" version="1">MVDRGRVASVWRRVLSLSWPMMVEQVTRTGMRTTDVFVTALFSPIAVAAIGLADLYARLPLRIGLGLGTGAIALSSQDTGAGAEATRDEAISQALLVGALAGIPFVLFGFFLGEPAIAVLGEWADPDEVAEVADLGGTYLAIIFATAPARHVSLIAARSLQGTGDTRTPMYVNVVSNVLNVALSLILGLGLLGAPRLEVVGVGLATAFGNVFTATVMVGVLALGVRDAGLRRPTEFVIAKQLLVVSAPKIAEGLIATVIEFPFNALLLYFGTPVNAGYQIGRRVYQQVTSPLSRGLHVAASVVVGQSLGAGKPDEARFDGWATTALGVLLVGSIGLGLVVAAGPIVGLFTDDAATASHALAFVRAYGLSAPFLAAFVLLAGALQGASETRTPFIARTSGLLVVYLGVSFVGGLVLGYGPLAVYVAVAAWNVWGFAIVCWGFARGDWAERAASMMADRGSTAGDAVVADGESDENGNDEMDAPADRGGDETVDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VU52</accession>
    <name>R4VU52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase-like complex subunit CD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_03845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445614.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03845"/>
    <dbReference type="EnsemblBacteria" id="AGN00720">
        <property type="protein sequence ID" value="AGN00720"/>
        <property type="gene ID" value="L593_03845"/>
    </dbReference>
    <dbReference type="GeneID" id="16180652"/>
    <dbReference type="KEGG" id="sali:L593_03845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.780"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_2_2"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="6">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="313"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="563" mass="63866" checksum="41189F2011A5CA64" modified="2013-07-24" version="1">MSTGEEQSEEPGEQAIEPTEAKLTELRSLLGEHVLDTEEHLNAPGIVIRPDDVQAVLSTLKEEAGYDHCSLVTAQQYDDRYESIYHLKKYADPTDEVSVVVPTARDDPVSESAAPVYTTADWHEREAYDLVGIEYEDHPDLRRILLPETWQGHPLRDDYDQDRPQIVTLRENANPLEPDHRGDAEEGESDTMFLNIGPHHPATHGVLHLKTVLDGEQVVDVESDIGYLHRCEEQMCQQGTYRHQIMPYPDRWDYISAGLLNEWAYARAAEDLADIEVPEYAQVIRTMSAELCRIASHMLAMATFALDINGDFTATFMWAIREREKAQSILEDLTGQRMMFNYFRLGGVAWDLPSPTEDFFEKTRDFLDGLPGATQEFHDLLTNNEVFQLRTIDTGVIDPETAKDFGTTGPVARGSGIDYDLRRDDPYGYYDELEWDVITEDGCDNYARLLVRMREVEQSAKIIDQCVDLLEDWPDEEREIQANVPRTLKPERDTEIYRAVEGAKGELGIYIRADGTDKPGRFKIRSPCFSNLQSLPAMAEGEYIPDLVAALGSLDIVLGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUE6</accession>
    <name>R4VUE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04395"/>
    <dbReference type="EnsemblBacteria" id="AGN00830">
        <property type="protein sequence ID" value="AGN00830"/>
        <property type="gene ID" value="L593_04395"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.894"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="305" mass="32548" checksum="0813C5D4E2313511" modified="2013-07-24" version="1">MPLQRRNVFARSHATVDRATALDDWPSADGGRAEAGAMKLALAQLAIEDGAIDANRERAVDAVAEAAAAGADLVALPEIVTAGYFAFDAYERAAEPVEGPTIEALRPAAIEHEVAVLAGTIVEDLAATASVETPAESGLANTAVLLDADGAIQLVYRKHHLFGYDSREAELLVPGERLDTASVQGIDVGVTTCYDLRFPELYRDLLEQGVELILVPSAWPEPRVEHWQTLPRARAIENQLYVAAVNGAAVDRDGPSLLGRSTVFDPWGTPISASGPEPAIVTATVDPDRVAEVREDFPALDDRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUG8</accession>
    <name>R4VUG8_9EURY</name>
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        <submittedName>
            <fullName evidence="4">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445749.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04520"/>
    <dbReference type="EnsemblBacteria" id="AGN00855">
        <property type="protein sequence ID" value="AGN00855"/>
        <property type="gene ID" value="L593_04520"/>
    </dbReference>
    <dbReference type="GeneID" id="16180972"/>
    <dbReference type="KEGG" id="sali:L593_04520"/>
    <dbReference type="eggNOG" id="arCOG02327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465133_0_0_2"/>
    <dbReference type="OrthoDB" id="88736at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PAS_4" evidence="3">
        <location>
            <begin position="237"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="586" mass="60426" checksum="C75CE2DF7A6C10E2" modified="2013-07-24" version="1">MIASAIPLDAVAAAVAVLLSVGLTLHLLHRRSRPAAGPLLGVALALTAASALHLATTAPVADALSRVLPIGVRVDGWWVIQGATVGTVAGGLWALFALAYVGRGRRLFVAVAGAVAVLSTAAITVTFLAASRGRTAAHVDALALCYLATAILAAVGIGLLMLASVRQNAFPVAEPLLLSAGAVALLSGVQLAQVIGHRWLFPGSLAVASAALLVPVVRYPLFDTLPAARVAGRDRVFDALSAGVIVVDEADRVRDLNDRAASLFDLEPDAVQGAALDEVLGFDLDLETLATAREGVRTTTADHRTLALTTTPIRGSGARQYGHVLVCSDVTDRRVREEQLALLRRFVVDVVGTRMETAATTATAAADQCDAGTSPTAAADRIWENATAVTRLVASARAVERGIDTGDGRASDGPTSTTTSNGEAIPARDLRATVRHAAASAEMDVSPPPSIDPADGPLRTTLPTPLVRTILETVLDDVARRDPSGVDLRVAASERPSIEVLATFETAPETDLPSIPIARLAIERAGGRVSTSTPGAASLRLSMELPGTGAAESRPPAATATRSTPSVTRSRGRSAAPDDDPDGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUK9</accession>
    <name>R4VUK9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">XapX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445799.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00905">
        <property type="protein sequence ID" value="AGN00905"/>
        <property type="gene ID" value="L593_04780"/>
    </dbReference>
    <dbReference type="GeneID" id="16181097"/>
    <dbReference type="KEGG" id="sali:L593_04780"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.977"/>
    <dbReference type="eggNOG" id="arCOG06356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171061_3_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020017">
        <property type="entry name" value="XapX_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03510">
        <property type="entry name" value="XapX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="6646" checksum="DAAA384995B44D38" modified="2013-07-24" version="1">MDLPLVALALLTGFLTGALFAFVQVPIPAPPELPGLLGIVGIYLGYTVVDWAGVGIDLLGRLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUL8</accession>
    <name>R4VUL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445809.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04830"/>
    <dbReference type="EnsemblBacteria" id="AGN00915">
        <property type="protein sequence ID" value="AGN00915"/>
        <property type="gene ID" value="L593_04830"/>
    </dbReference>
    <dbReference type="GeneID" id="16181111"/>
    <dbReference type="KEGG" id="sali:L593_04830"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.987"/>
    <dbReference type="eggNOG" id="arCOG06189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121888_3_0_2"/>
    <dbReference type="OrthoDB" id="118003at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="15765" checksum="6533FC3400C24031" modified="2013-07-24" version="1">MNFDEFTGEVQHRLELPGTGEAVRATRATMMTLGQRIPADNAEDLAASLPMEVKWYLTDAVDEHGERFDWSTFLDRVAEIEQADPADAAYHARVVVDLVRECVPESDFQQLRDQLPEDEDRGNWGKLFEVVDSGGWSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV25</accession>
    <name>R4VV25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_00855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00855"/>
    <dbReference type="EnsemblBacteria" id="AGN00126">
        <property type="protein sequence ID" value="AGN00126"/>
        <property type="gene ID" value="L593_00855"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00855"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.175"/>
    <dbReference type="eggNOG" id="arCOG02007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP006402_thioredoxin"/>
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    </dbReference>
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        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="607" mass="64499" checksum="AAA92D27F8FAB8F6" modified="2013-07-24" version="1">MTEDPDGTEEPAPGSRAAERAAASDPAPGVPTWPPGGHVEWRPWGQATFDEAANAGVPVLLSLTATWSEECRQMDAETYGEPRVAADIDDGFVPVRADVDRNPRVANRYAMGGVPSTAFLTPEGEVLNAAGPLTASGMRGAIEGVRRTWSEQGSTAGRVPRALADEEPPGAPLDASIEGHLLETLRENFDEQAGGWGTGAKFPMPRAIEFALKRDREMALRTLDAISSNLEDEHAGGFHRSAANRNWSSVSYEKLLDSNAALIRAFAAAYRYTGEESYRRSAERGVEFLTTTLWTDDAPGDRGAFAASQAAGPGADYYALEPSERERAEAPFVDETVLADWNALGIDALLSVAAVTDDETAEAFARRALATLVGSLIEEGETVHYRSPAAEDSDGERGLLLDTARTIRTLVTARGVLGPDPAVDAFDGEETASGPVALARELVDTAIDERRPGQTFVDGPIGDVGLLDRPLRPLDANVELAGALLDLAEVTGVDRYESIARETAEAFAGAHERFGPQAAAFGTVAGRLLRGTVRIDLTAAVGSDLHRAALRLADHEAIVVPAIGDAGEPIDRDVDYEPDAAYVVADGERSAPAFHPEELSERVASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVI4</accession>
    <name>R4VVI4_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_06280</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01205">
        <property type="protein sequence ID" value="AGN01205"/>
        <property type="gene ID" value="L593_06280"/>
    </dbReference>
    <dbReference type="GeneID" id="16181681"/>
    <dbReference type="KEGG" id="sali:L593_06280"/>
    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711009_0_0_2"/>
    <dbReference type="OrthoDB" id="33909at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="388" mass="43124" checksum="37A18A0F22831A2A" modified="2013-07-24" version="1">MTDAALPVTERAVEQFVEEYLTSIGGEIQKRDRTWSVTLPDAAPTELDIEGTDLVVASDPEEVPDGALAIAPDSDFVNRLLEEAGKLAPVGSFSLTAGTFDLQNRLPSWITGGPAQVLETSFSPYYDRRALCVLFDVGIETVSQFQSEELRAVAVDAKNAEPLPRLAETYLEVTGADSPPLEEGKELDAQALETTLDAAKEQIEQEIAPTVEEIRERATRAADVELEEYREVVRQRRQELDDEIDRLDERIAEISKEIDSADEQHDRVEALRTRKQLRADREELAAERDELVEKIEAGFPEQRREIRDRHALTVRVQPSILTTVTYERGDIEYQLEIDGARTTVTCPYAVGIGVMEAPTCSRCGRTLDGESALTIEDGEVVGNSCCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVS2</accession>
    <name>R4VVS2_9EURY</name>
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        <submittedName>
            <fullName evidence="5">DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">L593_02025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00356">
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        <property type="gene ID" value="L593_02025"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02280">
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    </dbReference>
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    <dbReference type="OrthoDB" id="95668at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
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        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="24593" checksum="F70DD774DB7736D7" modified="2013-07-24" version="1">MATIIRGTVPATEFALSHTLETVPAAEFECERIVRSGEHSIMPLLWVRADDAEAVEDALAADPTVEAVNRLSSFDDEHLYEMQWIDHVRLLLHMLTNGGATVLDAYGRDGRWQLRVLYPNRDHFSTTHEFADEHGMTFDVESIREMDGEPAGRFGLTDAQHEALTAAAKAGYYEVPREVTLEELADDLGVSHQALSEQLRRGTCALLEDTLLIGMTNQEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWI4</accession>
    <name>R4VWI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08300"/>
    <dbReference type="EnsemblBacteria" id="AGN01605">
        <property type="protein sequence ID" value="AGN01605"/>
        <property type="gene ID" value="L593_08300"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08300"/>
    <dbReference type="eggNOG" id="arCOG07989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191095_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="9784" checksum="725D49AAD0A932CD" modified="2013-07-24" version="1">MSLGEGIYTEGGERVGTIRGFDASGFYVTLKAGVDAPTTEEHSTVGEVGEINLMWRCWQCGETGRIDEMPDHCPSCGSPAEELYYWTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWK9</accession>
    <name>R4VWK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445560.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03575"/>
    <dbReference type="EnsemblBacteria" id="AGN00666">
        <property type="protein sequence ID" value="AGN00666"/>
        <property type="gene ID" value="L593_03575"/>
    </dbReference>
    <dbReference type="GeneID" id="16180672"/>
    <dbReference type="KEGG" id="sali:L593_03575"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.726"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_2_2_2"/>
    <dbReference type="OrthoDB" id="59290at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="409" mass="42765" checksum="3912EA38CAE34661" modified="2013-07-24" version="1">MGRPSTFALRYYAYRVTSAAGFTAPIWYLYLYANGLSYFEVAVVNAVWWSGLLLFELPTGYVGDRIGRRESLLLGTGTVTVATLAMIPASTLPAFAVVFAVWAAGQTFRSGADDAWLYDGLDKDDSDATFLHLRSRGTALALVTTGATALVGGWLAEANIEYTFLAAAIVSALGLPILWTFPASRDPDDETLGTFEALPVLREELGRPGVRSFVLLIGLFTGVHWGVNFFVQPVSVDLGVSRTGLGVLYAGFTGLGALGSYRAEWIAERIGIDTWFRAIPVGLAALLVAVAFLPALAIPAFVAIRTAKSTATPLAADWLNDRIGSVGRATVLSAQGMVATALTVPFELGAGSVAELLGPLSTVALFGAVLGSLTVGILALGRPFARSVGTDSSCSENPADGGGIAGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX16</accession>
    <name>R4VX16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445700.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04275"/>
    <dbReference type="EnsemblBacteria" id="AGN00806">
        <property type="protein sequence ID" value="AGN00806"/>
        <property type="gene ID" value="L593_04275"/>
    </dbReference>
    <dbReference type="GeneID" id="16180887"/>
    <dbReference type="KEGG" id="sali:L593_04275"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.870"/>
    <dbReference type="HOGENOM" id="CLU_2662529_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="7896" checksum="6F143A5B0974D084" modified="2013-07-24" version="1">MRAATRLWLLRIAALVLTLPLWFLLFALAVSLDAGPVVGLLVVFVPLGLLAAGIALLVRGLRAGDRASDGSTERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX34</accession>
    <name>R4VX34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01780">
        <property type="protein sequence ID" value="AGN01780"/>
        <property type="gene ID" value="L593_09175"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09175"/>
    <dbReference type="HOGENOM" id="CLU_856904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="324" mass="35635" checksum="40739540946EC4EF" modified="2013-07-24" version="1">MQQQPTQQSQQYRQQYAQQPQQQAQQFPQQQPSQQQAPQQSQQQMPQQQTPQQQSPQQQIPQQPVQHVPQGQLPQQPSQQGIPQQQIPQQQSAQQVPQQHGASTQGALHQQAPQQQLPQQGLGQQQPFQQQYPRQQSSTQHVTGGQAPQQGSQHQGIGQSGQQPASQSPQQGYQQLQQGQPRQQPSQYPQESQQQMGRQSGQLQTQRYGRQRAQPTGVGSQPSQIGQQGTAGFAQQSQQPGAAQQYGGQQMAGGGTGMESMQPFLEQANDVAQRFAELGQAFQQAQLAPIASWLQATGMLQPTTGTERTGGFGQPKTGQWAQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX56</accession>
    <name>R4VX56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445740.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04475"/>
    <dbReference type="EnsemblBacteria" id="AGN00846">
        <property type="protein sequence ID" value="AGN00846"/>
        <property type="gene ID" value="L593_04475"/>
    </dbReference>
    <dbReference type="GeneID" id="16180993"/>
    <dbReference type="KEGG" id="sali:L593_04475"/>
    <dbReference type="eggNOG" id="arCOG02703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080641_0_0_2"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="225" mass="25331" checksum="60A8EC393B774AC5" modified="2013-07-24" version="1">MTTLPEPDVSNETVVATYHRLAAVYDWFVTPLEMGTRQRALELLAIERGDHVVEVGCGPGHALVALAERVGPDGYVVGLDAAAGMVRLARRRAIRRGATAQVDVCLGDARSLPFRSNVVDVAFIEDTLELFADDEMRTVLAELERVLRPDGRLCVVTMERAGAEDDPFVRAYDWFFERVPGYDRFGCRPIYAARMLEEAGFEVERRERLRRAWVWPVEVLIARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXB5</accession>
    <name>R4VXB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446774.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09675"/>
    <dbReference type="EnsemblBacteria" id="AGN01880">
        <property type="protein sequence ID" value="AGN01880"/>
        <property type="gene ID" value="L593_09675"/>
    </dbReference>
    <dbReference type="GeneID" id="16182783"/>
    <dbReference type="KEGG" id="sali:L593_09675"/>
    <dbReference type="eggNOG" id="arCOG10154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127668_0_0_2"/>
    <dbReference type="OrthoDB" id="108627at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="15468" checksum="07F5EE2AFA3B037F" modified="2013-07-24" version="1">MATDRAPESGATLDDETVTALHEVELGYEWLQRANGHLLQFHHATGHGMDHLAAAEEHLRAAGHADLANAIRDDLLPRGVVDDDRWSYDLVEEFQHGILTDVDAFEREARDELAAGDRHVAERLQERRWKERRQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXP5</accession>
    <name>R4VXP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_10425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446924.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10425"/>
    <dbReference type="EnsemblBacteria" id="AGN02030">
        <property type="protein sequence ID" value="AGN02030"/>
        <property type="gene ID" value="L593_10425"/>
    </dbReference>
    <dbReference type="GeneID" id="16182530"/>
    <dbReference type="KEGG" id="sali:L593_10425"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2149"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OrthoDB" id="86536at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="111"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="351" mass="39105" checksum="D0454DF7FEB16457" modified="2013-07-24" version="1">MASDDLRTTLERVGERFNLGEYGTDAYLAVLEHGELTASEISERTDIPQPRVYDTVRSLSDRGLVELRESRPMKVVAIDPAEAFEELESSLDRMIAELEARYTAPARETEAVSLVRSRATILRYVEEVIESAEYELALSLTPSLLERFETQLGRAVDHGVSVDLIVTPGAEAPDPDEYDYTTVCTNARTRRGITTPVIAVADGEYSVYATQDAIRDDRERYGVIFNRSALGFLLSGFYGTVLWTTSEELISDGTDRSFPRIYASIRRCVKDLQTVEGPLYATVRGRDVLTGEPRVVRGRVIEITFEHTEEVAGLTVETEDGTVTIGGQVATLEDIESHELWIGKEEPPEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYA4</accession>
    <name>R4VYA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent endonuclease of the OLD family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01201">
        <property type="protein sequence ID" value="AGN01201"/>
        <property type="gene ID" value="L593_06260"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1279"/>
    <dbReference type="eggNOG" id="arCOG03235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029682_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="569" mass="64252" checksum="2DBE7721D6C147EE" modified="2013-07-24" version="1">MTHMQLSELHVENFKSIEETHIDSVDDLSVLVGKNDAGKSSVLEAVKMFLEEKGKPERDQFHMECDDDIVITAFFEDVPAELADCLNDSIELTNGRLKISRRWEYPEDSRSMADTYLGPDEEQLGAGTLVGDHESDGKRDTRQYLWKLLPDPIYIPAERNIAEETKFKSDTLIDQLLTPLLEENDDIRSKRNELESELNDGVDGLQTDIEDRLTDHVDSISQLELVTGDINLGKAFSPSIQVTDEFSEISVPIAERGSGVGSLLVLSLVETYRERQVGEGYVMLFEEPGNWLHPEAKRRMLGALKRISENGGQVMLSTHSPIFIDRRGHGDVFLVQRHEGKTSVREIEENYLTIVEELGARNSDILQSDFVVYVEGITDVQMVEIVADNYLNETERARITIQHLGGGGNIQQCSLSDLSEINRTFGFLLDSDKSDPEDTEKDYIDDLREENESIEPEVVIEVLEKREIENYFTPEGVNEALRLEVDSDFIGDFEDIPDKLGAEVRRHHAGESVPPQADRTCDECGRIEHPGKGYHKSKGKDVVAAMYDQGQCIEPVEDFFDEVKRIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYD3</accession>
    <name>R4VYD3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446125.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06420"/>
    <dbReference type="EnsemblBacteria" id="AGN01231">
        <property type="protein sequence ID" value="AGN01231"/>
        <property type="gene ID" value="L593_06420"/>
    </dbReference>
    <dbReference type="GeneID" id="16181733"/>
    <dbReference type="KEGG" id="sali:L593_06420"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1308"/>
    <dbReference type="eggNOG" id="arCOG00373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409187_0_0_2"/>
    <dbReference type="OrthoDB" id="12724at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="655" mass="74550" checksum="F83EF10EDA447938" modified="2013-07-24" version="1">MSSQGASNAYYDVEVENIGGIEESHLRFAPGITILSGRNATNRTSFLQAIMAALGSDRASLKADAEAGTVSLTVDGETYDRELWREGDAVLTDGEPYLEEPDIADLFAFLLEDNEARQAVEQNGDLREVIMRPVDTDAIHAEIDELTAEKERLDDEIADLDEAKRRLPELEAERSRLEDAIEEKRDALADAEAEIDEADGGIEETRETKDELEGKLAELRAVRSEREDVRYDLETERESLASLRTEREDLEAELASLPEMPAGEHGEIEARLEALRDRKQSISSDLSQLQTIVQFNEELLDGADNDLVEAVTEGDAADGAESRSPTDRLVDDAEQLTCWTCGNTVERAHVESVVDGIEELRREKLAERSDVDEEIGDLQSEKQELERQQQRHEKLQRTLDRRTEEIEDTEERIESLEARSEELADEIGSLEAEIEALEREEYSELLELHTEANQLEFEIDRLEDELAATTGEIESIEERLDRRADLEDERADVVARLRDRRTQIDRTEQRAVESFNHHMDDVLNALEYENVERVWIEQREREVREGRRTVARSTFELHVVRETESGEAYEDTLEHLSESEREVIGLVFALAGHLTHEVYEEMPLMLLDSLEALDSERIEALVDYLEEYVDSLVIALLEEDAAVFEDAEDVTICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYK9</accession>
    <name>R4VYK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12010"/>
    <dbReference type="EnsemblBacteria" id="AGN02345">
        <property type="protein sequence ID" value="AGN02345"/>
        <property type="gene ID" value="L593_12010"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2471"/>
    <dbReference type="eggNOG" id="arCOG01783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048140_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="30129" checksum="E7F400503AEA83F4" modified="2013-07-24" version="1">MPARREAFPVREFSAEYLTNTRRGMWADSRATLADLSLAERDRVLDVGCGTGELTRVLAEETTGEVYGVDADPALLTVAREYSPVVAGDALQLPFADDAMDLVVCQALLINLPDPAAAVEEFARVASDAVAAIEPDNSDVTVESSVEQEATLTAEARAAYRRGVPTDVALGGAGTRAAFEDAGLADVRTTRYDHVRTIEPPYAEADLEAVRRTASGAGLAGDRETLLAGGLSEAAYDDLRERWRAVGRAAIEQVRDDRYRRREVVPFYVTVGTVPPGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ48</accession>
    <name>R4VZ48_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.130</ecNumber>
            <ecNumber evidence="2">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysK</name>
        <name evidence="3" type="ORF">L593_07905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="2"/>
    <dbReference type="EC" id="3.5.1.132" evidence="2"/>
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        <property type="protein sequence ID" value="AGN01526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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        <property type="protein sequence ID" value="AGN01526"/>
        <property type="gene ID" value="L593_07905"/>
    </dbReference>
    <dbReference type="GeneID" id="16182233"/>
    <dbReference type="KEGG" id="sali:L593_07905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1619"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_2"/>
    <dbReference type="OrthoDB" id="40270at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ArgE/DapE_CS"/>
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        <property type="entry name" value="LysK"/>
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        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="372" mass="39359" checksum="900BA72FD8C51423" modified="2013-07-24" version="1">MATSTTHEVDADAAEELLLDLVETPSPSGEEDAAAERLIAFFEAHDREVFRDEVGNVRAPADDSVLLTSHVDTVPGEIPVRVEDDPADEVLSDRDAADEDTRVLWGRGSVDATGPLAAMAVAAVETGVSFVGVMQEETDSAGAHFLVEDRDAPGAVVNGEPSGWDGITLGYRGLIAGTYVATSESGHTSRPEPNAIEHATSWWAAVREAVSEVGGDEFDPVFEQVTAKPVSIDGGTSEDGLSVEATMDVQLRIPPALDAGSLRELADGELDLGTVNWGTPIPPVMESPRTPVARALRGAIRRSEGDPRLLRKTGTSDMNVFAREWDCPMATYGPGDSDLDHAPDERLPLAEYHRAIAVLTDAAADLAEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ87</accession>
    <name>R4VZ87_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13230"/>
    <dbReference type="EnsemblBacteria" id="AGN02585">
        <property type="protein sequence ID" value="AGN02585"/>
        <property type="gene ID" value="L593_13230"/>
    </dbReference>
    <dbReference type="GeneID" id="16180482"/>
    <dbReference type="KEGG" id="sali:L593_13230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2707"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074745_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="253" mass="27302" checksum="21C68BBE36C62738" modified="2013-07-24" version="1">MDSLEAELERARDLDVAVLADAIESIGFECTRCGGCCKGETDEPHTATVFPDEVRRLQASAVAADGDDVDDDDGDQTEYDWRDVARPMPYGLTDGPDGLEGETFEWALQTDACGDCRFYEEPSDASGAAGQDRSDDERGADQPGNGYCTVHEDRPLICETYPFSVALGGTSQPMGEAVDAEGIVRAHECEGLGRDIARTDAEELAMALRERAIRELEEAIAVRDAYEPMPAGPGEIVVHDSEGPKRSDGTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ91</accession>
    <name>R4VZ91_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Glycine cleavage system protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02590.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_020447484.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13255"/>
    <dbReference type="EnsemblBacteria" id="AGN02590">
        <property type="protein sequence ID" value="AGN02590"/>
        <property type="gene ID" value="L593_13255"/>
    </dbReference>
    <dbReference type="GeneID" id="16180491"/>
    <dbReference type="KEGG" id="sali:L593_13255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2712"/>
    <dbReference type="eggNOG" id="arCOG00757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_3_2"/>
    <dbReference type="OrthoDB" id="40466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="3">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="375" mass="39922" checksum="6E4116A5AC6E60A9" modified="2013-07-24" version="1">MTVLRSVHEAHGATFTERGGRSVVLDYGRPERTVTAVRNVAGVTEAAYGIVSVTGDDRVDYVDNAVTNAVPTAEGDGSYALLLDPDGKIRTDMYVYHAGERLLVFVPPGEAESLAAEWTDKTFIEDVNFEVATAEFGVFGVHGPKATEKVASVFTNGTPPDERLTFDRGQFDDVGVTVLRTDAPTGEEGYEVVCAADSAEKVFDVLVNQGLNAAPFGWKTWDTLTLEAGTPLFASELDGRLPNVVGVRNALDFEKGCYVGQEVVSRIENRGRPPERLVGIQFDAEAVPEAGAAVMDGDAAVGELTRVMESPTLDATIAMAVVAADLDGGFEPDAESTEENRALSVRVAGEAVAATIVTLPFVDGSDRSARVPRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZF6</accession>
    <name>R4VZF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446530.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08455"/>
    <dbReference type="EnsemblBacteria" id="AGN01636">
        <property type="protein sequence ID" value="AGN01636"/>
        <property type="gene ID" value="L593_08455"/>
    </dbReference>
    <dbReference type="GeneID" id="16182369"/>
    <dbReference type="KEGG" id="sali:L593_08455"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1732"/>
    <dbReference type="HOGENOM" id="CLU_2010185_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13084" checksum="137200ABFF1C9E32" modified="2013-07-24" version="1">MQRRRFLSAATAATTAAMAGCSGLLGGDGGGKSAPEQTVEDLYAAIDAGNAEEARSYIHPDGPLAENPAVAGFGDAHIAIESTTLVEKTDSRATVEYVLVVNDEELTNEHELRKHEGEWLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZW9</accession>
    <name>R4VZW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09105"/>
    <dbReference type="EnsemblBacteria" id="AGN01766">
        <property type="protein sequence ID" value="AGN01766"/>
        <property type="gene ID" value="L593_09105"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1867"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="42325" checksum="BD17635DDFF94392" modified="2013-07-24" version="1">MYPTVTTLVVCLDRTDDVGATTGIQTPVAGWEAVQALVTDVGLADPEDASVNSILEALRITRELRDDGENAVVAVVSGTPDSMVTADRTVAGQLDDLVAEYDPDSAIVVTDSAEDERLVPIVESRVPVDSVDRVVVRQARDLESTYYLMKQFLADEELRQTTLVPLGTALLVFPALAVFAGPAVAAATIATVIGLFLLYKGLGVDELLARAARQAQNALYSGQVSVVTYVVAAGLTLVGVFAGALGISAQPETEGVLLPVMRFAYDAVPWLAMAALTASTGRLLDEVLRDDGIRTSYLNLPFVALAVALVVRGFSAYFLEEAGTLGPLEIPRLELGVLTVEPFVLEAGQRLALYVVSGVVVSLIGVRIAAYLGGGDFPGVDLEAAPDGGDGTADRDGDAESETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZY2</accession>
    <name>R4VZY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447709.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14380"/>
    <dbReference type="EnsemblBacteria" id="AGN02815">
        <property type="protein sequence ID" value="AGN02815"/>
        <property type="gene ID" value="L593_14380"/>
    </dbReference>
    <dbReference type="GeneID" id="16182643"/>
    <dbReference type="KEGG" id="sali:L593_14380"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2943"/>
    <dbReference type="eggNOG" id="arCOG08166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734900_0_0_2"/>
    <dbReference type="OrthoDB" id="76020at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="394" mass="43787" checksum="803DCB8556370A09" modified="2013-07-24" version="1">MSGDGTDPHALHVTAEAREHQEGYSARENREIADHGGVIRDEQISRALAVRAIHYDPTNAERPGAMPGESKDLQKHREIRKIEGTETFRRAMENGDTPSVKHLVGDTSHQPDISGIKAIGAVDELIEGPAPVIVVLGEPGAGKTDFACLLAQRWRALQNEQSLVGTNIQTLQEANEWVDETGDVRDGWIPNHPTLVEWVKQDGSPLEHSQRPKLFIGDEFSSAASGSGEQGQKVRKKMGPTVFKIRKYGGALIYIGHDESSIHPMLWRLGKIVKKVSKKKAVVADRISGGQLKDVETTIEGVPPTDWRYNTKEESDWHWSRPSGAGQENGLDEEQAVKPVSMWTMVQCREQGMSPRATAEFVPYSHETVRNWLKEYDNDGEKRDWVDNVEAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W041</accession>
    <name>R4W041_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="7" type="ORF">L593_09505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446740.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09505"/>
    <dbReference type="EnsemblBacteria" id="AGN01846">
        <property type="protein sequence ID" value="AGN01846"/>
        <property type="gene ID" value="L593_09505"/>
    </dbReference>
    <dbReference type="GeneID" id="16182737"/>
    <dbReference type="KEGG" id="sali:L593_09505"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1957"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OrthoDB" id="75288at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="20574" checksum="DC5A17F7B84D3429" modified="2013-07-24" version="1">MAFEDLLEDPVIQKYLHELVGPKGMPVAAAPPDGEVTDEELAEELDMELNDVRRALFILYENDLATYRRLRDEDSGWLTYLWTFQYDNIPENLEEELYRLHDALEEREEYERNHEFYLCEVCSIRFEFGEAMEFGFECPECGSPLETMDNDLLIQAMYERIGSLREELHIEGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0L7</accession>
    <name>R4W0L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446975.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10680"/>
    <dbReference type="EnsemblBacteria" id="AGN02081">
        <property type="protein sequence ID" value="AGN02081"/>
        <property type="gene ID" value="L593_10680"/>
    </dbReference>
    <dbReference type="GeneID" id="16182342"/>
    <dbReference type="KEGG" id="sali:L593_10680"/>
    <dbReference type="eggNOG" id="arCOG00524">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_0_0_2"/>
    <dbReference type="OrthoDB" id="82365at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="178" mass="18996" checksum="5F5ACA6CD62AFE63" modified="2013-07-24" version="1">MASVLMLYGTSEGQTAAVAERMAGVVEATGHDVALLNAKHLPADFSLADYDAAMIGGSIHMGSQPEAIRRLVDEAVETLNAMPTAFFSVSLSAAGDEEGQADAEGLIHDFLDETGFEPDRTLSVAGALKYSEYGLLTKFMMKRIARKEGGDTDTSRDWEYTDWDSVEAFAAAFASSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0T2</accession>
    <name>R4W0T2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl3p</name>
        <name evidence="6" type="synonym">rpl3</name>
        <name evidence="8" type="ORF">L593_11105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447060.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11105"/>
    <dbReference type="EnsemblBacteria" id="AGN02166">
        <property type="protein sequence ID" value="AGN02166"/>
        <property type="gene ID" value="L593_11105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180558"/>
    <dbReference type="KEGG" id="sali:L593_11105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2291"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OrthoDB" id="31722at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="337" mass="37000" checksum="79B0BDD49F4E03B8" modified="2013-07-24" version="1">MPQPSRPRKGSMGFGPRKRAASEVPRFNSWPDADGQPTLQGFAGYKAGMSHVVVINDQSGSPREGMEETVPVTVVETPPMYAVALRAYEDTPYGLRPTTEVWTDDARPELERALDVPEGHDFEAQAEELRELAENGEISELRAITHTSPDELEGVPRTTPDVMETRIGGGSIADRVDHGVDLVTEGGEHSMTDVFRAGEYLDVAGVTKGKGTQGPVKRWGVQKRKGKHARQGWRRRIGNLGPWNPSRVRSTVPQQGQTGYHQRTELNKRLVDAGDDEVTPEGGFVNYGEVEGNYALVKGSLPGPDKRLLRFRPAVRPGDQPRLDPEVRHVSTASNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W154</accession>
    <name>R4W154_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447185.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11740"/>
    <dbReference type="EnsemblBacteria" id="AGN02291">
        <property type="protein sequence ID" value="AGN02291"/>
        <property type="gene ID" value="L593_11740"/>
    </dbReference>
    <dbReference type="GeneID" id="16181209"/>
    <dbReference type="KEGG" id="sali:L593_11740"/>
    <dbReference type="eggNOG" id="ENOG502N5XI">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191133_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="108" mass="11112" checksum="0CF96CC24841F994" modified="2013-07-24" version="1">MDALQTNWTKPTLSESSVVLVGLLFAVVGLTFQDSVGVSSLLLALGIGLVVAGTVYLTVEGSAAVRLSLTFLALVALPLLFFGGLVRLLGVLGIGAVLVGALYSRRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W176</accession>
    <name>R4W176_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dual specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_11890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447215.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11890"/>
    <dbReference type="EnsemblBacteria" id="AGN02321">
        <property type="protein sequence ID" value="AGN02321"/>
        <property type="gene ID" value="L593_11890"/>
    </dbReference>
    <dbReference type="GeneID" id="16181998"/>
    <dbReference type="KEGG" id="sali:L593_11890"/>
    <dbReference type="eggNOG" id="arCOG03413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736348_0_0_2"/>
    <dbReference type="OrthoDB" id="88409at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="3">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="168" mass="18642" checksum="9D42784146E425A7" modified="2013-07-24" version="1">MASQDDPRIEFRIDGRELEGPHVRPFGCHPEASIVRQIGDRPLYLGNCHAADPAYCDRAFDAVLTVAKDPAPATTHHRPMPDSREATWEQFRSAADAACECYREEGDLLVHCKAGISRSTAVVAATVAVEERRHLSEAYDVVRAHRPYAVSHPQIRKLAAYYVAAYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1R8</accession>
    <name>R4W1R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonuclease/rho motif-related TRAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447480.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13235"/>
    <dbReference type="EnsemblBacteria" id="AGN02586">
        <property type="protein sequence ID" value="AGN02586"/>
        <property type="gene ID" value="L593_13235"/>
    </dbReference>
    <dbReference type="GeneID" id="16180494"/>
    <dbReference type="KEGG" id="sali:L593_13235"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2708"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121271_0_0_2"/>
    <dbReference type="OrthoDB" id="110514at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="135" mass="14537" checksum="C8D769D1F081BF95" modified="2013-07-24" version="1">MQISEKLLCLFSAEIESDGDRYVVEVPKRELETGSIEDGETYRVALIAGDEDESPAARDSSAPAADVASDQPQPPVEVGETRYVEIEDIGKQGDGIARVERGYVIIVPGAEVGERVKVEVSEVKSNFAVGEIIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W241</accession>
    <name>R4W241_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447600.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13835"/>
    <dbReference type="EnsemblBacteria" id="AGN02706">
        <property type="protein sequence ID" value="AGN02706"/>
        <property type="gene ID" value="L593_13835"/>
    </dbReference>
    <dbReference type="GeneID" id="16180869"/>
    <dbReference type="KEGG" id="sali:L593_13835"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2831"/>
    <dbReference type="eggNOG" id="arCOG01067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_2_2"/>
    <dbReference type="OrthoDB" id="29466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="380" mass="39839" checksum="1EEE477BA2E7C884" modified="2013-07-24" version="1">MRVLVLGGGYAGVTLTRKLERRLPDEHEIVLIDEDGQQVLQHELHRVVRRPQLAADIAVDLGTVLDRARLRVGTVDAIRPDDRAVVVEGETLEYDACAVAIGAAPSTAVEGTTEHGLPLKSLDDARSIHERATDVLDGTDGQIVVGGAGLSGIQVAGELAVLADRAAPDDGRATITVLEQEREVAPGFDAPFQSAIHSALESRGIEVRTDATIDRATADAVDLVRGESVPHDLLVWTGGITGQAAFDGDRPLVDARLRLGDRTFGLGDAVRVVDRDGQAVPATAQAAVREADTVATNVKRVLEGGTTFEPRLERFTFESPGWVVSIGNGAVAQVGPTVVTGTAAVAMKASVGVGYLSSVGALRDAVDLVNEELGLAVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H1</accession>
    <name>R4W2H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">L593_14760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447780.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14760"/>
    <dbReference type="EnsemblBacteria" id="AGN02886">
        <property type="protein sequence ID" value="AGN02886"/>
        <property type="gene ID" value="L593_14760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181455"/>
    <dbReference type="KEGG" id="sali:L593_14760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3014"/>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OrthoDB" id="102360at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="259" mass="27320" checksum="C30C50985522BC73" modified="2013-07-24" version="1">MLTFVGLGLYDEDSITRAGEAAIADADAVFAEFYTSKLLGATVEDLESHHDVDIDVRDRAGVEQDPEPILEAAESGDAVFLTAGDTMIATTHVDLRLRAASRGIETRVVHGVTAQSAASSLTGLQNYRFGPATTLPFPDSHGADGLPASVTDTIEDNRDRGLHTLVFLDIKAAQDRFMTADRAAALLAAAYGDLLGVVVARAGSPEPLVVADSIESLADRTFGEPLHLLVVPGDLHAMEADALAEFGGAPNALLPDRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2K4</accession>
    <name>R4W2K4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_14985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02931">
        <property type="protein sequence ID" value="AGN02931"/>
        <property type="gene ID" value="L593_14985"/>
    </dbReference>
    <dbReference type="GeneID" id="16181620"/>
    <dbReference type="KEGG" id="sali:L593_14985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3060"/>
    <dbReference type="eggNOG" id="arCOG00065">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="OrthoDB" id="24071at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="45"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="429" mass="47045" checksum="C2A6B741B7BBB56C" modified="2013-07-24" version="1">MEAQESQPLDVAAIREDFPILERRVGSEVTPGTIGKDDPDGQQIVYLDNAATTQKPQSVVDAISEYYTRYNANVHRGLHHLSQEASIAYELAHDRVAEFIGASGEREEIVFTSNTTEAENLVAYAWGLDELGPGDEIVLSEMEHHSSLVTWQQIAKKTGATVRYIRVGGDGRLDMEHAKELIGPDTAMVSIVHVSNTLGTINPVSTLADLAHEQDALIFVDGAQAVPTRPVDVEAIDADFYAFSGHKLLGPTGIGVLYGKKHLLEEMDPFLFGGEMITKVTFEDATWNDLPWKFEAGTPRIAQGIGLDAAIDYLDDLGMENVREHEELIAEYAYDRLDEFDDVTLFGPDPGPDRAGLVAFALDDVHAHDVASIMNDHAVAIRAGHHCTQPLHQKLGVPATARASFYVYNTREEVDALVDAIDDARQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W385</accession>
    <name>R4W385_9EURY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445266.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02105"/>
    <dbReference type="EnsemblBacteria" id="AGN00372">
        <property type="protein sequence ID" value="AGN00372"/>
        <property type="gene ID" value="L593_02105"/>
    </dbReference>
    <dbReference type="GeneID" id="16180075"/>
    <dbReference type="KEGG" id="sali:L593_02105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.428"/>
    <dbReference type="eggNOG" id="arCOG04663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098519_0_0_2"/>
    <dbReference type="OrthoDB" id="125800at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="215" mass="23462" checksum="EE823E3C90E8C598" modified="2013-07-24" version="1">MSNVGLEDLLDEGRRNAAASWFLVAIAAATWIGVVVTVGVLWSVFALVIVVLSVLPPIVFRSRYVMLPWEVLAMASLPLLGIAVGAQRLSGPLFTYFAIAAVALVIVVELDSFTSIRMSPGFAIVLVVAATMAAAAAWALLQWYAAIFLDRTYDMTNDELMIEFTYASLAGLGAGLLFRTYFRRRVVATDRVPESLREELRDELIPTTDGEVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3S6</accession>
    <name>R4W3S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GAF/PAS/PAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_03755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445596.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03755"/>
    <dbReference type="EnsemblBacteria" id="AGN00702">
        <property type="protein sequence ID" value="AGN00702"/>
        <property type="gene ID" value="L593_03755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181529"/>
    <dbReference type="KEGG" id="sali:L593_03755"/>
    <dbReference type="eggNOG" id="arCOG02278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010057_3_0_2"/>
    <dbReference type="OrthoDB" id="56183at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="676" mass="72273" checksum="D04DE257D46F5047" modified="2013-07-24" version="1">MAGDQGSTEPLERLLSGLLGDEGVAVLDDVTTGDVTFEAVTGVAYEGREVIKEVLSESMAAYDEYDLEIEWTVADGDRIVASTRTTAKSRRGILGIPPPEDTRTIETIFDGRLEDGKIAYLRQTFDTRQMMPVAVRRGRGAVLEQMRDGVIVLDDRELVVDANAAAFELLGVEREDAMGESIEDVLGLEDYEIAPSTDPTEYERDGRIYELRSSPIFAEADEPVGHTVVARDVTERERRTRQLAEQRDELERLADLNSILRGVNQALVAATTRQEIDRTVCDRLAAPDLYDAAVVGDVQTWAGDAERWTVAGSRDPTGLRVPELDRPPAARSDGGASVRRAYEPTVESGAAPSSANASATQSSADGAADDSDPADSGVASGDSESSAAPDPADTWTVVPLVYGTTVYGALGLCTDREAVGQRERDVLVELGETIGHAINALETRRLLSADATVALKLDSKDSSDPLVAATANADGDAAMAVDGLVPAGEGQNVAYLAIEGERPASVASSFESEAAGDVRCVRGEGDGADWLLEWSMTGDSPLAALVESGGHLDDASATNGRATYQVEVASDADVRSLVDRLRCRFPEVHLVSKSERSGPPSSPESVVVPERTDLTQRQREALEVAYRSGYFGWPRDSTAEEVADALDVAPSTLHSHLRKAEAAVFDSFFGDLHADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W404</accession>
    <name>R4W404_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445726.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04405"/>
    <dbReference type="EnsemblBacteria" id="AGN00832">
        <property type="protein sequence ID" value="AGN00832"/>
        <property type="gene ID" value="L593_04405"/>
    </dbReference>
    <dbReference type="GeneID" id="16180927"/>
    <dbReference type="KEGG" id="sali:L593_04405"/>
    <dbReference type="eggNOG" id="arCOG02021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113899_0_0_2"/>
    <dbReference type="OrthoDB" id="43730at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="261" mass="28598" checksum="F0502B734F78D893" modified="2013-07-24" version="1">MNRRSFLANGLGAVATTSLTAGCLFRDDEQQQPEDGSAQGGPGYALNPRDVEAPDVDPSTFERLEVRGQQVPLVPIDVAYPWYLRQETRIVDARSLTAYERSHVAGAVLSPAPMGYRNDDPTSDWPNADRIVTYCTCPHHLSSSRAAGLLEQGFENVYALDEGFGPWYDRGYPVASANEVQQTIGEARAITGRVDSAYAGEFVRLRHEPTGQREPAEIAADGRFEVTFRFVDVDADSVLTLETPAWTRTATLAELTSGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W418</accession>
    <name>R4W418_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445751.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04530"/>
    <dbReference type="EnsemblBacteria" id="AGN00857">
        <property type="protein sequence ID" value="AGN00857"/>
        <property type="gene ID" value="L593_04530"/>
    </dbReference>
    <dbReference type="GeneID" id="16180952"/>
    <dbReference type="KEGG" id="sali:L593_04530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.923"/>
    <dbReference type="eggNOG" id="arCOG02599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114810_0_0_2"/>
    <dbReference type="OrthoDB" id="63240at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="198" mass="22064" checksum="36BE5CA86D28E99E" modified="2013-07-24" version="1">MDDQQDADTGAADRPRVLIVDDEREVADAYALRLRDVADVETAYGGQAALDTVADGTFDVVLLDRHMPGTSGDEVLDELQDAAFRGRVVMVTAIDPGFDVLDMPFDDYLCKPVDREDLVAAVDQQCSILGHELLGDYFGTEAKRRVIAAEFPEEERRSHERYGELETRVEALRRRVGRLLDDPSDLLSSFDDVGRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4D1</accession>
    <name>R4W4D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sec-independent periplasmic protein translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445951.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05540"/>
    <dbReference type="EnsemblBacteria" id="AGN01057">
        <property type="protein sequence ID" value="AGN01057"/>
        <property type="gene ID" value="L593_05540"/>
    </dbReference>
    <dbReference type="GeneID" id="58789338"/>
    <dbReference type="KEGG" id="sali:L593_05540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1132"/>
    <dbReference type="eggNOG" id="arCOG04736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359694_0_0_2"/>
    <dbReference type="OrthoDB" id="13074at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="908" mass="97315" checksum="063161FB88C409D4" modified="2013-07-24" version="1">MSVVDEDTARAVNAGRETIGGVLSEAQRELKKVFLVFVFAFLGTILALRWWIWDYLEAVTKAQMNESVAQEVDIIARTPFDVILMQVKIGVIVGIVLASVVGLYLARKAILGRIEDTGVNVTTGKVYGFVGLSLGLAVVGMVYAYAVFFPLMFKILAEQAYAAGAKPSYGIVRFTEFLLLLTISFALAAQLPLVMGVLSYGEIVPYETFRDKWRYAVLGIFVFGAVFSPPDPFTQIMWAIPLITLYAFSLGVAKVVTNVHRGGVRNSPVEPGTFRRKGYLVVGAFVLSGGATALALYTGHAEVIGEAVLEQLPRSASIPFLGEVTFPTTVERGGPTVWLRSGLVMGVLGGAVALAYALVAVLRMPVVPRAYVGVEEEEDPEAVDVASLDVEGVRRAPLAAFADLSESEAVDIAGEAMEAGDEEKGRLVLERWEDAQQAADGDGADGDSEDAVDLRGLDAAGVADAPDSAFAALTEEQAVEIAGAAMENGDEEKGRLVLQRWQAAEDVDEPPVTGDPANLDLRELDAGGVEAAPTEAFAAISEDEAIDIAGEAMEAGDEEKGQLVLQRWDEINEAGTAAPNGGEGDPNAVATADVEAGAGAETTEQSAATDEEGGAFDDLFSDTAGGMLGAFADEERDEDEIGGYMYDIGFILDSMRSRMFVIVAVFIGVFTATFAYLYTVGIKQIMDVFISQVPNEALAPGQRATDATDVIIALHPVEVLIFIVKFSGVLAILVTTPVILYYAWPALQQRGLAPGSGDRRAFLMWGYVLLMGTLTGAVVGFFGVAPTVISYLVTDAVQSGMVVSYRIKSLLWIVFFMTIGFGFFLNIPIGMILLHLSDLVYFESMRKYWRHFVLVTFVVAALITPGGILTMLVFAIPVAVAYVLGLLLLWLLTAPWRLFGRGRASRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4E3</accession>
    <name>R4W4E3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01077">
        <property type="protein sequence ID" value="AGN01077"/>
        <property type="gene ID" value="L593_05640"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05640"/>
    <dbReference type="eggNOG" id="arCOG08980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159738_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="10628" checksum="2A73B10B79BE527E" modified="2013-07-24" version="1">MGIAPNDHDVQTVQTDDLRSLSVAADDLSPSLRIVAAIADTIGTDPATMAPLFRTVDTEALDRLLASDTVLEVVFEYQGHAIEVGSDGHVTIDGEDVEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4H4</accession>
    <name>R4W4H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446021.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01127">
        <property type="protein sequence ID" value="AGN01127"/>
        <property type="gene ID" value="L593_05890"/>
    </dbReference>
    <dbReference type="GeneID" id="16181624"/>
    <dbReference type="KEGG" id="sali:L593_05890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1206"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_2"/>
    <dbReference type="OrthoDB" id="35243at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="28850" checksum="70D93E6961D01AA7" modified="2013-07-24" version="1">MHLDPATSLAARPAPKIRAVAAEPGSILVVPVGSVEQHGEHLPVATDSLLAEAIAHGGVAEANGGVAEATGADGDADGAGEEATVPALVAPAVWTGYSPHHLPFGGTLTLGFQRLLGVLEDLAESGLGAGDDEGFDAILLVNGHGGNASLVDGAVSTIGVANPDAEVVGVTYFELAAGLLEDVRESDPGGMAHGGEFETSLMLHLHPDLVGEDQPAEPLETPYERGGTDLLEGGPVSTYRSFDAFSESGAIGEPEYASAKAGGAIFELLTEELASLLGEIHDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W540</accession>
    <name>R4W540_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L593_07785</name>
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            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01502.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01502">
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        <property type="gene ID" value="L593_07785"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
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        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="683" mass="75010" checksum="A20474F75F52C065" modified="2013-07-24" version="1">MLPAVSSRTRALDDTIFGVDVHSGDVRGDAPSYALVRIDWGGPDGGSGGEPGDSIDGPTIERDVVSHRKLRRLIASAEPALLATDNVYELATDADDLVRFLRELPDATRLVQVTGAEQPEPLSRVAKRHDVPYGKDPMQEAEASARLAAANVGQVVSAFTNTTNVKVARGRSVGGGGGWSEDRYTRKIHGAVKRRSREVESALEGAGLEFEKTVTEKYGGYSRAIFEVEASPEELPIGRERSGDVRIEIERERRDGIEFEPLAKRRDHVVVGVDPGTTTAVALVGLDGELLDVLSTRTADTAAVTEWIVERGRPLLVAADVEPMPETVEKLRRSFDAAGWIPESDLPIDTKQHRAPDHAYDNDHERDAIAAALFAFDDHEDQFERIARKVPRTVDRGEVTARVLAEETSVEAVLADLEDDGEDGGGSTDETAHQPRELSDDERRIRDLESQVDRLQDHVSALEATVAEKDDRIDDLESELEAARNRERQEVRETRAVTRLKRRNDALQRDLDAKEETIEALEGKLDRLKALWKLDHSNFADVDAEKRGLVPVKPIDEFTSSAIEAADETYGLAEDDVIFLRNAGGAGRSTAETLVEIGPRVVLLGEGNLSEIADAVLFQADIPVGPAADVAMQEVDELAVARDADVDAVIDDWKRRAREREREQTAEMVDQLISEHRAGDNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W576</accession>
    <name>R4W576_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446456.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08085"/>
    <dbReference type="EnsemblBacteria" id="AGN01562">
        <property type="protein sequence ID" value="AGN01562"/>
        <property type="gene ID" value="L593_08085"/>
    </dbReference>
    <dbReference type="GeneID" id="16182302"/>
    <dbReference type="KEGG" id="sali:L593_08085"/>
    <dbReference type="eggNOG" id="arCOG06404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147794_0_0_2"/>
    <dbReference type="OrthoDB" id="89774at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15647" checksum="0CB9959D6F1FD030" modified="2013-07-24" version="1">MDRVRSETLQTIDASLVGHGAIDRPAIELPDDVDTGTDGDVPAGEVVRLVLDGDTRHCRFEAYGGGTRATGVFDTPDLVRSPGDGENRLREWIDEHGLSVGRTVHLDVIEAGFSYGLRAPGDSAVYDAPASSPDDSLASIAEQLDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W595</accession>
    <name>R4W595_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_08260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08260"/>
    <dbReference type="EnsemblBacteria" id="AGN01597">
        <property type="protein sequence ID" value="AGN01597"/>
        <property type="gene ID" value="L593_08260"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1693"/>
    <dbReference type="eggNOG" id="arCOG04650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_5_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="8">
        <location>
            <begin position="15"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="7">
        <location>
            <begin position="580"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="838" mass="92854" checksum="208946BA4C7D32D2" modified="2013-07-24" version="1">MSTETHDEGGHLPPMTSVRRWLVTTNHKDVGLLYLATSLFFLVLGGVLALLFRIQLWGSGGGFLSALNYNQAVTIHGLLMVFWFLSPFAFGFANYIVPLQIGAKDLAFPRLNALSYWLYLASGLIVAVSFFQGGAFAGGWTMYAPLNMPINTPTIGGTATVLGLTLFIMSTTIGTVNFLTTIHRGRAEGMGLWNLPMFTWSILLTVWMMLFAFAALLAALLLLSYDRVIAAGLGGAEAVHYFGPEASGSLLWAHLFWFFGHPEVYIVFFPALGVMFEVFQTFTGRRIVGRKWVILAMVLVAVQSFLVWMHHMFLSAINLEIKTLMMATTIGISLPFDLMVFSMIYTTVKGRVRFATPFLFVLGSLLLFILGGITGVFLGAVVLDYEFRGTYWVVAHFHYVMVAGVTALVGGLYYWWPKMTGKMYSEYLGKLHFAAYFIGFNLLYLPMFFAWETPRRVFIYPEELAIFQKMATVGAFVFGLSFLIMFYNFAKSYRHGAEAPDNPWEYSQTAEWAIDSPPTLENWKGRVSYASGSLEFVKPGSNDAGGSTSATAADGGTAATDGGAVVAAGQLDTVEQVDDSHEEPHPDHASMWPATIGLGMFVLFLGLSGLTTTSGVLYPALTGTGLLIFLGAALGFGLEEFDAPEANVAERWPFEGVGKNKLGVWFFLASDVIVFGAVIGAYLFSRIAYGWSEWHHGEVVPPFLWPGMVNTFVLLTSSFTVVLAMVYAERGNKKGLVASLGTTLLLGIVFLGIKAWEWSYEFSHGVYPWTDIWYTSYFVTTGMHALHVILGLMVAGFMFWRSTNGAYLDDDEPVELFGLYWHFVDIVWVFLFPMFYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5A1</accession>
    <name>R4W5A1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5 10">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L593_08310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61292"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:61294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:16235"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446501.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08310"/>
    <dbReference type="EnsemblBacteria" id="AGN01607">
        <property type="protein sequence ID" value="AGN01607"/>
        <property type="gene ID" value="L593_08310"/>
    </dbReference>
    <dbReference type="GeneID" id="16182364"/>
    <dbReference type="KEGG" id="sali:L593_08310"/>
    <dbReference type="eggNOG" id="arCOG04139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_0_1_2"/>
    <dbReference type="OrthoDB" id="57213at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="12">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="13">
        <location>
            <begin position="198"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN01607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="33059" checksum="BDEFCFE6FE0A5317" modified="2013-07-24" version="1">MEVLVIGAGSLGSLVGGLLAPDHDVTLVGRDPHVSTIRTAGLAIGGEIQTRVEPSATIPQRVSASADLAIVTVKAGDTADAAETLTECDVEAVWSLQNGLGNEATLAEALDVPVLAGTATYGADQSAPGSVTCTGIGEVAIGPRPETETPEADLALAEEYGEALSGADAATTGGTDADADAESPPGLDVLVDPAMPERLWRKLAVNVGINPTTALARADNGALAEDEIAATARTAARETARVAQASGVDLDEADAAAELDAVVEATADNRSSMLQDVERGRRTEIDQLAGAVVDRAEEHEVSVPVARTLTALVRAWERANYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5H6</accession>
    <name>R4W5H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgtA</name>
        <name evidence="4" type="ORF">L593_08885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446616.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08885"/>
    <dbReference type="EnsemblBacteria" id="AGN01722">
        <property type="protein sequence ID" value="AGN01722"/>
        <property type="gene ID" value="L593_08885"/>
    </dbReference>
    <dbReference type="GeneID" id="16182567"/>
    <dbReference type="KEGG" id="sali:L593_08885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1822"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OrthoDB" id="10236at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="3">
        <location>
            <begin position="14"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="502" mass="54881" checksum="92723D9A9A81E5F0" modified="2013-07-24" version="1">MRECFELQAVDGAGRIGELTIPRADVTVETPALLPVINPNIDTVAPADLESEFGAEILITNAYIIHGNEGLREQALQEGLHELLDFSGAIMTDSGAFQLSEYGEIDVTTEEILQFQREIGSDVGTPVDLPTPPDVAREEAERQLETTLDRLQIADDAATGEMLVTAPVQGSTYPDLRERAARKAYATGLDVFPVGAVVPLLGDYRFADVVDVVAAAKRGLGEDAPVHLFGAGHPMMFALAAAAGCDLFDSAAYALYARDDRYMTVRGTEYLDDLEYLPCDCAVCTEYDADGLRDLPGGERERRLAEHNLSVSFAEIRRVRQAIRRGNLLELVETRARSHPALLAGYRALLEHAEWLAASDPIVKDTFFYTSTESADRPEVQRYHDRLERLDLAGVDTLLVTEADPGGGYDESWDLRPPFGPVPPALSRVYPLTAETPERPDRRARERAVDAIARLHACTSDVEITVGHRGWPDDVIADLPPSVEAVDVTAGDQGTGRSERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5I1</accession>
    <name>R4W5I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446626.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08935"/>
    <dbReference type="EnsemblBacteria" id="AGN01732">
        <property type="protein sequence ID" value="AGN01732"/>
        <property type="gene ID" value="L593_08935"/>
    </dbReference>
    <dbReference type="GeneID" id="16182578"/>
    <dbReference type="KEGG" id="sali:L593_08935"/>
    <dbReference type="eggNOG" id="ENOG502N65F">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420179_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="91" mass="9883" checksum="8652E29442EEF14B" modified="2013-07-24" version="1">MDDQAIKNEIVYAMVRKRITGGNKKQVTTIVGMPLPSHLEGRGKALIDDLVQDGVVERYGGGHRANVRLSSLDAGVAYLRANDGEVPFGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W617</accession>
    <name>R4W617_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">L593_00790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445007.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00790"/>
    <dbReference type="EnsemblBacteria" id="AGN00113">
        <property type="protein sequence ID" value="AGN00113"/>
        <property type="gene ID" value="L593_00790"/>
    </dbReference>
    <dbReference type="GeneID" id="16182089"/>
    <dbReference type="KEGG" id="sali:L593_00790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.162"/>
    <dbReference type="eggNOG" id="arCOG04465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_2"/>
    <dbReference type="OrthoDB" id="25435at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="188"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN00113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="347" mass="37687" checksum="D678294CEC3B78A9" modified="2013-07-24" version="1">MADEFTTTVYYDDDADSAHLDDKTVAVLGFGSQGHAHALNLHESGHDVVVGLRESSSSWDEAESAGLSVATPADAAAQADVVSVLVPDTVQPDVYENAIEPNLDAGDTLQFAHGFNVHYNQIEPPEDVDVTMVAPKSPGHLVRRNYERDQGTPALLAVYQDATGEAVDEGLAYAQGIGCARAGVIETSFQEEVESDLFGEQAVLCGGVTSLVKHGYETLVENGYSPEIAYFECLNELKLIVDLMYEGGHAEMWNSVSDTAEYGGLVKGDEIVDDHVRENMEETLEAVQDGTFAREWIAENQAGRPSYTQLRDAEMNHDIEDVGERLRALFAWADENEQEAAEAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W652</accession>
    <name>R4W652_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Riboflavin synthase subunit alpha</fullName>
            <ecNumber evidence="5">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10860</name>
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    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
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        <property type="protein sequence ID" value="AGN02117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AGN02117">
        <property type="protein sequence ID" value="AGN02117"/>
        <property type="gene ID" value="L593_10860"/>
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        <property type="term" value="F:riboflavin synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
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        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
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        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="4">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="216" mass="23155" checksum="DA79EF3B1BA1D22C" modified="2013-07-24" version="1">MFTGIVEGVGTVAERTETADGLRVRIAADWLDVPDRGASIAVSGCCLTVEDRGDGWFETFLAEETRAVTSLDDLAVGDEVNLERAMPADGRFDGHVVQGHVDETVAVRDVVAAGEDWRYTFDLPADDRYLVPKGSITLDGISLTVASIDAEAGTFDVAIIPETYEATTLSEKAVGDLVNVEYDVIAKYVESMLDGQGGDEQDDADAHPERLAGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W692</accession>
    <name>R4W692_9EURY</name>
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        <submittedName>
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            <taxon>Natrialbales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
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        <property type="gene ID" value="L593_01300"/>
    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_01300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.265"/>
    <dbReference type="eggNOG" id="arCOG00336">
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    <dbReference type="OrthoDB" id="414at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
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        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_PCMH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1049" mass="112912" checksum="3D48038E38EAAC5C" modified="2013-07-24" version="1">MAQREDPTGVDGADATTADPSTDPRANYDYRGGEEHRPALVAALRERIDGEVRFDEYSRQLYATDASAYEVTPVGVVFPKSTDDVAAVMAYCAEEEIPVLPRGGGTSLAGQTVNEAVVLDFTKHMDDVLAVDPSEAGLAGTARAQPGVTLGELNAACENHDLKFAPDPAWGDKSALGGAIGNNSTGAHSLQYGKTDAYVESVEAVLADGTMTTLGEVDLETIREEADPAPDSGDLLPRIYEAVRRAVDEYADEIDEAYPDMKRNVSGYNLDRLVAEARGGIGPTGEDFGESGTVNLARLLAGSEGTLGIVTEATVSLEPIPETKAVALLAYEDLVTAMEDVEPILEHDPAAVEVLDDVLLNLARDTEEFGALVNTVVPEGAGAMLLVEFYAEDDARGREQTADLLADRVPADVRETEFSPPGNVSTDAALRAFAGFEAHDQAERDRFWKLRKSGLPILLSRTTDAKHISFIEDCAVPPEHLAEYVERFEAILEDHDTFASFYAHAGPGVLHVRPLVNTKTLDGVEQMVGIADAVTDVVTELGGSVSGEHGDGRARSQWNKKLYGVEIWDLSRDLKAAFDPDWLLNPGQICGDETGAIDMSEHLRFDPEYAFESGFESTLEWENANGMQGMVELCHGCGGCRGKQDQTGGVMCPTFRAAEEESLSTRGRANALRQAMSGDLPAEATDEEFVEEILDLCIGCKGCARDCPSEVDMATLKAELTHQHHQEHGTTVRDRLFGDIRRWARLGSATAPVSNWLASLPGAGWLAEQTVGIASERELPTFARTSFTAWMADRDAGVDPADAERRALVFPDTYTEYMEPEIGKATVRVLEAAGVHVDVPEGVTDSGRPAFSKGLLDRARERAEQNVAALEPAIEEGWDVVTVEPSEAAMFQSDYATLLGSERVLTVAENTYGVAEYLDSFDLPVPSVDAGASDRSLVYHGHCHQTAIGRERHAPRVLERAGYEVEVLDSGCCGMAGSFGYEAEHFSMSEAIGGILFEQVDGAKASTEGPSTVVAPGTSCRSQFWDLRGTDAAHPVEVIDSALPDQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F2</accession>
    <name>R4W6F2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447166.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11645"/>
    <dbReference type="EnsemblBacteria" id="AGN02272">
        <property type="protein sequence ID" value="AGN02272"/>
        <property type="gene ID" value="L593_11645"/>
    </dbReference>
    <dbReference type="GeneID" id="16180771"/>
    <dbReference type="KEGG" id="sali:L593_11645"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_1_2"/>
    <dbReference type="OrthoDB" id="105276at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="24945" checksum="3B6DC7B7D851D0F5" modified="2013-07-24" version="1">MTTPELADRAAYVADADALVCADLHLGRDANSNVELPMGEASRIPERVSALLDRFEPGTVVVAGDVLHAFDSVPEGVTDALVAVEEAVADAGAELLLVAGNHDGMLESVTESRVVEAADLGNGTVVIHGDEQPSALELADLDADRYVIGHEHPAIVIEGQRHACYLEGPAPDGDASVFALPAFNRLARGTVLNGSRTGDPASPLLAEIRRFRPAVRDPEADETLWFPPFSELQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6F7</accession>
    <name>R4W6F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447176.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11695"/>
    <dbReference type="EnsemblBacteria" id="AGN02282">
        <property type="protein sequence ID" value="AGN02282"/>
        <property type="gene ID" value="L593_11695"/>
    </dbReference>
    <dbReference type="GeneID" id="16182411"/>
    <dbReference type="KEGG" id="sali:L593_11695"/>
    <dbReference type="eggNOG" id="arCOG08985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596671_0_0_2"/>
    <dbReference type="OrthoDB" id="26256at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029470">
        <property type="entry name" value="PDDEXK_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14281">
        <property type="entry name" value="PDDEXK_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="426" mass="49017" checksum="0CD4896C86C0C54C" modified="2013-07-24" version="1">MAESIDLQNELRELRESLEAIPAVEEPPQPLLRVLGSARSEQSWNTLLTYFLDPDQPHGFDASLLTQFLDLVDEHTVAPLDYYYRDLQTVRVDSEVSSPQNNRPDIVIRVPDKWFVCIECKVDAPEGQNQLQRYLNDPNIGGEEKEDYPDDGDFYVFLSRRGGNHAGSDGFADLYWEDVATVLQTELNRNRGQYPELSVNQLADFLNTIRGVTNMEPDDFTETQKEKIQLLAEYRDEIDELFGAADSLRSSLARNGEWAPPFLEIAEERDIWSEEWHARPDKYGCLFRDGWYLDGEGDPTTEVSDTREDGGHRLHLIHLIRNESSFRDGELTMKLRSSTNNDIRSEFHRRFNSDRWQEQLKPMLGKRDITNKGNKQDYTTKTYDVNQSRLPGSYFETLATAFEEHQQVAEIADQIHQEAVGGASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H2</accession>
    <name>R4W6H2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AXE1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02160"/>
    <dbReference type="EnsemblBacteria" id="AGN00383">
        <property type="protein sequence ID" value="AGN00383"/>
        <property type="gene ID" value="L593_02160"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02160"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018290_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="665" mass="71880" checksum="B8BDCFEFD93AEB00" modified="2013-07-24" version="1">MGTDESDDSGPVRIEGFGPGVDGYYDVGDQLSRYLTETANRFFTNERTTKRSIDSKAAFEARRADVRSTVLASLGGLPDRPDDLGVERHGTIERAGYHVDRITFESLQDFHVTANCYVPDADGPHPAVLFSCGHLGPAKTDELNQQACIELVRQGFVVLIYDPICLGERRQYDAPDASDPHVHSGVYGHSYAGQQCYFAGGNVARFMIADAQAGLDYLAERADVDEGRLGATGTSGGGILTTYLGLLDDRVAVAAPCCAVCERSEWLATGKTGDPEQILTGAIPNGVNADDVLTGMAPKPVCIGAAASDFFPIEGVEEVADRAERIYELYDATERLEVIVADAGHASVYEIGAELFAWFCAHLGDEPYTPIEGHDLADEDALRCTATGSVRAAFEDERSLGDVVAAFVDERRNAAASIDDGYDPERIEGALRERLDLARDRCERNPRVTARQEVGDLDVQRIFFMSERDPPIVVTGVLVADPNTAIDRPAVLCFDEGTGALPARSDEVISIAREHGAALVFDPRGVGAVRHREIPTWYAFGPNDHDQIYGTEYTLGHRALELGGSLFGDRVFDVTRAVAFLRSETAADDVHLLGEGVAAYHALYAAGTTDAVGSVEFRDLGPSFYERATGEYPYDPRLLVDDVLGEADVPAVLSALDDRGVLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K8</accession>
    <name>R4W6K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease subunit B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447281.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12220"/>
    <dbReference type="EnsemblBacteria" id="AGN02387">
        <property type="protein sequence ID" value="AGN02387"/>
        <property type="gene ID" value="L593_12220"/>
    </dbReference>
    <dbReference type="GeneID" id="16179813"/>
    <dbReference type="KEGG" id="sali:L593_12220"/>
    <dbReference type="eggNOG" id="arCOG00805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115437" checksum="9E3E396329785E03" modified="2013-07-24" version="1">MVGGCICYSPSYTALRDHAFNWLDTNTAESPESAVFLESNAHQRDAIATAWREEHDALRLTVTGIADFALTIHERLYGPYPGIETLERRRTIEQALHRLDENDVLRDAGQHTPSISELLRELEADGVRDIATLEDRLDSSTCTQHQQTVLTEVFEGYLELRGRIAHPESKTQNEKLAAVAETDQSLRTVLPHLDAIVISNLEDPSATELAVIERLAEDFPVRVLMPTVTPEAPTAGISTAVADTIAALRGMGFEEERVEAADPLPLRDVTTRLYQPVETPDAPPAELSWHEAPTPDREIRHVARRIREELATTDRQPDDLLVLAPGLLSYRDGIADVFDAYGIDHAYKVSILLERTYAGRAVLDAIECCEYPRSDRIAELATNPLVDIPGTDAVELADVQRRLYTTAIDAYVDELDASASGIDAFLDRVAAVREAEADAVVPAVRELLGHIGLESTVETLDENADFNAGYEARAVRRVDAILESVQTVCEEFDPDDPLGEVGTALEGVRVPSPTQVTAGNVEIIGLQDAPGADFEELYVLGATAQHLSGSETRPRFFQTLGEQLGVFERHAQRDVDRYRFGTLIGNAQRVHITTPETTIDDDPLLVSPFVDELARVTGLEPTGTLHDEPRASREDLQRDMAGAPPAALEPALAAARENGHVTDAFVATATRGAECGAHRGVQELTAHDGQLTTGSIESLDGKLTRAPYSYSRLTKYAKCGFKYLLSTGWGLDEEDDIEPGIDPLTLGSVVHETVETFYRDLQTEPGDPVDLTDHDQHDLEQGLLAAARDAVDDEDVSLHDVFGEKTLHALFSGLASPTENEYYSPPGNDSTDDPSGTFAQFLDTELDFAEDGHRPSYFEAELGDDDGVQLPDGRTVPVGGIVDRVDTTPDGLTVFDYKASSVNGARRRENQARDGIDFQLPIYSLAAPELVDTDLTPSDVAARYYVINDNPQVKPRRSLADRFDDIDYDAFITDVIPDRLDAVTGAIENGAFHPAVVGERTAQCSYCEFSDICDVRHHRRYDVVDHVTDTGHHAYVPAGAGAGDVLDELPGGDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6K9</accession>
    <name>R4W6K9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrkA-C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445347.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02510"/>
    <dbReference type="EnsemblBacteria" id="AGN00453">
        <property type="protein sequence ID" value="AGN00453"/>
        <property type="gene ID" value="L593_02510"/>
    </dbReference>
    <dbReference type="GeneID" id="16180225"/>
    <dbReference type="KEGG" id="sali:L593_02510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.509"/>
    <dbReference type="eggNOG" id="arCOG07570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053275_0_0_2"/>
    <dbReference type="OrthoDB" id="75440at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="42889" checksum="48EE07D7544F31A6" modified="2013-07-24" version="1">MSLPAEFVLGLYIGLLTGIIPALVAGVLGFVFRYFTGVTLPGLGVVVLAVAVAGVNGGLLGLIDPTIQQSPRLLVALTVVMMLALYAHNQGDKLGASLPRRFSLRSLRRQTLSADVISVVGGIGQVTIRPVGEVDDVEGYPPLGAELRGEIASETWDLPADLPLAELEARLEDRLRTDYDLADVSVAIDERGRASIAAAPPMGGLSRRIPEGHRAVSIAALVPTGIARGDRVRLDAGDDRFDGRIVSARSDAAPRSPIGGDPAATDGGQPTAGSAPAAPTAPTTAGGEGRVTVALPRSRATKLLSYDRGRVVVRSRGTRREFELLSLFRRSGKRIAKVPIGAGSPLAATTIGEAAIRDAHGVAVLAVRSTRGDSSKKSWTFSPDGSTLLSAGDECFVVGSRDAIEQFRGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6M4</accession>
    <name>R4W6M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02412">
        <property type="protein sequence ID" value="AGN02412"/>
        <property type="gene ID" value="L593_12365"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12365"/>
    <dbReference type="eggNOG" id="arCOG11141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131907_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="14718" checksum="0481472F348B21B8" modified="2013-07-24" version="1">MSESTTDTERERASPMFDTGAMKWVSGIASLIGLWIAASPFVYDTTTMATWNNVAIGLGIFLVAGFTYYQLAGGMFAAVGALSLVVLLGLWTIAAPYVMDFESNALLLSNVAAGAAVALISAYNAYANREAQAAGMTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6N1</accession>
    <name>R4W6N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445377.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02660"/>
    <dbReference type="EnsemblBacteria" id="AGN00483">
        <property type="protein sequence ID" value="AGN00483"/>
        <property type="gene ID" value="L593_02660"/>
    </dbReference>
    <dbReference type="GeneID" id="16180295"/>
    <dbReference type="KEGG" id="sali:L593_02660"/>
    <dbReference type="eggNOG" id="arCOG02706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_2"/>
    <dbReference type="OrthoDB" id="100669at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="13505" checksum="AEFE570D1C1ABD49" modified="2013-07-24" version="1">MEFHHAGIAAEDGAATAALFADLFDTEVVHEESLDDLDVVFLEVGDGLLEILEPTADGTVARFVDREGPGIHHLAFATDDLPGAIEHARSLGIEPIDEEPRPGAAGHDVAFLHPRDTAGVLVEFVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6T5</accession>
    <name>R4W6T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445457.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03060"/>
    <dbReference type="EnsemblBacteria" id="AGN00563">
        <property type="protein sequence ID" value="AGN00563"/>
        <property type="gene ID" value="L593_03060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180361"/>
    <dbReference type="KEGG" id="sali:L593_03060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.619"/>
    <dbReference type="eggNOG" id="arCOG01064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_0_2"/>
    <dbReference type="OrthoDB" id="25371at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="381" mass="41921" checksum="E0F34E05FB879DFA" modified="2013-07-24" version="1">MTEHVVIVGAGTGGTVLANDLADRLEREIDAGDIEVTLYNDDPDHVYKPVWLYVPFGLREPEDGRRPLSDLVDDRVDLRIDRITDIDTDAKELRTRDAAGTVSYDHLVLATGSTLAPEVVPGLAEAGHNFYSQDGAEALREDLLSFEEGRVVLSVVGTPHMCPAAPLEFAFMVDDWFRERGMRDDVEVVYTYPIQRVHGNPHIAEWAEPLMHERDIEVQTFVNAESVDPDAETIETMEGDSIDYDLLVTIPPHEGVDLITEAGLGDEGWVDVDSNTLEATEAEDVYALGDTADTGVPKAGSVAHYQAGVVAQRIASEVRGRPATATYDGKTLCFIETGMDEASFVEFDYENPPSPAPPSQALHWSKLSYNESYWLTARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B8</accession>
    <name>R4W7B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445772.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04645"/>
    <dbReference type="EnsemblBacteria" id="AGN00878">
        <property type="protein sequence ID" value="AGN00878"/>
        <property type="gene ID" value="L593_04645"/>
    </dbReference>
    <dbReference type="GeneID" id="16181319"/>
    <dbReference type="KEGG" id="sali:L593_04645"/>
    <dbReference type="eggNOG" id="arCOG00844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_3_2"/>
    <dbReference type="OrthoDB" id="83657at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="18991" checksum="066EB23811E4761B" modified="2013-07-24" version="1">MEIRQPAGLDDFRAAIDAHNRAWRVGYRGIVSADVIDAQVRPTEEEYLEELDEDVAAEPGPFLVAETDDGDVVGFVRARYTGTSAFVAGLGGEIRDLYVDPAHWREGVGSALLASAVEWLPDMIDGISVAVLVDNERARSFLEANDLVFEETTDIDLAGDPHEHAVYRIGFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F3</accession>
    <name>R4W7F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04945"/>
    <dbReference type="EnsemblBacteria" id="AGN00938">
        <property type="protein sequence ID" value="AGN00938"/>
        <property type="gene ID" value="L593_04945"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04945"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="122"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="32290" checksum="4D3447F2CA407923" modified="2013-07-24" version="1">MQVARAEDVDVILSKTRKTYLPGLVAARRVGVPHVVHVGVLPEATRAGFVERLDTASLQARLRAPHDGYFVVCEAVAGVLRGLGVRNDRIYDIKNAVDTEVFSPDAVSEYPDWLENTVAGAGERFVVGYVGGLQVYKGIRDLMPAIRRSDDDVQIFIAGDGPQRGWLEAELKGRGSFLGSVPYDSMPAVYDAMDALVLPSYTEGLPRVVLEAQAMATPVIASRVGGVPEVVEDGETGFLYEPGDAVGLSDAIDQVASGEDLRRRIGQRGRANVVEKWSWVQLYDRYEKFLKQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G3</accession>
    <name>R4W7G3_9EURY</name>
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        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05020"/>
    <dbReference type="EnsemblBacteria" id="AGN00953">
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        <property type="gene ID" value="L593_05020"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05020"/>
    <dbReference type="eggNOG" id="arCOG02053">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="158" mass="16956" checksum="0CFB5E6DEBB806C5" modified="2013-07-24" version="1">MFDSILVVTNGTDPGSRPAERAVALAETHDAELHALYVVDVAKDWDMAVERREAEGEAAVEFVANRGAERDVPVVKHFRYGRTHEEIVDYAAAHEVDLVVVPSTTRRGLSRMLAPTDLAERVIGRTDVPVLGIDVADATEHGSAEEAGDGANAPTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7U9</accession>
    <name>R4W7U9_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2613793_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="78" mass="8854" checksum="2C8E36D6F33F0DC1" modified="2013-07-24" version="1">MGEESTAYATRVSRERARAIEAAREQMGVTQSEFVERALRYYLEKNPKDIPALRTESKNNRPIGGTDPYDPTQESFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X6</accession>
    <name>R4W7X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445043.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00970"/>
    <dbReference type="EnsemblBacteria" id="AGN00149">
        <property type="protein sequence ID" value="AGN00149"/>
        <property type="gene ID" value="L593_00970"/>
    </dbReference>
    <dbReference type="GeneID" id="16179941"/>
    <dbReference type="KEGG" id="sali:L593_00970"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.199"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="245" mass="26301" checksum="67844B87C5FB588C" modified="2013-07-24" version="1">MEGRTCLITGASKGIGRGIAEHLGESGANVAVNYRSSVEEAEEVVETIEDSGGQAIATRADVTGRREVEAMRDEIHDAFGPIDVLVNNAGITQDTKFEEMTREEWDTVIDVHLGGAFNCTQTFFDDIKQSEYGRLISISSIVGKQGNFGQANYAAAKSGLFGFVRTLALELAESGSTANCVAPGFTETSMLETVPDRVREVILEDIPLNRFGSIDDVACVVEFLASEESSYITGEVLDVNGGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Y2</accession>
    <name>R4W7Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_06805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446202.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06805"/>
    <dbReference type="EnsemblBacteria" id="AGN01308">
        <property type="protein sequence ID" value="AGN01308"/>
        <property type="gene ID" value="L593_06805"/>
    </dbReference>
    <dbReference type="GeneID" id="16181879"/>
    <dbReference type="KEGG" id="sali:L593_06805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1390"/>
    <dbReference type="eggNOG" id="arCOG01273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_0_2"/>
    <dbReference type="OrthoDB" id="49280at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
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        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="483" mass="50747" checksum="C5DFE81B11801F13" modified="2013-07-24" version="1">MSGDDTSGDGGREEIREDGGGDAGAGTAETGATRGGLRGRAAPYADGIRSRMTAMPRWKADAVVVLTTLALVYVLFVVLSWGQGLDANGTANTLARLTFLAAAYALLVLALNLHWGYAGLFNIGVAGFMSVAVFTLAIVSGGEGVGFGLPIWAGMIAGMLAAAALGAIAALPALRLRADYFAIVTLGIAEIVRFLMKSQWLAQHHVFGNEIGLQGSAPVQVPSAQEYVYKLFTVDGSPRSDPTYLGTQFFVIGEWFGLERTTVMAWGYAVFVALFVVFAYLLLSRIAYSPFGRILKAIREDEGAAQALGKPTSRIKIYSFVLGCAIMGLAGMLWQASRFTVGADAFVPILTFYVFVALIVGGSGSNAGSIVGGIAFVGLLLQGPRMLQRVISEHTDVSSTDTIYEAVTAFASFDVMPFVGYAIGNIDLLQRLFVGLVLIVLMLRRPDGILGHRKEIAAATDLSRPAEGRGSGSAATAGGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Z5</accession>
    <name>R4W7Z5_9EURY</name>
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            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">L593_07005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="146"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="176"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="352" mass="35625" checksum="17124C34A62C7CB9" modified="2013-07-24" version="1">MDRRAVATTLAGFLAAVAMFAVMFTLVDTDGVVAAVERADLRLVALVGVTTICWVCFWGLALWNVLGALDVTVPVRDALLVTAAGIFVNHVTPFGQAGGEPITAALLSRRTDANYDVSLASITSFDAVNVVPSLTFAALGIGYFAATSAVGSQLGLLLGGAAIVIVGAPVAGFAIWRKRAWIERGLVRFVTRAIEIGAPVLPLVSREDADDVAAGIAGYVESLEVVASDRRRVLAAIGCSGGGWAIQAIGLWIAFQAIGVDVPLYVPFFVVPIGTMASVLPTPGGLGGIEAVTVTLMTLVTGVAGADAAVAVTLHSVGGYLLSGTVGAGAAVVLGLRPKSIAGGGDRGGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W806</accession>
    <name>R4W806_9EURY</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07230"/>
    <dbReference type="EnsemblBacteria" id="AGN01393">
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        <property type="gene ID" value="L593_07230"/>
    </dbReference>
    <dbReference type="GeneID" id="16179939"/>
    <dbReference type="KEGG" id="sali:L593_07230"/>
    <dbReference type="eggNOG" id="arCOG06327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182710_0_0_2"/>
    <dbReference type="OrthoDB" id="122063at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="8240" checksum="4E61BE514C81FC8E" modified="2013-07-24" version="1">MGGKQTEACGRCSVTAVLDAKEAVDDEDAESGGQNPFDGERIELGERELTSVVRHEVAAGKLKSKLDAFATRVIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8A3</accession>
    <name>R4W8A3_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Nitrogen-fixing NifU domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">L593_08315</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08315"/>
    <dbReference type="EnsemblBacteria" id="AGN01608">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1704"/>
    <dbReference type="eggNOG" id="arCOG03026">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01106">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="2">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="120" mass="12551" checksum="796578FCBDD986B1" modified="2013-07-24" version="1">MSTETQEGDDLEERVANFLRRNFPQIQMHGGSAAIQDLDRETGEVTIQLGGACSGCGISPMTIQAIKSRMVQEIPEIEQVHASTGMDGGGHGGGGMSPSFPGEDAGGEESTEDEGPQAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D2</accession>
    <name>R4W8D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445438.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02965"/>
    <dbReference type="EnsemblBacteria" id="AGN00544">
        <property type="protein sequence ID" value="AGN00544"/>
        <property type="gene ID" value="L593_02965"/>
    </dbReference>
    <dbReference type="GeneID" id="16180337"/>
    <dbReference type="KEGG" id="sali:L593_02965"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="138"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="280" mass="29660" checksum="EBEDF09D228F866E" modified="2013-07-24" version="1">MLERICIGVDGSDCARRATAVGVAIAEAADAHVDLVYVRKETDETAEQDANAVLEDALESCEDASVQVDGHSLTGKPATRLVSFADEHDADLLVLGRIGRTGLGKRLLGSVVHSAFRQSDRPILTVPEGDGQVEISDLLVPTDGSEAAERAAPMAGTIATDHDATVHALYALDLATAVGPFSAGGLTGPEIERLEADRKAHVDRLADRLRSDDAERSIQTVVVRNSPHRAIRDYVDEAGVDLVVMSSRGQTSALGQVLGSVTDRVLRTVDVPVLVVTDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L7</accession>
    <name>R4W8L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446817.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09890"/>
    <dbReference type="EnsemblBacteria" id="AGN01923">
        <property type="protein sequence ID" value="AGN01923"/>
        <property type="gene ID" value="L593_09890"/>
    </dbReference>
    <dbReference type="GeneID" id="16182848"/>
    <dbReference type="KEGG" id="sali:L593_09890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2036"/>
    <dbReference type="eggNOG" id="arCOG04687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112755_0_0_2"/>
    <dbReference type="OrthoDB" id="113574at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="209" mass="22231" checksum="BF0EEADEEE80FD80" modified="2013-07-24" version="1">MEATDVRDAVQEQKATELSRLGSSKSLYAATAGEMESEAVLAAAADADRAAADCFAAWAEDESDEDARAAFEATAEEEDSHVETILAELDDYEASADGDELADHLTGIEGTAARAGAFLGRVLVADEQKSQYVGYFVGNADPQTASVFRDLRGDLDEQEGRAMELLDVICDSDDDWDTAQAAALEAVQIAYEAHVSTLEDLGVDPKPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M3</accession>
    <name>R4W8M3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lysK</name>
        <name evidence="9" type="synonym">lysS</name>
        <name evidence="11" type="ORF">L593_03940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03940"/>
    <dbReference type="EnsemblBacteria" id="AGN00739">
        <property type="protein sequence ID" value="AGN00739"/>
        <property type="gene ID" value="L593_03940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.801"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="82"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="371"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="617" mass="68010" checksum="DF110B773933AC8E" modified="2013-07-24" version="1">MSTDDDAGERSTTGAPATGSDDDLSASDDADPYTLQATGGEDAEQTQDADAGYHSFWADEIADQIEARDPEEPIVIKGGISPSGIPHLGNANEIVLPYFVAEVLRERGFEVRQIFTTDDRDPLRGLPRKLADLDGEIVGLGDVDAAALGQNLGKPYTDIPDPFGCCDSYGAHFSTLIAGIAEQLQVPVDVVSNTELYESGALDDQTRLVLEREDLARETLAQYQDKVDEDYVPFNPICEECGKLTETVTSVDLDAGGPVPGADDPTAETDSDDASATPIGTVDYRCTDLDAGDDTIEGCGHEGTATLREGKLPWRFEWVAQWAELGVDFEPFGKDHAEGSWPSGVDVAETVFEIEPPLPMVYEWFTLDGEPFSSSGGHVVLVSEVLELIEPEVVRYFFAKDPSKARDFSIEHLDQLVAEFDRIERLYFAAAEGATADSLDATEAEVAFAERVYPFLVDEVREERIRIPYPFAAVLGMTDDPELREEIARREGHVPDDAPEWAVEEALDRVERAREWARSTDNEYNYELKRESMPDIDIDADTEAALDDLADFIAANDDPDAIQGEVYEAAKRHDLDVGEFFATGYRLFFDQEEGPQLGNFLAKLDEAFVLRRLRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N1</accession>
    <name>R4W8N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">truA</name>
        <name evidence="10" type="ORF">L593_10040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446847.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10040"/>
    <dbReference type="EnsemblBacteria" id="AGN01953">
        <property type="protein sequence ID" value="AGN01953"/>
        <property type="gene ID" value="L593_10040"/>
    </dbReference>
    <dbReference type="GeneID" id="16179998"/>
    <dbReference type="KEGG" id="sali:L593_10040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2070"/>
    <dbReference type="eggNOG" id="arCOG04449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_4_2_2"/>
    <dbReference type="OrthoDB" id="62389at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="9">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="30025" checksum="5D687EDB442EE755" modified="2013-07-24" version="1">MRAFRIAYDGRPFYGFQRQPDVPTVEDALLDGLEALDVLDPDADSGVGVRPTPPGYAAAGRTDAGVAALAQTIAFEAPAWLTPRALNGALPDSVHAWAHADVPSDDPDAPADFHATHDATRRQYTYHLHAPAADPDLAADALDRIVGEHDFAALTTDDTGTVRTLETGATWAEPYLVIQVAAGGFPRHLVRRLASLVDLVATGERAPSFVDRVLDGSSVPESDGVPTAPAEPLVLADVAYPGLSFSVDETAATSARDALERRRREARTRSRTMAELADGLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N6</accession>
    <name>R4W8N6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446857.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10090"/>
    <dbReference type="EnsemblBacteria" id="AGN01963">
        <property type="protein sequence ID" value="AGN01963"/>
        <property type="gene ID" value="L593_10090"/>
    </dbReference>
    <dbReference type="GeneID" id="16182722"/>
    <dbReference type="KEGG" id="sali:L593_10090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2080"/>
    <dbReference type="eggNOG" id="arCOG02254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167318_2_0_2"/>
    <dbReference type="OrthoDB" id="115424at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002753">
        <property type="entry name" value="UPF0058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036519">
        <property type="entry name" value="UPF0058_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42203">
        <property type="entry name" value="PTHR42203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01893">
        <property type="entry name" value="UPF0058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140371">
        <property type="entry name" value="SSF140371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="78" mass="8543" checksum="747B0B3D54632D16" modified="2013-07-24" version="1">MKKQELIHLHGLLAEVSADVEAHLGSELDLSTYEEMGVRPTSIHKSKTDHKTAVFALARGITDDMSEDVEERVPAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P5</accession>
    <name>R4W8P5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="6" type="ORF">L593_10190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446877.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10190"/>
    <dbReference type="EnsemblBacteria" id="AGN01983">
        <property type="protein sequence ID" value="AGN01983"/>
        <property type="gene ID" value="L593_10190"/>
    </dbReference>
    <dbReference type="GeneID" id="16181314"/>
    <dbReference type="KEGG" id="sali:L593_10190"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2100"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OrthoDB" id="57654at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="26742" checksum="F92587118B6992BE" modified="2013-07-24" version="1">MQGSQQQQAYDRGITIFSPDGRLYQVEYAREAVKRGTAAVGVRTSDGVVLVADRRTRSPLVEASSVEKLHEVDDHLGIASAGHVADARQLVDLARRRAQMEWLRYDQPLGVEALTKEITDHIQQYTQTGGARPFGVALLVAGIEDGEPRLFETDPSGTPYEWSAVAVGGGRDTIQEYLEDHYGESLTLDDGIGLALEALASASDGDLDPHGVEIATVDVESERFDALDPDTVAAIVTEHGLAEEGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P6</accession>
    <name>R4W8P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445698.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04265"/>
    <dbReference type="EnsemblBacteria" id="AGN00804">
        <property type="protein sequence ID" value="AGN00804"/>
        <property type="gene ID" value="L593_04265"/>
    </dbReference>
    <dbReference type="GeneID" id="16180509"/>
    <dbReference type="KEGG" id="sali:L593_04265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.868"/>
    <dbReference type="eggNOG" id="arCOG02797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193458_0_0_2"/>
    <dbReference type="OrthoDB" id="112562at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036825">
        <property type="entry name" value="MTH865-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024093">
        <property type="entry name" value="Uncharacterised_MTH865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07747">
        <property type="entry name" value="MTH865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69025">
        <property type="entry name" value="SSF69025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="83" mass="9097" checksum="F8C00E78D7A8CD3A" modified="2013-07-24" version="1">MADEAELREQMIDAFEGADYPISSPMDLVPALPDGPSTSFESGDFSMTAMELNTKLGGGEFPYDDVESFVDDVLEQLEDQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P9</accession>
    <name>R4W8P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-Nucleotidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04315"/>
    <dbReference type="EnsemblBacteria" id="AGN00814">
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        <property type="gene ID" value="L593_04315"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.878"/>
    <dbReference type="eggNOG" id="arCOG02832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434538_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C"/>
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        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="65"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="383"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="69026" checksum="E95637E2AFD599CF" modified="2013-07-24" version="1">MQESAWPATGRYPARIIGSWTQRLTGWNPYPDGATMTATEAAIGEWRTLDGNPVRDGEGEPDLVFAHVSDLHGQLTPRYQVYYDNARSSPPVEFGSGGRTIERGGGVPLLAATLEELRAAHDVCTLMSGDTFHGSAATTYTDGRAMLDPVNDHVDPDVYVPGNWDYSNEAAEDGVFLELMDGLDAPVLANNLYDWDTGERIYDAYELLDVGGISVGVVGMTNVYVDRMAPAFYEGKYRFGKHPALLEESARAAREDGADVVVAVTEIGLPWMVQAATDCPTVDVMFSAHTHEYTYEPIVVEATDTVVVESGMGEALGRVDLRVRDGELQFRHHLYCLIEGNEATPEPDPAARETVERVRAPFFNDDPGFERGAGTLDQPLDTVVGETDTPLYRQSFLESAWNTLFNDALRAHFDADLAVSHGFRYGTAIPPGEITLGDLYTFFPMATPVARGVAYGQQLTSHMESFLEDNFTPYPYDQEDGRVRNFSSNVEVTLDPTAKRGRRLVGLRVDGEPIDPEATYSVATFRRPGDPERDLGNCGFPFRDIAVDDGTTPVDVIVEYLEANSPVDYEVMGLVETAEDGGRAQNTPADGPYPFVQPGVDYQDGEAYCETAMIPDGNAFPAEGRNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T9</accession>
    <name>R4W8T9_9EURY</name>
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    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446977.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10690"/>
    <dbReference type="EnsemblBacteria" id="AGN02083">
        <property type="protein sequence ID" value="AGN02083"/>
        <property type="gene ID" value="L593_10690"/>
    </dbReference>
    <dbReference type="GeneID" id="16180051"/>
    <dbReference type="KEGG" id="sali:L593_10690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2204"/>
    <dbReference type="eggNOG" id="arCOG02053">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_4_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="139" mass="14991" checksum="2665CF2D3CEB5D1D" modified="2013-07-24" version="1">MKRVLVAYDGSQQADAALDHALAEFSDAELHVLCVLDPAEATYASTEEMPAVADGWYDEATEEAERILAEAEERAGDRELVTAHVVGRPGHSIVEYAEEHDVDQVVTGSHGRTGVARLLLGSVAETIVRRSPVPVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8W7</accession>
    <name>R4W8W7_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447042.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02148">
        <property type="protein sequence ID" value="AGN02148"/>
        <property type="gene ID" value="L593_11015"/>
    </dbReference>
    <dbReference type="GeneID" id="16181397"/>
    <dbReference type="KEGG" id="sali:L593_11015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2271"/>
    <dbReference type="HOGENOM" id="CLU_2893417_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="62" mass="6874" checksum="6CA52617A0EE5EF4" modified="2013-07-24" version="1">MVESVLLAGAFAALLLHPVVIYGLYRLLTPTPETASTDRERMVAGAERDRHRERRIPGGNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z7</accession>
    <name>R4W8Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_11315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11315"/>
    <dbReference type="EnsemblBacteria" id="AGN02208">
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        <property type="gene ID" value="L593_11315"/>
    </dbReference>
    <dbReference type="GeneID" id="16182736"/>
    <dbReference type="KEGG" id="sali:L593_11315"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076274_1_0_2"/>
    <dbReference type="OrthoDB" id="85529at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="25631" checksum="D6133E26DE6C9F5D" modified="2013-07-24" version="1">MSVIAELTISSPILFESTFEKTPDVELVFEDAHYVNTGQTTVEYVFFLWVTGASPEQFEAAVAADETIEYVKRLVEAENRTLYRVVTPDLRPAEEPLFFPLCRRHDVTVIETRRTVTGFHAKIRIPTRDGFRSFQRVLAERGATVDVRKLHTGETEQSSLSHLTEKQREALQLAYDRGYFETPKSVTLSELADEFGVAPQTLSRHLRVAVESLVERAVSSTYSQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W905</accession>
    <name>R4W905_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447127.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11440"/>
    <dbReference type="EnsemblBacteria" id="AGN02233">
        <property type="protein sequence ID" value="AGN02233"/>
        <property type="gene ID" value="L593_11440"/>
    </dbReference>
    <dbReference type="GeneID" id="16181952"/>
    <dbReference type="KEGG" id="sali:L593_11440"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2360"/>
    <dbReference type="eggNOG" id="arCOG06430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485876_0_0_2"/>
    <dbReference type="OrthoDB" id="105171at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="164" mass="18351" checksum="2F4544D6A290B21D" modified="2013-07-24" version="1">MSLGQRVATDHQLARLLQIGVVLEEVVEARAERHLAELDPGERAALDDEVEALLADAAEESATHRDRLAALVDALDAEATGFEEIEALVEERYTAPGDTDGVLYDQLCNEETAYKFYDDFIAAIEGSDTEFSVDREHVLDTLREIREEEAEGVEEVTELMEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W919</accession>
    <name>R4W919_9EURY</name>
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        <submittedName>
            <fullName evidence="6">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446023.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05900"/>
    <dbReference type="EnsemblBacteria" id="AGN01129">
        <property type="protein sequence ID" value="AGN01129"/>
        <property type="gene ID" value="L593_05900"/>
    </dbReference>
    <dbReference type="GeneID" id="16181539"/>
    <dbReference type="KEGG" id="sali:L593_05900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1208"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="559" mass="58100" checksum="A3C0C4A81E803238" modified="2013-07-24" version="1">MGNQPLIVLSDDSQRTSGKDAQSMNITAGKAVSESVRTTLGPKGMDKMLVDSTGNVVVTNDGVTILKEMEIEHPAANMIVEVAETQESEVGDGTTTAVVVAGELLKKAEDQLDQEIHATTLAQGYRQAAEEAKDALEGIAIDVEESDTEILENIAATAMTGKGAENARDHLASLVVQAVRSVADEEGIDTENIKVEDVVGGAIEESELVEGVLISKERVHDDMPYAVEDANVAVLDDALEVRETEIDAEVNVTDPDQLQEFLDQEEEQLKEMVDQLAEAGADAVFAQDGIDDMAQHFLAQEGILAVRRTKSSDASKLARATGANVVSNVSDVEADDLGFAGSIAQKDVGGDQQIFVEDVEEAKSVTLILRGGTEHVVDEVERAIEDALGVVRTTLEDGKVVPGGGAPEIAVGLALQDFADSVGGREQIAVEAFAEALDVIPRTLAENAGLDPIDSIVELRSEHADGDSNAGLDAYTGDVADLSEDGVVEPLRVKTQAIESATEAAVMILRIDDVIAAGDLKGGQTGDDDDDAAGGPGGPGGMGGGMGGMGGMGGMGGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W926</accession>
    <name>R4W926_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447192.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02298">
        <property type="protein sequence ID" value="AGN02298"/>
        <property type="gene ID" value="L593_11775"/>
    </dbReference>
    <dbReference type="GeneID" id="58789377"/>
    <dbReference type="KEGG" id="sali:L593_11775"/>
    <dbReference type="HOGENOM" id="CLU_510595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="533" mass="56856" checksum="569034728725BE81" modified="2013-07-24" version="1">MTQHDQGDERRRNDDESNAGSGLSRRGLLGVTGSAILGTSLADPAFARSTQSDDETDSISYGTVTWVEVDEDDPEGLRGHYESVSFQGEAGDVVEIRVYPPSTAADYGVTLVLEAESVVGSEQFTDGQAEGRRIGPYELPETKAYQILVTTSEPADTGAFQLELEKVGSGGSTPAETAPPDAPFAARLVDSRANALAGGTVRVYRDEDDEQLASSEVGDGGWVTLDAGTLESIGAADRVHVLARSGDWFDGFTFEGGSLAENHGEDLPLRRELLYGPEIADSGSGPLGVVSVWRQIGFPDPALQTICVEVTNAATAAEPSNVGTRAFDLTDGLISLSYPEDDVLVSYGAYTDVEHPREMDVASVGTPHEGSMSRDREERPRLPVEVYHPARTGVPMGGTSIVSYEPLETSAAEERINEGTGRIVSSLPFVGMALGIGDLLHWGFGDPVERSASLGVEDPMPVDPNRWDTATLPWTSDSGVFEEASVLGVFPVRLDTDESTTIDVRAEWTMESVLFGFGTGSGSFARQFEIGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W962</accession>
    <name>R4W962_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01199">
        <property type="protein sequence ID" value="AGN01199"/>
        <property type="gene ID" value="L593_06250"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06250"/>
    <dbReference type="HOGENOM" id="CLU_2079520_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="117" mass="13256" checksum="BDE3EDD000216223" modified="2013-07-24" version="1">MVRITDEPAMHSNKLATKIIYDGSKAEYKESIDKVVDNVEYMQENMKQVAGNFLVNLYNPTKEEWGDEEMARDLSRYLLEEDVNIGVVELVVKDLWENPPAENEDSVQSDGGSAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W967</accession>
    <name>R4W967_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447327.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12470"/>
    <dbReference type="EnsemblBacteria" id="AGN02433">
        <property type="protein sequence ID" value="AGN02433"/>
        <property type="gene ID" value="L593_12470"/>
    </dbReference>
    <dbReference type="GeneID" id="16180851"/>
    <dbReference type="KEGG" id="sali:L593_12470"/>
    <dbReference type="eggNOG" id="arCOG09236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141587_1_0_2"/>
    <dbReference type="OrthoDB" id="101118at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="121" mass="13770" checksum="06FF2DB4B793781F" modified="2013-07-24" version="1">MSGIVFFRTERRSEVTAFYTDRLGFDRWLEQDGGCTILQYDNLLVGFCDSDSTDTEGIVTVVLEDEAAVDDLYRELSDIAHDPPEANDEFEIYQFFADDPDGRTVEVQTFRNPAPPTNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W980</accession>
    <name>R4W980_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unsaturated glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446143.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06510"/>
    <dbReference type="EnsemblBacteria" id="AGN01249">
        <property type="protein sequence ID" value="AGN01249"/>
        <property type="gene ID" value="L593_06510"/>
    </dbReference>
    <dbReference type="GeneID" id="16181772"/>
    <dbReference type="KEGG" id="sali:L593_06510"/>
    <dbReference type="eggNOG" id="arCOG02007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_1_1_2"/>
    <dbReference type="OrthoDB" id="56171at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="383" mass="42349" checksum="0A7090199537F80F" modified="2013-07-24" version="1">MQPDAERAFEQMVARVDTTLDAVGEAFPYVAEPDTGAWTTTDDGNWCGGHWVGLLWLAHEYTGEDRFRTAAERATETVVASVEPRSMFYGMNANYCGFRAFDLTGEQRFREIGIDGADRTVDYFHQGARQVPLGTQPIEAPATNFRGPEADEGPSGDVLGAVDSVYTALPVLWRAYRETGDPTYRDTAVSHADRTLDWFVREDGRTWHHAEFDPETGELVRQYNELAYSDDTCWARGQGWAIAGLARAYDETGAERYLDALERTVGYYETHAPADLVPYWDFEHPDAPDVPRDTSAAGLAAYGLTRLDDSPETADLRETGDAILDSLVENYQTPTGAEDDRQPGMVIEGCYNGPAGYADANELVWTDYYVAVALANRAGVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A9</accession>
    <name>R4W9A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446228.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06935"/>
    <dbReference type="EnsemblBacteria" id="AGN01334">
        <property type="protein sequence ID" value="AGN01334"/>
        <property type="gene ID" value="L593_06935"/>
    </dbReference>
    <dbReference type="GeneID" id="16181935"/>
    <dbReference type="KEGG" id="sali:L593_06935"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1417"/>
    <dbReference type="eggNOG" id="arCOG04171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135994_0_0_2"/>
    <dbReference type="OrthoDB" id="112766at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="166" mass="17524" checksum="CCA2C43E739413B1" modified="2013-07-24" version="1">MSEDTDALASDAEQVRYEEVLRATGHEHVQGTHASTFEVTTDDFLTPAGDCIVGIEADRAPASFDDAFVAACQDPDATIVTELSVAGDEGEDSADGPATQRIVARGDPDLSFENDRSAVWRTSEYVDDRTVAVEADHAAADLDRDLVTALAAGAELEVTIVVEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C4</accession>
    <name>R4W9C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione s-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447447.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13070"/>
    <dbReference type="EnsemblBacteria" id="AGN02553">
        <property type="protein sequence ID" value="AGN02553"/>
        <property type="gene ID" value="L593_13070"/>
    </dbReference>
    <dbReference type="GeneID" id="16180386"/>
    <dbReference type="KEGG" id="sali:L593_13070"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2679"/>
    <dbReference type="eggNOG" id="arCOG04712">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_0_2"/>
    <dbReference type="OrthoDB" id="35759at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="163"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="330" mass="37043" checksum="BEF16DB398C39571" modified="2013-07-24" version="1">MGRLIDGDWHADVSNLATDDVPFEPDAFDGRIDADGPHPPDPERYHLYVSWACPWAHGTLLTRALLGLDDEIGISVVDPHRQDDGWEFTPEKDGCTPDRIGGNDFLREVYTDADPTYTGRVSVPLLWDEEAGTIVNGESDEIMRMLAAAFGDRAPNDENADVDLYPEARRAEIDEAIEALYGPINRGVYYAGFADSQSDHEAAVETVFDALDHWESVLADQRFLLGDRLTLADLRLFATLVRFDAVYYTHFGVNRKRIVEYQNLWGFTRDVFQTGTVARTVDLDQIKAHYYRSHEELNPSGFVPVGPELDFAAPHDRDRLADRDPLGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I4</accession>
    <name>R4W9I4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ORF">L593_07995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446438.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07995"/>
    <dbReference type="EnsemblBacteria" id="AGN01544">
        <property type="protein sequence ID" value="AGN01544"/>
        <property type="gene ID" value="L593_07995"/>
    </dbReference>
    <dbReference type="GeneID" id="16182221"/>
    <dbReference type="KEGG" id="sali:L593_07995"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1638"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_2"/>
    <dbReference type="OrthoDB" id="90817at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="225" mass="24007" checksum="6549C9D1D7274330" modified="2013-07-24" version="1">MTVAVIRFGGSNCDRDALRALEHLGADAEIVWYEDGLPEDTTGIVLPGGFSYGDYLRAGAMAARTPIMEEVREAAANGTPVLGICNGAQICAEKGLVDGAFTVNESARFQCEPVHLRVENADTPFTRGFEEGDVIRLPIAHGEGRYEAQPDAFDALIEEGKVLFRYCDAEGTVTEEANPNGSKDNVAGVVGEAENRAVLMPHPERAVLPELDGTDGRTILEGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J1</accession>
    <name>R4W9J1_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01574.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01574">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="549" mass="55184" checksum="9325DF92EFA0357D" modified="2013-07-24" version="1">MRSGDTIVEPGADRRAAPRPVPGSSPTSEPAGGGLLGPVRAGPGYSPWKDPTVLLLLVISLVAAALFVGGATFGPALSGGGGGGVFPVIDILTGDDGGDGTSLSLEANRSELQIGEPVAFTVTDGNDTPARNASVSIGGATYAADESGRVVVLIDRAGQLSATATAPGANDSTRESNEVAISVAPRPVQLAVRANRSVATAGEPIALTLVRDDIGTAVRGSIATRFVAEGDHLPAGGIQRHNGSQSVVVPDRAGRLIVVGTREDSGGETYHAHVGTVAVERRTVGLDVSVAPSEIVAGESVTATVRRADTDQPVAATLTVGSRTIETGVDGRAAVPFDAADTATIRATAAQTPAVSFAPGEARVTVERREVPLALSVAPAAITDGGRVTATVTRTDTGEPIEGTVTVAGQSVQTGSNGTATVEVASPGQVEIVASAPDTPTETFTSAAETITVPNATIDLDLLDAPASVAPGESFSIEVRATNRGPEAGTDTLRFQAGAETVADRTVSLAPGNRTVLSFETTAPDAPDELVVGVRGSDGSIEATIDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9J6</accession>
    <name>R4W9J6_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_08195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01584">
        <property type="protein sequence ID" value="AGN01584"/>
        <property type="gene ID" value="L593_08195"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08195"/>
    <dbReference type="eggNOG" id="arCOG06252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200151_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6353" checksum="7C18070F95E8CDE7" modified="2013-07-24" version="1">MVDPTSDLGEDVDPEDAPTCETCGDSILQDPEHVVETWVEDGTVQSRHFCSQDCRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9P2</accession>
    <name>R4W9P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14545"/>
    <dbReference type="EnsemblBacteria" id="AGN02848">
        <property type="protein sequence ID" value="AGN02848"/>
        <property type="gene ID" value="L593_14545"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14545"/>
    <dbReference type="eggNOG" id="arCOG07561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184183_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10219" checksum="1E018F23B3D3E5C3" modified="2013-07-24" version="1">MSWTHKQRVTVVAMVVLVVAVPALWQIGDVRAAQATEQKQSDLVDQTVSTRQAPTDYDGDGINDTADTCPTRPETNNGFRDVDGCPDVVETTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9X9</accession>
    <name>R4W9X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psmB</name>
        <name evidence="9" type="ORF">L593_10195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10195"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="AGN01984">
        <property type="protein sequence ID" value="AGN01984"/>
        <property type="gene ID" value="L593_10195"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2101"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="4 6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5 6" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005079686" description="Removed in mature form; by autocatalysis" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023449054" description="Proteasome subunit beta" evidence="6">
        <location>
            <begin position="49"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="243" mass="25345" checksum="B925053E0B0C63F2" modified="2013-07-24" version="1">MDDARGRDGLVPDGSTSDPDPFAPELVPNDAVGDATQHHDDETVNKTGTTTIGISTEDGVVIATDRRASLGGRFVSNKRVQKVEQIHPTAALTLVGSVGGAQSLIRTLRSETSLYGTRRGEDLSIPALATFAGNVMRGGPFFATHPILGGVDEDGSHVYSIDPAGGVLEDDYVVTGSGTQLAYGAIEGEYDPELSIEEAVTLAARGVHAATERDTGSGNGIYVATITDDGVDIEDYDDVAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y1</accession>
    <name>R4W9Y1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1724 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10245"/>
    <dbReference type="EnsemblBacteria" id="AGN01994">
        <property type="protein sequence ID" value="AGN01994"/>
        <property type="gene ID" value="L593_10245"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10245"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013561">
        <property type="entry name" value="FilR1_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08350">
        <property type="entry name" value="DUF1724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1724" evidence="2">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="32453" checksum="40588F46B9358597" modified="2013-07-24" version="1">MFRRQEPPVMTGAVAFVLGSEARREVLARLADCDDSGRGIVAACDASESAVYDALGRLEDRGYVEETSEGAWRLTGAGRLVADTVERCERLDCVIGGDAEYWAAHDPTGLPAEFRRTIDRLECCEVVRSPDTDPYRAARRVERAIESATTVAIVAPIYSDRHAEALLETDAERRRLIMTPGMVDRLLEDEPAGPDTELGDLQIRVQPASISMTVTDGSLLFSLPTPDGSFDATSEVVAEGDAAIEWGRRLFEHYWERGTPVGQWIADEHPEALASENVHAPDVPDEVAGERSPEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA40</accession>
    <name>R4WA40_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447183.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11730"/>
    <dbReference type="EnsemblBacteria" id="AGN02289">
        <property type="protein sequence ID" value="AGN02289"/>
        <property type="gene ID" value="L593_11730"/>
    </dbReference>
    <dbReference type="GeneID" id="16181125"/>
    <dbReference type="KEGG" id="sali:L593_11730"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2414"/>
    <dbReference type="eggNOG" id="arCOG01002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053687_0_0_2"/>
    <dbReference type="OrthoDB" id="47009at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="131"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="372" mass="39977" checksum="6A036C32AD2F5D3F" modified="2013-07-24" version="1">MPDLDARADRLDAYLDAADLEAVWFARPNGFAWLTGGSNVVDRDGDVGVAAAGYDGEFRVLTDSIEAQRIADEEVPDAFEVERFTWYESDLGAALADRSPSPAAADFDVPGFEALQASELRQPLTDDDVERYRALCADTAEAVEAVCRRLEPTTVEADGATDLTAELRRRGIEAPVALVGGARRAQAYRHYTAREDELGEYALVSVTAQREGLYASTTRTVAFDPPSWLAERTRKAARVEATALAATQAAATGEYPRNADGSGTAGDVFGAIQEAYAAVGYEGEWELHHQGGAAGFAGREWIATPEATDPVHAPMAYSWNPTVQGAKSEDTQLVTANDVEPLTITGDWPTTTVESVELPGVPTVELERHVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA79</accession>
    <name>R4WA79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12725"/>
    <dbReference type="EnsemblBacteria" id="AGN02484">
        <property type="protein sequence ID" value="AGN02484"/>
        <property type="gene ID" value="L593_12725"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12725"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2611"/>
    <dbReference type="eggNOG" id="arCOG02788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="465" mass="51041" checksum="29F5D0E0BCB837D7" modified="2013-07-24" version="1">MDSLRADALGAYDPDRRTPIMDELAADGTLFEHAYATGNWTPFSFPSMLASRHVFEGDGSIGVDAGTTLASVLSEAGFDTAGFNAANGFLSSHWGYDAGFDEFDSFVANVGDGLYGRYLATHPTVEAWLQVATAPFRRVGKVVRRQTDDRPFLDTARMFDVEHAATDFLEDAGEDDDPFFLWVHYMDVHTPYVPAKRYVKEVTDSRLGLHRKLLAHTYTGLGWEVGDRTLEDLRTLYQATVRQVDASIGRLLDTLDVVGHADDTAVVLAGDHGEEFQEHGHLSHYPKLYDELMHVPYIVDVPGAESRRIEQQVGLDTIPPTAAELVGVEGHPDWRGTSLVPTILDGETPPNEPVISVTVRGETVTTQPIPRTLDDGDLLVSVRDGPWTYIENVETGETELYDRRADPTQQTNLADDPTPEQRDVIDRLASIAEAHVTTLGDGGDAAGDDEVDDAVEARLTALGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA89</accession>
    <name>R4WA89_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447428.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02534">
        <property type="protein sequence ID" value="AGN02534"/>
        <property type="gene ID" value="L593_12975"/>
    </dbReference>
    <dbReference type="GeneID" id="16180340"/>
    <dbReference type="KEGG" id="sali:L593_12975"/>
    <dbReference type="eggNOG" id="arCOG09396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444730_0_0_2"/>
    <dbReference type="OrthoDB" id="80601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006793">
        <property type="entry name" value="FaeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04703">
        <property type="entry name" value="FaeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="187" mass="21434" checksum="5104F5C4251B041C" modified="2013-07-24" version="1">MSENEERAWGQYAETVPDERALAVFTGAEPHTTREVAEAMNVTEHTARTALETLHERGDVGRKTVRDEPATLTVWYRSRTAIGDEPEDVETVDVDARVDELLADVEVPGTSEMMRDWRVDAIRASFDHLREQEAVSVDEFFEDVFPAHQAGFDDPEPWWELVRPRLRRLPGVVNPAWGEDVWRYEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD9</accession>
    <name>R4WAD9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447678.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14225"/>
    <dbReference type="EnsemblBacteria" id="AGN02784">
        <property type="protein sequence ID" value="AGN02784"/>
        <property type="gene ID" value="L593_14225"/>
    </dbReference>
    <dbReference type="GeneID" id="16181152"/>
    <dbReference type="KEGG" id="sali:L593_14225"/>
    <dbReference type="eggNOG" id="arCOG01224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180506_0_0_2"/>
    <dbReference type="OrthoDB" id="126162at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11303" checksum="1ED15A7FDCFE7AE6" modified="2013-07-24" version="1">MTGNSDDTDDLEAGFREKTGQYEALLAEALAVATVAEDLPESQRDAAEQCLEMAEAYLRDGRHFRETDDLPDALAAFSYGHGWLDAGARVGVLDVPSEGHLFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSB1</accession>
    <name>R4VSB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00750"/>
    <dbReference type="EnsemblBacteria" id="AGN00105">
        <property type="protein sequence ID" value="AGN00105"/>
        <property type="gene ID" value="L593_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00750"/>
    <dbReference type="eggNOG" id="arCOG04569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110566_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043821">
        <property type="entry name" value="DUF5799"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19113">
        <property type="entry name" value="DUF5799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="183" mass="18925" checksum="7A355A9B4BE7340C" modified="2013-07-24" version="1">MTAWTDQFVGDRMAVDREFTERVAASEFSSQEWGTIMTAVEFEIEDPESPEQARVVADTSKVDQVLPAIESMREGMGMGGAPGAGGGGTNADGREGGAGSGSGLFGSIKDSLGLGGGGDEADHRAESAAALAEEYAQRFQEHLEEHGKWTRACEVAAATGDASRGEHAEESGGGVGSADEQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSI0</accession>
    <name>R4VSI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoamine oxidase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445059.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01060"/>
    <dbReference type="EnsemblBacteria" id="AGN00165">
        <property type="protein sequence ID" value="AGN00165"/>
        <property type="gene ID" value="L593_01060"/>
    </dbReference>
    <dbReference type="GeneID" id="16182384"/>
    <dbReference type="KEGG" id="sali:L593_01060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.217"/>
    <dbReference type="eggNOG" id="arCOG00774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_0_0_2"/>
    <dbReference type="OrthoDB" id="106288at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="147" mass="16327" checksum="4227FAD64058C028" modified="2013-07-24" version="1">MSGGYDAVEVGDTATTAGRTITEADVANFAGVSGDFNHLHLDAETMAATEYGERIVHGALVFSVATGLLWQHRDDDIREHVVAFYGVDRLRFVRPCFIGDTLHVVREVLEKERREHPVATGIVRYEITVLNQRDETVLAAEFLSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSR0</accession>
    <name>R4VSR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445104.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01285"/>
    <dbReference type="EnsemblBacteria" id="AGN00210">
        <property type="protein sequence ID" value="AGN00210"/>
        <property type="gene ID" value="L593_01285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182763"/>
    <dbReference type="KEGG" id="sali:L593_01285"/>
    <dbReference type="eggNOG" id="arCOG06366">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2216981_0_0_2"/>
    <dbReference type="OrthoDB" id="127823at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11239" checksum="78A48B320CB65AB3" modified="2013-07-24" version="1">MSLLTGIGVAVIVAIHTVVAVVLTRFFRLQLDTNWGAAAYTLVLVPIALIVSATVLSGVLGLGGNVGGRDVVLLLVIALPLSLGITIDYFWMPAPEEIELPAETTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSW7</accession>
    <name>R4VSW7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">L593_01635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445174.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01635"/>
    <dbReference type="EnsemblBacteria" id="AGN00280">
        <property type="protein sequence ID" value="AGN00280"/>
        <property type="gene ID" value="L593_01635"/>
    </dbReference>
    <dbReference type="GeneID" id="16179894"/>
    <dbReference type="KEGG" id="sali:L593_01635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.332"/>
    <dbReference type="eggNOG" id="arCOG01894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_2"/>
    <dbReference type="OrthoDB" id="50501at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="29628" checksum="533662380CDFA8B6" modified="2013-07-24" version="1">MKIGAHVSIAGGVDNAVDRQLDVGGNCGQIFTTSPQVWQEPSIDEEEAASFREQTAEKLEGPWLIHSSYLVNLATPKDDLREKSIASMQAELDAAERLGVQYVNVHLGAHTGAGVEGGLDNAAETLDALDVPDGVQILVESDAGSGTKLGGEFEHLAGVLDRSEQDLGVCLDTAHSFSAGYDLSTEDGVEEAVAEFDDVVGLEHLKALHLNDSKHGRGTNKDEHAHVGEGEIGVEGMTAVLSHPELRDLPFVLETPTENGKSFEWNVDRARELQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT52</accession>
    <name>R4VT52_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="8">GAPDH</shortName>
            <ecNumber evidence="8 10">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gap</name>
        <name evidence="13" type="ORF">L593_02145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8 10">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="8 10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445274.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02145"/>
    <dbReference type="EnsemblBacteria" id="AGN00380">
        <property type="protein sequence ID" value="AGN00380"/>
        <property type="gene ID" value="L593_02145"/>
    </dbReference>
    <dbReference type="GeneID" id="16180086"/>
    <dbReference type="KEGG" id="sali:L593_02145"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.435"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OrthoDB" id="32079at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="357" mass="37494" checksum="F0DA7C70BF79DF66" modified="2013-07-24" version="1">MVGVGVNGYGTIGKRVADAIAAQPDMTVAGVAKRSPDAGARSALAKGFSLHAPADRMDRFRDAGVPTDGTVEDLIAASDVVIDATPGGVGEQNAPLYDAHDTPAIFQGAEDPSVAETSFTARANYADAVGADRVRVVSCNTTGLSRLLTPIDETWGIERVRVTLVRRGGDPAQPDRGPIDDILPDPIEVPSHHGPDVQTVLPELDIDTMGVTVPATRMHLHAVSITLEDDLDGDLAPEAIRDRLAGQSRLFLVPGDLGVESCGGLKEVAKDAGRPRGDVWENCIWTDSIAVSDGELYCFQAIHQEADVVPENVDAVRAVAGLADGPRSRRLTNDALGLEDSPAAVDHPVRDVGTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VT68</accession>
    <name>R4VT68_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00400">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="126991at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="102" mass="10968" checksum="304966CC0ACD1143" modified="2013-07-24" version="1">MSNRVEELETTVSALESTIEGLTEELVETKERLRVIESKLDVDAADVVQETPIREAPAEDGPTTEAAPDEVEQAVEADKEAESEEPAETEGTGELGDDIIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTN8</accession>
    <name>R4VTN8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">L593_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445494.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03245"/>
    <dbReference type="EnsemblBacteria" id="AGN00600">
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    </dbReference>
    <dbReference type="GeneID" id="16180347"/>
    <dbReference type="KEGG" id="sali:L593_03245"/>
    <dbReference type="eggNOG" id="arCOG06011">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="108427at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
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        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4382" evidence="2">
        <location>
            <begin position="43"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
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            <begin position="72"/>
            <end position="215"/>
        </location>
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        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="379" mass="38797" checksum="36F50ACD95ADB982" modified="2013-07-24" version="1">MRLTGGLAAAATAGLAGCSSSVPGTGDGDGSGSGGGTGDSSATGLLSTAVSDNPGDIGDFESCIVTIDGIWVGPEVSGSDGDGEVEDGENETEVEDGENDTEVEDGENETDAGEEDGGPPEDSPGGSDQQSSGDEASGSQDDETETTENTTEDDGNVTDAEPPEDDDDGENETEDDEEEAEAEEEDEAEDEEAGDDDEAGEADGNGRTYYEFDESQEADLTQLQGEAQQLVGEHELSVGTYQFLQLDIGGIRGTLTDGSEASVETPGNAPLKFNESFDVREGYRTTFLADFTPVKRGNGSFLFQPVASETEVSYEEIESGSSDGSTDDGNTTDGDGGNTTDSDGENTSDGDAGNTSTTDDSNATATDDDNASDDGNQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTT9</accession>
    <name>R4VTT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445539.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03470"/>
    <dbReference type="EnsemblBacteria" id="AGN00645">
        <property type="protein sequence ID" value="AGN00645"/>
        <property type="gene ID" value="L593_03470"/>
    </dbReference>
    <dbReference type="GeneID" id="16180570"/>
    <dbReference type="KEGG" id="sali:L593_03470"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.704"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_4_0_2"/>
    <dbReference type="OrthoDB" id="36958at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="35793" checksum="B10EB0C91D5B9E16" modified="2013-07-24" version="1">MDAIVLAGGYATRLWPITRHRPKMFLPIGESTVIDRIFEELEADDRIDDVYVSTNERFAEEFEIHLEESSFEKPQLSVEETTEESEKFGVIGALAQLVDRERLTDDTLVIAGDNLISFSVSEFVDEFQSVGTPTIAAYDVGSRDRATSYGVIDVDDGRVVDFEEKPEQPASTLVSIACYGFPADTLGLLQTYLAGDNNPDEPGWFVQWLVDRERVNAFTFDEAWFDIGTPDSYLDAVSWYLDGGQLVHPSATVENSDLGENVHVMADAEIVDTELERAIVFPEATLHSCEIRSSIIDEETVLENLNLAGAQIGAHTRIANGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUC1</accession>
    <name>R4VUC1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">L593_04245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445694.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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        <location>
            <begin position="57"/>
            <end position="248"/>
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            <begin position="65"/>
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</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="79" mass="7966" checksum="BB73AEB0876BFFA8" modified="2013-07-24" version="1">MSPGRIKRALSRARYAAIGAAIGGGLGGLFSRSAASSGAAMGAMLGAAFGETRLSARERIDGVKSKSARGVDRIRPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV05</accession>
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            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
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        <property type="entry name" value="DHH_sf"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AGN01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="366" mass="40744" checksum="C304F47CEC7866F3" modified="2013-07-24" version="1">MDDDLIDDRDLSPERRSLLPGEGFFVPDSFEEELEAQEAAEALAGVSVAVVADPDADGLACVALLREVYGEAALIPTGPHDLEDGMEYVAEYGEDDLRAFVCDLSPDRFEYVEEELAALVETASEVRWFDHHQWDESVADAVRETGVDLVVGDSEEECTADVALRSLDYEFPAHLHELAAVTRDHDLWIKDDPRSDDISDYSYWVEDEETYVEVVREHGPDLPEETMAMLEERRVEKTDRIERALRRAEFREIGPWTVGITYGRCSQNEVAEGMREEGADASVIVKPSGPASIRGTDDFERAHEVAGKVNGGGHPKAAGCKPDVYEDMLDYAHHWTTQGAVCKQAIIDAFRTVAAEVDHDPDSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVM5</accession>
    <name>R4VVM5_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Muconate cycloisomerase</fullName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01250.1"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06515"/>
    <dbReference type="EnsemblBacteria" id="AGN01250">
        <property type="protein sequence ID" value="AGN01250"/>
        <property type="gene ID" value="L593_06515"/>
    </dbReference>
    <dbReference type="GeneID" id="16181700"/>
    <dbReference type="KEGG" id="sali:L593_06515"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_2"/>
    <dbReference type="OrthoDB" id="17973at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="134"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="43644" checksum="9B0ED02689D34CC4" modified="2013-07-24" version="1">MQIRDITAYPLQDDLWNPWCIVTVETDDGLRGVGEAGGLWANTDLYAKVEYAKKFDEWFEGMDPLNIESLRVKAQETAWGQSRISQAMLSGIEMACWDIAGKHYGEPVHKLLGGAIRTELPAYANGWYDGLETPEEWAEGAADVIDRGYDALKFDPYENSVRDIENDEMQLALDRIAAIREEVGEEPSLMIEGHARLTPGEAIKIGSRLEEYNPTWFEAPIQAHQGPDAFREVREALSIPISDDLASIENKFEAFEFISERAIDVIQPDAANVGGLREVQYIAQMADAASISIAPHAAGGPVAMTATVHLDAVLPNFKIQEGFNEFTRPDWVTDVIEDPISIEDGTIDVPEEPGLGIEFDADLAEEHDCNPMPDHNFLSSEFKDTYGSQEHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVV2</accession>
    <name>R4VVV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446229.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06940"/>
    <dbReference type="EnsemblBacteria" id="AGN01335">
        <property type="protein sequence ID" value="AGN01335"/>
        <property type="gene ID" value="L593_06940"/>
    </dbReference>
    <dbReference type="GeneID" id="16179876"/>
    <dbReference type="KEGG" id="sali:L593_06940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1418"/>
    <dbReference type="eggNOG" id="arCOG02827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510581_0_0_2"/>
    <dbReference type="OrthoDB" id="71764at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="434"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="493"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="543" mass="59041" checksum="A379567BF0367403" modified="2013-07-24" version="1">MANDGVFGGWYRTHLGEPLEPDHVNGYWAFLFGAFLALVGLVLFLVAAGYERGSDNFWLFRRVAFTLALVAGPIVVLSIVYLLPLQARAAWLATLGLLLCVGAAIAFNVYYPDDWNWAGDMSPVIMGGYGAGIALQILTIFLYPLVSSGTAQPDVLPASEADDGAEAAAAASAADTSKATFQLYEDRASEHRWRLVHDNGNVIADSGEGYASRQKARQGMSSVKQNAPGAEEEILERVPEDAPAEATASEPAMVAEDGGEDAASPTAATDDAGDDDADDDGTAFEFGPTDDAASDDTATDEAAVNDEATDDASADATFEVYEDNVGEYRWRLRHSNGNVIADPGEGYSRRSAVNEAVERIKRVASEADTLEYEPAAFELYADAADEWRWRLRHRNGRILADSGEGYASRRNAKDGVESVRKHVADPENVEVYEDNAGDYRWRLTASNGELIADSGQGYSRESRAQDAVERVSEYAPEADTLDYEPAAYEVFQDNAEEWRWRLRHRNGQILADSGEGYASKQKARQGMHSVMNNAPAAEIEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW04</accession>
    <name>R4VW04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445340.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02475"/>
    <dbReference type="EnsemblBacteria" id="AGN00446">
        <property type="protein sequence ID" value="AGN00446"/>
        <property type="gene ID" value="L593_02475"/>
    </dbReference>
    <dbReference type="GeneID" id="16180228"/>
    <dbReference type="KEGG" id="sali:L593_02475"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.502"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_3_2_2"/>
    <dbReference type="OrthoDB" id="21012at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="335" mass="36799" checksum="A7C0A6FA38F57852" modified="2013-07-24" version="1">MHLGTGLFTCQKRPDDDRTTAEIYDEMLDLAGVADDAGLDSVWVSEHHFQSDDYLSGVTPALGALAAATDSIEIGPCIALAPLYDSVRLAEDVATIDQLSGGRATLGLAIGSNPREFEEFGVPKDERVDRLEDAVAVCRTAWSDGPLEYDAEFHDVSEEVDVTPKPAHDVPVMLGGAAKPAVRRAARIGDAWCAPSALSVEGVAKRVTDIESVREEEEGIEGEFDVYVIVHGFVGDSREEAWNAMRPGYFYLQRRYQEIFSGEPVDELDPDRKQELKQQAICGTPEQVTEDLESYREAAGDDVHVIFRAYHPGIGTERMAECVRRLGTEVRPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW27</accession>
    <name>R4VW27_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="5">BCAT</shortName>
            <ecNumber evidence="5">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ilvE</name>
        <name evidence="6" type="ORF">L593_07375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446314.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07375"/>
    <dbReference type="EnsemblBacteria" id="AGN01420">
        <property type="protein sequence ID" value="AGN01420"/>
        <property type="gene ID" value="L593_07375"/>
    </dbReference>
    <dbReference type="GeneID" id="16181849"/>
    <dbReference type="KEGG" id="sali:L593_07375"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1506"/>
    <dbReference type="eggNOG" id="arCOG02297">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_2"/>
    <dbReference type="OrthoDB" id="41340at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="309" mass="34866" checksum="65AAA78AACC399C8" modified="2013-07-24" version="1">MGFEDMDVDTIWLDGEFVDWDEAQIHVLTHSLHYGTAVFEGIRCYDTEEGPAIFRWDSHVDRLYESAKPLELDIQHEPEELREATEQLIRDQDLPSCYIRPIVFYGYDSLGVSPKDCPTRTAIAAWPWGAYLGEDALENGVDVMISSWRKHHPSQIPTNVKATGPYINSMLAGEEARRNGYVEAIVLNKDGQVAEGPGENLFLVRDGEIFTPGLSESILEGITRESIIQIARDLGYTVHDQASISRGELYTADELFFTGTAAEVTPIRTVDDVEIGSGTRGPVTEELQQTFFDVVERRTDEYDDWFSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWD0</accession>
    <name>R4VWD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07975"/>
    <dbReference type="EnsemblBacteria" id="AGN01540">
        <property type="protein sequence ID" value="AGN01540"/>
        <property type="gene ID" value="L593_07975"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07975"/>
    <dbReference type="eggNOG" id="arCOG06432">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656823_0_0_2"/>
    <dbReference type="OrthoDB" id="131416at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16712" checksum="4E610F32A5003E1F" modified="2013-07-24" version="1">MERRKVLRSIGSVAVLGVAGCSSQFTSRPKLDLSVENYRDVAAELFIEVVARDASNRSDGVMYQEWVEVPANSVGDDQWRLDDFATARPCRIEVRVRNRERGAKTYHYHYVPDCTDDDAQFDPRVDLVLDPHSGLSFGQTTCSGTVASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWD9</accession>
    <name>R4VWD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445490.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03225"/>
    <dbReference type="EnsemblBacteria" id="AGN00596">
        <property type="protein sequence ID" value="AGN00596"/>
        <property type="gene ID" value="L593_03225"/>
    </dbReference>
    <dbReference type="GeneID" id="16180464"/>
    <dbReference type="KEGG" id="sali:L593_03225"/>
    <dbReference type="HOGENOM" id="CLU_2393022_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9499" checksum="1241E611E50720E6" modified="2013-07-24" version="1">MNGTSSRSIGHVVGRALLAFLDALVAGSAAALAAWFAVPVVWVSTRLELVALVGGLVTGVVLAVALALAGRGQRPFPATRLAKGALDRVPLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWR4</accession>
    <name>R4VWR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_08675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446574.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08675"/>
    <dbReference type="EnsemblBacteria" id="AGN01680">
        <property type="protein sequence ID" value="AGN01680"/>
        <property type="gene ID" value="L593_08675"/>
    </dbReference>
    <dbReference type="GeneID" id="16182501"/>
    <dbReference type="KEGG" id="sali:L593_08675"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1778"/>
    <dbReference type="eggNOG" id="arCOG00332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_2"/>
    <dbReference type="OrthoDB" id="44343at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="780" mass="85980" checksum="D6F4FC34811EB331" modified="2013-07-24" version="1">MTFWAAGTAVLQSGDDVTRPTFFEISHVGEILFYLLAAIAIGIFVRGVYLRVSRWTRGREDPRDRLANLPGRIRRAVTDIGSNAPLFDRDPYAGVMHTFLLWGFLTLFVGTSILAIDMDVIQPLMDTSFWTGDFYRAYEVVMDAMGLLFVVGVAMAMYRRYWIRSERLWGPRVSVADDAFVWTLFVLGVGGFLLEALGILGRGVPDFEVVSFVGYGLALAFEGAGLTAEDAATIYPAVWWIHAFHALAFIALIPYFKAFHMLSSFANVVAQDDEAGARLPGIPADLDHENATDVDHFTWKEQLDQDACTNCGRCSSVCPANASGRPLDPRNVILDLKNYRESLEDGGPERPIVGEFDGLRADGGTMADGGTMTDGGAATADAGGATGDPEPGIPEHASPTTAGTNREPVEPDEDDAVIDRDAMESCMACMACMDACPVEIEHLTSFTRMNRQLVDEGAVDPNVQDVFQDVMQKGNSFGESQSKRADWADPLDLEPTDAREESVEFLWYVGDFPSYDDRNKQVARSLAKLFDEAGVDWGIVYDDEKMDGNDVRRIGEEFLFLELAGHHVETFEDCEFETIVCTDPHSFNTIKNEYPEVDFGEFADDPVMPFEFDEQWNADGEIDVKHWTQVLADLQARGDLGLAGDELDYTVTFHDPCHLGRYNGVYEPPRDLLTAAGCDLHEMPRNRSDSFCCGGGGGGVWTEHDEETKPSEERLREANQDTAAGDAVEKFVVACPLCTTMFEDGRKTGGFEDDLDVVDVAELLVEALGLEDAREDANGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX07</accession>
    <name>R4VX07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_04225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445690.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04225"/>
    <dbReference type="EnsemblBacteria" id="AGN00796">
        <property type="protein sequence ID" value="AGN00796"/>
        <property type="gene ID" value="L593_04225"/>
    </dbReference>
    <dbReference type="GeneID" id="16180874"/>
    <dbReference type="KEGG" id="sali:L593_04225"/>
    <dbReference type="eggNOG" id="arCOG01685">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068197_0_0_2"/>
    <dbReference type="OrthoDB" id="66988at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="223" mass="23463" checksum="7643BED6406A2453" modified="2013-07-24" version="1">MKDLAQLQAPVEADHGPPRVLDLTGERADEVFSALSSATARTILSALYEEPKPASQLVGETDTSLQNVQYHLDRMQDAELIEVADTRYSEKGNEMCVYAPTDAAVVLCGSEQSATDRLRDAAPRLLGAVGVLGGASLGVQFLWTEYVVATGSSGGSAEQPMTMDTTSTAASSAGSETPLLAEPGVVFFLGCLAALLLVGIALLARRRYADRQSGSDRPATTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXH5</accession>
    <name>R4VXH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ORF">L593_05060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445855.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05060"/>
    <dbReference type="EnsemblBacteria" id="AGN00961">
        <property type="protein sequence ID" value="AGN00961"/>
        <property type="gene ID" value="L593_05060"/>
    </dbReference>
    <dbReference type="GeneID" id="16181250"/>
    <dbReference type="KEGG" id="sali:L593_05060"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1033"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_1_0_2"/>
    <dbReference type="OrthoDB" id="95578at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGN00961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="44277" checksum="16882A94B30DA428" modified="2013-07-24" version="1">MEERTRAYLRGRFRDHYRRAELTMPPLAERREWGYIPWSSGGTTMVRHQSLLELGAVESFLERERPRHVYFSAGVYHDPGANAMEAKGWRGSDLVFDLDADHLPGVDPDTTSYADMLEACKDALFKLLSFLEDDFGFEDLTIAFSGGRGYHVHVRDDGVRTLDREARREIVDYVRGVDVTADRVVDTETVVGEAGRTSPADKRTLDTSGGWSARVHRRVVDLVEELEAVDEATAKERLQSFEGIGAGRSEAIANAIAENAGAVRAGNVDVHGSFKGLVEALVEETVAEESAPIDEPVTTDTHRLIRLPGSLHGGSGLAVTRIDREDLADFDPMVDAVPETFRGNEIHVEVTDLSGLAPFEDDQLGIVEVGGDSFSVGPGTQLLPEPVAIFLMTRDRAEKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXM0</accession>
    <name>R4VXM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446899.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10300"/>
    <dbReference type="EnsemblBacteria" id="AGN02005">
        <property type="protein sequence ID" value="AGN02005"/>
        <property type="gene ID" value="L593_10300"/>
    </dbReference>
    <dbReference type="GeneID" id="16182418"/>
    <dbReference type="KEGG" id="sali:L593_10300"/>
    <dbReference type="HOGENOM" id="CLU_1850719_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="13723" checksum="CBDE4951D2486F73" modified="2013-07-24" version="1">MTRHSVLVGLVVLCTIAIPLTGGALAAGTDAGGPSIASVQDDSMGNDSMENDSMQNDSMDDGGTNDAMDGADSMDSDSMDSDDSMDGDSGMNEEDGMDEDSMDDSGGSDDGLSTLQLGALAVGGLAVLGGVGIYVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXQ1</accession>
    <name>R4VXQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445935.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05460"/>
    <dbReference type="EnsemblBacteria" id="AGN01041">
        <property type="protein sequence ID" value="AGN01041"/>
        <property type="gene ID" value="L593_05460"/>
    </dbReference>
    <dbReference type="GeneID" id="16181362"/>
    <dbReference type="KEGG" id="sali:L593_05460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1114"/>
    <dbReference type="eggNOG" id="arCOG01670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167520_0_0_2"/>
    <dbReference type="OrthoDB" id="100749at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12537" checksum="3E4CD678AA28426D" modified="2013-07-24" version="1">MTKAAVVILAGTEGHANLGRIVNGLETAKEFAETDGDEVELIFDGAGTQWIAELEDPDSDQHELYQAVRDDASACDYCSGAFGVDDAVNDSGVVRLDDNGGHPSIQSLVDDGYEVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXR5</accession>
    <name>R4VXR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">sn-glycerol-3-phosphate dehydrogenase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpC</name>
        <name evidence="8" type="ORF">L593_10550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10550"/>
    <dbReference type="EnsemblBacteria" id="AGN02055">
        <property type="protein sequence ID" value="AGN02055"/>
        <property type="gene ID" value="L593_10550"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10550"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2175"/>
    <dbReference type="eggNOG" id="arCOG00966">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_7_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017753">
        <property type="entry name" value="G3P_DH_GlpC_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03379">
        <property type="entry name" value="glycerol3P_GlpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="522" mass="56372" checksum="A1DC0DC2AD4D84F5" modified="2013-07-24" version="1">MHGQPPAGDDSADGDDDRCDHGCAEDAAHRSADPAGGDSAQNAADSADGDAPAPATDGGESPGARRTSSEPRSDGGVDSGVPGEVGSTAAASAGAEGTDEFDPVEVFPESDEMDLRPGADSCYKCSTCDTNCPVAEVDDEFPGPKFQGPEQWRLSRSDAPEVDPSIEKCSNCMRCDHACPTDVPLSQMHNTARGKYVDDQLSPYSRTYIRKKLLSNYGRLGRIGAMVPRLTNVALSNRALRWVGDKVLGITNEREFPEFADQTFRSWWEERGGAQVESRRRRVAYFHGDYANYNTPEVGKALVKVFEDFGYEVAVPRQRCSGTPMFANGMLDDARRAAEVNVSEFASLIEEGYDVVCSCTSCSMALRQEYPELFDIEGIDRVAANTYDAVEYLRINEDLSAALSKSDADVPDVAYHAPCHARNQGLADQALEVGASIDGVQVQDVGDSCSGISGTYGWKSKHYDTSMAIGEEMFEHMESADADTGMTECPTCAMQMEHGTGYEVNHTLQLIAVALDLEGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXW5</accession>
    <name>R4VXW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_10850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447009.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10850"/>
    <dbReference type="EnsemblBacteria" id="AGN02115">
        <property type="protein sequence ID" value="AGN02115"/>
        <property type="gene ID" value="L593_10850"/>
    </dbReference>
    <dbReference type="GeneID" id="16180059"/>
    <dbReference type="KEGG" id="sali:L593_10850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2239"/>
    <dbReference type="eggNOG" id="arCOG06312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998685_0_0_2"/>
    <dbReference type="OrthoDB" id="108535at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="125" mass="14376" checksum="2217B353C0D9C5DD" modified="2013-07-24" version="1">MHFDQRTQRALRDLGLDDEDLQDAAESIGTLVEADAVVLEEFFAQHDVVYSTMDQAHSADELPEHEVSHLDTYTHGDELRGWLRFDSWGAYVEDGRVLDEDHVELTLGPTVHDRIRFAPSRERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXZ2</accession>
    <name>R4VXZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446025.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05910"/>
    <dbReference type="EnsemblBacteria" id="AGN01131">
        <property type="protein sequence ID" value="AGN01131"/>
        <property type="gene ID" value="L593_05910"/>
    </dbReference>
    <dbReference type="GeneID" id="16181542"/>
    <dbReference type="KEGG" id="sali:L593_05910"/>
    <dbReference type="eggNOG" id="arCOG03006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144575_1_0_2"/>
    <dbReference type="OrthoDB" id="117358at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11295" checksum="753F7545DB3D3AF9" modified="2013-07-24" version="1">MSYDSVNYEDVEPAAPGMHFLRDALDAEQVGVTVLDADEGWSGLEHDHAEDGQEEVYVLVEGSATVTVEGEAVSMEAGDVLRIDPEATRSIDVEEESQFVLVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYF9</accession>
    <name>R4VYF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="9" type="ORF">L593_11760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447189.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11760"/>
    <dbReference type="EnsemblBacteria" id="AGN02295">
        <property type="protein sequence ID" value="AGN02295"/>
        <property type="gene ID" value="L593_11760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181018"/>
    <dbReference type="KEGG" id="sali:L593_11760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2421"/>
    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OrthoDB" id="17053at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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            <dbReference type="ARBA" id="ARBA00022540"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
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            <dbReference type="PROSITE" id="PS51722"/>
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            <dbReference type="EMBL" id="AGN02295.1"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
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    <sequence length="601" mass="65036" checksum="1805BB7134E57D44" modified="2013-07-24" version="1">MADTPTPEGGDEQLRTPIVAVLGHVDHGKTSLLDEIRGSAVAAGESGAITQHIGATAVPLDTISGIAGALVDPDDFDLPGLLFIDTPGHHSFSTLRSRGGALADIAVLVVDVNDGFQPQTEEAVDILRRTETPFVVAANKVDTVPGWRPEEGAPIQQRYEAQSDRVRSMLDEGLYEIIGQLSDAGFSADMYWRVQDFQANVGVVPVSAETGEGIPDLLAVMMGLSQRYMREAMEIDTEGPGVGTVLEVKEEKGFGTTIDVVLYDGQLRPGDRIVVGGEDEPIVTDVRALLQPKPLAEIRTESRFEQVDSVSAAAGIKVAAPELEKAMAGAPLRAVRDRPVEEVIAEVQEELAEVAVATGEEGVVVKADTLGSLEAIANATEEAEIPIVRAEVGDVAPRDVAVAETADDPMHRAILAFNVDVLDDAAREAEDAEVRIFDDDVIYQLIEEYEEFVTAREEAQQEQILDNITRPARFQILPDHTFRQSDPAVVGVEVVAGTLKNNSTVARFTGSEPERIGELSGIQEQGEDVSEARRGDRVSVAIDGPTVGRQIDEGDELWTLIPEKHAKILEQELTDDLPGDEIEALNMYLEKHRKRDPFWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYM3</accession>
    <name>R4VYM3_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Nmra-like family protein</fullName>
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        <name evidence="3" type="ORF">L593_12085</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="268" mass="28542" checksum="2DE178632280CA52" modified="2013-07-24" version="1">MTRTLLTGATGTLGSELLPRLREAGHDVIAASRSPPTDSGGDDPIGRGSDSELEWVELDLGTGEGIEGAVAAADVIVHAASNATGDSEAVDARGTGRLVAAAEAADVSHLVYPSIVGVDEMTSFSYYEHKLAAEQAIREGDVPWTIVRATQFHEFVDELLGMVARLPIWPWVTRFRVQPIAAAEVAVAISEHADEDPVGYAAELGGSEVRTGRELAEAYRSARGYRRPIVRLPLPGKTAAAFRAGAATTPDRAVGKQPWEAWLAERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYS3</accession>
    <name>R4VYS3_9EURY</name>
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        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01391.1"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14085" checksum="37FAAFA65E98FEB4" modified="2013-07-24" version="1">MPRYSVGRILGLGGGGICVLGLVLATLGTLQIGGWRIAPLLGLLWPPTGLAIGAIGLRIAGSRASGDVLAVYGGMGAHLFALSLVLLTGGGWLLGGGSGRLVAAVAWGAAALLYGGFAYAWERTTPTDVDAAWRDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ36</accession>
    <name>R4VZ36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12955"/>
    <dbReference type="EnsemblBacteria" id="AGN02530">
        <property type="protein sequence ID" value="AGN02530"/>
        <property type="gene ID" value="L593_12955"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2656"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="538" mass="55762" checksum="426A95DA66914A01" modified="2013-07-24" version="1">MSSQQTRSPEANLGLLDATMIGMGAMIGAGIFVLTGLAADIAGPAALLVFGLNGVGTAFTGLSYAELAAAIPKSGGGYAFVRETFDDLASFLMGWMLWFAYMIAGALYALGFAPNFLELLHVYGLVAPPHEVGAIAIPMLDVGVPAGFALAFSAVLLFVALNAVSTAASGSVETIFTATKVTILIVFVAFGVASAQFTSAEFQPLFPEGTSATAIVPAMGLTFIAFEGYDLITTVTEEVENPRENIPKAIFVSLAATVVVYLAVVTVAIGTLGAGGLAEAGEAGIAAAATEFMPTGIPIIRNGGAIIVFGAVFSTLTALNAVVIAASRVAFSMGREGQLLPKFGQLHHRYGTPFVAILASAVVMLGSTLLPTQSAGNMSSLFFLLSFVVVNGAVIKLRRERPDMKRPYEMPFYPLPPILGILFNLVLTVVLVGYLVGTDPVALGLSTGWIALGVLAYYALKRRRNGSEPAVESGTIDDPTDGLDANATGDELIHATGSAGSPTESDHRRRSTDQGSEDAIPTDSDGDTDTTFGTEGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ58</accession>
    <name>R4VZ58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L593_13080</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447449.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13080"/>
    <dbReference type="EnsemblBacteria" id="AGN02555">
        <property type="protein sequence ID" value="AGN02555"/>
        <property type="gene ID" value="L593_13080"/>
    </dbReference>
    <dbReference type="GeneID" id="16182682"/>
    <dbReference type="KEGG" id="sali:L593_13080"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2681"/>
    <dbReference type="eggNOG" id="arCOG04694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_2"/>
    <dbReference type="OrthoDB" id="721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="364"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="643"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="683"/>
            <end position="690"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AGN02555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110938" checksum="E1A51E9FA739B612" modified="2013-07-24" version="1">MTEHIEVRGAAENNLADLDVDIPREEFTVVTGLSGSGKSSLAFDTVYAEGQRRYIESLSAYARNFLGQMDKPQVEKVEGLSPAISIDQKNAANNPRSTVGTVTELHDYLRLLYARTGTPHCPECGQPVGEQSASTMVSRLLELEDGTRAKIAAPVVRDQKGAFEDLFEELKADGFGRVEVDGEEHDLTMEIPELDENYDHTIDVIVDRVKLDPADRSRIADSVETALDRADGVLKVILPDAPDGAADSLGSRARSTGDLAGGADHDHTEIEAVDADAEEVDEAATDDRLVVELSEELACTDCGIDLPEIETRSFSFNSPHGACPECEGIGETKEVSEDLVIEDPSKPLKHVFEPWSFNRTYYRRRLQSVAEHFDVPLTTPFEDLPDEVQDAFLYGTYEDVVFEWTTSNGTRHKEQPFEGVIPNLERRYVETDSDGTRDHIEEYMSITTCPECEGTRLKPVSRAVLVDDTSITEVNRMSIGDALAHFEGMEEGMSARDRTIAEEILKEIRARLGFMCEVGLDYLTLDREASTLSGGESQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNDRLLNTLEELRDLGNTLLVVEHDTETMRRADTVIDLGPGPGKRGGEVVVHGDTEDVKACEESVTGDYLSGRRQIPVPDERRESDGELVVEGARQHNLRDLDVEFPLGNLVAITGVSGSGKSTLMHEVLYKALAREMHGNTEVDPGEHDGVEGYDDVETIRMIDQSPIGRTPRSNPATYTNVFDHIRELFAETELAKRRGYEVGRFSFNVKGGRCEECGGQGTVRIEMNFLSDVHVPCEECGGARYNAETLDVEYKGKTIADVLDMTVEEAYDFFEHDSRIERRLKLLKDVGLTYMKLGQPSTTLSGGEAQRIKLAEELGKKDKGDALYLLDEPTTGLHPEDERKLIEVLHRLADRGNTVVVVEHELDLVKNADHVVDLGPEGGEAGGDVVAAGTPEEVARTEESHTGRYLRDLLPDVELDGPRADREEAAAPAADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ93</accession>
    <name>R4VZ93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446470.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08155"/>
    <dbReference type="EnsemblBacteria" id="AGN01576">
        <property type="protein sequence ID" value="AGN01576"/>
        <property type="gene ID" value="L593_08155"/>
    </dbReference>
    <dbReference type="GeneID" id="16182317"/>
    <dbReference type="KEGG" id="sali:L593_08155"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1673"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_2"/>
    <dbReference type="OrthoDB" id="47457at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="154"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="313" mass="32346" checksum="640EC2151ECCFC71" modified="2013-07-24" version="1">MSARRNALLFLALAAVWGSAFVAITAGLEYFPPVLFAALRYDVAGIIMLAYAYATTDQPLPRGRDQWAVVAVGAALLIAAYHALLFVGQQHTTSATAAIVVSLSPVLTTGFARIALPQERLTVVGLFGLGLGLVGVGLIARPDPDNLLAPDAVGVPLIAGAAAAFALGSVLTQRADTELPTITMEAWAMLGGALLMHAVSLAMPGESLAGVTLTAEALLAIGYLSVVASAAGFLLYFALLDRLGPIEVNLVSYVAPIVAAVVGWLLLGETVDAVTVAGFCTIAAGFALVKRRALAEEVVALRSLLRGEKREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZK7</accession>
    <name>R4VZK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446575.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08680"/>
    <dbReference type="EnsemblBacteria" id="AGN01681">
        <property type="protein sequence ID" value="AGN01681"/>
        <property type="gene ID" value="L593_08680"/>
    </dbReference>
    <dbReference type="GeneID" id="16182510"/>
    <dbReference type="KEGG" id="sali:L593_08680"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1779"/>
    <dbReference type="eggNOG" id="arCOG00214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_1_2"/>
    <dbReference type="OrthoDB" id="108340at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="231" mass="24328" checksum="B05E29BF3B02EDA7" modified="2013-07-24" version="1">MVDFQSRDTRRSLGGDESEDRDDADDPDETTGEDPSSDGSSETGDDDPAEDEHDHGSEHADHDHHADDLETVSAAVLTVSTSRSIDDDASGDAIVEVLEGEGHEIATRELVNDDYDGVQSAVSALVNRKDVDAVVTTGGTGVAPADVTPEAVRPLFEKELPGFGELFRAKSREEIGTRVVGTRALAGIADGVPVFCLPGSESAARTGTAEVVEPEVGHLAGLSRPHDIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZP5</accession>
    <name>R4VZP5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13905"/>
    <dbReference type="EnsemblBacteria" id="AGN02720">
        <property type="protein sequence ID" value="AGN02720"/>
        <property type="gene ID" value="L593_13905"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13905"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2845"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120795_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="20521" checksum="D0A40E6E328000AE" modified="2013-07-24" version="1">MSGGEDSGTSADRSASEPDVVLELPEAARGEFKDPFGPVYTDVDALLAEHSGPIVTVGDIVTYHFEQADHQPAVAFVDGRTKRETAPDDVRAELDERPNRITVGNPAGVITADLLGAIADALDTDGPTTIVVDGEEDLATVPVVLVAPLGGTVVYGQPDEGMVAVDVTEDHRAQFRDLLSTFDGDVERALQLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W009</accession>
    <name>R4W009_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_09330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446705.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01811">
        <property type="protein sequence ID" value="AGN01811"/>
        <property type="gene ID" value="L593_09330"/>
    </dbReference>
    <dbReference type="GeneID" id="16182639"/>
    <dbReference type="KEGG" id="sali:L593_09330"/>
    <dbReference type="eggNOG" id="arCOG02559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512545_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0701">S-layer</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="411"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="531" mass="53843" checksum="EEA98D33BDB07A50" modified="2013-07-24" version="1">MALTRRGALATMAAAGAASVTPASATSAGGSFRDSAVAARQSGGPAFRVEWDQVVGGEYGWHCPAIAPSGDGGVVALCNLLADAESSMATKLVEVTPSGELETIGTLGNPGYERRQYWYWDVEPGVNGGYVIAGYERQYSPYGSLTEVVPQIVHIGDGGEVQWASPVEGTPTTFQTARPTTVVAVGNRYVLASADYEGGVGTALAAYEPDGSRRWNRGYDTSLESGAKPVQLRRTADGVVLLAVRGFDDGQPTEPVLARLADDGTVADRVIPVVESDRMPHGFAVRDGRYLVVGAAPGDGGDSGWAMELPGFAATADWQGSNDAFGAGLTGAAGTVAGGGWVFAGQTGDGYGQVVGASDLSAPSLARTFDTASTYADVVPAGDGSAYVAGSTGSGAESQLVVTRVSTALDPDAVSTSVAPTTVAPGEAASLSIDVEGYDADLLSANWTVDGSPVASGFSGQTSFEETGEYTLVATITTEDDRSVSVEQTVTVGEDDGSSDGDGGGGMPGFGVVIGLLGLAGAAGLRSRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W094</accession>
    <name>R4W094_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanyl-tRNA synthetase, class IIc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_09805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446800.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09805"/>
    <dbReference type="EnsemblBacteria" id="AGN01906">
        <property type="protein sequence ID" value="AGN01906"/>
        <property type="gene ID" value="L593_09805"/>
    </dbReference>
    <dbReference type="GeneID" id="16182814"/>
    <dbReference type="KEGG" id="sali:L593_09805"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2018"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OrthoDB" id="60779at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="28072" checksum="334C72E6ECCB79E9" modified="2013-07-24" version="1">MTETPYLEDSYQRTIEATVERALDDRVVLDRTICYPEGGGQPADHGTLTVIDGADVADGAEWAITDVQKQDTIYHHLDPAADAPADPAPTPSEGATVEIDLDWERRLGHMRHHTAQHLLSRVLIDEFDAGTEGNQVYADGARIDCEQDRFTEADLALIETRVNELIEDERPVEWYELDREVAEERLDPERTRIELLPDSITELRIVEIEDFDRTACAGTHVANTGECGTFELTGRESKGGGVERLRFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0B8</accession>
    <name>R4W0B8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="10">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaB</name>
        <name evidence="11" type="ORF">L593_15130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cell membrane</location>
            <topology evidence="3 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447854.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15130"/>
    <dbReference type="EnsemblBacteria" id="AGN02960">
        <property type="protein sequence ID" value="AGN02960"/>
        <property type="gene ID" value="L593_15130"/>
    </dbReference>
    <dbReference type="GeneID" id="16181759"/>
    <dbReference type="KEGG" id="sali:L593_15130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3090"/>
    <dbReference type="eggNOG" id="arCOG03103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030009_1_1_2"/>
    <dbReference type="OrthoDB" id="97092at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="470" mass="48320" checksum="06F7D559B71EF946" modified="2013-07-24" version="1">MTAETTPEDDSFATLLAVTAIGAYLLVILGATNAVSEAATTCSTWPVCDGALGALEEPEVAIALGHRTAALLVGGLVLAATALALRRPTSRRVRASLLLALGLYPVQVGLGAVAATSGGAAGFLGVLHLGFGLAIFGGILAALAWSLDAQTASAADREPLEAPEPVTADADAQPRDIPASGLGRAKLVALAYFRMTKPRLMWLLCLVAAAGMALAAGAGVSPRVFALTMLGGVLAIGASGTFNNVLERDVDRRMNRTSDRPLAVDLVPVRNAILFGLMLAAGSLAAFLAINRLAAILGLTAIAYYSVIYTVVLKPNTVQNTVIGGGAGALPALIGWAAVTNEIGLPALALAGVIFLWTPAHFYNLALAYKEDYARGGFPMLPVVRGEATARRHVIWYLGATLAAAAVLSTVSSLGPLFALTSVLAGGAFLWAAIRLHREQTESAALRSFHASNAYLGLVLLAIIVDTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0C5</accession>
    <name>R4W0C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446835.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01941">
        <property type="protein sequence ID" value="AGN01941"/>
        <property type="gene ID" value="L593_09980"/>
    </dbReference>
    <dbReference type="GeneID" id="16180957"/>
    <dbReference type="KEGG" id="sali:L593_09980"/>
    <dbReference type="eggNOG" id="arCOG02413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181226_1_0_2"/>
    <dbReference type="OrthoDB" id="113414at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="7776" checksum="E0BEBDB3DCB51F37" modified="2013-07-24" version="1">MSSQRTIALVEEDDGWTAIDEETGLECRGEERETALERLDDAVAISFDGEPDGENDAEPAADEALEWFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W122</accession>
    <name>R4W122_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02246">
        <property type="protein sequence ID" value="AGN02246"/>
        <property type="gene ID" value="L593_11515"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11515"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="598" mass="65430" checksum="C9C043579679689B" modified="2013-07-24" version="1">MTEGFLAIDDQWRVVECNGHAAALLGSERVDLLGAELWSVAPDVVETTFADHWQRAMAERESIAFESFWPHTETSYRVRVYPTDDGGIEVYLRDVDARLPDRDGPRHATVVEAVTDGVVAFDAEDRVALVNDAITGLLDASRTTLLGTSLDALSTATKLTDADVQALRSGIEHVRTSDVDDHSLQLSLPDTEGRPGVVEVRLSPLPGNDDRVAAVIRDVTERRDHERIVRSLHAATRELFRAEDTIGACAAAVHTGADLLDLQISGIWLLDEERNRLEPVAATAGAHDVVGGLPVFGDGEGHAWTAYQRDEVMSFDDVTTTADLYNPDTPIRSELIVPIGNHGLLMAGDTEIGQFDDTDVELAEILAANTEAVLDRLQREQLLEERATELERQNERLASLEGVLSGPISATLDEVEETFDSGTIEEARDAVDRGRRLVDVAGTYASRPDATSARTGLTLGETLETAVHETERQSPTVVVSHDGTLRADHDHLLELFRALVRNATERDASAISLGVLQATSSRVRRLSGFYVEDDGDVIPRRVRDPPFDPYAGDVTVGLELELARLLARDHGWELTADPTQHGMRFEITDVTTLSPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W188</accession>
    <name>R4W188_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447230.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11965"/>
    <dbReference type="EnsemblBacteria" id="AGN02336">
        <property type="protein sequence ID" value="AGN02336"/>
        <property type="gene ID" value="L593_11965"/>
    </dbReference>
    <dbReference type="GeneID" id="16180997"/>
    <dbReference type="KEGG" id="sali:L593_11965"/>
    <dbReference type="eggNOG" id="arCOG04698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086563_0_0_2"/>
    <dbReference type="OrthoDB" id="109902at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="204" mass="21823" checksum="FC641E90903D2C4D" modified="2013-07-24" version="1">MAPDGDPTDEEGKVLSPQELELADKDGVEQLGEGRFVVSPDGTDPNVPTELSVDDADVEASAREESVAATTGEAPTASPESPSLDRTAIQDWHERQLRESPSAYGYHLSLKAGTAIDHHTLHSDDVTMAFNNLLLWYARTVDADLPPGAVLGILLSDASVPVQYPVKTLEQFVMNQGLSTDDSIGDLLEAARDDGGVVFPPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1B1</accession>
    <name>R4W1B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12140"/>
    <dbReference type="EnsemblBacteria" id="AGN02371">
        <property type="protein sequence ID" value="AGN02371"/>
        <property type="gene ID" value="L593_12140"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12140"/>
    <dbReference type="eggNOG" id="arCOG02438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2447796_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="89" mass="9523" checksum="AC1F6EDBE97C8726" modified="2013-07-24" version="1">MLVGLQYATVGGEVPENGLPTWIQFVGILNPANAFTLAARGLVPEYAAITTLPESDAALLQHWVGLLVLLAWIVIPLAVGTARFRRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1G7</accession>
    <name>R4W1G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447345.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12560"/>
    <dbReference type="EnsemblBacteria" id="AGN02451">
        <property type="protein sequence ID" value="AGN02451"/>
        <property type="gene ID" value="L593_12560"/>
    </dbReference>
    <dbReference type="GeneID" id="16180041"/>
    <dbReference type="KEGG" id="sali:L593_12560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2578"/>
    <dbReference type="eggNOG" id="arCOG00435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_2"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="57"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="326" mass="35391" checksum="CF9E297A8EA54BED" modified="2013-07-24" version="1">MTDTNTSRVDDASLEGSVEPLPIDAAGTVADDVVANVEQVMVGQRATIEHVFGAMLAGGHVLIEDVPGVGKTMLVRALARSVDSTFGRIQFTPDLLPSDVTGVSVYNQKTREFEFQPGPVFANLVLGDEINRAPPKTQSALLEAMEEEQVTVDGETRSLPSPFTVIATQNAVEPNRTYELPMAELDRFMKKLSVGYPDADQENEMVDRVLGTHPIDSLSPVTDVETLQRLGRTVAEVTVREPVRTYATELARFTRENAALGVSPRGTITLLQAAQARAVLDGREFVVPDDVKAEARPVLTHRIRTGVDAESSDDLLDRALETITPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1N5</accession>
    <name>R4W1N5_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Propionyl-CoA carboxylase complex B chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_13010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447435.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13010"/>
    <dbReference type="EnsemblBacteria" id="AGN02541">
        <property type="protein sequence ID" value="AGN02541"/>
        <property type="gene ID" value="L593_13010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180327"/>
    <dbReference type="KEGG" id="sali:L593_13010"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2667"/>
    <dbReference type="eggNOG" id="arCOG02705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="4">
        <location>
            <begin position="353"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="600" mass="65215" checksum="1B15B9A94ECB359E" modified="2013-07-24" version="1">MKLRIEATASDEEASAIAAALAEHLGESVEVVAGDGDEPIASADPPADASAAGDADESAAEAEAAAEDLGPTEREEHLRELLEDQYEGGPEKYRDRLDEQGKLFVRDRLKLWFGEDDEGSADIAFEDGTFANFDSWHPDSPDVDEYDPDSRLPADGLLTGAAEFEGRDVHFMANDFTVKAGSMAERGVEKFLRMQQRALKSGQPVLYLMDSSGGRIDQQTGFFANREGIGKYYYNHSMLSGRVPQICVLYGPCFAGAAYTPVFADFTIMVEGMSSMAIASPRMVEMVTGEEITADELGGPEVHTQESGSADLIARDEEHARELVAQLLSYLPDSAEDSPPQQETVAPVASPEGIDSVIPQHPDRGYDMTDLVDRVVDGDSWFELRPNYGGEILTGFARIDGRPVGIVANQPAKRAGAIFPDAAEKAAEFIWTADAYDVPILYLCDTPGFMAGSSVEKEGILEKGKKFIYATSSATVPQQTVVVRKAYGAGIYAMGGPAYDPESVLALPSGEIGIMGPEAAINAVYARKLAEIEDEEERAERADELREEYRRDIDAMRMASEVVIDEVIPPSELRTELAARFAFYEDVETELPDKKHGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1P5</accession>
    <name>R4W1P5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator containing an HTH domain fused to a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447450.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13085"/>
    <dbReference type="EnsemblBacteria" id="AGN02556">
        <property type="protein sequence ID" value="AGN02556"/>
        <property type="gene ID" value="L593_13085"/>
    </dbReference>
    <dbReference type="GeneID" id="16180391"/>
    <dbReference type="KEGG" id="sali:L593_13085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2682"/>
    <dbReference type="eggNOG" id="arCOG04479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_2"/>
    <dbReference type="OrthoDB" id="107730at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="98" mass="10784" checksum="D353CEC5A5972EA8" modified="2013-07-24" version="1">MTDAERTTRERIAERLREGPATASDLAEHFTIPTDVAIDHVRHVAATLDGTDEQVVVAPPECRDCGFDGFDDPANRPSRCPECKSESLEEPTFAIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1T9</accession>
    <name>R4W1T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447520.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13435"/>
    <dbReference type="EnsemblBacteria" id="AGN02626">
        <property type="protein sequence ID" value="AGN02626"/>
        <property type="gene ID" value="L593_13435"/>
    </dbReference>
    <dbReference type="GeneID" id="16180614"/>
    <dbReference type="KEGG" id="sali:L593_13435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2748"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OrthoDB" id="119206at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9284" checksum="995B93120ECB940C" modified="2013-07-24" version="1">MSGRPLDVLEAAVGDDVEVRLKSGETYRGTLAGYDQHMNLVLDDVVASASSEEAEPSDDSNAESDDGSSVDVRDTTIIRGDNVVSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1V3</accession>
    <name>R4W1V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447535.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02641">
        <property type="protein sequence ID" value="AGN02641"/>
        <property type="gene ID" value="L593_13510"/>
    </dbReference>
    <dbReference type="GeneID" id="16181977"/>
    <dbReference type="KEGG" id="sali:L593_13510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2765"/>
    <dbReference type="eggNOG" id="arCOG04626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078972_0_0_2"/>
    <dbReference type="OrthoDB" id="89564at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043859">
        <property type="entry name" value="DUF5821"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19138">
        <property type="entry name" value="DUF5821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="29295" checksum="16F243C98A9EA534" modified="2013-07-24" version="1">MESNLLGDRLDDILRTALSEAGEELVVVNPTGDGLESLIDVASERDDLPHIRVLAEERTLKDVMDDFIVASNAAVLIEDDVLDFRTVEDGPENALLVTEDRVVAIVDAGTQVAGLVSDEADFVGAANDRFESDWDGADEYSLRTPSIERVRKTLADDISPDAEEDFTNILASLETARGDGDGLDEVTISLLVAAKNEALLYDISKWGEDIGIASKATFSRTKTKLEDKGLLDTEKVPIDVGRPRLRLKLGDERLQAADNGEIASAAQSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W352</accession>
    <name>R4W352_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase H subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445211.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01830"/>
    <dbReference type="EnsemblBacteria" id="AGN00317">
        <property type="protein sequence ID" value="AGN00317"/>
        <property type="gene ID" value="L593_01830"/>
    </dbReference>
    <dbReference type="GeneID" id="16179964"/>
    <dbReference type="KEGG" id="sali:L593_01830"/>
    <dbReference type="eggNOG" id="arCOG03363">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149095_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014275">
        <property type="entry name" value="ATPase_A1A0-cplx_hsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02926">
        <property type="entry name" value="AhaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="110" mass="12829" checksum="06031665E37433CF" modified="2013-07-24" version="1">MPRPEVLERVKEAEREADDIVAEAEADREERLAEARERAEEIREEAETEARDLRERRLEAAREEIEQEREQILEDGRANREELVADAEEHLDDVVDDVLELVETAVHAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3C5</accession>
    <name>R4W3C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445341.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02480"/>
    <dbReference type="EnsemblBacteria" id="AGN00447">
        <property type="protein sequence ID" value="AGN00447"/>
        <property type="gene ID" value="L593_02480"/>
    </dbReference>
    <dbReference type="GeneID" id="16182744"/>
    <dbReference type="KEGG" id="sali:L593_02480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.503"/>
    <dbReference type="eggNOG" id="arCOG00777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_7_1_2"/>
    <dbReference type="OrthoDB" id="90643at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="13632" checksum="356C1933B32059D2" modified="2013-07-24" version="1">MDVDTFFEEMPFADLLGVEVTEVADGHAEGRIEMRPELSWSDETVMAHGGVTFTLADTIGGAALVSLVDQPVPTIDMRIDYLEAGTGDLRAEAEVVRCGDDVGVVDVDVYAVEGDAHVADARGVYKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3L1</accession>
    <name>R4W3L1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">engB</name>
        <name evidence="9" type="ORF">L593_03230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445491.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03230"/>
    <dbReference type="EnsemblBacteria" id="AGN00597">
        <property type="protein sequence ID" value="AGN00597"/>
        <property type="gene ID" value="L593_03230"/>
    </dbReference>
    <dbReference type="GeneID" id="16182519"/>
    <dbReference type="KEGG" id="sali:L593_03230"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.653"/>
    <dbReference type="eggNOG" id="arCOG00355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_2"/>
    <dbReference type="OrthoDB" id="73254at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="206" mass="23209" checksum="C2AB7A1F4C3A70A2" modified="2013-07-24" version="1">MIEERPDRSTEVVLLGRSNVGKSTLMRELTGHSFDTGRRPGVTQAANHYDWTGPDFVLTDLPGFGFMEGVEADRREEIKTAIVRYLEEYADQILVGILVLDANSAVEIIDRHADRGEVPHDVELFGFLQELGIPTVVAVNKMDKADDRDETLDAIAERLGLHPPWQQWQDTIAPITAKRGSIEPMTEAVGEHLRDQKREDLLQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4I2</accession>
    <name>R4W4I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446036.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05965"/>
    <dbReference type="EnsemblBacteria" id="AGN01142">
        <property type="protein sequence ID" value="AGN01142"/>
        <property type="gene ID" value="L593_05965"/>
    </dbReference>
    <dbReference type="GeneID" id="16181659"/>
    <dbReference type="KEGG" id="sali:L593_05965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1222"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590016_0_0_2"/>
    <dbReference type="OrthoDB" id="29933at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="453" mass="50092" checksum="455047389F08A849" modified="2013-07-24" version="1">MDRYDVAIVGGGPAGAAAAYEAASRGAEAVVLEKGVPRADRDGLGPDSTDAAGMLDYWIEIMGIDPDELPDDVILQELSGTEFEGPTESLRLERTGMEADYPHFGYTFQRARMDDWLIERAEDAGAEYRVEASVTGVDSDLTGDPEHTVSLRNGEEIQADRLVLSDGPQRQVTNRVLDPLLPDGQDITDYVGTTKANHIAYQEHREFPEDAIEKDMLRFWWGAMPGETAYPWVFPNDGTVARVGLTMPIGLDIDDFPNQEEYLLLDADDDSIPSGSEYIERLLERAYPEYDLEDFPLVEDRGKRDGTETYAISSTRPIDSPTGAGIAIAGGAMGTTSAFHEGGYHVAVRSGAIAGELAATRRLEAYNEAWKEAIGDEILRNVSFADIVADYEPADWDRAFSTARKLMQREGSLIGFSPRAGFSGLKLFAQYWWTKRKFRDGGYVQLHEDEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4K2</accession>
    <name>R4W4K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redox sensing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01182">
        <property type="protein sequence ID" value="AGN01182"/>
        <property type="gene ID" value="L593_06165"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06165"/>
    <dbReference type="eggNOG" id="arCOG02364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728822_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="35352" checksum="3491D0B254C36D14" modified="2013-07-24" version="1">MAVAIGHLLTEGEGLGTGLEGLILFTLSTTVLYTGYELPDRSLSRAGAVDALRNTAVFVVAFVLLANAIVLIWHYEQGHVEDAQFVVIFAGVLGAAVGGQANVYAVEFREAFDRNQALTKLLTVNQRVLRHNLRNEVTIVLGHLEDGSDGAGASAEDVRIAREHLEHLLETSREAQQISDVWEQDATEEFDLPRFLAERVEAFETEYPDATPTIECTDPPLAVAHVALPLAVDELLENAAVHNGADVEITVSCREVAGGVAIEVADDGEGIPAVETDVLFNPAETTLEHGTGLGLWLVYWIAMQSDGELRFASNQPSGTIASIVMPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4P8</accession>
    <name>R4W4P8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-fructose oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446146.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06525"/>
    <dbReference type="EnsemblBacteria" id="AGN01252">
        <property type="protein sequence ID" value="AGN01252"/>
        <property type="gene ID" value="L593_06525"/>
    </dbReference>
    <dbReference type="GeneID" id="16181783"/>
    <dbReference type="KEGG" id="sali:L593_06525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1331"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="42530" checksum="5B1CBB31A7184C9A" modified="2013-07-24" version="1">MTWTVAGINFAHFHMGDQLGNVVDNPDTELVAICDEDPERATLSLETTAEQFDLDDEQVYRDHERCLEENDVDLVVTCPVPTEHADWVEHLAEYDVHVQLEKPFATSVEDCERAMAAMEDSAGELAINWPLAWYPTHRTTKRLVEEGRIGEVIEVHYYDGNRGGQRFTEVEYGDEGEMHFMGDLEGGGPIENVEPRQRDEQAWWHDPDSGGGSLHDYLGYGTTFGTWFRGGDLPISVTANTFVPDHMDVDTHCIAVAKYEEGLSKFESRWGTFTDPWIDQPQPKCGFVLVGTEGTISCYDYEETVRVQDEDHPEGYEVEVDDLAPPKQGPIQYMVDRMETEEPVEFGPLRPDLCRDAQRIADAAVESAERGEEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4Z7</accession>
    <name>R4W4Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_07410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446321.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07410"/>
    <dbReference type="EnsemblBacteria" id="AGN01427">
        <property type="protein sequence ID" value="AGN01427"/>
        <property type="gene ID" value="L593_07410"/>
    </dbReference>
    <dbReference type="GeneID" id="16182110"/>
    <dbReference type="KEGG" id="sali:L593_07410"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_0_2"/>
    <dbReference type="OrthoDB" id="79655at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="369" mass="39222" checksum="8C3DE01DC609DD1B" modified="2013-07-24" version="1">MNREQAFLLVLLVATAVASFYVLLPFLNYVLGALLLGYVLRPLHTRLAPHVGERPAAITVIATAAVAIIAPLVYIGYVVYQDAQDLAAGESSLNFQAIETELESTTGESVDLASVTGDFGTLLGDFLYGNGVEIFSYVTTVLLGFTLVLFLVYYVLLDGPDFVQWTVSTAPLDDAVAHEIASRMDRMAWGVVAGHIFVAFVQGIVGGVGLFVAGVPSPIFWSAVMVITALLPVVGAFLVWGPAAGYLYLVGEPRMAAFLFLWGLVVVSLVDNYLRSIAIDQSADVNPGVILVGVIGGIYSLGAVGLFVGPLVVGLFAAMIRAFDAHYDALGRDTPPPEPPQDGRLSWLETQPAATREDYGGHANPDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5C4</accession>
    <name>R4W5C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein transmembrane region/thiol-disulfide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446536.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08485"/>
    <dbReference type="EnsemblBacteria" id="AGN01642">
        <property type="protein sequence ID" value="AGN01642"/>
        <property type="gene ID" value="L593_08485"/>
    </dbReference>
    <dbReference type="GeneID" id="16182431"/>
    <dbReference type="KEGG" id="sali:L593_08485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1738"/>
    <dbReference type="eggNOG" id="arCOG04522">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="218" mass="21646" checksum="5F4E031DB44ABF8E" modified="2013-07-24" version="1">MAETVVGALAFAATAGVATFFAPCAFPLLPGYVGYYVHENDQETSMVLPAGAAAGGALAALAVVAAVVLIVGQPVKAALPTLEPVIGIGLVALGVAILLGRSPELRIALPERPSSVVGFGVFGAAYAVAAAGCVVPLFVGVLTQALGFGIGPAALVLGVYALAVAAPLVGVTLLAGAGVDEWQRLGRHSGAIQTVAAVTMVLAGVWQLYVAIFRFGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5M0</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="274" mass="29390" checksum="A71F4C57E98A945E" modified="2013-07-24" version="1">MHVAITGAAGQIGEIAREAFEPAERTLFTHSEHEGLDATVLEVTDREAVGAALADAGADVLLHLAWGPAGRDDWEDGHASNLEGTIDVLEAAVEHDLDRVVLASSIHAVGMYNRERADEMESLVAEPATVIGPDDPPRPDSYYGVAKVACEAMGRYYADRYDLEVVPLRIGWVCDREELRAVATAASSESDRARGRFARATWLSPRDCRAVCEAAVRADLGPAMTPGRPLPAISANADRFQTLAPTMRAIGYRPRDDAAAVLDKAERGGTAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V4</accession>
    <name>R4W5V4_9EURY</name>
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        <submittedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
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    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG06405">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
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        <property type="entry name" value="VKG_COase"/>
    </dbReference>
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        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="510" mass="56673" checksum="7FBB1D5B57FCBEEE" modified="2013-07-24" version="1">MTSNASTDHVTRRATRILDWFGAAVQRRVQIDLRALAVFRIAIGSIIVFDLLLRARNFTAFYTNDGVLPNEALYRSYTEVHSLHAWVGETWLVALLFVGAALLGVSMILGYRTRTVTFLSWVLLFSLHNRNPMVLNGGDTMLRLLVFWSIFLPMGERWSLDARRLERDRATVASIASLAILAQIVIMYVSNFVHKTRGQAWIDGEAVPYILTLDQFTVFLGPHLAQFPDLLVGFSYGWMVLMALAPFLLLLTGWPRAVVATGFVGMHTGMFLTLQIGVFPIVVVSALLLFYPPVVWDRVLEAAAERGITDRIRDVRSTISDAVPSKPVGPIVPLPATLPGLRPVLSTVVPAVFLVLIVVSNAHALGYAAAPPDPGQELLDKTDTEQNWRLFAPHPLSNTRWFVAEGTLASGETVDAVHGGNVTRDRPPNPADTVGTARWRKYLSNLYGNDDHQSYYANYLCDRWNRTHDGRLESVEIYAFSQEGTPWGGESDVDRTRLVAYDCSGPLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5X8</accession>
    <name>R4W5X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterio-opsin activator HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">L593_00465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444942.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00465"/>
    <dbReference type="EnsemblBacteria" id="AGN00048">
        <property type="protein sequence ID" value="AGN00048"/>
        <property type="gene ID" value="L593_00465"/>
    </dbReference>
    <dbReference type="GeneID" id="16181823"/>
    <dbReference type="KEGG" id="sali:L593_00465"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.95"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101251_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="220" mass="24392" checksum="908189244A9A2F3B" modified="2013-07-24" version="1">MTHAELTVTLPDGTWVKDVSAANPDATFRVLAALPGTETGFGLVELVADDPRPVLTAMEDHDAITRIELLQAGEDRAMVQFETTQPLLLFSARESRMPIELPIDIVDGTTTLELTASRDRLSELAHQFDAFGLDYAVEYVSPRVESERLLTDRQRELVTTAIEMGYYDTPREASMTELAEALDIAKSTCSETLHRAEEKVIKRFSEGTLHDTDPATVEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Y9</accession>
    <name>R4W5Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446911.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10360"/>
    <dbReference type="EnsemblBacteria" id="AGN02017">
        <property type="protein sequence ID" value="AGN02017"/>
        <property type="gene ID" value="L593_10360"/>
    </dbReference>
    <dbReference type="GeneID" id="16182209"/>
    <dbReference type="KEGG" id="sali:L593_10360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2136"/>
    <dbReference type="eggNOG" id="arCOG04232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OrthoDB" id="8357at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="2">
        <location>
            <begin position="38"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="567" mass="63323" checksum="FAE4A2A12A353598" modified="2013-07-24" version="1">MFDDEELRSLRESREAWESNTLQPVLDRHGERKDRFATVSNLEVDRLYDPTDLEDLDYEDDLGFPGEPPYTRGPYPTMHRGRTWTMRQFAGFGTAEETNERFHYLIDEGQTGLSTAFDMPSLMGIDSDDPMALGEVGKEGVAVDSLRDMEVLFDGIDLGEVSTSFTINPSAPVIYAMYVALADVQGVPREQVRGTLQNDMFKEFIAQKEWVVPPEPSLKLVTDVIEFATEETPKFHPVSISGYHIREAGSTAVEELAFTLADGFAYVEDAMERGLDVDEFAPRLSFFFNCHNSLLEEVAKFRAARRIWAEKMDEWYDADAADSRRLKFHTQTAGQSLTAQQPLNNVVRVTIQALASVMGGTQSLHTNSFDEALALPSEKAVRVALRTQQIIAEESGVADTIDPLGGSFAVEALTDQVESEAMAYMETIRERGNGSMREGVLDGIEDGYFQREIQDSAYEYQERVEDGEEVVVGVNKYTIAEETAADTLHVDEEQARETQLDRIESVKDERDEQAVEDALAAVRDAAENDENTIPAIVDAVKEYATMGEIMQVFEDVYGEYAGEVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5Z1</accession>
    <name>R4W5Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_00565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444962.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00565"/>
    <dbReference type="EnsemblBacteria" id="AGN00068">
        <property type="protein sequence ID" value="AGN00068"/>
        <property type="gene ID" value="L593_00565"/>
    </dbReference>
    <dbReference type="GeneID" id="16182456"/>
    <dbReference type="KEGG" id="sali:L593_00565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.115"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OrthoDB" id="65016at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="111"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="357" mass="39838" checksum="04527EF9B712D239" modified="2013-07-24" version="1">MDTEELSEVLQAADLSFYQADAYVTLLELGTASATEVARSSDVPDARIYDVLRDLDELGYVELYEQDTFQARATDPQTVVENLTERASLFEDAAAEIEDRYEQPSLDDHTVSIVKRFDTVLEAARTFVAEAETQVHATLTPEQFAELRGDLEEAKERGATVNVTLLYRDEDPELGDSDFEGVCSAVHRRPRPSPFVVTSDLQRTAFASNPAAIEDYGMILQNRSFTYVFFWHFLIFMWLPWPVLYAEEPGETPKRYADVRQFLLEYLQPIREGATVTVEIEGRDTESGESLTIDGSVVDTEYVSEAASALDSELLELAGTATIVVDDGEERHTVGGWGARFEDVEAKRITVTGVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W631</accession>
    <name>R4W631_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446976.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10685"/>
    <dbReference type="EnsemblBacteria" id="AGN02082">
        <property type="protein sequence ID" value="AGN02082"/>
        <property type="gene ID" value="L593_10685"/>
    </dbReference>
    <dbReference type="GeneID" id="16181405"/>
    <dbReference type="KEGG" id="sali:L593_10685"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2203"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023282_0_0_2"/>
    <dbReference type="OrthoDB" id="13246at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="253"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="69020" checksum="6AD271913FC45B91" modified="2013-07-24" version="1">MALDDFTEYDPDEDDASGDAVEDESARDADEEATDVHTASEASADDAAGLTYETADAEAPERVDGLGILSTSRGLRIDETGEETELQAYVTAPNRSDVRVGSYVLVPYPERGDPGASGERLFCRVAGLEYAQEFQSDDATELRARRAMREGAIDETDYKFLADLDPVAIIYEDGIDEETGDPEQKRRATDRVPKPETTVHRARDADEIKTGLKIPGDGIFLGHLAVGGERVTTAAAPPTIDYRLNDDYTAGDPLLFRHTLIAGGTGSGKTHAAKNVLRQVLDDERTYPMGDGREVQAAVVQFDPQDEYAQLHDDNPDLDADTARQYEREGIANGGHDDTLAFVPKVGSATYDGGGHRAEQVEFTVPFSMVRGNPWLVAGSGLNDNQYQALHELLDRFFGQYGSDGTYDQFTEFMDDPALREELDETGRVHEATFDAVFRRVRGFGHVFDQDARPITDQVRDLVRPGGLSVVPTYHISDSRAAEVVVLAVATLLVDEKLSSDPTYDRIKDTPLIVGMDEAHNYLTDADSVQARRVIGTFTDAAKQGRKERLGLFLVTQDPQDIHDAVFKQINSTVVLNLGDEDAISAVNIPTALEQKVPYMEQGQMVVYSPDNSEPVELVGLEHCLVKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W647</accession>
    <name>R4W647_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Medium-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01015"/>
    <dbReference type="EnsemblBacteria" id="AGN00158">
        <property type="protein sequence ID" value="AGN00158"/>
        <property type="gene ID" value="L593_01015"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01015"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.208"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="414"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="518" mass="57581" checksum="984F61750CA9B606" modified="2013-07-24" version="1">MHRYTFAEYAERCRKLASALEQAGVERGDRVATFAWNNHWHQECYYGVSCMGAQVHMINLLLPDAHIQHIVDDAQDRILVVDPVMLERLEEAYDEDAFASVEQYVVMGDQVPETSLEPVVDYESFIADGDPNYEFPELPEDQPAGMCYTSGTTGKPKGVEYTQKMYWTQVMAIMTGEVGIRSDDVELTYVPMFHVSGWSRPFATIAAGAKTVLPGPAPEPEDLAQMIEAEDVTLSAAVPTVFMDLLEYARDTDVDFSTIRYFLSGGSATPKSLIRDWRETHDVDLVSGYGMTETTPVTHAYAPKPGTDPSGEELDELRSLSAGIALPGVEFKVIDEDGEEVPWDGESLGELWMRGPWVSTEYFNAPEATAESVTEDGYLKTGDIVRVTEEGYVDVVDRLDDLVKSGGEWIASVEVENRIMGLDDVVEAAVVPVPHERWDERPAAFVVSREGADEAALREDVRAIVAEEYPRWWAPDAVRFIDEIPKGSTGKFSKRTLRDEYVDEELAEQVAANAPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W682</accession>
    <name>R4W682_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rps3p</name>
        <name evidence="6" type="synonym">rps3</name>
        <name evidence="11" type="ORF">L593_11135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447066.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11135"/>
    <dbReference type="EnsemblBacteria" id="AGN02172">
        <property type="protein sequence ID" value="AGN02172"/>
        <property type="gene ID" value="L593_11135"/>
    </dbReference>
    <dbReference type="GeneID" id="16181548"/>
    <dbReference type="KEGG" id="sali:L593_11135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2297"/>
    <dbReference type="eggNOG" id="arCOG04097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_1_0_2"/>
    <dbReference type="OrthoDB" id="60366at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="35774" checksum="4B379CC035A3AE78" modified="2013-07-24" version="1">MADEHQFIEDGLQRSQIDEFFADELGRAGYGGMDVAKTPMGTQIVLKAEKPGMVIGKGGENIRSITTTLEEEFDLEDPQIDVQEVDEPDLNARIVADRLANALERGWYFRKAGHTTLERIMDAGALGAEIVLSGKVTGARGRVEKFSDGYIKHNGEPAEEVVDHGQGVAVMKLGTIGVTVKIIPPGAELPDDFEIAEGASTESLEPEEAEAGVEELLEEPDDEDLEELEDAAADADEATGEADLPEEVVEGEEFEDPEIPDDDDVAEELEELEESVEEDLDEETEAAAEELVEEMEEADEAESDDEDTEADDEAEKADADDADEEGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H6</accession>
    <name>R4W6H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445287.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02210"/>
    <dbReference type="EnsemblBacteria" id="AGN00393">
        <property type="protein sequence ID" value="AGN00393"/>
        <property type="gene ID" value="L593_02210"/>
    </dbReference>
    <dbReference type="GeneID" id="16180118"/>
    <dbReference type="KEGG" id="sali:L593_02210"/>
    <dbReference type="eggNOG" id="arCOG06289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103607_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12485" checksum="A9D6CFCF434F4599" modified="2013-07-24" version="1">MFGEEPEAEREAVPDEPFRDDEEPEDPGAIEAEPEFDVRTGEDLVDDLPSGAEVPADVRKVFWSSVLLLKVALVSLTLAALLAYFRGQLLLAAGLAVLGLLAGTRTVLKVRSYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I6</accession>
    <name>R4W6I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_02310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445307.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02310"/>
    <dbReference type="EnsemblBacteria" id="AGN00413">
        <property type="protein sequence ID" value="AGN00413"/>
        <property type="gene ID" value="L593_02310"/>
    </dbReference>
    <dbReference type="GeneID" id="16180167"/>
    <dbReference type="KEGG" id="sali:L593_02310"/>
    <dbReference type="eggNOG" id="arCOG01570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982141_0_0_2"/>
    <dbReference type="OrthoDB" id="106422at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN00413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="265" mass="28654" checksum="B2049E1A160590B7" modified="2013-07-24" version="1">MAPTVQLPETEQIPEWLLDWPIVLVSLIVLVGVLAGFLLGRVSRSVLEAAGIPESVEGTAFERTAQSLGTSTVSIVSRLLSWFVYGVTLLAAIFAFQPTDTNWLWQRIVAFIPQVFIALLVVVLGFVVADKAELLVSERLRGVKLPEVSVLPKIVKYSVLYVAFLVALGQIGVATGALLVLLGIYVLGVVLLGAVATKDILSAGAAGIYLLLREPYGIGDRVTIGEREGVVQEVGVLVTHLEDEDAEYVVPNDKVFEHGVRRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L9</accession>
    <name>R4W6L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445362.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02585"/>
    <dbReference type="EnsemblBacteria" id="AGN00468">
        <property type="protein sequence ID" value="AGN00468"/>
        <property type="gene ID" value="L593_02585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180271"/>
    <dbReference type="KEGG" id="sali:L593_02585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.524"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_2_1_2"/>
    <dbReference type="OrthoDB" id="72347at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="27405" checksum="02C9E30AE28A61FA" modified="2013-07-24" version="1">MTDPITALQRLGLSKYEAEVFVALQQVDSATASEIDELADVPRSQVYGAAEDLEERGLVDVEHASPKRYRAVSLEEAREQLRRDFEREQEQAFDALAELEGNFAGGEERQEAIWTVRGRQKIDARVESFLDDAESSVSFGTEAALLDEPTVAALLDASERADVTILSADRSVLEAFEGTGVETVELPDEFDQNGDPRGRLVVVDDRTVLLSVVRPDGEETAFWSSETDFAEWLIRLIDTHFGSHAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P6</accession>
    <name>R4W6P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12540"/>
    <dbReference type="EnsemblBacteria" id="AGN02447">
        <property type="protein sequence ID" value="AGN02447"/>
        <property type="gene ID" value="L593_12540"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12540"/>
    <dbReference type="eggNOG" id="arCOG08115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393024_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="93" mass="9012" checksum="62F3F6634C960537" modified="2013-07-24" version="1">MSASGSTLGQIAGNLLAAALMIVLAVLTFFITVFVVDAGASLAGYDDNAFVVLSAAVLAGSAIIAGGIAPIGAVDASVSVGGFGGEEKRDPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Q8</accession>
    <name>R4W6Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447361.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12640"/>
    <dbReference type="EnsemblBacteria" id="AGN02467">
        <property type="protein sequence ID" value="AGN02467"/>
        <property type="gene ID" value="L593_12640"/>
    </dbReference>
    <dbReference type="GeneID" id="16180100"/>
    <dbReference type="KEGG" id="sali:L593_12640"/>
    <dbReference type="eggNOG" id="arCOG08163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120785_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="19574" checksum="C3D15E0E159E2679" modified="2013-07-24" version="1">MPDDDLLERFAVDAAASDEQFLAAAKLYAREVVDRHDLSVDVSDLDWSVSKRAKRRAGAVKHRDGNPESVVITRAHFTEHGWEAAAATVRHELIHVHLLAEDGDATHGAAFEALADDLDAPINCERFTDPEWWVICEDCESRIARYRRSKLVEQPERYRCRDCGGEFRVEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6R1</accession>
    <name>R4W6R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_12665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447366.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12665"/>
    <dbReference type="EnsemblBacteria" id="AGN02472">
        <property type="protein sequence ID" value="AGN02472"/>
        <property type="gene ID" value="L593_12665"/>
    </dbReference>
    <dbReference type="GeneID" id="16181907"/>
    <dbReference type="KEGG" id="sali:L593_12665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2599"/>
    <dbReference type="eggNOG" id="arCOG02680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110112_0_0_2"/>
    <dbReference type="OrthoDB" id="117224at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012041">
        <property type="entry name" value="Znf_CPxCG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42195">
        <property type="entry name" value="PTHR42195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19769">
        <property type="entry name" value="CPxCG_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015877">
        <property type="entry name" value="UCP015877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="216" mass="23709" checksum="06BEBFB7F918667C" modified="2013-07-24" version="1">MSDSIERVALVCPACSQEQETVHEVLSPGGQATVRCTECDHVHKEALPSDDTVERDVVVSQSGDSFTARTDVDPEETIAEGDEFLLETEDGIFSVRVTSVEIGQDRRVEETTAEEATTIWTRAVGNVAVNVTVHPSDGGREETYSTTVHVPGDYEFVVGDSDSFGEEEFSVEGIAIRDDATGYEYEKLDFDGDEAVAKDIKRVYARDETSDAWSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6S0</accession>
    <name>R4W6S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_12740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12740"/>
    <dbReference type="EnsemblBacteria" id="AGN02487">
        <property type="protein sequence ID" value="AGN02487"/>
        <property type="gene ID" value="L593_12740"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2614"/>
    <dbReference type="eggNOG" id="arCOG01757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="315" mass="33688" checksum="6780FE2E603FB114" modified="2013-07-24" version="1">MTDPRVLLPHQVPAEAADELSAELRAQAPDLPIAVAADESETETLLDDVEGVVTWEFGPEWIERADDLEWIHVLSAGVDHFDLDAAESAGVRVTNASGIHAEPIAEQVVCYAFLFERGILADLRRQPSRTWERHDGEEISDKTIGIVGVGAIGSRVAERLGAFGATTIGTKRDPTTGGDGVDELYGAQDLDVVLDRSDYLVIACPLTDETEGMIGEAELAALDDEAVLVNIARGEIVDEDALVDALEADELGGAALDAFAEEPLPEDSPLWTMDDVVVTPHVSGTSQFLTDRNAALVVENWAALQAGEALTNRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W794</accession>
    <name>R4W794_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
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        <name evidence="2" type="ORF">L593_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447646.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14065"/>
    <dbReference type="EnsemblBacteria" id="AGN02752">
        <property type="protein sequence ID" value="AGN02752"/>
        <property type="gene ID" value="L593_14065"/>
    </dbReference>
    <dbReference type="GeneID" id="16181053"/>
    <dbReference type="KEGG" id="sali:L593_14065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2878"/>
    <dbReference type="eggNOG" id="arCOG00150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_2"/>
    <dbReference type="OrthoDB" id="16335at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="442" mass="47398" checksum="30A7D7D32588CE33" modified="2013-07-24" version="1">MTNSTESGLGRREYMRGAAAAGAAGTTLFAGCLTGDDGGGDGVEGVPDEPAEDETFEIVHWWTAGGEEEALNALIDSYTEAYGYSGSDINNNPAPGGAGSAIDTAIQTRVIDEDPPSTFQIWPGGSLTPYTDADALNAINDVWTDEMESSYLDGVIDTAQDGDDFVAVPLNIHRLNQVFYNVEVAEDVGVDLGGLSSPEDLLDAMASADEAGYIGMAQQTGSVWSTLQLWEMVFLGQHGADTYRDVLDGNVGDYESQIQESLQLIVDYREYFTPNASSVTWDEANQDVISGDALLIHQGDWAAGQYAAAEGFDYGSGWDYATVPGTSDVYSIVMDSFVMPDPNPSPTMTKQWLRHCGSVEGQIAFNTRKGSIPPRTDVSMDEFPPFLQDQSSDFGDSSEQIPTIAHGSGTDPDSKSTFEQIFSGFLENWNASETAGQIVDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C6</accession>
    <name>R4W7C6_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447716.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02822">
        <property type="protein sequence ID" value="AGN02822"/>
        <property type="gene ID" value="L593_14415"/>
    </dbReference>
    <dbReference type="GeneID" id="16180549"/>
    <dbReference type="KEGG" id="sali:L593_14415"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2950"/>
    <dbReference type="eggNOG" id="arCOG02282">
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    </dbReference>
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    <dbReference type="OrthoDB" id="64431at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="195" mass="22156" checksum="DF5E6233D7FB4808" modified="2013-07-24" version="1">MNLREHDNRDDMKVWLSQADVAELLDRADGTHQRLAFALGSRCGLRSHEVLDVAPEHVVETDAGTVLRVWHGKGDQFRETPVPRDLATTIRTVADVRDAPASSSLLNVTSTRSLRRWLRSSAEELAENTGEAGWNHLAFHDLRRTWATSLAASDVDPLLVCDWGGWNDLETFLDHYRGTYSPEAQRREREKVDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H1</accession>
    <name>R4W7H1_9EURY</name>
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        <submittedName>
            <fullName evidence="6">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447801.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14865"/>
    <dbReference type="EnsemblBacteria" id="AGN02907">
        <property type="protein sequence ID" value="AGN02907"/>
        <property type="gene ID" value="L593_14865"/>
    </dbReference>
    <dbReference type="GeneID" id="16181644"/>
    <dbReference type="KEGG" id="sali:L593_14865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3036"/>
    <dbReference type="eggNOG" id="arCOG01771">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037598_0_0_2"/>
    <dbReference type="OrthoDB" id="33387at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="634" mass="67778" checksum="BBAEFE33CDE9D90F" modified="2013-07-24" version="1">MLPSPYAVLIVATYAVALAIAWYLGDGDRWRKRLTDRFWYGVPWGTLVSIAFVLAVYLFVQGGIEHWHDPTVIPFRAWSYLYPVGLLTAGFAHSSSGHLVGNLMGTIALAPIAEYAWGHYPGGSRSTTSDRSTDQATDRLDGTPRLRERLQTWTTIPWVRAFVCFPGAVLALGLLTALFAVGPVIGFSGVVFAFAAFALVRYPIATLVAILLSGVLSTTYYAIQYPVVYAEISGSAPSVPWWATIAVQGHALGILLGVVLGLALMHHRSVAPNVNRVFLAMLVYGMSEGLWAVYWFEGNGVYVLYRGLGVSLVVGLAVLVALAVTSSDRPVTATLARLPRSPTPSQVAIGFLALLALAVTATGGYSIVAGKSFVVLVVVGLFALVLAVPAVAVLAPVTFDAAPTGFQSTFTVLVVVLVLVAIPATIPNLVTVGDDPVPSDQSIEVDGYSITYAEDVRNQMIPAIELPAVANETAVPTSGVIVVNEERHIWTTALSKQYLASEGDGSVTVGGVGWRETVHADRIGWTVTGNDTAYAIDLSHGNESIRAYSSPEQRAQPVIENHTVGLVPARDRFELRVYQNNSTVGRSPIPAIGNDTQVGPITFSTGQSNDLVTIFAIADGTRVQIAQRETYRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7Q1</accession>
    <name>R4W7Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_05795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446002.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01108">
        <property type="protein sequence ID" value="AGN01108"/>
        <property type="gene ID" value="L593_05795"/>
    </dbReference>
    <dbReference type="GeneID" id="16181501"/>
    <dbReference type="KEGG" id="sali:L593_05795"/>
    <dbReference type="eggNOG" id="arCOG02920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="110949at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BlueCu_1"/>
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    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
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        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="6">
        <location>
            <begin position="45"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="18119" checksum="48582092C89C3002" modified="2013-07-24" version="1">MSEQDAATLDRRSLLRAGAGGTAAALGGAAATGSAAAQSQEIMAGTGDAPLAFSPDSVTVEPGTTVTWSWGTDGHNIVVDSQPDGANWEGHTTVENTGFEYQHTFEVEGTYEYYCEPHLSAGMEGTIEVAAGGGGGGGGSSGPPKVSSSALNLSLGAMGTMASVVALVFYFIKYGGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X1</accession>
    <name>R4W7X1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445033.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00920"/>
    <dbReference type="EnsemblBacteria" id="AGN00139">
        <property type="protein sequence ID" value="AGN00139"/>
        <property type="gene ID" value="L593_00920"/>
    </dbReference>
    <dbReference type="GeneID" id="16180571"/>
    <dbReference type="KEGG" id="sali:L593_00920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.189"/>
    <dbReference type="eggNOG" id="arCOG03730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021291_0_0_2"/>
    <dbReference type="OrthoDB" id="36125at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="878" mass="92032" checksum="9ED525E52889AC68" modified="2013-07-24" version="1">MERRIEADVEGWPTRPFEDGYDGLRQLASVDFSGVVRAGGAWLFFVNGKIVGVFEGAIDDVEGAQGTAHKAPHPSLPLLYAMQTEGGDTRAKYYTNDTPISEVDSTLSSGSFTGYVELSENVLSGDYYQLYHGGHSMSVAFVGNSGKMITGEEAFERADDEVGIYEVVDVDIGVMEVPQPEEPETATDESDAGSDESEGVETASKSDAGGDPSPDDTDDESAGSAADDGAAATGGDDGPSAATGDDGSAADDAHAAGSGAADAPTAAEGNPSTEIADEADATDEEDQSDGSASPTAGDDRGATGDSSDGTAAAARATNSATDSSRSPRNEATPEAGSGEQPGADAASNATTSADSTRSASAADRERGTESAAASTPETGSADRSSSDRASAPSAGTGDPASHQRGSEPAAADATDRSAAPSADAGDDASRREDAPRQSEAAWREATTVPALDPDRTEDVEVSGQSQTQTRQQRQSRSTQQGRNANASSARSQSRSSTNTRDSSTAQSASGRSGSSSTRSSGSNSRSSGSGTRPSGSSGRSAATDRTQGAENTLEQEVLEREDRIDRLQQRVTNLEDERDEVTEERDRLQERVDSLTEENESLRGEIRSLEDEIEELEDKAASAEPTPSENAGAGASGGPLTPRAALEGTDLFVRYDSKSAPTLEAAHDGSADATAVNQNLRLDVHTQFEDDGATVDGEPFEAFLQETMAYRFVEWLVRILPYEIRETDSASELRDLYDAIPEIDRVEFHGEVARDAVEGEEGAPSETFDVVVRDKMGEALLVANMNDARDPATGRMIVDLQEGASRVKEHSMALAGAFFVTRSFFEPAALETASEATSGSLLSRDSRASYVKLSRKQGYHLCLVEARGDDLHLNVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W814</accession>
    <name>R4W814_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01305"/>
    <dbReference type="EnsemblBacteria" id="AGN00214">
        <property type="protein sequence ID" value="AGN00214"/>
        <property type="gene ID" value="L593_01305"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01305"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.266"/>
    <dbReference type="eggNOG" id="arCOG02155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170070_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11172" checksum="9B0E6618CCA3FF81" modified="2013-07-24" version="1">MDTMHGGLRSDGGLEELTTLVGREVYSNNGVYVGEVEDVRLDVDAKAVTGLALGEINADLLAGQLEGGQRGAIVPYRWVRSVGDVIIVSDVVERLGVDNDDEVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W831</accession>
    <name>R4W831_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445153.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01530"/>
    <dbReference type="EnsemblBacteria" id="AGN00259">
        <property type="protein sequence ID" value="AGN00259"/>
        <property type="gene ID" value="L593_01530"/>
    </dbReference>
    <dbReference type="GeneID" id="16180126"/>
    <dbReference type="KEGG" id="sali:L593_01530"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="274"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="664" mass="72347" checksum="9AF4A1622E027502" modified="2013-07-24" version="1">MPHRKIWDIDHPPVALLVGTDARTSDLATAVEGSVELQIERVADRSAALDRLAERPVVDCCWIAADSPTELWLEFLESVANEAPLTRIVYAPEAGDIDLADRATALGAADVVAPATTIDERATRLVDAVDQAVDRRHDAVERSILDSIVDGLDVSVFAKDDKARHLVYPSDTTTGEGRELFGLTDLEAFGTNDETLSDAYQDDLAVIREGRNVLGKVERYPDFQQGWQWTSKVPWIEDGETRGLVGLTMEISEWKNRERALLQQVGYLQRIPKYLTHDLRNPLAIARGYVQLAREGEPGALDTVEEALDRMSDKLTEFHGLVDGSASSEQARSPVPFARTVEEVWDHVSLPGTELILEADPDARLLADEDQLRPLLQNLFRNAIDHAGPRVTVRVTLTRDGFVVGDDGPGLGDWSDEDVFATGTTSASNAAGLGLAIVREVAHLHGWQVETGRSDLGGASFTFSGCLLGRLSGADVGDERFELEDSRDVGDVSVAGSTRTDGDVATLRGAGANVWGKVNEFHFAHATVTDDVRIEARVTEMDVASEHSKAGVMIRSGLDEDAAYGAICRIADQCPEVLWRDAPGERGYSVQAEGVEQSFDWIAIDRVGDECYTSISVDGDVWIPIDDRSLDLSSEVAVGLFACSAAEGEAIEARFEDLSIRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W832</accession>
    <name>R4W832_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445158.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01555"/>
    <dbReference type="EnsemblBacteria" id="AGN00264">
        <property type="protein sequence ID" value="AGN00264"/>
        <property type="gene ID" value="L593_01555"/>
    </dbReference>
    <dbReference type="GeneID" id="16179861"/>
    <dbReference type="KEGG" id="sali:L593_01555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.316"/>
    <dbReference type="eggNOG" id="arCOG00932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053467_0_0_2"/>
    <dbReference type="OrthoDB" id="85003at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040087">
        <property type="entry name" value="MJ0021-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43288:SF1">
        <property type="entry name" value="PTHR43288:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01108">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="331" mass="38171" checksum="CBDEBDE7359749FF" modified="2013-07-24" version="1">MISEGCEQCAKGGKLVLFVYGYCDERDCFYCPLGENRKNVTDVYANERKVESDEDVLEEAHRMDALGSSITGGEPQEALGRTCHYLELLKDEFGEEHHTHLYTGITGGRENMRRLSEAGLDEIRFHPPLEQWGDLHGTEWEDILYIAREEGLTPAFEIPGIRAEEEFLEFLDEGAADFCNVNEFEMSDGNFRRMQEEGFERKEDHMSAVADTRDEILDVMGDHERVYFCTSVFKDAAQHRRRLKRMARNVRRPFDDVTDDGTLVYGKTWADPERFEALGVPEEFYTVKSDHVEVAWWLLEEMVADGDLERGEIVEQYPNYDGHVVERTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W854</accession>
    <name>R4W854_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_01890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01890"/>
    <dbReference type="EnsemblBacteria" id="AGN00329">
        <property type="protein sequence ID" value="AGN00329"/>
        <property type="gene ID" value="L593_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_01890"/>
    <dbReference type="eggNOG" id="arCOG02770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061949_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="38709" checksum="9D7CD08FD8658444" modified="2013-07-24" version="1">MGFVLFLVLGLSWLTSGRIGRRDPRIEEWTQPERSEREEPSNDADGRPVEDDGRPSADEAPSEDVSSQTDGAPTGTASNDTASIGTASTERGEENEWGSTNRGAPPNDRSARNERPASTSEDDARAREPDARVTESDARTFEPDSGTTQSDSAGTEPDRAIETAAVRSGPADGDGLDSIPTAALLANVLLTHGGLGLLVLGAAALTGIPAATLGVDGSAWSTGALAVGGGLAFGGALAALNVALAASLDRIGVDYSEALRAALAPDSALGWGVLLLLILPLVAGFEELLFRAVLIGGAAAATGLSPWLFVVLSSIAFALGHGVQGKGGIAVTGLLGGVLGVAFVLTNSLVLVVIAHYVVNAVEFLLKEWLGWNLDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W872</accession>
    <name>R4W872_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01538">
        <property type="protein sequence ID" value="AGN01538"/>
        <property type="gene ID" value="L593_07965"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1632"/>
    <dbReference type="eggNOG" id="arCOG06346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211275_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043902">
        <property type="entry name" value="DUF5786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19099">
        <property type="entry name" value="DUF5786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5786" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="57" mass="6681" checksum="98CD8C7575C2510F" modified="2013-07-24" version="1">MSMGAYDEDEHERRERKSNTVDAAFDDDRHEYEGSMEYDSGDSAEDLLDQFEEIKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W882</accession>
    <name>R4W882_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02290"/>
    <dbReference type="EnsemblBacteria" id="AGN00409">
        <property type="protein sequence ID" value="AGN00409"/>
        <property type="gene ID" value="L593_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02290"/>
    <dbReference type="HOGENOM" id="CLU_938818_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="296" mass="31095" checksum="6CCA022049DAB7FD" modified="2013-07-24" version="1">MGWKYNLYSALPIFVFLILGVPAALIYSGNAEPYVEASQMPVHAGYGFIGLIGSVFATAIFSGILVNRSFVRTGKSLGLSKEGGGLFGGPPNFVGEKRGRPVRVETWKERHSSGGEGGTSTTTHTRVLAELDRPMSEGFILIEEGSGSDADAMDDVPDEAEVVPVGDGYAVIGAANEPIAREILTQEVDLALQVPGSPDGVTVGDPAETILDALPEDLSTMGGFFGNAIEERLREEISADPATVSDERRGLPLVTDRLEARIDAMVTVAEAVDAADAAKRRTGAEQTTGDGAERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W883</accession>
    <name>R4W883_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactoside O-acetyltransferase 3 maltose O-acetyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.469"/>
    <dbReference type="eggNOG" id="arCOG01850">
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    <dbReference type="OrthoDB" id="105089at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Hexapep"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="175" mass="18974" checksum="2F261CC1A63FA3A1" modified="2013-07-24" version="1">MSDDEAERRHHGLSRHPTTGPRNSLYHWPDAKHPLRVMLNYAVIVLCRISPSLRLKNWLLRRIGVGVGEGVAWGLESTPDVFWPELITVEKHAIVGYDATILCHEFLQEEYRTGEVVVGERAMIGAGAIVLPGVEIGPGAQVAANSLVAEDVPADATVAGVPAEPIATDEAQDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W889</accession>
    <name>R4W889_9EURY</name>
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        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">L593_02390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445323.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02390"/>
    <dbReference type="EnsemblBacteria" id="AGN00429">
        <property type="protein sequence ID" value="AGN00429"/>
        <property type="gene ID" value="L593_02390"/>
    </dbReference>
    <dbReference type="GeneID" id="16181466"/>
    <dbReference type="KEGG" id="sali:L593_02390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.485"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1297459_0_0_2"/>
    <dbReference type="OrthoDB" id="59560at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="221" mass="23746" checksum="F31AFBFEBB2B5454" modified="2013-07-24" version="1">MIDECLGVEVRIEGDGCPLADATRATGASVDARPPLLRADGNALLRFSGPARDDLADALDADDRIRYLYRSRTDDRHTFRCLSTRPCVVHDLISAGFLVDSLAYGPERTAVTGAVVGQDVLQGVMETAGETVGVELERVYPLGPEDDAPVARRWDLTPAQAESLRTATAMGYFTVPRRTTASEVADAMGISKTAFLERLHRAQHALCSQAFDVDAPPASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8B8</accession>
    <name>R4W8B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_08490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446537.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08490"/>
    <dbReference type="EnsemblBacteria" id="AGN01643">
        <property type="protein sequence ID" value="AGN01643"/>
        <property type="gene ID" value="L593_08490"/>
    </dbReference>
    <dbReference type="GeneID" id="16182433"/>
    <dbReference type="KEGG" id="sali:L593_08490"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1739"/>
    <dbReference type="eggNOG" id="arCOG02764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_4_2"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="792" mass="81526" checksum="CD7AB1BA08E8EF03" modified="2013-07-24" version="1">MTADAADGAAGRDDGAAGGDDATAELRLSVPDMDCASCAGKVEHAIEGIDGVAAFDTRPTTGTLKLTYDSAGISIEEIVASIEAAGYEVVDAPSESGGGAADRDGDGADDHATDAATEQRLLTSSRAVKTWIAGALLAIGLGLEFVVAGADPQVATVLGSELHLADVLFVGAVSIGGQEILRGGVVSARQRNLDIDFLMSTAIVGALVASVGFGEALYFEAATLAVLFSIAELLETASMQRARSSFEELVELSPEEATVWRDGEEVTVPVGALEIGEVVVVRPGEQVPTDGEVTDGESAVNQAPITGESVPVDKTVGDEVYAGTINEEGYLEVQVTAEASDTTLSRIVELVEDAQANKTEREQFVERFADYYTPAVVAFAILVTLGTPFLMGVTWPTAVVYGLTLLVLACPCAFVISTPVSVVSGITSAAKNGVLIKGGNHLEAMGAVDAVAFDKTGTLTKGALTVTDVVPLNGNSQEDVLACAHGLETRSEHPIGEAIVAEAGAAGVASGNRAVDDFESITGKGVRAELGGTPHFAGKPGLFDELGFDLSHVHATTDGGVVTRTARQICDRNNCLDLLEETVPELQAEGKTVVLVGTDDELEGVIAVADEVRPEAKRTIERLRDLGVDRTVMLTGDNERTARAIAEQVGVDEFQAELLPEEKVEAVEKLDADTEGGVAMVGDGINDAPALATATVGVAMGAAGTDTALETADVALLSDDLSKLPYLYELAGDANGVIRQNVVASLGVKAGLALAVPFGLVPIWLAVLAGDAGMTIGVTGNAMRLSRVEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8C3</accession>
    <name>R4W8C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01653">
        <property type="protein sequence ID" value="AGN01653"/>
        <property type="gene ID" value="L593_08540"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_08540"/>
    <dbReference type="eggNOG" id="arCOG06413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="176" mass="18003" checksum="F82D1C9916C444BD" modified="2013-07-24" version="1">MDRVPIVQSAVAGLGAYVASFALVAIVVAAMEDGDDLVGGAGNILYGAHFVDSKSTVSMMGQTQSQTSNFVSEASLEAPELLYQIIPIVVLVGAGIALVRTFDIQDETDAAIAGAATAIGYVVLTVVGTFVFEMSESQQGISVDVAPELGLVTVLLMGIVYPAVFGGIGGFVGTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8L1</accession>
    <name>R4W8L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446802.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09815"/>
    <dbReference type="EnsemblBacteria" id="AGN01908">
        <property type="protein sequence ID" value="AGN01908"/>
        <property type="gene ID" value="L593_09815"/>
    </dbReference>
    <dbReference type="GeneID" id="16182818"/>
    <dbReference type="KEGG" id="sali:L593_09815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2020"/>
    <dbReference type="eggNOG" id="arCOG02866">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172273_0_0_2"/>
    <dbReference type="OrthoDB" id="112906at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="8500" checksum="D2A1279190C28AC4" modified="2013-07-24" version="1">MAQFTEAERRIVAYLADSAARGERYFRSRNIAEALGLSSKEVGVRLPELDEKTEDIDIEKWGRARSTTWKVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Q1</accession>
    <name>R4W8Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445713.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04340"/>
    <dbReference type="EnsemblBacteria" id="AGN00819">
        <property type="protein sequence ID" value="AGN00819"/>
        <property type="gene ID" value="L593_04340"/>
    </dbReference>
    <dbReference type="GeneID" id="16180910"/>
    <dbReference type="KEGG" id="sali:L593_04340"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_4_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15140" checksum="0C922878354F2823" modified="2013-07-24" version="1">MERVLVAMDESEPAERALEFALDELDAPSVTVLHVVGVPSMLMGEATALAFEDDLETAANERAAPVFERAREIASERGREIETVVGVGHPARNVVDRSEDYDAIVVGSHGADRGRASHRLLVGNVAETIAKRAAVPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8S9</accession>
    <name>R4W8S9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="3">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="3">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sucD</name>
        <name evidence="8" type="ORF">L593_10565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446952.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10565"/>
    <dbReference type="EnsemblBacteria" id="AGN02058">
        <property type="protein sequence ID" value="AGN02058"/>
        <property type="gene ID" value="L593_10565"/>
    </dbReference>
    <dbReference type="GeneID" id="16181617"/>
    <dbReference type="KEGG" id="sali:L593_10565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2178"/>
    <dbReference type="eggNOG" id="arCOG01339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_2"/>
    <dbReference type="OrthoDB" id="37867at2157"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="3 4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="29738" checksum="5E7B8CAE8750A3B4" modified="2013-07-24" version="1">MSVFVDEDTKVIVQGITGGEGKFHAGQMIDYGTNVVAGAVPGRGGQEVHGVPVYDTVERAAKEEDADASVIFVPPAFAGDAMMEALDAPIDLAVAITEGVPTQDMARVRKRLTEVDTNLIGPNCPGIITPGESKLGILPGNIFSEGNVGLVSRSGTLTYQVVDNLTERGLGQSTAIGIGGDPIIGTTFVDALEAFENDPETHAVVMCGEIGGEDEEQAANYIGQYMDTPVVGFIAGRTAPPGKRMGHAGAIVSGSGTGTAQSKIDALNEAGAQVGDTPEQVAEAIEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8U0</accession>
    <name>R4W8U0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_04875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445818.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00924">
        <property type="protein sequence ID" value="AGN00924"/>
        <property type="gene ID" value="L593_04875"/>
    </dbReference>
    <dbReference type="GeneID" id="16181325"/>
    <dbReference type="KEGG" id="sali:L593_04875"/>
    <dbReference type="eggNOG" id="arCOG00562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467441_0_0_2"/>
    <dbReference type="OrthoDB" id="6691at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="132"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="583" mass="63876" checksum="BFBCC04A8929C0B9" modified="2013-07-24" version="1">MNRDRIRREIQANPWLTGVLVLAAVLLYFGIWRIAPYQMIPDEVAATTQPLTIAREPYGMTEFKKGGNLHIWLLALAYVVVMLPVGAYWFATGQIQAVLDEANRVSQYTDGGQWAEANQQLLETYHLLVRTGRLVSATAGLLTVLGVALLARRLGGKPAGVIAGTTLSVSLGFVLTAKYATEDVVVACFAVWTFLLLVWHHDTGEDRYLLYGAAATGLAISTKATAGVLVFVVAILAFRRYEPAELLSADAIRDLVRYPVAAIATYVATTPSLLVHPGRYVDEIARYFTVKSGGATFYAANEPGWIAHLGHLVTALGVPLLALVILATIGVAVLAVTDRVSRFTLYPLGFAVAFFLVDSFTSSTQYNRILLIVPLLAVFVGLVGAWAIDAERPREFHTVARAALAIVLLLSLFYTASGAMVWSTSRGEATEWLDGNLEDGAEVTVLTKPVYLPAFPETVNVTRASVDPLYDRHTDARKERVLERVRCHETDYLVLSSFHYERYVEDPVISPNRTAFFDSLLAGEEGYRVVAEFGPSDPNLQRDAEANFERALRLEPPSRNTNNPRIIVMEPTVPEGEGANCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V3</accession>
    <name>R4W8V3_9EURY</name>
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        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05050"/>
    <dbReference type="EnsemblBacteria" id="AGN00959">
        <property type="protein sequence ID" value="AGN00959"/>
        <property type="gene ID" value="L593_05050"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1030"/>
    <dbReference type="eggNOG" id="arCOG01589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609183_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008503">
        <property type="entry name" value="Put_Zn_protease"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05618">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="129"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="473" mass="50615" checksum="29776F143E9D6A3B" modified="2013-07-24" version="1">MSGDAADLSGDSGDQTTAVAATAAAAADEPARVGVLSLHTSKETKAICNAIEALGHEPVWLRAENLAVSIEDGEVALEPEVDAICNRLLLSNTEEPAEGLGLAMTLNRIRPMCNEPGPVLAALHKFATATTLADWKVQVPDALLALSNERLNRERDRFGDVGVYKTAIGTHGGGTWKVNLDEPVNPMVGRRMAFLQDLIERDDEAHRDARVYVVDDEIVGAMYRYAPEGEWRTNVALGGDVQDATEDLPEEARDTALYAAEVMELDYAGVDLIQGHDGWFVLEVNPTAGFKGLFEATGHSPAPYIAKLGIERAGGEVDEERVQELSNTLDDSRPSCAPRPDPTAGNAPAPTIGYTEEVVVSGTSGSTTTLAKSDTGATRSSIDTALAAEIGAGPIKSMTRVKSGSVKEGKARPVVDLVVGIGGTQHTVTASVEDRSHMSYPLLLGRDILQHYQVDVRRRVDKDEPDEQELEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W961</accession>
    <name>R4W961_9EURY</name>
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        <submittedName>
            <fullName evidence="7">K+dependent Na+ exchanger related-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_12395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12395"/>
    <dbReference type="EnsemblBacteria" id="AGN02418">
        <property type="protein sequence ID" value="AGN02418"/>
        <property type="gene ID" value="L593_12395"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12395"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2549"/>
    <dbReference type="eggNOG" id="arCOG02881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="336" mass="35031" checksum="709DD62554DAF399" modified="2013-07-24" version="1">MDAVHHDEDARTGKTAIECRERCRSTTGRAPVIVELVGMLAGLALLLLGADRTVREAGELALYYGVSGFFVGVTVISIGTSIPEMTTSLYGAYYGAGDLVVGNVVGSETAQITLAIGIVAMISPIVAERRNVVLYGGAMVLAMIIMILTLEDGITRSEGFLMMLAYAIFVHDLYSNEGGKEITEEVIGEQRPPSKTVPWIVAGLGLVVAGGYLLVTNAADLARTLGVPAYLLGLLIGLGTTTPEIAVAGVAAKRGDGGISVGSLLGSNITDPVFSLGIGALVADVTVTDPAAVYLSAGYMLGVSGLVLGLLYWRRGITRRTAVLCMLAYLPAFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W970</accession>
    <name>R4W970_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PglZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446113.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06360"/>
    <dbReference type="EnsemblBacteria" id="AGN01219">
        <property type="protein sequence ID" value="AGN01219"/>
        <property type="gene ID" value="L593_06360"/>
    </dbReference>
    <dbReference type="GeneID" id="16181678"/>
    <dbReference type="KEGG" id="sali:L593_06360"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1296"/>
    <dbReference type="eggNOG" id="arCOG05218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383408_0_0_2"/>
    <dbReference type="OrthoDB" id="28954at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="464"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="719" mass="80661" checksum="BE147C58C870CDFE" modified="2013-07-24" version="1">MPATKTIPQAAEDAIQTRIEGAPDEEPVVLWWDDGGHLREIVESVSDSLGCEFHAAETTPLELRADAPRDRTVWYVPQAPDDDVDWFRDVENTGGVVEAHIGKLAARCFQNDRINAASIRTAYESSDERDREQIARTLYDALDGEGGLPTLQSLQTQIVLDGHDDPVAFVLEHGEANLPEDTDDLLEIRDLLVDDGVTAVEGVTEAGALVERTRRWAVAEWLVDEGLDPSLLESGYRPEPDSGLGVSRPELQSMLSKTERKAELAETYLDPGARYWHDVLRTLDDPWELADCPVDAALEHELWDAWTRAFNDGEYDTCADRATRRHERLEATYDDVPWTVVWEQAIDVANLAAELQDWAESTDVDDVVEVYGDVEDGTWQIDNAVFNLITSGEPESDLPEEHPATASLDDLRTSLVESRYLEYLGDLGDLVVDQIETGSPFVGENFAHQFFDQEQEHLQSGQSVALFVVDALRFDLAHELAESVRRALPGLEVDESAWVGTLPSDTDFGKAALTPGSKFSFNVTLDDGELVPERNGRKITNYQREKLLTDDGWSYIMQSDDEKVGWGENRVAYYWNDLDKAGEEELTDFEHVFSDRIETISEIICEKLQKGEWDRAYILADHGFVSLPRQIDIDDIHPPDGAEHVTRRWVAGEDLDDDGPGVLLDENAHLGYLDGETKIRALADPIQRFRNQGLPDARFYHGGVLPQEFVLNFVTITQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9C6</accession>
    <name>R4W9C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_13095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13095"/>
    <dbReference type="EnsemblBacteria" id="AGN02558">
        <property type="protein sequence ID" value="AGN02558"/>
        <property type="gene ID" value="L593_13095"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_13095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2684"/>
    <dbReference type="eggNOG" id="arCOG00086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="26036" checksum="B1B67E254261F033" modified="2013-07-24" version="1">MSTEPSEASDAVERTVPEPNPDTVPDVEILVVDNYDSFAYNLVQYVGELAGEVVVRRNDAIDVADVRTLDPDGVIVSPGPGHPEDAGVSMPLFAETAVPALGVCLGHQALCAANGAIVELAPDVVHGKPSVIEHDGAGLYRQLPNRLRVGRYHSLAVDRSELPAGLAETATTTDDDGSVLMGVRHRERPHFGVQFHPESILTGEVDAEEGASLAVGKQLVAQFCRLAAEWQAGDGTKRTGGSGGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D1</accession>
    <name>R4W9D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447462.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13145"/>
    <dbReference type="EnsemblBacteria" id="AGN02568">
        <property type="protein sequence ID" value="AGN02568"/>
        <property type="gene ID" value="L593_13145"/>
    </dbReference>
    <dbReference type="GeneID" id="16180401"/>
    <dbReference type="KEGG" id="sali:L593_13145"/>
    <dbReference type="HOGENOM" id="CLU_2565894_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="81" mass="9375" checksum="F1FE30ED50C6F575" modified="2013-07-24" version="1">MPETASIHSFIKSHQALIDLLTELDDQRTAYEISTAFEAAGRDIREEFEIEFEELSDREIGMFVTAWEATHLDQNDQRMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D4</accession>
    <name>R4W9D4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="12" type="ORF">L593_07285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446298.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07285"/>
    <dbReference type="EnsemblBacteria" id="AGN01404">
        <property type="protein sequence ID" value="AGN01404"/>
        <property type="gene ID" value="L593_07285"/>
    </dbReference>
    <dbReference type="GeneID" id="16179990"/>
    <dbReference type="KEGG" id="sali:L593_07285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1487"/>
    <dbReference type="eggNOG" id="arCOG02741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_2"/>
    <dbReference type="OrthoDB" id="25235at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
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            <name>[4Fe-4S] cluster</name>
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    </evidence>
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    <sequence length="483" mass="52818" checksum="E7F1774301632FAB" modified="2013-07-24" version="1">MPRTQLQRARDGESTPAMERVAERENRDPEFVREQVAEGQAVIPSNHGHDSLDPMIIGREFSTKVNANIGNSETTSDLQGELRKLHTAVHYGADTVMDLSTGSNLDEIRETNVEYSPVPVGTVPIYEAVKEAGSPEEMTHELLLDVIEKHAEQGVDYMTIHAGVLMEHLPLTDGRTTGIVSRGGSILAQWIEENGMQNPLYAKFEEICEIFAEHDVTFSLGDGLRPGSLADASDEAQFAELETLGELTRTAWDHGVQVMVEGPGHVPMHEIADNVERQQEVCDGAPFYVLGPLVTDVAPGYDHVTSAIGATEAGRAGAAMLCYVTPKEHLGLPDEEDVREGLAAYRIAAHAADVANGLPGARDWDDALSEARYEFDWRRQFDLALDPKRAQDYHDQTLPGDNYKEARFCSMCGVEFCSMRIDQDARDVADGEMDAIENRTDLDASAAAEVNLPPAGTHDTSSVPDLPEFVDSEGVHPEEPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9I3</accession>
    <name>R4W9I3_9EURY</name>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000014072"/>
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    <sequence length="100" mass="11204" checksum="5ED0E993990576E7" modified="2013-07-24" version="1">MEVWLNAARAAAGVNVLLLLALGSVWLRGYRSHGASHTLGLLVFAVMLLVQNLLWLYFYVLHPDFIEWFRVTGTDVQVGITLLCGLELAALAFLSWITFR</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="368" mass="40432" checksum="33C1B15DE4CD0CFF" modified="2013-07-24" version="1">MGLEEEIEELREEISETPYNKSTEAHIGRLKSKLAEKKEELAKRQQSSGGGGGYHVEQHGDATVALVGFPSVGKSTLLNALTNADSEVGSYEFTTLDVNPGMLDFRGASIQLLDVPGLIEGAAGGRGGGQEVLSVVRSADLIVYVLSPFELEQYDLLAQELYDNKIRVDQVPPRVSVVGKGKGGIDVTASVDLDLDEATIKNVVREHGYVNADVSINEQVDIDRLIDGVMENREYVDSLTVVNKADLIDPSYVDTVKEGLRERGIDPEEAIFISAEEEKGLDSFKAELWDALGLIRIYMDKPGRGVDYDEPLILREGQTVGDAVEKLGFDDRYRMSRVTGPSGQHDEQQVGLDHELMDEDVLRLVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9U0</accession>
    <name>R4W9U0_9EURY</name>
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        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">L593_09220</name>
    </gene>
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        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09220"/>
    <dbReference type="EnsemblBacteria" id="AGN01789">
        <property type="protein sequence ID" value="AGN01789"/>
        <property type="gene ID" value="L593_09220"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1893"/>
    <dbReference type="eggNOG" id="arCOG04615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018666_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="108"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="754" mass="81679" checksum="6F08CA4EF8EDAFBC" modified="2013-07-24" version="1">MSSDRARSLLARLRSDVHARLRLREQPPERLAAALLALAAGALTFWIATDLFPYHSANHDEGVYLQQAALFLDGRLSLQAGPVADAVRPWFFVQDGGRLYPKYQPYPALLYAIPMGLFGAPRLALAFVAAANVALVYALGAQAFDRRIGLLAAAAFATTPTTLLTTSVFLPYAPTTMLNLAFAVCYLRAYRRRSVAWGIVAGLAIGLAFFGRPYTALLFAAPFVTHACWQIATSLRAADRTALLRGTTVRERWHTLPEALRRNTGTAAVGLAFVGLTLAYNVVLTGSPFRFPFTAFAPQDGPGFGHREIVGHGIDFTVALGIESSAHVLWGLATRWGPAGPVGTLLAIGGLAMAARRWEMERFRRLADRQPFEHTGQQLLAGLFVTVIAGNVAFWGNHNILADFDDPTDGLLGLFGPFYHFDLVAPLSIFAAAGLVGAWRWVRAWDPDPSASAGFGGRTAATGLAARLTAIASPRALRAVALASLLLLAAVGGAASAALVQGPVDRHEQRTDSLESAYEPFEERSFDDAVVFVPTPWGDWLNHPFQPLRNDGRLDGEVVYAMDRHTASDFAVLEAFPERTPYRYTYRGEWTPGDEPVEPRIQRLDVRTAESFTGQMVVGVPARIDHAAVRLETDGDAFATYRVDEPDDSIAVGWSLGAGGARLERPDGTAGEQLPIEAYDEVALQVRLVAADGSTLTYRQEVDVRRSGTSVSVIWPPERTVCTLVDDCGLEGTYLPEDPDAHGPGVSFETRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V9</accession>
    <name>R4W9V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446778.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09695"/>
    <dbReference type="EnsemblBacteria" id="AGN01884">
        <property type="protein sequence ID" value="AGN01884"/>
        <property type="gene ID" value="L593_09695"/>
    </dbReference>
    <dbReference type="GeneID" id="16182787"/>
    <dbReference type="KEGG" id="sali:L593_09695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1996"/>
    <dbReference type="eggNOG" id="arCOG06437">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100990_0_0_2"/>
    <dbReference type="OrthoDB" id="112252at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="252" mass="27121" checksum="B9762991DD668CAE" modified="2013-07-24" version="1">MSAATDRLRRIDVATVGIAIAAVVAVVGIASVFSTVFDFSGLYEDRTRVLLGFAGIAVGAFLAKRWIDTDPGSYRPPERERVLAVDVPGEEFDDLLRFRAIAKSPEAIRYFRSQSREELQQVAIEVLELHQGLDRETARARLRGGSWTADETAAEFFRLGTDGGATEELDNALRRRRGGEHPHTKRARRAVEALARIAGPGTDRSAETDADRTAGTAEPPASETAGTGTTATGTAATERDPTGPAAAEEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA32</accession>
    <name>R4WA32_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="10" type="ORF">L593_11530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447143.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11530"/>
    <dbReference type="EnsemblBacteria" id="AGN02249">
        <property type="protein sequence ID" value="AGN02249"/>
        <property type="gene ID" value="L593_11530"/>
    </dbReference>
    <dbReference type="GeneID" id="16182597"/>
    <dbReference type="KEGG" id="sali:L593_11530"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2377"/>
    <dbReference type="eggNOG" id="arCOG00641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_2"/>
    <dbReference type="OrthoDB" id="860at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="9">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="79"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="205"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="463"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="751" mass="77815" checksum="A248AEDC937CE40E" modified="2013-07-24" version="1">MPLAEADRELVVDELGREPTRAEAALFENLWSEHCAYRSSRPLLGAFDSEGERIVVGPGDDAAVVALPDPLAEEVADAAGDLSDAPNGDVYVTLGIESHNHPSYVDPYDGAATGVGGIVRDTLSMGAYPIALTDSLYFGDFDREHSRYLFEGVVEGIADYGNAIGVPTVGGSVDFHPDYEGNPLVNVACVGLTSEDRLVRAAVNEPGNKLVLVGNSTGRDGLGGASFASEDLDEDAETEDRPAVQVGDPYTEKLLIECNEQLVDEDLIEAARDLGAAGLGGASSEMAAQGGLGAEIDLEQVQQREPNMNAMEILLAESQERMCYEVTPENVERVEAVADRYDLGCSVIGEVTEGNYVCTFDGETVVDADAEFLGDGAPFNDFPMEEPESQPRDRPEGVDLQDAFEAVLASPNTASKEWVYRQYDHEVGTRTAVKPGDDAALMTIREAAGIHEDGDASGQGVGLAISAGAAPNWTDANPYEGARAVAVENATNLATTGATPLAAVNCLNGGNPEKPDVYGGFGAIVDGLADGCAALDSPVVGGNVSLYNDSVAGPIPPTPTLAMVGTRKGYDTPGIAAESEGKLLLVGGPALDEDGDAIEQSDAGQDLGGSEYLAQVGGTDRFPAVPDDPSATVTAIAEVARQDATLAVHDVSHGGLAVTLAEMVTEDAGLDVALPGEDPAGELFSEAAGRALVQTTDPAAVEAAFDGIAPVSRIGAGSDDGRLRIAAGDHEIVLAADEIAGQRSTIDRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA34</accession>
    <name>R4WA34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_11580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447153.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11580"/>
    <dbReference type="EnsemblBacteria" id="AGN02259">
        <property type="protein sequence ID" value="AGN02259"/>
        <property type="gene ID" value="L593_11580"/>
    </dbReference>
    <dbReference type="GeneID" id="16181442"/>
    <dbReference type="KEGG" id="sali:L593_11580"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2387"/>
    <dbReference type="eggNOG" id="arCOG02276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010057_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="184"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="370"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="887" mass="98996" checksum="78AD0E7C25F47111" modified="2013-07-24" version="1">MSTSALTDALEETLAVFEGHTDGEPLTTSEVADRLEMGRRSTYDRLDRLAEREYIETKEVGARGRVWWLPRDPAGGDASEVGEHDPGSGNAGDGRERVAADSTGAMGDTARSFEALVDAVEEYAIFHLDPDGVVTTWNAGAESIKGYERDEIVGRSFETFYTDDDLAEAVPQNNLEAAAREGWIEDEGWRVRKDGSRFWASVTITALYDEGDLAGYAKVTRDMTERRTFEERLRQQRDDLESELDEVFERVDDAFLALDQEFDVSYVNDSATELLETTVGDAVGAPVWDLLPDLADEQHRSRIEETAARGESLEFVCYCDLLDHWIEVRTYPSASGLSIYLRDVTERRQREQELERHEAIVETVDEGIYVTSNGEFTMVNDEYAEMTGYDREELLGAPVSMVADEATIERAREYERELVEGDRDSARFEADLVRADGERIRAEATFAVLPDEATPNGDGAESPTERVGVVRDVTERVERERKLQRRRERLEALDDLNAVVRQITTDAIEQSTRAEMEETVCEGLAASDSYQFAWIGDVDVGSQTVSLRTEAGVEGYLDGVTISVDPDDPHSQGPAGQAFLTESVQTSRDAQAESRFEPWEDVLDSHGFRSSAAVPIVHEESMYGVLNVYTDRPSAFEGEERDVIEQLGTVLGHAIAALERKRALMSDEVVELEFRLSDVSSKLELGGPDRGHFALDRTVSIGDSQFLLFGTADDPGVELLEALVATLPHWDGVDVFDDHGDERRVQIRLTESPVLAPIASRGGIVEEFHIEDDDMHFRVQMAPGGEVREIIDVIQDRYPAAKMLSRRQIGRPDHGSARFDRTVEGTLTERQQAALEAAHAMGYFERPRRNSGQEIAETLDVTPATFHQHLRKAERKLIDAALDGSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF3</accession>
    <name>R4WAF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447748.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14590"/>
    <dbReference type="EnsemblBacteria" id="AGN02854">
        <property type="protein sequence ID" value="AGN02854"/>
        <property type="gene ID" value="L593_14590"/>
    </dbReference>
    <dbReference type="GeneID" id="16180110"/>
    <dbReference type="KEGG" id="sali:L593_14590"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2979"/>
    <dbReference type="eggNOG" id="arCOG04463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053464_0_0_2"/>
    <dbReference type="OrthoDB" id="105011at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010545">
        <property type="entry name" value="SPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06550">
        <property type="entry name" value="SPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="372" mass="37646" checksum="FE8C640689E96D18" modified="2013-07-24" version="1">MDDRTRSMVAVAGTIGLFLCVQLGALALLDPYVAADAQPVDDPSNASNVAYFFGVILVATAGMLAAIKFGLERLIRGFVLLSCGWISWIVLDTILASLGADSVGTGTASTAIEALAFIVPFAVAATLVVALFVHPEWYVIDVAGVLLGAGAAGLFGLAFTPQLTIVFLVLLAVYDAISVYGTEHMLTLAEGVSDLNVPVMLVVPTTGSFSLLTDTGPSSLDGDETATGESATESTGAEPAETTVEAPQGGDGPGVEQAASEDDYPAANDGGGRNAIYIGLGDAVMPTILVVSAAYFLRDSAPLYDVPILAINLPALTALLGTLVGLGALLAMVLKGRPHAGLPMLNGGAIAGYLIGALASGIGVVEALGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSX2</accession>
    <name>R4VSX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445179.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01660"/>
    <dbReference type="EnsemblBacteria" id="AGN00285">
        <property type="protein sequence ID" value="AGN00285"/>
        <property type="gene ID" value="L593_01660"/>
    </dbReference>
    <dbReference type="GeneID" id="16179901"/>
    <dbReference type="KEGG" id="sali:L593_01660"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.337"/>
    <dbReference type="eggNOG" id="arCOG06368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118238_0_0_2"/>
    <dbReference type="OrthoDB" id="83608at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="248" mass="26278" checksum="19638502801FFED8" modified="2013-07-24" version="1">MAAGSARGGVLDGVKIDLRRLHDTWMELIFPRQRQAHSVLGRWTPNTTSGQILYKIWGALGILMVGILYPLALFGVVTRFYSRRIDTMIAGIGILGVVLVAAVVWGGLAIAAHFRLSWNGFVAVAAAGGVATISAGIAALCTRYGGRGLTIGIAYPAAMTAIFLPPIVAALFSGVVGDALFPRSEDLAIWLLDNVLFVGGLNEQIRDAFELEGFSYVLMWLGISIPLGWLLGLVVSLAGVIRPSGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUA0</accession>
    <name>R4VUA0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA topoisomerase 1</fullName>
            <ecNumber evidence="11">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">topA</name>
        <name evidence="14" type="ORF">L593_04120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445669.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04120"/>
    <dbReference type="EnsemblBacteria" id="AGN00775">
        <property type="protein sequence ID" value="AGN00775"/>
        <property type="gene ID" value="L593_04120"/>
    </dbReference>
    <dbReference type="GeneID" id="16180866"/>
    <dbReference type="KEGG" id="sali:L593_04120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.837"/>
    <dbReference type="eggNOG" id="arCOG01527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_4_2"/>
    <dbReference type="OrthoDB" id="14543at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="852" mass="94046" checksum="BF9E4C2501CF2AFA" modified="2013-07-24" version="1">MDLIVTEKDNAARRIAEILSDGSADVDRRGDVAVYRWGDRACVGLSGHVVGVDFPPEYSDWRDVEPVELIDAPIEKRATQEGIVSTLKSLAKKADRVTIATDYDREGELIGKEAYELVRDVNEDVPIDRVRFSSITQTEVRTAFNDPDEIDFDLAAAGEARQVIDLIWGAALTRFLSLSSRQLGEDFISVGRVQTPTLKLLVDREREIRAFDPEDYWELFADLEKREDGDTSATFESQYFYLDAEDTEAERVWDEEAAEAVEQVLAADAAAATVEDVNRRTRTDAPPAPFNTTAFIRAAGAVGYGAQRAMSIAEDLYTAGFITYPRTDNTVYPDDLDPEELVSAYEGHPTLGEDAEALLEAGLNDPTEGDDETTDHPPIHPTGEWPDRGELSDDEWEVFELVVRRFFATVADPARWEHLRVTAAVPAGDALSDPAAVLPDGGTEVSLKANGKRLLEAGYHDVYPYFSTSENFVPDVSEGEVLPIDDSRLEAKQTQPPRRYGQSRLIETMEDMGIGTKSTRHNTIEKLYDRGYIEGDPPRPTELAMAVVEAAEEYADTVVSEDMTAQLEADMTAIAEGEIDLDEVTEESREMLDTVFEELVESREEIGDLLRESLKADKALGECPECGEDLLLRESRYGGSFVGCDGYPDCEYTLPLPDSGEPLLLEERCETHGLRHVKMLAGRNTFVHGCPLCRKEEAGEGEILGDCPECGTAHGGELAIKTLENGSRLVGCTRYPDCDYSLPLPRNGEIEVTDETCDQHGLPELLVKDDEDDDEPWELGCPICNYREYQARESESGSDLEALDGVGAATAEKLMDAGVESIEDLVDADADRIAADVDGVSADRLREWKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUI4</accession>
    <name>R4VUI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445769.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04630"/>
    <dbReference type="EnsemblBacteria" id="AGN00875">
        <property type="protein sequence ID" value="AGN00875"/>
        <property type="gene ID" value="L593_04630"/>
    </dbReference>
    <dbReference type="GeneID" id="16181029"/>
    <dbReference type="KEGG" id="sali:L593_04630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.946"/>
    <dbReference type="eggNOG" id="arCOG04649">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154325_1_0_2"/>
    <dbReference type="OrthoDB" id="130130at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043816">
        <property type="entry name" value="DUF5798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19111">
        <property type="entry name" value="DUF5798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="127" mass="13513" checksum="6C8D3E206E2E8262" modified="2013-07-24" version="1">MGLGGTAKKVQKLADTAETLYEQIKDLQRRMVNLEESVDESTARLDRLEKENEKQRLILEAIATEHDVDVESLLAESAIDEAEPVEEEAAAESAADADGTAAAADADSGSPDAGEPTVVDEQGNTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV79</accession>
    <name>R4VV79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446034.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05955"/>
    <dbReference type="EnsemblBacteria" id="AGN01140">
        <property type="protein sequence ID" value="AGN01140"/>
        <property type="gene ID" value="L593_05955"/>
    </dbReference>
    <dbReference type="GeneID" id="16182434"/>
    <dbReference type="KEGG" id="sali:L593_05955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1220"/>
    <dbReference type="eggNOG" id="arCOG01175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069300_1_0_2"/>
    <dbReference type="OrthoDB" id="64275at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="208" mass="22562" checksum="7CDD7DB5EEC20D02" modified="2013-07-24" version="1">MPARLETGIDVLDRKLAGGIPAGSLVAVSADPASQSELLLYQLTNTRGTLYITTKRSDQAVRDAIDSTEAPVGSPTVRDIAGSEPLDQANRLIRALPEGANLIIDPVDVLEHREDARYTNFLNELQTHMVNTGSIAFLHCLDGQNPPDNRDTTEHMADVVFDLDTTTRGSDLVNFLAVPKFRGGQPLTETIKLQLTGEVDIDTSRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV99</accession>
    <name>R4VV99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445085.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01190"/>
    <dbReference type="EnsemblBacteria" id="AGN00191">
        <property type="protein sequence ID" value="AGN00191"/>
        <property type="gene ID" value="L593_01190"/>
    </dbReference>
    <dbReference type="GeneID" id="16182645"/>
    <dbReference type="KEGG" id="sali:L593_01190"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.242"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="143" mass="15299" checksum="974F0005509BE503" modified="2013-07-24" version="1">MIDTVAIATDGSESVSRSVDVAIDLADRFDAEVHALSVVDETEVASSPEQLRDELRAALEADASKAVEGVSERTDREVTTAVIEGRPADAIAEYAREEGIDVVATGTRGRHGEHRFLIGSVAERVVRTCPVPVLTVRQLSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVA2</accession>
    <name>R4VVA2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeosine biosynthesis protein QueC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name evidence="2" type="ORF">L593_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446054.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06055"/>
    <dbReference type="EnsemblBacteria" id="AGN01160">
        <property type="protein sequence ID" value="AGN01160"/>
        <property type="gene ID" value="L593_06055"/>
    </dbReference>
    <dbReference type="GeneID" id="16181619"/>
    <dbReference type="KEGG" id="sali:L593_06055"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1240"/>
    <dbReference type="eggNOG" id="arCOG00039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OrthoDB" id="90765at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="25153" checksum="102EB32F1AD416D5" modified="2013-07-24" version="1">MSENAVILVSGGMDSATAVYEAIHRGYEPYFLHTSYGQETEDKELECARALAEEVEAADFLHVATEHLSAIGDSSLTDDEIDVAEADPDAEGIPTSYVPFRNANLLSMAVSYAEASDCRALFIGAHSEDFAGYPDCRPEFFEAFQQVIDVGTKPETKIDLIAPFVEWSKTDIAERGLELGVPYELTWSCYRSEEPACGTCDSCAFRLEAFQNVGAEDPIEYESRVDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVB9</accession>
    <name>R4VVB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_06130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06130"/>
    <dbReference type="EnsemblBacteria" id="AGN01175">
        <property type="protein sequence ID" value="AGN01175"/>
        <property type="gene ID" value="L593_06130"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1252"/>
    <dbReference type="eggNOG" id="arCOG06444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247239_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="904"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1531" mass="170280" checksum="A27E3A8D811D4895" modified="2013-07-24" version="1">MDTKGPYLEFVSPPATAERPAAELLEQYGYDERVVDAVVDELFGGDRAGSLYQHQVDTIEAIETDPDDNILAVPTATGKTESFFLPVLNDCVATDDNGLKAIVIYPMKTLGVDQLNRFLRYIDTVNQELPREDRVTIGIWDRDTPAAVGPRDYDLDIGANVRGLECPRTQDDLRVTSDGTPGSDDWTYPWLKITREQIRDGVDILLTNPDALDYMFVSDNEATRDILGQGPEKSPVQHVVFDEAHVWSGISGSSIGLLTRRLKQFYAAHDPQVTLVSATIENPSDLASALTGTDRDDVNELGFTARDFPVTGATDFDRFAECSLRDVVETLVLTERHDVDRETFCGSYPQLTGAVTTLEEIGLLAGPDPLTVPDQHRDWVFAPIADSIDTEQEDNTAGAVQNGGTAPGIAPEELDTLTEQVVEHGDLGGRWFQFIRDTVPEVATVASWFMDESTTEVEFEHYADLVNRIEKAGASNPDEAVSALLALGRAAGMVTAKYHMFAKPPRKVYWCQTCEEVTRGRSCPEGHQTRELRFCRTCHHPFVEADTENEDEDDEVFQPVYGGGTDGPCPGCTTLRLRLTDITVPTPTLLSFMLTSLCRSMPSEKTLVFSDSRSTAESVSNEIIGTEYGLTAETLYVKQLIEEGGRAEARSLFYPVLDTLREKYWQPLRQNTPDRETDANDILVELWNEIEPNARLSQCQHLREAALVTPAWVHTCPDPKTAAIGHEVFNLFVSRFPPQFQKHGIKFQGYTRERLVNKLESETRFTEEEIDEVVDDVLQGLLDGDVFELKTWDGVRDTILNAGKDEATEDDVFEYIEDQIDGLEARDGYSDVGGGIFTVHDYASKTDLQLVPQVTFCNDCYTASPVPRHDDGLDHCPTCGNTVDVHQRFRVEDDGSMTLLGWADVETDWEYPVDHWGHDILAPLIPSEGPPVPRDTVEMMELDFITVGIHKGDVPPTLRSAIEEGFRKSDPDINIVSATPTMELGVDIGTLDSVAQVGIPPTLTNYVQRSGRTGRTRGSESLVATTVRGTHPVDAHYYDDLDRFFGSFDPVRVPDPFDFDEVLAGHVVTEVVAYLARNPHPSDTFEETYQINQSVDSVAEFADRVEANLDELRTFVRDDVTDRLRDHIGAVFGQRGLEVFDAVFNSDGPVSFRQRTQQTCGQFRSFSDSTDLDDVRNGNDRLDSWLNRLGYLANYREFGQQFPVQFEGSSESISFQGDGRLYDFYPGEENERGAVMTLYGSTYLVSDVEGTKEPLQTVAICTNEDCTRPFESYRTAAEQCPHCGNPLDAISVHGVQAVNCRKAHQFEDLYSTSPIMTTHVTSRGERTAGEETTVFGLSCDVAVGGYDVIDFIPVFERRHTMGSGKEIKRSEARIPDSDDARYAPVGKQYVTQGICLTFDQAAVADRLPDEALEQEDEAVWPQLFISLEQALTKAVAVETQSDQDDFRVKVTATGDEIRVYIVDNRQGGNGIATQVDRHLDAIVDEVRNVIDCDECSGYCENCLLIERTPATYLDNDLLNRTLLAEAVGQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVK7</accession>
    <name>R4VVK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445180.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00286">
        <property type="protein sequence ID" value="AGN00286"/>
        <property type="gene ID" value="L593_01665"/>
    </dbReference>
    <dbReference type="GeneID" id="16179903"/>
    <dbReference type="KEGG" id="sali:L593_01665"/>
    <dbReference type="eggNOG" id="arCOG04509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6737" checksum="654A84B48C743AAB" modified="2013-07-24" version="1">MVEFNAVTTAVAFLAVIVVGIGGLLGMGFMTFRTTMMMVAPSMAIFGLICLAIGVQFGEYRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVV5</accession>
    <name>R4VVV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445285.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02200"/>
    <dbReference type="EnsemblBacteria" id="AGN00391">
        <property type="protein sequence ID" value="AGN00391"/>
        <property type="gene ID" value="L593_02200"/>
    </dbReference>
    <dbReference type="GeneID" id="16180564"/>
    <dbReference type="KEGG" id="sali:L593_02200"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.446"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_2"/>
    <dbReference type="OrthoDB" id="53218at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="320" mass="33374" checksum="37211DF1718DAD76" modified="2013-07-24" version="1">MQAVRYHEHGDASVLQVDEVSDPSPDADEVVLSVAAAGVNPVDTYFREGSYEPFTLPMIPGVDAAGVVESVGDDVDGFDVGDRAIATGLGSAHLGGYAERVAVPTDRVAHLSDGVDLVEAGAAGVAAVTAWRALIDHAGLQPTEHCLIHGGSGGVGHAAVQIAKAAGATVVTTAAPRYHARLESLGSDVVLDYDRTDLADAVRDASDGGVDVTLDHRLDDYLQFDADVAAHEGRVVGIGENDPVVGFENDSPARGKDLRFQFMSMFNTPRLAEPLERVATLLDDGALSVEVEQTYSLENAAAAQTSVMTDSFLGKLAITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVZ5</accession>
    <name>R4VVZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02425"/>
    <dbReference type="EnsemblBacteria" id="AGN00436">
        <property type="protein sequence ID" value="AGN00436"/>
        <property type="gene ID" value="L593_02425"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02425"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131305_2_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14465" checksum="376768187E7C8291" modified="2013-07-24" version="1">MRDDERASALGDLEMGSSSSSRISDDRIFRALASKQRRRLLSYLLDGEVRTVEELATALTGWQASESGSMQTAADREQVRIELFHSHLPLLDEVGLIAYDRDRDVVRIESLDPVVEELLAGRFSTESPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW80</accession>
    <name>R4VW80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07675"/>
    <dbReference type="EnsemblBacteria" id="AGN01480">
        <property type="protein sequence ID" value="AGN01480"/>
        <property type="gene ID" value="L593_07675"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07675"/>
    <dbReference type="eggNOG" id="arCOG09017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3057007_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="54" mass="5805" checksum="DD818916201E79F9" modified="2013-07-24" version="1">MARCAEADCDRPAAVRVHVPWAEDRDVCAAHARTIASKDGVVAAPLEDAEDEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWA5</accession>
    <name>R4VWA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fused rhodanese domain-containing protein/hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445450.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03025"/>
    <dbReference type="EnsemblBacteria" id="AGN00556">
        <property type="protein sequence ID" value="AGN00556"/>
        <property type="gene ID" value="L593_03025"/>
    </dbReference>
    <dbReference type="GeneID" id="16180275"/>
    <dbReference type="KEGG" id="sali:L593_03025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.613"/>
    <dbReference type="eggNOG" id="arCOG00517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_2_2"/>
    <dbReference type="OrthoDB" id="25677at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="397" mass="43120" checksum="CCF26F9AFDEA493A" modified="2013-07-24" version="1">MNADDFPTPDVAVESVEPAQLKERVDAGEDLTILDARMTSDYEEWRIDGENVESINVPYFEFLEDEIDEDVFEQLPEDEEIVALCAKGGASEYVAGRLIEEGYDVVHLEDGMNGWARIYESVEVSDYDGAGTLYQYQRPSSGCLGYLLVEGDEAAVIDPLRAFTDRYLDDAENYSAELQYAIDTHIHADHISGVRDLDAAGVEGVIPAAAVDRGVTYADDLTLADDGDEFTVGDATIETVYTPGHTTGMTSYLVDDSLLATGDGLFIESVARPDLEEGDDGAPDAARMLYESLQERVLTLPDETLVGGAHFSDAAVPADDDTYTAPIGDLKERMDALSMEEADFVELILSDMPPRPANYEDIIATNLGQNAVDDEEAFTLELGPNNCAASQESLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWE0</accession>
    <name>R4VWE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446449.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01555">
        <property type="protein sequence ID" value="AGN01555"/>
        <property type="gene ID" value="L593_08050"/>
    </dbReference>
    <dbReference type="GeneID" id="16182294"/>
    <dbReference type="KEGG" id="sali:L593_08050"/>
    <dbReference type="HOGENOM" id="CLU_1870828_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="13784" checksum="3E7FF0985B7680C4" modified="2013-07-24" version="1">MASDTDGPADLVTHNDGSWIHRGKASGAINFAAVVLGSFGSLAVLNAVLQVATGGGVVVFELAPVAMAALSVGAGALGLVAAAGLFDVRPRSYWLGLAAFACYFVLGGIVNYVIAVVLAFLVVPLVVQRPAFREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWE9</accession>
    <name>R4VWE9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cdc6</name>
        <name evidence="6" type="ORF">L593_08100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446459.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08100"/>
    <dbReference type="EnsemblBacteria" id="AGN01565">
        <property type="protein sequence ID" value="AGN01565"/>
        <property type="gene ID" value="L593_08100"/>
    </dbReference>
    <dbReference type="GeneID" id="16182304"/>
    <dbReference type="KEGG" id="sali:L593_08100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1660"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_0_2"/>
    <dbReference type="OrthoDB" id="93705at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="54"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="376" mass="42073" checksum="3593492DED32DC08" modified="2013-07-24" version="1">MDGDPEEGMLAWDETVFRDERVFEIDYVPETFAHRESELENLKYALRPAVRGARPLNALVRGPPGTGKTTAIHKLFGELGAAADVSTVRVNCQVNDTRYAVFSRLFEHVFDYEPPASGVSFKKLFRQITERLVENEEILVVALDDVNYLFYENEASDTLYSMLRAHEEQGGAKIGVFVVSSDPDLDVIDELDGRVQSVFRPEKVYFPTYGQAELVDILGERVERGFNEGVVGPDVLDRVADLTAQSGDVRVGLDLLRRAGLNAEMRGSREVILEDVQEAFEAAKYVHLTHSLRTLSDSEAELVEVLAEHDGEQAGAVYEAFHDATDLGYTRYSEIVNKLDELGIVEAEYADLEGRGRSRELTLAYDADAVLDRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWH3</accession>
    <name>R4VWH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08250"/>
    <dbReference type="EnsemblBacteria" id="AGN01595">
        <property type="protein sequence ID" value="AGN01595"/>
        <property type="gene ID" value="L593_08250"/>
    </dbReference>
    <dbReference type="GeneID" id="16182347"/>
    <dbReference type="KEGG" id="sali:L593_08250"/>
    <dbReference type="eggNOG" id="arCOG04051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174522_0_0_2"/>
    <dbReference type="OrthoDB" id="119555at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="97" mass="10321" checksum="AD2051BF765BC32D" modified="2013-07-24" version="1">MICNERSTKEGLLVAICDDDVLGESFEEGEISLTVTEEFYGDEAVPAEAALASLRRATVANLVGERAVGMAIEAGIVEEQNVLEVGGTRHAQVLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWJ9</accession>
    <name>R4VWJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445550.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03525"/>
    <dbReference type="EnsemblBacteria" id="AGN00656">
        <property type="protein sequence ID" value="AGN00656"/>
        <property type="gene ID" value="L593_03525"/>
    </dbReference>
    <dbReference type="GeneID" id="16180581"/>
    <dbReference type="KEGG" id="sali:L593_03525"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.715"/>
    <dbReference type="eggNOG" id="arCOG00696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_2"/>
    <dbReference type="OrthoDB" id="44408at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="406" mass="43157" checksum="5E97DD02A1EED7A5" modified="2013-07-24" version="1">MRVIDADLLVTGRDAPPIEDGRIVIDEEDGTIDEVGTQEDVSATGDAAHEAHPVVTPGLIDAHLHLTGARSMDPMQWVIESSELGAARATADLRDLLAAGFTSVRDVGSQTGLGLRDAVAEGSIPGPRIYTSAQSISQTAGHGDSHFLPYEWVSGGERGIGTLADGPDECRKEARKRIRDGVDVLKIMTTGGVLSEKDAPDQSQFTDAEVQAFVEEAHRVGIPVASHAQGAPGIKTALRNGVDTIEHGFYLDEECLDLFEETGATFVPTLAIMYRLIEHGADHGVPEYGLEKSREASESHFDAVERAYDAGIPIATGTDFLGPELVPHGENALELELLADEVGMDEHDVLQSATRIAARTVPDDDVGTLEAGNRADVLALGSDPLEDISAVRDVEAVWTDGAAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWM7</accession>
    <name>R4VWM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP:cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_08500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446539.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08500"/>
    <dbReference type="EnsemblBacteria" id="AGN01645">
        <property type="protein sequence ID" value="AGN01645"/>
        <property type="gene ID" value="L593_08500"/>
    </dbReference>
    <dbReference type="GeneID" id="16182436"/>
    <dbReference type="KEGG" id="sali:L593_08500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1740"/>
    <dbReference type="eggNOG" id="arCOG00489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_2"/>
    <dbReference type="OrthoDB" id="98914at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="19818" checksum="3289F98C0651AA0F" modified="2013-07-24" version="1">MKIYTGRGDEGMTDLRDMSRVSKTSPRIEAYGTVDELNAVVGTVRPSAFEDVEEALAAVQNHLHVVQADFANPDPDEDDPIVREEHADELEAWIDEFQEELEPLESFILPGGSEEGAKLHQARAVSRRAERRAVDFASKEGANEAAMVYLNRLSDLLFVMARLVNQREGVEEENPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWU7</accession>
    <name>R4VWU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445615.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03850"/>
    <dbReference type="EnsemblBacteria" id="AGN00721">
        <property type="protein sequence ID" value="AGN00721"/>
        <property type="gene ID" value="L593_03850"/>
    </dbReference>
    <dbReference type="GeneID" id="16181366"/>
    <dbReference type="KEGG" id="sali:L593_03850"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.781"/>
    <dbReference type="eggNOG" id="arCOG01554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_6_0_2"/>
    <dbReference type="OrthoDB" id="54259at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="235" mass="25999" checksum="3D8BDD665F46E26B" modified="2013-07-24" version="1">MSSDEPRTAISGSTAPVTDTREARMGEGVDDRFNSKLREAFGSSPFILTKFDKFMNWARGSSMFLLQFGIACCSIEMMHTFAVKHDSDRFGAGVPRASPRQADVIIVPGTIVSKFAPRMKRVYDQMPEPKFVIGMGSCTISGGPFQEGYNVIKGAEEVIPVDIHVPGCPPRPEALLYGIAKLQERVANGESSPVVVKPYELQQFSEMEQDEVVEHLANEIDEDDLAMRYNWADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX22</accession>
    <name>R4VX22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbamoyl-phosphate synthase L chain ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446659.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN01765">
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        <property type="gene ID" value="L593_09100"/>
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    <dbReference type="KEGG" id="sali:L593_09100"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1866"/>
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    <dbReference type="HOGENOM" id="CLU_000395_3_1_2"/>
    <dbReference type="OrthoDB" id="36803at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="BC-like_N"/>
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        <property type="entry name" value="Biotin_BS"/>
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        <property type="entry name" value="Biotin_carboxylation_dom"/>
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        <property type="entry name" value="Biotin_COase_C"/>
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    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
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    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Biotin_lipoyl"/>
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    </dbReference>
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        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="610" mass="66172" checksum="3F88E6B1A1C7D636" modified="2013-07-24" version="1">MFRKVLVANRGEIAVRVMRACEELNVSTVAIYSEADKDGGHVRYADEAYNVGPATASESYLDHDAVIEAARKADADAIHPGYGFLAENAAFARKVEETDGITWVGPSGDSMESLGEKTKARTIMADADVPIVPGTKDPVTEVEEVTAFGEEHGYPIAIKAEGGGGGMGMQIVESAEEAEEQLKTAKREGEAYFDNDSVYLERYLENPRHVEVQILADEHGNVRHLGERDCSLQRRHQKVIEEGPSPALSDELREKIGESARRGVDAADYTNAGTVEFLVEEDTERDPDDLLGPDTNFYFLEVNTRIQVEHTVTEELTDIDIVKWQLKVADGQEITFEQDDVELEGHAMEFRINAENAANQFQPVGGGHLETYDPPGGIGVRMDDALRQGDDLPGDYDSMIAKLIVHGSDRDECIARSLRALREYEIEGITTIIPFHRLMMADEAFIDGKHTTKYLDEELDHARIEEAQAQWGPEDGAGDAGDDEETVTREFTVEVNGKRFEVDLEEKGAPPITADSAGSGGAQRPDHVGGDSGGGGAVGEGESIAAEMQGTILEVNVAEGDEVASGDVVCVLEAMKMENDVVADQGGTVSEVRVGEGDSVDMGDVLIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX38</accession>
    <name>R4VX38_9EURY</name>
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        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Epimerase_deHydtase"/>
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    <dbReference type="InterPro" id="IPR001995">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="332" mass="35283" checksum="30D4040DB37C9A4B" modified="2013-07-24" version="1">MSDASPGSDRRPGVLPDGGHIVSFPDGDAVVTGGAGFLGSHLVERLLDDGADVTVVDDLRGGNREWVPDAAALQEFDLAAPGAVDDLVAVLPTGADVYHLAADKYVDNDEPIEQYARNTRMTQHVVAAAEAADAERFVFTSSSTVYGEAPRPTPEDYAPLEPISAYGAGKLADEGLLSARAHAGAFDAWTFRFANVVGPRLRGAVVPDFIEKLQADPSTLEILGDGRQEKSYLTVGDCLDGMAHAVARANDPVNTFNLGTRTTTSVDRIAAIVAEELGVDPAYSYTGGERGWKGDVPKMCLSVEKLSALGWEPTRSSDDAIRRATRQLIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXE3</accession>
    <name>R4VXE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-sulfoquinovose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445825.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04910"/>
    <dbReference type="EnsemblBacteria" id="AGN00931">
        <property type="protein sequence ID" value="AGN00931"/>
        <property type="gene ID" value="L593_04910"/>
    </dbReference>
    <dbReference type="GeneID" id="16180174"/>
    <dbReference type="KEGG" id="sali:L593_04910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1003"/>
    <dbReference type="eggNOG" id="arCOG04762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040971_1_0_2"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="43328" checksum="0994749A270AA994" modified="2013-07-24" version="1">MSVIVTGADGYLGWPTALRIADRTDERVVLVDNGGRREWVESVGSTSAVPIASMEDRLAAAEEELGLANLSYVEADLTDRAAIDQLLSVHEPDTIVHAAAQPSAPYSQINGERANFTQHNNMQATRNLVWGLEEAGMTDTHLIETTTTGVYGAPEFPIPEGGAVMENDGDRDDVPFPAMAGSWYHLTKSHDAANLRLAHDQFGIPISDVRTAITYGTGTEETEAHPDLATRFDFDYYFGVVAHRFCAQAVAGYPMTVYGKGEQRKPFIALEDAVEGLARLAVGADADDDPAERPDDHVVYNQVTRAISIVEVAQTIADVSGEFDLDVAVEHFENPRDEDETHKMEIENDRYADLIGGQSTDYEEGVRQILGDLVEYQDTVAAHEDRFLPGVLTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXI5</accession>
    <name>R4VXI5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445865.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05110"/>
    <dbReference type="EnsemblBacteria" id="AGN00971">
        <property type="protein sequence ID" value="AGN00971"/>
        <property type="gene ID" value="L593_05110"/>
    </dbReference>
    <dbReference type="GeneID" id="16181211"/>
    <dbReference type="KEGG" id="sali:L593_05110"/>
    <dbReference type="eggNOG" id="arCOG04606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194234_0_0_2"/>
    <dbReference type="OrthoDB" id="126692at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="80" mass="8599" checksum="30F33A426131A798" modified="2013-07-24" version="1">MELQQFINDDDRSVHSVRRDGGQTVVADFGPGAGDASVDVVGDTAIVMHGEEQTDIDLPEPVARAFMENGVLTIELEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXQ6</accession>
    <name>R4VXQ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L593_10500</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446939.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10500"/>
    <dbReference type="EnsemblBacteria" id="AGN02045">
        <property type="protein sequence ID" value="AGN02045"/>
        <property type="gene ID" value="L593_10500"/>
    </dbReference>
    <dbReference type="GeneID" id="16182483"/>
    <dbReference type="KEGG" id="sali:L593_10500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2164"/>
    <dbReference type="eggNOG" id="arCOG01113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_2"/>
    <dbReference type="OrthoDB" id="3139at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="150"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="247"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="14">
        <location>
            <begin position="460"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AGN02045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="575" mass="61279" checksum="BEFB023871D4A044" modified="2013-07-24" version="1">MTRTFEGVGATPLSGVGTARWSDPPLPEFEHESDDPERERERFEDARDAARAAIQTERERAAEHLGEEEAGILDAHRQFLDDPQIESSVETAIEAGHTAEAAVETAFDDPIEQYEESGGRLAERADDLRDVRDRLLRTLADVDAVDLSALPEGTVLLAERLAPSDAARLDPDRVAGLATVVGGRTAHAAIVARALGIPAVVGVGDDLREVEDGEQLVVDGDVGTVVVDADEATLTAAKRGREVDVIAEPVETADGHPIEVAANVGRPVELEGAVANGADGVGLYRTEFLYVDRSTPPDEDEQFEAYRNALDAFPDRRIVIRTADVGGDKPIPYLDLPEEPNPFLGVRGVRRSLGPDGDLFETQLRALLRAAGDAAAGDGSPNDAASDESTGALAVMFPMVTELRELEAVLERIAAVEDDLGDAGEPVARPELGVMIETPAAVRMAPELAEHLDFLSIGTNDLTQYVMAADRDNEQVASLHDPLHPPVVRAIRATIEGGHENDAWVGMCGEMAGDPSVTELLLGLGLDEFSASAVTIPQVKAKVQQTTLEDAEALAERVLDAATREEVQAILDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY13</accession>
    <name>R4VY13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_11050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02155">
        <property type="protein sequence ID" value="AGN02155"/>
        <property type="gene ID" value="L593_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_11050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2279"/>
    <dbReference type="eggNOG" id="arCOG06410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3147874_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="48" mass="5996" checksum="DFEA549FBFAF6C52" modified="2013-07-24" version="1">MRSEDEVREQYEYLAEQLEDEDMRHEGVRELFTHYKRALGWVLEEEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYI8</accession>
    <name>R4VYI8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="5" type="ORF">L593_11910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447219.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11910"/>
    <dbReference type="EnsemblBacteria" id="AGN02325">
        <property type="protein sequence ID" value="AGN02325"/>
        <property type="gene ID" value="L593_11910"/>
    </dbReference>
    <dbReference type="GeneID" id="16182250"/>
    <dbReference type="KEGG" id="sali:L593_11910"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2451"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OrthoDB" id="73593at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="4">
        <location>
            <begin position="114"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="353" mass="37280" checksum="7167F8DF0092B045" modified="2013-07-24" version="1">MSAEHRTETIPEWKREEVDAIVDMLDQYDSVGVVDITGIPSKQLQDMRRGLHGTAALRVSRNTLLRRALEESDRGLDQLTEFVTGQVGLITTNENPFGLYQQLEESKTPAPIGAGEVAPNDIVIEEQDTGIDPGPFVGDLQTVGAAARIMEGSIHVTEDSTVAEAGDEVSDDLANVLGELGLEPKEVGLDLRGVVADGVLFEPEELEIDVDEYRDDVATAAARARNLSVNATYPTATTAGTLIAKAQGEAKSLGLQASIESPSLADDLVSKADAQVRALVAQVDDPEALPEDLQDVEAPAQPAAEEAAEADEAGDDEADDEQADDQADAEADDEDDGDDDGDAAAEGLGDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ53</accession>
    <name>R4VZ53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07930"/>
    <dbReference type="EnsemblBacteria" id="AGN01531">
        <property type="protein sequence ID" value="AGN01531"/>
        <property type="gene ID" value="L593_07930"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07930"/>
    <dbReference type="HOGENOM" id="CLU_2679093_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="8182" checksum="CC99493705BD532A" modified="2013-07-24" version="1">MTPVKHHAMPSVPQSRQFAYAVSSTLVPFVAWVQWFQSSDGALVLWAAVGLFVLAVALDWTLQRQLRADRDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZC8</accession>
    <name>R4VZC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446505.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08330"/>
    <dbReference type="EnsemblBacteria" id="AGN01611">
        <property type="protein sequence ID" value="AGN01611"/>
        <property type="gene ID" value="L593_08330"/>
    </dbReference>
    <dbReference type="GeneID" id="16182367"/>
    <dbReference type="KEGG" id="sali:L593_08330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1707"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="15834" checksum="6941DA7599AFE3D4" modified="2013-07-24" version="1">MYDDVLIPTDGSDAVDAALRHGLRIAENEGATVHGLYVVDKRITDAADPETRPDVEATLTDEGGAALEALSAAAERKGLPVVTEQRHGTPYKEILDYADEEAVDLVAIGSHGKSPREKLTSLGSVSERVVDGASIPVLVVRSEDAASADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W036</accession>
    <name>R4W036_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lycopene cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L593_09480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446735.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09480"/>
    <dbReference type="EnsemblBacteria" id="AGN01841">
        <property type="protein sequence ID" value="AGN01841"/>
        <property type="gene ID" value="L593_09480"/>
    </dbReference>
    <dbReference type="GeneID" id="16180068"/>
    <dbReference type="KEGG" id="sali:L593_09480"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1952"/>
    <dbReference type="eggNOG" id="arCOG09070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163809_0_0_2"/>
    <dbReference type="OrthoDB" id="121280at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="10">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13211" checksum="B878422637DF54B1" modified="2013-07-24" version="1">MPHAGPLPDITVLGDYTYLATEVVFGAAAIALLYRADAFRRAGLTVLALYPIAYLWDWYTLHVGVFSIEARTGIEFLWIPIEEHIFMLVVPALVIGVHETLHGDGGPVDSGGGTGDGAVTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0F1</accession>
    <name>R4W0F1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase</fullName>
            <shortName evidence="1">GCS</shortName>
            <shortName evidence="1">Gamma-GCS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gshA</name>
        <name evidence="2" type="ORF">L593_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446875.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10180"/>
    <dbReference type="EnsemblBacteria" id="AGN01981">
        <property type="protein sequence ID" value="AGN01981"/>
        <property type="gene ID" value="L593_10180"/>
    </dbReference>
    <dbReference type="GeneID" id="16180290"/>
    <dbReference type="KEGG" id="sali:L593_10180"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2098"/>
    <dbReference type="eggNOG" id="arCOG02722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_1_0_2"/>
    <dbReference type="OrthoDB" id="39298at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="359" mass="40232" checksum="B092293B3993A86D" modified="2013-07-24" version="1">MDRGSADVFTELGTIGIEEEFYVVDDAGRPTAGTDELVYETEPPEILEDRLDHELFKCVIETQTPTIDRLDDAAGILDDVRDALVEHASANGFQIAAAGLHPTAKWRELEHADKPRYRAQLDRIQYPQHRNTTAGLHVHVGVDDADKATWIANELRWYCPVILALSANSPFWCGFDTGLHSARAKIFEALPNTGIPTQFADFDDYLTFENRMIDSDAIEDRGELWYDVRPHSAHGTVEVRSPDGQADPARVMAFVEYVHALVLDLADRYEDGEDGTAYRREALDENKWRAIRYGQDASFLQPDGTTVPLGEVVEREADRLDVDGIRDIYETESGAARQRRLQSDADVDALCESLLLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0L0</accession>
    <name>R4W0L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446965.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10630"/>
    <dbReference type="EnsemblBacteria" id="AGN02071">
        <property type="protein sequence ID" value="AGN02071"/>
        <property type="gene ID" value="L593_10630"/>
    </dbReference>
    <dbReference type="GeneID" id="16180055"/>
    <dbReference type="KEGG" id="sali:L593_10630"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2192"/>
    <dbReference type="eggNOG" id="arCOG00386">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485937_0_0_2"/>
    <dbReference type="OrthoDB" id="85622at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="197" mass="20728" checksum="F3719084A9CB5AD5" modified="2013-07-24" version="1">MDRPALHGKRLLAAAVFVAATLVLAVQLINPSPVVVSVGENGAQTDELGQYFTYSDVGTIAGAALLVGATGTYILTGPTAARSEPSARQSGSTDSRGVTAPATPADGVVEDGGSTAATFSVEQQEREEWETAHEGLYGNEKTVYGVVLDADGKLPQRDIVERTDLSKATVSRTLDTLESKRLVERKRRGMGNVVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W123</accession>
    <name>R4W123_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447145.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11540"/>
    <dbReference type="EnsemblBacteria" id="AGN02251">
        <property type="protein sequence ID" value="AGN02251"/>
        <property type="gene ID" value="L593_11540"/>
    </dbReference>
    <dbReference type="GeneID" id="16180964"/>
    <dbReference type="KEGG" id="sali:L593_11540"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2379"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_3_0_2"/>
    <dbReference type="OrthoDB" id="85871at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="227" mass="24512" checksum="8CC0261B7F3EFE89" modified="2013-07-24" version="1">MLSCELHTHSKLSHDGRDPVDLLVEQADAVGLDALAVTDHDEIEASLEAAELAEERGMVGIPGIEVTSRAGHILGLGVDEQIQPGLPYENTLNLIRDAGGIAVIPHPFQEARHGVMANITLDQLAMADAIEVYNSRLLTGRANRQAKRFAQENGLPMVAGSDAHISEMVGQARTLIDATERSVPSILDAIRAGGTEIDGKRTPWRISFRQLAGGVSRRIQRRLAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W194</accession>
    <name>R4W194_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447240.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12015"/>
    <dbReference type="EnsemblBacteria" id="AGN02346">
        <property type="protein sequence ID" value="AGN02346"/>
        <property type="gene ID" value="L593_12015"/>
    </dbReference>
    <dbReference type="GeneID" id="16180062"/>
    <dbReference type="KEGG" id="sali:L593_12015"/>
    <dbReference type="eggNOG" id="arCOG04721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132452_0_0_2"/>
    <dbReference type="OrthoDB" id="100782at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="146" mass="15605" checksum="0A455654FB6FDA12" modified="2013-07-24" version="1">MSVGGARSPVVRVATTADHVAVSRVLDGALLEVDGLRTRLEDGTVLVATLEGTSDAVVGTLVVAPEGPTNLDPPADWPDAAHLRAIAVRRKRRRSGIGTALLDAARERWSPLVADFDADVEPFYEALGAECQETPDGRRWALLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1A5</accession>
    <name>R4W1A5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447255.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12090"/>
    <dbReference type="EnsemblBacteria" id="AGN02361">
        <property type="protein sequence ID" value="AGN02361"/>
        <property type="gene ID" value="L593_12090"/>
    </dbReference>
    <dbReference type="GeneID" id="16179824"/>
    <dbReference type="KEGG" id="sali:L593_12090"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2488"/>
    <dbReference type="eggNOG" id="arCOG08109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945324_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="285" mass="30314" checksum="44AAE4ADBE3605FE" modified="2013-07-24" version="1">MVNLVLAGAASLLAAVIAPPLAAAVFAVSVLVIYFRGYLVPGTPELTKRYLPDSVLARFDHAESHPAESGGTGVRGDETGTGAGADDASDGDEPEFEAIQKLEEQRANEVDPETFLQDNGVIEPGPSDDPVLTDAFTERVARHLEGLAVDDLDDGLATLFEVEPAELEHVDRDYPAIKIDARIRQWPSEAALLADVAAHEALLASDADWLDVPLEQRLNLLESLRSFRQACPACGGSVVGNESVVQSCCRSFDVVTMACEDCEARILELPAHAADGIDTPGGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1W7</accession>
    <name>R4W1W7_9EURY</name>
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        <submittedName>
            <fullName evidence="8">Type II secretion system F domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_13585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447550.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13585"/>
    <dbReference type="EnsemblBacteria" id="AGN02656">
        <property type="protein sequence ID" value="AGN02656"/>
        <property type="gene ID" value="L593_13585"/>
    </dbReference>
    <dbReference type="GeneID" id="16180710"/>
    <dbReference type="KEGG" id="sali:L593_13585"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2781"/>
    <dbReference type="eggNOG" id="arCOG01808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017646_1_0_2"/>
    <dbReference type="OrthoDB" id="7960at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="163"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="474"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="684" mass="74969" checksum="C779D3DB8A447D5E" modified="2013-07-24" version="1">MSLDTLGESGQGTTVSGADSLGDAFYPLYEWLFSEDSEFVSDLETKLAQARMPDTVELYLSRALAIGAITGVSLWIVGTVLGYVLFATGVIDLGSAVIVQNVSPGVADVLKMLRVPLLVLVTGLMFGSVGFAMGFGVLVAVPYSRASTRKREINMLLPDAVSFMYALSVGGLNQLEILQAMAEADDTYGEVSREFKSIVQETQYFDTDYRTAIRNQALTTPSDELAQFLTDMLSIVSSGGNMEAFLDDKKDKHMRTAKQQQEMTLETLELFGEMYMTLSLFPLLLIIILVIMMMIGEAQAMMIYATVYALVPMTGLGFLVLVSTVKQDEVGDGYLMPSGGSDRLRVQQQSGLLNLGIVESFTGEYSVFDRIKNREGSYEATQIIKRPHVFFRDNPLYTLAITVPLALVIVGVAVGTGSAPTAWKGAGGMIESPIWGTFLYIYLPAYIVLVPLTIFYEWNTRSRYGVTNNLSDNLRKLSSANDTGLTLLESFYTVADTTSGKLATEFRTMHAKVNYGMSLREALVEFNNKYHIPRLSRTVKLISKAQEASSQITDVLRTAATASENQDDIDRERKSRTRMQVVIIMMTFLTLLAVMAILQTQFLETMAELTSGSEEESASTAGAGFNLGAVNPNELSLLFFHAVTMQAILSGFISGYMRDADILSGVKYVVVLLTIALGVWMFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1X4</accession>
    <name>R4W1X4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="5" type="ORF">L593_13635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447560.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13635"/>
    <dbReference type="EnsemblBacteria" id="AGN02666">
        <property type="protein sequence ID" value="AGN02666"/>
        <property type="gene ID" value="L593_13635"/>
    </dbReference>
    <dbReference type="GeneID" id="16179915"/>
    <dbReference type="KEGG" id="sali:L593_13635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2790"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OrthoDB" id="96138at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_S3Ae_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="211" mass="23875" checksum="26D1A11EC41F7424" modified="2013-07-24" version="1">MSERSVSRQRQEKRWYTVHAPEQFDRAELGETPADEPDQVLGRTVETTLGDLQDDAGENNTKLTFKINDVGSDAAYTEFIEHELTRDYLRSLVRRGASKVEAYVTVLTTDDYRVQIQPVAFTTKKADASQEKAIRRVMIDMIEEAGEERTFEALIDSIVEGRLSSAIYGEAKSIYPLRRVEIQKATLEARPEEVAAEEEAAVDVDDEDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1Z5</accession>
    <name>R4W1Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-P-glucose transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447580.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13735"/>
    <dbReference type="EnsemblBacteria" id="AGN02686">
        <property type="protein sequence ID" value="AGN02686"/>
        <property type="gene ID" value="L593_13735"/>
    </dbReference>
    <dbReference type="GeneID" id="16181049"/>
    <dbReference type="KEGG" id="sali:L593_13735"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2809"/>
    <dbReference type="eggNOG" id="arCOG00895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_2"/>
    <dbReference type="OrthoDB" id="17570at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="247" mass="26694" checksum="3D17EDA360E65606" modified="2013-07-24" version="1">MQSSLGIVVPAYDPDVERMASYVDSLEQRLDPATIRIELDDPSGRVRERIPDDLPATVAVSATRRGKGAAITAGFEALDTDLYCFVDADGSTDVESVERVIDQVRSGGCDLAVGSRRHPEATVSNTQSQLRGTLGDGFAWIARLLLPVALFDYQCGTKAMDADSWAIVRGDLYEPGFGWDVNLVAAAGYHSLTVAEVPVSWSDHPSSTVDPLSATLTLGGALWRTKRHRLLGSTGRRPLLEQLADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W252</accession>
    <name>R4W252_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="7">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">aIF2-gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">eIF-2-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eif2g</name>
        <name evidence="9" type="ORF">L593_13885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447610.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13885"/>
    <dbReference type="EnsemblBacteria" id="AGN02716">
        <property type="protein sequence ID" value="AGN02716"/>
        <property type="gene ID" value="L593_13885"/>
    </dbReference>
    <dbReference type="GeneID" id="16180894"/>
    <dbReference type="KEGG" id="sali:L593_13885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2841"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OrthoDB" id="25592at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00119">
        <property type="entry name" value="eIF_2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="43884" checksum="E6D30476EEE130A9" modified="2013-07-24" version="1">MAGSNRHPEVNIGLVGHVDHGKTTLVQALSGEWTDQHSEEMKRGISIRLGYADTTFRKCPEEDGTQAYTVAEECPEHEVETDVLRTVSFVDAPGHETLMATMLSGAAIMDGAVLVVSATEDVPQPQTEEHLMALDIMGLDNLVIAQNKIDLVDREQAVANNEAIEEFVEGTVAEGAPIVPVSAQQGVNMDLLIEAIEDQIPTPERDPDADPRMQVARSFDINRPGTTWEDLLGGVLGGSLVEGTLSVDDEIEIRPGREVEEGGETRYDPISTTVRSIQAGGTPTDEATPGGLLGIGTGLDPSLTKGDALAGQVAGHEGSLPPTWEQFTMSVDLLDRVVGDMDEEEVDEITTGEPLMMTVGTATTVGSVTSARGDEAEVALQRPVCAQEGATIAINRRVGSRWRLIGIGTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2C8</accession>
    <name>R4W2C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447720.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02826">
        <property type="protein sequence ID" value="AGN02826"/>
        <property type="gene ID" value="L593_14435"/>
    </dbReference>
    <dbReference type="GeneID" id="16181255"/>
    <dbReference type="KEGG" id="sali:L593_14435"/>
    <dbReference type="HOGENOM" id="CLU_1335102_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="205" mass="23659" checksum="10416866090082E8" modified="2013-07-24" version="1">MADDINQLLPEESDIIIWNVENLPNHHVAIDSGDLATVIEKAVSAGASEIYHCTEPEAGYPGIAWRVNDLTHVYHTGDYVEPELPEDEIEDSQSDEDRRIDELADEILDNYRELLGDDEIYRFEENREILRVENLLRKREEIEEEARADPETEKAAAEWLAEHEKFNLNSSTVDAELLIEESEFDMDEVRVEPVRKRARAILNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2D0</accession>
    <name>R4W2D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_14460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447725.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14460"/>
    <dbReference type="EnsemblBacteria" id="AGN02831">
        <property type="protein sequence ID" value="AGN02831"/>
        <property type="gene ID" value="L593_14460"/>
    </dbReference>
    <dbReference type="GeneID" id="16180977"/>
    <dbReference type="KEGG" id="sali:L593_14460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2957"/>
    <dbReference type="eggNOG" id="arCOG02353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="138"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN02831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="347" mass="38806" checksum="92B9318DDE89C7C2" modified="2013-07-24" version="1">MPAEALSEDENFRTLLDHLEGVAIWIISEPPEFEYVSAGIEDIWGVPAAELESSVLRMIEYIHEDDQEQLLELLDSPDAELEEMTVQHRVVRPDDEVRWVQGRLFPIEEQGVVKVVGASTDITEQKRRERQLEALNRVVRHDIRNDMAIMLGWAEMLDEHLDPAGREHLEKILTSGDHVVELTKIARDYIETLTSDEELPVSATALQPVLEREVTLCRQSYPDAEVAVGDVPDVEVTGNAMLQSVFRNLLNNAVQHNDRATPSVEVTAVEHEETVAIAIADDGPGIPDQLRSSLFDKGWKDVGSQGSGIGLYLVDLLVDQFGGDVRVEDRDPRGTIFTVELPLAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2G3</accession>
    <name>R4W2G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444851.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGM99956">
        <property type="protein sequence ID" value="AGM99956"/>
        <property type="gene ID" value="L593_00010"/>
    </dbReference>
    <dbReference type="GeneID" id="16180701"/>
    <dbReference type="KEGG" id="sali:L593_00010"/>
    <dbReference type="eggNOG" id="arCOG03916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159082_0_0_2"/>
    <dbReference type="OrthoDB" id="123514at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGM99956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="104" mass="11485" checksum="2AA284887D297FE0" modified="2013-07-24" version="1">MIYGFTNLRLVILAASLVATLLGLVVGYQAYRGFRRHQSASMRQLSVGLLLLTAVSFTLAFVGTLLLRAEYLDPSLRDPLTLVVRLLQVAGLALITYSLYNRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2P5</accession>
    <name>R4W2P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PQQ enzyme repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00560"/>
    <dbReference type="EnsemblBacteria" id="AGN00067">
        <property type="protein sequence ID" value="AGN00067"/>
        <property type="gene ID" value="L593_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00560"/>
    <dbReference type="eggNOG" id="arCOG02492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027480_4_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="456" mass="47681" checksum="5DEDBD0F0CA33BFA" modified="2013-07-24" version="1">MAGAALVFGLAGCSTTGDNSNSADDSATGHNGSRSSRDGTGDNETEYNSGTGDGGSDSGSNETDSDPQGDDDSGSQNEIGSASGSWQTYQYDTARSGYAPSETPPGDDASVQWTSEVGQTFAESSPAVSGETVVVTTYGGSVRGIDLATGTERWVYETSQDVYASPTVQNGTAFVGAADGKLHAIDTSTGEGRWTYTAGYPVNRSVAVSGDVYLAAQSGTNSAFVAALDPETGGERWRHSLDTYGEYGATVSGAVTVADESVVIGTGRYGSTFVCLDASTGDSVWTFDSSTYSGQSYDEVFHTAAVVDGSVFVPLTVEDPNNVSTIISFDLSTGDVRWEWQREGELVAGDCAVGPEAVYITTTSDDTAKLVRLNRQTHSVDWSVDLATSSPRCAPLLVDSTLFVGNSRFDPADGAHLGVVGESQSWAQRPITNGYLVQNHSSRRGSSYKMYSTDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2V8</accession>
    <name>R4W2V8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445081.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01170"/>
    <dbReference type="EnsemblBacteria" id="AGN00187">
        <property type="protein sequence ID" value="AGN00187"/>
        <property type="gene ID" value="L593_01170"/>
    </dbReference>
    <dbReference type="GeneID" id="16182841"/>
    <dbReference type="KEGG" id="sali:L593_01170"/>
    <dbReference type="eggNOG" id="arCOG08216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173007_1_0_2"/>
    <dbReference type="OrthoDB" id="123229at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="82" mass="9331" checksum="5C57175A5749E19F" modified="2013-07-24" version="1">MGVERSTDKRGRITIPTELRERFGDRYRVVELEDGIKLVPIPQNPIETLRESGSEELRETSADALRAVARSRGDAEVDEHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W308</accession>
    <name>R4W308_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445131.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00237">
        <property type="protein sequence ID" value="AGN00237"/>
        <property type="gene ID" value="L593_01420"/>
    </dbReference>
    <dbReference type="GeneID" id="16182851"/>
    <dbReference type="KEGG" id="sali:L593_01420"/>
    <dbReference type="eggNOG" id="arCOG06371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2821022_0_0_2"/>
    <dbReference type="OrthoDB" id="129402at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="66" mass="7513" checksum="BFFA84449F833A63" modified="2013-07-24" version="1">MATTDNSIDGMTEHCEACDMDTLHEVNVQIKTESTTSENAHYSREPYRVKECQQCGERSSQRMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W344</accession>
    <name>R4W344_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445196.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01755"/>
    <dbReference type="EnsemblBacteria" id="AGN00302">
        <property type="protein sequence ID" value="AGN00302"/>
        <property type="gene ID" value="L593_01755"/>
    </dbReference>
    <dbReference type="GeneID" id="16179930"/>
    <dbReference type="KEGG" id="sali:L593_01755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.355"/>
    <dbReference type="eggNOG" id="arCOG03143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117036_0_0_2"/>
    <dbReference type="OrthoDB" id="103543at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043852">
        <property type="entry name" value="DUF5814"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19131">
        <property type="entry name" value="DUF5814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="151" mass="16871" checksum="A77DD0C962E1081C" modified="2013-07-24" version="1">MAITDKIYVKNHRQLSSQLETSIPRGAFSGATLDLLFQGDGLEKLDEATREKVLDFAQDFLDCDCDSNPYCGCPEEKFLVYLLELREEGHSPEAIVDVMSAEYMVYAYSGDVLSFLDRAVRILEAVEDLAVVEGNDDARRRAAAAIRRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R4W363</accession>
    <name>R4W363_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ORF">L593_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445231.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01930"/>
    <dbReference type="EnsemblBacteria" id="AGN00337">
        <property type="protein sequence ID" value="AGN00337"/>
        <property type="gene ID" value="L593_01930"/>
    </dbReference>
    <dbReference type="GeneID" id="16179989"/>
    <dbReference type="KEGG" id="sali:L593_01930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.393"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OrthoDB" id="60670at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="214" mass="21192" checksum="4B3EA329F4739FD5" modified="2013-07-24" version="1">MFVLVNLKAYDCDPVAIGRAAAEVADDAGARIAVAPQAADLRAVAETGVETWAQHVSPVEHGSNTGSTLAESVAAAGAEGTLLNHSERRLKLADIDASIDAARRANLDVVACANNPEQVAAVAALEPDAVAVEPPELIGTGTPVSQADPDIVEGAVAAAADVDPAVEVYCGAGISTGDDVVAAGDLGAEGVLLASGVAKADDPAAALRDLVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3H7</accession>
    <name>R4W3H7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo12</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">rpoP</name>
        <name evidence="8" type="synonym">rpo12</name>
        <name evidence="9" type="ORF">L593_02930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445431.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02930"/>
    <dbReference type="EnsemblBacteria" id="AGN00537">
        <property type="protein sequence ID" value="AGN00537"/>
        <property type="gene ID" value="L593_02930"/>
    </dbReference>
    <dbReference type="GeneID" id="16180380"/>
    <dbReference type="KEGG" id="sali:L593_02930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.593"/>
    <dbReference type="eggNOG" id="arCOG04341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_2_1_2"/>
    <dbReference type="OrthoDB" id="129924at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00615">
        <property type="entry name" value="RNApol_arch_Rpo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023464">
        <property type="entry name" value="Rpo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="DNA_RNApol_7kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="45" mass="5191" checksum="980B4096CC986512" modified="2013-07-24" version="1">MSAYKCSRCKRDVSLDEYGGVRCPYCGHRVLLKERSPDVKEIDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3I5</accession>
    <name>R4W3I5_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">L593_03005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445446.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03005"/>
    <dbReference type="EnsemblBacteria" id="AGN00552">
        <property type="protein sequence ID" value="AGN00552"/>
        <property type="gene ID" value="L593_03005"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.609"/>
    <dbReference type="eggNOG" id="arCOG09681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_21_2_2"/>
    <dbReference type="OrthoDB" id="41839at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="259"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="546" mass="59809" checksum="0754C46F7FF2C3B7" modified="2013-07-24" version="1">MNPEEVFGRGGLNANVDADQLTDDIGLDRDEIAWRKEFIGFDAEDERRLASMEPLLREHREEIAERFYENLTQYEQTTDVIGRSEKSVEQLKQTQQAYMVTLATGEYDEAYFRNRARIGKLHELLDMPLKHYIGQYGVYYDLLFERLDDRIQNQVVAAIEDWAVERAEAERSDGLFGSVLGALGDDADDPGDLDEDFESTVRDAIHDGVADLLALLRIINLDVQVACDTYVDSYSNRLEAEIQRRQRLASEVETDVQEPIGDLHDAAGTVAEGAETIHELTTDQSQGVRTAAEEAEDLSATVEEIAGTAGNVRTLGERTEEVASEGVAEAEETVAAMDDLREETQAAVAATERLEQQADRIDDVVETIEEVTNQTKILAANARVEASRSDASSEALDVLGEEVRSFAEETSEQLQALPETVEELRGIAREVSDAIDAAAAQLEDSSEQVESLGERLDTVHGAADETADGMAEIEQATEQQARSAEAIAAEMDGLADAADRVASETESLAASAEEQTAALGDVAESVERLTDTSDLASNAEERRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3K9</accession>
    <name>R4W3K9_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445486.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03205"/>
    <dbReference type="EnsemblBacteria" id="AGN00592">
        <property type="protein sequence ID" value="AGN00592"/>
        <property type="gene ID" value="L593_03205"/>
    </dbReference>
    <dbReference type="GeneID" id="16180460"/>
    <dbReference type="KEGG" id="sali:L593_03205"/>
    <dbReference type="eggNOG" id="arCOG03027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151086_0_0_2"/>
    <dbReference type="OrthoDB" id="103746at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="2">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="115" mass="12596" checksum="A6D3F8049F95F732" modified="2013-07-24" version="1">MSEVRDEELAERVEEWLTRQMPIIQMHGGTSNVRKADPETGEVVIELGGGCAGCDVGDITSGNIEQELITWDEIEEVTVRVPESGESFGVDQEESIMGIDRTEGGRGDVKGSRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Y1</accession>
    <name>R4W3Y1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purM</name>
        <name evidence="10" type="ORF">L593_04205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445686.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04205"/>
    <dbReference type="EnsemblBacteria" id="AGN00792">
        <property type="protein sequence ID" value="AGN00792"/>
        <property type="gene ID" value="L593_04205"/>
    </dbReference>
    <dbReference type="GeneID" id="16180867"/>
    <dbReference type="KEGG" id="sali:L593_04205"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.855"/>
    <dbReference type="eggNOG" id="arCOG00639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_2"/>
    <dbReference type="OrthoDB" id="62508at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="8">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="9">
        <location>
            <begin position="181"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="345" mass="35907" checksum="5985B03E0D01C992" modified="2013-07-24" version="1">MTEDGDAGADGPDHPHGDEPDAEEGLTYSEAGVDIGESEAATAALLDAVGNVVDTEYAGMLEVGDQYLALATDGVGTKLMVAEAIEDYTTIGIDCVAMNVNDLVAAGVEPLAFVDYLAVDEPGETLANEIGQGLADAAEETGIALLGGETAVLPEVVTGFDLAGACVGMADQDAVFPGEAEPGDALVGVRSSGIHSNGLTLAREAATLDHEYTDPFPPDPDRTIGEVLLEPTALYSDLLEPMREHGVRAAAHVTGGGWTNLERMGEHRYEIEDAFDPQPVFEFVQDAGNVSEKEMYRTFNMGTGFVAALPAERADDLAEAVDGRVIGHVEAGSGVSIRDLELGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W451</accession>
    <name>R4W451_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445811.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04840"/>
    <dbReference type="EnsemblBacteria" id="AGN00917">
        <property type="protein sequence ID" value="AGN00917"/>
        <property type="gene ID" value="L593_04840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181114"/>
    <dbReference type="KEGG" id="sali:L593_04840"/>
    <dbReference type="eggNOG" id="arCOG04789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160437_0_0_2"/>
    <dbReference type="OrthoDB" id="116189at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="95" mass="10487" checksum="56B890ED1911AB87" modified="2013-07-24" version="1">MGELETEETRTRTEVATYLRDLAEQLDADAPVTLTLGDRQVDLDPTDPITFKLEGESDWSEGDTEAKQSIEFELVWRTAATTAAEGELDVEPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W482</accession>
    <name>R4W482_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05115"/>
    <dbReference type="EnsemblBacteria" id="AGN00972">
        <property type="protein sequence ID" value="AGN00972"/>
        <property type="gene ID" value="L593_05115"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05115"/>
    <dbReference type="HOGENOM" id="CLU_2679092_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="74" mass="8046" checksum="92C230DD3D03A467" modified="2013-07-24" version="1">MVFDRVGDGIRSDRRRSSIGSEIVFARYGDVESPGPFVRRHRTVPTPGGCSVRNPDEVTTSVPASTVSRGDRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4I5</accession>
    <name>R4W4I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_05990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446041.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05990"/>
    <dbReference type="EnsemblBacteria" id="AGN01147">
        <property type="protein sequence ID" value="AGN01147"/>
        <property type="gene ID" value="L593_05990"/>
    </dbReference>
    <dbReference type="GeneID" id="16181584"/>
    <dbReference type="KEGG" id="sali:L593_05990"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1227"/>
    <dbReference type="eggNOG" id="arCOG07337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_2"/>
    <dbReference type="OrthoDB" id="1952at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="207"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase_ig" evidence="11">
        <location>
            <begin position="686"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="10">
        <location>
            <begin position="778"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="854" mass="94411" checksum="51636DC3FE75D49B" modified="2013-07-24" version="1">MADQLTSTSLAGEWSVRQASDAPADAPTDAGLDGDLAAEVPGDVYHDLLRAEAIPDPFVEDNELDVQWVGETDWTYSRTIEVDGDRLTHDEHRLVFEGLDTVAEVFVNGDSVGRSDNMFQRYEFDVGSALSPGENEIEVAFESPVEYAAERAGAYPYDVRSIEFPVEQPHRNFIRKAQCHFGWDWGTCLPTVGIWRDAFLVSFSAPRITDVAVGQEHGENGAVDLDVDLRVESPDAGDYDVTLAFEDDDIDAAATESVALGSGVDEATVSVSVDDPDLWWPAGHGDQPLYDLHVEIAPDASGETVADAASERIGFREIELVREPDQAGESFGFEVNGQPVYSKGANWIPTDGIPTRVDDADYERLLSDAVDANMNTIRIWGGGIYERDAFYEACDEQGLLVWQDFMFACALYPSDDEFLDSVAAEAEYQVRRLSSHPSIALWCGNNENEEMLREWIGEGADDYDTYADDYDSLYLDTLEPIVESVDPDGRAYWPASPHSTSPDVLPNDNSEGDVHFWDVWHSGKPFSAYLDAEPRFASEFGYQSFPSIETLSDVLEPADMNPTAPLMEHHQRNPGGNGRILQRMVDHFRVPFSMEDFVYLSQVQQGLAIETAIEHWRRLKPHCGGTIYWQLNDMWQVASWSSIEYGGRWKALQHMARRFYAPVLVSITPVDEDGDPIGRDEDPGAAQVWVTSDEPHALDGDVEITAETFDGEILHEETVAADLDAQESAVVATLDPDALGAEGLDADLSDLLVRAEYTGEEDSYVAIEVLNVYKQLELPEVDLDVSVDGDEVTVAADGAALYVRLDPGALAGHFTDNFFHLAAGEERTVTFDRQEGEDGSVAEALSVTHLRETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4J0</accession>
    <name>R4W4J0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446051.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06040"/>
    <dbReference type="EnsemblBacteria" id="AGN01157">
        <property type="protein sequence ID" value="AGN01157"/>
        <property type="gene ID" value="L593_06040"/>
    </dbReference>
    <dbReference type="GeneID" id="16181606"/>
    <dbReference type="KEGG" id="sali:L593_06040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1237"/>
    <dbReference type="eggNOG" id="arCOG06276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018483_1_1_2"/>
    <dbReference type="OrthoDB" id="34757at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="5">
        <location>
            <begin position="600"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="897" mass="99289" checksum="6A94381BD0DE20CC" modified="2013-07-24" version="1">MTDERPPKPHALSVEPDGIPTALREDGAWLVWRYVWQEDREQWAKVPYHADGEHRVDATDPANGVDFPVALATYKRGTYDGLGVITDPDDPHLVFDLDDVVDPERRHESLPDLVREIVEELDTYTEYSPSQTGYHVWVEGEKPGEACRSDLPIDPVVEGETPHLELYDGSSGRYITVTGQHVCGTPETVEPRHEVTRSLYDEYLGAADAPDGPIDQPTPGRDNSLDDEDLLERAKAASNGEKFERLWNGGTAGYPSQSEADLALCGLLAFWTGGDREQMDRLFRQSGLYREKWDEQRGDRTYGQQTIVKTLQGNTEFYEPRDGSTGSPVSGPADHVSEPLLDAIREAPTDWIDPDAQAWSVRATEDFGASEIASAVRKGELPGDADDAIASAVMAGNFPDEIGAAFTAWNRKPDEWDVEVARYFDPGALDPGAIAADADVDPENLGGLPARELAHHVWTRVRRRDDVHVVARVGERGDGSLFSHDPDTGTWSETGAPKLRTIANEALGSAYSRCVGDELEERVRTTRAIDEPNGQVDVDEFGAPVESLPVANGLLEIGGRELGPLEPTDYALATLPITYDPDADCPTFEAFLEEVCPRSVDRQKLQEFVGYALMHWALPYHKALFVAGPQASGKSTFLDVVRRLLGPETTCSLAPQEITSERFAGYDLWGAWANIRSDIPAELIQNTGKFKEVTAGDPIKVEQKHKDPITIEPTAKHFFAANTLPSAEIDDDAFFRRILMVSFPRTVPRSERDPHLIDALADELPGILNWALDGLDRLRDQGHFSGDLPPAETHEKWQTWGESIQRFLHQCVDTDVAATATVPKGDLYDAYVRFCEEEGIPAESKQKFGREIMGKPGVGEKNARKDGRRVRVYTGIELDERRVTAEREGDQRGLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4N4</accession>
    <name>R4W4N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_06350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01217">
        <property type="protein sequence ID" value="AGN01217"/>
        <property type="gene ID" value="L593_06350"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06350"/>
    <dbReference type="eggNOG" id="arCOG03744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230488_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="105" mass="11556" checksum="1283A50F0D3329D2" modified="2013-07-24" version="1">MIEHLTEVKLHGDYATKEVMAKCDSGSESTSIHYDLIVEIGGAERLGQREVYSALGSEKRDTVQTSIELAGKRFDTKVDIGDRSGMDHKVLIGCDILKNFLIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4T8</accession>
    <name>R4W4T8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446221.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06900"/>
    <dbReference type="EnsemblBacteria" id="AGN01327">
        <property type="protein sequence ID" value="AGN01327"/>
        <property type="gene ID" value="L593_06900"/>
    </dbReference>
    <dbReference type="GeneID" id="16181962"/>
    <dbReference type="KEGG" id="sali:L593_06900"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1410"/>
    <dbReference type="eggNOG" id="arCOG01818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023388_0_0_2"/>
    <dbReference type="OrthoDB" id="3744at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="332"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="780" mass="86590" checksum="D45E45938E43CDD2" modified="2013-07-24" version="1">MATTGSATTATANPAPPVPAPVPPDDPDAWYAPDVREQTELCPGVVATIEAVDESFAYRIREPALSPGDEERLATILDHFGDATLSRPLTREGTREQIAAGFDEKYRRAIERLVDATNEGLRRVGYYALRDLRCLGELTPLALDQSIEVADAAEDALIVHTEHYAPAVTDLPGDPDFLDRFVSERLDTYTVAFREFEIPVVVYQEHLIGSDAFTTKYAVREPDLLPGDEALVEECKTKVWETNVDGVVEDRGAFVRERARLVLSRLLTARNTRAWFDATRYRVRSALATYDLAIPPIDDRFAEDRLEDLVYYVLRDYVGEGKLTIPIRDVHLEDIEANRVGERVKVVPRSTVSHDRRMPTNLVFEDETAFVNVVRQLAAADGVELNAANPSAKVNLAPEGVDDDVTIRCAVALPVISEDGPHVSIRKQAPEALTPVDLMAADSISPELVALLWQLYEHRCVVLFSGPTGAGKTTLMNAHMPFVRFEDRPISIDEGSREVRLPHETGVSLTTRDHEDDYKRVTMADLMTECNYLNPDIEVIAEINTPASFETFGETLNTGHGLVGTTHAEDVEKLVNRVVEQGLPPYLLREIDLVAFPKHVDGERYVGEVIEFLGPSEYVQVGGVCGAIEKGGSTIYWNRVAERDPTGTFHLNYDHPELPTDERASADLAPGERLERSAFDPPDNEAAVAEETDAATGAAGTASDATDPAPSCDMRVFHRIADRTDRPVQTVEAEFHRKLRYVRYLQREGLDDFEELFAFVADLETNEAATVERLRRRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4U8</accession>
    <name>R4W4U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/protn antiporter putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_06975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446236.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06975"/>
    <dbReference type="EnsemblBacteria" id="AGN01342">
        <property type="protein sequence ID" value="AGN01342"/>
        <property type="gene ID" value="L593_06975"/>
    </dbReference>
    <dbReference type="GeneID" id="16181971"/>
    <dbReference type="KEGG" id="sali:L593_06975"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1425"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_4_0_2"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="31"/>
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        <location>
            <begin position="94"/>
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        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="403" mass="41370" checksum="4F1DDD49A59F83F4" modified="2013-07-24" version="1">MADLLTVGALFAAIALGSVLAARLGTSVIPLYILTGMLVSPAVAGELVVAGYDVPAIQGGEFVEIGAELGIVFLLFFLGLEFNLERLVADRGRIVTAGTIDLAVNFGAGLVVGFLLFESLLAAFLLAGIVYISSSAIITKSLIDFGWIANDEAGPMLGTLVFEDLAIAVYLAIAVALVAGGNGVAGLATAVGLAMGFIVLLLLVVQFGSGAFERLLAGASNEFLVLRVVGVTVLVAGVALAIGVSEAVAAFFVGMAFASTSHVERLERLLEPVRDVFAAVFFVWIGLETDPVLVAEVAALVAIAVAATTPTKLFSGYLGGRAYGLSPRRSTRVGLGMVTRGEFSLIIAAVAIEGAGGTLSAAVASDIYAFAVGYVLAMSVLGTVLMQYSGPFERFAVGRFGME</sequence>
</entry>
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    <accession>R4W5D0</accession>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860676_0_0_2"/>
    <dbReference type="OrthoDB" id="92287at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AGN01657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="15384" checksum="6A2276848E0E9A4E" modified="2013-07-24" version="1">MRTVEVSRFVQAPPSVVERALDPASIVEYEGSFDVRTVEERDDAIVVIAGGTGLELSFRFELRENGIYYEQVEDEDAPLETMETELAWAAENEGTRIDATSTVGMGVWPRPITDRMATWKRRGELRRLFDSLAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5J1</accession>
    <name>R4W5J1_9EURY</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
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            <end position="193"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="667" mass="70060" checksum="F19B057FE8394397" modified="2013-07-24" version="1">MTRAHASDRTGDGAVYETEAATVRVRPRRIDEDRDALEYAIETDHPAPVRVRVRQPIPDSMAFEDLGFPGNCGEDWERDADGLVFEREIEPGEIASTAWGVDGDIGADLEPPVVEAAPAATDGEATPDPAATPEPVDENATGEERDEDAADAGGDGSATGADSDGQAVDAASENEDDASLELDLDELPDPMADDEPEAAARLPGETATDDGSGGEETGSDSASSATGPSTEGTAESGSDAVVPGETALDEGSMDEQSADEGGSGGALADDVFADVDAGASDGEAKEDPVDAPAGTSAEDASDDATESLVHRLVGELHDESVDDSHRAALADALEVRLSDSTNAFVEHVRERQRRRAERIADDVEALEESVEGLYGLKADASDVQTLKRAITDLDGAKAGDAELRELRSRVESLGETAADAETVAALREDHESLADALEATDDELADLEATSEADREAIRSEIESVADDLASLEARAATAERLDDLADDLETLRETAATEAALDELEETVEELEADAATTEELDGLRSDLDDRESSLDERIDLLTDRHDDLAADAATTSALESLREDHRERLNETTSDVQSLRETVESEYSTDDEIEAEIHRRVHRGLAHLLAFAIGAIGLVSTAPLAIVGSSAAAVTFVGGAVALGLWWRAVGPSGLADGPSLRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5U3</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.2057"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="206" mass="23039" checksum="0E26FA2753000596" modified="2013-07-24" version="1">MGLYDRYLALRVRASDAEPPEHVALVITERDLLEPGAYETLSTFLEWAFAYGAERVTVYVSVLDPEAIEALRRGLDAVDAPRAMAVHGPDESADERATSNAPIQVSVGLGGKHEFTQAVRSLAEAAAAGDLDPTTIDEGDIEAELVLSEEPDLVIKTGAERLSDFMIWQSVYSELYFTDVNWRDLRKRDYLRALREYADRSRRFGR</sequence>
</entry>
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    <accession>R4W5Z9</accession>
    <name>R4W5Z9_9EURY</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10435"/>
    <dbReference type="EnsemblBacteria" id="AGN02032">
        <property type="protein sequence ID" value="AGN02032"/>
        <property type="gene ID" value="L593_10435"/>
    </dbReference>
    <dbReference type="GeneID" id="16181943"/>
    <dbReference type="KEGG" id="sali:L593_10435"/>
    <dbReference type="eggNOG" id="arCOG07564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817895_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="339" mass="34905" checksum="680B473674C9DB07" modified="2013-07-24" version="1">MSQDDLAERLDAVERRLDAAYPDAAADGTTEQATDRIETFAERLADLEAAVEAVEGYVGEIERVDAELEQRADAALATADGLESRVEHLEARVGGDGSDLEERLAEQDAALAALRNEVEGLEDRIGERQADGDKSAAGDPLDEFAAVGAGDAPVDPTDDGTGQVYAGTRRDASSEREPDRVADSPGQCTCSDAPAGPPSAADSPPTAAARHSAPDGGVAISSRSEDPLDRRNASTESIEGAADQPPGTPGLGTTNSPASPEATGSSSPGDSTSREPGRRSHRASSSQSSVSGWGELGSGVDEPDADRSRSGDGRGTAEEDPGLADANTETLLDRLRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6H4</accession>
    <name>R4W6H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_02185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00388">
        <property type="protein sequence ID" value="AGN00388"/>
        <property type="gene ID" value="L593_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02185"/>
    <dbReference type="HOGENOM" id="CLU_2629883_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="77" mass="9334" checksum="CE3A7CCE98431171" modified="2013-07-24" version="1">MLFYYESQSQPISLKKDDFAQIVLMRCGRQSLVMEVERRPLRTSLTYSLDVRCNTRVFKRRFSVPFIKQRIKMVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J6</accession>
    <name>R4W6J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 5 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12120"/>
    <dbReference type="EnsemblBacteria" id="AGN02367">
        <property type="protein sequence ID" value="AGN02367"/>
        <property type="gene ID" value="L593_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12120"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2494"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410859_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="180"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="650" mass="71645" checksum="B5AFE1FCC3AA2BB9" modified="2013-07-24" version="1">MAQKANRVQDLTNRRRILQGLGALGVTSIAGCFGSGDGGGGGGGDGVNPVRDRVTVDPEDIVEGGTFSTAIPGGVDTFDEPYSSSAYATNMQGVLYEGLITTGADGTMYPWLASSYSQEEVNDVRAADYEPYMVEAEYGDEGAPQLDGQIVVEHPDNTGDGTDMFLTVNEAPDAVADGTYGMRYRFELEEGVEFHNGEEMTADNVVASYERTQGSALSGQVYDALLDVQADGDYAVDFYTQEPDAGFLRNTIIISIWPTEVTDLPPQAHDPRQGNEPMGTGPFVFEEFEPDQYFRATKNENYWFDTDKKDWFEGPDDFPNGPVVDEVDISIVPDPASRTAALRNGEVDLTFGLNTSNLTEFDNSENYRTAYTKGAGFNFFQFPVTVEPFTDARVRRAINHLIPRQQISDNIFNGWELPAWVPMPPLAAGMGTTDYDGMVEDLKSYNEYDQEEAASLVEEAVEENGWETPIEVTINTNANDDNRVAMCEVVVEALNQSDHFNASLDTYADLITMIGAFYQPSYAEEGNIAVVGLSGGFSPHGYAKAVHHPDNYLQCCNFQNIDDDDLNSLLQEARYGMEAVQDEEVRQERYEEVWERVLELNANSYGTHGATVGVHPTEGIYGFNTYPSTQSVVPYALYTPADEQITYIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6J7</accession>
    <name>R4W6J7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_02410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445327.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02410"/>
    <dbReference type="EnsemblBacteria" id="AGN00433">
        <property type="protein sequence ID" value="AGN00433"/>
        <property type="gene ID" value="L593_02410"/>
    </dbReference>
    <dbReference type="GeneID" id="16180191"/>
    <dbReference type="KEGG" id="sali:L593_02410"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_0_2_2"/>
    <dbReference type="OrthoDB" id="113911at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="169" mass="18356" checksum="8BC5AB27FC488C67" modified="2013-07-24" version="1">MHSDTERGDDDPGFDRPEADADATACHHTDYDTAGDRARPDAADGERVHRESVDGEVPATGHGADGLERRVWDALYGVEDPEMPISIVDLGLVYDLEVDEEAGTAAARMTLTYTGCPARDMLLDDVERAVASVDGIEDATVELVWSPPWEVELVTEQGKDALREFGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6R2</accession>
    <name>R4W6R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445422.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02885"/>
    <dbReference type="EnsemblBacteria" id="AGN00528">
        <property type="protein sequence ID" value="AGN00528"/>
        <property type="gene ID" value="L593_02885"/>
    </dbReference>
    <dbReference type="GeneID" id="16180367"/>
    <dbReference type="KEGG" id="sali:L593_02885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.583"/>
    <dbReference type="eggNOG" id="arCOG04469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043916_1_0_2"/>
    <dbReference type="OrthoDB" id="112841at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="413" mass="40646" checksum="7AD874E100C171B2" modified="2013-07-24" version="1">MGLPGVTPVLDLQLSLTLLTAVAGGTLLGTATGLVPGLHANNVALVLASVAVGLPGPRIAVAAAMLAAGVAHTFLNAIPALAIGVPDAEMAVSALPGHRLVREGRGREAIRLSVLGSSLAVVLAVPLAIPVTLAMLDVYPAIAANLRVVLAVVVVGMLAMERSRRSRFAGAVTFLLAAGLGWRFLDADPAAPLSAGGVLAPLFAGLFGAPVLLEALRGGGVPPQGDAAICESPGSVGAAAGAGTLGGAIVGYLPGISSAIAAVGVLVAMPGDLSERDYVVATSGVDTANSIFALFALWAIGSPRTGVLVGVADLGAPVNLPVLTAGVLLAGGLAAGITMVLGDPYLRVVGGLDHRLVAIGVLTLLVGISFLFAGFLGVGLFVAASLVGLIPVRAGAYRVHCMGVLIGPLLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6T8</accession>
    <name>R4W6T8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="5" type="ORF">L593_03085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445462.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03085"/>
    <dbReference type="EnsemblBacteria" id="AGN00568">
        <property type="protein sequence ID" value="AGN00568"/>
        <property type="gene ID" value="L593_03085"/>
    </dbReference>
    <dbReference type="GeneID" id="16180432"/>
    <dbReference type="KEGG" id="sali:L593_03085"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.624"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_2_0_2"/>
    <dbReference type="OrthoDB" id="104636at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="134"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="308" mass="31917" checksum="881CB4C9EEBD9B93" modified="2013-07-24" version="1">MDERAALRMLDTALPSAGDDAAVVDGQVVTTDMLHDATDFPDGTTRYTAGWRSVGASLSDVAAMGAEATSAVAVYAAPEFDESELLDFVAGASDVCESVDAAYVGGDLDQHVEFTVATTALGETEDPVLRSGAEPGDAVCVTGALGRSGAGFRYFQRWQDDGDEAALERANDLFQFPPRVAAGGALAEYASSMMDSSDGLARSLHQIAEASDCGVAIDSDRLPVHDGIEAVAMDAEDRLELTTFFGEDFELVLTVPAADLDAAQAACPIPLTKVGDVTEPGPADATEQPALTMDGAALPDRGYTHGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6T9</accession>
    <name>R4W6T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447411.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12890"/>
    <dbReference type="EnsemblBacteria" id="AGN02517">
        <property type="protein sequence ID" value="AGN02517"/>
        <property type="gene ID" value="L593_12890"/>
    </dbReference>
    <dbReference type="GeneID" id="16180233"/>
    <dbReference type="KEGG" id="sali:L593_12890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2643"/>
    <dbReference type="eggNOG" id="arCOG00134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_14_2"/>
    <dbReference type="OrthoDB" id="57700at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="406" mass="41480" checksum="31BE02614FDDD749" modified="2013-07-24" version="1">MPASTRRTIGRYDALVLTSLLWFLAKLLRYAFPPLFETLSVEYGVSTAALGWAFTGFMLVYAAMQFPSGVLADRLGPVGVLTVGAIGAAVGAFVVALEGPFALLVFAMLLVGAGTGVHKTVAIGLLSRTYPARSGRALGVHDTFGTFGGVVAPAIVAVVLGAATADWRVLFFLGGGTAVIVAGAFSIRVPRRLPDRPATHADADERPPLRAYATPFRRRRFVAFVAVTLCFGFAYNGVVAFLPLYLARTTGVSSATASALYALFFVVSLIQLGTGELSDRAGRLPVITGTIGLATASLAALVAVPTAGPALFGVPVLAAAVVATLGVGAHGFRPVRAAHLEALLPENLAGGGLGVVRTGLMGAGAIAPGVVGVLATAAGFRVAFALLLAVLGVALAVVLSLWLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6U8</accession>
    <name>R4W6U8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="9">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">carB</name>
        <name evidence="14" type="ORF">L593_12965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12965"/>
    <dbReference type="EnsemblBacteria" id="AGN02532">
        <property type="protein sequence ID" value="AGN02532"/>
        <property type="gene ID" value="L593_12965"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2658"/>
    <dbReference type="eggNOG" id="arCOG01594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="175"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="746"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="896"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="908"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGN02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121567" checksum="893F449495293CC3" modified="2013-07-24" version="1">MSDAQTDVDAEAPAEDGGDAVLAADGGEPSDAKGASSELRSDGGSDGEDRTILLIGSGPIQIGQAAEFDYSGAQACRALQEEGAEVVLVNSNPATIMTDPEMADEVYIEPITPEAIAEIIRKEEPDGVIAGLGGQTGLNVTAELAELGVLEEHDVEIMGTPLDTIYATEDRDLFRQRMHELGEPVPASTTISLPEGESTQKLGEDDLQQLVDDAVDEVGGLPVIARTTYTLGGSGSGVVDDKEELYERVRKGLRLSRNNEVLITESIEGWIELEYEVMRDADDSTVIICNMENLDPMGIHTGESTVVTPSQVIPDPGHQEMRNVALEVIRDLEIHGGCNIQFAWRDDGTPSGEYRVVEVNPRVSRSSALASKATGYPIARVTAKVALGKRLHEIENEITGETTAAFEPAIDYVVTKVPRWPKDKFEDVEFELTTAMKSTGEAMAIGRTFEESLLKALRSSEYEPDVVWDAVDDEELEAEYLERPTPDRPYAIFEAFDRGYTVDELRELTDIREWYLERFGRITGAARNAQDGEFGEAAELGFTDAQLAAGVDATQASELERADGGTVADVETQTPDRSFKQVDTCAGEFAASTPYYYSAREPAATDTSTGFDEVQVDRDLESVVVVGGGPIRIGQGVEFDYCSVHAVQALRDMGIDAHVVNNNPETVSTDYDTSDGLFFEPISAEEVADVVEATGADGVMVQFGGQTSVDVGEPLEDELARRDLDCEIMGTTVEAMDLAEDRDRFNELMDDLGIKQPDGGAAHSKEEALELAHEIGYPVLVRPSYVLGGRAMDVVYDDEALEKYIEEAARVSPDRPILVDDFLEGAVELDVDAVSDGEDVLIGGIMEHVESAGVHSGDSACMIPPRSLGRDVNRRVREVAEEIARALDTVGLLNVQLAVRDEEVYVLEANPRSSRTVPFVSKATGVPIAKLAAKVMAGATLEDLDVDEQVPGQTSIKEVVLPFDRLPGSDPRLGPEMKSTGEVMGTADTFGKAYQKAQMAVGKPIPLEGTAVVDLSESEFPAPDSAAGEELRAGYEEHFDLVDFEDDEAFVEAIQSGEVDLVISRRRKPLEAAVEEEITYFSTLPSAKAALEAIEAKDEPLDVHSVQSRPRMQEYWGQPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7C0</accession>
    <name>R4W7C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447701.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14340"/>
    <dbReference type="EnsemblBacteria" id="AGN02807">
        <property type="protein sequence ID" value="AGN02807"/>
        <property type="gene ID" value="L593_14340"/>
    </dbReference>
    <dbReference type="GeneID" id="16181172"/>
    <dbReference type="KEGG" id="sali:L593_14340"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2936"/>
    <dbReference type="eggNOG" id="arCOG04600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2662225_0_0_2"/>
    <dbReference type="OrthoDB" id="119941at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043813">
        <property type="entry name" value="DUF5795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19108">
        <property type="entry name" value="DUF5795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="75" mass="8201" checksum="1E20A39AAFF353A9" modified="2013-07-24" version="1">MSENRVVQGRMVTPVSLAEIVEGEGVIDAEAIEDADRECPECGGDVLAVGYMPTVTEFVTGYKCQECDWAETDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G8</accession>
    <name>R4W7G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447796.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02902">
        <property type="protein sequence ID" value="AGN02902"/>
        <property type="gene ID" value="L593_14840"/>
    </dbReference>
    <dbReference type="GeneID" id="16181840"/>
    <dbReference type="KEGG" id="sali:L593_14840"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3031"/>
    <dbReference type="eggNOG" id="arCOG02827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080901_0_0_2"/>
    <dbReference type="OrthoDB" id="53151at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="303" mass="32450" checksum="CBE310D4B10E7BD1" modified="2013-07-24" version="1">MTDDSPDNVLFEWYERFIGEPEAETDVYLGFGLFFTAIGLALLALVLFVVGVAAYGIREDGYFAVARVAYASGMLSVPLAMFSIVVLLPVKQRATMAAGAGVAVTVAAVVGFAVVYPDNWFDYGGTQTLYIVSGYAVGLMVVTAATGAALVAHHLQRTKAPAPSEIKAQEEEEDEETYTTEEIERDIEEAMADVEMTWGGVEKSENRRLKLNTDFADAELQAGGLGLEGNKTVESGGVDDQVQGLRNLKGGETKTATSESTVDNQTAALNELKQQKKEDQVPTNAPTASSSFLGRLLDRLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7H3</accession>
    <name>R4W7H3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445862.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05095"/>
    <dbReference type="EnsemblBacteria" id="AGN00968">
        <property type="protein sequence ID" value="AGN00968"/>
        <property type="gene ID" value="L593_05095"/>
    </dbReference>
    <dbReference type="GeneID" id="16181282"/>
    <dbReference type="KEGG" id="sali:L593_05095"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1040"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_0_2"/>
    <dbReference type="OrthoDB" id="40216at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="392" mass="40157" checksum="11D4EB2EE78C3E16" modified="2013-07-24" version="1">MVGILLVVGVVVAMFVAYNIGGSTTGPAFGPAVGADAISKTTAAALMGVFFFIGAWTLGRNVVTKLGSELVVDPGVFTLETSIAVLFFIGVALLMGNLFGVPASTSMTAVGAIAGLALAGGVLDVAVMGEILTWWIVSPVIGFWVSLIIGRYFYARLNRMVAIERSSGPLIEVDRSGAVPLPKLHRTTNRRELIGTVTVVAIGCLMAFSSGTSNIANAVAPLVGSGEVAMNPAIIVGGIAVTIGAFTIARRTLETMGSDITELPLTAAIVVASVSSTLVIFLSALGIPASFVIIATMSIVGLGWGRATRPVTVPEAVSGGESPPVTVDALAADEAGEELPPIGEEDVEDIPSPGSLFNPATTARVVLMQNIVPAIATVGSYLTFRFVPLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7R2</accession>
    <name>R4W7R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05920"/>
    <dbReference type="EnsemblBacteria" id="AGN01133">
        <property type="protein sequence ID" value="AGN01133"/>
        <property type="gene ID" value="L593_05920"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05920"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1213"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="527" mass="54925" checksum="C4750E813F56E3C8" modified="2013-07-24" version="1">MSGPDDDSPESGGSGPPEPASDEPDSLLGKLGAMFGDQENLELTDGPIGKPLLYLSAPIIVTNLLQVAYNLADTFWLGQYSTEALAAVTFGFPLVFFLISLGMGVAVAGSVLVAQHTGAEEYEQAEFAASQTVTYAVLFSVVLGSIGYFFVGDFVRALGAGPDVAPQAANYLEVMSLGLFAMFGFIVFIDLMRGAGDTVTPMLVMFGTVFLNVVLDPFLIFGVGPFPELGVQGAAIATVFSRVVAMGVGVAIMFRGYHGIQIRLGEMVPDPTYARRLVRIGGPATVEGTGRSISVNMMLFVVGTFSTPIVAAFGVGVRVFSLIFMPAIALDRGVETMTGQNIGAGKPDRAAVANHVAARISFLILAGVGVVVFVFAPQIVAVFDSDPEVVRVGSDFLRWVAPTFGFIGIVRAYSGGFRGAGKTLTAAALAIIMLGVIRVPLAWVASRSIDVSTIGVDVPGFGRLSADVLAGTAIADLLAGSMSETGIWLAFAVSNVAAAALAYAWFTRGTWRDADLTGEPSPAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7X8</accession>
    <name>R4W7X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446192.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06755"/>
    <dbReference type="EnsemblBacteria" id="AGN01298">
        <property type="protein sequence ID" value="AGN01298"/>
        <property type="gene ID" value="L593_06755"/>
    </dbReference>
    <dbReference type="GeneID" id="16181869"/>
    <dbReference type="KEGG" id="sali:L593_06755"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1380"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_2"/>
    <dbReference type="OrthoDB" id="90282at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="13673" checksum="1687CDB79F73A3FE" modified="2013-07-24" version="1">MEEVSTDEAPPSIGPFSQGVIDDGQVFVSGQGPIDPDSGEIVGDDIREETHQTMQNVGAVLEAAGSSLDDVVKAQVFVRDMDNYDEINDVYAEYLSEPYPARSAMQVERLPVEIGVEIEVIGRVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W859</accession>
    <name>R4W859_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif1a</name>
        <name evidence="8" type="ORF">L593_01965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="STRING" id="1333523.L593_01965"/>
    <dbReference type="EnsemblBacteria" id="AGN00344">
        <property type="protein sequence ID" value="AGN00344"/>
        <property type="gene ID" value="L593_01965"/>
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    <dbReference type="GeneID" id="16182379"/>
    <dbReference type="KEGG" id="sali:L593_01965"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.399"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OrthoDB" id="102432at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="11144" checksum="5687D068AC1D819F" modified="2013-07-24" version="1">MSEEQERRNLRMPSDDEVFAVVTEHNGGNHVRVQCADGEDRMGRIPGRMKYRTWISEGDVVLVEPWDWQDEKANIEWRYSEQDADQLREEGHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W877</accession>
    <name>R4W877_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446442.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01548">
        <property type="protein sequence ID" value="AGN01548"/>
        <property type="gene ID" value="L593_08015"/>
    </dbReference>
    <dbReference type="GeneID" id="16182264"/>
    <dbReference type="KEGG" id="sali:L593_08015"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656843_0_0_2"/>
    <dbReference type="OrthoDB" id="131292at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="18380" checksum="E56918EC49B5E21A" modified="2013-07-24" version="1">MELLPVLGAVLGDASVLASGDLLLQNTGGFEQEQYTNRATPGSSFVATLVVGALLIGLANDYVTEIAEYIENKPVASFAWGVGAMIGFVVVFVLLAITVVGLIVAIPLAFVFVFVAIAGNVLAFIAVTEQFVDERWVALLVAAVVTAVLNAIPGVGSLVSFVIGSIGLGAVVRHWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W899</accession>
    <name>R4W899_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_08265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446492.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01598">
        <property type="protein sequence ID" value="AGN01598"/>
        <property type="gene ID" value="L593_08265"/>
    </dbReference>
    <dbReference type="GeneID" id="16180728"/>
    <dbReference type="KEGG" id="sali:L593_08265"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1694"/>
    <dbReference type="eggNOG" id="arCOG04630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754671_0_0_2"/>
    <dbReference type="OrthoDB" id="87493at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043858">
        <property type="entry name" value="DUF5820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19137">
        <property type="entry name" value="DUF5820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="126" mass="14538" checksum="AF932CBD0A0DBA3C" modified="2013-07-24" version="1">MDDPPAGWEVWNEGEDGRLILAYRPDVFDGDAFPAACMPTLYCTRGRRNSRRPGPERDAAADWFVTLFLEPEVTVAEERFDRREDALDRLRTVAADFAEGAIDYRDSYQVPRDDYLDELDALTEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8D7</accession>
    <name>R4W8D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03040"/>
    <dbReference type="EnsemblBacteria" id="AGN00559">
        <property type="protein sequence ID" value="AGN00559"/>
        <property type="gene ID" value="L593_03040"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03040"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.616"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490594_0_0_2"/>
    <dbReference type="OrthoDB" id="25049at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9311" checksum="173A4CD62DB55531" modified="2013-07-24" version="1">MEERTLDLAGRLAGGVPEERLLSPSEPESGLVTIDVPDPEATVERLREDGIVVRPLPFPDAIRASVHAVNTAEEVDRLLEGLEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J8</accession>
    <name>R4W8J8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09565"/>
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            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
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        </location>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
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        </ligand>
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            <position position="97"/>
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        <ligand>
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        </ligand>
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            <begin position="256"/>
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        </location>
        <ligand>
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    </evidence>
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            <dbReference type="EMBL" id="AGN01858.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="307" mass="32426" checksum="357940FC6479F7AA" modified="2013-07-24" version="1">MSDEDHGSAQPGGDGDGPATDGAGDAATEAASQSAVENAIPDVSSADDGADGGDGSDEPDHTPDDHPRSEDLETRHRIEAGVEKGITHIQGMHAEGRGTAFDYLLGEETIPSADDAARAAAAQLLLAEHPVLSVNGNVAALVPEEYVELADVVGADLEVNLFNRTEERMAAIAEHLREHGAEEVKGLTGDGEVPEVGHYRGIVDADGIEDADVVLVPLEDGDRAEALGKMGKTEIVIDLNPLSRSPQTATIPIVDNVVRAVPTITEHARTLRADGATREELEAIVERFDAQEHLRQAEEQIRTAAWE</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AGN00744.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="298" mass="32701" checksum="FB3C33516C23E41B" modified="2013-07-24" version="1">MPSHGNRSRRTVLLAAGGTLASALAGCADVASKLPGDDGDDSTESTLRARIEDYFAAVEGENPDALAEVVHPSSPMHPDYWDDNDDWEFQGYATEDGATNVDYEIDAVQTDATVADVRTLEYAEFWFEGDELETILDGEDVAIVELDSDVLEANEQDHWVFATADGEWRLFLASTESSVPTDPEDAFQEPIHDQANDVVDRIDWDYEPSSDGEGREQNTEWARVVLTDDPGIDADTIRVESTIADAEAEFYSEQNGPVSSTWAGSWASIPLHPEGDQIVVTAIDDGEETVVHRVHYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
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                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
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    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
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    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
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    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="142" mass="15453" checksum="CD247596CC4A38B4" modified="2013-07-24" version="1">MANGKYAGRKLQRDRQKHRWSDSEYARRERGLAEKSDPLEGAPQARGIVLEKIGIEAKQPNSAVRKCVRVQLIKNGKQVSAFCPGDGAISFIDEHDEVTIAGIGGAKGRAMGDISGVNYKVEKVNGVALLELVRGNAEKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8T1</accession>
    <name>R4W8T1_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_10590</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN02063">
        <property type="protein sequence ID" value="AGN02063"/>
        <property type="gene ID" value="L593_10590"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_10590"/>
    <dbReference type="eggNOG" id="arCOG10802">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="100" mass="11233" checksum="619646DCD75C4626" modified="2013-07-24" version="1">MDRTPCPEIDLERDEGSADTSRRGRAARTHMTDDHRPDRSISSAEEFEAALAAVVEAAIHADVDVRGAWEFETGGSTYDWEVQIVELARDLDADREEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Y6</accession>
    <name>R4W8Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
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    <dbReference type="EnsemblBacteria" id="AGN01049">
        <property type="protein sequence ID" value="AGN01049"/>
        <property type="gene ID" value="L593_05500"/>
    </dbReference>
    <dbReference type="GeneID" id="16181370"/>
    <dbReference type="KEGG" id="sali:L593_05500"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1124"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="32874" checksum="782BA87FBD6D6FD2" modified="2013-07-24" version="1">MIEVEALRKEYGGFVAVTGSTFAVDAGEVFGIVGPNGAGKTTTLKMLAGLLEPTDGTATVAGRDASDPEMRRNLGFLPEESPLYEEMTARSYLSFFADLYDVHRDTASNRIEDSLDRLELEHRDRKIGDMSKGMTRKVAIARALVNDPDVLIFDEPASGLDPRTTNYINDFVGELADRGKTVVFSAHNLYHVEDVCDRVAIMNEGDIVARGTLDAIREEHGRSAYHVYTDVAIEGSVRENGRYKRVVTAYDDIEQVRDAADAAGGRVLDVRTEGSSLEEIFLDLAGDDEGSIGSDSQEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8Z2</accession>
    <name>R4W8Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_05625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445968.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05625"/>
    <dbReference type="EnsemblBacteria" id="AGN01074">
        <property type="protein sequence ID" value="AGN01074"/>
        <property type="gene ID" value="L593_05625"/>
    </dbReference>
    <dbReference type="GeneID" id="16181445"/>
    <dbReference type="KEGG" id="sali:L593_05625"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1150"/>
    <dbReference type="eggNOG" id="arCOG00246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_2"/>
    <dbReference type="OrthoDB" id="69007at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="147"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN01074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="304" mass="32784" checksum="72DC5D836BD9498C" modified="2013-07-24" version="1">MTKVSVVGAAGTVGAAAGYNLALRDVVDELVFVDIPDQEDTTIGQAADTNHGIAYDSNTRVRQGDYADTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIMDDIGSSLAEHNDDFVTVTTSNPVDLLNRHLYETGERAREKVIGFGGRLDSARFRYVLSERFETPVKNVEATILGEHGDAQVPVFSKLRVDGTDPEYDADEKEAILGELQESAMDVIERKGATQWGPATGVAHTVEAILEDTGEVLPCSVVLDGEFGYEDTAFGVPVKLGSNGVEEVVEWELDEYEEELMDDAAEKLSEQYDEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W989</accession>
    <name>R4W989_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MCM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447372.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12695"/>
    <dbReference type="EnsemblBacteria" id="AGN02478">
        <property type="protein sequence ID" value="AGN02478"/>
        <property type="gene ID" value="L593_12695"/>
    </dbReference>
    <dbReference type="GeneID" id="16180127"/>
    <dbReference type="KEGG" id="sali:L593_12695"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2605"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OrthoDB" id="3067at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="7">
        <location>
            <begin position="274"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="629"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="697" mass="77903" checksum="D1A189DFA7BC882F" modified="2013-07-24" version="1">MATGVDQQEYVDTFEQFFREYYRTEIGALARGYPSEQKSLVVDYDDLYRFDRELAETYLEQPEQLQRSAEEALRLYDLPVDVTLGQAHVRLRGLPSSTDIREIRASDVNTMVSVRGITRKATDVRPKCTEAAFRCVRCETLTRVPQEGGKFQEPHQCRSCERQGPFRLNEDQSEFVDAQRIRVQESPEGLRGGETPQAIDVNIEDDVTGEVTPGDHVVVTGILRLDQDGENESPIFDVYMEGVSVEVEEEQFEDMDITEEDTAQILELSQRDDVYEQMIGAIAPTIHGYDEEKLAMTLQLFSGVTKHLPDESRIRGDLHILLIGDPGTGKSQLLQYVRNIAPRSVYTSGKGSSSAGLTAAAVRDDFGDGQQWTLEAGALVLADQGIAAVDELDKMEANDRSAMHEALEQQSISISKAGINATLKSRCSLLGAANPKYGRFDQYEPMGEQIDLEPALISRFDIIFTVTDQPDPEKDRELADHILEANYAGQLNTQREQMSAPDVTLDQVEDAQETVEPTIDPELLRKYVAYAQQNCYPRMSDEAREAIQEFYVDLRSKGADEDAPVPVTARKLEALVRLAEASARVRLADEVAVEDAERVISIVRSSLQDIGVDPETGQFDADVIETGTSKSQRDRIKNLKALIDDLADEYEEGVPVDAVYDRADEIGIGAEKAERELEKLKQKGEVYEPKTDHVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9A4</accession>
    <name>R4W9A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06860"/>
    <dbReference type="EnsemblBacteria" id="AGN01319">
        <property type="protein sequence ID" value="AGN01319"/>
        <property type="gene ID" value="L593_06860"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06860"/>
    <dbReference type="HOGENOM" id="CLU_2177992_0_0_2"/>
    <dbReference type="OrthoDB" id="81834at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="11919" checksum="FFC313266007DA9E" modified="2013-07-24" version="1">MRRRRPRSWHPTGEVDGDVGEESPDGLEPANYADYALHYVPDRFAYYERGDGCLPTLAGACCVPPRPLATVVVLYLEPLTDRMGECIVPSTSTPTPPAADRVAFVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9D2</accession>
    <name>R4W9D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446293.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07260"/>
    <dbReference type="EnsemblBacteria" id="AGN01399">
        <property type="protein sequence ID" value="AGN01399"/>
        <property type="gene ID" value="L593_07260"/>
    </dbReference>
    <dbReference type="GeneID" id="16182072"/>
    <dbReference type="KEGG" id="sali:L593_07260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1482"/>
    <dbReference type="eggNOG" id="arCOG03655">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176775_0_0_2"/>
    <dbReference type="OrthoDB" id="110904at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="98" mass="11660" checksum="9DCBE6BBAE67C7DE" modified="2013-07-24" version="1">MTLAERIDEFLDTLKLWARGLYHGMLTHPAYETLEKEAEDLEDAFMLACFPDAFGIPSPVSYYTAEFLPYLADEFEAWQRRMWDRDSLIERKGQQYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9K8</accession>
    <name>R4W9K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rnd superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_14020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447637.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14020"/>
    <dbReference type="EnsemblBacteria" id="AGN02743">
        <property type="protein sequence ID" value="AGN02743"/>
        <property type="gene ID" value="L593_14020"/>
    </dbReference>
    <dbReference type="GeneID" id="16181016"/>
    <dbReference type="KEGG" id="sali:L593_14020"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2868"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003088_0_0_2"/>
    <dbReference type="OrthoDB" id="5636at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="283"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="695"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="873" mass="91834" checksum="E65035ED9341B8C5" modified="2013-07-24" version="1">MDRDLADRYADVLVDNSRIVIVVLLLLTAIVGAGAVVGSSEEGTIGEFQTESPEREALDEIEDTYGTDDTTVAQIVVRDREGNVLTKASLLEGLYLQQAIRSDESIASTLVEENAIGGLENVVATAAYYEDNPATAAPGGNDTNASSGGAPPAGPTLQEQIAALEGRSSAEVEALLERVLDPETDVRAGDPYRYLPTSYEPGTTTAESRITFVFQSDPTGADEVPTEAYEAQVAIDDLVQDRFEDGFVFGQGISDDASSRAVGDSFLIITPVALVLVLFVLGVAYRDVLDVLFGIFGILVVMTWLGGVQGWLQIPSSQLLIAVPFLLIGLSIDYSLHVVMRYREAREGSLDTDTEATGRRSPSAAMRVGVAGVGVALAAATFSTGIGFLSNYVSPLVAIQNFALLSAAGILATFVVFTALVPAVKLEVEKLLDRRGRERHKPAVGVTAGPINRLLSGLGRLARRAPLAVVIVALLLGTAGVYGATTIDTEFNRADFLPEDAPDWAKSLPGPLSPGDFDIRENVAYLSENFRQRGEGTEAQILIRDGVTDPATLSAIDASTSEASPDDAIADRADGSVAAETPATVLRDVAAENERLAAAIEERDDDGDGLPDRDVAAVYDVLFEVAPDRGASVLYRTDDGSYASGRLTVGVRGDASAQTVASDVRSLARSIEADAPVSAVATGGPVITAVLQDALLETLVQALAITLVVIGVFLLGLQWYRYGAPDLALVTMTPVVVALAWLLGTMAAFDLPFNSETAVVTSLAIGLGVDYSIHFAERFVDERRRHDGVEDALTATITGTGGALLGSAATTASGFGVLALALSPPLQRFGTVTGLSIVYAFVACLTVLPSLLVLRERVIAWRNGREAEEPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9M1</accession>
    <name>R4W9M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447677.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14220"/>
    <dbReference type="EnsemblBacteria" id="AGN02783">
        <property type="protein sequence ID" value="AGN02783"/>
        <property type="gene ID" value="L593_14220"/>
    </dbReference>
    <dbReference type="GeneID" id="16181148"/>
    <dbReference type="KEGG" id="sali:L593_14220"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2911"/>
    <dbReference type="eggNOG" id="arCOG01359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533842_0_0_2"/>
    <dbReference type="OrthoDB" id="19362at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="185"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="592" mass="64403" checksum="96EFDA91DE430228" modified="2013-07-24" version="1">MTADPAAIDVTIVDGYVDEPAHFGVPPYISTYPRYAAGAMVDAGVPEERITYHTIDELRDERNRWADVANADLMLYIGGMTVPGKYVGGTPAEPDEVRELAWTAEGVSVMGGPAKFGVGEENAGGIETERDDLDFDFLAMGDVEAAAHDIVESGLEGFNGRYRDVEEVTRWAQKGAFVVEEHPNHPEYLICEMETGRGCPYRCSFCTEPLYGDATFRPPETVVGEVEALADHGVRNFRLGRQADILAYGGDGEKPDPDSLRELYGGIREAVPDLETLHLDNVNPITIVKWPELSREGLGVIARHNTPGDTAAFGLESADPVVQEANNLNVTADEAFEAVKIVNEVAGWRPEDDQPPFDSGAPGEPPGDRDADVEAPTFGDGAPRRLPKLLPGINLLHGLKAEREETFEHNEQFLQRVYDEGLMLRRVNIRQVMAFPGTDMDETGAQIANDHKKLFKQYKSRVREQIDNPMLQRLAPPGTVLPDVTLEYHQDGTTFGRQLGTYPLLVGVPGERDLGQTIDVAIVDHGYRSVTGVPFPLDLNAASMTELAALPGIGKQRAGDIVVNRPYDSVADLGVDADLSAFVTTGNPAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N3</accession>
    <name>R4W9N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447712.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14395"/>
    <dbReference type="EnsemblBacteria" id="AGN02818">
        <property type="protein sequence ID" value="AGN02818"/>
        <property type="gene ID" value="L593_14395"/>
    </dbReference>
    <dbReference type="GeneID" id="16181233"/>
    <dbReference type="KEGG" id="sali:L593_14395"/>
    <dbReference type="eggNOG" id="arCOG07782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542526_0_0_2"/>
    <dbReference type="OrthoDB" id="131322at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="569" mass="60879" checksum="E8FBEE40BBF827C8" modified="2013-07-24" version="1">MTEASPQPTVSRRTLLRSGAVAAGGAMGMGAATEYGAIGNVRACPLCIGAAIVGAGMVGYALGRESAPEPDRSAEQAEADWENWVTFYNRARQIGTHDKTQLEQARRDANGMANLARRDAILAIYNEAVGGSSKSQSRTAAEDAVNAAFTETLKGVLNHHTSRITELEGDMQLINSSDFTTQASKVIEAYESTGDRWVTPTHSVPESGTSGGSQNNIFPPSSDGFANSDITLPNGDTVSAPVKKSINSKVWLDGDYKDAVATMLTPWPEHLAVQAYNNPSVLKDTSSQTLKYFDLLTNPRIREPNPDEYDSVNESEVDTSDFDGHQVYLHETKFVEVVEEIETIRQNVLEEVDLLVDTHYDAAKNGDISLPEMTASQGLLEAARNADSFREVALAFRTMGWAVADTATVIRFQDSQGNVREVDSKLAWARQDQPDSLEVGLEYDAGQLPGTLYIAYNYTDQNGETAATYGALGGKFTIVATESGSSTVGFEHRGVVETSDSPTDVQDEFRDTNDAEQDAEEARQDINVTSGGFTLFGGNGGLGGGLGRIVGGAIVVIGALFGINLVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9N9</accession>
    <name>R4W9N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_14495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447732.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14495"/>
    <dbReference type="EnsemblBacteria" id="AGN02838">
        <property type="protein sequence ID" value="AGN02838"/>
        <property type="gene ID" value="L593_14495"/>
    </dbReference>
    <dbReference type="GeneID" id="16180200"/>
    <dbReference type="KEGG" id="sali:L593_14495"/>
    <dbReference type="eggNOG" id="arCOG00979">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_4_0_2"/>
    <dbReference type="OrthoDB" id="93078at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="222" mass="24705" checksum="E654C1B0EB40827C" modified="2013-07-24" version="1">MTLLSDDIARFVRATGPEPDDVLEEMDEYAEEHGFPHVGSALGGWLQFLARMVDAEHVFEFGSGYGYSAYWFARALPDDGRIVCTEIDEDEIEMGREYLARGGFGDVVSYEHGDAVEIVDRYDGPFDVVLIDHQKHRYAEAFEAVRDKVAPGGIVVADNVMTGGTIDFDALLEAWHGEEPLASDDEMTRGIDEYLHTVRDDPAFETTVLPLGEGLSVSHREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9R3</accession>
    <name>R4W9R3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446593.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01699">
        <property type="protein sequence ID" value="AGN01699"/>
        <property type="gene ID" value="L593_08770"/>
    </dbReference>
    <dbReference type="GeneID" id="16182412"/>
    <dbReference type="KEGG" id="sali:L593_08770"/>
    <dbReference type="eggNOG" id="arCOG14292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490563_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9656" checksum="4BA297862AAAA7D7" modified="2013-07-24" version="1">MTESTGGADGKPLRTRVWQLAVSIVLLTGVTVIVGYGGGLLLWLSARLGGPDPMTDDGDLLRDRLLDWPERNREFMRTDGHGELPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S0</accession>
    <name>R4W9S0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holliday junction resolvase Hjc</fullName>
            <shortName evidence="10">Hjc</shortName>
            <ecNumber evidence="10">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hjc</name>
        <name evidence="11" type="ORF">L593_08870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Holliday junction resolvase Hjc family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446613.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08870"/>
    <dbReference type="EnsemblBacteria" id="AGN01719">
        <property type="protein sequence ID" value="AGN01719"/>
        <property type="gene ID" value="L593_08870"/>
    </dbReference>
    <dbReference type="GeneID" id="16182562"/>
    <dbReference type="KEGG" id="sali:L593_08870"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1819"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139546_0_0_2"/>
    <dbReference type="OrthoDB" id="97278at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00523">
        <property type="entry name" value="archeal_HJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01490">
        <property type="entry name" value="HJ_Resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
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        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN01719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="165" mass="17879" checksum="E69B3D6E405B01C0" modified="2013-07-24" version="1">MSNAKGDRRERELVNELDATGFAVMRAPASGSATERELPDVLAGDGEAFYAIEAKSSAGDPIYLTAEEVEALIYFAQNFGARPRVAARFDREDWYFFHPDELHSTASANRRVKKEFAIESGETLEELAASGPTTDDEPSVATLDICNAVADGTLEPEEGAEMIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9S9</accession>
    <name>R4W9S9_9EURY</name>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ORF">L593_15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02958">
        <property type="protein sequence ID" value="AGN02958"/>
        <property type="gene ID" value="L593_15120"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="10352" checksum="4519CF28426B0DB9" modified="2013-07-24" version="1">MTKWLQSGLRRDVCIVLAGEGELHGQQLKARIAAHYDERIDPSTFYGALEALVETGHLEVHEDGLHDAYALTDAGRSMVEEQFAWMRSHVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA08</accession>
    <name>R4WA08_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_10920</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02129.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="1333523.L593_10920"/>
    <dbReference type="EnsemblBacteria" id="AGN02129">
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        <property type="gene ID" value="L593_10920"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2379546_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="94" mass="10035" checksum="314F679D0F9D3920" modified="2013-07-24" version="1">MDEVTRRRGRLLLVVVLAVALCSAPVLGHSGHESHESREDTRLSPWPFFFVFGTVTAGGSLLAGHRFDVPRQYAIGLATGGGAMALVAAVVWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA56</accession>
    <name>R4WA56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_12130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12130"/>
    <dbReference type="EnsemblBacteria" id="AGN02369">
        <property type="protein sequence ID" value="AGN02369"/>
        <property type="gene ID" value="L593_12130"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_12130"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2496"/>
    <dbReference type="eggNOG" id="arCOG00624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111003_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="58"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="193" mass="19996" checksum="4C11C775AFFD473A" modified="2013-07-24" version="1">MPVSDPSPNRVDTWSVGHIVRTMAPLLLVLSVLELGSGLVLESLQSTYLGNPTLLVLVPVMIGMGGNLGAIMAARLSTQLHLGTISFDPREPQLRAGILAIMGLAATVFTVLAIVAYGLGHLLGSPMALSDLLTISLVSGLSLAAIAVSLGIAATYVSYRRGYDPDDVTVPVVTNVCDILGVLILSVVAIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA68</accession>
    <name>R4WA68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447323.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12450"/>
    <dbReference type="EnsemblBacteria" id="AGN02429">
        <property type="protein sequence ID" value="AGN02429"/>
        <property type="gene ID" value="L593_12450"/>
    </dbReference>
    <dbReference type="GeneID" id="16180627"/>
    <dbReference type="KEGG" id="sali:L593_12450"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="323" mass="36065" checksum="F9ADA663465157D7" modified="2013-07-24" version="1">MDTTPLGATGESVSELCLGPMYFGSKVDRETSFALLDRYYEAGGRFLDTANIYATWVDGYDEPESEPLVGEWLADRGVREEMTIATKLGFGYQDVPTSLDPELIHQEVDRSLERLGIDTIDLLYAHVDDPDTPQIDVMEAFGEAVDEGNVRHLGASNVPAWRVARANRIAAEQGLPRFECVQPRFSYLIPDRDAAFGGQLPTTDELVDYCTQHDLTLLPYSPTLQGCYGRDDRPIPDGYVRSENRQKLRVLEDIAEEKGVNGNTVALAWLLDRDQPTVPVLGVSTLDQLEQNLAAADLTFTDAERHRLNEIESYGFGEWDQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAA2</accession>
    <name>R4WAA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447493.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13300"/>
    <dbReference type="EnsemblBacteria" id="AGN02599">
        <property type="protein sequence ID" value="AGN02599"/>
        <property type="gene ID" value="L593_13300"/>
    </dbReference>
    <dbReference type="GeneID" id="16180519"/>
    <dbReference type="KEGG" id="sali:L593_13300"/>
    <dbReference type="eggNOG" id="arCOG03403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157708_0_0_2"/>
    <dbReference type="OrthoDB" id="113688at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="109" mass="12362" checksum="B7685405246FB641" modified="2013-07-24" version="1">MQPERGDVVRSADPFKLGNDRQRPWLIVNNDSHPFGGEQFLAVAISTKEYEDSLALTDEQWTTGGVPRESFVSPWAVHSPRSEDLIAWQGRVTEGFVDEVVESIENYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAC0</accession>
    <name>R4WAC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_13750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447583.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13750"/>
    <dbReference type="EnsemblBacteria" id="AGN02689">
        <property type="protein sequence ID" value="AGN02689"/>
        <property type="gene ID" value="L593_13750"/>
    </dbReference>
    <dbReference type="GeneID" id="16181590"/>
    <dbReference type="KEGG" id="sali:L593_13750"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2812"/>
    <dbReference type="eggNOG" id="arCOG04651">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2802370_0_0_2"/>
    <dbReference type="OrthoDB" id="128088at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN02689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="65" mass="6924" checksum="7DC9B29B9082ECA7" modified="2013-07-24" version="1">MPEPSSLRDSTQIVLPAATLEGLCADLEERFTVTIVGDGPCRIIGSPVEIKKANDFLARNGVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD3</accession>
    <name>R4WAD3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_14075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14075"/>
    <dbReference type="EnsemblBacteria" id="AGN02754">
        <property type="protein sequence ID" value="AGN02754"/>
        <property type="gene ID" value="L593_14075"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14075"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN02754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="327" mass="35328" checksum="90CD8BEA99EF92CB" modified="2013-07-24" version="1">MAGGVPTPPTDDTDQSEGEVTESRRPSERLAEGLPLAPGRIVLYLALLAGLVFYLIPLHSGLMTAISQGISGVPYAPPGLDEFTLDNWGTAYESVRPGLINSFLFVLPATVLSATFGSLAAFGLTKLSWRGQIGILMLFVAGVFIPYQSVLVPLRLFWGQMALAGSLELLGDSLIPPLSSGAYWLANHSDLIELTITHTAYGIPICTVLFRGYYLTIDTDMIEAAQVDGASMFTVYRRIILPLSKPMFAVTMIYQFTNIWNDLLFALILVTDSEQQVATQQLQQLFGSMTTNFPVVIAAAFVVATPTVIIYVLFGKQFAEGITGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAD8</accession>
    <name>R4WAD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02779">
        <property type="protein sequence ID" value="AGN02779"/>
        <property type="gene ID" value="L593_14200"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14200"/>
    <dbReference type="eggNOG" id="arCOG02782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830597_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="334" mass="36713" checksum="34F406D63E333277" modified="2013-07-24" version="1">MAAIPPQTFVRRLQTLDRAAFADFLADLWAACGWDTRIDGAVVTASNGADVKRIAVLPPRRFSGRRLRRIARRWQSVSLPDDADVVAWAGRGSAAPPVTGDRPILDADDLRDRVLFGVDPPVADELCERHLGRPARDERWNQTAPQRRRWIPTRPARSRSTASGQRTTRDGVLSTGIAVLVVLALIAGPVLYSNAVGSFGDPFGDDGQASATPVPEPTCERSPAEVATTVGEALQPPEVGASGMHTFWQFTVRDLRESMHYRAFRGYYEGPRFAALREADQVASEIVEREGDRATVTALARTDQNTAWYVFQLDRHEDPDGAGSCWRIRSVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG3</accession>
    <name>R4WAG3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-FPG_IleRS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="58" mass="6492" checksum="6153A16C0288CD9C" modified="2013-07-24" version="1">MECPRCGGEIETYSLAGHDADICESCGYVGVAVEHQSEPEEFESWTDALERFYEEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VSJ3</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN00175">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AGN00175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="301" mass="33090" checksum="4548BEBD9CBEDB19" modified="2013-07-24" version="1">MSQHDSVDADDGMLQCVDCVDPAEAFSVIGNDTRLSILEALWQTDADAVSFSDLRRDVGMRDSAQFNYHLGQLTDHFVRKVEDGYELQHAGEKVVTAVIAGSITEKPDVEPFPVEGECFACGSALQGVYEDERLAIECVDCGHKHGDYDFPPGGLTDRTPAEIADAFDQRVRHLHCLSADGVCPECSGRMTHTIEQGGDCCLGIPVRVEHECEQCGHELCSAPGLRLLDHSAVVSFHRERGVHLDEQPYWTLPWCVGSEPTELVSEDPVRIELVAAIDGDELHVTMDGDLDVIETEVREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VTL6</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="276" mass="29526" checksum="91C3BF2681E55212" modified="2013-07-24" version="1">MTDSQRRQFLVGVGGLGAATLAGCSGILGDGSGNSGGSIPAYADWVPATVRTENWEYGVSAVDVDRFKRELPAARSSRFRSDVSSFAQALGVEESRFDTVVQIEEAEQPTHTIITGSFDVDAIQSRLESSFENEAYRGYRVLGIRLAISQDAIVSSTSFEDVIDAKEGVVDRIYERPNAWSDALRDAGTATLSSVSRHSGEPYQLLATAITSPDGDALDVVGHAHFPDAEAANTYSAEVGPAMEEHGEDVGPLEIRTVQTNGAVVRVEARATSYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUA5</accession>
    <name>R4VUA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">L593_04145</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04145"/>
    <dbReference type="EnsemblBacteria" id="AGN00780">
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        <property type="gene ID" value="L593_04145"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04145"/>
    <dbReference type="eggNOG" id="arCOG04795">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="51" mass="5830" checksum="BCE217C35C6ACD49" modified="2013-07-24" version="1">MPPTQEVACENDDCFLDMFENHYTYDVPEDYGIDELACPVCQGTDLRAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUF6</accession>
    <name>R4VUF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_04445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445734.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04445"/>
    <dbReference type="EnsemblBacteria" id="AGN00840">
        <property type="protein sequence ID" value="AGN00840"/>
        <property type="gene ID" value="L593_04445"/>
    </dbReference>
    <dbReference type="GeneID" id="16180941"/>
    <dbReference type="KEGG" id="sali:L593_04445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.906"/>
    <dbReference type="eggNOG" id="arCOG02333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_58_2"/>
    <dbReference type="OrthoDB" id="16486at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="287"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="514" mass="56370" checksum="D081D65D16E3B086" modified="2013-07-24" version="1">MVVETAATFEALVDVYAGAVFVVDREGRYREVIEGSEGSDVLYDLPESLTGQEFRDVLPPETAERFHRVVREAIDSGTPSIVEYELEVQAGHRWFEATVSPIEDEELVVWAARDVTERKQYERALAALHEAGPRLTASDSVADVCEEAIYAAETILDFDQSMIALERDGVLQAEATSEQLPADATTTVPIDDGIAGRTYRTGESYLTPDLAETDAALDHVEFRAGLSVPIGDHGVFQAVAERPDAFDETDLELAELFVGQVDATITRLEHERALERQNERLDEFASIVSHDLRNPLTVANGRLELAAEECDSEHLEHVADAHDRMQGLIDDLLTLAQSGEDVAVEPVDLAHLVRECWQLIETEDATLDVAVERPIEANRTQLRQLLENLLGNAVEHGSTGPGSQARQDAVEHGSTSPRSQAHEDAVEHGDDGVTITVGDLEDGFYVEDDGPGIDDVDRDRLFEAGYSSADGGTGIGLHIVGSVAERHGWTVELDEEYEDGARFEITGVERPDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUI8</accession>
    <name>R4VUI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid-binding protein, PBP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_04655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445774.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04655"/>
    <dbReference type="EnsemblBacteria" id="AGN00880">
        <property type="protein sequence ID" value="AGN00880"/>
        <property type="gene ID" value="L593_04655"/>
    </dbReference>
    <dbReference type="GeneID" id="16181042"/>
    <dbReference type="KEGG" id="sali:L593_04655"/>
    <dbReference type="eggNOG" id="arCOG04702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_2_2"/>
    <dbReference type="OrthoDB" id="98388at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="150" mass="16354" checksum="A3D213C90CF911E3" modified="2013-07-24" version="1">MSELTLTSPAFADGEPIPDEYGYEARNVNPPLRIEGAPDAAESIVLLMDDPDAVEPAGKVWDHWTVFDLDPELTEIPEDWDVEGTEGRNDYGEVGYGGPNPPDGEHTYRFRVYALDRSLDTAGVETKDAVEAAMDGHVLAQDTLTGTYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VUU7</accession>
    <name>R4VUU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444935.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00430"/>
    <dbReference type="EnsemblBacteria" id="AGN00041">
        <property type="protein sequence ID" value="AGN00041"/>
        <property type="gene ID" value="L593_00430"/>
    </dbReference>
    <dbReference type="GeneID" id="16181540"/>
    <dbReference type="KEGG" id="sali:L593_00430"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04505">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730791_0_0_2"/>
    <dbReference type="OrthoDB" id="64312at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="378" mass="41910" checksum="BA9CC7D9CEFFF316" modified="2013-07-24" version="1">MVPTVLHVSDTLAFAPDSPDEPEVDLGGLANVVRRAIDRDVDAVVHTGNLLRSPEPKPDTIQAIRSALTTLRDAEIPVYLVAGTRESTGDGTAIEEFRDGDLAHELGTSPVRIDDLALYGVDHVDSGDAFQRELAALEPTEDYAYNVIACHQGIWPPLDEADADVSAFDAMVATDVFVDDVLAGGSDEPLAWENDDFDYCVTYAGSTNRRHREDGAIPTGTLIEASTDAHSHERIPLTATEPEQEIERLRTTLDHQPADLESADVETLADLYGLAARARELFDQRRREIREELLDRVHEDMRIQGTYAAVTRTTSQRRVTKPQREVFEALRQAGVNPYEVLELDSSALRELSEAGRVSDEDVFDREERTYVRVSDTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4VV22</accession>
    <name>R4VV22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation inhibitor, yjgF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_05705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05705"/>
    <dbReference type="EnsemblBacteria" id="AGN01090">
        <property type="protein sequence ID" value="AGN01090"/>
        <property type="gene ID" value="L593_05705"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05705"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_4_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="138" mass="14938" checksum="9A16F4DAA17CE0A9" modified="2013-07-24" version="1">MEAEPMQQPSPDRASAPDRQQRDGTAFVGAFGKTTGESDLCFVEGQLPEDGDGVVDDPPAKQLERCLQNLDAQLDRHGRDPSDVLQLTLYLTDLDAYEEVNDAYEAYFDDTYPARTTVGVSELLGGAAVTVDAVVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVQ3</accession>
    <name>R4VVQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase or acyltransferase of alpha/beta superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446174.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06665"/>
    <dbReference type="EnsemblBacteria" id="AGN01280">
        <property type="protein sequence ID" value="AGN01280"/>
        <property type="gene ID" value="L593_06665"/>
    </dbReference>
    <dbReference type="GeneID" id="16181837"/>
    <dbReference type="KEGG" id="sali:L593_06665"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1361"/>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_2"/>
    <dbReference type="OrthoDB" id="35407at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="295" mass="31878" checksum="2D4CCE02398545EF" modified="2013-07-24" version="1">MPTAHNGDVGIHYELDGPDDGEPVVLLEGLGYGRWMWRWQRERLNDEYRVVLPDNRGTGDSDVPEGPYSMADMAADLEAVLADVEAADGTAGLDAVHVVGASMGGMIAQQYAFDYDRAATLTLLCTSHGGEESVPIPEDTAQQILEVPEGYDERETIKHRMEPAVSDGFYEANPDLVESIVDWRLAGDATEAGRNAQAAAVQAFDVSDRVDEIELPVRLLHGDADRVVPVENGRMLDEKLPNAELVEVEDGPHLFFVEQPDLAGERTREHLEANPIETDAEGGAADADSSAAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVU1</accession>
    <name>R4VVU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Halocyanin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_02125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AGN00376">
        <property type="protein sequence ID" value="AGN00376"/>
        <property type="gene ID" value="L593_02125"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02125"/>
    <dbReference type="eggNOG" id="arCOG02921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017533">
        <property type="entry name" value="Halocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002387">
        <property type="entry name" value="Plastocyanin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00157">
        <property type="entry name" value="PLASTOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03102">
        <property type="entry name" value="halo_cynanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Copper-bind" evidence="5">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15073" checksum="E00A355D3A6468E7" modified="2013-07-24" version="1">MLAATGSAVAAALAGCLGGGGPSATSDDWEYLEDGPDYGGWFDDTGNFEGTVDWTGRDSVTIDVGAGDDGRLFAPPAVRVDAGTTITWEWSGAGGPHNVVAEDGSFDSGSSTASGDATYEYTPESTGTYRYVCVPHESMGMVGAVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVU8</accession>
    <name>R4VVU8_9EURY</name>
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        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain-containing protein region/nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L593_06915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06915"/>
    <dbReference type="EnsemblBacteria" id="AGN01330">
        <property type="protein sequence ID" value="AGN01330"/>
        <property type="gene ID" value="L593_06915"/>
    </dbReference>
    <dbReference type="GeneID" id="16179899"/>
    <dbReference type="KEGG" id="sali:L593_06915"/>
    <dbReference type="eggNOG" id="arCOG01208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105300_0_0_2"/>
    <dbReference type="OrthoDB" id="67315at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
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    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="228" mass="25367" checksum="03332320037BDB8B" modified="2013-07-24" version="1">MSRDTGADAERGLSVTLPVPLPDDSLFGLASTDAVIEYLARNRTESIAQTDLADRIDSPESSVQRAVDVLAANDLVEVRYEGNRKLVRINRSRLDVPDDPYLEIPQAEFQAPVRAAVGRLRSELDQVVGIVLYGSVANGTADRRSDVDLWVVVRSNRAANQRAANEIVADLEAQRFDGERYAFHVAVESTESLPAFTEDVRAILRAGIVLHETDEYQQLHELLRREQE</sequence>
</entry>
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    <accession>R4VVW9</accession>
    <name>R4VVW9_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446249.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01355">
        <property type="protein sequence ID" value="AGN01355"/>
        <property type="gene ID" value="L593_07040"/>
    </dbReference>
    <dbReference type="GeneID" id="16182290"/>
    <dbReference type="KEGG" id="sali:L593_07040"/>
    <dbReference type="eggNOG" id="arCOG11843">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490595_0_0_2"/>
    <dbReference type="OrthoDB" id="127203at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="86" mass="9389" checksum="AD7E8248172C78BD" modified="2013-07-24" version="1">MGVVQRVRNVLSGERNRERSGATDRDQSGDPDLRGPESDDGTDTRTTNLYHCEPCGTTYVSDDLDACSQCGNSLERVPTEQDLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVX4</accession>
    <name>R4VVX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_07065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07065"/>
    <dbReference type="EnsemblBacteria" id="AGN01360">
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        <property type="gene ID" value="L593_07065"/>
    </dbReference>
    <dbReference type="GeneID" id="16181995"/>
    <dbReference type="KEGG" id="sali:L593_07065"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1444"/>
    <dbReference type="eggNOG" id="arCOG02068">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151801_0_0_2"/>
    <dbReference type="OrthoDB" id="106244at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="107" mass="11828" checksum="C6E65438DE58DF97" modified="2013-07-24" version="1">MHLGIILETNDPERVWNAFRLANTALDADHEVEVFLLGDGVEAPDLEAETFNPHGVMVKYDRAGGELFACGTCMESREIEPDDLRPHSTMGDCLRIVEDADEVLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4VW64</accession>
    <name>R4VW64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin-binding A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_02800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445405.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02800"/>
    <dbReference type="EnsemblBacteria" id="AGN00511">
        <property type="protein sequence ID" value="AGN00511"/>
        <property type="gene ID" value="L593_02800"/>
    </dbReference>
    <dbReference type="GeneID" id="16180338"/>
    <dbReference type="KEGG" id="sali:L593_02800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.566"/>
    <dbReference type="eggNOG" id="arCOG01695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OrthoDB" id="69351at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="3">
        <location>
            <begin position="531"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="740" mass="81798" checksum="E9EB8AE1104AB704" modified="2013-07-24" version="1">MEPKRELASVDLRALVGELGGYEGAIVDKAYLYGDDLLRLRLRDHDRGRLELLIEVGEQKRIHMADPDLVPDAPGRPPNFAKMLRNRMSGATFEGIEQHGFDRILKLDFERTDSDTSIVAELFGDGNIAVLDENGSVVDSLETVRLHSRTVAPGSKYEYPEARVDPLSLSYEAFVEHMDASDTDVVRTLATQLDLGGEYAEELCARAGVEKELPIAEADDSVYEPVYDALQWLADALETAALDPRVYYADPEDGGGADAAGEGDGRQRGQPVDVTPVPLADHENLASEPHDSFNAAVDAYFHELESYEADAGGAAGEPDRPDFEGEIEKQERIIAQQQEAIAGFEQEAQSLRAAAEALYAQYDLVDELLSTVRAAREEGHDWDAVEERLDEGAERGIEAAEIVASVDPQNARIRVELETGEGDDAETHTAWIEAEEGVEHNADRLYTEAKAVEEKKEGAESAIEDTRERLAEIEQRREEWEARDEQEDGAEAGDGSGGAEDGDEDGGRSDQEWLDLPSIPIRSRDWWYDRFRWFRTSQGFLVIGGRDADQNEELVQKYLEPGDRFLHAQAHGGPVTILKAADPSESGRDVEIPEAAEREAARFAVTYSSVWKEGKFSGDVYAVDHDQVSKTPESGEYLEKGGFAIRGDRTYYDDVEVACTVGIQCEPETRVIGGPPEAIEDQAVTTVAVEPGKFAQGDVGKRIYRQFRERFSDTSFVRKVASPDLIQHFLPPGTSRIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWA0</accession>
    <name>R4VWA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_07800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446399.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07800"/>
    <dbReference type="EnsemblBacteria" id="AGN01505">
        <property type="protein sequence ID" value="AGN01505"/>
        <property type="gene ID" value="L593_07800"/>
    </dbReference>
    <dbReference type="GeneID" id="16182274"/>
    <dbReference type="KEGG" id="sali:L593_07800"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1598"/>
    <dbReference type="eggNOG" id="arCOG01127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568173_0_0_2"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="440" mass="46251" checksum="36CDE940C4F5ECD5" modified="2013-07-24" version="1">MDEVAVVTAFLRHDGEVLACHRSEDAPTYPGQWGGVSGVIEDGEDPDQAARREASEEVGATGLMLVRSAESLRVRAPEYEAVFVVHPVLFDAPDRELTLSDELQAAEWVPATELLRRDTVPRLFETYQRVAPTVQSVAADDEHGAATLSIRALEVLRDRAGLLATEEDADLDELRYLGDRLREARPSMAVLRNRVNRALAAAGLVEPTERSGDTGNEGSAPEDVEQAAVDGINRALAADAEAAMRAAGLLSGWHVLTLSRSGTVFDALAADTVSAISIAESRPAREGIDVAEALASGSGESSTDSDGIEAPITVHTDAAIAHRLAVADVDAVVVGADAILPDGRVVNKTGTRGAAIAAAREDVPVYVAAATDKVTTREQVNLESGHPSAIYDGDAPLDVANPTFDVTPADAITGIVTERGVLDVEAIAEVAAELRELEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWD6</accession>
    <name>R4VWD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_08025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446444.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08025"/>
    <dbReference type="EnsemblBacteria" id="AGN01550">
        <property type="protein sequence ID" value="AGN01550"/>
        <property type="gene ID" value="L593_08025"/>
    </dbReference>
    <dbReference type="GeneID" id="16182284"/>
    <dbReference type="KEGG" id="sali:L593_08025"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1644"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="598" mass="63514" checksum="3C397D799B3411C4" modified="2013-07-24" version="1">MSDGTCDGLRTLLIGIDGASHEVLAERGESVVPNLTALLDRGSSGALESQIPPWTPSAWPSLYTGVNPGKHGVYGFLAFEGYDWDVVDYADVKAHALWELLSERGFTSVVVNVPVTHPPTAFDGALVPGYTSPESPTCHPSGLLADLEAELGDYRVYDDSTDPSDDRAERIESYERLLASRGEAFRYLADRFDPDFGFLQFQQTDTVFHESPEDDRVVDAVYAAADREIGATIEACDPDVVLVASDHGIGPYDGHEFRANSFLRDRGDVATTVGEGGMPSWTSIARNRLQGDPAGGAGDADGSADASGNSAANGTAGATALERSLAVAARVGVTSQRIERVVKRLGIEDLVLRIAPADAVRAAAEQVDFPASRAYVRDRIELGVRINLEGREPEGVVPPAEYDAVRSELVDALSAVETPDGEPVFEAVRPREAVFDGPYLEDAPDVVVVPNEFDQFLSASLHDEQFGPPSEPWNHKLDGLIAVAGDVDTSVSLADRFRATADGSRTAADSPAAGDGSPTGDTHREAAHLFDVAPTVLATFGLPAAERMDGDVLPVVEPAGVERYPDYDPAADGPAGAPAATEESAVEDRLADLGYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWG0</accession>
    <name>R4VWG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_08175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446474.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08175"/>
    <dbReference type="EnsemblBacteria" id="AGN01580">
        <property type="protein sequence ID" value="AGN01580"/>
        <property type="gene ID" value="L593_08175"/>
    </dbReference>
    <dbReference type="GeneID" id="16180009"/>
    <dbReference type="KEGG" id="sali:L593_08175"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1677"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_2"/>
    <dbReference type="OrthoDB" id="44471at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="346" mass="36411" checksum="E56D6A6846AFDBFB" modified="2013-07-24" version="1">MIDLRSDTVTTPSNAMRDAARDADVGDDVYGEDPTVNELEAAVADRLGFEAAVFVPTGTMGNQIAIRTHTEPGQEILVDREAHVFNWEVGGLALHSGLQTRPFEETVRRDGRERGVPTPEAIESGYVEESVHRAGTGLVSLENTHNGRGGLAIAPERIDAAAEAAHDLGVPVHLDGARLFNAAVAHDVPAERFTRQVDSAMVCLSKGLGAPIGSMLAGSAEFVEAARRNRKLLGGGMRQAGIVAAPGLLALDSVDRLADDHRNADRLAVGLADLPGLDVVAPETNIVLVDVSDAAQDAAAFKQACADAGVACTTMDETTARFCTHRNVDKADVDEALSLVADVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VWR6</accession>
    <name>R4VWR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445590.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00696">
        <property type="protein sequence ID" value="AGN00696"/>
        <property type="gene ID" value="L593_03725"/>
    </dbReference>
    <dbReference type="GeneID" id="16180767"/>
    <dbReference type="KEGG" id="sali:L593_03725"/>
    <dbReference type="eggNOG" id="arCOG02600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OrthoDB" id="102459at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="129" mass="14384" checksum="CE78E9E3B1C4D391" modified="2013-07-24" version="1">MTDGSGGTVDAPERLEVWCAGEHWCPVTTTATLIGKKWHPVIVHRLLDAGPSGFSELQNHVDGISSKVLSESLEDLEERSLVDRTVVSEKPFRVEYELTEHGASLEPVIEAMREWGNEHLRPPAEDERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX46</accession>
    <name>R4VX46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01795">
        <property type="protein sequence ID" value="AGN01795"/>
        <property type="gene ID" value="L593_09250"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_09250"/>
    <dbReference type="eggNOG" id="arCOG09270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_213599_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="52" mass="5560" checksum="75FA767D590D745A" modified="2013-07-24" version="1">MSAPAAEPATLVCHACRFSAPAGDEWDKIEVTGVGTMTRCPKCGSTRVEHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R4VX74</accession>
    <name>R4VX74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446724.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01830">
        <property type="protein sequence ID" value="AGN01830"/>
        <property type="gene ID" value="L593_09425"/>
    </dbReference>
    <dbReference type="GeneID" id="16182796"/>
    <dbReference type="KEGG" id="sali:L593_09425"/>
    <dbReference type="HOGENOM" id="CLU_982178_0_0_2"/>
    <dbReference type="OrthoDB" id="113944at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="283" mass="29932" checksum="5CCCAAE9C6E76160" modified="2013-07-24" version="1">MVAPSDGVRLDDGDWERAFERLDEQGGGVIRVPTGVTASEPARIDLADYPNLQNNVSIRGSGLAASVVDFGEGPGDGLSLVATDSDVDDGDDRTHVFYTEITGVGFQGARDGVLFRLGSDDFADAWNSCDLHLATNNGSPDATAACRLNFVLNSRHFGVHNTTGGVALDQRQVQFGGLNGAVSSKQGVSLRLGGGSFANVIEWLNVEACEDGVLIDGDEANINRFGMLYGANVDGTLWRHEAPVETRIDAAYVAGAVETIDRCTEGSYSVGLSNEPFATAIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXE9</accession>
    <name>R4VXE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_09875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446814.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01920">
        <property type="protein sequence ID" value="AGN01920"/>
        <property type="gene ID" value="L593_09875"/>
    </dbReference>
    <dbReference type="GeneID" id="16182843"/>
    <dbReference type="KEGG" id="sali:L593_09875"/>
    <dbReference type="eggNOG" id="arCOG02980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627930_0_0_2"/>
    <dbReference type="OrthoDB" id="85911at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="436" mass="46800" checksum="358FFCB7B679E14A" modified="2013-07-24" version="1">MRPSRLLAGLLAFTLVVLTIGVAFPPTTPADVGGSQSYVDDPVAVEGGEIDADQTALWGWTQRAMGQNVDATPTVVIRDFGDVGGGTAVQTEATEFQWLMIYDDPDEQPPGGFLAYVTAFSTDVNVNAARLPAVRNGTTGRTVEGLLVHEFAHVVQFQTPAFAENQLSPLSATTDEITAYTAMVEGGAELVADAYTNDSAVERVRQYWNDPRTSAAARFGQWPYYRGLVYLDQRLDDPQQLWGIYEDRPQTTATILRGDAPGDGPPNRTLSLALEDYHSEVRDRPGAMLAEVALTREVDPERARDVAAGWQWGALRSIQPDRGTDADRSLRHVWVTECRNESAADAFESAMTEYLDGRWEATNGTWNAGDGRSFDLIRVNDDSLAVLVGPEAFLAGTTVTASGDEYSIVEPTGEFTSVAGPSSAPAAGVAAASAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXL4</accession>
    <name>R4VXL4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="11">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaA</name>
        <name evidence="14" type="ORF">L593_05260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="11"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05260"/>
    <dbReference type="EnsemblBacteria" id="AGN01001">
        <property type="protein sequence ID" value="AGN01001"/>
        <property type="gene ID" value="L593_05260"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05260"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1074"/>
    <dbReference type="eggNOG" id="arCOG00930">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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            <end position="233"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="41932" checksum="284BA6569A6474BB" modified="2013-07-24" version="1">MLEDEFGREVSGVRVSLTDRCNFDCVYCHNEGLGDVRGPMEPTDEELGTDEVVRFLEVAAEFDVEAVKFTGGEPLLRADLEEIVRRTPDSMAVSLTTNGTMLPDRAAALAAAGVGRVNVSQDAIDPDAFAAVTNSGAYDRVIEGVEAALDAGLAPVKLNMVVFEATAGHVPAMVEHVAANDGLQLQLIEYMPEIAGNPEWAIDIERVHDWLAEQAHRVERREMHGRRRYFLREGATAAEVSEAAAGEPVAEVAADGGGAASRGGADAVPGEGMVEIVDPVANESFCANCHRVRLTHDGKLKGCLNRNDDLRSMGETKDEIRATFRETVANRVPYYGEYLVKADAEGDDGEGSGVEAAGSGADGESSEANAASSGTDATGSGVDAEWVVNEAYLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4VXP0</accession>
    <name>R4VXP0_9EURY</name>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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            <begin position="4"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02025.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
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    </evidence>
    <sequence length="345" mass="36263" checksum="FF2DBA8C359C2ACF" modified="2013-07-24" version="1">MSVRVGVIGATGAVGQRLIQQLAPHDDFEIAALTASESSAGKPYSEAAKWRASGPIPDGVGDVTVVETDPSAVGDDVDLLFSSLPSSVGERVEPAFAEAGYVVSSNSSNGRLDDDVPLVIPEVNADHVDLIEVQRDERGWDGALLKNPNCSTITMVPPLAALDDAFGLESVTVSTLQAVSGAGYDGVTSMEIIDNVLPHIGGEETKMETETCKLLGGFDGAELSWHDVEVSASCNRVPTLDGHLENVWAETAEDAGPAEAEQAFRDMPSVDLPSAPEQLIHVHEDPNRPQPRLDRDAEGGQAISVGPVQETPDGILFDSLAHNTIRGAAGASVLNGELLLERGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VY84</accession>
    <name>R4VY84_9EURY</name>
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        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">L593_11300</name>
    </gene>
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    </organism>
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        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
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            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="sali:L593_11300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2331"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="26292at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="333" mass="36866" checksum="160191A5AD2A7C8E" modified="2013-07-24" version="1">MDLHRLTLDEWADALPSGGFEPFHHPDALSALEAHSQGELRCYGGFKGQQPVALLPAIVQDRSVGRAILSPPPGKGIPRLGPVLDPASPKQRKREKVNRTFAELVLDDLAIDGRGTLFRMTCNADYVDPRPYVWSDLELDTSFTYRLDTDGEAPGAIRKNFSKSLRREIGDAEDLPVTVEREGIDGAEAIYEDTRRRYNEQDRPFRLSWPYVGDLFTGLGDRARAYVVRGPDGEFLSGITALYSNDAAYYWQGGARATFDGTAVNSLVHWRILEDLATNAPHGATTYDLMGANTERLCRYKSKFGAELVPYYVVESGGAGMDVAKKAYSLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYD8</accession>
    <name>R4VYD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YgbK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_06445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06445"/>
    <dbReference type="EnsemblBacteria" id="AGN01236">
        <property type="protein sequence ID" value="AGN01236"/>
        <property type="gene ID" value="L593_06445"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_06445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1313"/>
    <dbReference type="eggNOG" id="arCOG08629">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029424_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="245"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="423" mass="42691" checksum="AC9690F46053CD28" modified="2013-07-24" version="1">MGSPPGLTVSYLVVADDLTGANDTGAAFAATGQETVIEIEGGGDGREDASDAAVRVVNTDSRYSDPATAAERVRSAVERAPDADVYKKVDSTLRGNLVAEIDAAMAASGADLAIVAPAFPATGRITVGGYHLVEETPVAETAAGRDAKGPTTSHVPTLLEASSYPVVHRSLDDLGESVALRASFEELAASGDGALVVADATTDEHLERVADAAAAAREAAGIDVLFVGSGGLAAHVGSGGSSAVLGVVGSVAPETFEQLEAVPDDQVVLLDSELVVTEPAAAVADAAEALGQRLDDDQPAVVTAATDREDVEATLAAGRATGLDDEEIRDHVAEALGKTALTVERDHGIDGLFATGGAVATATFDAFDAMGVRLTGHQVEAGIPLGRIQGGRADGLAVVTKAGAFGGETAIVNGLRFLARYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYG4</accession>
    <name>R4VYG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446160.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06595"/>
    <dbReference type="EnsemblBacteria" id="AGN01266">
        <property type="protein sequence ID" value="AGN01266"/>
        <property type="gene ID" value="L593_06595"/>
    </dbReference>
    <dbReference type="GeneID" id="16181769"/>
    <dbReference type="KEGG" id="sali:L593_06595"/>
    <dbReference type="eggNOG" id="arCOG07779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176022_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="73" mass="7235" checksum="2A15B3A235D56C44" modified="2013-07-24" version="1">MALTPNVGKTDRIVRGIVGALLLVAAAVTFSSGSTALAAVAGVVGVVLLVTAATQFCGLYRVLGMSTCPADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYH6</accession>
    <name>R4VYH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_06670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446175.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06670"/>
    <dbReference type="EnsemblBacteria" id="AGN01281">
        <property type="protein sequence ID" value="AGN01281"/>
        <property type="gene ID" value="L593_06670"/>
    </dbReference>
    <dbReference type="GeneID" id="16181843"/>
    <dbReference type="KEGG" id="sali:L593_06670"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1362"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_2"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="481"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="572" mass="61176" checksum="ED47F4EF7496AF89" modified="2013-07-24" version="1">MDWNARPYEWVGDWSARRRSLSPDREAIVDATTGERYTYADLDRRGNRTARLLEDHGVTAADDDPVTDDTGENAPGADAGGERVAVVSRNRIEVFDLFFATGKTGGVLAPLSHRLAPRELGELLELVDPRLLVVEEPFAERVADALDAAAVDPPVLGLPDDTAGDVASAPDSEFGSLAAADYGEALPADDSPVETAAVALDDPHLLLHTGGSTGTPKETIVTHGSIAWNSFNTIASWGLRPDDVTPMVFPTFHTGGWNVISIPLFHMGGTIVIDREVEPGRVLEQIESESATLLVAVPAVLRMMADHDDWAETDLSSLRFVKSGGGPCRESVIRAWRERDGPTDGDDGVDLSQGYGLTECGPNNFAMPDGWADGPEEQVRDRVASVGKPALHVDARVVGEDGEPLPDGEIGELELAGQHAAAGYWRNPEETEAAFGEAPDGQRWVSTGDLARVDDDGFVSIEGRKKNMFVSGGENVYPPAVEDAIAEHPDVGDVIVIGIDDETWGTVGKAVVEPAAGVDGEPFDLAALEAFLEDRLARFEVPRALAFVEELPTSGPSKIDRQAVEERFGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4VYN5</accession>
    <name>R4VYN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_06995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446240.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06995"/>
    <dbReference type="EnsemblBacteria" id="AGN01346">
        <property type="protein sequence ID" value="AGN01346"/>
        <property type="gene ID" value="L593_06995"/>
    </dbReference>
    <dbReference type="GeneID" id="16181960"/>
    <dbReference type="KEGG" id="sali:L593_06995"/>
    <dbReference type="eggNOG" id="arCOG10300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190392_0_0_2"/>
    <dbReference type="OrthoDB" id="119903at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="64" mass="6952" checksum="87547C89079E0AB5" modified="2013-07-24" version="1">MDAVVNETTKTVHRRADETASKETACGATSHVDPEHLSRTSLERARSAHEASKCGRCFEDGGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ11</accession>
    <name>R4VZ11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446380.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07705"/>
    <dbReference type="EnsemblBacteria" id="AGN01486">
        <property type="protein sequence ID" value="AGN01486"/>
        <property type="gene ID" value="L593_07705"/>
    </dbReference>
    <dbReference type="GeneID" id="16182195"/>
    <dbReference type="KEGG" id="sali:L593_07705"/>
    <dbReference type="eggNOG" id="arCOG06386">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176022_2_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="70" mass="6772" checksum="A417AE4412C77AE8" modified="2013-07-24" version="1">MNKNVGGLDRSGRIVVGIIAVVAGVAAFAGSLAVGAVIGAVALLVGAILLVTGTTQRCPINQAAGIDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZ86</accession>
    <name>R4VZ86_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_08105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446460.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_08105"/>
    <dbReference type="EnsemblBacteria" id="AGN01566">
        <property type="protein sequence ID" value="AGN01566"/>
        <property type="gene ID" value="L593_08105"/>
    </dbReference>
    <dbReference type="GeneID" id="16182306"/>
    <dbReference type="KEGG" id="sali:L593_08105"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1661"/>
    <dbReference type="eggNOG" id="arCOG06334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686282_0_0_2"/>
    <dbReference type="OrthoDB" id="50264at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="401" mass="40225" checksum="3DFCE6C1CCBA349D" modified="2013-07-24" version="1">MYSRLALVACALALVAVPAIVLAGGAGSADGGPGTAAATVDTPNGSIISLSPATGPNGQYASVNGDDELELAFGDLNRNATTTADSVFVINVTAASPVALRIEDDAPGVGFYWAGDPAANANESRTVQPGQSVAVGVRADSVGAIDDGNFTVVAEEPSQTGGGGGGFYVPPEDDGDLTVVDADVSPPEIAVGESATATATVVNGGDSTASGTVELVIDGTVVDQQTVTVAGDGSETVSFDRTFQQTGEFAVAVDGLDAGTVTVSAGAEASGFSVANASLSPSVIQPGDATTITANVTNHDGAAAFFRAELSVGGVVVEQRPVRIGPGETVQVSFERTFDRRGGYEIVIGGTEAGTLRVEDSATTSMRRYGSEYGWLLGAATVPTIGGAFVAARRRRQVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VZN8</accession>
    <name>R4VZN8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447604.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13855"/>
    <dbReference type="EnsemblBacteria" id="AGN02710">
        <property type="protein sequence ID" value="AGN02710"/>
        <property type="gene ID" value="L593_13855"/>
    </dbReference>
    <dbReference type="GeneID" id="16180889"/>
    <dbReference type="KEGG" id="sali:L593_13855"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_0_0_2"/>
    <dbReference type="OrthoDB" id="96038at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="140" mass="15420" checksum="08432112C59B634E" modified="2013-07-24" version="1">MCGGIRAHLRMCGHDTVYALDRGIETDEEILALAHDEGRTIVSRDRDLVVRADDAILLESTDATEQLATLASEGIELQLSEEPTRCGRCNGRLGRIDPSDTTPSHVPDAAKMAVWQCRDCGQCFWKGSHWERVAATLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0B6</accession>
    <name>R4W0B6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446825.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09930"/>
    <dbReference type="EnsemblBacteria" id="AGN01931">
        <property type="protein sequence ID" value="AGN01931"/>
        <property type="gene ID" value="L593_09930"/>
    </dbReference>
    <dbReference type="GeneID" id="16182627"/>
    <dbReference type="KEGG" id="sali:L593_09930"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2046"/>
    <dbReference type="eggNOG" id="arCOG04300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="OrthoDB" id="31182at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="329" mass="35542" checksum="E749941A6E120FF1" modified="2013-07-24" version="1">MHPTERPRRLRRDGLRELVAETALDASDMVAPVFVDATADERVPIESMPGHERVPIAEAVPRVEEVLETGVEAVMLFGIPESKDAEGSRAWAEDGVIQRATRAITRETDATVITDVCLCEYTDHGHCGVLESGAGEPDGEADLTVANDPTLDLLGKIATSHAEAGADVVAPSGMIDGMVGAIREALDADGHDSVPILSYAAKYESAFYGPFRDAADGAPAFGDRRHYQMDPANGEEAEREVRLDVEQGADILMVKPALPYLDVVRRVDEEFDRPVAAYNVSGEYAMLHAAADRGWLDLEDVAAESLLSIKRAGADLIVTYFAEDVARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0C0</accession>
    <name>R4W0C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L593_09955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446830.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09955"/>
    <dbReference type="EnsemblBacteria" id="AGN01936">
        <property type="protein sequence ID" value="AGN01936"/>
        <property type="gene ID" value="L593_09955"/>
    </dbReference>
    <dbReference type="GeneID" id="16181323"/>
    <dbReference type="KEGG" id="sali:L593_09955"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2051"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_2"/>
    <dbReference type="OrthoDB" id="66605at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="11">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="8">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AGN01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="562" mass="58249" checksum="B67CEF0353164090" modified="2013-07-24" version="1">MVGAMPLQIGAETAGAINYTWILVVSFLIFFMHAGFAMLEAGQVRSKNVANQLTKNLLTWSVGVLAFLLVGAGLAPLVGDLVGSTGGWSFTPNNSPASWGTGWFYGAVFAMTAATIVSGAVAGRAKLRAYVTYTIALAAVIYPVVLAFTWSGYWVNEFLGTFFQDFAGGMIVHGMGGIAGLTAAWVLGPRMDRYNEDGSVNVIPGHSLTFAVLGTLLLAFGWYGFNVGTASVVVQEGGEWVLNGDTLGRVVLTTTVAMAMGAIGAGSVAWAKTGKVDTLYVANGLLAGLVGITAIPNVATWWGAFVVGGLAGAQLPLVFGFVEKTLKIDDVCAVFPVHGSAGVLGTLLYPFVATDAALGGTSIADAFVAQFLGVAMITVWTVAATAAVWGGLKAIGQARVTPAHEREGLDVAEHGVDTYPEFGKPDVATDGGAPVPEEQLRTDGGSFATDIEMVMAVVRPDKLGDVKKALAEVGAPSLTVTNVSGRGSQPAKKGQWRGEEYTVDLHQKVKIECIVSDVPAEDVVDAIRDGANTGEPGDGKVFVLPVTQATQIRTGATGPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0K2</accession>
    <name>R4W0K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cdc6-related protein AAA superfamily ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_10555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446950.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10555"/>
    <dbReference type="EnsemblBacteria" id="AGN02056">
        <property type="protein sequence ID" value="AGN02056"/>
        <property type="gene ID" value="L593_10555"/>
    </dbReference>
    <dbReference type="GeneID" id="16182417"/>
    <dbReference type="KEGG" id="sali:L593_10555"/>
    <dbReference type="eggNOG" id="arCOG00468">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059498_0_0_2"/>
    <dbReference type="OrthoDB" id="29429at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="396" mass="42509" checksum="D61AFB7B59A937B3" modified="2013-07-24" version="1">MDLSERIERRQMRTRDDRLLLDRSLLSPTVHLDEPVGRAPALESLLDAVEPVFEGRLPPTLAVAGPAGVGKSAVVGSLFRALDQRLGVGGSIATTTRGGSPQRSFATVDCRHAPTPFRFYRQLLCQLGDAEVPAHGVGTARLREEVIDQLGPQGRWAVIAVDHVAEAADLDPTSVRELLDPVADSVSLTWVGRSPPVDAERTVRIEPYRHHALTDVLAHRCSRAARTDAFDHDDLRTIAARKEGNAHDALAVALGAALLAEAAGDSAIDREHLTAASAAVPEGTVHLDAVLALPENRRRVLAELLRLDPAPTVGEAARDIADQTDLTAGTVRRFCYELSDAGVLARHGGDADARGRDPSHLTPAFPWLAFAGVDDVLSVADVRDRVEREAAPLATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W0N5</accession>
    <name>R4W0N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447000.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10805"/>
    <dbReference type="EnsemblBacteria" id="AGN02106">
        <property type="protein sequence ID" value="AGN02106"/>
        <property type="gene ID" value="L593_10805"/>
    </dbReference>
    <dbReference type="GeneID" id="16180755"/>
    <dbReference type="KEGG" id="sali:L593_10805"/>
    <dbReference type="eggNOG" id="arCOG02980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027187_0_0_2"/>
    <dbReference type="OrthoDB" id="11006at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="629" mass="65763" checksum="BAB4CF1F406B49EA" modified="2013-07-24" version="1">MRTGPTVAVALVGVLVVALVAGSGGATALESGTATADAGNNMAPSIESCAADSPEDFGAPAGGDAIGYVDGYWYDEPIVLPAADDGTVETNDTDPSGADTDDGGNETTVDTNGTDTDGNDTDEGGNETDAGTNETNGGGENATSNDSTDAKPTNSTNQFDATDGLNDRELEAVVARTAARVETVRCLSFASVPTVRLENRSTVRATQHDAIADRPVSAERFDDARLSTALLLGDATSANEARARTTASATLGYYDPATDSIVVVVDNGTASNVDEATLAHELVHALQTRHFELDRFDASRTDAALAESALIEGDASLVAHQYRIHCADGDWASDCFEGQSTAGTNSEYLGLQLLLYQPYNEGGAYAEALYAEGGWAAVNDRYDDPPTSTKELLYPTTSTAFEPATVSFQPVTDPAWQRVDPGGQSDFDVLGPGTIGAAMIAPTFDAETDNIYSAQHVTNNVDQSTLDPLEPYDYAVDATAGWEGGQLEVYSNEANQTAARWRTEWESATAAATFRERYVQLLDTRGAASSRNFVGTYHFPPEHGYDGRYAIRQNGSTVTIVQGPNLTAVRALDPLAAREPSEGSSSSMTSLGTSKRVAEDALSGPGGLGAAIGILVAIGLIGVVAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W139</accession>
    <name>R4W139_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5611 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447165.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11640"/>
    <dbReference type="EnsemblBacteria" id="AGN02271">
        <property type="protein sequence ID" value="AGN02271"/>
        <property type="gene ID" value="L593_11640"/>
    </dbReference>
    <dbReference type="GeneID" id="16181945"/>
    <dbReference type="KEGG" id="sali:L593_11640"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2399"/>
    <dbReference type="eggNOG" id="arCOG04690">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139544_0_0_2"/>
    <dbReference type="OrthoDB" id="100538at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040713">
        <property type="entry name" value="DUF5611"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18446">
        <property type="entry name" value="DUF5611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5611" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="128" mass="14744" checksum="C2244507CD554827" modified="2013-07-24" version="1">MKEYKMRRGEYLDERMPDLEGEIEEYFGPITTTESFKGNDLNVVEEPDNPVFERIVVGKTEYGSKKDKIAVEFHERDVADLGPEELEAAEEAVSLKNDFLEAATGRDAKSRRESLKRQVEDDPDHDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1P1</accession>
    <name>R4W1P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447445.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13060"/>
    <dbReference type="EnsemblBacteria" id="AGN02551">
        <property type="protein sequence ID" value="AGN02551"/>
        <property type="gene ID" value="L593_13060"/>
    </dbReference>
    <dbReference type="GeneID" id="16180369"/>
    <dbReference type="KEGG" id="sali:L593_13060"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OrthoDB" id="102459at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="114" mass="12759" checksum="0378BC6E45234080" modified="2013-07-24" version="1">MQADDDVAVDPQSCPTAETMDEIGTQWRLHVLHDLQDGELRFNELKEATGASSRTLSQSLDALMEAGLVERRTEEAAPIAVFYGLTEKGEDLEVVFDELDAWAEKWIDPSEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W1U3</accession>
    <name>R4W1U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447525.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13460"/>
    <dbReference type="EnsemblBacteria" id="AGN02631">
        <property type="protein sequence ID" value="AGN02631"/>
        <property type="gene ID" value="L593_13460"/>
    </dbReference>
    <dbReference type="GeneID" id="16180677"/>
    <dbReference type="KEGG" id="sali:L593_13460"/>
    <dbReference type="HOGENOM" id="CLU_2597908_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="79" mass="8024" checksum="0D62F6F4F5EE01EF" modified="2013-07-24" version="1">MIDALVDTALRPNRFQLAIVVTVGLSGGLASASVGASLPVIGLAILLGLVAGVLLTAYLTYIVPEGGASNRPGRRRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2E2</accession>
    <name>R4W2E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447740.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14535"/>
    <dbReference type="EnsemblBacteria" id="AGN02846">
        <property type="protein sequence ID" value="AGN02846"/>
        <property type="gene ID" value="L593_14535"/>
    </dbReference>
    <dbReference type="GeneID" id="16181316"/>
    <dbReference type="KEGG" id="sali:L593_14535"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2972"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109676_1_0_2"/>
    <dbReference type="OrthoDB" id="115607at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="173" mass="20149" checksum="AF6EBEDDF4919661" modified="2013-07-24" version="1">MADPDLELASRREIYQRIADTPGIHFRALLADLEYAQGTLQYQLRWLADEDLIDVSDDGKYTRYYPAAEFDEVDRTVMNALRREYSRRILAHLLTDGPLSTTELSDRLDKAQSTVSWHLSKLAEADLVTKERDGRSVVYEVSDPDRVKYLYTLHRRSFTDKVVDRILGLWDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2H2</accession>
    <name>R4W2H2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_00060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="JAB_dom_prok"/>
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    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGM99966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="182" mass="19922" checksum="54E3CBCB6736F7ED" modified="2013-07-24" version="1">MGLFDSLFRSSEILGIAEETLEFALEASEDAHPNEYMGFLRGTEASDLGLDRDGLVITDVLVIPGTTSNPVSATVKTNMIPNDRSAIGSVHSHPNGVLQPSAEDLATFTRGDVHIILGAPYRRTDWQAFDEEGQRRSLEVIDVALPEGEEFFHFDQADLDEQSGGTAHLDDAEFDARMGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R4W366</accession>
    <name>R4W366_9EURY</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000014072">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="123" mass="13055" checksum="5868D4561FD0CF30" modified="2013-07-24" version="1">MADLWGRDEPRRGDDDHAELLAELDSHDLRLSLDVAVHVAEDADFETVVYDGAASFGFVPLHRRARSASSLFGFLSVSVRGVASSAFGFVSIQTPSTVLRKAITSSWAAETASAIASGASSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W386</accession>
    <name>R4W386_9EURY</name>
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            <fullName evidence="3">RimK domain-containing protein ATP-grasp</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">L593_02130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="289" mass="31191" checksum="B60C0CE6E8C19BE2" modified="2013-07-24" version="1">MLRLAVATDAETFERLEEPLAARGIEVVHLQTKERTIGLTEPDARENAFAAADHDVGYVFPPRDVEGAVADAMLEIPWLVDHADVQTSRNKAEVLARCAAAGLPVPVTVLVSNPIDENRIREAVEQVGPPVVIKPTSTTRGVGVAKVGDADSALGVADYLDLVHDFAATGDKSFLVQSFVPDARDVRAMTIEGEYVGAVERERAGGWRHNVHRGAEATGIDLDPELRSLAEAVAQLLGIDLLGVDLLVTEDDAFVSETNARPTIDDASKYEPDFYDRLSSAIERTADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3Z5</accession>
    <name>R4W3Z5_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Natrialbaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04330"/>
    <dbReference type="EnsemblBacteria" id="AGN00817">
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    </dbReference>
    <dbReference type="GeneID" id="16180907"/>
    <dbReference type="KEGG" id="sali:L593_04330"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.881"/>
    <dbReference type="eggNOG" id="arCOG06306">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_0_2"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
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    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="303" mass="33656" checksum="B1D89D038D637DBE" modified="2013-07-24" version="1">METRPLGETGHDSSVLTFGAIALNFLEQDEANEMMQDVLDAGVNHVDVAPTYGDAELKLAPTLEDHRDEIFLGCKTQERTYYGAWGELHKSLDRLGVDKLDLYQFHAVTNYDELRAITGDYSPEMAQGDHDPGALQAFVEAKEEGLIDHIGLTSHGDPALIRSAIDRMPELETVMFPYNYTLAGKEGPEYDYDAVLEKAHEEGLGTLCIKGFAKGPWPDDVPEDERPYNTWYEPYDDPEELEECLRFSLSQGMTTIPNAGDPKLVPAILEAAQHYEALDDEAQDELRARGAGGDSPVPTTYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4F5</accession>
    <name>R4W4F5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_05740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
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            <taxon>Halobacteria</taxon>
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            <taxon>Natrialbaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
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                <person name="Sorokin D.Y."/>
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                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05740"/>
    <dbReference type="EnsemblBacteria" id="AGN01097">
        <property type="protein sequence ID" value="AGN01097"/>
        <property type="gene ID" value="L593_05740"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05740"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1175"/>
    <dbReference type="eggNOG" id="arCOG02408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100862_1_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="42"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="177" mass="18480" checksum="D837762A4E53CE21" modified="2013-07-24" version="1">MRWLRELLGATSNESRGDGSHDEDATAAEATGLETGAKTAPRVGLFVDGPNVLREDFSVDLDDARDAASEEGSLAISRCYLDENAPARLIQAAEARGFEVVVTSGDVDVRLAVDATAAIGDGAIDVLALASRDTDFKPVLEAARRAGIRTVALPPGQYGNSDALANAADVAVVLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4G1</accession>
    <name>R4W4G1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_05790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05790"/>
    <dbReference type="EnsemblBacteria" id="AGN01107">
        <property type="protein sequence ID" value="AGN01107"/>
        <property type="gene ID" value="L593_05790"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05790"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1185"/>
    <dbReference type="eggNOG" id="arCOG02899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507348_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN01107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="172" mass="19422" checksum="79DABE999321C861" modified="2013-07-24" version="1">MATDVYVEPERVYDLLVSFTEYAQYSEYLDEVTRHGDGSPGTEYELSFSWWRLAHTTRSRVTDVDPPNVINWRLVSRIAAQGRWEIEEAAEPIHGTASTGDPVTRVRFVVEYDPESADGDVLGLPALLSFDGLVDRVTPLIEDEATRVVERVVADLEGEPRDVELEVRHSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4H9</accession>
    <name>R4W4H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05940"/>
    <dbReference type="EnsemblBacteria" id="AGN01137">
        <property type="protein sequence ID" value="AGN01137"/>
        <property type="gene ID" value="L593_05940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1217"/>
    <dbReference type="eggNOG" id="arCOG00134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="435" mass="42910" checksum="D0032D34D79A4E8F" modified="2013-07-24" version="1">MVGTAASAHALVHAHELSIPILISVWLAEYSVTPALLGVVATVAYGFFGAGALPAGVLADRVGASRLIGASLLGAGGAFLLVGGAGWLPIDDVAPLGVPGPIWAIALALALWGVAASAYHPSGLTLLSTAVEQRGRGFALHGAAGNLGIATGPLVTILLLEVLAWQTVALVLGIGGIVVGATATILDVDTTVDAAGDSPVDDPDAEATPDGGESRDESAGDGATDSPSLRDELSTIRSVLGGPFLVVLAIVIASGLYYRGALTFLPEILADLEWLGPIDLGSRELPASRLVYVGVLAVGVVGQLIGGRLSDTLEPARGIAAAFLGLTALAVVFPIAAAAGAAPLLVVAALLGGALFVVQPLYQAAVAEFTPEAARGASYGLTYLCVFGIGALGGALAGGLLTIATAEALFLGLAGIAAVAALLAGGLATGRLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W4X9</accession>
    <name>R4W4X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbon starvation protein, predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L593_07250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446291.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07250"/>
    <dbReference type="EnsemblBacteria" id="AGN01397">
        <property type="protein sequence ID" value="AGN01397"/>
        <property type="gene ID" value="L593_07250"/>
    </dbReference>
    <dbReference type="GeneID" id="16182086"/>
    <dbReference type="KEGG" id="sali:L593_07250"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1480"/>
    <dbReference type="eggNOG" id="arCOG04286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010531_4_1_2"/>
    <dbReference type="OrthoDB" id="21159at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="8">
        <location>
            <begin position="5"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="9">
        <location>
            <begin position="430"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="631" mass="66533" checksum="9AE57FA4D23D69E6" modified="2013-07-24" version="1">MAGVIWIVALVLASFTVAYFTYGRYLSQFVELDDSRETPAHKYEDGQEYVPAKKPVLLGHHYSSIAGGAPIVGPITAAMIWGWVPAFLWVAIGNPLLGSVHDFTSLSSSLRHEGKSIGYIIGEYVGERGKDMLLWFAFLLIILVVAVFALVIGVAFNAYPSAAMASLIYVTLALLFGFWLYQFDLPFAAGTVLFVAGVFGSVWVGVNYPLALFGTQGAFATDESVIILLGDSAPSFLPKVLGSANIGAWLLVILVYGGVASVLPVWMLLQPRDYLSSFLLYTGVGGALLAVIVGTLITGVDATNPNTGAEITLNIQLDMWYGFMGDGGPFADTLPLMPLFPLLFVTIACGTISGFHSLVSSGTTAKQLDQETDAKLIGYGGMLGEGLLAAVSIATVAIIAIPAASGGIGLALPNFATGGGAILTALGVPMEYAAPFMALVLASFLLTSMDTACRLGRYMMEEIVGTPETTAEEFAANRYANTSVIVVAAFLLVYTGNWEDLWTLFGGANQLLAAMALLTATVWIANWDETKQLVSTGVPMALMAVVTICGLLWTTLYTVLGGRLLGETADAETELLAQLSAIAQLVIGLTLVGLAVGLIWMGYNNIQDVRGFGAGEQVAADGGEPDQPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W509</accession>
    <name>R4W509_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S24/S26A/S26B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446341.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07510"/>
    <dbReference type="EnsemblBacteria" id="AGN01447">
        <property type="protein sequence ID" value="AGN01447"/>
        <property type="gene ID" value="L593_07510"/>
    </dbReference>
    <dbReference type="GeneID" id="16182142"/>
    <dbReference type="KEGG" id="sali:L593_07510"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1538"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054902_1_0_2"/>
    <dbReference type="OrthoDB" id="106361at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="265" mass="27573" checksum="157CC600C6851FAC" modified="2013-07-24" version="1">MSDSGGPDPHRGDDVSSDAQDADDAASVAPKGDGASAQPPDAGPPPRAGRAATVPDPSERPILWYLKTERPLVVASRDILSSVLLVTILGLALFAVSGVWPPLVAVESGSMEPNMQRGDLVLVVEEDRFSSRLADEHGIVTAAAASGTEHEQFGEPGSVIVYRPNGEGGTPIIHRVAFAVDEGDNWVAMADSAHLGNVDECTDVASCPADYDGYITRGDANAQYDQVAGQSTVVKPGWIRGRAVSRTPYLGCIRLALSEGGVCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R4W523</accession>
    <name>R4W523_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446366.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07635"/>
    <dbReference type="EnsemblBacteria" id="AGN01472">
        <property type="protein sequence ID" value="AGN01472"/>
        <property type="gene ID" value="L593_07635"/>
    </dbReference>
    <dbReference type="GeneID" id="16182173"/>
    <dbReference type="KEGG" id="sali:L593_07635"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1565"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035203_0_0_2"/>
    <dbReference type="OrthoDB" id="45411at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="407" mass="44212" checksum="413948369073781F" modified="2013-07-24" version="1">MDIASIVSDDFVEFTPDTTVSKLAGTFDDPGVKGVVVRGDQFEGVVTRRQLATSHLQPNETVGSLVWHVPKLAPNEDVRKVAQLMIDSDSRVLPVFEGRDLIGVVDVDGILEAVQEFLDAATVAEAQSADLVSLDPDATVGEAIHEFRDRRITHLPVVEADEAIGILSLYDVTDVTVRAVTQSQGGDAGGTDAFGGEISASSGRSGRGGFGAREGESARLLDLPVRDLMVSPVRTIHPEATLEEAVEEMFDVGGSSLVVTRNGSPHGIVTKTDVLESLTWEAGGNRGVQVYGTELIDDVSYDDVVAMIDTFDSRDDDMNVLEAKVHLHEHDEKHRGTPLLLARIRLHTDRGLFVASGEGYGASQALNEAQDVVERQIRDQKTHGKSKKHRDEAFWEKRFGWLLEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W552</accession>
    <name>R4W552_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S6 modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_07885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07885"/>
    <dbReference type="EnsemblBacteria" id="AGN01522">
        <property type="protein sequence ID" value="AGN01522"/>
        <property type="gene ID" value="L593_07885"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07885"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1615"/>
    <dbReference type="eggNOG" id="arCOG01589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="97"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="298" mass="32598" checksum="354767AC181BF353" modified="2013-07-24" version="1">MSEVQVGILYSRIRKDEKLLLSELRERGHDVVKIDVRKEVFDVHGAPEALQELDVVLDRCLSTSRSLYATQFCEAYGVPVINSAHTADVCADKVKNSLALQGAGVPTPRTKVAFTKDSALEAIEQFGYPCVLKPVIGSWGRLMAKIDSRSAAEAILEHKATLGHYEHKVFYVQEFVEKPGRDIRVLAADGEPIGAMVRSSDHWLTNAAKGADVEEFELDDRARELVETASDAVGGGLLGVDLMETMDGDGNVDDYTVHEVNHTVEFKALDDATDVDVPSRVIDWLEATVADDSVEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W564</accession>
    <name>R4W564_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mur ligase family CapB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01542">
        <property type="protein sequence ID" value="AGN01542"/>
        <property type="gene ID" value="L593_07985"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07985"/>
    <dbReference type="eggNOG" id="arCOG06251">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759963_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="364" mass="38178" checksum="E1FA67D2740BC8C4" modified="2013-07-24" version="1">MFEPPWSVTDWNSPREPQRGDAGSGGGLRGSLRRLLRPRRGAVEARVFVLGTVGTDAVTDRLCAVLDRRGHATRAVTIGEGDPALRGRGERGAVETLVVNAHDDSEAVRRAQDMLGPPDVVVVTAAGRDSRAARGPGRGDVVRSIAGSVPAGAHVVNAEGTPAVRRYLATAVERRGATISHVGAHDADAPGAELGSAIDGALAALEEPPMPDEEREAFAAASHPEWLDLRAGRCYDALGVTDTVALERLRYALCPDREPIELVVVTDRERRDVAATLADYASDCHERRLIPTVYAIGPLSAQFADRCTAPTVDRGGDAPAGRVLDEALAAGPTIVVGPEGTPAGTAIADSITERIERSGTARIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W5V0</accession>
    <name>R4W5V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020444902.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00265"/>
    <dbReference type="EnsemblBacteria" id="AGN00008">
        <property type="protein sequence ID" value="AGN00008"/>
        <property type="gene ID" value="L593_00265"/>
    </dbReference>
    <dbReference type="GeneID" id="16181229"/>
    <dbReference type="KEGG" id="sali:L593_00265"/>
    <dbReference type="eggNOG" id="arCOG02395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870825_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="136" mass="14238" checksum="388B74CF758E4B1C" modified="2013-07-24" version="1">MGDPGGAGASGIDVLPLHVGEGTYAVKLDRVATVLRTGVLDDVEHGTVIDLAEHTIEIAAAATLLGERSTEESAVVVFHGKGTNGHVPGWLVTDVGDPTAIEEVKPTVGSIRHVRGKVLLDDESVVLVDPIRIHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W630</accession>
    <name>R4W630_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445027.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00890"/>
    <dbReference type="EnsemblBacteria" id="AGN00133">
        <property type="protein sequence ID" value="AGN00133"/>
        <property type="gene ID" value="L593_00890"/>
    </dbReference>
    <dbReference type="GeneID" id="16182291"/>
    <dbReference type="KEGG" id="sali:L593_00890"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.183"/>
    <dbReference type="eggNOG" id="arCOG04855">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077876_1_0_2"/>
    <dbReference type="OrthoDB" id="95021at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="236" mass="26257" checksum="C407C2FD57E465A7" modified="2013-07-24" version="1">MQSDGFVVDEGTAFYGRTFEEYRRLFGLSCEDLRGRRMLDCPGGPGSFTAVAAQIGDSAVAVDPVYGPSVDELEAHCAGTIDEVVEQITEKRSFFDWSFYGDVATRERYARAAARRFLADYARCPDRYVEAALPDLPFRDDAFGLTCSANLLFLYDDRFDRDFHEAAARELARVTAGELRISGLQTLDADRSRFVEPVIGSLAPAGYTIERQAVEYRFQPGPTEVLVVTDLQDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4W635</accession>
    <name>R4W635_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_10710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446981.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10710"/>
    <dbReference type="EnsemblBacteria" id="AGN02087">
        <property type="protein sequence ID" value="AGN02087"/>
        <property type="gene ID" value="L593_10710"/>
    </dbReference>
    <dbReference type="GeneID" id="16182048"/>
    <dbReference type="KEGG" id="sali:L593_10710"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2208"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="43"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="395" mass="43396" checksum="B22DDEC01D083F7B" modified="2013-07-24" version="1">MSEQEDSRSREEPGHQFTISQRVQNTPPSGIRRFFELAEEAEDVISLGVGEPDFSAPWAARDAAIHSLEQGRTSYTANRGKRELREEISQHVDDSYDLQYDPDDEILVTTGVSEAVDVALRAIVDPGDVVAVPDPTYVSYEPGVRFAGGESWPIPTAQDDFRLTPEAMREAGAEDADVLLYCYPNNPTGAIMPEEELREVAEFCRENDLVVLADEIYADLTYGQEHVSIATLPGMRERSIVLNGFSKAHAMTGLRLGYAMGPPDVIAALNRIHQYTMLSAPTTAQHAAIEALRSCDDEVEDMVAEYDRRRRFVLSRFEELGMDCFEAKGAFYVFPEVPGGDAEAFAEDLLTEAGVAAVPGDVFGEGGAGHLRVSYATGLDDLKEATNRIEAFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W672</accession>
    <name>R4W672_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_11035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447046.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11035"/>
    <dbReference type="EnsemblBacteria" id="AGN02152">
        <property type="protein sequence ID" value="AGN02152"/>
        <property type="gene ID" value="L593_11035"/>
    </dbReference>
    <dbReference type="GeneID" id="16180557"/>
    <dbReference type="KEGG" id="sali:L593_11035"/>
    <dbReference type="eggNOG" id="arCOG00702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304768_0_0_2"/>
    <dbReference type="OrthoDB" id="53822at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="202"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="7">
        <location>
            <begin position="797"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN02152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="974" mass="99447" checksum="DAB87E81D509BE11" modified="2013-07-24" version="1">MPDSVPSTGRRAFLGAVGGGGLATVAGRLDAEWHRAAAADEPLDVVVRFEGIDDPRSIEENAVSRLKQHAGASHDNFRRFAATTAGIEIRREFWLADAVLARVDPGVVTLEAIAAVDAVSEIRPNDATSMTEGAIDRDSAVGSDLPRAKDRTDGARRRTGRAKSATTAGSARIGQQGDGAGPSYGLEQIHAPTVWDFYGARGEGVDVAVLDSGVDPEGHEGIQSALDRGGWMEFDDGGERVESDPYDPNGHGTGTSGLVVGDTTDDGVQYGVAPAAALYHAKVVGEDGLAFAPIVAGLEWAIEQGVDVVSMSLGPLSYPAQLVEPLENARASGVLVVGAVGNAGHYTSASPGNMPTVVGVGAVDRDGTVTDFSGGERILTDRYWGGAAPDGWPDEYTVPDVTAAGVEVPSAEPGGSYSGAGGASAAAPQVAGAAALALSAARAADADGVGVEDLERALVDAAVHPDRDDPFAVDPGEDDRYGAGVASALFAATELVAGHTITGTVYRPDGSPMPGALVGAEVGRRTRTDAEGRFELTLPAGEQPIGAGAIGYEVDATMLDPASTNEVEFTPTPADGPAVGLTEAPPDRIEAGGAATATFTAANVEFATVDVTTEGLLQRADLGLRVNGKSAQFGEPVEVDAVDRTPEFTVTIEVPEGARVGSVTADLAVSRNGEDRFGELPTVRVHSDPLRVGERVPSIQAPVDLVAPGTTIELGDATFSGSGGDGPSTLRLNKPVSLVAATDASPRIEIDGASDRPGIYVGANDVEIDGVTIDAPGASAGVQIGTEPQNRETDAPSAATIRNGTVRGGDTGVDVRVAPAAVVEANDVTGETVGISIIGPGATIVRGNDVHDVETGLALDGLAREVADNRFRGIGGTAIRVGTPQSRLDQLDAEPGPIRNNVVEGAAIGIEVTDGAAVGDISGNEFREVESEIVGLDGAGSVEEDSAWHLVLYGATGLSLVALLVPYARRRITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B6</accession>
    <name>R4W6B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PLP-dependent enzyme possibly involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447096.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11285"/>
    <dbReference type="EnsemblBacteria" id="AGN02202">
        <property type="protein sequence ID" value="AGN02202"/>
        <property type="gene ID" value="L593_11285"/>
    </dbReference>
    <dbReference type="GeneID" id="16182181"/>
    <dbReference type="KEGG" id="sali:L593_11285"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2328"/>
    <dbReference type="eggNOG" id="arCOG00118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_2"/>
    <dbReference type="OrthoDB" id="37018at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="342" mass="36521" checksum="7B09532AED905E83" modified="2013-07-24" version="1">MDVIEDGRLADGPAVREFEAAFSDYCEATHGVAVANGTAALTTALRAIGIGPGDVVVTTPLSFVATANAVRLVGATPVFADVDPERYTLDPAAVRATIEDCGGEVDCLLPVHLYGLPAPMDELGAIAEEYDVPIVEDAAQAHGAELDGRRVGSLGDVACFSFYPTKNATTGEGGMIVTDDEDVADRARRYLNHGRTDSHVHESVGHNLRMTSIAAAIGGAQLRRLPRYTAARRRAAERYTEALEATPSVLAPIEPAGARHVYHQYTVRTPDRDGFRNYLESNGVDTGVYYPTPIHRQPAYDRAAILPVAEQATEEVCSIPVHPGLSAAEVEQIATLLGEYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6C4</accession>
    <name>R4W6C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_11360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447111.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11360"/>
    <dbReference type="EnsemblBacteria" id="AGN02217">
        <property type="protein sequence ID" value="AGN02217"/>
        <property type="gene ID" value="L593_11360"/>
    </dbReference>
    <dbReference type="GeneID" id="16180764"/>
    <dbReference type="KEGG" id="sali:L593_11360"/>
    <dbReference type="eggNOG" id="arCOG04934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087512_0_0_2"/>
    <dbReference type="OrthoDB" id="89381at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="277" mass="30982" checksum="753D447CDCD19063" modified="2013-07-24" version="1">MTSEDGERDGRADPAIATASTARSIDSDRGTADPWSQAPDDAAGIPYELDVYAGLLETLLARGYEFVGFDGAIEDGQIALRHDVDLSLSRAAEMARVEAALGIESTYCLQVTAPLYDLLVPENRRHVRTIVEAGHDVGLHFDPHYYWESEPVVDDLELRVLDDRSALSRVIADDFHRSVSVVATSIHQPPNWALGATFEAFQSTYEPRYFLDVEYVSDSAGKWRVQRPFEDEVPDAMQLLVHPGLWHREDHSLAAILEDHREQCRERIDRYVGAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6G8</accession>
    <name>R4W6G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02110"/>
    <dbReference type="EnsemblBacteria" id="AGN00373">
        <property type="protein sequence ID" value="AGN00373"/>
        <property type="gene ID" value="L593_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02110"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.429"/>
    <dbReference type="eggNOG" id="arCOG04662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070751_2_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="200" mass="21646" checksum="4A9EE74D864082DF" modified="2013-07-24" version="1">MEISLIGLLFVGVERGSPGIIVNTAVALAVFRLPAVLERDYGLPMDPRLTLWISAAAFLHAVGTVGIPGMGWTFYKGLWWWDHLTHSLSASVVAAAGYTTVRAIDIHSEEVYVPPRFASVVILIFVLAFGVLWELLEFAIAVAADEIGTATVLTQFGVEDTLKDLTFNTMGGILVAIWGGIYLTDLSSAMSEKFARRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6I1</accession>
    <name>R4W6I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagella protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_11970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447231.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11970"/>
    <dbReference type="EnsemblBacteria" id="AGN02337">
        <property type="protein sequence ID" value="AGN02337"/>
        <property type="gene ID" value="L593_11970"/>
    </dbReference>
    <dbReference type="GeneID" id="16181408"/>
    <dbReference type="KEGG" id="sali:L593_11970"/>
    <dbReference type="eggNOG" id="arCOG02964">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492314_0_0_2"/>
    <dbReference type="OrthoDB" id="97553at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006752">
        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arch_fla_DE" evidence="2">
        <location>
            <begin position="449"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="553" mass="56780" checksum="1C41A1FFE9956087" modified="2013-07-24" version="1">MGDEDSNGVVGRVADVLARLGGDPRGARPASSTERSDQPAFERATSRADPAIGSEEARPVTDGGADGVPPGESPWPDDDPIVFGSDAESERGTAILDAVVDSEAEDAPPFSAADQEDSDAAAGGADPRDADGSPPNAGIDPDHLDELEARIEALESDHLHLESSIADVARSLDDLKGEVAGVGADVQSLVAVLGGIAIARDGAASGDDGANVEAILERAAVEAADVETADTETRAGSDAERSAESERSPESEPSLSEDECSASNERSSETEHPSETEHPSETEHPSEAANAPESDRSPGAVKSPDAEPSLDPGASTGGGDAADGSTVDGNGSTSDAQESTSDAKGSSFDPDEPPSGIHRGAGDPRRPPEGGDSTVAPSPSADHDPARELVDPRTDAVGARLRQFRDGFVDDPTADLPTGNGADEFRFEKVLLPTDGAAAPDLSNAELAKPYLEALPDGYAGDAVVLEWLDWLVSAADGATAAHAIRYYESIEWLTADVRDDLLGYLEGLGEQHQEGETAPAGTPPAALDLQDHLRSLQYVTELASGEVGSDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6L6</accession>
    <name>R4W6L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L593_02560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02560"/>
    <dbReference type="EnsemblBacteria" id="AGN00463">
        <property type="protein sequence ID" value="AGN00463"/>
        <property type="gene ID" value="L593_02560"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02560"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.519"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AGN00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="291" mass="30634" checksum="14480A8C3A8CF5FA" modified="2013-07-24" version="1">MLAVNVALVLAKAGAWYLSGSLAVGSEAINSLSDSAYSLVILAGLYLTTQPPDLEHPHGHERIEPFVSLFVAGAMILAGAGILYGATTAVIAGGADPPVGTSAIAVLVLAVVAKLWLYRYCRRVAERERSPAVAATAVDNRNDVLAAGAALFGVAGAQVGYPVLDPVAAGVVALFIAYSGVDIVRDNLNYLLGAAPPDHLREEIVERALSHPDVEGVHDVIAHYVGPEIDVSLHIEVEGDRTLAEAHDIESAVVQSIRDIDDVDDVFVHVDPKELGEWKAKIDDVETDPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6M6</accession>
    <name>R4W6M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447311.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12390"/>
    <dbReference type="EnsemblBacteria" id="AGN02417">
        <property type="protein sequence ID" value="AGN02417"/>
        <property type="gene ID" value="L593_12390"/>
    </dbReference>
    <dbReference type="GeneID" id="16179914"/>
    <dbReference type="KEGG" id="sali:L593_12390"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2548"/>
    <dbReference type="eggNOG" id="arCOG06847">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_2"/>
    <dbReference type="OrthoDB" id="86381at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="217" mass="23180" checksum="3AEF9296DFE7EE56" modified="2013-07-24" version="1">MERSRREPAGTDVAIPVDGVELEGALALPTDGTGVVVFAHGSGSSRFSPRNNQVADVIRDRGLGTLLFDLLTEQEDRSRENRFDIPLLTDRLVAVAEWLWNRPDAADATVGFFGSSTGAAAALRAAARFGDDVDAVVSRGGRVDLASDVLGEVRAPTLFVVGGADSMVLRANREALERLDCEKSLHVVEGAGHLFEAPEELAEVADVSASWFAQHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6P8</accession>
    <name>R4W6P8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_12565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447346.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12565"/>
    <dbReference type="EnsemblBacteria" id="AGN02452">
        <property type="protein sequence ID" value="AGN02452"/>
        <property type="gene ID" value="L593_12565"/>
    </dbReference>
    <dbReference type="GeneID" id="16180067"/>
    <dbReference type="KEGG" id="sali:L593_12565"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2579"/>
    <dbReference type="eggNOG" id="arCOG02744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772949_0_0_2"/>
    <dbReference type="OrthoDB" id="73051at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="349" mass="36732" checksum="77932C206EE19C04" modified="2013-07-24" version="1">MDAYLTRRGKFVVLVTVGCILLGSVFGARSLNAIVAPAVVALVASFVSVRRAPAPTIHRTAPPDGHPDETHAVSLQIGGCGSGIYELRDRVGAGLSAPDAAYDVTETSTTVSYDVRYTRRGVHRLGPLSITVTDVLGLAERELQPVDAREQILVYPELVDPPRGVRSALETVVDLEQRPGRDEFDSLREYVRGDSLRDVHWKSSAKQPDEALVVKEFVGRTPTDAVRLAVAPSGDRATVDAAARAAASVAVTLLDEGVEVGIETPRDSIDAGVGSAQRESILAALARLQAGEPTAADSTIRISAADGEAVVHAGSHAVPFTHGRPQTSNDVEAADGVDDGAEPSREVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y0</accession>
    <name>R4W6Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_13215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447476.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_13215"/>
    <dbReference type="EnsemblBacteria" id="AGN02582">
        <property type="protein sequence ID" value="AGN02582"/>
        <property type="gene ID" value="L593_13215"/>
    </dbReference>
    <dbReference type="GeneID" id="16180470"/>
    <dbReference type="KEGG" id="sali:L593_13215"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2704"/>
    <dbReference type="eggNOG" id="arCOG01346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_5_2_2"/>
    <dbReference type="OrthoDB" id="114057at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="82" mass="8831" checksum="DAA972DDCAB7F2F8" modified="2013-07-24" version="1">MTDADLRAEAHDLDVTVWVGKGGIEPVIDECNDQLAARDLVKVKFLRAARGGTTVEDLAEDLAEATSADLIETRGNTAVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6Y4</accession>
    <name>R4W6Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_03435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445532.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03435"/>
    <dbReference type="EnsemblBacteria" id="AGN00638">
        <property type="protein sequence ID" value="AGN00638"/>
        <property type="gene ID" value="L593_03435"/>
    </dbReference>
    <dbReference type="GeneID" id="16180544"/>
    <dbReference type="KEGG" id="sali:L593_03435"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.695"/>
    <dbReference type="eggNOG" id="arCOG01835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_1_2"/>
    <dbReference type="OrthoDB" id="98354at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN00638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="118" mass="12724" checksum="0C95E38FE99A11FF" modified="2013-07-24" version="1">MSGITSALRSLPDAVFADLLESDDAYLLVLDLPGVTEDTLDVTVATGRLHVEAHRDKPDVAGYRFVEEHRDAFLDVDLPLPPDAVAEDATATIEQGVLEVTIPREPEAEVTEIEVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W734</accession>
    <name>R4W734_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00698">
        <property type="protein sequence ID" value="AGN00698"/>
        <property type="gene ID" value="L593_03735"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_03735"/>
    <dbReference type="HOGENOM" id="CLU_3353958_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="36" mass="3980" checksum="07885E2934282153" modified="2013-07-24" version="1">MSDQHKCEACGATFESMDELEVHAREEHGAETDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W755</accession>
    <name>R4W755_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psmB</name>
        <name evidence="9" type="ORF">L593_03985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445642.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03985"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="AGN00748">
        <property type="protein sequence ID" value="AGN00748"/>
        <property type="gene ID" value="L593_03985"/>
    </dbReference>
    <dbReference type="GeneID" id="16180778"/>
    <dbReference type="KEGG" id="sali:L593_03985"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.810"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="4 6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5 6" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005079830" description="Removed in mature form; by autocatalysis" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023237214" description="Proteasome subunit beta" evidence="6">
        <location>
            <begin position="45"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="239" mass="24854" checksum="C6B9BD0861F8FB54" modified="2013-07-24" version="1">MRQPPTAPQTPAGIDDGPEDPFAPRLGSLPDTGQEDLDSVAKTGTTTIGITTEDGVVIATDQRASLAGRFVANKDVQKVEQVHPTAALTMVGSVGGAQSFISSLRAEANLYEARRGESMSMQALSTLAGNFIRGGPFFAINPILGGVDEEGAHVFTIDPAGGVMGDDYTVTGSGMQLAYGTLEQEYEDGMSNEEAIGVAAQGIQSATERDTGSGNGIYVAEVTDEGVEIHGHESYDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4W766</accession>
    <name>R4W766_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445677.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04160"/>
    <dbReference type="EnsemblBacteria" id="AGN00783">
        <property type="protein sequence ID" value="AGN00783"/>
        <property type="gene ID" value="L593_04160"/>
    </dbReference>
    <dbReference type="GeneID" id="16181648"/>
    <dbReference type="KEGG" id="sali:L593_04160"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.846"/>
    <dbReference type="eggNOG" id="arCOG04707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745501_0_0_2"/>
    <dbReference type="OrthoDB" id="119032at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043808">
        <property type="entry name" value="DUF5790"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19103">
        <property type="entry name" value="DUF5790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="148" mass="15614" checksum="CF12B0F2D745BFA5" modified="2013-07-24" version="1">MSQSTLADDDLFGEAASEMRADVEDSLEQARGALPAADDVWDVDADNTLGVLNGLKTALDVGDAVDHLRDAKKWYTMGERADAFEDAEDLEAEIESVEELIETVDAAHEDVGNLTSTIPELRGSLEEAAAAAGDATDADGGDETVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B2</accession>
    <name>R4W7B2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carA</name>
        <name evidence="3" type="ORF">L593_04595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445762.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04595"/>
    <dbReference type="MEROPS" id="C26.A33"/>
    <dbReference type="EnsemblBacteria" id="AGN00868">
        <property type="protein sequence ID" value="AGN00868"/>
        <property type="gene ID" value="L593_04595"/>
    </dbReference>
    <dbReference type="GeneID" id="16181056"/>
    <dbReference type="KEGG" id="sali:L593_04595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.938"/>
    <dbReference type="eggNOG" id="arCOG00064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_2"/>
    <dbReference type="OrthoDB" id="35557at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="358" mass="38537" checksum="6E9DBE6BC21518B3" modified="2013-07-24" version="1">MDAYVAVEGGQVLEARGRSPGRTNGELVFTTAYTGYEESLTDPSYEEQILTFSYPLIGNYGVREERFESDRVHPRAVVSRELTDDVADWLAEEDVPAVDHIDTRDLVVDIREEGAMECGIAVGEDVTPEDALAELEDCVPMSDHTDIGAQVTVDELTTFNAEGDGAEVALVDCGAKGSITNSLVERGATVHVLPYDATIEDVDAIDPDLLFISNGPGDPANFEAAIELVEDALDEYPLAGICLGQQIVAEALGGETEKMAFGHRGVNQPVMDLRTDQVVMTTQNHGYSVAEPGDVLEVTQINVNDDTPEGLESDEHEIITRQYHPEAHPGPHDSLSFFDDVLAMTDGAPADSAAVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B5</accession>
    <name>R4W7B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN02797">
        <property type="protein sequence ID" value="AGN02797"/>
        <property type="gene ID" value="L593_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14290"/>
    <dbReference type="HOGENOM" id="CLU_2461909_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9497" checksum="17D6197F02B87E76" modified="2013-07-24" version="1">MEGIDVSGTDRGAERRRLLAAVRDDAESDAESDERSSAQTGPSPTTDGGVVTLSAPLYHCTACDRTYLEEPITCLGCGERSFERRTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7B7</accession>
    <name>R4W7B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase hexapeptide repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447696.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14315"/>
    <dbReference type="EnsemblBacteria" id="AGN02802">
        <property type="protein sequence ID" value="AGN02802"/>
        <property type="gene ID" value="L593_14315"/>
    </dbReference>
    <dbReference type="GeneID" id="16181183"/>
    <dbReference type="KEGG" id="sali:L593_14315"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2930"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065082_0_0_2"/>
    <dbReference type="OrthoDB" id="37174at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="300" mass="34018" checksum="173DAFF03E911053" modified="2013-07-24" version="1">MTKRHVSLPADAEAGVRAFIDEVDERLASDEDTCRVVTDVLVDLFGDREAYERWQDGGDVSPAERVRLQSYDPCNATLESEYYAEKDEETFRESKYLQWLWRQFDATPLADNVEFALRFRSMLAQHLFAECGDDCRFFKNITFTYGHNIEVGDNVVVHDDVHLDDRGKLTIGDRVSISDNAHVYSHDHDVVDQTEITNYHTIVEDDVRLTYDTMVRAGCKIGENALVGAKSSVTSDIPAHHIAVGSPAKSVRVKPGWEPVAAPLEDSQETDREDRIIEHDVSDDRPIFDEFERDLQPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7D5</accession>
    <name>R4W7D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447741.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14540"/>
    <dbReference type="EnsemblBacteria" id="AGN02847">
        <property type="protein sequence ID" value="AGN02847"/>
        <property type="gene ID" value="L593_14540"/>
    </dbReference>
    <dbReference type="GeneID" id="16181536"/>
    <dbReference type="KEGG" id="sali:L593_14540"/>
    <dbReference type="eggNOG" id="arCOG13609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493035_0_0_2"/>
    <dbReference type="OrthoDB" id="88207at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="180" mass="19321" checksum="4A9A74849BD43AD9" modified="2013-07-24" version="1">MSQLVWLLDRGAALVTYPALYLAVLTGILYNTESFGMLHEAAQRIHIELSVFAMIVTLLHAVLGVLDAWFVVTGQVPAPAYSMPYFLGGITVGAGALLMLVVAVLGFTDAKRFQRPWGPRVVHSFAYAGFAFGTIHAAAIGTDLTGLIRPLLGPSVAFLVYVLLLRLLVLREIPSNATPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7F9</accession>
    <name>R4W7F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_14765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447781.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14765"/>
    <dbReference type="EnsemblBacteria" id="AGN02887">
        <property type="protein sequence ID" value="AGN02887"/>
        <property type="gene ID" value="L593_14765"/>
    </dbReference>
    <dbReference type="GeneID" id="16181456"/>
    <dbReference type="KEGG" id="sali:L593_14765"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3015"/>
    <dbReference type="eggNOG" id="arCOG09161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055389_0_0_2"/>
    <dbReference type="OrthoDB" id="88696at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="293" mass="32331" checksum="B1AA49B5F34BE327" modified="2013-07-24" version="1">MTENGRLALVFDDGYRSDFAQLRPVLDARDAPASFAIVSEWVARDGHLDVDQLRDLVDLGGEVLAHGRYHRVLRPHHLADDVAADARRIPIESHVFPENESGVHVGDEYELVDADRRQTVTVAGKGSDEAAPYVELAEPVADSWSASETVFRLPDRLLDAEIRGSGADLRDHGFEPAGFVFPYDAADVRAHRIARSEYGVIPNAAVRSLPNPSGTPAWNLRRYYLETDALTRVEIADYLDAVARDGGFGILAGHSDWDTVPAERVRFVIEAARDRGIELTTFSECVGTADRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K1</accession>
    <name>R4W7K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447851.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15115"/>
    <dbReference type="EnsemblBacteria" id="AGN02957">
        <property type="protein sequence ID" value="AGN02957"/>
        <property type="gene ID" value="L593_15115"/>
    </dbReference>
    <dbReference type="GeneID" id="16182429"/>
    <dbReference type="KEGG" id="sali:L593_15115"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="174" mass="19253" checksum="DEB0D0535225A849" modified="2013-07-24" version="1">MDVTDVIQTAISVREFTDEPVDTETKRAILDAGHLSQSGHNSQHWRPILVDDADDLARLAELSTSGSWVADADFAVVIVTNPERHYHEIDAGRTITHMQFAAWDRGIGSCIYTGFHEAGTRECLDVPEDLEVTAVIGFGHPTFDVESLRGRKDREPLDEIVSHGRYGNPLALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7K7</accession>
    <name>R4W7K7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="9">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysS</name>
        <name evidence="11" type="ORF">L593_15165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447861.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_15165"/>
    <dbReference type="EnsemblBacteria" id="AGN02967">
        <property type="protein sequence ID" value="AGN02967"/>
        <property type="gene ID" value="L593_15165"/>
    </dbReference>
    <dbReference type="GeneID" id="16181781"/>
    <dbReference type="KEGG" id="sali:L593_15165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3097"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OrthoDB" id="20883at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="10">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AGN02967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="492" mass="54823" checksum="6F842A68E3CF0694" modified="2013-07-24" version="1">MTLRLHDTLSGETTDFEPIGDAVTLYLCGLTTSDPAHLGHARVWLHTDVLHRWLEYSGYEVRHVENFTDVNEKVLARVGEVGDSEADVGRHYVAEFLDDMRSLRLKRATVYPRVTEHVEEVVAMVETLLEKGYAYESNGSVYFDVTSFEDYGKLSGQQIDELEAQGPEDERSEKRHPADFALWKADGVGPEEIVEHQHEEAADPEDACETALTWDSPWGEGRPGWHIECSAMSTTHLANTFDIHVAGEDLVFPHNENEIAQAEAATGQPLTNHWLHVGLLETGDEKMSSSLGNFYTVEEGIEKFGADVVRTFLLSATYSEKQAYSEAAIEEAQERFERLERGYERAVAVADSPDSKTKVRDDSLRSAVATAREEFGRAMDDDLNTREAFAALLELTSAVHEHLDSYDDADYQGLRSAIEAYDKLGGGVLGLRFGATEAGDVTIAEELVELVLEVREQQRAAGNYEQADELRADLESIGVEVQDTDEGPEFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7L8</accession>
    <name>R4W7L8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Blue copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_05445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
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            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AGN01038"/>
        <property type="gene ID" value="L593_05445"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1333523.5.peg.1111"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012344_3_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
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        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
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        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="202"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="657" mass="70619" checksum="92F4A8629D6B6A8C" modified="2013-07-24" version="1">MGERIPADDSGRTDAIEPYRPTRRRLLQGTVAATALGALGGVPAASGQEDDDGEDDGEAGGEPIDPAETIVLGGITEGWEGREPEAIAGATNPTLQLVAGETYELTWINVDGLPHNIAFLDADGNALLQTEIVDEQDAEQTVSVSVTEELATYVCEVHPSSMRGSITVGEAGDEPAQDAAEPLVPQGQEVGLQKIAGDPISQPVGMETVTVDDAEERFVVDQTGEIYHVTDDGVEEFLDISPRIVMDNDGFDERGLLGLAFHPDYQENGLFYVRYSGWPEGGEALPEDYDHLFVLAEFQASEDDALQGDPESERRLVTIPEPQFNHNGGDIAFGPDDYLYVSVGDGGGADDTGLGHVEDWYDANGGGNGQDVTDNLLGSILRIDVDTEGEDRPYGVPEDNPFVGTEGMDEIYAYGFRNPWRFSFDVSAGEEEEETEWAWGGSDSGSDGEGDLLVADVGQNLWEEIDRVEAGGNYGWNVFESFHCFSTESPSDPQAITDCPTEEPDSAPYDGSALLDPVLEYPHQIGDQVVGISVTGGYVYRGGELSDLDGRYVFGDWSAGFERPNGRLFVADLPEQGEAEGFDVPVTEDAEFPMEELQVAGSEDGTLNRTVLAFGRDQADELYVLTSQTPSVDGTGEVFRIVPPGEGEEIPPLEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W869</accession>
    <name>R4W869_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02115"/>
    <dbReference type="EnsemblBacteria" id="AGN00374">
        <property type="protein sequence ID" value="AGN00374"/>
        <property type="gene ID" value="L593_02115"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_02115"/>
    <dbReference type="eggNOG" id="arCOG07497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170795_0_1_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="88" mass="9428" checksum="01B013B860FF652D" modified="2013-07-24" version="1">MSNGPPDHSQDELAPPPGSRLLLSARRASETFGGPLRAIAFWCAAMLPFVYVPLLLFGLDTRRRAGAFGLLVFAHVVTLVVGRSHGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R4W870</accession>
    <name>R4W870_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07940"/>
    <dbReference type="EnsemblBacteria" id="AGN01533">
        <property type="protein sequence ID" value="AGN01533"/>
        <property type="gene ID" value="L593_07940"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_07940"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1627"/>
    <dbReference type="eggNOG" id="arCOG00533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088141_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="299" mass="32386" checksum="B21632E142752E7A" modified="2013-07-24" version="1">MPSDQSIGASSGDTYKAGAAPHSPMQVLGVVGPSDSGKTTLVERLATRLADRGRVATVKHCSHDPDLDTEGKDTARHRAAGADATYGLTDDAGWFATGADRSLEATLDDLAPDYDYAVVEGYTDAYLPQVELGGREGAGTVLQRAERAADVDLEALIATLEATDPHETLEALVARVERSADADRAGAIATFTGRVRAKDSPDDERTEYLEFERYDGLAEERIDALQADLEAREDVFAVALHHRTGIIEAGEHVVFVVVLAGHRESAFRAVENGIDRLKAEVPLFKKEVTVSEEFWRHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W873</accession>
    <name>R4W873_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445278.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_02165"/>
    <dbReference type="EnsemblBacteria" id="AGN00384">
        <property type="protein sequence ID" value="AGN00384"/>
        <property type="gene ID" value="L593_02165"/>
    </dbReference>
    <dbReference type="GeneID" id="16180090"/>
    <dbReference type="KEGG" id="sali:L593_02165"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.439"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_3_1_2"/>
    <dbReference type="OrthoDB" id="19042at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="1">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="404" mass="44978" checksum="723BC0EB1D202436" modified="2013-07-24" version="1">MSTQVHTAVDESTVRQISEELGEPEWLLETRLEALDALEDLDMPDVIRTPGRTWTNLYDLDYESFVDPLNAAEEKDQEGPDDVEVLSIAEAVEQLPDVLEEHFGSVVDPQENYLTALSTALFSTGTVIYVPEEVDAEDVAIRTRMNSQSLFNYTLVVTEKSSSVTILERQSTGDTEVEGERFYSGVVEVAAGENSHVQYGALQNLDEETYNYTLKRADAGTYSTVSFVDGNLGSRLTKTEVSTELNGDGAETKIVGAFFGHDDQHFDLDSKVWHRAEHTTADLVMRGVVDDVARSVYEGVQDVGSMAWDTNSYQRENTLMLSDESEADASPKLIINNHDTEASHSATVGQVDQEDLFYMTSRGVDQKAARDMLVEGFFVPVLEEIEVEELRDDIQELVSQRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I2</accession>
    <name>R4W8I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446697.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN01803">
        <property type="protein sequence ID" value="AGN01803"/>
        <property type="gene ID" value="L593_09290"/>
    </dbReference>
    <dbReference type="GeneID" id="16182671"/>
    <dbReference type="KEGG" id="sali:L593_09290"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1908"/>
    <dbReference type="eggNOG" id="arCOG00006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151709_0_0_2"/>
    <dbReference type="OrthoDB" id="101947at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="119" mass="13491" checksum="995ECB3A446A1E09" modified="2013-07-24" version="1">MAEAQAVDGATARDLTAFQRHILTILAEEPMYGLAIKRELEAYYDDEVNHGRLYPNLDDLVEIGFVSKSELDKRTNQYELTDAGYAAVIDQLTWSLDRIVTDEQRADEVRAIVDDALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8I5</accession>
    <name>R4W8I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446707.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09340"/>
    <dbReference type="EnsemblBacteria" id="AGN01813">
        <property type="protein sequence ID" value="AGN01813"/>
        <property type="gene ID" value="L593_09340"/>
    </dbReference>
    <dbReference type="GeneID" id="16182438"/>
    <dbReference type="KEGG" id="sali:L593_09340"/>
    <dbReference type="HOGENOM" id="CLU_1076130_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="258" mass="26303" checksum="B19BB5D1A2D5E6FB" modified="2013-07-24" version="1">MAREAGPSAADRLGILGVDPADGRALAEVPRWVPADATALYSVPDVSDRFVAGRASASTPPVALLALARRLAGRGSFRTLPDEALPGDDAGLAAAVDAAAAECDVTRRDLTVDAGTQSASSRRRWVVGAWTVTLLAIGASLGSIARWLLIGDLLSGLLAILATVGSLALLVGFAFAAEAAAIRRFDHTLADAVTDALAADEDNSADSQGTGGTDRTAERPVLVVPARHAAGVAAILRERGVRARALRVEADASPATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J4</accession>
    <name>R4W8J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445583.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03690"/>
    <dbReference type="EnsemblBacteria" id="AGN00689">
        <property type="protein sequence ID" value="AGN00689"/>
        <property type="gene ID" value="L593_03690"/>
    </dbReference>
    <dbReference type="GeneID" id="16181369"/>
    <dbReference type="KEGG" id="sali:L593_03690"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.749"/>
    <dbReference type="eggNOG" id="arCOG02519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426783_0_0_2"/>
    <dbReference type="OrthoDB" id="5963at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="1">
        <location>
            <begin position="387"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="641" mass="67978" checksum="B7AD8DFD4E012B42" modified="2013-07-24" version="1">MIGRLLALAVVGVLVLLSFSLVVPIGGSQPPDAAAFGDTFELGLTDTTVREAEERGYAIPRVQVYYSGYQYVVGFNGLEAFVAEQDRTGHSRQFGRPVEIFVTDFGNANPSLTDDGFLQTEDTPNFVSATGTHVVVDSEARLPSGPVAVPFDDRDAAEQFADQYGGRVIDWEDLPDHVSPQQALTRERFQRDVRERSAWANASSRDAEQLRDRPTSIVVGEDVPTLEAAVGAAPSNTTIELPAGTYETDGLVVNRSVTIEGQGAATQLHGDGNGSVLAFTAPRTGLVNLSIDGVGPVGSRGTTVNGSEPEDIGWSERIELAYGRGDAAVKLVDANGSLVADVRIESPSSGVIVTDSAGATLRGLNVTITRGVDDGFMGVVGMYDPIVVEDSRFRGGRDGVYTHRADGIVVRDSEFRDGRFGVHEMYTSNALVTNNTARNVQIGVIVMTHPVGNLIVGNDVRSSRVGISTAGSNAYYAENVLVDNERGIDVLGYQSLIERNTIVRNGAGFRTSLGPPTNLVTANDVVANEQASSSSQGVLRVWTVRGAGNFWGPMPSADDDGDGHYDRTFRPTGSVDGQIHDANGAWTLARSPAFQLVRSVQDNVPGLRSGGVVDTAPRTAPARPDVLAAALNRTATTEGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8J6</accession>
    <name>R4W8J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446742.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09515"/>
    <dbReference type="EnsemblBacteria" id="AGN01848">
        <property type="protein sequence ID" value="AGN01848"/>
        <property type="gene ID" value="L593_09515"/>
    </dbReference>
    <dbReference type="GeneID" id="16182739"/>
    <dbReference type="KEGG" id="sali:L593_09515"/>
    <dbReference type="eggNOG" id="arCOG02874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094837_0_0_2"/>
    <dbReference type="OrthoDB" id="99006at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043826">
        <property type="entry name" value="DUF5803"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19119">
        <property type="entry name" value="DUF5803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="271" mass="30493" checksum="CCCA816E046D2153" modified="2013-07-24" version="1">MSPSTSTRRRLLLLFGLVGLLALSGCIGQFGTGLSEGELSRNATYEWDTSATADEWPDDVTVQIEINQAGFLGDDTYHGIYTGNRTQVTFSERGFTRPHSLDIRAVKYQYPNGTVVGHEAIDVDQNARRTRVRLPEGPGRFAWIGDRRNKELRLPAIADGNYTVTLPRHHSVGDFLLSDVSPRSYNTRTVDGHTQIVWTGVDNSQTLLVRFYRDRDFYLFYGLIGLLTVVGAGIFLHYRREIQEIQEWRAAQGLDLDRDDDDGERPPPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8K2</accession>
    <name>R4W8K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_09665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446772.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09665"/>
    <dbReference type="EnsemblBacteria" id="AGN01878">
        <property type="protein sequence ID" value="AGN01878"/>
        <property type="gene ID" value="L593_09665"/>
    </dbReference>
    <dbReference type="GeneID" id="16180280"/>
    <dbReference type="KEGG" id="sali:L593_09665"/>
    <dbReference type="eggNOG" id="arCOG04623">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036034_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="350" mass="36734" checksum="CC4202C52C770411" modified="2013-07-24" version="1">MTRHVAIVGAGVAGCATAYGLEDADAEVTVFERRTEAGGRAATRQREGCSYDVGANYLTAADDRVQQLVEGPLADDLVAVDGEVWTLDADESIAPGRDDGAPKWTGSRGVADIGPALLDPTDSDVRFDVDVAGIGCDDGTWTVFSNSLDGGDGTGAGDDARAGPFDDVVLTPPAPVTAELLRDVSVADSLRAAARSIEYRSITTVAARYEESFEWPYYALVDTSKTLDLGWIAREEAKPGHVSGDGSLVIFQASPQWSQRHQHAEDPALADAATDAAAALLDVSALADPVWTDVVRWKHALTDDGIATSVRTDPADAGLHVAGDWVAGESRLNAAIVSGLETADRLAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M0</accession>
    <name>R4W8M0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_09915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446822.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09915"/>
    <dbReference type="EnsemblBacteria" id="AGN01928">
        <property type="protein sequence ID" value="AGN01928"/>
        <property type="gene ID" value="L593_09915"/>
    </dbReference>
    <dbReference type="GeneID" id="16182856"/>
    <dbReference type="KEGG" id="sali:L593_09915"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2042"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_2"/>
    <dbReference type="OrthoDB" id="29058at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="286" mass="32432" checksum="9CEAADA6F2F1954A" modified="2013-07-24" version="1">MVDDTYANDVLVSPDWAEERLSEFESDDPGLRLVEVDVDTEAYDEAHAPGAIGFNWETQLQDQTQRDILEKADFEDLLGSHGISEDSTVVLYGDNNNWFAAYAYWQFKYYGHRDVKILDGGREYWLDNDYPTTDEVPDFSEQDYTARGPFEGIRAYRDDVEKAVERNIPLVDVRSPEEFSGEILAPPGLQETAQRGGHVPGAKNISWADTVQDDGRFLPHDELLELYESEGITDDQEVVAYCRIGERSSLAWFALSELLGYEDVTNYDGSWTEWGNLVDAPIEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8M8</accession>
    <name>R4W8M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04015"/>
    <dbReference type="EnsemblBacteria" id="AGN00754">
        <property type="protein sequence ID" value="AGN00754"/>
        <property type="gene ID" value="L593_04015"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04015"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078424_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="282" mass="30361" checksum="335E65BC44B3036C" modified="2013-07-24" version="1">MATAEEPAPAVGESDGAGARSDRTGAPSLLALVRVVLHKQVLLLVRYPVNTFSQFATIFAFFLAIFYGGQAVAGAALTDSLDGLIVGFFLWTMAIVAYSGLSWNVTREAQWGTLERLFMSPHGFGRVMTVKTAVNVLMSFLWGTLMLAFMMAVSGRVVTLDPVTILPLLLLTLGSVVGIGFAIAGLALLYKRVENLFQLVQFVFIGLIAAPVEGVPALRLLPMSHGSYLTGEAMAEGTAIWAMPAWELGLLLVTSTAYLLAGYACFQYAQRRARRQGLLGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8N5</accession>
    <name>R4W8N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_04115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445668.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN00774">
        <property type="protein sequence ID" value="AGN00774"/>
        <property type="gene ID" value="L593_04115"/>
    </dbReference>
    <dbReference type="GeneID" id="16180832"/>
    <dbReference type="KEGG" id="sali:L593_04115"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.836"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OrthoDB" id="52466at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="494" mass="51798" checksum="2EB9F8DC888BEA60" modified="2013-07-24" version="1">MTTGPITSRLFYLAWPLVVGNLLQTLYNLADMFWVGRVSSEAVAAVSLMFPLSWLFVSTAMGLSAATIAMVSQHVGAGNDRRADAVVGQTMLLAVAVASALAIAGYLGRHELMYLIGARGDVRVEALRYIEVIFLSLPLTFLFIAFRAALQGAGDTKTAMWLVAISAVANAVVDPFVILGVGPLPAMGVRGAAWATFGARGLAAAVGVYILLRGDWGIKLHPGDLRPDRELLAKLVDVGYPSTLDGWARSFAAVAMAGLVARFGEAATAAYGIGIRYMSVTWTVSGAVGQATATGVGQNLGAESPDRAASVAYRATAATMALLFAAGGLVWLVPATAMRIFVDDPAVVDEGVRFLRIVTIAWGFFGGLMVLQGAFRGAGSTRIAMALSLCSRWLFRIPLAVGLAFGWAITIPLLGVEIAALDWGAVGLWWAYAVGAIASFALGLVWFLRGTWTEGVIDRADEVPTDSTASGGTAGDTRSGTDPARTTETDVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8P1</accession>
    <name>R4W8P1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component 3</fullName>
            <shortName evidence="5">RNase P component 3</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rpp30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnp3</name>
        <name evidence="6" type="ORF">L593_10140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446867.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10140"/>
    <dbReference type="EnsemblBacteria" id="AGN01973">
        <property type="protein sequence ID" value="AGN01973"/>
        <property type="gene ID" value="L593_10140"/>
    </dbReference>
    <dbReference type="GeneID" id="16182093"/>
    <dbReference type="KEGG" id="sali:L593_10140"/>
    <dbReference type="eggNOG" id="arCOG00307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074509_1_0_2"/>
    <dbReference type="OrthoDB" id="66325at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00756">
        <property type="entry name" value="RNase_P_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023539">
        <property type="entry name" value="RNase_P_comp-3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="234" mass="25517" checksum="44ABB77032BA48AD" modified="2013-07-24" version="1">MYEAVHAVPEGESTVSRLAITAKEYGYEGIVVRNHGDQRAEFDAGAVAAETGVDVVNGVEIQAEDAQQASGYLGNFRPDYTLVGIHGGTIELNRFAVEQEKVDVLAHPMAEQGDLNHVMANAAAEHGVRIELNLRPVLRESGGTRVRAIKDLRKSWELIDDAGAPFVVSADPRSHLQLRARRELEALDEEIGIPGEAIEDGLAEWGRLAERNREIQSEAFIEPGVEAGRYDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8X2</accession>
    <name>R4W8X2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family L-lysine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_05300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05300"/>
    <dbReference type="EnsemblBacteria" id="AGN01009">
        <property type="protein sequence ID" value="AGN01009"/>
        <property type="gene ID" value="L593_05300"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_05300"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1082"/>
    <dbReference type="eggNOG" id="arCOG01947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087840_1_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN01009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="250" mass="25225" checksum="7CD620658FD4EF56" modified="2013-07-24" version="1">MSVALSLLGGVAFGLAMAAPPGPMNAVIAEESVRRGWTAGFRAGLGAMTGDAIFCVLAFVGVVEVVQHAPRLRAAMVGVGGALMLVFAVDAATGVKSAAGMEAPGTTTKDVEGTEAADETVASGALDRTTGFRKALVLALTNPYQIVFWLTVGVGLLRAGTLDLVTQAPWLGELLGTLGLGESLVIETGSLALLVGFFGGIGLWITGYPATLVAVDRRSERAGPVVAGISALVLGGFGILFLIDGVTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R4W922</accession>
    <name>R4W922_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_05925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446028.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_05925"/>
    <dbReference type="EnsemblBacteria" id="AGN01134">
        <property type="protein sequence ID" value="AGN01134"/>
        <property type="gene ID" value="L593_05925"/>
    </dbReference>
    <dbReference type="GeneID" id="16181371"/>
    <dbReference type="KEGG" id="sali:L593_05925"/>
    <dbReference type="eggNOG" id="arCOG02646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_3_2"/>
    <dbReference type="OrthoDB" id="81806at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AGN01134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="232" mass="25340" checksum="F8F069B7C71804CB" modified="2013-07-24" version="1">MDDPAADIMGATFRALCDHGYAELTMRDIAEESDRSKAALHYHYDDKEGLLVAFLDHMYDRFTDRVGGYGVDGDAALPDDVDASDPDERLRAFLSAVLHPPKDSDDVREFRTAMLEIKAQAPYSDAFRERIARFDAFVTETVTELVEAGQEAGIYRDSADPAHVAQFVLVTHDGADARHVIADAPVDCALASLEDYLDGYLVDDGADRTESGSEAPTSEQLTDGGRSEAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W944</accession>
    <name>R4W944_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">L593_12050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447247.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12050"/>
    <dbReference type="EnsemblBacteria" id="AGN02353">
        <property type="protein sequence ID" value="AGN02353"/>
        <property type="gene ID" value="L593_12050"/>
    </dbReference>
    <dbReference type="GeneID" id="16182406"/>
    <dbReference type="KEGG" id="sali:L593_12050"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2479"/>
    <dbReference type="eggNOG" id="arCOG03055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_5_0_2"/>
    <dbReference type="OrthoDB" id="14000at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_A">
        <property type="entry name" value="SecD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024912">
        <property type="entry name" value="SecD_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="530" mass="55613" checksum="1D63265C23B1304E" modified="2013-07-24" version="1">MSVLGAARENWRVLLLVVLLLASAFFLFFPGAPIAGAAAEGDGGGNATAGISNIQFGIDLAGGARISAPPNGYLVTGVDVTAENRIVVKESVADATNASTEDVVTSVDYGNNEGFPDDAVEVRADVSRQAVIDGLRNAGLEVSDGDVRHGVSEYTLDLMVDVLGSRLSESVFTGGEVRGAQTRNQPRDRIIIRAPGQSIEDLEQLVAPQGKVEIVAHYPNPNGSGAQRETLLTQEDFDAGTVDSSGENPFVPVTVTQSAADDMTAFMQDSGFAANSQGTVRCPTEDIPDSSYCILTVVDNETVYSSPLGGDLARGFQTGDFRQSRSFVVYAPDVATAQDLLINMRSGALPTTLDFDDSTQVLISPALAEDFRQNSLLTGVIAVIAVVLTVFARYGDPRVAVPMAATALSEVVILLGFAAAIGWPLQLSHVAGFIAVIGTGVDDLIIIADEVQAEDDVSSTRVFQSRFRKAFWVIGAAAATTIVAMSPLAILDLGQLRGFAIITILGVLLGVAVSRPAYGSILRSLTTDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W997</accession>
    <name>R4W997_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-seryl-tRNA(Ser) seleniumtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_06760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446193.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06760"/>
    <dbReference type="EnsemblBacteria" id="AGN01299">
        <property type="protein sequence ID" value="AGN01299"/>
        <property type="gene ID" value="L593_06760"/>
    </dbReference>
    <dbReference type="GeneID" id="16181857"/>
    <dbReference type="KEGG" id="sali:L593_06760"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1381"/>
    <dbReference type="eggNOG" id="arCOG07389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040896_1_1_2"/>
    <dbReference type="OrthoDB" id="35832at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="402" mass="42234" checksum="AF90D4E852C0769E" modified="2013-07-24" version="1">MDADTIYEELGAPSVINATGTKTRIGGSRIRPAAVEAMSEASQSFVRLSDLQAAASDRIAELTGADKGYVTSGAAAGMYLGAAAAIAGDDLAAMASLPDTEGLADEIVMSRTHRTGYDHALRSAGATIVDVGSNDRHLGTGSRNVEPWEIKRAIGENTAAMGYIQKEYTEPDLDVVCEIAHDHDVPVIVDAAAELPPTTNFERFIDAGADLVIFSGGKAIRGPQTTGIVAGRGDLIESIAAQHLDMHAAEAVYEPAPELVDVEALGGVPRQGVGRQCKVGKEELAGILVALEEFIAEDQDEKAAEWTDISMRIGDALGEIEGIDTRVPTDSAVSVAPEVIVSVDPEVAAGSATDVVRGLRQEEPRIFVGADSLESGAFTINPMCLAEDEIDYVIQRIRAHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9E4</accession>
    <name>R4W9E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_07445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446328.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07445"/>
    <dbReference type="EnsemblBacteria" id="AGN01434">
        <property type="protein sequence ID" value="AGN01434"/>
        <property type="gene ID" value="L593_07445"/>
    </dbReference>
    <dbReference type="GeneID" id="16182125"/>
    <dbReference type="KEGG" id="sali:L593_07445"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1521"/>
    <dbReference type="eggNOG" id="arCOG01464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066578_0_0_2"/>
    <dbReference type="OrthoDB" id="56663at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="355" mass="38775" checksum="FC46E5D68909D066" modified="2013-07-24" version="1">MDLIALLYKEAITVRRNLAPILLLVVLLPSAFALGTVVYQNTVPQDVPVAVVAEDDSTTEHDMQIVREGVRIFGEPREYERTEAAVDALTREQVYLVIEVPGGLDDPNATANFTVHADRGIVPFHEPSEVATDILNEELDALLAADVNARLERVGRDPSLSEYLVPTATMFFVVLYSLVFLPRQVRSERQVFDRLRTDSSLEAVLASKLIVWGLLLGVGIASIGLVTGYLGYSVAVFSPLVFGSVALSFVYLAATGLAVLFAMDCSESAIYVNFTIAGVTFAASSLFFPVGFFSSLRATIARLLPTHYSTVTMRSGMLKSVDPTLYLDYFGYMLVASIVALALLELSLVRYRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9G7</accession>
    <name>R4W9G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L593_07770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446393.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07770"/>
    <dbReference type="EnsemblBacteria" id="AGN01499">
        <property type="protein sequence ID" value="AGN01499"/>
        <property type="gene ID" value="L593_07770"/>
    </dbReference>
    <dbReference type="GeneID" id="16182210"/>
    <dbReference type="KEGG" id="sali:L593_07770"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_8_2"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AGN01499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="132" mass="14749" checksum="599B86B6717D7154" modified="2013-07-24" version="1">MARNPFSELERLFDRMESQFEGQASFGSTVAVDVVDEDDQFVVEAELPGFEAGDLELTYSEGRLSIVAEREEHVEADYVRSERKHAVERTVRLPEPVDADAIDADLDDRGVLRVTLPKEAPAEAGKRIEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9H3</accession>
    <name>R4W9H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L593_07845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446408.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07845"/>
    <dbReference type="EnsemblBacteria" id="AGN01514">
        <property type="protein sequence ID" value="AGN01514"/>
        <property type="gene ID" value="L593_07845"/>
    </dbReference>
    <dbReference type="GeneID" id="16182240"/>
    <dbReference type="KEGG" id="sali:L593_07845"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1607"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022234_0_0_2"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AGN01514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="746" mass="82905" checksum="74808B388667E31B" modified="2013-07-24" version="1">MASTNGYTRFFPYDEPFEGQREAMDRIYNALVRGQDVTFEGACGTGKTLAALAPALEHARETDKTVVITTNVHQQQRQFVREARRITEQEPIQAVVFRGKGSMCHVDVDYQECQVLRDATRDLVDLEQEQAELERRADALQASAQAGEEDATEAYGAVTEELERVETELENLQDASTCEYYRANLERDPAGFYQWLYDDVRTPDEIYERAEAAGFCGYELLKDGVDDVDLAICNYHHLLDPQIREAFLRWLDCDPEDVIVVFDEAHNVADAAREHATRTCTENTLEQALDELEATPDPRSDAAANVLAPFLAALRETYDENLGFGDVGEHWSDVAIDNDDRRDDLTLAFLQAYSGRGVEDDIEDALALGEELDSEYEEAFREGEASERQECQTLQAARFVDAWLEDAPEPGYYPTLGVRRDQGTDEIYGRAELYACLPGSVTGDLSADAHATVLMSATLRPFDVLEDVLGLDDPATMAYGLNFPEERRRTFAVDTPPLFSSDRDDPEVQATVAGALRDTVEFTPGNTLAFFPSYSEAERYHELLTGERNLVGGATGDGSGSAADTITLDDGTTAYLDRAGTSAEDLRQRFVEDDHAVLFTSLWGTLTEGVSFDGDDATSVAVVGVPYPHLDDRAKAVQEAYDLAFADRPVADPGWRYAVEIPTVRKTRQALGRVLRSPEDLGVRVLLDRRYTAAGQGQLGQYSVHDTFPPEEREELIDVAPGKLKFAIRNFYTDYAAYDGDPPIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9L8</accession>
    <name>R4W9L8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_14170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447667.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14170"/>
    <dbReference type="EnsemblBacteria" id="AGN02773">
        <property type="protein sequence ID" value="AGN02773"/>
        <property type="gene ID" value="L593_14170"/>
    </dbReference>
    <dbReference type="GeneID" id="16181113"/>
    <dbReference type="KEGG" id="sali:L593_14170"/>
    <dbReference type="eggNOG" id="arCOG04605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081182_0_0_2"/>
    <dbReference type="OrthoDB" id="75483at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="226" mass="24664" checksum="2AE20035340EF4ED" modified="2013-07-24" version="1">MPATTVHLGFGLLVAAALLPSERFDRNLLAVFAAILIFPDLDSIPGWWLPGAHRAMFHTLVLVGVAAAAIAYDTRVREVSWLRERGGDWAVRAAWALLATHLLAHLLLDWAHLSGINLLYPIGDQFFRLEGKLVYSTADGWIQTFVEIGSDDGGRTTIDVGQQGSTDDVHVSTPTDPEPGGGVDENVERIVPFAVHGWQLYLILLGLFTVGARRLQGEPPVSDREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9V5</accession>
    <name>R4W9V5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor 2</fullName>
            <shortName evidence="7">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ORF">L593_09595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446758.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_09595"/>
    <dbReference type="EnsemblBacteria" id="AGN01864">
        <property type="protein sequence ID" value="AGN01864"/>
        <property type="gene ID" value="L593_09595"/>
    </dbReference>
    <dbReference type="GeneID" id="16182765"/>
    <dbReference type="KEGG" id="sali:L593_09595"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1975"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OrthoDB" id="1642at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="7">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN01864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="730" mass="80712" checksum="E316E8888A6C8CCD" modified="2013-07-24" version="1">MGRRKKIVQQCERLMDNPEQIRNIAIAAHVDHGKTTLTDNLLAGAGMISDETAGEQLAMDTEEDEQERGITIDAANVSMTHEYEDEDYLINLIDTPGHVDFGGDVTRAMRAVDGALVVVDAVEGAMPQTETVLRQALREGVKPTLFINKVDRLISELQEGPEEMQERLLAVIRDVNELIRGMTEEMDDIDEDWTVGVEDGTVGFGSALYKWGVSMPSMQRTGMDFGDIIDLERADKRQELHEKTPLADVVLDMVCEHFPNPIDAQPHRIPRVWRGDPESELAGTMRDVDPEGEVVFMVTDIGVDPHAGEIATGRVFSGTLEEGQELYVSGTAGKNRVQSVGLFMGDEREEVDRVPAGNIASVTGLPDAIAGSTVSSVEMTPFESVDHISEPVITKAVEAKSMDDLPKLIETLRQVSKEDPTIQIEINEDTGEHLISGQGELHLEVQTQRIERNQGIPVKTGEPIVVFREAPQQPTDGEVEGISPNRHNRFYISVEPLDQELIDALKKGEVSMDMPEQERREALQDAGMDKDTSQNVEEIHGANIFVDDTKGIQHLNETMELVIEGLEEALDEGPLAGEPVEGALLRLHDARLHEDTIHRGPAQVIPAVRNAVHRALIHTEIRLLEPIQEVRIDVPNDHMGAASGEIQGRRGRVDDMYQEGDLMVVEGVAPVDEMIGFSSDIRSATEGRASWNTENAGFRVLADNLQRDIIGEIRERKGMKEELPEGVDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W9Y3</accession>
    <name>R4W9Y3_9EURY</name>
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        <submittedName>
            <fullName evidence="5">Oxidoreductase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L593_10295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Harcht-Bsk1</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AGN02004">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="236"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="4">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGN02004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="496" mass="53572" checksum="591D882CEFA047F0" modified="2013-07-24" version="1">MRETLQPKRTALFATVAGLAGLAVGYASGGWTRDYYAVVISDWVTEQTPAAMMNWAIQELGSTAETLQVLSAIGLAFAVLAAIAAVGLVVGYWHADAFLTGAALSTLLAGALAFVLTGDLLQTVLVAVGVGLPVAVGEYGGTALGKPRPVDPERREVVGVLGALLGIGVISKVLGDFLTSEAFQIDAEPLADAESLRERVETAQTTSLGIEGVQPPISEIGDFYNVSKNAAPEIVQESNWRLRVTGEVDEEIELNYRELREHESEDRFIALRCIGDSLNGDLLDTALWTGIPLAALFEEAGLQASHVEMHAADGYVASVPRETLENGFLAYGMNGDLLPREHGFPARIHLPGTWGELNVKWIEELHATNDPVEGFYEERGWNGHARVPAVAKIWTQPTNELEDGRQEVGGHAYAGDRGVETVEVSVDGGETWNEAELAEPLPGEDVTRQWRYRYRKEEEHEVVARVIDGEGDLQPQERSDAFPAGPSGWVSKTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA19</accession>
    <name>R4WA19_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpl19e</name>
        <name evidence="9" type="ORF">L593_11195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447078.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_11195"/>
    <dbReference type="EnsemblBacteria" id="AGN02184">
        <property type="protein sequence ID" value="AGN02184"/>
        <property type="gene ID" value="L593_11195"/>
    </dbReference>
    <dbReference type="GeneID" id="16181396"/>
    <dbReference type="KEGG" id="sali:L593_11195"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2309"/>
    <dbReference type="eggNOG" id="arCOG04089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OrthoDB" id="109335at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015973">
        <property type="entry name" value="Ribosomal_L19e_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015974">
        <property type="entry name" value="Ribosomal_L19e_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="8">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN02184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="155" mass="17749" checksum="A6711EEA033D74BF" modified="2013-07-24" version="1">MTDLSAQKRLAADVLDVGENRVWLDPEEQDELVDAITREDIRELVDEGVVRAKPKSGNSRGKARERSEKRAYGHQTGAGSRKGKAGGRQSEKDRWKRTARAQRQTLRELRDDGVLTPAQYRALYNKSRGGEFPDVRRLLNFAEDEYQIDVDRSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAF2</accession>
    <name>R4WAF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14550"/>
    <dbReference type="EnsemblBacteria" id="AGN02849">
        <property type="protein sequence ID" value="AGN02849"/>
        <property type="gene ID" value="L593_14550"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_14550"/>
    <dbReference type="eggNOG" id="arCOG04785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951937_0_0_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="31681" checksum="E0BFBDA9504262FD" modified="2013-07-24" version="1">MTEMMGSLASVYERFGDTQREFECCDTAFRIQATGVRAEAGATAARKTAESLESQLNAFDAASAVSQLNRDGEVRNEHVARIVRRGIEYNDRTGGVFDIHQGRVEHTLKTFLRGDSETLPTEFETGTVQTSGSHITTDVELDLNGLAKGYIVDRTAETLTGLGRCGFVSGGGDMSPPTGPVAIESPYGDDTPLKILDTDWYVATSGGYRRSRNGTNHVYDPTTESLGSRHESVTVLARRDCMEADALATTLAALPLVKARELASEWEGLEALIIHDGVFHTTDGFETHVLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R4WAG4</accession>
    <name>R4WAG4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo11</name>
        <name evidence="4" type="synonym">rpoL</name>
        <name evidence="6" type="ORF">L593_14875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447803.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14875"/>
    <dbReference type="EnsemblBacteria" id="AGN02909">
        <property type="protein sequence ID" value="AGN02909"/>
        <property type="gene ID" value="L593_14875"/>
    </dbReference>
    <dbReference type="GeneID" id="16181544"/>
    <dbReference type="KEGG" id="sali:L593_14875"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3038"/>
    <dbReference type="eggNOG" id="arCOG04111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_5_0_2"/>
    <dbReference type="OrthoDB" id="129321at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="92" mass="9764" checksum="E8A1A25FD0B13D21" modified="2013-07-24" version="1">MDLRVIDLSDEELSIEIAGEDHTFMNVLKGTLLETDGVEAATYDMNPEQSGGQTDPILTVKTDGVDPLEALEDAAGQVKEKTTALSDAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R4VVE2</accession>
    <name>R4VVE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445095.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01240"/>
    <dbReference type="EnsemblBacteria" id="AGN00201">
        <property type="protein sequence ID" value="AGN00201"/>
        <property type="gene ID" value="L593_01240"/>
    </dbReference>
    <dbReference type="GeneID" id="16182657"/>
    <dbReference type="KEGG" id="sali:L593_01240"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.252"/>
    <dbReference type="eggNOG" id="arCOG03295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143268_0_0_2"/>
    <dbReference type="OrthoDB" id="118601at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="141" mass="15421" checksum="643FAF70975BE36C" modified="2013-07-24" version="1">MGRPRPWLAALLAFLYPGLGHLYLREWARSLLWFVLGVGTVALALPENAVSEASVTDPNSIVTASETMTAEASTVGLLVVVTVFAFSIADAYTIARGARARRVREAAGETTPDCPVCGHELDEDLDFCHWCTTRLDEWEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R4W2I2</accession>
    <name>R4W2I2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5,10-methylenetetrahydromethanopterin reductase</fullName>
            <ecNumber evidence="4">1.5.98.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylene-H(4)MPT reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mer</name>
        <name evidence="6" type="ORF">L593_00135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:21144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57818"/>
            <dbReference type="ChEBI" id="CHEBI:58116"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
            <dbReference type="EC" id="1.5.98.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mer family.</text>
    </comment>
    <dbReference type="EC" id="1.5.98.2" evidence="4"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGM99981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_00135"/>
    <dbReference type="EnsemblBacteria" id="AGM99981">
        <property type="protein sequence ID" value="AGM99981"/>
        <property type="gene ID" value="L593_00135"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_00135"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.27"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018537">
        <property type="term" value="F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01091">
        <property type="entry name" value="F420_mer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019946">
        <property type="entry name" value="MeH4methanopterin_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGM99981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="37184" checksum="1A0DB93591EF64A0" modified="2013-07-24" version="1">MDVLRRERRRIGHGGIPVTRQRVGHAGIELTPEHPIDEVADLASHAETAGYDAVFVANHYFNRDPFAALIRIASVTDEIGVGTAGANPYDTHPVTLASRLATLQEASDGRAIFGVGPGDASALNSLGIDRERPLRRVLETLQVARQLWDGERVSHDGTFSTSDAGLEYDVERPPAYVAAQGPHMLRMGAKYGDGLLVNAAHPRDLSWATDRVAEGRAERDDGVDPEVLAYASVSIDENHDEARSLARRPVAFIAAGASPHVLDRHGLDSDRAEQIGQALERGAFHEAFDAVTPAMIDALSVAGSPEDVTERLAAIDDVVDGIVVGSPLGPDLRTAIDLAAEAIEQATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3L4</accession>
    <name>R4W3L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_03255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445496.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03255"/>
    <dbReference type="EnsemblBacteria" id="AGN00602">
        <property type="protein sequence ID" value="AGN00602"/>
        <property type="gene ID" value="L593_03255"/>
    </dbReference>
    <dbReference type="GeneID" id="16180234"/>
    <dbReference type="KEGG" id="sali:L593_03255"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.659"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN00602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="354" mass="39361" checksum="2E7B9D11A6C5FBEB" modified="2013-07-24" version="1">MRETLAEWRSVVDEAIEDVLPREIDEAYLEEYFGEPTYSYDAQAIQTALADPIWDLLDRGGKRWRAVLFLVLVDAFGEDPEEYLPYATIPEILHNGTIIVDDVEDGASKRRGEPALHHEFGQDVALNAGNAMYFIPLKIITHDPGDLGADTRLRAYEMLMHELNRTHLGQGMDICWHNEREVRMDEAEYLEMCACKTGCLGRIVARLAAIVTGQDEQVEEAVARYAEQVSIAFQIGDDILDVEHSLGEAGEFGKEFGNDVREGKKTLMAIHAIEHAPAEEAERLAAILAADENSGDEILEAIEILQSADSVAFARETALDLASDARGQLDDLDLAEGPEADLRAFTKFVVDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W3W2</accession>
    <name>R4W3W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L593_04030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445651.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04030"/>
    <dbReference type="EnsemblBacteria" id="AGN00757">
        <property type="protein sequence ID" value="AGN00757"/>
        <property type="gene ID" value="L593_04030"/>
    </dbReference>
    <dbReference type="GeneID" id="16182553"/>
    <dbReference type="KEGG" id="sali:L593_04030"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.819"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OrthoDB" id="45576at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="322"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AGN00757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="416" mass="44164" checksum="31DB39E553D1E7B0" modified="2013-07-24" version="1">MDVLESLRMAWQSIGSHRLRSALTLLGVVIGVGAVITFVVLGASLEEAVVGELTTGRSPAMTVFTQPEGADGFGGFDGGQVVFTERDLEEIRALQGVETVVPQGTVSLSGVTYANQTVGLPALTATTPAYFEETGEENFSAGGPFEPGEAQVVLNQQAATVFRTNVSVGDEIEIRRDGGETVTATVVGILEAPDDTAFGPSVSLPQVYGPTDPFVQTTLESPTTGERQRVYSRLTVVAVDYDRVDDVSDRVSTYLESDSDAAQLLPGSYETVVRTNEQFVRQIQTVLNRFTGFVTAIALISLVVGAVGIANIMLVSVTERTREIGIMKAVGFQNRDVLQLFLVEAVVLGLFGAILGLAVGMLAGYGVTQWLDLPFVLPVTWGAVAILVGIVVGVIAGLYPAWSAARIDPIEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R4W6B8</accession>
    <name>R4W6B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L593_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445177.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_01650"/>
    <dbReference type="EnsemblBacteria" id="AGN00283">
        <property type="protein sequence ID" value="AGN00283"/>
        <property type="gene ID" value="L593_01650"/>
    </dbReference>
    <dbReference type="GeneID" id="16179887"/>
    <dbReference type="KEGG" id="sali:L593_01650"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.335"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664998_0_0_2"/>
    <dbReference type="OrthoDB" id="20866at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AGN00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="409" mass="44642" checksum="8C50842353B5B95A" modified="2013-07-24" version="1">MDDHYDVVIAGAGPAGAQCARDVAARGYDVVVLETEAEDEFPAQSNKSTGGTFPSMMAAFGIPDDVVMQFTDEVVLESPNDFYVQDQPGAVLEFADFKRFLVADSQEKGADYIWDARVTAPLTEGGELVGVTYNGDEEVRGEVIVDATGPSAPLAKKLGVSNLERRNQAIGIEYEFEGVNLDADGHADLADAMMLRLDHDLAPGGYSWIFHTGDDTAKVGLCYIQNESYQRYATADRTIDGYLDYWVGKDPRLQDATRLEGKQHRGSAHIQPPTSLSTDSFMAIGDTVPTIDPLWGEGIHKCMKSARSAAIVADHALTGEVNTSAEKLSIYDKLWHQDVAPNVNKRLLMTKLLYLAPNGRYDQLMNDLRSAAKNTLAEANEGNKRAIASLLHLRDVPTLARLAKLHYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R4W798</accession>
    <name>R4W798_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="10" type="ORF">L593_04460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445737.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04460"/>
    <dbReference type="EnsemblBacteria" id="AGN00843">
        <property type="protein sequence ID" value="AGN00843"/>
        <property type="gene ID" value="L593_04460"/>
    </dbReference>
    <dbReference type="GeneID" id="16180946"/>
    <dbReference type="KEGG" id="sali:L593_04460"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.909"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="256" mass="27406" checksum="84A0BEACF036A4B1" modified="2013-07-24" version="1">MVDVDRAIDRMTEFLGDALVTTGADGYVVGVSGGLDSAVCATLAVEAVGNDAVTGMILPGAPSEDSNMADARELAADLGITCREVSIAPAVETFRQESPHEVGPRDAGNVRARTRMVFLYLEANVNGLLVLGPSNKSEILLGYFTKYGDGAADLRPMADLYKTEVRQVARALDLDETFVRKAPTAGLWEGQTDEGELGAAYETIDTVLKSLVEADESIEAAAERAGVGVEQAERFRRMMEDSEHKRTQPAAPELPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7A0</accession>
    <name>R4W7A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_04485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_04485"/>
    <dbReference type="EnsemblBacteria" id="AGN00848">
        <property type="protein sequence ID" value="AGN00848"/>
        <property type="gene ID" value="L593_04485"/>
    </dbReference>
    <dbReference type="KEGG" id="sali:L593_04485"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.914"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_2_2"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="448" mass="47497" checksum="C655196277578E4F" modified="2013-07-24" version="1">MSSLRSLLTRSRPGKLGLLEVVAMGVGGMVSGGIYAVLGVAMAQAGNAVPISYLVAGVITLLTAYSYLKLTLHFGEHGGVFSFVEHVVDSPTVAAYVGWVLVVGYVGVMAMYAFAFGAYTLTAARAVFGIALPQLLRPVLSVLVVAGFVGLNLTGVQETGLFEDVAVYVKIAILLSLAALGIAFYDGSVTAIDFFSEGVVSPITGFAIIFVSYEGFQLLVYDYEDIENVERVLPIGMYVAITIAILIYVSVSFMATLHLTPEQLVAHEEVALAEAVSQIPVLGSAGFVLVILSAMKSTSSGINATLFGTARLVHKIATEGALPRAFSFRNREGIPVYALLVMGALTAAFAALGSLKQITEFGSVAFLLSFAITNYTNLTLADVTGSNRLVPALGLLGTGVAIPIVLFHLYRTDVEILLWILGIFASIFLLEFLYVERRSFDPDAESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7G5</accession>
    <name>R4W7G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">7-keto-8-aminopelargonate synthetase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L593_14815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447791.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_14815"/>
    <dbReference type="EnsemblBacteria" id="AGN02897">
        <property type="protein sequence ID" value="AGN02897"/>
        <property type="gene ID" value="L593_14815"/>
    </dbReference>
    <dbReference type="GeneID" id="16181414"/>
    <dbReference type="KEGG" id="sali:L593_14815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.3026"/>
    <dbReference type="eggNOG" id="arCOG00113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_2_2"/>
    <dbReference type="OrthoDB" id="39668at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="51"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AGN02897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="412" mass="43455" checksum="831369D0AB3EEB07" modified="2013-07-24" version="1">MCERGFDLDDRLRERRSRTLYRDLQPADAVGHSARFAPDPGADLPVIEPDHQLVFAANNYLGLAGDERVVEAAQNAADVVGTGAGASRLVTGDTLVHRDLESRIADAKGTERALAFSSGYAANVGTIAALDPDVVFSDELNHASIVDGCRLADADVVVYDHCDPSDLRERMSERRAEPVAAGDVAVPNGGADESWLVVTDSVFSMDGTIAPFEALADLAEEFGAWLLADEAHATGCFVDGGGIVQRAGLEDRVQIQLGTLSKALGSQGGYVAGSSDLIEFLVNEARSFVYSTGLAPPAAAAAGEALHLARTTDRRARLWRNVDKLRDGLEDVGLDVGGETQILPVHVGDREDALALAAALRDRDVIAPAIRPPTVPEGTSRIRVAPMATHSAAELETCIDAFAVAADEVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R4W7W5</accession>
    <name>R4W7W5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="10" type="ORF">L593_06555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Harcht-Bsk1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446152.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_06555"/>
    <dbReference type="EnsemblBacteria" id="AGN01258">
        <property type="protein sequence ID" value="AGN01258"/>
        <property type="gene ID" value="L593_06555"/>
    </dbReference>
    <dbReference type="GeneID" id="16181801"/>
    <dbReference type="KEGG" id="sali:L593_06555"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1337"/>
    <dbReference type="eggNOG" id="arCOG00019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_0_1_2"/>
    <dbReference type="OrthoDB" id="70640at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGN01258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="292" mass="29596" checksum="8E5254E627665DCC" modified="2013-07-24" version="1">MSDDRLVADGGTDASPFDGEVTLPSALDAIAEQPPLVHCITNDVTVNDVANVTLHWGALPVMAVDPREVETMAGAAAGLYLNMGTVDEDEEEMIAAGQAANEAGTPVAFDPVGVGATPTRDEVAAEILEQVDVSIVKGNYGEVTALAGEDAEVQGVESVGEYAEIAETAMSLAADTDAVVVASGEVDVVADADAAYEVESGDPMMGRFVGTGCMLGVTEAVFAGALGEDRALEAALAGTAAFGVAGEDAAEEGDWNGPASYRTAFHDAVAAMTADGLDAGELDARVDLAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R4W862</accession>
    <name>R4W862_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_07865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN01518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020446412.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_07865"/>
    <dbReference type="EnsemblBacteria" id="AGN01518">
        <property type="protein sequence ID" value="AGN01518"/>
        <property type="gene ID" value="L593_07865"/>
    </dbReference>
    <dbReference type="GeneID" id="16182273"/>
    <dbReference type="KEGG" id="sali:L593_07865"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.1611"/>
    <dbReference type="eggNOG" id="arCOG03053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014178_0_0_2"/>
    <dbReference type="OrthoDB" id="118938at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN01518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="274" mass="27001" checksum="59ABF60521872612" modified="2013-07-24" version="1">MKRTVAVSLLVVGLLLAPLAAAAAPGLAGGDAADGGQETNESFTAGERLSGAIGAERAELDGEVSERSFGAALAATETNDSAAGVVGERLDHIQQRLDDLESRNETLAAQYENGTISRGAYAARAAAIEAERASLTRQLGAVENATGRLPADALVANGVNASAIERLRGQASELGGQQVRELARSIAGPNLGNGIGPGDRAPDEIPGLGGDGLPGERGPEDRPGNGGGNDADGNETDGSGDGDATGGDDGTGSDADGGDGGTDTDAGSEDDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8G2</accession>
    <name>R4W8G2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_03390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN00629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020445523.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_03390"/>
    <dbReference type="EnsemblBacteria" id="AGN00629">
        <property type="protein sequence ID" value="AGN00629"/>
        <property type="gene ID" value="L593_03390"/>
    </dbReference>
    <dbReference type="GeneID" id="16181757"/>
    <dbReference type="KEGG" id="sali:L593_03390"/>
    <dbReference type="eggNOG" id="arCOG01994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044678_0_0_2"/>
    <dbReference type="OrthoDB" id="48799at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN00629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="502" mass="52742" checksum="792CC79038F0D474" modified="2013-07-24" version="1">MSLDDAVRDSVRAFGARPAKVLPFYVAGLAVPVITRVVPVVGLFLAYLSLRGSGRIEAVRDELEGESPIGFEDPGTTDVDEEALGEALLDLLTPTVIAILLVTTLLAIVLFAVMQAAVSAGRLHAVYAVLSDGDATEAGVDGVFADTWTFLGLAIVELLAYLFLFGIPTALVAVAVGLDLVLLALPAIPLFLLAAVASLGVRLLFAFARPAIVVDDAGVVAGIRGALGYVRRNLTVAIGYGTLTIGLLVAANVVSGAFSQLGAVTVTTLLPLVFVFPLVDLVKTRLYADDAEVDLSPPTSPEADRLPRLRAGFARGWSALWTFTRGHLGLVGVSTVVLLAGVWVGLWAGAQVDDLFAASIEARLDRQGPVGAFFNYAANNWSVAAGQSLSGLVFGLPTIVSLAFNGANVGFLYQLEVEPEILVAFVLPHGIVEVPALLLSGALGLHLGRLGWGYVFGSVSRERLADDIDRGFQVLVGLAILFVLAAVIEAFVSPYYWRLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R4W8V0</accession>
    <name>R4W8V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L593_10815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447002.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_10815"/>
    <dbReference type="EnsemblBacteria" id="AGN02108">
        <property type="protein sequence ID" value="AGN02108"/>
        <property type="gene ID" value="L593_10815"/>
    </dbReference>
    <dbReference type="GeneID" id="16180560"/>
    <dbReference type="KEGG" id="sali:L593_10815"/>
    <dbReference type="PATRIC" id="fig|1333523.5.peg.2232"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OrthoDB" id="115808at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGN02108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="393" mass="41995" checksum="7DE9C896C5DAFC21" modified="2013-07-24" version="1">MYDFVVVGLGPAGSRFARRAAEEGYDVIGFEQGQVGEPLACSGHVSTDVWEITGDGAREELLQNEVYGARFHVDGPAADGGAEPNGGKGAANAAGDERTPDDSARTEGHDLDGAYPFYKDEPVSNVIDRVGLDRHLADLAREAGADCREEHTVTAVEEHADHVTATVRGPDGTETFDAKMVAGCDGPRSRVRDALDLPEPDEFLHGVLGFTDDPDHADFVDVHLTPPRFFAWRIPRGDAGVEFGLATPPDQHAGEAFESFCEAYGVEVSRRCSGAIPIGPPSEVTGDRGFLIGDAAGQTKPFTGGGIRYGTTCADHAIATIDPDDPGTLADYETAWRDDLAREIRLGHAIRRAYSLPTTVQRAGLRAFSGEIGVHMDRPTSLFSAKQLRALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R4WA80</accession>
    <name>R4WA80_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L593_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Salinarchaeum sp. Harcht-Bsk1</name>
        <dbReference type="NCBI Taxonomy" id="1333523"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Salinarchaeum</taxon>
            <taxon>unclassified Salinarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="Genome Announc." volume="1" first="E00505" last="13">
            <title>Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T, Isolated from Hypersaline Lake Baskunchak, Russia.</title>
            <authorList>
                <person name="Dominova I.N."/>
                <person name="Sorokin D.Y."/>
                <person name="Kublanov I.V."/>
                <person name="Patrushev M.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
            <dbReference type="PubMed" id="23868130"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Harcht-Bsk1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP005962">
        <property type="protein sequence ID" value="AGN02489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020447383.1">
        <property type="nucleotide sequence ID" value="NC_021313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1333523.L593_12750"/>
    <dbReference type="EnsemblBacteria" id="AGN02489">
        <property type="protein sequence ID" value="AGN02489"/>
        <property type="gene ID" value="L593_12750"/>
    </dbReference>
    <dbReference type="GeneID" id="16180154"/>
    <dbReference type="KEGG" id="sali:L593_12750"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061377_0_0_2"/>
    <dbReference type="OrthoDB" id="47121at2157"/>
    <dbReference type="Proteomes" id="UP000014072">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="204"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AGN02489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000014072"/>
        </source>
    </evidence>
    <sequence length="348" mass="36955" checksum="BBE57779CB74D2FC" modified="2013-07-24" version="1">MYAGVPLSEEMAYARLIDRLEAPASPTVTTLPDGSVDHFCSLADSVGPSTHTREAFSRAITGDRSSFRLDVESVESGGQSVNAALQLHALGSAVTAYGHFDAEIFTSLPFETVSMGTPADVYVLSFDDRDLMLVSDGDVGDWTLERLESVTDLDAAFDADAICCSNWAGVPGLEDAFHRLGDATFPRRPFVFDPGDVVGCAPGELESMCAALSALQETFDVVFNANREEIRATASILPGSLEDDGERLLAIREELGITAAVMHAKKEAATATADGLCTLPNLQVDRPTRQAGGGDRFSGGLGYALARGWDWETATACGNACASYYVESGTTGDPEELIAFLSDRSLRA</sequence>
</entry>
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Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>